TTD, Therapeutic Target Database
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TTD, Therapeutic Target Database
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
TTD
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:56.958597
ttd
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:56.958597
Names
More detailed information about this field from each metasource.
TTD, Therapeutic Target Database
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
TTD
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:56.958597
ttd
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:56.958597
Names
More detailed information about this field from each metasource.
TTD, Therapeutic Target Database
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
TTD
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:56.958597
ttd
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:56.958597
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The Therapeutic Target Database provides information about therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets. Also included in this database are links to relevant databases containing information about target function, sequence, 3D structure, ligand binding properties, enzyme nomenclature and drug structure, therapeutic class, clinical development status. All information is fully referenced.
Description
More detailed information about this field from each metasource.
The Therapeutic Target Database provides information about therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets. Also included in this database are links to relevant databases containing information about target function, sequence, 3D structure, ligand binding properties, enzyme nomenclature and drug structure, therapeutic class, clinical development status. All information is fully referenced.
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
The Therapeutic Target Database (TTD) provides information about known and explored therapeutic targets, which is unique in validating the primary therapeutic target for each drug by collectively considering (1) the activity of a drug against its target, (2) the in vivo experiments verifying the role of targets in disease models, and (3) the experimental evidence that drug is effectively against drug target in disease model. Based on this strategy, TTD strictly determined primary therapeutic targets of all FDA-approved and >9,000 clinical trial drugs. To promote the drug discovery for COVID-19, TTD comprehensively provided the drug candidates in clinical test, and identified their therapeutic target. It covers 315 unique drug entities and 76 well-validated therapeutic targets for the treatment of COVID-19.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Therapeutic Target Database (TTD) has been developed to provide information about therapeutic targets and corresponding drugs. TTD includes information about successful, clinical trial and research targets, approved, clinical trial and experimental drugs linked to their primary targets, new ways to access data by drug mode of action, recursive search of related targets or drugs, similarity target and drug searching, customized and whole data download, and standardized target ID.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:56.958597
Webpage:
http://bidd.nus.edu.sg/group/ttd/ttd.aspWebpage
More detailed information about this field from each metasource.
http://bidd.nus.edu.sg/group/ttd/ttd.asp
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://db.idrblab.org/ttd/
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
http://bidd.nus.edu.sg/group/cjttd/
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:56.958597
Publications:
Publications
More detailed information about this field from each metasource.
TTD: Therapeutic Target Database
PMID: 11752352
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
Update of TTD: Therapeutic Target Database
PMID: 19933260
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:56.958597
Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information
PMID: 26578601
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
Therapeutic target database update 2014: a resource for targeted therapeutics
PMID: 24265219
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
https://doi.org/10.1093/nar/gkz981
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
More detailed information about this field from each metasource.
TTD: Therapeutic Target Database
PMID: 11752352
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
Update of TTD: Therapeutic Target Database
PMID: 19933260
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:56.958597
Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information
PMID: 26578601
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
Therapeutic target database update 2014: a resource for targeted therapeutics
PMID: 24265219
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
https://doi.org/10.1093/nar/gkz981
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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TTD: Therapeutic Target Database
PubMed citations: 202.
202 articles citing: TTD: Therapeutic Target Database
Combining empirical knowledge, in silico molecular docking and ADMET profiling to identify therapeutic phytochemicals from Brucea antidysentrica for acute myeloid leukemia. PMID:35895695
Comprehensive Assessment of Indian Variations in the Druggable Kinome Landscape Highlights Distinct Insights at the Sequence, Structure and Pharmacogenomic Stratum. PMID:35865963
Artificial intelligence and machine-learning approaches in structure and ligand-based discovery of drugs affecting central nervous system. PMID:35819579
A Mechanistic Exploratory Study on the Therapeutic Efficacy of Astragaloside IV Against Diabetic Retinopathy Revealed by Network Pharmacology. PMID:35814228
Network Pharmacology and Data Mining Approach Reveal the Medication Rule of Traditional Chinese Medicine in the Treatment of Premenstrual Syndrome/Premenstrual Dysphoric Disorder. PMID:35800440
Network Pharmacology Approach for Medicinal Plants: Review and Assessment. PMID:35631398
Licoflavone A Suppresses Gastric Cancer Growth and Metastasis by Blocking the VEGFR-2 Signaling Pathway. PMID:35509849
Mechanism of Jujube (Ziziphus jujuba Mill.) Fruit in the Appetite Regulation Based on Network Pharmacology and Molecular Docking Method. PMID:35480085
Identification of Key Genes and Pathways in Peripheral Blood Mononuclear Cells of Type 1 Diabetes Mellitus by Integrated Bioinformatics Analysis. PMID:35381625
Revealing Calcium Signaling Pathway as Novel Mechanism of Danhong Injection for Treating Acute Myocardial Infarction by Systems Pharmacology and Experiment Validation. PMID:35281886
An in silico and in vitro integrated analysis method to reveal the curative mechanisms and pharmacodynamic substances of Bufei granule on chronic obstructive pulmonary disease. PMID:35266101
