FAIRsharing.e4n3an; Last edited: April 26, 2021, 9:26 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

GPCRDB
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:01.533601

gpcrdb
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:01.533601

Other names: GPCRdb, GPCRDB, gpcrdb

The GPCRDB is a molecular-class information system that collects, combines, validates and stores large amounts of heterogenous data on G protein-coupled receptors (GPCRs). The GPCRDB contains data on sequences, ligand binding constants and mutations. In addition, many different types of computationally derived data are stored such as multiple sequence alignments and homology models.

Webpage:

http://gpcrdb.org/

Publications: (14)

Publications
More detailed information about this field from each metasource.

GPCRdb in 2018: adding GPCR structure models and ligands
PMID: 29155946
metasource: Fairsharing.org
version: FAIRsharing.org: GPCRdb; Information system for G protein-coupled receptors; DOI: https://doi.org/10.25504/FAIRsharing.e4n3an; Last edited: April 26, 2021, 9:26 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

GPCRDB information system for G protein-coupled receptors
PMID: 12520006
metasource: Fairsharing.org
version: FAIRsharing.org: GPCRdb; Information system for G protein-coupled receptors; DOI: https://doi.org/10.25504/FAIRsharing.e4n3an; Last edited: April 26, 2021, 9:26 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

GPCRdb: an information system for G protein-coupled receptors
PMID: 26582914
metasource: Fairsharing.org
version: FAIRsharing.org: GPCRdb; Information system for G protein-coupled receptors; DOI: https://doi.org/10.25504/FAIRsharing.e4n3an; Last edited: April 26, 2021, 9:26 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

GPCRDB: an information system for G protein-coupled receptors
PMID: 9399852
metasource: Fairsharing.org
version: FAIRsharing.org: GPCRdb; Information system for G protein-coupled receptors; DOI: https://doi.org/10.25504/FAIRsharing.e4n3an; Last edited: April 26, 2021, 9:26 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

GPCRdb in 2021: integrating GPCR sequence, structure and function
PMID: 33270898
metasource: Fairsharing.org
version: FAIRsharing.org: GPCRdb; Information system for G protein-coupled receptors; DOI: https://doi.org/10.25504/FAIRsharing.e4n3an; Last edited: April 26, 2021, 9:26 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

GPCRDB: information system for G protein-coupled receptors
PMID: 21045054
metasource: Fairsharing.org
version: FAIRsharing.org: GPCRdb; Information system for G protein-coupled receptors; DOI: https://doi.org/10.25504/FAIRsharing.e4n3an; Last edited: April 26, 2021, 9:26 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

GPCRdb: the G protein-coupled receptor database - an introduction
PMID: 27155948
metasource: Fairsharing.org
version: FAIRsharing.org: GPCRdb; Information system for G protein-coupled receptors; DOI: https://doi.org/10.25504/FAIRsharing.e4n3an; Last edited: April 26, 2021, 9:26 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

GPCRDB: an information system for G protein-coupled receptors
PMID: 24304901
metasource: Fairsharing.org
version: FAIRsharing.org: GPCRdb; Information system for G protein-coupled receptors; DOI: https://doi.org/10.25504/FAIRsharing.e4n3an; Last edited: April 26, 2021, 9:26 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

https://doi.org/10.1093/nar/gkaa1080
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

http://dx.doi.org/10.1093/nar/gkv1178
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:01.533601

http://dx.doi.org/10.1093/nar/gkaa1080
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:01.533601

http://dx.doi.org/10.1093/nar/gkx1109
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:01.533601

http://dx.doi.org/10.1038/s41586-020-2888-2
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:01.533601

http://dx.doi.org/10.1038/s41592-018-0302-x
metasource: bio.tools
version: extracted_at: 2022-11-04T11:29:01.533601

GPCRdb in 2018: adding GPCR structure models and ligands PubMed citations: 168.

