R3KS7N last accessed: 2022-11-04

metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929

CTD - Comparative Toxicogenomics Database
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

The Comparative Toxicogenomics Database (CTD)
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:15.263858

ctd
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:15.263858

Other names: CTD, CTD - Comparative Toxicogenomics Database, The Comparative Toxicogenomics Database (CTD), ctd

Database that aims to advance understanding about how environmental exposures affect human health. It provides manually curated information about chemical–gene/protein interactions, chemical–disease and gene–disease relationships. These data are integrated with functional and pathway data to aid in development of hypotheses about the mechanisms underlying environmentally influenced diseases.

Webpage:

http://ctdbase.org

Licence:

Name: CTD - specific. Requires permission for commercial purposes.
URL: https://ctdbase.org/about/legal.jsp

Publications: (25)

Publications
More detailed information about this field from each metasource.

The Comparative Toxicogenomics Database: update 2019
PMID: 30247620
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929

metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

The Comparative Toxicogenomics Database: update 2017
PMID: 27651457
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929

metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

The Comparative Toxicogenomics Database's 10th year anniversary: update 2015
PMID: 25326323
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929

metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

The Comparative Toxicogenomics Database: update 2013
PMID: 23093600
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929

metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

Comparative Toxicogenomics Database (CTD): update 2021
PMID: 33068428
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:15.263858

The Comparative Toxicogenomics Database: update 2011
PMID: 20864448
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929

metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:15.263858

Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks
PMID: 18782832
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929

MEDIC: a practical disease vocabulary used at the Comparative Toxicogenomics Database
PMID: 22434833
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

The Comparative Toxicogenomics Database (CTD)
PMID: 12760826
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929

The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies
PMID: 16902965
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929

A CTD-Pfizer collaboration: manual curation of 88,000 scientific articles text mined for drug-disease and drug-phenotype interactions
PMID: 24288140
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

The comparative toxicogenomics database: a cross-species resource for building chemical-gene interaction networks
PMID: 16675512
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929

The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study
PMID: 18845002
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

Text mining effectively scores and ranks the literature for improving chemical-gene-disease curation at the comparative toxicogenomics database
PMID: 23613709
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

The curation paradigm and application tool used for manual curation of the scientific literature at the Comparative Toxicogenomics Database
PMID: 21933848
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

Accessing an Expanded Exposure Science Module at the Comparative Toxicogenomics Database
PMID: 29351546
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database
PMID: 27170236
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways
PMID: 29846728
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database
PMID: 27171405
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

GeneComps and ChemComps: a new CTD metric to identify genes and chemicals with shared toxicogenomic profiles
PMID: 20198196
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

Leveraging the Comparative Toxicogenomics Database to Fill in Knowledge Gaps for Environmental Health: A Test Case for Air Pollution-induced Cardiovascular Disease
PMID: 32663284
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

Targeted journal curation as a method to improve data currency at the Comparative Toxicogenomics Database
PMID: 23221299
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

DiseaseComps: a metric that discovers similar diseases based upon common toxicogenomic profiles at CTD
PMID: 22125387
metasource: Fairsharing.org
version: FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: June 22, 2021, 11:56 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using the Comparative Toxicogenomics Database
PMID: 34458863
metasource: bio.tools
version: extracted_at: 2022-11-04T11:25:15.263858

http://dx.doi.org/10.1093/nar/gkaa891
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

The Comparative Toxicogenomics Database: update 2019 PubMed citations: 313.