Exploring the Potential Antidepressant Mechanisms of Pinellia by Using the Network Pharmacology and Molecular Docking. PMID:35230627
Transcriptome-Based Molecular Networks Uncovered Interplay Between Druggable Genes of CD8+ T Cells and Changes in Immune Cell Landscape in Patients With Pulmonary Tuberculosis. PMID:35198572
Network Pharmacology and Molecular Docking Analysis on Pharmacological Mechanisms of Astragalus membranaceus in the Treatment of Gastric Ulcer. PMID:35140802
The System Research of the Molecular Mechanism of Quyushengxin Capsule in the Treatment of Osteonecrosis of the Femoral Head. PMID:35069756
Proteomic Characterization and Target Identification Against Streptococcus mutans Under Bacitracin Stress Conditions Using LC-MS and Subtractive Proteomics. PMID:34989956
Potential Mechanism of Dingji Fumai Decoction Against Atrial Fibrillation Based on Network Pharmacology, Molecular Docking, and Experimental Verification Integration Strategy. PMID:34859062
Identification of the Active Constituents and Significant Pathways of Shen-qi-Yi-zhu Decoction on Antigastric Cancer: A Network Pharmacology Research and Experimental Validation. PMID:34853601
Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge. PMID:34834924
A Novel In Silico Benchmarked Pipeline Capable of Complete Protein Analysis: A Possible Tool for Potential Drug Discovery. PMID:34827106
Learning from low-rank multimodal representations for predicting disease-drug associations. PMID:34736437
Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities. PMID:34705221
Gene Network Analysis of Alzheimer's Disease Based on Network and Statistical Methods. PMID:34682089
The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design. PMID:34675489
Drug repositioning by merging active subnetworks validated in cancer and COVID-19. PMID:34615934
Myrtenal and β-caryophyllene oxide screened from Liquidambaris Fructus suppress NLRP3 inflammasome components in rheumatoid arthritis. PMID:34583676
Comprehensive Survey of Recent Drug Discovery Using Deep Learning. PMID:34576146
Losartan and Eprosartan Induce a Similar Effect on the Acute Rise in Serum Uric Acid Concentration after an Oral Fructose Load in Patients with Metabolic Syndrome. PMID:34527078
An Efficient Synthesis of 2-CF3-3-Benzylindoles. PMID:34443672
Network Pharmacology Approach for Predicting Targets of Zishen Yutai Pills on Premature Ovarian Insufficiency. PMID:34394393
Machine learning approaches for drug combination therapies. PMID:34368832
Exploring the Mechanism of Scutellaria baicalensis Georgi Efficacy against Oral Squamous Cell Carcinoma Based on Network Pharmacology and Molecular Docking Analysis. PMID:34335829
Host metabolic reprogramming in response to SARS-CoV-2 infection: A systems biology approach. PMID:34333072
Network-based repurposing identifies anti-alarmins as drug candidates to control severe lung inflammation in COVID-19. PMID:34293006
Computational Drug Repurposing for Alzheimer's Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies. PMID:34276354
Study of the Active Components and Molecular Mechanism of Tripterygium wilfordii in the Treatment of Diabetic Nephropathy. PMID:34164430
Evolving scenario of big data and Artificial Intelligence (AI) in drug discovery. PMID:34159484
Investigating the active compounds and mechanism of HuaShi XuanFei formula for prevention and treatment of COVID-19 based on network pharmacology and molecular docking analysis. PMID:34105049
Personalized Medicine for Neuroblastoma: Moving from Static Genotypes to Dynamic Simulations of Drug Response. PMID:34064704
Structure-based drug repurposing against COVID-19 and emerging infectious diseases: methods, resources and discoveries. PMID:33993214
Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example. PMID:33946982
A Highly Selective In Vitro JNK3 Inhibitor, FMU200, Restores Mitochondrial Membrane Potential and Reduces Oxidative Stress and Apoptosis in SH-SY5Y Cells. PMID:33918172
A New Insight for the Identification of Oncogenic Variants in Breast and Prostate Cancers in Diverse Human Populations, With a Focus on Latinos. PMID:33912047
PreDTIs: prediction of drug-target interactions based on multiple feature information using gradient boosting framework with data balancing and feature selection techniques. PMID:33709119
Systematic insight into the active constituents and mechanism of Guiqi Baizhu for the treatment of gastric cancer. PMID:33682294
Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions. PMID:33672092
Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation. PMID:33645621
Drug repurposing for COVID-19 via knowledge graph completion. PMID:33571675
Therapeutic Targeting of Nemo-like Kinase in Primary and Acquired Endocrine-resistant Breast Cancer. PMID:33542078
G-Protein-Coupled Receptor and Ion Channel Genes Used by Influenza Virus for Replication. PMID:33536179
Development, optimization and characterization of nanoemulsion loaded with clove oil-naftifine antifungal for the management of tinea. PMID:33517791
Potential effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification. PMID:33513419
Potential Herb-Drug Interactions in the Management of Age-Related Cognitive Dysfunction. PMID:33478035
An efficient computational method for predicting drug-target interactions using weighted extreme learning machine and speed up robot features. PMID:33472664
An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease. PMID:33466870
Screening druggable targets and predicting therapeutic drugs for COVID-19 via integrated bioinformatics analysis. PMID:33428154
Pathway Maps of Orphan and Complex Diseases Using an Integrative Computational Approach. PMID:33376724
Uncovering the pharmacological mechanism of the effects of the Banxia-Xiakucao Chinese Herb Pair on sleep disorder by a systems pharmacology approach. PMID:33235305
Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans. PMID:33216250
KG-COVID-19: A Framework to Produce Customized Knowledge Graphs for COVID-19 Response. PMID:33196056
A Machine Learning Method for Drug Combination Prediction. PMID:33193585
Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID-19. PMID:33140889
Anticancer drug synergy prediction in understudied tissues using transfer learning. PMID:33040150
Ensemble Learning Prediction of Drug-Target Interactions Using GIST Descriptor Extracted from PSSM-Based Evolutionary Information. PMID:32908888
Network Pharmacology-Based Approach to Revealing Biological Mechanisms of Qingkailing Injection against IschemicStroke: Focusing on Blood-Brain Barrier. PMID:32908557
A Bioinformatics Research on Novel Mechanism of Compound Kushen Injection for Treating Breast Cancer by Network Pharmacology and Molecular Docking Verification. PMID:32849897
KG-COVID-19: a framework to produce customized knowledge graphs for COVID-19 response. PMID:32839776
Predicting novel drugs for SARS-CoV-2 using machine learning from a >10 million chemical space. PMID:32802980