168 articles citing: GPCRdb in 2018: adding GPCR structure models and ligands

Structural basis of leukotriene B4 receptor 1 activation. PMID:35241677
Two entry tunnels in mouse TAAR9 suggest the possibility of multi-entry tunnels in olfactory receptors. PMID:35177711
Novel NK1R-Targeted 68Ga-/177Lu-Radioconjugates with Potential Application against Glioblastoma Multiforme: Preliminary Exploration of Structure-Activity Relationships. PMID:35163139
Evolution of Brain-Expressed Biogenic Amine Receptors into Olfactory Trace Amine-Associated Receptors. PMID:35021231
Structure-function relationships of the disease-linked A218T oxytocin receptor variant. PMID:34980886
Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling. PMID:34966948
Precise druggability of the PTH type 1 receptor. PMID:34949836
pdCSM-GPCR: predicting potent GPCR ligands with graph-based signatures. PMID:34901870
The Structural Determinants for α1-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives. PMID:34834117
Ligand Docking Methods to Recognize Allosteric Inhibitors for G-Protein-Coupled Receptors. PMID:34733103
Viewpoints on the First Transatlantic GPCR Symposium for Early-Career Investigators. PMID:34661085
Autoencoder-based detection of the residues involved in G protein-coupled receptor signaling. PMID:34615896
Unique features of different classes of G-protein-coupled receptors revealed from sequence coevolutionary and structural analysis. PMID:34599827
Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations. PMID:34576210
The G protein database, GproteinDb. PMID:34570219
Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome. PMID:34522296
Cholesterol Is a Dose-Dependent Positive Allosteric Modulator of CCR3 Ligand Affinity and G Protein Coupling. PMID:34490352
Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor. PMID:34477105
In Silico Identification of Cholesterol Binding Motifs in the Chemokine Receptor CCR3. PMID:34436333
Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations. PMID:34377364
Modeling of CCR5 Recognition by HIV-1 gp120: How the Viral Protein Exploits the Conformational Plasticity of the Coreceptor. PMID:34372601
Ligand-directed bias of G protein signaling at the dopamine D2 receptor. PMID:34302750
Guardians of the Cell: State-of-the-Art of Membrane Proteins from a Computational Point-of-View. PMID:34302667
A molecular sensor for cholesterol in the human serotonin1A receptor. PMID:34301606
Homo-oligomerization of the human adenosine A2A receptor is driven by the intrinsically disordered C-terminus. PMID:34269678
Delineating the Ligand-Receptor Interactions That Lead to Biased Signaling at the μ-Opioid Receptor. PMID:34251810
A two-stage computational approach to predict novel ligands for a chemosensory receptor. PMID:34235481
Mutational Landscape of the Proglucagon-Derived Peptides. PMID:34220721
Uncovering of cytochrome P450 anatomy by SecStrAnnotator. PMID:34117311
Guanidine Derivatives: How Simple Structural Modification of Histamine H3R Antagonists Has Led to the Discovery of Potent Muscarinic M2R/M4R Antagonists. PMID:34100603
Structural insights on ligand recognition at the human leukotriene B4 receptor 1. PMID:34016973
Ocean Acidification Amplifies the Olfactory Response to 2-Phenylethylamine: Altered Cue Reception as a Mechanistic Pathway? PMID:34014453
Pathways and Mechanism of Caffeine Binding to Human Adenosine A2A Receptor. PMID:33987207
Can molecular dynamics simulations improve the structural accuracy and virtual screening performance of GPCR models? PMID:33983933
Biochemical Characterization of GPCR-G Protein Complex Formation. PMID:33877621
Cryo-EM structure of the human histamine H1 receptor/Gq complex. PMID:33828102
Molecular Modeling of Histamine Receptors-Recent Advances in Drug Discovery. PMID:33810008
Unraveling the Molecular Nexus between GPCRs, ERS, and EMT. PMID:33746610
From Pharmacology to Physiology: Endocrine Functions of μ-Opioid Receptor Networks. PMID:33676828
Ecto-GPR37: a potential biomarker for Parkinson's disease. PMID:33637132
Determination of G-protein-coupled receptor oligomerization by molecular brightness analyses in single cells. PMID:33514946
MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants. PMID:33467419
Neuronal Dopamine D3 Receptors: Translational Implications for Preclinical Research and CNS Disorders. PMID:33466844
Evidence that specific interactions play a role in the cholesterol sensitivity of G protein-coupled receptors. PMID:33444621
Dynamical Correlations Reveal Allosteric Sites in G Protein-Coupled Receptors. PMID:33375427
Integration of Cell-Free Expression and Solid-State NMR to Investigate the Dynamic Properties of Different Sites of the Growth Hormone Secretagogue Receptor. PMID:33324203
The Gαi protein subclass selectivity to the dopamine D2 receptor is also decided by their location at the cell membrane. PMID:33308256
Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling. PMID:33288675
GPCRdb in 2021: integrating GPCR sequence, structure and function. PMID:33270898
A2A Adenosine Receptor Partial Agonism Related to Structural Rearrangements in an Activation Microswitch. PMID:33238145
GPCR-PEnDB: a database of protein sequences and derived features to facilitate prediction and classification of G protein-coupled receptors. PMID:33216895
Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs. PMID:33184270
Combinatorial expression of GPCR isoforms affects signalling and drug responses. PMID:33149304
Subtype-selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors. PMID:33122823
Improving homology modeling from low-sequence identity templates in Rosetta: A case study in GPCRs. PMID:33112852
Hybrid MM/CG Webserver: Automatic Set Up of Molecular Mechanics/Coarse-Grained Simulations for Human G Protein-Coupled Receptor/Ligand Complexes. PMID:33102525
Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor. PMID:33101610
Comparative morphological and transcriptomic analyses reveal chemosensory genes in the poultry red mite, Dermanyssus gallinae. PMID:33087814
In Vivo, In Vitro and In Silico Studies of the Hybrid Compound AA3266, an Opioid Agonist/NK1R Antagonist with Selective Cytotoxicity. PMID:33086743
Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable. PMID:33086039
Structural and functional characterization of G protein-coupled receptors with deep mutational scanning. PMID:33084570
Capturing Peptide-GPCR Interactions and Their Dynamics. PMID:33076289
Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl-Simulated Interaction Patterns Confronted with Experimental Data. PMID:33053718
MCCS, a novel characterization method for protein-ligand complex. PMID:33051641
Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats. PMID:33050653
Characterization of five novel vasopressin V2 receptor mutants causing nephrogenic diabetes insipidus reveals a role of tolvaptan for M272R-V2R mutation. PMID:33009446
A Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action. PMID:32970276
GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain. PMID:32913007
Structural biology of human GPCR drugs and endogenous ligands - insights from NMR spectroscopy. PMID:32911074
How Do Molecular Dynamics Data Complement Static Structural Data of GPCRs. PMID:32824756
Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors. PMID:32824729
Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor*. PMID:32794211
CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis. PMID:32792587
The oxytocin receptor signalling system and breast cancer: a critical review. PMID:32782397
Allosteric Molecular Switches in Metabotropic Glutamate Receptors. PMID:32686363
Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch. PMID:32664385
Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling. PMID:32663517
The C-Terminus and Third Cytoplasmic Loop Cooperatively Activate Mouse Melanopsin Phototransduction. PMID:32621866
Mechanism of β-arrestin recruitment by the μ-opioid G protein-coupled receptor. PMID:32601232
Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor. PMID:32555462
Docking of peptides to GPCRs using a combination of CABS-dock with FlexPepDock refinement. PMID:32520310
Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes. PMID:32510327
Advances in therapeutic peptides targeting G protein-coupled receptors. PMID:32494050