313 articles citing: The Comparative Toxicogenomics Database: update 2019

SApredictor: An Expert System for Screening Chemicals Against Structural Alerts. PMID:35910729
A Narrative Literature Review of Natural Language Processing Applied to the Occupational Exposome. PMID:35886395
An Integrative Heterogeneous Graph Neural Network-Based Method for Multi-Labeled Drug Repurposing. PMID:35873597
Comprehensive Assessment of Indian Variations in the Druggable Kinome Landscape Highlights Distinct Insights at the Sequence, Structure and Pharmacogenomic Stratum. PMID:35865963
Exploration of dilated cardiomyopathy for biomarkers and immune microenvironment: evidence from RNA-seq. PMID:35850644
Most Pathways Can Be Related to the Pathogenesis of Alzheimer's Disease. PMID:35813951
In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2. PMID:35809412
iPCD: A Comprehensive Data Resource of Regulatory Proteins in Programmed Cell Death. PMID:35805101
Comparison of Descriptor- and Fingerprint Sets in Machine Learning Models for ADME-Tox Targets. PMID:35755260
An Integrated Mass Spectrometry-Based Glycomics-Driven Glycoproteomics Analytical Platform to Functionally Characterize Glycosylation Inhibitors. PMID:35744954
Identifying Candidate Flavonoids for Non-Alcoholic Fatty Liver Disease by Network-Based Strategy. PMID:35721123
A harmonized chemical monitoring database for support of exposure assessments. PMID:35710792
Multi-view heterogeneous molecular network representation learning for protein-protein interaction prediction. PMID:35710342
Network approaches for modeling the effect of drugs and diseases. PMID:35704883
Integrative analysis to explore the biological association between environmental skin diseases and ambient particulate matter. PMID:35697899
Altered Cellular Immunity and Differentially Expressed Immune-Related Genes in Patients With Systemic Sclerosis-Associated Pulmonary Arterial Hypertension. PMID:35663995
AnthraxKP: a knowledge graph-based, Anthrax Knowledge Portal mined from biomedical literature. PMID:35653350
Evaluation of Biomarkers and Immune Microenvironment of Osteoarthritis: Evidence From Omics Data and Machine Learning. PMID:35651940
Comprehensive analysis of the expression, prognostic significance, and function of FAM83 family members in breast cancer. PMID:35650627
Consensus Gene Co-Expression Network Analysis Identifies Novel Genes Associated with Severity of Fibrotic Lung Disease. PMID:35628257
Exploration of the System-Level Mechanisms of the Herbal Drug FDY003 for Pancreatic Cancer Treatment: A Network Pharmacological Investigation. PMID:35591866
A network-biology led computational drug repurposing strategy to prioritize therapeutic options for COVID-19. PMID:35578630
Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility Differences in a Genetically Diverse Zebrafish Model. PMID:35573279
Design and application of a knowledge network for automatic prioritization of drug mechanisms. PMID:35561182
Hierarchical network analysis of co-occurring bioentities in literature. PMID:35550589
Andrographolide in atherosclerosis: integrating network pharmacology and in vitro pharmacological evaluation. PMID:35543243
Utilizing Network Pharmacology and Molecular Docking Integrated Surface Plasmon Resonance Technology to Investigate the Potential Targets and Mechanisms of Tripterygium wilfordii against Pulmonary Artery Hypertension. PMID:35535154
Network Pharmacology and Comparative Transcriptome Reveals Biotargets and Mechanisms of Curcumol Treating Lung Adenocarcinoma Patients With COVID-19. PMID:35520289
Systematic Elaboration of the Pharmacological Targets and Potential Mechanisms of ZhiKe GanCao Decoction for Preventing and Delaying Intervertebral Disc Degeneration. PMID:35497916
Unraveling the molecular mechanism of l-menthol against cervical cancer based on network pharmacology, molecular docking and in vitro analysis. PMID:35467269
FAM201A, a long noncoding RNA potentially associated with atrial fibrillation identified by ceRNA network analyses and WGCNA. PMID:35410298
Integration of Neighbor Topologies Based on Meta-Paths and Node Attributes for Predicting Drug-Related Diseases. PMID:35409235
Identification of host transcriptome-guided repurposable drugs for SARS-CoV-1 infections and their validation with SARS-CoV-2 infections by using the integrated bioinformatics approaches. PMID:35390032
MOET: a web-based gene set enrichment tool at the Rat Genome Database for multiontology and multispecies analyses. PMID:35380657
INPUT: An intelligent network pharmacology platform unique for traditional Chinese medicine. PMID:35356545
Computational methods, databases and tools for synthetic lethality prediction. PMID:35352098
Integrative analyses of biomarkers and pathways for heart failure. PMID:35346191
FibROAD: a manually curated resource for multi-omics level evidence integration of fibrosis research. PMID:35277958
Biological mechanisms of aging predict age-related disease co-occurrence in patients. PMID:35259281
Exploration of Potential Integrated Models of N6-Methyladenosine Immunity in Systemic Lupus Erythematosus by Bioinformatic Analyses. PMID:35197962
Network Pharmacology Integrated Molecular Docking Revealed the Mechanism of Jianpi Yiqi Taohua Decoction Against Ulcerative Colitis. PMID:35173140
Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1). PMID:35166167
Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression. PMID:35145232
EDTox: an R Shiny application to predict the endocrine disruption potential of compounds. PMID:35134136
CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle. PMID:35123514
Non-SMC condensin I complex subunit H (NCAPH), a regulator of cell cycle, predicts poor prognosis in lung adenocarcinoma patients: a study mainly based on TCGA and GEO database. PMID:35117357
A Data Mining Approach Reveals Chemicals Detected at Higher Levels in Non-Hispanic Black Women Target Preterm Birth Genes and Pathways. PMID:35107823
DDA-SKF: Predicting Drug-Disease Associations Using Similarity Kernel Fusion. PMID:35095495
Knowledge-Driven Approaches to Create the MTox700+ Metabolite Panel for Predicting Toxicity. PMID:35094093
Epigenetic landscape of drug responses revealed through large-scale ChIP-seq data analyses. PMID:35073843
The speed of information propagation in the scientific network distorts biomedical research. PMID:35070506
The System Research of the Molecular Mechanism of Quyushengxin Capsule in the Treatment of Osteonecrosis of the Femoral Head. PMID:35069756
Metadichol®: A Novel Nanolipid Formulation That Inhibits SARS-CoV-2 and a Multitude of Pathological Viruses In Vitro. PMID:35039793
Deep Learning-Assisted Repurposing of Plant Compounds for Treating Vascular Calcification: An In Silico Study with Experimental Validation. PMID:35035662
Diacerein, an inhibitor of IL-1β downstream mediated apoptosis, improves radioimmunotherapy in a mouse model of Burkitt's lymphoma. PMID:35018248
Protein interaction networks define the genetic architecture of preterm birth. PMID:35013336
Transcriptomic and Metabolomic Profiling in Helicobacter pylori-Induced Gastric Cancer Identified Prognosis- and Immunotherapy-Relevant Gene Signatures. PMID:35004676
Biomedical relation extraction via knowledge-enhanced reading comprehension. PMID:34991458
Screening and analysis of RNAs associated with activated memory CD4 and CD8 T cells in liver cancer. PMID:34980144
Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury. PMID:34975499
Exploring complex and heterogeneous correlations on hypergraph for the prediction of drug-target interactions. PMID:34950907
Potential Mechanisms of Triptolide against Diabetic Cardiomyopathy Based on Network Pharmacology Analysis and Molecular Docking. PMID:34926700
EMS1/DLL4-Notch Signaling Axis Augments Cell Cycle-Mediated Tumorigenesis and Progress in Human Adrenocortical Carcinoma. PMID:34858850
BioNet: a large-scale and heterogeneous biological network model for interaction prediction with graph convolution. PMID:34849567
The Aliment to Bodily Condition knowledgebase (ABCkb): a database connecting plants and human health. PMID:34838100
Chemical Exposures Affect Innate Immune Response to SARS-CoV-2. PMID:34830356
WGCNA Identification of Genes and Pathways Involved in the Pathogenesis of Postmenopausal Osteoporosis. PMID:34815706
Pharmacological Mechanism of Danggui-Sini Formula for Intervertebral Disc Degeneration: A Network Pharmacology Study. PMID:34805401
Linking Diabetes Mellitus with Alzheimer's Disease: Bioinformatics Analysis for the Potential Pathways and Characteristic Genes. PMID:34779951
Functional drug-target-disease network analysis of gene-phenotype connectivity for curcumin in hepatocellular carcinoma. PMID:34754622
CCR5 is a prognostic biomarker and an immune regulator for triple negative breast cancer. PMID:34717291
The Eco-Exposome Concept: Supporting an Integrated Assessment of Mixtures of Environmental Chemicals. PMID:34714945
Cancer CRC: A Comprehensive Cancer Core Transcriptional Regulatory Circuit Resource and Analysis Platform. PMID:34712617
Drug repurposing improves disease targeting 11-fold and can be augmented by network module targeting, applied to COVID-19. PMID:34667255
Effects of Bacille Calmette Guerin (BCG) vaccination during COVID-19 infection. PMID:34624759
Targeting cathepsins: A potential link between COVID-19 and associated neurological manifestations. PMID:34604555
Humans and machines in biomedical knowledge curation: hypertrophic cardiomyopathy molecular mechanisms' representation. PMID:34600580
Effect of ondansetron on reducing ICU mortality in patients with acute kidney injury. PMID:34593872
Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation. PMID:34580601
Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoids. PMID:34548904
DNA methylation and gene expression profiles to identify childhood atopic asthma associated genes. PMID:34525985
Epigenome-Wide DNA Methylation and Pesticide Use in the Agricultural Lung Health Study. PMID:34516295
Identification of HIF-1α/VEGFA signaling pathway and transcription factors in Kashin-Beck disease by integrated bioinformatics analysis. PMID:34504569
Catalyzing Knowledge-Driven Discovery in Environmental Health Sciences through a Community-Driven Harmonized Language. PMID:34501574
Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis. PMID:34480296
Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using the Comparative Toxicogenomics Database. PMID:34458863
The Identification of Childhood Asthma Progression-Related lncRNAs and mRNAs Suitable as Biomarkers Using Weighted Gene Coexpression Network Analysis. PMID:34456632
Identification of COVID-19 and Dengue Host Factor Interaction Networks Based on Integrative Bioinformatics Analyses. PMID:34394108
Data mining in clinical big data: the frequently used databases, steps, and methodological models. PMID:34380547
Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach. PMID:34367254
Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats. PMID:34321866
A Biomedical Knowledge Graph System to Propose Mechanistic Hypotheses for Real-World Environmental Health Observations: Cohort Study and Informatics Application. PMID:34283031
Network Pharmacology-Based Dissection of the Active Ingredients and Protective Mechanism of the Salvia Miltiorrhiza and Panax Notoginseng Herb Pair against Insulin Resistance. PMID:34278114
Sevoflurane pretreatment regulates abnormal expression of MicroRNAs associated with spinal cord ischemia/reperfusion injury in rats. PMID:34268365
Study on the Molecular Mechanism of the Herbal Couple Sparganii Rhizoma-Curcumae Rhizoma in the Treatment of Lung Cancer Based on Network Pharmacology. PMID:34239587
A circular RNAs dataset landscape reveals potential signatures for the detection and prognosis of early-stage lung adenocarcinoma. PMID:34229638
Medical Concept Normalization in Clinical Trials with Drug and Disease Representation Learning. PMID:34213526
Comprehensive analysis of DNA methylation and gene expression profiles in gestational diabetes mellitus. PMID:34190178
Bioinformatics analysis of key biomarkers for retinoblastoma. PMID:34187205
Analysis of Nuclear Encoded Mitochondrial Gene Networks in Cervical Cancer. PMID:34181336
Prediction and Verification of the Major Ingredients and Molecular Targets of Tripterygii Radix Against Rheumatoid Arthritis. PMID:34168557
Node Similarity Based Graph Convolution for Link Prediction in Biological Networks. PMID:34152393
A Novel Metric to Quantify the Effect of Pathway Enrichment Evaluation With Respect to Biomedical Text-Mined Terms: Development and Feasibility Study. PMID:34142969
A structural deep network embedding model for predicting associations between miRNA and disease based on molecular association network. PMID:34135401
The association between hypertension and nonalcoholic fatty liver disease (NAFLD): literature evidence and systems biology analysis. PMID:34096467
Pharmacological Mechanisms Underlying the Therapeutic Effects of Danhong Injection on Cerebral Ischemia. PMID:34093718
Differentially Expressed Genes and Enriched Signaling Pathways in the Adipose Tissue of Obese People. PMID:34093637
Investigation of the Multi-Target Mechanism of Guanxin-Shutong Capsule in Cerebrovascular Diseases: A Systems Pharmacology and Experimental Assessment. PMID:34054530
An Integrated Analysis of Network Pharmacology, Molecular Docking, and Experiment Validation to Explore the New Candidate Active Component and Mechanism of Cuscutae Semen-Mori Fructus Coupled-Herbs in Treating Oligoasthenozoospermia. PMID:34040346
Based on Network Pharmacology and Molecular Docking to Explore the Underlying Mechanism of Huangqi Gegen Decoction for Treating Diabetic Nephropathy. PMID:34035828
Differentially expressed genes, lncRNAs, and competing endogenous RNAs in Kawasaki disease. PMID:34026343
Signature RNAS and related regulatory roles in type 1 diabetes mellitus based on competing endogenous RNA regulatory network analysis. PMID:34006268
Network Pharmacology-Based Investigation of the Therapeutic Mechanisms of Action of Danning Tablets in Nonalcoholic Fatty Liver Disease. PMID:33995543
Bioinformatics and system biology approaches to identify the diseasome and comorbidities complexities of SARS-CoV-2 infection with the digestive tract disorders. PMID:33993223
The differences in SARS-CoV and SARS-CoV-2 specific co-expression network mediated biological process in human gut enterocytes. PMID:33957338
Network Pharmacology and Molecular Docking Suggest the Mechanism for Biological Activity of Rosmarinic Acid. PMID:33936238
In Silico Exploration of the Potential Role of Acetaminophen and Pesticides in the Etiology of Autism Spectrum Disorder. PMID:33925648
Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions. PMID:33917455
MultiVERSE: a multiplex and multiplex-heterogeneous network embedding approach. PMID:33888761
Network Pharmacology Analysis of ZiShenWan for Diabetic Nephropathy and Experimental Verification of Its Anti-Inflammatory Mechanism. PMID:33883881
Gene fusion of IL7 involved in the regulation of idiopathic pulmonary fibrosis. PMID:33878985
SeBioGraph: Semi-supervised Deep Learning for the Graph via Sustainable Knowledge Transfer. PMID:33867966
Biomarkers mining for spinal cord injury based on integrated multi-transcriptome expression profile data. PMID:33863336
DNA methylation in the adipose tissue and whole blood of Agent Orange-exposed Operation Ranch Hand veterans: a pilot study. PMID:33849548
iDEP Web Application for RNA-Seq Data Analysis. PMID:33835455
Investigating Molecular Mechanisms of Immunotoxicity and the Utility of ToxCast for Immunotoxicity Screening of Chemicals Added to Food. PMID:33804855
Integrative Data Analytic Framework to Enhance Cancer Precision Medicine. PMID:33796878
An Integrative in silico Drug Repurposing Approach for Identification of Potential Inhibitors of SARS-CoV-2 Main Protease. PMID:33787066
De novo mutations in folate-related genes associated with common developmental disorders. PMID:33777337
Identification and Analysis of Potential Key Genes Associated With Hepatocellular Carcinoma Based on Integrated Bioinformatics Methods. PMID:33767726
Potential Association Between Asthma, Helicobacter pylori Infection, and Gastric Cancer. PMID:33763365
A small molecule compound berberine as an orally active therapeutic candidate against COVID-19 and SARS: A computational and mechanistic study. PMID:33749932
Network Pharmacology-Based Study on the Molecular Biological Mechanism of Action for Qingdu Decoction against Chronic Liver Injury. PMID:33747110
Deciphering the Pharmacological Mechanisms of Guizhi-Fuling Capsule on Primary Dysmenorrhea Through Network Pharmacology. PMID:33746752
Elucidation of the Mechanism of Action of Ginseng Against Acute Lung Injury/Acute Respiratory Distress Syndrome by a Network Pharmacology-Based Strategy. PMID:33746744
Identification of disease treatment mechanisms through the multiscale interactome. PMID:33741907
PRYNT: a tool for prioritization of disease candidates from proteomics data using a combination of shortest-path and random walk algorithms. PMID:33707596
Computational Analysis Indicates That PARP1 Acts as a Histone Deacetylases Interactor Sharing Common Lysine Residues for Acetylation, Ubiquitination, and SUMOylation in Alzheimer's and Parkinson's Disease. PMID:33681613
Decoding the Mechanism of Huanglian Jiedu Decoction in Treating Pneumonia Based on Network Pharmacology and Molecular Docking. PMID:33681222
Analysis of MicroRNAs Associated With Carotid Atherosclerotic Plaque Rupture With Thrombosis. PMID:33679879
Drug-Target Interaction Prediction Based on Adversarial Bayesian Personalized Ranking. PMID:33628808
Uncovering the Anti-Lung-Cancer Mechanisms of the Herbal Drug FDY2004 by Network Pharmacology. PMID:33628308
A Network Pharmacology Study on the Molecular Mechanisms of FDY003 for Breast Cancer Treatment. PMID:33628298
Public data sources to support systems toxicology applications. PMID:33604492
System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of GanDouLing for Wilson's Disease. PMID:33564316
Construction and Analysis of a ceRNA Network in Cardiac Fibroblast During Fibrosis Based on in vivo and in vitro Data. PMID:33552116
Meta-analysis of transcriptome datasets: An alternative method to study IL-6 regulation in coronavirus disease 2019. PMID:33520118
Network pharmacology integrated molecular docking reveals the bioactive components and potential targets of Morinda officinalis-Lycium barbarum coupled-herbs against oligoasthenozoospermia. PMID:33500463
The landscape of nutri-informatics: a review of current resources and challenges for integrative nutrition research. PMID:33494105
Machine learning applications in drug development. PMID:33489002
Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions. PMID:33469342