Mechanisms of Spica Prunellae against thyroid-associated Ophthalmopathy based on network pharmacology and molecular docking. PMID:32689994
Co-expression network analysis identifies a gene signature as a predictive biomarker for energy metabolism in osteosarcoma. PMID:32581649
pyMeSHSim: an integrative python package for biomedical named entity recognition, normalization, and comparison of MeSH terms. PMID:32552728
Reveal the Regulation Patterns of Prognosis-Related miRNAs and lncRNAs Across Solid Tumors in the Cancer Genome Atlas. PMID:32523951
ThETA: transcriptome-driven efficacy estimates for gene-based TArget discovery. PMID:32437556
Transcriptional and Cellular Diversity of the Human Heart. PMID:32403949
Towards the routine use of in silico screenings for drug discovery using metabolic modelling. PMID:32369553
A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer's Disease. PMID:32143538
Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors. PMID:32085474
Machine learning approaches and databases for prediction of drug-target interaction: a survey paper. PMID:31950972
Ifenprodil and Flavopiridol Identified by Genomewide RNA Interference Screening as Effective Drugs To Ameliorate Murine Acute Lung Injury after Influenza A H5N1 Virus Infection. PMID:31822599
An omics perspective on drug target discovery platforms. PMID:31774113
Computational/in silico methods in drug target and lead prediction. PMID:31711157
Systems Pharmacology-Based Method to Assess the Mechanism of Action of Weight-Loss Herbal Intervention Therapy for Obesity. PMID:31680953
Erxian Decoction Attenuates TNF-α Induced Osteoblast Apoptosis by Modulating the Akt/Nrf2/HO-1 Signaling Pathway. PMID:31551787
Molecular Docking: Shifting Paradigms in Drug Discovery. PMID:31487867
Drug-Target Interaction Prediction Based on Drug Fingerprint Information and Protein Sequence. PMID:31430892
The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology. PMID:31412658
Comparison of Target Features for Predicting Drug-Target Interactions by Deep Neural Network Based on Large-Scale Drug-Induced Transcriptome Data. PMID:31382356
A Systems Pharmacology-Based Study of the Molecular Mechanisms of San Cao Decoction for Treating Hypertension. PMID:31354853
Identify the Key Active Ingredients and Pharmacological Mechanisms of Compound XiongShao Capsule in Treating Diabetic Peripheral Neuropathy by Network Pharmacology Approach. PMID:31210774
Molecular mechanisms involved in drug-induced liver injury caused by urate-lowering Chinese herbs: A network pharmacology study and biology experiments. PMID:31141540
Systematically Characterize the Anti-Alzheimer's Disease Mechanism of Lignans from S. chinensis based on In-Vivo Ingredient Analysis and Target-Network Pharmacology Strategy by UHPLC⁻Q-TOF-MS. PMID:30934777
Identification of Cancer Hallmarks Based on the Gene Co-expression Networks of Seven Cancers. PMID:30838028
CSgator: an integrated web platform for compound set analysis. PMID:30830479
Driver network as a biomarker: systematic integration and network modeling of multi-omics data to derive driver signaling pathways for drug combination prediction. PMID:30768150
A Novel Discovery: Holistic Efficacy at the Special Organ Level of Pungent Flavored Compounds from Pungent Traditional Chinese Medicine. PMID:30754631
A Network Pharmacology Analysis to Explore the Effect of Astragali Radix-Radix Angelica Sinensis on Traumatic Brain Injury. PMID:30596090
YaTCM: Yet another Traditional Chinese Medicine Database for Drug Discovery. PMID:30546860
Anti-Inflammatory Effect of a TCM Formula Li-Ru-Kang in Rats With Hyperplasia of Mammary Gland and the Underlying Biological Mechanisms. PMID:30524280
Exploring Pharmacological Mechanisms of Xuefu Zhuyu Decoction in the Treatment of Traumatic Brain Injury via a Network Pharmacology Approach. PMID:30402137
Synergism of antihypertensives and cholinesterase inhibitors in Alzheimer's disease. PMID:30386819
Computational resources associating diseases with genotypes, phenotypes and exposures. PMID:30102366
ADReCS-Target: target profiles for aiding drug safety research and application. PMID:30053268
Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer's Disease. PMID:30050590
Hepatoprotective Effect of San-Cao Granule on Con A-Induced Liver Injury in Mice and Mechanisms of Action Exploration. PMID:29946260
Changing Trends in Computational Drug Repositioning. PMID:29874824
Network-based machine learning and graph theory algorithms for precision oncology. PMID:29872707
DR2DI: a powerful computational tool for predicting novel drug-disease associations. PMID:29687309
Docking-based inverse virtual screening: methods, applications, and challenges. PMID:29577065
Screening for Biologically Annotated Drugs That Trigger Triacylglycerol Accumulation in the Diatom Phaeodactylum. PMID:29535162
Bioinformatics analysis of gene expression alterations conferring drug resistance in tumor samples from melanoma patients with EGFR-activating BRAF mutations. PMID:29387237
A census of P. longum's phytochemicals and their network pharmacological evaluation for identifying novel drug-like molecules against various diseases, with a special focus on neurological disorders. PMID:29320554
Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. PMID:29140520
Mathematical modeling and computational prediction of cancer drug resistance. PMID:28981626
Evidence-Based Precision Oncology with the Cancer Targetome. PMID:28964549
NiaoDuQing granules relieve chronic kidney disease symptoms by decreasing renal fibrosis and anemia. PMID:28915563
From malaria to cancer: Computational drug repositioning of amodiaquine using PLIP interaction patterns. PMID:28900272
In silico prediction of drug-target interaction networks based on drug chemical structure and protein sequences. PMID:28894115
Synergic Anti-Pruritus Mechanisms of Action for the Radix Sophorae Flavescentis and Fructus Cnidii Herbal Pair. PMID:28869563
The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. PMID:28861175
Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors. PMID:28858300
Cell Surface Proteomics of N-Linked Glycoproteins for Typing of Human Lymphocytes. PMID:28834292
Prediction of Drug-Target Interaction Networks from the Integration of Protein Sequences and Drug Chemical Structures. PMID:28678206
Network mirroring for drug repositioning. PMID:28539121
Use of Graph Database for the Integration of Heterogeneous Biological Data. PMID:28416946
CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice. PMID:28296354
Characterization of cytokinome landscape for clinical responses in human cancers. PMID:27999736
A comprehensive map of molecular drug targets. PMID:27910877
Identification of MYST3 as a novel epigenetic activator of ERα frequently amplified in breast cancer. PMID:27893709
Systems pharmacology exploration of botanic drug pairs reveals the mechanism for treating different diseases. PMID:27841365