Coevolutionary data-based interaction networks approach highlighting key residues across protein families: The case of the G-protein coupled receptors. PMID:32489528
Analysis of Pigment-Dispersing Factor Neuropeptides and Their Receptor in a Velvet Worm. PMID:32477266
A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR. PMID:32371991
Drug Research Meets Network Science: Where Are We? PMID:32338900
The Hydrophobic Ligands Entry and Exit from the GPCR Binding Site-SMD and SuMD Simulations. PMID:32326322
The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling. PMID:32296774
DeepBindPoc: a deep learning method to rank ligand binding pockets using molecular vector representation. PMID:32292649
A Bright and Colorful Future for G-Protein Coupled Receptor Sensors. PMID:32265667
Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation. PMID:32236094
Performance of virtual screening against GPCR homology models: Impact of template selection and treatment of binding site plasticity. PMID:32168319
The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist. PMID:32127473
Ligand-induced conformational changes in a SMALP-encapsulated GPCR. PMID:32126232
N-(2-Hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1H- benzimidazol-1-yl)propyl]piperidine-4-Carboxamide (D2AAK4), a Multi-Target Ligand of Aminergic GPCRs, as a Potential Antipsychotic. PMID:32102432
Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. PMID:32079767
Exploration of databases and methods supporting drug repurposing: a comprehensive survey. PMID:32055842
Preferential Coupling of Dopamine D2S and D2L Receptor Isoforms with Gi1 and Gi2 Proteins-In Silico Study. PMID:31936673
Comparative modeling and docking of chemokine-receptor interactions with Rosetta. PMID:31924303
Common activation mechanism of class A GPCRs. PMID:31855179
Artificial signaling in mammalian cells enabled by prokaryotic two-component system. PMID:31844302
An Integrated Pan-Cancer Analysis and Structure-Based Virtual Screening of GPR15. PMID:31835584
Engineering G protein-coupled receptor signalling in yeast for biotechnological and medical purposes. PMID:31825496
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists. PMID:31807708
A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration. PMID:31790581
N-Palmitoylglycine and other N-acylamides activate the lipid receptor G2A/GPR132. PMID:31768260
Toward G protein-coupled receptor structure-based drug design using X-ray lasers. PMID:31709066
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors. PMID:31675498
Design, Synthesis and Evaluation of New Indolylpyrimidylpiperazines for Gastrointestinal Cancer Therapy. PMID:31614517
International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand. PMID:31492821
A Molecular Dynamics Study of Vasoactive Intestinal Peptide Receptor 1 and the Basis of Its Therapeutic Antagonism. PMID:31491880
The Biological and Clinical Relevance of G Protein-Coupled Receptors to the Outcomes of Hematopoietic Stem Cell Transplantation: A Systematized Review. PMID:31404983
Revisiting the classification of adhesion GPCRs. PMID:31365134
Dicyemid Mesozoans: A Unique Parasitic Lifestyle and a Reduced Genome. PMID:31347665
Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs. PMID:31337749
Protein-protein interaction modulators: advances, successes and remaining challenges. PMID:31301019
Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system. PMID:31299132
VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells. PMID:31280962
Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit. PMID:31251171
Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR. PMID:31249143
In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR. PMID:31244651
SeQuery: an interactive graph database for visualizing the GPCR superfamily. PMID:31236561
An outlook on using serial femtosecond crystallography in drug discovery. PMID:31184514
Utilization of Biased G Protein-Coupled ReceptorSignaling towards Development of Safer andPersonalized Therapeutics. PMID:31146474
Variable G protein determinants of GPCR coupling selectivity. PMID:31142646
Understanding Ligand Binding to G-Protein Coupled Receptors Using Multiscale Simulations. PMID:31131282
A benchmark study of loop modeling methods applied to G protein-coupled receptors. PMID:31123958
Function-related conformational dynamics of G protein-coupled receptors revealed by NMR. PMID:31102199
Uterine Gαq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse. PMID:31091422
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. PMID:31073061
Structural basis of ligand recognition at the human MT1 melatonin receptor. PMID:31019306
A Metadynamics-Based Protocol for the Determination of GPCR-Ligand Binding Modes. PMID:31013635
Interfacial Binding Sites for Cholesterol on G Protein-Coupled Receptors. PMID:31010663
Evaluating the performance of MM/PBSA for binding affinity prediction using class A GPCR crystal structures. PMID:30989574
Role of Helix 8 in Dopamine Receptor Signaling. PMID:30971061
Prediction and expression analysis of G protein-coupled receptors in the laboratory stick insect, Carausius morosus. PMID:30930638
Beyond the Flavour: The Potential Druggability of Chemosensory G Protein-Coupled Receptors. PMID:30897734
Structural insight into the serotonin (5-HT) receptor family by molecular docking, molecular dynamics simulation and systems pharmacology analysis. PMID:30814658
Open-Boundary Molecular Mechanics/Coarse-Grained Framework for Simulations of Low-Resolution G-Protein-Coupled Receptor-Ligand Complexes. PMID:30763087
Cellular signalling by primary cilia in development, organ function and disease. PMID:30733609
An online resource for GPCR structure determination and analysis. PMID:30664776
Modeling the complete chemokine-receptor interaction. PMID:30616825
Solution NMR spectroscopy of GPCRs: Residue-specific labeling strategies with a focus on 13C-methyl methionine labeling of the atypical chemokine receptor ACKR3. PMID:30616824
Measuring surface expression and endocytosis of GPCRs using whole-cell ELISA. PMID:30616815
Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation. PMID:30601679
G protein-coupled receptors in arthropod vectors: omics and pharmacological approaches to elucidate ligand-receptor interactions and novel organismal functions. PMID:30551818
Coupling of Human Rhodopsin to a Yeast Signaling Pathway Enables Characterization of Mutations Associated with Retinal Disease. PMID:30514708
Binding of histamine to the H1 receptor-a molecular dynamics study. PMID:30498974
The MemProtMD database: a resource for membrane-embedded protein structures and their lipid interactions. PMID:30418645
GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures. PMID:30410121
BitterDB: taste ligands and receptors database in 2019. PMID:30357384
Life beyond the Tanimoto coefficient: similarity measures for interaction fingerprints. PMID:30288626
Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands. PMID:30285606
Emerging structural biology of lipid G protein-coupled receptors. PMID:30239054
On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies. PMID:30121871
SynPharm: A Guide to PHARMACOLOGY Database Tool for Designing Drug Control into Engineered Proteins. PMID:30087931
PAC1 Receptors: Shapeshifters in Motion. PMID:30074173
Reprogramming G protein coupled receptor structure and function. PMID:30055347
The F238L Point Mutation in the Cannabinoid Type 1 Receptor Enhances Basal Endocytosis via Lipid Rafts. PMID:30026687
Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling. PMID:30021154
Computational design of thermostabilizing point mutations for G protein-coupled receptors. PMID:29927385
Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor. PMID:29874058
Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish. PMID:29793939
GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models. PMID:29788177
3D-e-Chem: Structural Cheminformatics Workflows for Computer-Aided Drug Discovery. PMID:29337438
The 2018 Nucleic Acids Research database issue and the online molecular biology database collection. PMID:29316735
Pharmacogenomics of GPCR Drug Targets. PMID:29249361
GPCRDB information system for G protein-coupled receptors PubMed citations: 112.

