Tag: drug

ChEMBL is a manually curated database of bioactive molecules with drug-like properties. It brings together chemical, bioactivity and genomic data to aid the translation of genomic information into effective new drugs.

The information in the database is presented at two levels: the initial view or landing pages for each target family provide expert-curated overviews of the key properties and selective ligands and tool compounds available. For selected targets more ...

Database that aims to advance understanding about how environmental exposures affect human health. It provides manually curated information about chemical–gene/protein interactions, chemical–disease and gene–disease relationships. These data are inte ...

ClinicalTrials.gov, a largest source of clinical trials data in the US, is a Web-based resource that provides patients, their family members, health care professionals, researchers, and the public with easy access to information on publicly and priva ...

The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug data with comprehensive drug target information.

PharmGKB is a resource that provides information about how human genetic variation affects response to medications. PharmGKB collects, curates and disseminates knowledge about clinically actionable gene-drug associations and genotype-phenotype relati ...

The Virus Pathogen Database and Analysis Resource (ViPR) is an integrated repository of data and analysis tools for multiple virus families, supported by the National Institute of Allergy and Infectious Diseases (NIAID) Bioinformatics Resource Center ...

A bioinformatic database of antimicrobial resistance genes, their products and associated phenotypes.

The GPCRDB is a molecular-class information system that collects, combines, validates and stores large amounts of heterogenous data on G protein-coupled receptors (GPCRs). The GPCRDB contains data on sequences, ligand binding constants and mutations. ...

The Antimicrobial Peptide Database (APD) contains information on antimicrobial peptides from across a wide taxonomic range. It includes a glossary, nomenclature, classification, information search, prediction, design, and statistics of AMPs. The anti ...

TDR Targets integrates chemical and genomic information and allows users to prioritize targets and compounds to develop and repurpose new drugs and chemical tools for human pathogens. The TDR Target Project was started in 2005 after a call for applic ...

RxNorm provides normalized names for clinical drugs and links its names to many of the drug vocabularies commonly used in pharmacy management and drug interaction software, including those of First Databank, Micromedex, MediSpan, Gold Standard Drug D ...

The Therapeutic Target Database provides information about therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets. Also included in this database are links ...

Drug-related information: medical indications, adverse drug effects, drug metabolism and Gene Ontology terms of the target proteins.

BindingDB enables research by making a growing collection of high-quality, quantitative, protein-ligand binding data findable and usable. Funded by NIGMS/NIH.

SIDER contains information on marketed medicines and their recorded adverse drug reactions. The information is extracted from public documents and package inserts. The available information include side effect frequency, drug and side effect classifi ...

Orphanet is a unique resource, gathering and improving knowledge on rare diseases so as to improve the diagnosis, care and treatment of patients with rare diseases. Orphanet aims to provide high-quality information on rare diseases, including ...

The Chemical Effects in Biological Systems (CEBS) database houses data of interest to environmental health scientists. CEBS is a public resource, and has received depositions of data from academic, industrial, and governmental laboratories.

The GeneWeaver data and analytics website is a publically available resource for storing, curating and analyzing sets of genes from heterogeneous data sources. The system enables discovery of relationships among genes, variants, traits, drugs, enviro ...

CAMPR3 (Collection of Anti-Microbial Peptides) has been generated to enhance research into AMP families. The collection is compatible with well-known databases such as PubMed and Uniprot with information like sequence, protein definition, accession n ...

The Chemical Probes Portal is an online open access catalog of annotated small molecule inhibitors, agonists and other chemical tools for biological research and preclinical drug discovery. Annotations for are extensive and distinguish between activi ...

Open TG-GATEs is a public toxicogenomics database developed so that a wider community of researchers could utilize the fruits of TGP and TGP2 research. This database provides public access to data on 170 of the compounds catalogued in TG-GATEs. Data ...

ChemDB is a chemical database containing nearly 5M commercially available small molecules, important for use as synthetic building blocks, probes in systems biology and as leads for the discovery of drugs and other useful compounds.

