BacMet

Antibiotic resistance has become a major human health concern due to widespread use, misuse and overuse of antibiotics. In addition to antibiotics, antibacterial biocides and metals can contribute to the development and maintenance of antibiotic resistance in bacterial communities through co-selection (1-2). We have developed BacMet – a manually curated database of antibacterial biocide- and metal-resistance genes based on an in-depth review of the scientific literature. The database will facilitate the research to understand co- and cross-resistance of biocide and metals to antibiotics within bacterial genomes, as well as in complex microbial communities (metagenomes) from different environments and understand the development of tolerance mechanisms of bacteria towards commercial biocidal and metal-based products. As of 30 October 2013, the BacMet database contains 470 experimentally verified resistance genes. In addition, the database also contains 25,477 potential resistance genes collected from public sequence repositories (3-5) and identified by their sequence similarity to genes with verified resistance function. All resistance genes in the BacMet database have been organized according to their molecular function and induced resistance phenotype. The database is freely available at http://bacmet.biomedicine.gu.se.

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http://bacmet.biomedicine.gu.se/

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molecular biology drug

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