112 articles citing: GPCRDB information system for G protein-coupled receptors

What Makes GPCRs from Different Families Bind to the Same Ligand? PMID:35883418
G-Protein coupled receptors: structure and function in drug discovery. PMID:35517958
G Protein-Coupled Receptors in Taste Physiology and Pharmacology. PMID:33390961
Molecular cloning and expression analysis of mc5r like genes (mc5rl) in Ruditapes philippinarum (Manila clam) after aerial exposure and low-temperature stress. PMID:33128687
Dual binding mode of "bitter sugars" to their human bitter taste receptor target. PMID:31186454
GPCR-SAS: A web application for statistical analyses on G protein-coupled receptors sequences. PMID:30044824
Experiences with Deriva: An Asset Management Platform for Accelerating eScience. PMID:29756001
Apelinergic System Structure and Function. PMID:29357134
Structural Analysis of Chemokine Receptor-Ligand Interactions. PMID:28165741
A Method for the Annotation of Functional Similarities of Coding DNA Sequences: the Case of a Populated Cluster of Transmembrane Proteins. PMID:27812751
Prediction of G Protein-Coupled Receptors with SVM-Prot Features and Random Forest. PMID:27529053
Genome and Transcriptome Sequences Reveal the Specific Parasitism of the Nematophagous Purpureocillium lilacinum 36-1. PMID:27486440
GPCRdb: the G protein-coupled receptor database - an introduction. PMID:27155948
GPCRdb: an information system for G protein-coupled receptors. PMID:26582914
Generic GPCR residue numbers - aligning topology maps while minding the gaps. PMID:25541108
GPCRsort-responding to the next generation sequencing data challenge: prediction of G protein-coupled receptor classes using only structural region lengths. PMID:25133496
Alpha-bulges in G protein-coupled receptors. PMID:24806342
Current progress in Structure-Based Rational Drug Design marks a new mindset in drug discovery. PMID:24688704
GPCRDB: an information system for G protein-coupled receptors. PMID:24304901
Do plants contain g protein-coupled receptors? PMID:24246381
GPCR ontology: development and application of a G protein-coupled receptor pharmacology knowledge framework. PMID:24078711
Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor. PMID:23935897
Identification of novel arthropod vector G protein-coupled receptors. PMID:23705687
Observations on the evolution of the melanocortin receptor gene family: distinctive features of the melanocortin-2 receptor. PMID:23596380
Structure-based network analysis of an evolved G protein-coupled receptor homodimer interface. PMID:23553730
Receptor-mediated signaling in Aspergillus fumigatus. PMID:23430083
Large multiple transmembrane domain fragments of a G protein-coupled receptor: biosynthesis, purification, and biophysical studies. PMID:23203693
Novel RNAi-mediated approach to G protein-coupled receptor deorphanization: proof of principle and characterization of a planarian 5-HT receptor. PMID:22815820
Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling. PMID:22429589
Drug design for ever, from hype to hope. PMID:22252446
The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterranea. PMID:22145649
Not all transmembrane helices are born equal: Towards the extension of the sequence homology concept to membrane proteins. PMID:22024092
Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs). PMID:21852241
ss-TEA: Entropy based identification of receptor specific ligand binding residues from a multiple sequence alignment of class A GPCRs. PMID:21831265
Large-scale RNAi screen of G protein-coupled receptors involved in larval growth, molting and metamorphosis in the red flour beetle. PMID:21806814
Polymer-based cell-free expression of ligand-binding family B G-protein coupled receptors without detergents. PMID:21465615
The G protein-coupled receptors in the pufferfish Takifugu rubripes. PMID:21342560
Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis. PMID:21214938
GPCRDB: information system for G protein-coupled receptors. PMID:21045054
GPCRRD: G protein-coupled receptor spatial restraint database for 3D structure modeling and function annotation. PMID:20926423
GPCRs, G-proteins, effectors and their interactions: human-gpDB, a database employing visualization tools and data integration techniques. PMID:20689020
Lessons from free energy simulations of delta-opioid receptor homodimers involving the fourth transmembrane helix. PMID:20617813
A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization. PMID:20537162
Systematic generation of in vivo G protein-coupled receptor mutants in the rat. PMID:20531371
GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. PMID:20501551
Prediction of functional class of proteins and peptides irrespective of sequence homology by support vector machines. PMID:20066123
Cone photoreceptor mosaic disruption associated with Cys203Arg mutation in the M-cone opsin. PMID:19934058
Phe369(7.38) at human 5-HT(7) receptors confers interspecies selectivity to antagonists and partial agonists. PMID:19922537
MeMotif: a database of linear motifs in alpha-helical transmembrane proteins. PMID:19910368
Exploring molecular mechanisms of ligand recognition by opioid receptors with metadynamics. PMID:19785461
A survey of integral alpha-helical membrane proteins. PMID:19760129
Improved mutation tagging with gene identifiers applied to membrane protein stability prediction. PMID:19758467
Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models. PMID:19756152
Homology modelling and spectroscopy, a never-ending love story. PMID:19718498
Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors. PMID:19672320