Large-scale identification of adverse drug reaction-related proteins through a random walk model. PMID:27805066
A small molecule screening to detect potential therapeutic targets in human podocytes. PMID:27760769
Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers. PMID:27694828
New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells. PMID:27626687
BioTriangle: a web-accessible platform for generating various molecular representations for chemicals, proteins, DNAs/RNAs and their interactions. PMID:27330567
DrugQuest - a text mining workflow for drug association discovery. PMID:27295093
A network pharmacology approach to discover active compounds and action mechanisms of San-Cao Granule for treatment of liver fibrosis. PMID:26929602
Essential proteins and possible therapeutic targets of Wolbachia endosymbiont and development of FiloBase--a comprehensive drug target database for Lymphatic filariasis. PMID:26806463
Integrative bioinformatic analyses of an oncogenomic profile reveal the biology of endometrial cancer and guide drug discovery. PMID:26716509
Prediction of Druggable Proteins Using Machine Learning and Systems Biology: A Mini-Review. PMID:26696900
Ambiguity of non-systematic chemical identifiers within and between small-molecule databases. PMID:26579214
Potential Compounds for Oral Cancer Treatment: Resveratrol, Nimbolide, Lovastatin, Bortezomib, Vorinostat, Berberine, Pterostilbene, Deguelin, Andrographolide, and Colchicine. PMID:26536350
Systematic analysis of the associations between adverse drug reactions and pathways. PMID:26495310
Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. PMID:26342919
Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets. PMID:26261215
Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM. PMID:26101539
Analysis of Cynandione A's Anti-Ischemic Stroke Effects from Pathways and Protein-Protein Interactome. PMID:25955557
In silico search of energy metabolism inhibitors for alternative leishmaniasis treatments. PMID:25918726
Recognition of chemical entities: combining dictionary-based and grammar-based approaches. PMID:25810767
Repurpose terbutaline sulfate for amyotrophic lateral sclerosis using electronic medical records. PMID:25739475
A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening. PMID:25165489
Potential therapeutic targets for oral cancer: ADM, TP53, EGFR, LYN, CTLA4, SKIL, CTGF, CD70. PMID:25029526
VNP: Interactive Visual Network Pharmacology of Diseases, Targets, and Drugs. PMID:24622768
Navigating the multilayered organization of eukaryotic signaling: a new trend in data integration. PMID:24550716
Combining heterogenous data for prediction of disease related and pharmacogenes. PMID:24297559
Exploring drug-target interaction networks of illicit drugs. PMID:24268016
Prediction of effective drug combinations by chemical interaction, protein interaction and target enrichment of KEGG pathways. PMID:24083237
DrugMap Central: an on-line query and visualization tool to facilitate drug repositioning studies. PMID:23681121
Leveraging concept-based approaches to identify potential phyto-therapies. PMID:23665360
Identification and characterization of potential therapeutic candidates in emerging human pathogen Mycobacterium abscessus: a novel hierarchical in silico approach. PMID:23527108
CancerDR: cancer drug resistance database. PMID:23486013
Interaction of herbal compounds with biological targets: a case study with berberine. PMID:23213296
Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication. PMID:23168537
Computational drug discovery. PMID:22922346
A strategy based on protein-protein interface motifs may help in identifying drug off-targets. PMID:22817115
Prediction of chemical-protein interactions network with weighted network-based inference method. PMID:22815915
A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data. PMID:22666371
Relax with CouchDB--into the non-relational DBMS era of bioinformatics. PMID:22609849
A genome-wide study of cytogenetic changes in colorectal cancer using SNP microarrays: opportunities for future personalized treatment. PMID:22363777
Prediction of drug combinations by integrating molecular and pharmacological data. PMID:22219721
STITCH 3: zooming in on protein-chemical interactions. PMID:22075997
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. PMID:22002653
Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. PMID:21948793
Bioinformatics and systems biology of the lipidome. PMID:21939287
Identifying compound-target associations by combining bioactivity profile similarity search and public databases mining. PMID:21834535
HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization. PMID:21760913
Software and resources for computational medicinal chemistry. PMID:21707404
Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds. PMID:21569515
Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case study. PMID:21483481
Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions. PMID:21303559
Mapping tissue-specific expression of extracellular proteins using systematic glycoproteomic analysis of different mouse tissues. PMID:20828161
Systems approaches to polypharmacology and drug discovery. PMID:20443163
Identifying unexpected therapeutic targets via chemical-protein interactome. PMID:20221449
DIGA--a database of improved gene annotation for phytopathogens. PMID:20089203
Update of TTD: Therapeutic Target Database. PMID:19933260
Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins. PMID:19785456
Identification of N-glycan serum markers associated with hepatocellular carcinoma from mass spectrometry data. PMID:19764807
Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome. PMID:19629158
Perturbation of interaction networks for application to cancer therapy. PMID:19390668
Drug-therapy networks and the prediction of novel drug targets. PMID:18710588
Searching the Tritryp genomes for drug targets. PMID:18365664
PDTD: a web-accessible protein database for drug target identification. PMID:18282303
STITCH: interaction networks of chemicals and proteins. PMID:18084021
DrugBank: a knowledgebase for drugs, drug actions and drug targets. PMID:18048412
SuperTarget and Matador: resources for exploring drug-target relationships. PMID:17942422
Prediction of potential drug targets based on simple sequence properties. PMID:17883836
A network-based method for target selection in metabolic networks. PMID:17463022
Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. PMID:17244347
PharmGED: Pharmacogenetic Effect Database. PMID:17151074
TarFisDock: a web server for identifying drug targets with docking approach. PMID:16844997
DrugBank: a comprehensive resource for in silico drug discovery and exploration. PMID:16381955
Genome-wide characterisation of the binding repertoire of small molecule drugs. PMID:15601532
ONCOMINE: a cancer microarray database and integrated data-mining platform. PMID:15068665 -
Update of TTD: Therapeutic Target Database
PubMed citations: 99.