Bioinformatics and system biology approach to identify the influences of COVID-19 on cardiovascular and hypertensive comorbidities. PMID:33458761
Pharmacological Network Reveals the Active Mechanism of Qi-Replenishing, Spleen-Strengthening, Phlegm-Dispelling, and Blood-Nourishing Fufang on Coronary Heart Disease. PMID:33456482
Artificial Intelligence in Drug Discovery: A Comprehensive Review of Data-driven and Machine Learning Approaches. PMID:33437151
An ensemble learning approach for modeling the systems biology of drug-induced injury. PMID:33435983
Ethanol exposure drives colon location specific cell composition changes in a normal colon crypt 3D organoid model. PMID:33432071
Linking chemical and disease entities to ontologies by integrating PageRank with extracted relations from literature. PMID:33430995
DF-MDA: An effective diffusion-based computational model for predicting miRNA-disease association. PMID:33429082
Prediction of lncRNA-disease associations via an embedding learning HOPE in heterogeneous information networks. PMID:33425486
Brain Disease Network Analysis to Elucidate the Neurological Manifestations of COVID-19. PMID:33409839
Identification of Pro-Fibrotic Macrophage Populations by Single-Cell Transcriptomic Analysis in West Highland White Terriers Affected With Canine Idiopathic Pulmonary Fibrosis. PMID:33384697
Identification of miRNAs as the Crosstalk in the Interaction between Neural Stem/Progenitor Cells and Endothelial Cells. PMID:33381243
A Systematic Review and Meta-Analysis Considering the Risk for Congenital Heart Defects of Antidepressant Classes and Individual Antidepressants. PMID:33354752
An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak-Gamcho Decoction: A Network Pharmacology Study. PMID:33343676
Identification and Characterization of Biomarkers and Their Role in Opioid Addiction by Integrated Bioinformatics Analysis. PMID:33328875
Identification of SCARA3 with potential roles in metabolic disorders. PMID:33318306
Mechanism of Action of Bu-Fei-Yi-Shen Formula in Treating Chronic Obstructive Pulmonary Disease Based on Network Pharmacology Analysis and Molecular Docking Validation. PMID:33313323
Circular RNA hsa_circ_0005114-miR-142-3p/miR-590-5p-adenomatous polyposis coli protein axis as a potential target for treatment of glioma. PMID:33281969
Role of COL3A1 and POSTN on Pathologic Stages of Esophageal Cancer. PMID:33280513
Screening of T Cell-Related Long Noncoding RNA-MicroRNA-mRNA Regulatory Networks in Non-Small-Cell Lung Cancer. PMID:33274216
CGINet: graph convolutional network-based model for identifying chemical-gene interaction in an integrated multi-relational graph. PMID:33243142
HLH-11 modulates lipid metabolism in response to nutrient availability. PMID:33235199
A developmental stage-specific network approach for studying dynamic co-regulation of transcription factors and microRNAs during craniofacial development. PMID:33234712
Genomics of hypertension: the road to precision medicine. PMID:33219353
Moving targets in drug discovery. PMID:33214619
Integrating Pharmacology and Gut Microbiota Analysis to Explore the Mechanism of Citri Reticulatae Pericarpium Against Reserpine-Induced Spleen Deficiency in Rats. PMID:33192528
Virtual screening and network pharmacology-based synergistic mechanism identification of multiple components contained in Guanxin V against coronary artery disease. PMID:33187508
Identification of potential target genes and crucial pathways in small cell lung cancer based on bioinformatic strategy and human samples. PMID:33186389
Regulation of GABAA and 5-HT Receptors Involved in Anxiolytic Mechanisms of Jujube Seed: A System Biology Study Assisted by UPLC-Q-TOF/MS and RT-qPCR Method. PMID:33178009
A meta-analysis of BRF2 as a prognostic biomarker in invasive breast carcinoma. PMID:33176745
Identification of biomarkers and pathways in hypertensive nephropathy based on the ceRNA regulatory network. PMID:33176720
Identification of inflammation‑associated circulating long non‑coding RNAs and genes in intracranial aneurysm rupture‑induced subarachnoid hemorrhage. PMID:33174039
Pan-transcriptome-based candidate therapeutic discovery for idiopathic pulmonary fibrosis. PMID:33167785
Bioinformatics Gene Analysis of Potential Biomarkers and Therapeutic Targets for Unstable Atherosclerotic Plaque-Related Stroke. PMID:33155176
Exploration in the Mechanism of Kaempferol for the Treatment of Gastric Cancer Based on Network Pharmacology. PMID:33145355
SMARCD3 is a potential prognostic marker and therapeutic target in CAFs. PMID:33125346
High-depth African genomes inform human migration and health. PMID:33116287
Data on chemical-gene interactions and biological categories enriched with genes sensitive to chemical exposures. PMID:33102660
Network Pharmacology Identifies the Mechanisms of Sang-Xing-Zhi-Ke-Fang against Pharyngitis. PMID:33101439
Identification of Hub Genes and Potential Molecular Mechanisms in Patients with HBV-Associated Acute Liver Failure. PMID:33100826
VARAdb: a comprehensive variation annotation database for human. PMID:33095866
Utility of Extrapolating Human S1500+ Genes to the Whole Transcriptome: Tunicamycin Case Study. PMID:33088175
Systems Level Analysis and Identification of Pathways and Key Genes Associated with Delirium. PMID:33086708
Assessing the consequences of environmental exposures on the expression of the human receptor and proteases involved in SARS-CoV-2 cell-entry. PMID:33069705
Comparative Toxicogenomics Database (CTD): update 2021. PMID:33068428
Computational Approaches in Preclinical Studies on Drug Discovery and Development. PMID:33062633
Environmental Epigenetics of Diesel Particulate Matter Toxicogenomics. PMID:33050454
INTEDE: interactome of drug-metabolizing enzymes. PMID:33045737
In Silico Prediction of Molecular Targets of Astragaloside IV for Alleviation of COVID-19 Hyperinflammation by Systems Network Pharmacology and Bioinformatic Gene Expression Analysis. PMID:33041797
Bioinformatics Analysis of Genes and Mechanisms in Postherpetic Neuralgia. PMID:33029266
Single-Cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning. PMID:33021809
Computational Drug Repositioning Identifies Potentially Active Therapies for Chordoma. PMID:33017025
iMDA-BN: Identification of miRNA-disease associations based on the biological network and graph embedding algorithm. PMID:33005302
Exploring food contents in scientific literature with FoodMine. PMID:33004889
A multimodal deep learning-based drug repurposing approach for treatment of COVID-19. PMID:32997257
Herbal pair Huangqin-Baishao: mechanisms underlying inflammatory bowel disease by combined system pharmacology and cell experiment approach. PMID:32988394
Systematic Elucidation of the Mechanism of Quercetin against Gastric Cancer via Network Pharmacology Approach. PMID:32964029
Ecotoxico-lipidomics: An emerging concept to understand chemical-metabolic relationships in comparative fish models. PMID:32956922
Systems pharmacology-based approach to investigate the mechanisms of Danggui-Shaoyao-san prescription for treatment of Alzheimer's disease. PMID:32948180
Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approach. PMID:32920000
PCOSKBR2: a database of genes, diseases, pathways, and networks associated with polycystic ovary syndrome. PMID:32895427
Prediction of drug-target interactions from multi-molecular network based on LINE network representation method. PMID:32894154
Systems-level differential gene expression analysis reveals new genetic variants of oral cancer. PMID:32887903
Ontological approach to the knowledge systematization of a toxic process and toxic course representation framework for early drug risk management. PMID:32883995
Computational Methods and Software Tools for Functional Analysis of miRNA Data. PMID:32872205
Genomic landscape of the immune microenvironments of brain metastases in breast cancer. PMID:32867782
Screening and Identification of Potential Peripheral Blood Biomarkers for Alzheimer's Disease Based on Bioinformatics Analysis. PMID:32812532
Enhancing and Complementary Mechanisms of Synergistic Action of Acori Tatarinowii Rhizoma and Codonopsis Radix for Alzheimer's Disease Based on Systems Pharmacology. PMID:32802132
Larval zebrafish as an in vitro model for evaluating toxicological effects of mycotoxins. PMID:32800244
Pathogenetic profiling of COVID-19 and SARS-like viruses. PMID:32778874
Levels of endocrine-disrupting chemicals are associated with changes in the peri-pubertal epigenome. PMID:32755991
Phexpo: a package for bidirectional enrichment analysis of phenotypes and chemicals. PMID:32734156
MIPDH: A Novel Computational Model for Predicting microRNA-mRNA Interactions by DeepWalk on a Heterogeneous Network. PMID:32715187
Integrated Analysis of Three Publicly Available Gene Expression Profiles Identified Genes and Pathways Associated with Clear Cell Renal Cell Carcinoma. PMID:32712616
Identification of potential molecular mechanisms and small molecule drugs in myocardial ischemia/reperfusion injury. PMID:32696819
Identification of potential crucial genes in atrial fibrillation: a bioinformatic analysis. PMID:32682418
Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling. PMID:32663517
Leveraging the Comparative Toxicogenomics Database to Fill in Knowledge Gaps for Environmental Health: A Test Case for Air Pollution-induced Cardiovascular Disease. PMID:32663284
Network-principled deep generative models for designing drug combinations as graph sets. PMID:32657357
Underlying Mechanism of Insulin Resistance: A Bioinformatics Analysis Based on Validated Related-Genes from Public Disease Databases. PMID:32651353
Molecular Mapping of Hydrogen Sulfide Targets in Normal Human Keratinocytes. PMID:32629886
Dioxin-like compound exposures and DNA methylation in the Anniston Community Health Survey Phase II. PMID:32629249
A Network Pharmacology Approach to Explore the Mechanisms of Shugan Jianpi Formula in Liver Fibrosis. PMID:32617108
Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective. PMID:32599245
Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells. PMID:32595654
Prediction of Drug-Target Interactions From Multi-Molecular Network Based on Deep Walk Embedding Model. PMID:32582646
A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy. PMID:32581127
Learning Representations to Predict Intermolecular Interactions on Large-Scale Heterogeneous Molecular Association Network. PMID:32580123
Dr AFC: drug repositioning through anti-fibrosis characteristic. PMID:32572450
Immune-related genes in tumor-specific CD4+ and CD8+ T cells in colon cancer. PMID:32571262
Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target. PMID:32560530
Identification of Time-Invariant Biomarkers for Non-Genotoxic Hepatocarcinogen Assessment. PMID:32560183
Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma. PMID:32546976
Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone. PMID:32546528
Bioentity2vec: Attribute- and behavior-driven representation for predicting multi-type relationships between bioentities. PMID:32533701
Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs. PMID:32521033
Scoring functions for drug-effect similarity. PMID:32484516
Predicting The Effects of Chemical-Protein Interactions On Proteins Using Tensor Factorisation. PMID:32477664
Resveratrol: Multi-Targets Mechanism on Neurodegenerative Diseases Based on Network Pharmacology. PMID:32477148
Establishment of a CALU, AURKA, and MCM2 gene panel for discrimination of metastasis from primary colon and lung cancers. PMID:32469983
Bioinformatics Analysis and Identification of Underlying Biomarkers Potentially Linking Allergic Rhinitis and Asthma. PMID:32460303
ThETA: transcriptome-driven efficacy estimates for gene-based TArget discovery. PMID:32437556
Genomics of Blood Pressure and Hypertension: Extending the Mosaic Theory Toward Stratification. PMID:32389342
Applying knowledge-driven mechanistic inference to toxicogenomics. PMID:32387679
Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing. PMID:32355577
Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis. PMID:32346024
A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis. PMID:32344708
BioConceptVec: Creating and evaluating literature-based biomedical concept embeddings on a large scale. PMID:32324731
Predicting miRNA-disease association from heterogeneous information network with GraRep embedding model. PMID:32313121
RA-map: building a state-of-the-art interactive knowledge base for rheumatoid arthritis. PMID:32311035
Identifying 5 Common Psychiatric Disorders Associated Chemicals Through Integrative Analysis of Genome-Wide Association Study and Chemical-Gene Interaction Datasets. PMID:32291453
Unveiling new disease, pathway, and gene associations via multi-scale neural network. PMID:32251458
Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer's Disease. PMID:32197305
Pharmacological target-focused transcriptomic analysis of native vs cultured human and mouse dorsal root ganglia. PMID:32197039
Prediction of Side Effects Using Comprehensive Similarity Measures. PMID:32190647
A learning based framework for diverse biomolecule relationship prediction in molecular association network. PMID:32170157
Development and validation of a lipogenic genes panel for diagnosis and recurrence of colorectal cancer. PMID:32155177
CancerLivER: a database of liver cancer gene expression resources and biomarkers. PMID:32147717
Identification of the Molecular Mechanisms of Peimine in the Treatment of Cough Using Computational Target Fishing. PMID:32131410
PHARMIP: An insilico method to predict genetics that underpin adverse drug reactions. PMID:32123669
Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease. PMID:32109936
Network Pharmacology-Based Investigation of the System-Level Molecular Mechanisms of the Hematopoietic Activity of Samul-Tang, a Traditional Korean Herbal Formula. PMID:32104198
Potential frameworks to support evaluation of mechanistic data for developmental neurotoxicity outcomes: A symposium report. PMID:32068112
Exploration of databases and methods supporting drug repurposing: a comprehensive survey. PMID:32055842
Enhancing life cycle chemical exposure assessment through ontology modeling. PMID:32050401
Identification of Drug-Disease Associations Using Information of Molecular Structures and Clinical Symptoms via Deep Convolutional Neural Network. PMID:31998700
Uncovering the Pharmacological Mechanism of Stemazole in the Treatment of Neurodegenerative Diseases Based on a Network Pharmacology Approach. PMID:31936558
Integrative Construction and Analysis of Molecular Association Network in Human Cells by Fusing Node Attribute and Behavior Information. PMID:31923739
Metabolomics and adductomics of newborn bloodspots to retrospectively assess the early-life exposome. PMID:31913157
Leveraging complementary computational models for prioritizing chemicals of developmental and reproductive toxicity concern: an example of food contact materials. PMID:31897520
MiRNA-disease interaction prediction based on kernel neighborhood similarity and multi-network bidirectional propagation. PMID:31865912
A network pharmacology approach to reveal the protective mechanism of Salvia miltiorrhiza-Dalbergia odorifera coupled-herbs on coronary heart disease. PMID:31852981
The human DEPhOsphorylation Database DEPOD: 2019 update. PMID:31836896
Network-Based Selection of Candidate Markers and Assays to Assess the Impact of Oral Immune Interventions on Gut Functions. PMID:31798593
Construction and Analysis of Molecular Association Network by Combining Behavior Representation and Node Attributes. PMID:31788002
An omics perspective on drug target discovery platforms. PMID:31774113
Discovery of disease- and drug-specific pathways through community structures of a literature network. PMID:31738408
Identification of the molecular mechanisms associated with acute type A aortic dissection through bioinformatics methods. PMID:31721906
Genetic Modifiers at the Crossroads of Personalised Medicine for Haemoglobinopathies. PMID:31717530
The Year of the Rat: The Rat Genome Database at 20: a multi-species knowledgebase and analysis platform. PMID:31713623
The Monarch Initiative in 2019: an integrative data and analytic platform connecting phenotypes to genotypes across species. PMID:31701156
TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP), A Novel Therapeutic Target Of Breast Cancer. PMID:31695491
Genetic Interactions Affect Lung Function in Patients with Systemic Sclerosis. PMID:31694854
Understanding allergic multimorbidity within the non-eosinophilic interactome. PMID:31693680
Cisplatin-resistant triple-negative breast cancer subtypes: multiple mechanisms of resistance. PMID:31684899
Network Pharmacology Reveals the Molecular Mechanism of Cuyuxunxi Prescription in Promoting Wound Healing in Patients with Anal Fistula. PMID:31636684
Polychlorinated biphenyl exposure and DNA methylation in the Anniston Community Health Survey. PMID:31607210
CancerGeneNet: linking driver genes to cancer hallmarks. PMID:31598703
A Computational Toxicology Approach to Screen the Hepatotoxic Ingredients in Traditional Chinese Medicines: Polygonum multiflorum Thunb as a Case Study. PMID:31591318
Graph embedding on biomedical networks: methods, applications and evaluations. PMID:31584634
Tandem RNA isolation reveals functional rearrangement of RNA-binding proteins on CDKN1B/p27Kip1 3'UTRs in cisplatin treated cells. PMID:31522610
Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients. PMID:31506599
Challenges in the construction of knowledge bases for human microbiome-disease associations. PMID:31488215
Construction and Comprehensive Analysis of a Molecular Association Network via lncRNA-miRNA -Disease-Drug-Protein Graph. PMID:31405040
Prediction and interpretation of miRNA-disease associations based on miRNA target genes using canonical correlation analysis. PMID:31345171
Identification and Interaction Analysis of Significant Genes and MicroRNAs in Pterygium. PMID:31341891
Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms. PMID:31332237
Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases. PMID:31323264
Long Noncoding RNA HCP5, a Hybrid HLA Class I Endogenous Retroviral Gene: Structure, Expression, and Disease Associations. PMID:31137555
In silico Identification and Mechanism Exploration of Hepatotoxic Ingredients in Traditional Chinese Medicine. PMID:31130860
NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis. PMID:30931480
A Novel Discovery: Holistic Efficacy at the Special Organ Level of Pungent Flavored Compounds from Pungent Traditional Chinese Medicine. PMID:30754631
Protective Effect of Salidroside Against Diabetic Kidney Disease Through Inhibiting BIM-Mediated Apoptosis of Proximal Renal Tubular Cells in Rats. PMID:30564128
The Comparative Toxicogenomics Database: update 2017 PubMed citations: 239.