Modern homology modeling of G-protein coupled receptors: which structural template to use? PMID:19627087
Hmrbase: a database of hormones and their receptors. PMID:19589147
7TMRmine: a Web server for hierarchical mining of 7TMR proteins. PMID:19538753
The repertoire of G-protein-coupled receptors in Xenopus tropicalis. PMID:19508718
The structure and function of G-protein-coupled receptors. PMID:19458711
Site specificity of agonist and second messenger-activated kinases for somatostatin receptor subtype 2A (Sst2A) phosphorylation. PMID:19389921
Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors. PMID:19262747
Computational study of the heterodimerization between mu and delta receptors. PMID:19214754
Conserved rhodopsin intradiscal structural motifs mediate stabilization: effects of zinc. PMID:19206210
IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. PMID:18948278
SDR: a database of predicted specificity-determining residues in proteins. PMID:18927118
Discovery and validation of novel peptide agonists for G-protein-coupled receptors. PMID:18854305
TMFunction: database for functional residues in membrane proteins. PMID:18842639
Virtual screening of GPCRs: an in silico chemogenomics approach. PMID:18775075
GPCRTree: online hierarchical classification of GPCR function. PMID:18717986
Whole proteome identification of plant candidate G-protein coupled receptors in Arabidopsis, rice, and poplar: computational prediction and in-vivo protein coupling. PMID:18671868
GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. PMID:18533035
The repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis. PMID:18452600
Modelling the structures of G protein-coupled receptors aided by three-dimensional validation. PMID:18315845
Prediction of functional nonsynonymous single nucleotide polymorphisms in human G-protein-coupled receptors. PMID:18299956
Na/H exchange regulatory factor 1, a novel AKT-associating protein, regulates extracellular signal-regulated kinase signaling through a B-Raf-mediated pathway. PMID:18272783
Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors. PMID:18256283
Gene characterization index: assessing the depth of gene annotation. PMID:18213364
GLIDA: GPCR--ligand database for chemical genomics drug discovery--database and tools update. PMID:17986454
Agonist-dependent cannabinoid receptor signalling in human trabecular meshwork cells. PMID:17922024
Automated protein subfamily identification and classification. PMID:17708678
New insights into human prostacyclin receptor structure and function through natural and synthetic mutations of transmembrane charged residues. PMID:17704830
Affinity purification and characterization of a G-protein coupled receptor, Saccharomyces cerevisiae Ste2p. PMID:17646109
Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. PMID:17537266
Arginine (CGC) codon targeting in the human prostacyclin receptor gene (PTGIR) and G-protein coupled receptors (GPCR). PMID:17481829
Role of group-conserved residues in the helical core of beta2-adrenergic receptor. PMID:17438264
Membrane protein prediction methods. PMID:17367718
Using a pharmacophore representation concept to elucidate molecular similarity of dopamine antagonists. PMID:17295120
RINGdb: an integrated database for G protein-coupled receptors and regulators of G protein signaling. PMID:17173697
Mining the Arabidopsis thaliana genome for highly-divergent seven transmembrane receptors. PMID:17064408
Development and application of hybrid structure based method for efficient screening of ligands binding to G-protein coupled receptors. PMID:17054015
A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation. PMID:16879811
Corticotropin releasing hormone and the skin. PMID:16720310
Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization. PMID:16634642
Prediction of indirect interactions in proteins. PMID:16553946
GLIDA: GPCR-ligand database for chemical genomic drug discovery. PMID:16381956
Homology modeling of opioid receptor-ligand complexes using experimental constraints. PMID:16353922
Molecular dynamics simulations of bovine rhodopsin: influence of protonation states and different membrane-mimicking environments. PMID:16247601
GRIFFIN: a system for predicting GPCR-G-protein coupling selectivity using a support vector machine and a hidden Markov model. PMID:15980445
A method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov Models. PMID:15847681
Sequence variation in G-protein-coupled receptors: analysis of single nucleotide polymorphisms. PMID:15784611
Novel G-protein-coupled receptor-like proteins in the plant pathogenic fungus Magnaporthe grisea. PMID:15774025
Critical evaluation of the JDO API for the persistence and portability requirements of complex biological databases. PMID:15642112
A database for G proteins and their interaction with GPCRs. PMID:15619328
Lower rate of genomic variation identified in the trans-membrane domain of monoamine sub-class of Human G-Protein Coupled Receptors: the Human GPCR-DB Database. PMID:15579207
Modeling and simulation of the human delta opioid receptor. PMID:15238638
PRED-GPCR: GPCR recognition and family classification server. PMID:15215415
The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. PMID:15155892
Identification of core amino acids stabilizing rhodopsin. PMID:15123809
Ser and Thr residues modulate the conformation of pro-kinked transmembrane alpha-helices. PMID:14695254
WU-Blast2 server at the European Bioinformatics Institute. PMID:12824421
A comparison of Pfam and MEROPS: two databases, one comprehensive, and one specialised. PMID:12740029
GPCRdb: an information system for G protein-coupled receptors PubMed citations: 107.