99 articles citing: Update of TTD: Therapeutic Target Database
Network pharmacology and bioinformatics analysis identified essential genes of Jingulian in the treatment of rheumatoid arthritis and COVID-19. PMID:35813340
Exploration of the System-Level Mechanisms of the Herbal Drug FDY003 for Pancreatic Cancer Treatment: A Network Pharmacological Investigation. PMID:35591866
Application of Transcriptomics for Predicting Protein Interaction Networks, Drug Targets and Drug Candidates. PMID:35356062
Machine learning prediction of antiviral-HPV protein interactions for anti-HPV pharmacotherapy. PMID:34934067
Mechanism of Fei-Xian Formula in the Treatment of Pulmonary Fibrosis on the Basis of Network Pharmacology Analysis Combined with Molecular Docking Validation. PMID:34394391
Machine learning approaches for drug combination therapies. PMID:34368832
Network Pharmacological Analysis and Experimental Validation of the Mechanisms of Action of Si-Ni-San Against Liver Fibrosis. PMID:34276360
An Ensemble Learning-Based Method for Inferring Drug-Target Interactions Combining Protein Sequences and Drug Fingerprints. PMID:33987446
A Network Pharmacology-Based Approach to Investigating the Mechanisms of Fushen Granule Effects on Intestinal Barrier Injury in Chronic Renal Failure. PMID:33747100
PreDTIs: prediction of drug-target interactions based on multiple feature information using gradient boosting framework with data balancing and feature selection techniques. PMID:33709119
Uncovering the Anti-Lung-Cancer Mechanisms of the Herbal Drug FDY2004 by Network Pharmacology. PMID:33628308
A Network Pharmacology Study on the Molecular Mechanisms of FDY003 for Breast Cancer Treatment. PMID:33628298
Genome announcement of Steinernema khuongi and its associated symbiont from Florida. PMID:33624756
An efficient computational method for predicting drug-target interactions using weighted extreme learning machine and speed up robot features. PMID:33472664
An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak-Gamcho Decoction: A Network Pharmacology Study. PMID:33343676
Mechanism of Action of Bu-Fei-Yi-Shen Formula in Treating Chronic Obstructive Pulmonary Disease Based on Network Pharmacology Analysis and Molecular Docking Validation. PMID:33313323
Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning. PMID:32967266
Predicting novel drugs for SARS-CoV-2 using machine learning from a >10 million chemical space. PMID:32802980
Computational advances of tumor marker selection and sample classification in cancer proteomics. PMID:32802273
Virus-CKB: an integrated bioinformatics platform and analysis resource for COVID-19 research. PMID:32715315
Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling. PMID:32663517
Ingredients, Anti-Liver Cancer Effects and the Possible Mechanism of DWYG Formula Based on Network Prediction. PMID:32523357
An Integrated Pharmacology-Based Analysis for Antidepressant Mechanism of Chinese Herbal Formula Xiao-Yao-San. PMID:32256358
Network Pharmacology-Based Investigation of the System-Level Molecular Mechanisms of the Hematopoietic Activity of Samul-Tang, a Traditional Korean Herbal Formula. PMID:32104198
Exploring Integrative Analysis Using the BioMedical Evidence Graph. PMID:32097025
Whole Genome Sequencing and Comparative Genomics of Two Nematicidal Bacillus Strains Reveals a Wide Range of Possible Virulence Factors. PMID:31919110
Sequence-Derived Markers of Drug Targets and Potentially Druggable Human Proteins. PMID:31803227
Protein functional annotation of simultaneously improved stability, accuracy and false discovery rate achieved by a sequence-based deep learning. PMID:31504150
Five-Feature Model for Developing the Classifier for Synergistic vs. Antagonistic Drug Combinations Built by XGBoost. PMID:31338106
Effects and possible mechanism of Ruyiping formula application to breast cancer based on network prediction. PMID:30918282
Clinical trials, progression-speed differentiating features and swiftness rule of the innovative targets of first-in-class drugs. PMID:30689717
Biomarker Discovery for Immunotherapy of Pituitary Adenomas: Enhanced Robustness and Prediction Ability by Modern Computational Tools. PMID:30609812
Prediction of GluN2B-CT1290-1310/DAPK1 Interaction by Protein⁻Peptide Docking and Molecular Dynamics Simulation. PMID:30463177
Determining the Balance Between Drug Efficacy and Safety by the Network and Biological System Profile of Its Therapeutic Target. PMID:30429792
A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Ban-Xia-Xie-Xin-Tang. PMID:30410554
Identification of novel immune-relevant drug target genes for Alzheimer's Disease by combining ontology inference with network analysis. PMID:30106219
Discovery of the Consistently Well-Performed Analysis Chain for SWATH-MS Based Pharmacoproteomic Quantification. PMID:29997509
Network-Based Disease Module Discovery by a Novel Seed Connector Algorithm with Pathobiological Implications. PMID:29791871
Assessing the Performances of Protein Function Prediction Algorithms from the Perspectives of Identification Accuracy and False Discovery Rate. PMID:29316706
Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. PMID:29140520
Target-Pathogen: a structural bioinformatic approach to prioritize drug targets in pathogens. PMID:29106651
Prediction of Drug-Target Interaction Networks from the Integration of Protein Sequences and Drug Chemical Structures. PMID:28678206
CVE: an R package for interactive variant prioritisation in precision oncology. PMID:28545463
NOREVA: normalization and evaluation of MS-based metabolomics data. PMID:28525573
CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice. PMID:28296354
Biomolecular Network-Based Synergistic Drug Combination Discovery. PMID:27891522
The Human Kinome Targeted by FDA Approved Multi-Target Drugs and Combination Products: A Comparative Study from the Drug-Target Interaction Network Perspective. PMID:27828998
To Unveil the Molecular Mechanisms of Qi and Blood through Systems Biology-Based Investigation into Si-Jun-Zi-Tang and Si-Wu-Tang formulae. PMID:27677604
Comparison of FDA Approved Kinase Targets to Clinical Trial Ones: Insights from Their System Profiles and Drug-Target Interaction Networks. PMID:27547755
SVM-Prot 2016: A Web-Server for Machine Learning Prediction of Protein Functional Families from Sequence Irrespective of Similarity. PMID:27525735
Negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39. PMID:27324164
Exploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics Study. PMID:27230580
Ambiguity of non-systematic chemical identifiers within and between small-molecule databases. PMID:26579214
PDID: database of molecular-level putative protein-drug interactions in the structural human proteome. PMID:26504143
DMAP: a connectivity map database to enable identification of novel drug repositioning candidates. PMID:26423722
Cancer Driver Log (CanDL): Catalog of Potentially Actionable Cancer Mutations. PMID:26320871
Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets. PMID:26261215
PhIN: A Protein Pharmacology Interaction Network Database. PMID:26225242
Metrabase: a cheminformatics and bioinformatics database for small molecule transporter data analysis and (Q)SAR modeling. PMID:26106450
In silico search of energy metabolism inhibitors for alternative leishmaniasis treatments. PMID:25918726