239 articles citing: The Comparative Toxicogenomics Database: update 2017

Identifying Potential Effective Diagnostic and Prognostic Biomarkers in Sepsis by Bioinformatics Analysis and Validation. PMID:35832399
Identification of genes and key pathways underlying the pathophysiological association between nonalcoholic fatty liver disease and atrial fibrillation. PMID:35790963
In silico approaches in organ toxicity hazard assessment: Current status and future needs for predicting heart, kidney and lung toxicities. PMID:35721273
Mechanisms of Quercetin against atrial fibrillation explored by network pharmacology combined with molecular docking and experimental validation. PMID:35697725
Applications of knowledge graphs for food science and industry. PMID:35607620
Explore potential disease related metabolites based on latent factor model. PMID:35387615
PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool. PMID:35345455
In silico approaches in organ toxicity hazard assessment: current status and future needs in predicting liver toxicity. PMID:35340402
Network pharmacology and molecular docking analysis reveals the mechanism of asiaticoside on COVID-19. PMID:35280425
Emerging Bioinformatics Methods and Resources in Drug Toxicology. PMID:35188631
The p38 MAPK Components and Modulators as Biomarkers and Molecular Targets in Cancer. PMID:35008796
Manganese-Induced Neurotoxicity through Impairment of Cross-Talk Pathways in Human Neuroblastoma Cell Line SH-SY5Y Differentiated with Retinoic Acid. PMID:34941782
Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities. PMID:34705221
The Role of p38γ in Cancer: From review to outlook. PMID:34671218
Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species. PMID:34570764
DTi2Vec: Drug-target interaction prediction using network embedding and ensemble learning. PMID:34551818
[Exploring the therapeutic mechanism of quercetin for heart failure based on network pharmacology and molecular docking]. PMID:34549711
Bioinformatics analysis identified shared differentially expressed genes as potential biomarkers for Hashimoto's thyroiditis-related papillary thyroid cancer. PMID:34522174
Construction and investigation of a circRNA-associated ceRNA regulatory network in Tetralogy of Fallot. PMID:34521346
Predicting Target Genes of San-Huang-Chai-Zhu Formula in Treating ANIT-Induced Acute Intrahepatic Cholestasis Rat Model via Bioinformatics Analysis Combined with Experimental Validation. PMID:34512777
DTI-HeNE: a novel method for drug-target interaction prediction based on heterogeneous network embedding. PMID:34479477
Investigating the Mechanism of Scutellariae barbata Herba in the Treatment of Colorectal Cancer by Network Pharmacology and Molecular Docking. PMID:34381520
The 2021 update of the EPA's adverse outcome pathway database. PMID:34253739
A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank. PMID:34225788
DeepR2cov: deep representation learning on heterogeneous drug networks to discover anti-inflammatory agents for COVID-19. PMID:34117734
Extracellular Vesicle Proteome of Breast Cancer Patients with and Without Cognitive Impairment Following Anthracycline-based Chemotherapy: An Exploratory Study. PMID:34103887
Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis. PMID:34085602
MGRL: Predicting Drug-Disease Associations Based on Multi-Graph Representation Learning. PMID:34054920
Network Pharmacology and Molecular Docking Suggest the Mechanism for Biological Activity of Rosmarinic Acid. PMID:33936238
Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network. PMID:33893730
AutoDTI++: deep unsupervised learning for DTI prediction by autoencoders. PMID:33879050
Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury. PMID:33863396
Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach. PMID:33845901
Application of network link prediction in drug discovery. PMID:33845763
Network pharmacology-based and clinically relevant prediction of active ingredients and potential targets of Chinese herbs on stage IV lung adenocarcinoma patients. PMID:33797608
The impact of cesarean delivery on infant DNA methylation. PMID:33785011
NOGEA: A Network-oriented Gene Entropy Approach for Dissecting Disease Comorbidity and Drug Repositioning. PMID:33744433
A showcase study on personalized in silico drug response prediction based on the genetic landscape of muscle invasive bladder cancer. PMID:33712636
CID-GCN: An Effective Graph Convolutional Networks for Chemical-Induced Disease Relation Extraction. PMID:33643385
An In Silico Method for Predicting Drug Synergy Based on Multitask Learning. PMID:33611781
Integrative analysis of layers of data in hepatocellular carcinoma reveals pathway dependencies. PMID:33584989
Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology. PMID:33517789
Deep Learning applications for COVID-19. PMID:33457181
Network pharmacology modeling identifies synergistic interaction of therapeutic and toxicological mechanisms for Tripterygium hypoglaucum Hutch. PMID:33446184
DTiGEMS+: drug-target interaction prediction using graph embedding, graph mining, and similarity-based techniques. PMID:33431036
Learning important features from multi-view data to predict drug side effects. PMID:33430979
Formaldehyde and Brain Disorders: A Meta-Analysis and Bioinformatics Approach. PMID:33400181
Community Approaches for Integrating Environmental Exposures into Human Models of Disease. PMID:33369481
Identification and Characterization of Biomarkers and Their Role in Opioid Addiction by Integrated Bioinformatics Analysis. PMID:33328875
Integrated Analysis of Distant Metastasis-Associated Genes and Potential Drugs in Colon Adenocarcinoma. PMID:33194689
Nicotinamide N-Methyltransferase Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric Cancer. PMID:33193702
Analysis of the Components in Moxa Smoke by GC-MS and Preliminary Discussion on Its Toxicity and Side Effects. PMID:33178311
Systems pharmacology approach uncovers Ligustilide attenuates experimental colitis in mice by inhibiting PPARγ-mediated inflammation pathways. PMID:33130971
Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures. PMID:33121145
Preclinical validation of therapeutic targets predicted by tensor factorization on heterogeneous graphs. PMID:33106501
Comparative Toxicogenomics Database (CTD): update 2021. PMID:33068428
Beneficial Effects of Naringenin in Cigarette Smoke-Induced Damage to the Lung Based on Bioinformatic Prediction and In Vitro Analysis. PMID:33066647
Integrative transcriptomics analysis of lung epithelial cells and identification of repurposable drug candidates for COVID-19. PMID:32971089
NEDD: a network embedding based method for predicting drug-disease associations. PMID:32938396
Identification of Target Genes Related to Sulfasalazine in Triple-Negative Breast Cancer Through Network Pharmacology. PMID:32925871
Identification of differentially expressed genes between mucinous adenocarcinoma and other adenocarcinoma of colorectal cancer using bioinformatics analysis. PMID:32840168
Discovery of the possible mechanisms in kouyanqing granule for treatment of oral ulcers based on network pharmacology. PMID:32811507
Exploring Drug Treatment Patterns Based on the Action of Drug and Multilayer Network Model. PMID:32708644
Hsa_circ_0002320: a novel clinical biomarker for colorectal cancer prognosis. PMID:32664176
Identification of Target Genes in Hypertension and Left Ventricular Remodeling. PMID:32664164
Toward heterogeneous information fusion: bipartite graph convolutional networks for in silico drug repurposing. PMID:32657387
Impact of Hurricane Maria on Drinking Water Quality in Puerto Rico. PMID:32640159
cando.py: Open Source Software for Predictive Bioanalytics of Large Scale Drug-Protein-Disease Data. PMID:32515949
Systems Pharmacology-Dissection of the Molecular Mechanisms of Dragon's Blood in Improving Ischemic Stroke Prognosis. PMID:32508949
TinderMIX: Time-dose integrated modelling of toxicogenomics data. PMID:32449777
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker. PMID:32440005
ThETA: transcriptome-driven efficacy estimates for gene-based TArget discovery. PMID:32437556
Integrated Analysis of the Mechanisms of Da-Chai-Hu Decoction in Type 2 Diabetes Mellitus by a Network Pharmacology Approach. PMID:32419835
Integrating Genome-Wide Association Studies and Gene Expression Profiles With Chemical-Genes Interaction Networks to Identify Chemicals Associated With Colorectal Cancer. PMID:32391058
Predicting Drug-Disease Associations via Multi-Task Learning Based on Collective Matrix Factorization. PMID:32373595
Towards the routine use of in silico screenings for drug discovery using metabolic modelling. PMID:32369553
The EDCMET Project: Metabolic Effects of Endocrine Disruptors. PMID:32344727
PDZ Domains as Drug Targets. PMID:32313833
Ceramide launches an acute anti-adhesion pro-migration cell signaling program in response to chemotherapy. PMID:32307766
Novel application of normalized pointwise mutual information (NPMI) to mine biomedical literature for gene sets associated with disease: use case in breast carcinogenesis. PMID:32274464
Context-Specific Coordinately Regulatory Network Prioritize Breast Cancer Genetic Risk Factors. PMID:32273883
Identification of Co-expressed Genes Between Atrial Fibrillation and Stroke. PMID:32265825
Snorkel: rapid training data creation with weak supervision. PMID:32214778
Deciphering the Active Compounds and Mechanisms of Qixuehe Capsule on Qi Stagnation and Blood Stasis Syndrome: A Network Pharmacology Study. PMID:32190085
Identification of environmental chemicals targeting miscarriage genes and pathways using the comparative toxicogenomics database. PMID:32143025
Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease. PMID:32109936
Exploring Integrative Analysis Using the BioMedical Evidence Graph. PMID:32097025
Discovery of inflammatory bowel disease-associated miRNAs using a novel bipartite clustering approach. PMID:32093721
Poly-Enrich: count-based methods for gene set enrichment testing with genomic regions. PMID:32051932
Enhancing life cycle chemical exposure assessment through ontology modeling. PMID:32050401
A Novel Approach for Drug-Target Interactions Prediction Based on Multimodal Deep Autoencoder. PMID:32047432
Integrating Exposure Knowledge and Serum Suspect Screening as a New Approach to Biomonitoring: An Application in Firefighters and Office Workers. PMID:31971370
Open Data for Differential Network Analysis in Glioma. PMID:31952211
Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula. PMID:31949474
Identification of biological pathways and genes associated with neurogenic heterotopic ossification by text mining. PMID:31915578
A State-of-the-Science Review of Arsenic's Effects on Glucose Homeostasis in Experimental Models. PMID:31898917
Study on the Multitarget Mechanism and Key Active Ingredients of Herba Siegesbeckiae and Volatile Oil against Rheumatoid Arthritis Based on Network Pharmacology. PMID:31885670
Drug repositioning based on individual bi-random walks on a heterogeneous network. PMID:31874623
DDI-PULearn: a positive-unlabeled learning method for large-scale prediction of drug-drug interactions. PMID:31870276
Broad-Spectrum Profiling of Drug Safety via Learning Complex Network. PMID:31868917
Exploring Mechanistic Toxicity of Mixtures Using PBPK Modeling and Computational Systems Biology. PMID:31851354
The distributions of protein coding genes within chromatin domains in relation to human disease. PMID:31805995
LncDisAP: a computation model for LncRNA-disease association prediction based on multiple biological datasets. PMID:31787106
Snuba: Automating Weak Supervision to Label Training Data. PMID:31777681
An omics perspective on drug target discovery platforms. PMID:31774113
Identification of exosomal miR-455-5p and miR-1255a as therapeutic targets for breast cancer. PMID:31763681
Prioritizing candidate diseases-related metabolites based on literature and functional similarity. PMID:31760947
Mapping the perturbome network of cellular perturbations. PMID:31723137
Lipid Related Genes Altered in NASH Connect Inflammation in Liver Pathogenesis Progression to HCC: A Canonical Pathway. PMID:31717414
Cisplatin-resistant triple-negative breast cancer subtypes: multiple mechanisms of resistance. PMID:31684899
T1000: a reduced gene set prioritized for toxicogenomic studies. PMID:31681519
Computational Methods for Identifying Similar Diseases. PMID:31678735
The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways. PMID:31672983
Fingerprinting CANDO: Increased Accuracy with Structure- and Ligand-Based Shotgun Drug Repurposing. PMID:31656912
Pathway Commons 2019 Update: integration, analysis and exploration of pathway data. PMID:31647099
SSTR5‑AS1 functions as a ceRNA to regulate CA2 by sponging miR‑15b‑5p for the development and prognosis of HBV‑related hepatocellular carcinoma. PMID:31638225
A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages. PMID:31601718
A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. PMID:31494632
A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction. PMID:31490055
Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways. PMID:31453412