107 articles citing: GPCRdb: an information system for G protein-coupled receptors

Structure Prediction, Evaluation, and Validation of GPR18 Lipid Receptor Using Free Programs. PMID:35887268
Exploring the kinetic selectivity of drugs targeting the β1 -adrenoceptor. PMID:35762357
Cancer-Related Somatic Mutations in Transmembrane Helices Alter Adenosine A1 Receptor Pharmacology. PMID:35744872
Building the Chordata Olfactory Receptor Database using more than 400,000 receptors annotated by Genome2OR. PMID:35696018
Substituted Purines as High-Affinity Histamine H3 Receptor Ligands. PMID:35631399
The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites. PMID:35538063
The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor. PMID:35495622
Mechanism of Peptide Agonist Binding in CXCR4 Chemokine Receptor. PMID:35359589
Two entry tunnels in mouse TAAR9 suggest the possibility of multi-entry tunnels in olfactory receptors. PMID:35177711
Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery. PMID:35056070
Molecular basis for the evolved instability of a human G-protein coupled receptor. PMID:34818554
Molecular and in vivo phenotyping of missense variants of the human glucagon receptor. PMID:34801547
Unique features of different classes of G-protein-coupled receptors revealed from sequence coevolutionary and structural analysis. PMID:34599827
2D SIFt: a matrix of ligand-receptor interactions. PMID:34496955
Homology Modeling of Class A G-Protein-Coupled Receptors in the Age of the Structure Boom. PMID:34302671
Motions around conserved helical weak spots facilitate GPCR activation. PMID:34272892
GPCRs: The most promiscuous druggable receptor of the mankind. PMID:34194261
Asymmetric activation of the calcium-sensing receptor homodimer. PMID:34194040
Unlocking the Non-IgE-Mediated Pseudo-Allergic Reaction Puzzle with Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2). PMID:33925682
PyPLIF HIPPOS-Assisted Prediction of Molecular Determinants of Ligand Binding to Receptors. PMID:33922338
Coevolution underlies GPCR-G protein selectivity and functionality. PMID:33846507
GPCRdb in 2021: integrating GPCR sequence, structure and function. PMID:33270898
Improving homology modeling from low-sequence identity templates in Rosetta: A case study in GPCRs. PMID:33112852
Structural and functional characterization of G protein-coupled receptors with deep mutational scanning. PMID:33084570
Activation of GPR56, a novel adhesion GPCR, is necessary for nuclear androgen receptor signaling in prostate cells. PMID:32881870
Pathway and mechanism of drug binding to chemokine receptors revealed by accelerated molecular simulations. PMID:32515227
A Bitter Taste in Your Heart. PMID:32457649
PyRod Enables Rational Homology Model-based Virtual Screening Against MCHR1. PMID:32329245
The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling. PMID:32296774
Lipid-Protein Interactions Are a Unique Property and Defining Feature of G Protein-Coupled Receptors. PMID:32272057
A Taxicab geometry quantification system to evaluate the performance of in silico methods: a case study on adenosine receptors ligands. PMID:32112287
Characterizing Interhelical Interactions of G-Protein Coupled Receptors with the Fragment Molecular Orbital Method. PMID:32096994
Common activation mechanism of class A GPCRs. PMID:31855179
Unraveling allosteric landscapes of allosterome with ASD. PMID:31665428
Prediction of Conformation Specific Thermostabilizing Mutations for Class A G Protein-Coupled Receptors. PMID:31408606
Mechanistic Insights into Specific G Protein Interactions with Adenosine Receptors. PMID:31283874
Influence of the Structural Accuracy of Homology Models on Their Applicability to Docking-Based Virtual Screening: The β2 Adrenergic Receptor as a Case Study. PMID:31257873
Dual binding mode of "bitter sugars" to their human bitter taste receptor target. PMID:31186454
PRECOG: PREdicting COupling probabilities of G-protein coupled receptors. PMID:31143927
Pharmacology and function of the orphan GPR139 G protein-coupled receptor. PMID:31132229
Structural basis of ligand recognition at the human MT1 melatonin receptor. PMID:31019306
Recognition of repulsive and attractive regions of selected serotonin receptor binding site using FMO-EDA approach. PMID:30955095
Computer aided protein engineering to enhance the thermo-stability of CXCR1- T4 lysozyme complex. PMID:30926935
Significantly different effects of tetrahydroberberrubine enantiomers on dopamine D1/D2 receptors revealed by experimental study and integrated in silico simulation. PMID:30840169
Open-Boundary Molecular Mechanics/Coarse-Grained Framework for Simulations of Low-Resolution G-Protein-Coupled Receptor-Ligand Complexes. PMID:30763087
Emerging Diversity in Lipid-Protein Interactions. PMID:30758191
Diverse GPCRs exhibit conserved water networks for stabilization and activation. PMID:30728297
An online resource for GPCR structure determination and analysis. PMID:30664776
GPCR homology model template selection benchmarking: Global versus local similarity measures. PMID:30390544
Analysis of impact metrics for the Protein Data Bank. PMID:30325351
Exploring a new ligand binding site of G protein-coupled receptors. PMID:30310578
GPCR-SAS: A web application for statistical analyses on G protein-coupled receptors sequences. PMID:30044824
Compound Ranking Based on Fuzzy Three-Dimensional Similarity Improves the Performance of Docking into Homology Models of G-Protein-Coupled Receptors. PMID:30023670
G protein-coupled receptors: the evolution of structural insight. PMID:29951585
Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go. PMID:29925951
Identification of natural products as novel ligands for the human 5-HT2C receptor. PMID:29577069
Kinase inhibitors: the road ahead. PMID:29545548
Serial Femtosecond Crystallography of G Protein-Coupled Receptors. PMID:29543504
In Silico Studies Targeting G-protein Coupled Receptors for Drug Research Against Parkinson's Disease. PMID:29521236
Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor. PMID:29402888
5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. PMID:29398112
3D-e-Chem: Structural Cheminformatics Workflows for Computer-Aided Drug Discovery. PMID:29337438
Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas. PMID:29335563
Bacterial endosymbionts influence host sexuality and reveal reproductive genes of early divergent fungi. PMID:29184190
GPCRdb in 2018: adding GPCR structure models and ligands. PMID:29155946
Visualizing the GPCR Network: Classification and Evolution. PMID:29138525
Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors. PMID:29125553
Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding. PMID:29123501
Genes encoding neuropeptide receptors are epigenetic markers in patients with head and neck cancer: a site-specific analysis. PMID:29100314
Trends in GPCR drug discovery: new agents, targets and indications. PMID:29075003
Applications of sequence coevolution in membrane protein biochemistry. PMID:28993150
TM-Aligner: Multiple sequence alignment tool for transmembrane proteins with reduced time and improved accuracy. PMID:28970546
Using random forests for assistance in the curation of G-protein coupled receptor databases. PMID:28830426
Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A3 Receptor Antagonists. PMID:28806076
The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket. PMID:28798468
Methods for the Development of In Silico GPCR Models. PMID:28750813
All muscarinic acetylcholine receptors (M1-M5) are expressed in murine brain microvascular endothelium. PMID:28698560
Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method. PMID:28684785
GPCR-SSFE 2.0-a fragment-based molecular modeling web tool for Class A G-protein coupled receptors. PMID:28582569
Selectivity determinants of GPCR-G-protein binding. PMID:28489817
Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work. PMID:28484426
Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol. PMID:28473721
Computational design of ligand-binding membrane receptors with high selectivity. PMID:28459439
The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site. PMID:28442765
Pyrano[2,3,4-cd]indole as a Scaffold for Selective Nonbasic 5-HT6R Ligands. PMID:28435524
Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation. PMID:28325822
Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor. PMID:28323850
The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion. PMID:28267793
Bioinformatic prediction of G protein-coupled receptor encoding sequences from the transcriptome of the foreleg, including the Haller's organ, of the cattle tick, Rhipicephalus australis. PMID:28231302
7×7 RMSD matrix: A new method for quantitative comparison of the transmembrane domain structures in the G-protein coupled receptors. PMID:28223044
Structural Analysis of Chemokine Receptor-Ligand Interactions. PMID:28165741
Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. PMID:28145450
3D-e-Chem-VM: Structural Cheminformatics Research Infrastructure in a Freely Available Virtual Machine. PMID:28125221
The 24th annual Nucleic Acids Research database issue: a look back and upcoming changes. PMID:28053160
Relative Binding Free Energy Calculations Applied to Protein Homology Models. PMID:28024402
Structural insight to mutation effects uncover a common allosteric site in class C GPCRs. PMID:28011766
Nanobodies to Study G Protein-Coupled Receptor Structure and Function. PMID:27959623
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. PMID:27916541
The SWISS-MODEL Repository-new features and functionality. PMID:27899672
Clinically Approved Ion Channel Inhibitors Close Gates for Hepatitis C Virus and Open Doors for Drug Repurposing in Infectious Viral Diseases. PMID:27807238
Crystal Structure of the Human Cannabinoid Receptor CB1. PMID:27768894
Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region. PMID:27525504
Integrating structural and mutagenesis data to elucidate GPCR ligand binding. PMID:27475047
GPCR-ModSim: A comprehensive web based solution for modeling G-protein coupled receptors. PMID:27166369
GPCRdb: the G protein-coupled receptor database - an introduction. PMID:27155948
Galaxy7TM: flexible GPCR-ligand docking by structure refinement. PMID:27131365
The 2016 database issue of Nucleic Acids Research and an updated molecular biology database collection. PMID:26740669
GPCRDB: an information system for G protein-coupled receptors PubMed citations: 87.