Toxin and Toxin Target Database (T3DB) is a bioinformatics resource that combines detailed toxin data with comprehensive toxin target information.

The Pancreatic Expression Database (PED) is a repository for pancreatic-derived -omics data. With a generic web-based system, the database provides the research community with an open access tool to mine currently available pancreatic cancer experime ...

BACTIBASE contains calculated or predicted physicochemical properties of bacteriocins produced by both Gram-positive and Gram-negative bacteria. The information in this database is very easy to extract and allows rapid prediction of relationships str ...

The Ontology of Coronavirus Infectious Disease (CIDO) is a community-driven open-source biomedical ontology in the area of coronavirus infectious disease. The CIDO is developed to provide standardized human- and computer-interpretable annotation and ...

DrugCentral is online drug information that provides information on active ingredients, chemical entities, pharmaceutical products, drug mode of action, indications, and pharmacologic mode of action. DrugCentral monitors FDA, EMA, and PMDA for new dr ...

PathBank is an interactive, visual database containing more than 100 000 machine-readable pathways found in model organisms such as humans, mice, E. coli, yeast, and Arabidopsis thaliana. The majority of these pathways are not found in any other path ...

The goal of the Pathway Ontology is to cover all types of biological pathways, including altered and disease pathways, and to capture the relationships between them within the hierarchical structure of a Directed Acyclic Graph (DAG). The five nodes o ...

LAB provides a standard model for the acquisition and exchange of laboratory data, primarily between labs and sponsors or CROs. The LAB standard was specifically designed for the interchange of lab data acquired in clinical trials.

SureChEMBL is a publicly available large-scale resource containing compounds extracted from the full text, images and attachments of patent documents. The data are extracted from the patent literature according to an automated text and image-mining p ...

An ontology of drug products and packaged drug products.

PDX Finder is an open repository for the upload and storage of clinical, genomic and functional Patient-Derived Xenograph (PDX) data which provides a comprehensive global catalogue of PDX models available for researchers across distributed repository ...

Herbal active Ingredients and their Targets

The Anatomical Therapeutic Chemical (ATC) Classification System is used for the classification of active ingredients of drugs according to the organ or system on which they act and their therapeutic, pharmacological and chemical properties. It is con ...

The NIDA Data Share web site is an electronic environment that allows data from completed clinical trials to be distributed to investigators and the public in order to promote new research, encourage further analyses, and disseminate information to t ...

SO-Pharm is a formal ontology that represent domain knowledge in pharmacogenomics. To achieve this goal, SO-Pharm articulates ontologies from sub domains of phamacogenomics (i.e. genotype, phenotype, drug, trial representations). SO-Pharm enables to ...

The Jackson Laboratory Clinical Knowledgebase (CKB) is a semi-automated/manually curated database of gene/variant annotations, therapy knowledge, diagnostic/prognostic information, and clinical trials related to oncology. CKB not only contains curren ...

The Enzyme Portal is for those interested in the biology of enzymes and proteins with enzymatic activity. It integrates publicly available information about enzymes, such as small-molecule chemistry, biochemical pathways and drug compounds. It contai ...

IPPI-DB is a database of modulators of protein-protein interactions. It contains exclusively small molecules and therefore no peptides. The data are retrieved from the literature either peer reviewed scientific articles or world patents. A large vari ...

Chem2Bio2RDF has been created by aggregating data from multiple chemogenomics repositories and is cross-linked into Bio2RDF and LODD. There is also a linked-path generation tool to facilitate SPARQL query generation, and have created extended SPARQL ...

Protein-protein and drug-protein interactions for studies of drug repositioning

Antiviral peptides (AVPs) have exhibited huge potential in inhibiting viruses by targeting various stages of their life cycle. Therefore, we have developed AVPdb, available online at http://crdd.osdd.net/servers/avpdb, to provide a dedicated resource ...