Properties of protein drug target classes. PMID:25822509
Recognition of chemical entities: combining dictionary-based and grammar-based approaches. PMID:25810767
In silico repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of Schistosoma mansoni. PMID:25569258
Navigating the multilayered organization of eukaryotic signaling: a new trend in data integration. PMID:24550716
Exploring drug-target interaction networks of illicit drugs. PMID:24268016
DGIdb: mining the druggable genome. PMID:24122041
Navigating traditional chinese medicine network pharmacology and computational tools. PMID:23983798
Drug Promiscuity in PDB: Protein Binding Site Similarity Is Key. PMID:23805191
Network pharmacology: a new approach for chinese herbal medicine research. PMID:23762149
Chapter 3: Small molecules and disease. PMID:23300405
Identification of pharmacological targets in amyotrophic lateral sclerosis through genomic analysis of deregulated genes and pathways. PMID:23204922
Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication. PMID:23168537
C²Maps: a network pharmacology database with comprehensive disease-gene-drug connectivity relationships. PMID:23134618
A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment. PMID:22962593
TARGETgene: a tool for identification of potential therapeutic targets in cancer. PMID:22952662
CDA: combinatorial drug discovery using transcriptional response modules. PMID:22905152
DTome: a web-based tool for drug-target interactome construction. PMID:22901092
Mapping between databases of compounds and protein targets. PMID:22821596
Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug. PMID:22748168
Relax with CouchDB--into the non-relational DBMS era of bioinformatics. PMID:22609849
Bioinformatics and variability in drug response: a protein structural perspective. PMID:22552919
UniDrug-target: a computational tool to identify unique drug targets in pathogenic bacteria. PMID:22431985
A genome-wide study of cytogenetic changes in colorectal cancer using SNP microarrays: opportunities for future personalized treatment. PMID:22363777
In-silico studies in Chinese herbal medicines' research: evaluation of in-silico methodologies and phytochemical data sources, and a review of research to date. PMID:22326356
TDR Targets: a chemogenomics resource for neglected diseases. PMID:22116064
DNAtraffic--a new database for systems biology of DNA dynamics during the cell life. PMID:22110027
STITCH 3: zooming in on protein-chemical interactions. PMID:22075997
SuperTarget goes quantitative: update on drug-target interactions. PMID:22067455
Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. PMID:21948793
Bioinformatics and systems biology of the lipidome. PMID:21939287
Identifying compound-target associations by combining bioactivity profile similarity search and public databases mining. PMID:21834535
Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. PMID:21768386
Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions. PMID:21303559
HIT: linking herbal active ingredients to targets. PMID:21097881
DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. PMID:21059682
CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowledge. PMID:20952398
Targeted Therapy Database (TTD): a model to match patient's molecular profile with current knowledge on cancer biology. PMID:20706624
Systems approaches to polypharmacology and drug discovery. PMID:20443163
The 2010 Nucleic Acids Research Database Issue and online Database Collection: a community of data resources. PMID:19965766 -
Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information
PubMed citations: 95.
95 articles citing: Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information
Investigating the structure-activity relationship of marine polycyclic batzelladine alkaloids as promising inhibitors for SARS-CoV-2 main protease (Mpro). PMID:35777088
Insights into the structural peculiarities of the N-terminal and receptor binding domains of the spike protein from the SARS-CoV-2 Omicron variant. PMID:35767919
A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19. PMID:35677070
Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study. PMID:35508082
Conserved protein targets for developing pan-coronavirus drugs based on sequence and 3D structure similarity analyses. PMID:35364304
Computational studies on the interaction of SARS-CoV-2 Omicron SGp RBD with human receptor ACE2, limonin and glycyrrhizic acid. PMID:35247766
Exploring complex and heterogeneous correlations on hypergraph for the prediction of drug-target interactions. PMID:34950907
Investigation on the mechanisms of guiqi huoxue capsule for treating cervical spondylosis based on network pharmacology and molecular docking. PMID:34664825
Systems Pharmacology-Based Precision Therapy and Drug Combination Discovery for Breast Cancer. PMID:34298802
A Systems Approach to Brain Tumor Treatment. PMID:34202449
Target identification among known drugs by deep learning from heterogeneous networks. PMID:34123272
The Synergistic Effects of 5-Aminosalicylic Acid and Vorinostat in the Treatment of Ulcerative Colitis. PMID:34093178
Network pharmacology-based and clinically relevant prediction of active ingredients and potential targets of Chinese herbs on stage IV lung adenocarcinoma patients. PMID:33797608
An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication. PMID:33610792
AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer's drug discovery. PMID:33441136
Network controllability-based algorithm to target personalized driver genes for discovering combinatorial drugs of individual patients. PMID:33434272
An Automated Functional Annotation Pipeline That Rapidly Prioritizes Clinically Relevant Genes for Autism Spectrum Disorder. PMID:33261099
A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. PMID:33156843
Ensemble Learning Prediction of Drug-Target Interactions Using GIST Descriptor Extracted from PSSM-Based Evolutionary Information. PMID:32908888
Virus-CKB: an integrated bioinformatics platform and analysis resource for COVID-19 research. PMID:32715315
A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19. PMID:32676577
Guizhi Fuling Decoction inhibiting the PI3K and MAPK pathways in breast cancer cells revealed by HTS2 technology and systems pharmacology. PMID:32489526
An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid. PMID:32457601
ZiYinHuaTan Recipe Inhibits Cell Proliferation and Promotes Apoptosis in Gastric Cancer by Suppressing PI3K/AKT Pathway. PMID:32382534
Drug repositioning: computational approaches and research examples classified according to the evidence level. PMID:32309593
Selective Inhibition of HDAC1 by Macrocyclic Polypeptide for the Treatment of Glioblastoma: A Binding Mechanistic Analysis Based on Molecular Dynamics. PMID:32219100
Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2. PMID:32194980
Investigating the multi-target pharmacological mechanism of danhong injection acting on unstable angina by combined network pharmacology and molecular docking. PMID:32122353
Exploration of databases and methods supporting drug repurposing: a comprehensive survey. PMID:32055842
A bioinformatics investigation into the pharmacological mechanisms of the effect of the Yinchenhao decoction on hepatitis C based on network pharmacology. PMID:32050950