Global Text Mining and Development of Pharmacogenomic Knowledge Resource for Precision Medicine. PMID:31447668
lncRNA/circRNA‑miRNA‑mRNA ceRNA network in lumbar intervertebral disc degeneration. PMID:31432173
Progress in data interoperability to support computational toxicology and chemical safety evaluation. PMID:31404555
Identification of Biomarkers Related to Neuropathic Pain Induced by Peripheral Nerve Injury. PMID:31352588
CAGI5: Objective performance assessments of predictions based on the Evolutionary Action equation. PMID:31317604
Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactions. PMID:31310931
NGSEA: Network-Based Gene Set Enrichment Analysis for Interpreting Gene Expression Phenotypes with Functional Gene Sets. PMID:31307154
FoodOn: a harmonized food ontology to increase global food traceability, quality control and data integration. PMID:31304272
Inferring Regulatory Programs Governing Region Specificity of Neuroepithelial Stem Cells during Early Hindbrain and Spinal Cord Development. PMID:31302154
Predictive Analysis Using Chemical-Gene Interaction Networks Consistent with Observed Endocrine Activity and Mutagenicity of U.S. Streams. PMID:31287672
Centralized scientific communities are less likely to generate replicable results. PMID:31264964
Human exposure to trichloroethylene is associated with increased variability of blood DNA methylation that is enriched in genes and pathways related to autoimmune disease and cancer. PMID:31241004
BCScreen: A gene panel to test for breast carcinogenesis in chemical safety screening. PMID:31218268
Genome-wide Integrative Analysis of Zika-Virus-Infected Neuronal Stem Cells Reveals Roles for MicroRNAs in Cell Cycle and Stemness. PMID:31216479
Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology. PMID:31214028
Map and model-moving from observation to prediction in toxicogenomics. PMID:31140561
CODA-ML: context-specific biological knowledge representation for systemic physiology analysis. PMID:31138123
Multi-Omic Data Interpretation to Repurpose Subtype Specific Drug Candidates for Breast Cancer. PMID:31134131
Knowledge-guided convolutional networks for chemical-disease relation extraction. PMID:31113357
DigChem: Identification of disease-gene-chemical relationships from Medline abstracts. PMID:31091224
Genotify: Fast, lightweight gene lookup and summarization. PMID:31080942
Systematic elucidation of the mechanism of geraniol via network pharmacology. PMID:31040644
Navigating in vitro bioactivity data by investigating available resources using model compounds. PMID:31036807
Manganese-induced cellular disturbance in the baker's yeast, Saccharomyces cerevisiae with putative implications in neuronal dysfunction. PMID:31024033
Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach. PMID:30994381
Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species. PMID:30978202
Advancing Computational Toxicology in the Big Data Era by Artificial Intelligence: Data-Driven and Mechanism-Driven Modeling for Chemical Toxicity. PMID:30907586
Curating gene sets: challenges and opportunities for integrative analysis. PMID:30888410
CSgator: an integrated web platform for compound set analysis. PMID:30830479
Identification of biomarkers associated with the recurrence of osteosarcoma using ceRNA regulatory network analysis. PMID:30816442
Integrative Gene Selection on Gene Expression Data: Providing Biological Context to Traditional Approaches. PMID:30785707
Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke. PMID:30760287
Integrated curation and data mining for disease and phenotype models at the Rat Genome Database. PMID:30753478
Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological Relevance. PMID:30740124
Data mining for mutation-specific targets in acute myeloid leukemia. PMID:30728456
Sex-Dependent Sensory Phenotypes and Related Transcriptomic Expression Profiles Are Differentially Affected by Angelman Syndrome. PMID:30706369
Integrated analysis of lncRNA-associated ceRNA network reveals potential biomarkers for the prognosis of hepatitis B virus-related hepatocellular carcinoma. PMID:30697079
A Computational Framework for Genome-wide Characterization of the Human Disease Landscape. PMID:30685436
Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs). PMID:30679748
A distinct neurodevelopmental syndrome with intellectual disability, autism spectrum disorder, characteristic facies, and macrocephaly is caused by defects in CHD8. PMID:30670789
The Potential Mechanism of Bufadienolide-Like Chemicals on Breast Cancer via Bioinformatics Analysis. PMID:30646630
Inhibitor of DNA-Binding/Differentiation Proteins and Environmental Toxicants: Genomic Impact on the Onset of Depressive Dysfunction. PMID:30634536
Identification of conclusive association entities in biomedical articles. PMID:30616688
Predicting adverse drug reactions of combined medication from heterogeneous pharmacologic databases. PMID:30598065
BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. PMID:30576488
Drug-target-disease network analysis of gene-phenotype connectivity for genistein in ovarian cancer. PMID:30573976
iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data. PMID:30567491
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis. PMID:30554520
Integrating molecular networks with genetic variant interpretation for precision medicine. PMID:30548534
Chronic lifestyle diseases display seasonal sensitive comorbid trend in human population evidence from Google Trends. PMID:30540756
The BioGRID interaction database: 2019 update. PMID:30476227
Drug repositioning using drug-disease vectors based on an integrated network. PMID:30463505
ANCO-GeneDB: annotations and comprehensive analysis of candidate genes for alcohol, nicotine, cocaine and opioid dependence. PMID:30403795
Downregulation of miR-145-5p in cancer cells and their derived exosomes may contribute to the development of ovarian cancer by targeting CT. PMID:30365097
Quantitative and systems pharmacology 4. Network-based analysis of drug pleiotropy on coronary artery disease. PMID:30359818
Network-Based Methods for Prediction of Drug-Target Interactions. PMID:30356768
An Analytic Approach Using Candidate Gene Selection and Logic Forest to Identify Gene by Environment Interactions (G × E) for Systemic Lupus Erythematosus in African Americans. PMID:30326636
Network, Transcriptomic and Genomic Features Differentiate Genes Relevant for Drug Response. PMID:30319692
The Comparative Toxicogenomics Database: update 2019. PMID:30247620
Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction. PMID:30232231
Leptin receptor gene polymorphisms and sex modify the association between acetaminophen use and asthma among young adults: results from two observational studies. PMID:30231898
Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network. PMID:30125854
Machine Learning Based Toxicity Prediction: From Chemical Structural Description to Transcriptome Analysis. PMID:30103448
Computational resources associating diseases with genotypes, phenotypes and exposures. PMID:30102366
A Cloud-Based Metabolite and Chemical Prioritization System for the Biology/Disease-Driven Human Proteome Project. PMID:30094994
Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders. PMID:30081481
Chemical-induced disease extraction via recurrent piecewise convolutional neural networks. PMID:30066652
Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer's Disease. PMID:30050590
Automatic extraction of gene-disease associations from literature using joint ensemble learning. PMID:30048465
An integrative network-based approach to identify novel disease genes and pathways: a case study in the context of inflammatory bowel disease. PMID:30005591
A Computational Systems Pharmacology Approach to Investigate Molecular Mechanisms of Herbal Formula Tian-Ma-Gou-Teng-Yin for Treatment of Alzheimer's Disease. PMID:29997503
Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers. PMID:29991691
ChemDIS-Mixture: an online tool for analyzing potential interaction effects of chemical mixtures. PMID:29968796
Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data. PMID:29917034
Predicting drug-disease associations by using similarity constrained matrix factorization. PMID:29914348
Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis. PMID:29901120
Reverse Screening Methods to Search for the Protein Targets of Chemopreventive Compounds. PMID:29868550
Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways. PMID:29846728
Data-driven analysis of biomedical literature suggests broad-spectrum benefits of culinary herbs and spices. PMID:29813110
The relative resistance of children to sepsis mortality: from pathways to drug candidates. PMID:29773677
In Silico Pharmacoepidemiologic Evaluation of Drug-Induced Cardiovascular Complications Using Combined Classifiers. PMID:29712429
CTDquerier: a bioconductor R package for Comparative Toxicogenomics DatabaseTM data extraction, visualization and enrichment of environmental and toxicological studies. PMID:29688259
DR2DI: a powerful computational tool for predicting novel drug-disease associations. PMID:29687309
Transcriptional Responses Reveal Similarities Between Preclinical Rat Liver Testing Systems. PMID:29616076
Comprehensive analysis of Helicobacter pylori infection-associated diseases based on miRNA-mRNA interaction network. PMID:29579224
Transcriptomic characterization of MRI contrast with focus on the T1-w/T2-w ratio in the cerebral cortex. PMID:29567503
Ensemble of rankers for efficient gene signature extraction in smoke exposure classification. PMID:29536823
Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway. PMID:29517941
In Silico Prediction of Chemical Toxicity for Drug Design Using Machine Learning Methods and Structural Alerts. PMID:29515993
Molecular characterization of breast cancer cell response to metabolic drugs. PMID:29515760
Inhibitor of Differentiation-3 and Estrogenic Endocrine Disruptors: Implications for Susceptibility to Obesity and Metabolic Disorders. PMID:29507860
Petri net-based prediction of therapeutic targets that recover abnormally phosphorylated proteins in muscle atrophy. PMID:29506508
From gene networks to drugs: systems pharmacology approaches for AUD. PMID:29497781
Leveraging human genetic and adverse outcome pathway (AOP) data to inform susceptibility in human health risk assessment. PMID:29476236
AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks. PMID:29454060
Accessing an Expanded Exposure Science Module at the Comparative Toxicogenomics Database. PMID:29351546
Investigating the Mechanisms of Action of Depside Salt from Salvia miltiorrhiza Using Bioinformatic Analysis. PMID:29348768
Network perturbation analysis of gene transcriptional profiles reveals protein targets and mechanism of action of drugs and influenza A viral infection. PMID:29325153
Predicting drug-disease interactions by semi-supervised graph cut algorithm and three-layer data integration. PMID:29297383
Enhancing the Promise of Drug Repositioning through Genetics. PMID:29270124
The IDO inhibitor 1-methyl tryptophan activates the aryl hydrocarbon receptor response in mesenchymal stromal cells. PMID:29190885
DDR: efficient computational method to predict drug-target interactions using graph mining and machine learning approaches. PMID:29186331
In silico-based screen synergistic drug combinations from herb medicines: a case using Cistanche tubulosa. PMID:29180652
SuperDRUG2: a one stop resource for approved/marketed drugs. PMID:29140469
DrugBank 5.0: a major update to the DrugBank database for 2018. PMID:29126136
PedAM: a database for Pediatric Disease Annotation and Medicine. PMID:29126123
A Network Pharmacology Approach to Determine the Active Components and Potential Targets of Curculigo Orchioides in the Treatment of Osteoporosis. PMID:29074841
Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model. PMID:29036934
Environment and bladder cancer: molecular analysis by interaction networks. PMID:29029427
Identification of Linkages between EDCs in Personal Care Products and Breast Cancer through Data Integration Combined with Gene Network Analysis. PMID:28973975
Quantitative and Systems Pharmacology. 1. In Silico Prediction of Drug-Target Interactions of Natural Products Enables New Targeted Cancer Therapy. PMID:28956927
Comparative Study of Transcriptome Profiles of Mouse Livers and Skins Infected by Fork-Tailed or Non-Fork-Tailed Schistosoma japonicum. PMID:28912762
Rat Genome and Model Resources. PMID:28838068
The Exposome Paradigm in Human Health: Lessons from the Emory Exposome Summer Course. PMID:28669935
LimTox: a web tool for applied text mining of adverse event and toxicity associations of compounds, drugs and genes. PMID:28531339
A Review of Recent Advancement in Integrating Omics Data with Literature Mining towards Biomedical Discoveries. PMID:28331849
Functional Toxicogenomic Profiling Expands Insight into Modulators of Formaldehyde Toxicity in Yeast. PMID:27909446
Open Targets: a platform for therapeutic target identification and validation. PMID:27899665
The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species. PMID:27899636
The Comparative Toxicogenomics Database's 10th year anniversary: update 2015 PubMed citations: 184.