WITHDRAWN is a database of withdrawn and discontinued drugs that were recalled from global markets due to safety concerns. The database serves as a useful resource with information about the therapeutic (or primary) targets, off-targets, toxicity typ ...

The CommonEvidenceModel (CEM) provides an evidence base of a wide variety of sources with information relevant for assessing associations between drugs and health outcomes of interest.

NAHDAP acquires, preserves and disseminates data relevant to drug addiction and HIV research. The scope of the data housed at NAHDAP covers a wide range of legal and illicit drugs (alcohol, tobacco, marijuana, cocaine, synthetic drugs, and others) an ...

The Ontology of Adverse Events (OAE) is a community-driven ontology that is developed to standardize and integrate data on biomedical adverse events (e.g., vaccine and drug adverse events) and support computer-assisted reasoning. As a result of a med ...

Antihypertensive peptides database

Physician Data Query (PDQ) Terminology is part of NCI's comprehensive cancer information database, which contains expert summaries on a wide range of cancer topics, a listing of some 30,000 cancer clinical trials from around the world, a directory of ...

Biomarkers of exposure to disease risk factors

The Database of Antimicrobial Activity and Structure of Peptides (DBAASP) is an open-access, comprehensive database containing information on amino acid sequences, chemical modifications, 3D structures, bioactivities and toxicities of peptides that p ...

Veterans Health Administration National Drug File is a centrally maintained electronic drug list used by the VHA hospitals and clinics. Facilities use the NDF to check drug interactions, to manage orders, and to send outpatient prescriptions to regio ...

Drug2Gene is a free multi-species drug-target knowledge base. It contains integrated and unified data of publicly available relations between drugs/compounds and their gene/protein targets gathered from 20 publicly available bio- and chemoinformatics ...

A resource for computational drug design and discovery

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Data and Specimen Hub (DASH) is a centralized resource that allows researchers to share and access de-identified data from studies funded by NICHD. DASH also ...

The Adverse Drug Reaction Markup Language (EU-ADR ML) was created to as part of the EU-ADR project. The ultimate aim of this project was to develop an innovative approach to the early detection of adverse drug reactions. The status of this format is ...

Experimentally validated Cell Penetrating Peptides

Read Codes are a coded thesaurus of clinical terms. They have been used in the NHS since 1985. There are two versions: version 2 (v2) and version 3 (CTV3 or v3). Both versions provide a standard vocabulary for clinicians to record patient findings an ...

The Functional Therapeutic Chemical Classification System (FTC) defines over 20,000 mechanisms and modes of action for approved drugs. The resource abstracts away from the traditional chemical structure-based approach and focuses solely on the mode o ...

The National Drug Data File vocabulary supports clinical research and patient care. Please note that we have been unable to confirm the current status of NDDF and its relationship with FDB MedKnowledge. Until that time, the FAIRsharing team has marke ...

Master Drug Data Base provides comprehensive and current drug information from a single source. The resource provides pricing and descriptive drug information on name brand, generic, prescription and OTC medications, and herbal products. It includes ...

This project focuses on the development of a high level patient-centric ontology for the pharmaceutical industry. The ontology should enable silos in discovery research, hypothesis management, experimental studies, compounds, formulation, drug develo ...

G-quadruplex Ligands Database

Minimal information for Chemosensitivity Assays (MICHA) is both a web tool to aid annotation of drug sensitivity screens and a guideline for defining the minimal information required to: capture critical drug sensitivity assay components, allow the F ...

DDIEM - Drug Database for inborn errors of metabolism is a database on therapeutic strategies for inborn errors of metabolism. These strategies are classified by mechanism and outcome in DDIEM ontology. DDIEM uses this ontology to categorize the expe ...

DDIEM Ontology for the Drug Database for Inborn Errors of Metabolism. The DDIEM database is a database of therapeutic strategies and treatments for inborn errors of metabolism. These strategies are classified by mechanism and outcome using the DDIEM ...