Network-based prediction of drug-target interactions using an arbitrary-order proximity embedded deep forest. PMID:31971579
PTS: a pharmaceutical target seeker. PMID:31725865
Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics. PMID:31691823
Protein functional annotation of simultaneously improved stability, accuracy and false discovery rate achieved by a sequence-based deep learning. PMID:31504150
VARIDT 1.0: variability of drug transporter database. PMID:31495872
Visualization of drug target interactions in the contexts of pathways and networks with ReactomeFIViz. PMID:31372215
Identification of the gene signature reflecting schizophrenia's etiology by constructing artificial intelligence-based method of enhanced reproducibility. PMID:31350824
AICD: an integrated anti-inflammatory compounds database for drug discovery. PMID:31123286
Auto-Generated Physiological Chain Data for an Ontological Framework for Pharmacology and Mechanism of Action to Determine Suspected Drugs in Cases of Dysuria. PMID:31119651
Optimal control nodes in disease-perturbed networks as targets for combination therapy. PMID:31097707
An Ensemble Strategy to Predict Prognosis in Ovarian Cancer Based on Gene Modules. PMID:31068972
Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets. PMID:31056464
A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data. PMID:30988527
A bioinformatics investigation into the pharmacological mechanisms of the effect of Fufang Danshen on pain based on methodologies of network pharmacology. PMID:30976033
Assessing the Effectiveness of Direct Data Merging Strategy in Long-Term and Large-Scale Pharmacometabonomics. PMID:30842738
Identifying cancer prognostic modules by module network analysis. PMID:30777030
Assessing the public landscape of clinical-stage pharmaceuticals through freely available online databases. PMID:30690196
Clinical trials, progression-speed differentiating features and swiftness rule of the innovative targets of first-in-class drugs. PMID:30689717
Biomarker Discovery for Immunotherapy of Pituitary Adenomas: Enhanced Robustness and Prediction Ability by Modern Computational Tools. PMID:30609812
In silico repositioning of approved drugs against Schistosoma mansoni energy metabolism targets. PMID:30596650
Development and Testing of Druglike Screening Libraries. PMID:30563329
Prediction of GluN2B-CT1290-1310/DAPK1 Interaction by Protein⁻Peptide Docking and Molecular Dynamics Simulation. PMID:30463177
Determining the Balance Between Drug Efficacy and Safety by the Network and Biological System Profile of Its Therapeutic Target. PMID:30429792
A Systems-Level Analysis of Mechanisms of Platycodon grandiflorum Based on A Network Pharmacological Approach. PMID:30388815
Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction. PMID:30232231
SMMDB: a web-accessible database for small molecule modulators and their targets involved in neurological diseases. PMID:30219840
Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles. PMID:30219839
A New Strategy to Uncover the Anticancer Mechanism of Chinese Compound Formula by Integrating Systems Pharmacology and Bioinformatics. PMID:30108661
Identification of novel immune-relevant drug target genes for Alzheimer's Disease by combining ontology inference with network analysis. PMID:30106219
ACGH detects distinct genomic alterations of primary intrahepatic cholangiocarcinomas and matched lymph node metastases and identifies a poor prognosis subclass. PMID:30006612
Discovery of the Consistently Well-Performed Analysis Chain for SWATH-MS Based Pharmacoproteomic Quantification. PMID:29997509
Predicting Adverse Drug Effects from Literature- and Database-Mined Assertions. PMID:29876834
Synthetic Lethality-based Identification of Targets for Anticancer Drugs in the Human Signaling Network. PMID:29855504
Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. PMID:29853970
Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology. PMID:29740162
Systems Pharmacology Based Strategy for Q-Markers Discovery of HuangQin Decoction to Attenuate Intestinal Damage. PMID:29615909
Docking-based inverse virtual screening: methods, applications, and challenges. PMID:29577065
Facilitating Anti-Cancer Combinatorial Drug Discovery by Targeting Epistatic Disease Genes. PMID:29570606
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. PMID:29531354
Assessing the Performances of Protein Function Prediction Algorithms from the Perspectives of Identification Accuracy and False Discovery Rate. PMID:29316706
NutriChem 2.0: exploring the effect of plant-based foods on human health and drug efficacy. PMID:29220436
miRDDCR: a miRNA-based method to comprehensively infer drug-disease causal relationships. PMID:29162848
Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. PMID:29140520
NPASS: natural product activity and species source database for natural product research, discovery and tool development. PMID:29106619
Evidence-Based Precision Oncology with the Cancer Targetome. PMID:28964549
Quantitative and Systems Pharmacology. 1. In Silico Prediction of Drug-Target Interactions of Natural Products Enables New Targeted Cancer Therapy. PMID:28956927
Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights. PMID:28862319
Identifying drug-pathway association pairs based on L1L2,1-integrative penalized matrix decomposition. PMID:28624800
Identifying prognostic signature in ovarian cancer using DirGenerank. PMID:28615526
Large-Scale Prediction of Drug-Target Interaction: a Data-Centric Review. PMID:28577120
DrugSig: A resource for computational drug repositioning utilizing gene expression signatures. PMID:28562632
NOREVA: normalization and evaluation of MS-based metabolomics data. PMID:28525573
Network pharmacology-based and clinically relevant prediction of the active ingredients and potential targets of Chinese herbs in metastatic breast cancer patients. PMID:28212580
Performance Evaluation and Online Realization of Data-driven Normalization Methods Used in LC/MS based Untargeted Metabolomics Analysis. PMID:27958387
Pharos: Collating protein information to shed light on the druggable genome. PMID:27903890
Open Targets: a platform for therapeutic target identification and validation. PMID:27899665
Improvements to PATRIC, the all-bacterial Bioinformatics Database and Analysis Resource Center. PMID:27899627
The Human Kinome Targeted by FDA Approved Multi-Target Drugs and Combination Products: A Comparative Study from the Drug-Target Interaction Network Perspective. PMID:27828998
A machine-learned computational functional genomics-based approach to drug classification. PMID:27695919
MeSHDD: Literature-based drug-drug similarity for drug repositioning. PMID:27678460
Comparison of FDA Approved Kinase Targets to Clinical Trial Ones: Insights from Their System Profiles and Drug-Target Interaction Networks. PMID:27547755
SVM-Prot 2016: A Web-Server for Machine Learning Prediction of Protein Functional Families from Sequence Irrespective of Similarity. PMID:27525735
Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome. PMID:27306862
IDAAPM: integrated database of ADMET and adverse effects of predictive modeling based on FDA approved drug data. PMID:27303447
Exploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics Study. PMID:27230580 -
Therapeutic target database update 2014: a resource for targeted therapeutics
PubMed citations: 51.
