INTEDE

The Interactome of Drug-Metabolizing Enzymes (INTEDE) is a database designed to systematically provide the data of all types of drug-metabolizing enzyme (DME) interaction. INTEDE confirmed 1,047 unique DMEs (448 host and 599 microbial), for the first time, using their metabolizing drugs. What’s more, for these newly confirmed DMEs, all types of their interactions (3,359 microbiome-DME interaction between 225 microbial species and 185 DMEs; 47,778 xenobiotics-DME interaction between 4,150 xenobiotics and 501 DMEs; 7,849 host protein-DME interaction between 565 human proteins and 566 DMEs) were comprehensively collected and then provided, which enabled the crosstalk analysis among multiple types. Because of the huge amount of accumulated data, the INTEDE made it possible to generalize key features for revealing disease etiology and optimizing clinical treatment.

Webpage:
https://idrblab.org/intede/

Publications:

Tags:

molecular biology drug

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