The Health Canada Drug Product Database contains product specific information on drugs approved for use in Canada. The database is managed by Health Canada and includes human pharmaceutical and biological drugs, veterinary drugs and disinfectant prod ...

A database of molecular replacements for ligand design

The Parasite Experiment Ontology (PEO) models the processes, instruments, parameters, and sample details that will be used to annotate experimental results with “provenance” metadata (derivation history of results). The ontology was created to enable ...

A database of structurally annotated peptides

The pharmacovigilance ontology connects known facts on drugs, disease, ADEs, and their molecular mechanisms.

Orphadata provides the scientific community with comprehensive, quality datasets related to rare diseases and orphan drugs from the Orphanet knowledge base, in reusable formats.

Nutritional and medicinal value of plant-based foods

Human disease-related phenotypes in model organisms

The database contains approximately 2500 3D-structures of active ingredients of essential marketed drugs. For selection purposes and for correlation of structural similarity with medical application, the assignment of the Anatomical Therapeutic Chemi ...

The HIV Drug Resistance Database is a compilation of mutations in HIV genes that confer resistance to anti-HIV drugs. Currently, 673 mutations to RT, Protease, Env, Gag, Integrase, FIV RT and SIV RT are stored. The database may be searched by gene, c ...

A database for facilitating the search for drug adverse reaction target. It contains information about known drug adverse rection targets, functions and properties. Associated references are also included.

Adverse Drug Reaction Classification System

Heterogenous data on unstudied and understudied drug targets

Genomics of Drug Sensitivity in Cancer: Sensitivity for anti-cancer drugs in various cell lines

Potential drug-binding sites in protein structures from the PDB

G-protein coupled receptors (GPCRs) represent one of the most important families of drug targets in pharmaceutical development. GLIDA is a novel public GPCR-related chemical genomic database that is primarily focused on the correlation of information ...

The Variability of Drug Transporter Database (VARIDT) is constructed to provide the comprehensive data of all aspects of drug transporter variability. Based on the comprehensive review on all FDA approved and >2,000 clinical trial drugs, VARIDT confi ...

Vaccine Investigation and Online Information Network

Natural compounds and their suppliers

Mechanisms of antimicrobial resistance

Essential Host Factors for Pathogenic Infection

The Interactome of Drug-Metabolizing Enzymes (INTEDE) is a database designed to systematically provide the data of all types of drug-metabolizing enzyme (DME) interaction. INTEDE confirmed 1,047 unique DMEs (448 host and 599 microbial), for the first ...

Biologically relevant ligand-protein interactions

Naturally occuring Plant based Anticancerous Compound Targets

Biotransformation of xenobioitics - drugs and food ingredients - by human enzymes

The database aims to bridge the gap between agent repositories and studies documenting the effect of antimicrobial combination therapies. Most notably, our primary aim is to compile data on the combination of antimicrobial agents, namely natural prod ...

Drug repositioning, the process of discovering, validating, and marketing previously approved drugs for new indications, is of growing interest to academia and industry due to reduced time and costs associated with repositioned drugs. Computational m ...

Wiki-Pi is a wiki resource centered on human protein-protein interactions. Wiki-Pi's intuitive search functionality allows you to retrieve and discover interactions effectively.

The Peptaibol Database is a sequence and structure resource for the unusual class of peptides known as peptaibols. The database includes sequence, biological source, and bibliographical data for the naturally-occurring peptaibols. Information is also ...

The defensins knowledgebase is a manually curated database and information source devoted to the defensin family of antimicrobial peptides. The current version of the database holds a comprehensive collection of over 350 defensin records each contain ...

The Host Genetic and Immune Factors Shaping Human Microbiota (GIMICA) is a database systematically providing host genetic factors (HGFs) and host immune factors (HIFs). Both factors are essential for defining the chemical and physical landscapes inha ...

Antibiotic resistance has become a major human health concern due to widespread use, misuse and overuse of antibiotics. In addition to antibiotics, antibacterial biocides and metals can contribute to the development and maintenance of antibiotic resi ...