87 articles citing: GPCRDB: an information system for G protein-coupled receptors

G-Protein coupled receptors: structure and function in drug discovery. PMID:35517958
Substitution scoring matrices for proteins - An overview. PMID:32954566
The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling. PMID:32296774
Structural Modeling and in Silico Screening of Potential Small-Molecule Allosteric Agonists of a Glucagon-like Peptide 1 Receptor. PMID:31459371
Role of Extracellular Loops and Membrane Lipids for Ligand Recognition in the Neuronal Adenosine Receptor Type 2A: An Enhanced Sampling Simulation Study. PMID:30322034
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system. PMID:29263378
GPCRdb: the G protein-coupled receptor database - an introduction. PMID:27155948
Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation. PMID:27000851
Reassessing ecdysteroidogenic cells from the cell membrane receptors' perspective. PMID:26847502
GPCRdb: an information system for G protein-coupled receptors. PMID:26582914
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. PMID:26464438
Apelin attenuates the osteoblastic differentiation of aortic valve interstitial cells via the ERK and PI3-K/Akt pathways. PMID:26142632
GLASS: a comprehensive database for experimentally validated GPCR-ligand associations. PMID:25971743
Generic GPCR residue numbers - aligning topology maps while minding the gaps. PMID:25541108
A desirability function-based scoring scheme for selecting fragment-like class A aminergic GPCR ligands. PMID:25326869
Chaperoning G protein-coupled receptors: from cell biology to therapeutics. PMID:24661201
GPCRDB: an information system for G protein-coupled receptors. PMID:24304901
Genetics of taste receptors. PMID:23886383
Gonadotropin-inhibitory hormone action in the brain and pituitary. PMID:23233850
Improvement of the Prediction Power of the CoMFA and CoMSIA Models on Histamine H3 Antagonists by Different Variable Selection Methods. PMID:23008805
A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors. PMID:22748306
Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors. PMID:22694093
Apelin-13 protects the brain against ischemic reperfusion injury and cerebral edema in a transient model of focal cerebral ischemia. PMID:22638858
GPR18 in microglia: implications for the CNS and endocannabinoid system signalling. PMID:22563843
Drug design for ever, from hype to hope. PMID:22252446
ChEMBL: a large-scale bioactivity database for drug discovery. PMID:21948594
Integrating GPCR-specific information with full text articles. PMID:21910883
Large-scale RNAi screen of G protein-coupled receptors involved in larval growth, molting and metamorphosis in the red flour beetle. PMID:21806814
GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models. PMID:21605354
The roles of transmembrane domain helix-III during rhodopsin photoactivation. PMID:21364764
Research resource: Update and extension of a glycoprotein hormone receptors web application. PMID:21292827
An improved classification of G-protein-coupled receptors using sequence-derived features. PMID:20696050
Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors. PMID:20687879
The control of reproductive physiology and behavior by gonadotropin-inhibitory hormone. PMID:20607134
Classification of G-protein coupled receptors based on support vector machine with maximum relevance minimum redundancy and genetic algorithm. PMID:20550715
Understanding functional residues of the cannabinoid CB1. PMID:20370713
7TMRmine: a Web server for hierarchical mining of 7TMR proteins. PMID:19538753
Heterotrimeric g proteins: insights into the neurobiology of mood disorders. PMID:18615130
GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. PMID:18533035
Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework. PMID:18178645
Mutation screening and haplotype analysis of the rhodopsin gene locus in Japanese patients with retinitis pigmentosa. PMID:17653048
Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. PMID:17537266
Eleven new putative aminergic G-protein coupled receptors from Amphioxus (Branchiostoma floridae): identification, sequence analysis and phylogenetic relationship. PMID:17225134
BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. PMID:17145705
Mining the Arabidopsis thaliana genome for highly-divergent seven transmembrane receptors. PMID:17064408
Ancient genomic architecture for mammalian olfactory receptor clusters. PMID:17010214
PhyloFacts: an online structural phylogenomic encyclopedia for protein functional and structural classification. PMID:16973001
Genomic scale sub-family assignment of protein domains. PMID:16877569
Identifying G-protein coupled receptors using weighted Levenshtein distance and the nearest neighbor method. PMID:16689695
Prediction and classification of human G-protein coupled receptors based on support vector machines. PMID:16689693
Structure modeling of all identified G protein-coupled receptors in the human genome. PMID:16485037
LGICdb: a manually curated sequence database after the genomes. PMID:16381861
Cross genome phylogenetic analysis of human and Drosophila G protein-coupled receptors: application to functional annotation of orphan receptors. PMID:16091152
Genome wide survey of G protein-coupled receptors in Tetraodon nigroviridis. PMID:16022726
Entropy and oligomerization in GPCRs. PMID:16012184
GPCRsclass: a web tool for the classification of amine type of G-protein-coupled receptors. PMID:15980444
Comparison of class A and D G protein-coupled receptors: common features in structure and activation. PMID:15966721
Sequence variation in G-protein-coupled receptors: analysis of single nucleotide polymorphisms. PMID:15784611
Critical evaluation of the JDO API for the persistence and portability requirements of complex biological databases. PMID:15642112
G protein-coupled receptors: in silico drug discovery in 3D. PMID:15277683
The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. PMID:15155892
Pharmacophore and receptor models for neurokinin receptors. PMID:15072436
Benzimidazole derivatives. 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists. PMID:14703122
Constraints on the conformation of the cytoplasmic face of dark-adapted and light-excited rhodopsin inferred from antirhodopsin antibody imprints. PMID:14573859
G protein-coupled receptor genes in the FANTOM2 database. PMID:12819145
Expression profiling and bioinformatic analyses of a novel stress-regulated multispanning transmembrane protein family from cereals and Arabidopsis. PMID:12746512
The G protein-coupled receptor repertoires of human and mouse. PMID:12679517
In silico pattern-based analysis of the human cytomegalovirus genome. PMID:12634390
Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. PMID:12627940
NRMD: Nuclear Receptor Mutation Database. PMID:12520016
Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands. PMID:12429062
Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity. PMID:12237474
Two tyrosine residues in the first transmembrane helix of the human vasoactive intestinal peptide receptors play a role in supporting the active conformation. PMID:12145104
Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin. PMID:11989623
Classification of G-protein coupled receptors by alignment-independent extraction of principal chemical properties of primary amino acid sequences. PMID:11910023
tGRAP, the G-protein coupled receptors mutant database. PMID:11752337
Olfactory Receptor Database: a metadata-driven automated population from sources of gene and protein sequences. PMID:11752336
Evolutionary relationships among G protein-coupled receptors using a clustered database approach. PMID:11741263
Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides. PMID:11708915
GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer. PMID:11588177
Mutational analysis of the human vasoactive intestinal peptide receptor subtype VPAC(2): role of basic residues in the second transmembrane helix. PMID:11498510
Tyr199 in transmembrane domain 5 of the beta2-adrenergic receptor interacts directly with the pharmacophore of a unique fluorenone-based antagonist. PMID:11237852
Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems. PMID:11125133
Classification of transmembrane protein families in the Caenorhabditis elegans genome and identification of human orthologs. PMID:11076853
Arginine 197 of the cholecystokinin-A receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin. PMID:10595537
Identification of ligand effector binding sites in transmembrane regions of the human G protein-coupled C3a receptor. PMID:10595533
Olfactory receptor database: a sensory chemoreceptor resource. PMID:10592268
GPCRdb in 2021: integrating GPCR sequence, structure and function PubMed citations: 65.