184 articles citing: The Comparative Toxicogenomics Database's 10th year anniversary: update 2015

A Text Mining Protocol for Extracting Drug-Drug Interaction and Adverse Drug Reactions Specific to Patient Population, Pharmacokinetics, Pharmacodynamics, and Disease. PMID:35713869
CXCR4 and TYROBP mediate the development of atrial fibrillation via inflammation. PMID:35607269
Cancer Comprehensive Analysis in Gastric Carcinoma: Benefits and New Perspectives. PMID:35082626
M2PP: a novel computational model for predicting drug-targeted pathogenic proteins. PMID:34983358
ELMO1 signaling is a promoter of osteoclast function and bone loss. PMID:34404802
Bioinformatics integrated analysis to investigate candidate biomarkers and associated metabolites in osteosarcoma. PMID:34225733
Target identification among known drugs by deep learning from heterogeneous networks. PMID:34123272
Predicting Drug-Disease Association Based on Ensemble Strategy. PMID:34012464
Prediction of Synergistic Drug Combinations for Prostate Cancer by Transcriptomic and Network Characteristics. PMID:33986671
Network Pharmacology and Molecular Docking Suggest the Mechanism for Biological Activity of Rosmarinic Acid. PMID:33936238
Ontology-driven weak supervision for clinical entity classification in electronic health records. PMID:33795682
CTD Anatomy: analyzing chemical-induced phenotypes and exposures from an anatomical perspective, with implications for environmental health studies. PMID:33768211
Public data sources to support systems toxicology applications. PMID:33604492
Predicting therapeutic drugs for hepatocellular carcinoma based on tissue-specific pathways. PMID:33561121
A review of computational drug repositioning: strategies, approaches, opportunities, challenges, and directions. PMID:33431024
Systematic Analysis of Protein-Protein and Gene-Environment Interactions to Decipher the Cognitive Mechanisms of Autism Spectrum Disorder. PMID:33165687
Comparative Toxicogenomics Database (CTD): update 2021. PMID:33068428
Environmental Impact on Male (In)Fertility via Epigenetic Route. PMID:32764255
Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene. PMID:32471155
Systematic Analysis of Environmental Chemicals That Dysregulate Critical Period Plasticity-Related Gene Expression Reveals Common Pathways That Mimic Immune Response to Pathogen. PMID:32454811
Clinical Bioinformatics in Precise Diagnosis of Mitochondrial Disease. PMID:32439066
The Role of Overexpressed Apolipoprotein AV in Insulin-Resistant Hepatocytes. PMID:32382544
CYP1B1, VEGFA, BCL2, and CDKN1A Affect the Development of Chronic Obstructive Pulmonary Disease. PMID:32158203
Predict New Therapeutic Drugs for Hepatocellular Carcinoma Based on Gene Mutation and Expression. PMID:32047745
Identification of infectious disease-associated host genes using machine learning techniques. PMID:31881961
Mechanistic insights into autocrine and paracrine roles of endothelial GABA signaling in the embryonic forebrain. PMID:31700116
IFN-γ enhances cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus. PMID:31554739
NERChem: adapting NERBio to chemical patents via full-token features and named entity feature with chemical sub-class composition. PMID:31414701
Predictive Analysis Using Chemical-Gene Interaction Networks Consistent with Observed Endocrine Activity and Mutagenicity of U.S. Streams. PMID:31287672
Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology. PMID:31214028
Analysis of disease organ as a novel phenotype towards disease genetics understanding. PMID:31207382
Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC. PMID:31031798
Mechanism-based disease similarity. PMID:30854526
The identification of gene signature and critical pathway associated with childhood-onset type 2 diabetes. PMID:30755828
INSIdE NANO: a systems biology framework to contextualize the mechanism-of-action of engineered nanomaterials. PMID:30655578
A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis. PMID:30643265
MicroRNA Expression Profiles Identify Biomarker for Differentiating the Embolic Stroke from Thrombotic Stroke. PMID:30627556
Constructing a database for the relations between CNV and human genetic diseases via systematic text mining. PMID:30598077
Statistical principle-based approach for gene and protein related object recognition. PMID:30560325
Extraction of Information Related to Adverse Drug Events from Electronic Health Record Notes: Design of an End-to-End Model Based on Deep Learning. PMID:30478023
Bioinformatics-based study to detect chemical compounds that show potential as treatments for pulmonary thromboembolism. PMID:30431066
The Pathogenesis of Atherosclerosis Based on Human Signaling Networks and Stem Cell Expression Data. PMID:30416382
Integrative bioinformatics identifies postnatal lead (Pb) exposure disrupts developmental cortical plasticity. PMID:30401819
Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs. PMID:30385774
LPTK: a linguistic pattern-aware dependency tree kernel approach for the BioCreative VI CHEMPROT task. PMID:30346607
Drug Repurposing Prediction for Immune-Mediated Cutaneous Diseases using a Word-Embedding-Based Machine Learning Approach. PMID:30342048
Multimodal network diffusion predicts future disease-gene-chemical associations. PMID:30304494
The Comparative Toxicogenomics Database: update 2019. PMID:30247620
PTMD: A Database of Human Disease-associated Post-translational Modifications. PMID:30244175
A document level neural model integrated domain knowledge for chemical-induced disease relations. PMID:30223767
Prediction of Novel Drugs and Diseases for Hepatocellular Carcinoma Based on Multi-Source Simulated Annealing Based Random Walk. PMID:30173379
Identification of potential key genes associated with severe pneumonia using mRNA-seq. PMID:30112034
Phenotype-oriented network analysis for discovering pharmacological effects of natural compounds. PMID:30076354
Liuwei Dihuang pill cures postmenopausal osteoporosis with kidney-Yin deficiency: Potential therapeutic targets identified based on gene expression profiling. PMID:30075554
KampoDB, database of predicted targets and functional annotations of natural medicines. PMID:30046160
Candidate gene and mechanism investigations in congenital obstructive nephropathy based on bioinformatics analysis. PMID:30015886
Network-based approach to prediction and population-based validation of in silico drug repurposing. PMID:30002366
ANTENNA, a Multi-Rank, Multi-Layered Recommender System for Inferring Reliable Drug-Gene-Disease Associations: Repurposing Diazoxide as a Targeted Anti-Cancer Therapy. PMID:29993812
Predicting Potential Drugs for Breast Cancer based on miRNA and Tissue Specificity. PMID:29989066
MicroRNA expression profiles identify biomarkers for predicting the response to chemoradiotherapy in rectal cancer. PMID:29956755
Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology. PMID:29932108
Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data. PMID:29917034
Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways. PMID:29846728
Towards Optimal Connectivity on Multi-layered Networks. PMID:29755246
In Silico Investigation of the Pharmacological Mechanisms of Beneficial Effects of Ginkgo biloba L. on Alzheimer's Disease. PMID:29747475
CTDquerier: a bioconductor R package for Comparative Toxicogenomics DatabaseTM data extraction, visualization and enrichment of environmental and toxicological studies. PMID:29688259
Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma. PMID:29615643
Quantitative Proteomics of Synaptosomal Fractions in a Rat Overexpressing Human DISC1 Gene Indicates Profound Synaptic Dysregulation in the Dorsal Striatum. PMID:29467617
Gene annotation bias impedes biomedical research. PMID:29358745
Accessing an Expanded Exposure Science Module at the Comparative Toxicogenomics Database. PMID:29351546
NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations. PMID:29220444
Predicting new indications of compounds with a network pharmacology approach: Liuwei Dihuang Wan as a case study. PMID:29212201
Cross-Dependency Inference in Multi-Layered Networks: A Collaborative Filtering Perspective. PMID:29204108
Investigation of candidate genes and mechanisms underlying postmenopausal osteoporosis using bioinformatics analysis. PMID:29138843
Context-dependent compensation among phosphatidylserine-recognition receptors. PMID:29116131
Bioinformatic Analysis Identifies Three Potentially Key Differentially Expressed Genes in Peripheral Blood Mononuclear Cells of Patients with Takayasu's Arteritis. PMID:29105401
Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior. PMID:29086765
Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases. PMID:28978193
Screening critical genes associated with malignant glioma using bioinformatics analysis. PMID:28901452
Identification of informative features for predicting proinflammatory potentials of engine exhausts. PMID:28830522
Identification of key genes and pathways associated with obesity in children. PMID:28810559
Towards a more molecular taxonomy of disease. PMID:28750648
Assessment of the DNA damaging potential of environmental chemicals using a quantitative high-throughput screening approach to measure p53 activation. PMID:28714573
RGIFE: a ranked guided iterative feature elimination heuristic for the identification of biomarkers. PMID:28666416
Prioritization of Contaminants of Emerging Concern in Wastewater Treatment Plant Discharges Using Chemical:Gene Interactions in Caged Fish. PMID:28651047
Machine learning workflow to enhance predictions of Adverse Drug Reactions (ADRs) through drug-gene interactions: application to drugs for cutaneous diseases. PMID:28623363
Genetic background influences susceptibility to chemotherapy-induced hematotoxicity. PMID:28607509
DrugSig: A resource for computational drug repositioning utilizing gene expression signatures. PMID:28562632
Candidate miRNAs and pathogenesis investigation for hepatocellular carcinoma based on bioinformatics analysis. PMID:28521446
High-Throughput Screening Data Interpretation in the Context of In Vivo Transcriptomic Responses to Oral Cr(VI) Exposure. PMID:28472532
Comprehensive strategy for the design of precision drugs and identification of genetic signature behind proneness of the disease-a pharmacogenomic approach. PMID:28470340
Mapping genes for calcium signaling and their associated human genetic disorders. PMID:28430858
Network-based analysis of transcriptional profiles from chemical perturbations experiments. PMID:28361664
A neural joint model for entity and relation extraction from biomedical text. PMID:28359255
Improving chemical disease relation extraction with rich features and weakly labeled data. PMID:28316651
Microarray technology reveals potentially novel genes and pathways involved in non-functioning pituitary adenomas. PMID:28289583
Applying evolutionary genetics to developmental toxicology and risk assessment. PMID:28267574
Drug voyager: a computational platform for exploring unintended drug action. PMID:28241745
Network pharmacology-based and clinically relevant prediction of the active ingredients and potential targets of Chinese herbs in metastatic breast cancer patients. PMID:28212580
A Comprehensive Gene Expression Meta-analysis Identifies Novel Immune Signatures in Rheumatoid Arthritis Patients. PMID:28210261
The extraction of drug-disease correlations based on module distance in incomplete human interactome. PMID:28155709
Protein Bioinformatics Databases and Resources. PMID:28150231
Identification of shared and unique gene families associated with oral clefts. PMID:28106045
A Systems Approach Implicates a Brain Mitochondrial Oxidative Homeostasis Co-expression Network in Genetic Vulnerability to Alcohol Withdrawal. PMID:28096806
Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health. PMID:28068484
DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds. PMID:28032149
Disentangling genetic and environmental risk factors for individual diseases from multiplex comorbidity networks. PMID:28008973
The BioGRID interaction database: 2017 update. PMID:27980099
Exposome-Explorer: a manually-curated database on biomarkers of exposure to dietary and environmental factors. PMID:27924041
DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants. PMID:27924018
CEBS: a comprehensive annotated database of toxicological data. PMID:27899660
MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search. PMID:27899610
ToxReporter: viewing the genome through the eyes of a toxicologist. PMID:27888230
A review of validation strategies for computational drug repositioning. PMID:27881429
An integrated approach for identifying priority contaminant in the Great Lakes Basin - Investigations in the Lower Green Bay/Fox River and Milwaukee Estuary areas of concern. PMID:27866739
Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data. PMID:27840954
Exploring human disease using the Rat Genome Database. PMID:27736745
Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing. PMID:27716836
Drug repurposing for glioblastoma based on molecular subtypes. PMID:27697594
Prediction of new drug indications based on clinical data and network modularity. PMID:27678071
Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice. PMID:27655631
The Comparative Toxicogenomics Database: update 2017. PMID:27651457
A Network-Based Data Integration Approach to Support Drug Repurposing and Multi-Target Therapies in Triple Negative Breast Cancer. PMID:27632168
Functional networks inference from rule-based machine learning models. PMID:27597880
Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection. PMID:27488578
Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish. PMID:27462272
Investigation of 7-dehydrocholesterol reductase pathway to elucidate off-target prenatal effects of pharmaceuticals: a systematic review. PMID:27401223
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. PMID:27374120
Bisphenol A-associated alterations in genome-wide DNA methylation and gene expression patterns reveal sequence-dependent and non-monotonic effects in human fetal liver. PMID:27358748
Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17β-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas). PMID:27312088
Jumping across biomedical contexts using compressive data fusion. PMID:27307649
Network Analysis of Genome-Wide Selective Constraint Reveals a Gene Network Active in Early Fetal Brain Intolerant of Mutation. PMID:27305007
Literature information in PubChem: associations between PubChem records and scientific articles. PMID:27293485
AuDis: an automatic CRF-enhanced disease normalization in biomedical text. PMID:27278815
HITSZ_CDR: an end-to-end chemical and disease relation extraction system for BioCreative V. PMID:27270713
Review on Graph Clustering and Subgraph Similarity Based Analysis of Neurological Disorders. PMID:27258269
CART-a chemical annotation retrieval toolkit. PMID:27256313
Data integration to prioritize drugs using genomics and curated data. PMID:27231484
Research Resources for Nuclear Receptor Signaling Pathways. PMID:27216565
An Integrated Data Driven Approach to Drug Repositioning Using Gene-Disease Associations. PMID:27196054
A knowledge-poor approach to chemical-disease relation extraction. PMID:27189609
The Chinchilla Research Resource Database: resource for an otolaryngology disease model. PMID:27173523
Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database. PMID:27171405
Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database. PMID:27170236
Candidate gene networks and blood biomarkers of methamphetamine-associated psychosis: an integrative RNA-sequencing report. PMID:27163203
BioCreative V CDR task corpus: a resource for chemical disease relation extraction. PMID:27161011
ToxEvaluator: an integrated computational platform to aid the interpretation of toxicology study-related findings. PMID:27161010
The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions. PMID:27091369
ChemiRs: a web application for microRNAs and chemicals. PMID:27091357
A crowdsourcing workflow for extracting chemical-induced disease relations from free text. PMID:27087308
MBROLE 2.0-functional enrichment of chemical compounds. PMID:27084944
Chemical-induced disease relation extraction with various linguistic features. PMID:27052618
CD-REST: a system for extracting chemical-induced disease relation in literature. PMID:27016700
Proteomic Profiling of Mouse Liver following Acute Toxoplasma gondii Infection. PMID:27003162
Assessing the state of the art in biomedical relation extraction: overview of the BioCreative V chemical-disease relation (CDR) task. PMID:26994911
An integrative data analysis platform for gene set analysis and knowledge discovery in a data warehouse framework. PMID:26989145
MSeqDR: A Centralized Knowledge Repository and Bioinformatics Web Resource to Facilitate Genomic Investigations in Mitochondrial Disease. PMID:26919060
Laying a Community-Based Foundation for Data-Driven Semantic Standards in Environmental Health Sciences. PMID:26871594
ksRepo: a generalized platform for computational drug repositioning. PMID:26860211
Cell type-specific properties and environment shape tissue specificity of cancer genes. PMID:26856619
Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking. PMID:26837704
Analytical Complexity in Detection of Gene Variant-by-Environment Exposure Interactions in High-Throughput Genomic and Exposomic Research. PMID:26809563
Accelerating Adverse Outcome Pathway Development Using Publicly Available Data Sources. PMID:26809562
Semantic interrogation of a multi knowledge domain ontological model of tendinopathy identifies four strong candidate risk genes. PMID:26804977
COLLECTIVE PAIRWISE CLASSIFICATION FOR MULTI-WAY ANALYSIS OF DISEASE AND DRUG DATA. PMID:26776175
COMPUTING THERAPY FOR PRECISION MEDICINE: COLLABORATIVE FILTERING INTEGRATES AND PREDICTS MULTI-ENTITY INTERACTIONS. PMID:26776170
Prediction of disease-gene-drug relationships following a differential network analysis. PMID:26775695
Identifying communities from multiplex biological networks. PMID:26713261
Leveraging big data to transform target selection and drug discovery. PMID:26659699
The estrous cycle surpasses sex differences in regulating the transcriptome in the rat medial prefrontal cortex and reveals an underlying role of early growth response 1. PMID:26628058
CancerResource--updated database of cancer-relevant proteins, mutations and interacting drugs. PMID:26590406
Lynx: a knowledge base and an analytical workbench for integrative medicine. PMID:26590263
STITCH 5: augmenting protein-chemical interaction networks with tissue and affinity data. PMID:26590256
PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine. PMID:26555441
WITHDRAWN--a resource for withdrawn and discontinued drugs. PMID:26553801
DMAP: a connectivity map database to enable identification of novel drug repositioning candidates. PMID:26423722
Recent Advances and Emerging Applications in Text and Data Mining for Biomedical Discovery. PMID:26420781
Cell type-selective disease-association of genes under high regulatory load. PMID:26338775
Assessing the Need of Discourse-Level Analysis in Identifying Evidence of Drug-Disease Relations in Scientific Literature. PMID:26262109
GeneWeaver: finding consilience in heterogeneous cross-species functional genomics data. PMID:26092690
ChemDIS: a chemical-disease inference system based on chemical-protein interactions. PMID:26078786
Colorectal cancer drug target prediction using ontology-based inference and network analysis. PMID:25818893
A miRNA-driven inference model to construct potential drug-disease associations for drug repositioning. PMID:25789319
The 2015 Nucleic Acids Research Database Issue and molecular biology database collection. PMID:25593347
The Comparative Toxicogenomics Database: update 2013 PubMed citations: 160.