51 articles citing: Therapeutic target database update 2014: a resource for targeted therapeutics
DTI-BERT: Identifying Drug-Target Interactions in Cellular Networking Based on BERT and Deep Learning Method. PMID:35754843
Nanocarriers Call the Last Shot in the Treatment of Brain Cancers. PMID:35253549
Combination treatment with cisplatin, paclitaxel and olaparib has synergistic and dose reduction potential in ovarian cancer cells. PMID:34335884
MNBDR: A Module Network Based Method for Drug Repositioning. PMID:33375395
Potential Molecular Mechanisms of Plantain in the Treatment of Gout and Hyperuricemia Based on Network Pharmacology. PMID:33149752
Systems Biology Approaches to Understanding the Human Immune System. PMID:32849587
Virus-CKB: an integrated bioinformatics platform and analysis resource for COVID-19 research. PMID:32715315
Study on the mechanisms of compound Kushen injection for the treatment of gastric cancer based on network pharmacology. PMID:32020871
Natural Product Target Network Reveals Potential for Cancer Combination Therapies. PMID:31214023
Systems Chemical Genetics-Based Drug Discovery: Prioritizing Agents Targeting Multiple/Reliable Disease-Associated Genes as Drug Candidates. PMID:31191604
PheWAS-Based Systems Genetics Methods for Anti-Breast Cancer Drug Discovery. PMID:30781719
MDAD: A Special Resource for Microbe-Drug Associations. PMID:30581775
Drug Repurposing for Japanese Encephalitis Virus Infection by Systems Biology Methods. PMID:30567313
Machine Learning for Drug-Target Interaction Prediction. PMID:30200333
Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs. PMID:30123928
KampoDB, database of predicted targets and functional annotations of natural medicines. PMID:30046160
Add-On therapy with Chinese herb medicine Bo-Er-Ning capsule (BENC) improves outcomes of gastric cancer patients: a randomized clinical trial followed with bioinformatics-assisted mechanism study. PMID:30034946
Potential candidate treatment agents for targeting of cholangiocarcinoma identified by gene expression profile analysis. PMID:29930804
Predicting inhibitory and activatory drug targets by chemically and genetically perturbed transcriptome signatures. PMID:29317676
NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations. PMID:29220444
Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. PMID:29140520
MultitaskProtDB-II: an update of a database of multitasking/moonlighting proteins. PMID:29136215
Drug target ontology to classify and integrate drug discovery data. PMID:29122012
Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway. PMID:28910500
Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights. PMID:28862319
AlzhCPI: A knowledge base for predicting chemical-protein interactions towards Alzheimer's disease. PMID:28542505
Pioneering topological methods for network-based drug-target prediction by exploiting a brain-network self-organization theory. PMID:28453640
The Drug Repurposing Hub: a next-generation drug library and information resource. PMID:28388612
A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility. PMID:28074099
The BioGRID interaction database: 2017 update. PMID:27980099
CART-a chemical annotation retrieval toolkit. PMID:27256313
A Network Pharmacology Approach to Uncover the Pharmacological Mechanism of XuanHuSuo Powder on Osteoarthritis. PMID:27110264
SM-TF: A structural database of small molecule-transcription factor complexes. PMID:27010673
Significant impact of miRNA-target gene networks on genetics of human complex traits. PMID:26927695
The Assessment of the Readiness of Molecular Biomarker-Based Mobile Health Technologies for Healthcare Applications. PMID:26644316
Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information. PMID:26578601
An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases. PMID:26575483
WITHDRAWN--a resource for withdrawn and discontinued drugs. PMID:26553801
Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. PMID:26342919
Systems Approach to targeted and long-acting HIV/AIDS therapy. PMID:26315144
Personalized targeted therapy for esophageal squamous cell carcinoma. PMID:26167067
QSAR Modeling Using Large-Scale Databases: Case Study for HIV-1 Reverse Transcriptase Inhibitors. PMID:26046311
DSigDB: drug signatures database for gene set analysis. PMID:25990557
GLASS: a comprehensive database for experimentally validated GPCR-ligand associations. PMID:25971743
Understanding multicellular function and disease with human tissue-specific networks. PMID:25915600
Clustered distribution of natural product leads of drugs in the chemical space as influenced by the privileged target-sites. PMID:25790752
RASTtk: a modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes. PMID:25666585
Virus-host interactomics: new insights and opportunities for antiviral drug discovery. PMID:25593595
CFam: a chemical families database based on iterative selection of functional seeds and seed-directed compound clustering. PMID:25414339
Predicting cancer prognosis using functional genomics data sets. PMID:25392695
Human cancer databases (review). PMID:25369839 - https://doi.org/10.1093/nar/gkz981
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annotation
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
citation
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
disease
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
drug
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
drug combination effect modeling
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
drug metabolic process
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
enzyme commission number
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
ligand binding domain binding
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
natural product
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
protein structure
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
quantitative structure-activity relationship
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
target
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
polypeptide_region
metasource: Fairsharing.org
version: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
other molecular biology databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
drugs and drug design
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
small molecules
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:56.958597
drug discovery
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:56.958597
drug development
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:56.958597
medicinal chemistry
metasource: bio.tools
version: extracted_at: 2022-11-04T11:33:56.958597
Tags
More detailed information about this field from each metasource.
annotation
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
citation
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
disease
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
drug
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
drug combination effect modeling
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
drug metabolic process
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
enzyme commission number
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
ligand binding domain binding
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
natural product
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
protein structure
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
quantitative structure-activity relationship
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
target
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
polypeptide_region
metasource: Fairsharing.orgversion: FAIRsharing.org: TTD, Therapeutic Target Database; TTD, Therapeutic Target Database; DOI: https://doi.org/10.25504/FAIRsharing.fwzf0w; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
other molecular biology databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
drugs and drug design
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
small molecules
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:56.958597
drug discovery
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:56.958597
drug development
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:56.958597
medicinal chemistry
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:33:56.958597
citation disease drug drug combination effect modeling drug metabolic process enzyme commission number ligand binding domain binding natural product protein structure quantitative structure-activity relationship target polypeptide region molecular biology drug small molecule drug discovery drug development medicinal chemistry
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