65 articles citing: GPCRdb in 2021: integrating GPCR sequence, structure and function

Cancer-Associated Mutations of the Adenosine A2A Receptor Have Diverse Influences on Ligand Binding and Receptor Functions. PMID:35897852
Opportunities and Challenges for In Silico Drug Discovery at Delta Opioid Receptors. PMID:35890173
Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression. PMID:35851064
AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors. PMID:35778488
Prediction of GPCR activity using machine learning. PMID:35685352
Understanding the molecular mechanism of endothelin ETA receptor selecting isopeptides endothelin-1 and -3. PMID:35660104
Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals. PMID:35652727
PRECOGx: exploring GPCR signaling mechanisms with deep protein representations. PMID:35639758
Substituted Purines as High-Affinity Histamine H3 Receptor Ligands. PMID:35631399
Molecular Characterization and Expression Analysis of Putative Class C (Glutamate Family) G Protein-Coupled Receptors in Ascidian Styela clava. PMID:35625509
Creation of targeted compound libraries based on 3D shape recognition. PMID:35608807
Functional Rescue of Inactivating Mutations of the Human Neurokinin 3 Receptor Using Pharmacological Chaperones. PMID:35562976
The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites. PMID:35538063
Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response. PMID:35537452
The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study. PMID:35507251
The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor. PMID:35495622
Prediction and Identification of GPCRs Targeting for Drug Repurposing in Osteosarcoma. PMID:35463319
Research Status of the Orphan G Protein Coupled Receptor 158 and Future Perspectives. PMID:35456013
MD Simulations Revealing Special Activation Mechanism of Cannabinoid Receptor 1. PMID:35425811
FAIR Genomes metadata schema promoting Next Generation Sequencing data reuse in Dutch healthcare and research. PMID:35418585
Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure. PMID:35365643
Post-Translational Modifications of G Protein-Coupled Receptors Revealed by Proteomics and Structural Biology. PMID:35355784
The Impact of the Secondary Binding Pocket on the Pharmacology of Class A GPCRs. PMID:35355719
In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates. PMID:35335981
Common coupling map advances GPCR-G protein selectivity. PMID:35302494
pH and proton-sensitive receptors in brain ischemia. PMID:35301897
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. PMID:35292680
Fentanyl Structure as a Scaffold for Opioid/Non-Opioid Multitarget Analgesics. PMID:35269909
The oxytocin signaling complex reveals a molecular switch for cation dependence. PMID:35241813
Two entry tunnels in mouse TAAR9 suggest the possibility of multi-entry tunnels in olfactory receptors. PMID:35177711
Knock-In Mouse Models to Investigate the Functions of Opioid Receptors in vivo. PMID:35173584
Community guidelines for GPCR ligand bias: IUPHAR review 32. PMID:35106752
The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation. PMID:35095763
Novel Molecular Targets of Antidepressants. PMID:35056845
Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery. PMID:35056070
Bifunctional Opioid/Melanocortin Peptidomimetics for Use in Neuropathic Pain: Variation in the Type and Length of the Linker Connecting the Two Pharmacophores. PMID:35054860
Mapping the Binding Sites of UDP and Prostaglandin E2 Glyceryl Ester in the Nucleotide Receptor P2Y6. PMID:35034430
In Vitro and In Silico Characterization of Kurarinone as a Dopamine D1A Receptor Antagonist and D2L and D4 Receptor Agonist. PMID:34926894
pdCSM-GPCR: predicting potent GPCR ligands with graph-based signatures. PMID:34901870
Structures of the σ2 receptor enable docking for bioactive ligand discovery. PMID:34880501
Applications of Cryo-EM in small molecule and biologics drug design. PMID:34812853
Molecular and in vivo phenotyping of missense variants of the human glucagon receptor. PMID:34801547
Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor. PMID:34780174
Towards the Idea of Molecular Brains. PMID:34769300
GPCR activation mechanisms across classes and macro/microscales. PMID:34759375
Purinergic GPCR transmembrane residues involved in ligand recognition and dimerization. PMID:34752329
Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations. PMID:34576210
The G protein database, GproteinDb. PMID:34570219
ProLIF: a library to encode molecular interactions as fingerprints. PMID:34563256
Common calcium-sensing receptor (CASR) gene variants do not modify risk for chronic pancreatitis in a Hungarian cohort. PMID:34481716
Biomolecule and Bioentity Interaction Databases in Systems Biology: A Comprehensive Review. PMID:34439912
Variation in the Evolution and Sequences of Proglucagon and the Receptors for Proglucagon-Derived Peptides in Mammals. PMID:34322093
Accurate prediction of protein structures and interactions using a three-track neural network. PMID:34282049
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. PMID:34262173
Ligands of Adrenergic Receptors: A Structural Point of View. PMID:34202543
Exploiting Knowledge on Structure-Activity Relationships for Designing Peptidomimetics of Endogenous Peptides. PMID:34200402
Bitter Taste and Olfactory Receptors: Beyond Chemical Sensing in the Tongue and the Nose. PMID:34173018
GPCRsignal: webserver for analysis of the interface between G-protein-coupled receptors and their effector proteins by dynamics and mutations. PMID:34060630
Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol-A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling. PMID:33922473
PyPLIF HIPPOS-Assisted Prediction of Molecular Determinants of Ligand Binding to Receptors. PMID:33922338
Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E4106.30×30K Variant in the Histamine H1 Receptor. PMID:33918180
Lowered sensitivity of bitter taste receptors to β-glucosides in bamboo lemurs: an instance of parallel and adaptive functional decline in TAS2R16? PMID:33849315
Structural insights into the lipid and ligand regulation of serotonin receptors. PMID:33762731
MSA-Regularized Protein Sequence Transformer toward Predicting Genome-Wide Chemical-Protein Interactions: Application to GPCRome Deorphanization. PMID:33757283
Current Trends in GPCR Allostery. PMID:33471142