160 articles citing: The Comparative Toxicogenomics Database: update 2013

Metapath Aggregated Graph Neural Network and Tripartite Heterogeneous Networks for Microbe-Disease Prediction. PMID:35711758
Integrative analysis prioritised oxytocin-related biomarkers associated with the aetiology of autism spectrum disorder. PMID:35665681
HGDTI: predicting drug-target interaction by using information aggregation based on heterogeneous graph neural network. PMID:35413800
HIDTI: integration of heterogeneous information to predict drug-target interactions. PMID:35260608
Trends in the Application of "Omics" to Ecotoxicology and Stress Ecology. PMID:34680873
Drug-Drug Interaction Predictions via Knowledge Graph and Text Embedding: Instrument Validation Study. PMID:34185011
Transcriptional drug repositioning and cheminformatics approach for differentiation therapy of leukaemia cells. PMID:34131166
LUNAR :Drug Screening for Novel Coronavirus Based on Representation Learning Graph Convolutional Network. PMID:34081583
Multiscale Virtual Screening Optimization for Shotgun Drug Repurposing Using the CANDO Platform. PMID:33925237
GADTI: Graph Autoencoder Approach for DTI Prediction From Heterogeneous Network. PMID:33912218
Association of microbiota-derived propionic acid and Alzheimer's disease; bioinformatics analysis. PMID:33553012
Screening of disease-related biomarkers related to neuropathic pain (NP) after spinal cord injury (SCI). PMID:33494823
An empirical meta-analysis of the life sciences linked open data on the web. PMID:33479214
Comparative Toxicogenomics Database (CTD): update 2021. PMID:33068428
Named Entity Recognition and Relation Detection for Biomedical Information Extraction. PMID:32984300
Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning. PMID:32967266
A learning-based method for drug-target interaction prediction based on feature representation learning and deep neural network. PMID:32938374
Genetic variation regulates opioid-induced respiratory depression in mice. PMID:32917924
Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment. PMID:32656498
Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene. PMID:32471155
Integrating Genome-Wide Association Studies and Gene Expression Profiles With Chemical-Genes Interaction Networks to Identify Chemicals Associated With Colorectal Cancer. PMID:32391058
Predicting Drug-Disease Associations via Multi-Task Learning Based on Collective Matrix Factorization. PMID:32373595
Integrated analysis of DNA methylation and transcriptome profiling of polycystic ovary syndrome. PMID:32323770
Role of the XIST-miR-181a-COL4A1 axis in the development and progression of keratoconus. PMID:32165822
PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata. PMID:31998395
Systematic analysis of lncRNA and microRNA dynamic features reveals diagnostic and prognostic biomarkers of myocardial infarction. PMID:31927529
Overlap matrix completion for predicting drug-associated indications. PMID:31869322
Predicting associations among drugs, targets and diseases by tensor decomposition for drug repositioning. PMID:31839008
Network Pharmacology of Yougui Pill Combined with Buzhong Yiqi Decoction for the Treatment of Sexual Dysfunction. PMID:31814838
Systems Pharmacology-Based Method to Assess the Mechanism of Action of Weight-Loss Herbal Intervention Therapy for Obesity. PMID:31680953
Enabling Web-scale data integration in biomedicine through Linked Open Data. PMID:31531395
Drug repositioning based on bounded nuclear norm regularization. PMID:31510658
Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways. PMID:31453412
Comparison of Target Features for Predicting Drug-Target Interactions by Deep Neural Network Based on Large-Scale Drug-Induced Transcriptome Data. PMID:31382356
Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases. PMID:31323264
Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactions. PMID:31310931
T cell receptor signaling pathway and cytokine-cytokine receptor interaction affect the rehabilitation process after respiratory syncytial virus infection. PMID:31223533
Revealing Drug-Target Interactions with Computational Models and Algorithms. PMID:31052598
Relation path feature embedding based convolutional neural network method for drug discovery. PMID:30961599
Transcriptome Analysis of the Human Tibial Nerve Identifies Sexually Dimorphic Expression of Genes Involved in Pain, Inflammation, and Neuro-Immunity. PMID:30890918
Conserved Disease Modules Extracted From Multilayer Heterogeneous Disease and Gene Networks for Understanding Disease Mechanisms and Predicting Disease Treatments. PMID:30713550
Network Analysis Reveals TNF as a Major Hub of Reactive Inflammation Following Spinal Cord Injury. PMID:30700814
Identifying Protein Features Responsible for Improved Drug Repurposing Accuracies Using the CANDO Platform: Implications for Drug Design. PMID:30621144
A Novel Systems Pharmacology Method to Investigate Molecular Mechanisms of Scutellaria barbata D. Don for Non-small Cell Lung Cancer. PMID:30618763
Systematic identification and analysis of dysregulated miRNA and transcription factor feed-forward loops in hypertrophic cardiomyopathy. PMID:30338905
Deep learning-based transcriptome data classification for drug-target interaction prediction. PMID:30255785
The Comparative Toxicogenomics Database: update 2019. PMID:30247620
Biomarker identification of thyroid associated ophthalmopathy using microarray data. PMID:30225222
Predicting Adverse Drug Effects from Literature- and Database-Mined Assertions. PMID:29876834
Mechanism-based Pharmacovigilance over the Life Sciences Linked Open Data Cloud. PMID:29854169
Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways. PMID:29846728
A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer. PMID:29614978
PhLeGrA: Graph Analytics in Pharmacology over the Web of Life Sciences Linked Open Data. PMID:29479581
Identification of methylated genes and miRNA signatures in nasopharyngeal carcinoma by bioinformatics analysis. PMID:29393436
Systems pharmacology analysis of synergy of TCM: an example using saffron formula. PMID:29321678
DisSetSim: an online system for calculating similarity between disease sets. PMID:29297411
Measuring disease similarity and predicting disease-related ncRNAs by a novel method. PMID:29297338
Mining significant high utility gene regulation sequential patterns. PMID:29297335
miRDDCR: a miRNA-based method to comprehensively infer drug-disease causal relationships. PMID:29162848
BARHL1 Is Downregulated in Alzheimer's Disease and May Regulate Cognitive Functions through ESR1 and Multiple Pathways. PMID:28956815
A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information. PMID:28924171
Domain-based prediction of the human isoform interactome provides insights into the functional impact of alternative splicing. PMID:28846689
A computational method for the identification of candidate drugs for non-small cell lung cancer. PMID:28820893
Computational analysis of multimorbidity between asthma, eczema and rhinitis. PMID:28598986
A Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In Vitro. PMID:28587163
Network mirroring for drug repositioning. PMID:28539121
Recent advances in predicting gene-disease associations. PMID:28529714
Gene ORGANizer: linking genes to the organs they affect. PMID:28444223
The Key Genes of Chronic Pancreatitis which Bridge Chronic Pancreatitis and Pancreatic Cancer Can be Therapeutic Targets. PMID:28435988
Cross disease analysis of co-functional microRNA pairs on a reconstructed network of disease-gene-microRNA tripartite. PMID:28340554
In silico search for modifier genes associated with pancreatic and liver disease in Cystic Fibrosis. PMID:28339466
How consistent are we? Interlaboratory comparison study in fathead minnows using the model estrogen 17α-ethinylestradiol to develop recommendations for environmental transcriptomics. PMID:28316117
FocusHeuristics - expression-data-driven network optimization and disease gene prediction. PMID:28205611
From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration. PMID:28185567
DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer. PMID:28120820
Toward a comprehensive drug ontology: extraction of drug-indication relations from diverse information sources. PMID:28069052
The 24th annual Nucleic Acids Research database issue: a look back and upcoming changes. PMID:28053160
Carbamate Insecticides Target Human Melatonin Receptors. PMID:28027439
Prior knowledge-based approach for associating contaminants with biological effects: A case study in the St. Croix River basin, MN, WI, USA. PMID:27939634
Systems pharmacology exploration of botanic drug pairs reveals the mechanism for treating different diseases. PMID:27841365
Harnessing Big Data for Systems Pharmacology. PMID:27814027
Mining kidney toxicogenomic data by using gene co-expression modules. PMID:27724849
The Comparative Toxicogenomics Database: update 2017. PMID:27651457
Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine. PMID:27597117
Fusing literature and full network data improves disease similarity computation. PMID:27578323
Systematic selection of small molecules to promote differentiation of embryonic stem cells and experimental validation for generating cardiomyocytes. PMID:27551501
Gene-Disease Interaction Retrieval from Multiple Sources: A Network Based Method. PMID:27478829
DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs. PMID:27457921
Investigation of potential molecular biomarkers and small molecule drugs for hepatocellular carcinoma transformed from cirrhosis. PMID:27347171
Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database. PMID:27171405
DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing. PMID:27151405
Identifying novel genes and chemicals related to nasopharyngeal cancer in a heterogeneous network. PMID:27149165
Drug Repositioning for Cancer Therapy Based on Large-Scale Drug-Induced Transcriptional Signatures. PMID:26954019
Cross-Species Integrative Functional Genomics in GeneWeaver Reveals a Role for Pafah1b1 in Altered Response to Alcohol. PMID:26834590
In Silico Insight into Potential Anti-Alzheimer's Disease Mechanisms of Icariin. PMID:26784184
Network Analysis of Human Genes Influencing Susceptibility to Mycobacterial Infections. PMID:26751573
An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases. PMID:26575483
Identifying New Candidate Genes and Chemicals Related to Prostate Cancer Using a Hybrid Network and Shortest Path Approach. PMID:26504486
Methods for biological data integration: perspectives and challenges. PMID:26490630
Molecular mechanisms of D-cycloserine in facilitating fear extinction: insights from RNAseq. PMID:26400817
MicroRNA and transcription factor mediated regulatory network analysis reveals critical regulators and regulatory modules in myocardial infarction. PMID:26258537
miRegulome: a knowledge-base of miRNA regulomics and analysis. PMID:26243198
RepurposeVS: A Drug Repurposing-Focused Computational Method for Accurate Drug-Target Signature Predictions. PMID:26234515
The support of human genetic evidence for approved drug indications. PMID:26121088
Metrabase: a cheminformatics and bioinformatics database for small molecule transporter data analysis and (Q)SAR modeling. PMID:26106450
Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM. PMID:26101539
Identification of New Candidate Genes and Chemicals Related to Esophageal Cancer Using a Hybrid Interaction Network of Chemicals and Proteins. PMID:26058041
DeCoaD: determining correlations among diseases using protein interaction networks. PMID:26047952
The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer. PMID:26047514
Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. PMID:26039340
Network-based inference methods for drug repositioning. PMID:25969690
PsyGeNET: a knowledge platform on psychiatric disorders and their genes. PMID:25964630
A modularity-based method reveals mixed modules from chemical-gene heterogeneous network. PMID:25927435
Understanding multicellular function and disease with human tissue-specific networks. PMID:25915600
DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes. PMID:25877637
Identification of novel thyroid cancer-related genes and chemicals using shortest path algorithm. PMID:25874234
Optimising chemical named entity recognition with pre-processing analytics, knowledge-rich features and heuristics. PMID:25810777
Investigating the utility of clinical outcome-guided mutual information network in network-based Cox regression. PMID:25708115
Multiscale modelling of relationships between protein classes and drug behavior across all diseases using the CANDO platform. PMID:25694071
Crucial microRNAs and genes of human primary breast cancer explored by microRNA-mRNA integrated analysis. PMID:25680412
Promoting Precision Cancer Medicine through a Community-Driven Knowledgebase. PMID:25563458
In silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases. PMID:25486901
Prenatal exposure to arsenic and cadmium impacts infectious disease-related genes within the glucocorticoid receptor signal transduction pathway. PMID:25479081
A chemo-centric view of human health and disease. PMID:25435099
AlzBase: an Integrative Database for Gene Dysregulation in Alzheimer's Disease. PMID:25432889
Proteomics-Based Identification of Differentially Abundant Proteins from Human Keratinocytes Exposed to Arsenic Trioxide. PMID:25419056
DDMGD: the database of text-mined associations between genes methylated in diseases from different species. PMID:25398897
Systems level analysis and identification of pathways and networks associated with liver fibrosis. PMID:25380136
T3DB: the toxic exposome database. PMID:25378312
Human cancer databases (review). PMID:25369839
Relating diseases by integrating gene associations and information flow through protein interaction network. PMID:25360770
The Rat Genome Database 2015: genomic, phenotypic and environmental variations and disease. PMID:25355511
Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data. PMID:25348409
Workshop report: Identifying opportunities for global integration of toxicogenomics databases, 26-27 June 2013, Research Triangle Park, NC, USA. PMID:25326818
The Comparative Toxicogenomics Database's 10th year anniversary: update 2015. PMID:25326323
Open TG-GATEs: a large-scale toxicogenomics database. PMID:25313160
Organ system heterogeneity DB: a database for the visualization of phenotypes at the organ system level. PMID:25313158
Characterization of chemically induced liver injuries using gene co-expression modules. PMID:25226513
Genome-wide association study combined with biological context can reveal more disease-related SNPs altering microRNA target seed sites. PMID:25106527
Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action. PMID:25058030
BioC interoperability track overview. PMID:24980129
SemFunSim: a new method for measuring disease similarity by integrating semantic and gene functional association. PMID:24932637
Web services-based text-mining demonstrates broad impacts for interoperability and process simplification. PMID:24919658
Finding novel molecular connections between developmental processes and disease. PMID:24874013
BioCreative-IV virtual issue. PMID:24852177
Alkemio: association of chemicals with biomedical topics by text and data mining. PMID:24838570
An extensive analysis of disease-gene associations using network integration and fast kernel-based gene prioritization methods. PMID:24726035
What's that gene (or protein)? Online resources for exploring functions of genes, transcripts, and proteins. PMID:24723265
Drug2Gene: an exhaustive resource to explore effectively the drug-target relation network. PMID:24618344
Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination. PMID:24367114
Differential network analysis applied to preoperative breast cancer chemotherapy response. PMID:24349128
STITCH 4: integration of protein-chemical interactions with user data. PMID:24293645
A CTD-Pfizer collaboration: manual curation of 88,000 scientific articles text mined for drug-disease and drug-phenotype interactions. PMID:24288140
DGIdb: mining the druggable genome. PMID:24122041
BioC: a minimalist approach to interoperability for biomedical text processing. PMID:24048470
Prediction of microRNAs associated with human diseases based on weighted k most similar neighbors. PMID:23950912
Genome-wide identification of molecular pathways and biomarkers in response to arsenic exposure in zebrafish liver. PMID:23922661
Analysis of the transcriptome in molecular epidemiology studies. PMID:23907930
Cataloging the biomedical world of pain through semi-automated curation of molecular interactions. PMID:23707966
MalaCards: an integrated compendium for diseases and their annotation. PMID:23584832
Comparative Toxicogenomics Database (CTD): update 2021 PubMed citations: 123.

123 articles citing: Comparative Toxicogenomics Database (CTD): update 2021

The Construction and Analysis of Infiltrating Immune Cell and ceRNA Networks in Diabetic Foot Ulcer. PMID:35909542
Analyzing the Systems Biology Effects of COVID-19 mRNA Vaccines to Assess Their Safety and Putative Side Effects. PMID:35889989
Identification of MiRNA-Disease Associations Based on Information of Multi-Module and Meta-Path. PMID:35889314
Multi-Level Biological Network Analysis and Drug Repurposing Based on Leukocyte Transcriptomics in Severe COVID-19: In Silico Systems Biology to Precision Medicine. PMID:35887528
A Narrative Literature Review of Natural Language Processing Applied to the Occupational Exposome. PMID:35886395
Drug-Target Network Study Reveals the Core Target-Protein Interactions of Various COVID-19 Treatments. PMID:35885993
Active ingredients and molecular targets of Taraxacum mongolicum against hepatocellular carcinoma: network pharmacology, molecular docking, and molecular dynamics simulation analysis. PMID:35873910
NTD-DR: Nonnegative tensor decomposition for drug repositioning. PMID:35862409
A sequence labeling framework for extracting drug-protein relations from biomedical literature. PMID:35856889
A Discovery Strategy for Active Compounds of Chinese Medicine Based on the Prediction Model of Compound-Disease Relationship. PMID:35847368
Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration. PMID:35840955
Identification and Validation of Prognostic Related Hallmark ATP-Binding Cassette Transporters Associated With Immune Cell Infiltration Patterns in Thyroid Carcinoma. PMID:35837087
The heterogeneous pharmacological medical biochemical network PharMeBINet. PMID:35821017
The Pharmacological Mechanism of Xiyanping Injection for the Treatment of Novel Coronavirus Pneumonia (COVID-19): Based on Network Pharmacology Strategy. PMID:35818408
Development of the InTelligence And Machine LEarning (TAME) Toolkit for Introductory Data Science, Chemical-Biological Analyses, Predictive Modeling, and Database Mining for Environmental Health Research. PMID:35812168
Network-Based Approaches for Disease-Gene Association Prediction Using Protein-Protein Interaction Networks. PMID:35806415
Network Pharmacology-Based Strategy to Investigate the Pharmacologic Mechanisms of Coptidis Rhizoma for the Treatment of Alzheimer's Disease. PMID:35795239
Metabolic modeling-based drug repurposing in Glioblastoma. PMID:35778411
Chemical identification and indexing in PubMed full-text articles using deep learning and heuristics. PMID:35776534
Identification of Serum Exosome-Derived circRNA-miRNA-TF-mRNA Regulatory Network in Postmenopausal Osteoporosis Using Bioinformatics Analysis and Validation in Peripheral Blood-Derived Mononuclear Cells. PMID:35757392
Construction of Immune-Related ceRNA Network in Dilated Cardiomyopathy: Based on Sex Differences. PMID:35754849
Modeling Kaempferol as a Potential Pharmacological Agent for COVID-19/PF Co-Occurrence Based on Bioinformatics and System Pharmacological Tools. PMID:35754492
Differential vulnerability of anterior cingulate cortex cell types to diseases and drugs. PMID:35754044
AddictedChem: A Data-Driven Integrated Platform for New Psychoactive Substance Identification. PMID:35745053
DACPGTN: Drug ATC Code Prediction Method Based on Graph Transformer Network for Drug Discovery. PMID:35721178
Bioinformatics and System Biology Approach to Reveal the Interaction Network and the Therapeutic Implications for Non-Small Cell Lung Cancer Patients With COVID-19. PMID:35721149
Diagnostic value of abnormal chromosome 3p genes in small-cell lung cancer. PMID:35720498
Network approaches for modeling the effect of drugs and diseases. PMID:35704883
Discrete modeling for integration and analysis of large-scale signaling networks. PMID:35696426
Pharmacological mechanisms of sodium-glucose co-transporter 2 inhibitors in heart failure with preserved ejection fraction. PMID:35689186
Exploring the Effect and Mechanism of Si-Miao-Yong-An Decoction on Abdominal Aortic Aneurysm Based on Mice Experiment and Bioinformatics Analysis. PMID:35685724
Investigation of the mechanism of Shen Qi Wan prescription in the treatment of T2DM via network pharmacology and molecular docking. PMID:35673584
Exploring the comorbidity mechanisms between asthma and idiopathic pulmonary fibrosis and the pharmacological mechanisms of Bu-Shen-Yi-Qi decoction therapy via network pharmacology. PMID:35672815
A Role for Gene-Environment Interactions in Autism Spectrum Disorder Is Supported by Variants in Genes Regulating the Effects of Exposure to Xenobiotics. PMID:35663546
Expediting knowledge acquisition by a web framework for Knowledge Graph Exploration and Visualization (KGEV): case studies on COVID-19 and Human Phenotype Ontology. PMID:35655307
Computational drug repositioning using similarity constrained weight regularization matrix factorization: A case of COVID-19. PMID:35644992
Identification of Ferroptosis-Related Hub Genes and Their Association with Immune Infiltration in Chronic Obstructive Pulmonary Disease by Bioinformatics Analysis. PMID:35637927
Analysis of multiple databases identifies crucial genes correlated with prognosis of hepatocellular carcinoma. PMID:35637248
Identification of the Key Genes and Potential Therapeutic Compounds for Abdominal Aortic Aneurysm Based on a Weighted Correlation Network Analysis. PMID:35625787
Immune-Related Protein Interaction Network in Severe COVID-19 Patients toward the Identification of Key Proteins and Drug Repurposing. PMID:35625619
Chemical Mixtures in Household Environments: In Silico Predictions and In Vitro Testing of Potential Joint Action on PPARγ in Human Liver Cells. PMID:35622613
Drug Repositioning with GraphSAGE and Clustering Constraints Based on Drug and Disease Networks. PMID:35620297
iUMRG: multi-layered network-guided propagation modeling for the inference of susceptibility genes and potential drugs against uveal melanoma. PMID:35610253
Hexokinase 2 is a transcriptional target and a positive modulator of AHR signalling. PMID:35609998
Molecular mechanism of ovarian toxicity of Hook.F. a study based on network pharmacology and molecular docking. PMID:35576115
A Community-Driven, Openly Accessible Molecular Pathway Integrating Knowledge on Malignant Pleural Mesothelioma. PMID:35558518
Mechanism of Jujube (Ziziphus jujuba Mill.) Fruit in the Appetite Regulation Based on Network Pharmacology and Molecular Docking Method. PMID:35480085
Theophylline: Old Drug in a New Light, Application in COVID-19 through Computational Studies. PMID:35456985
Network Pharmacology-Based Approach Combined with Bioinformatic Analytics to Elucidate the Potential of Curcumol against Hepatocellular Carcinoma. PMID:35456457
Network Pharmacologic Analysis of Dendrobium officinale Extract Inhibiting the Proliferation of Gastric Cancer Cells. PMID:35401206
Exploring the Potential Toxicological Mechanisms of Vine Tea on the Liver Based on Network Toxicology and Transcriptomics. PMID:35392562
Analysis of Gene-Environment Interactions Related to Developmental Disorders. PMID:35370658
The Shared Mechanism and Candidate Drugs of Multiple Sclerosis and Sjögren's Syndrome Analyzed by Bioinformatics Based on GWAS and Transcriptome Data. PMID:35356004
Assessing the effects of antipsychotic medications on schizophrenia functional analysis: a postmortem proteome study. PMID:35354897
Network Crosstalk as a Basis for Drug Repurposing. PMID:35350247
GPC2 Is a Potential Diagnostic, Immunological, and Prognostic Biomarker in Pan-Cancer. PMID:35345673
Functional Enrichment Analysis of Regulatory Elements. PMID:35327392
Exploring the Mechanism of Danshensu in the Treatment of Doxorubicin-Induced Cardiotoxicity Based on Network Pharmacology and Experimental Evaluation. PMID:35295262
From Causal Networks to Adverse Outcome Pathways: A Developmental Neurotoxicity Case Study. PMID:35295214
HAUS5 Is A Potential Prognostic Biomarker With Functional Significance in Breast Cancer. PMID:35280773
SAAED: Embedding and Deep Learning Enhance Accurate Prediction of Association Between circRNA and Disease. PMID:35273640
In silico drug repositioning based on integrated drug targets and canonical correlation analysis. PMID:35249529
PubChem Protein, Gene, Pathway, and Taxonomy Data Collections: Bridging Biology and Chemistry through Target-Centric Views of PubChem Data. PMID:35227770
HDL-Associated Lipoproteins: Potential Prognostic Biomarkers for Gram-Negative Sepsis. PMID:35210815
DOTA: Deep Learning Optimal Transport Approach to Advance Drug Repositioning for Alzheimer's Disease. PMID:35204697
Overexpression of CAPG Is Associated with Poor Prognosis and Immunosuppressive Cell Infiltration in Ovarian Cancer. PMID:35186171
Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity. PMID:35146398
Diosgenin From Dioscorea Nipponica Rhizoma Against Graves' Disease-On Network Pharmacology and Experimental Evaluation. PMID:35140607
EDTox: an R Shiny application to predict the endocrine disruption potential of compounds. PMID:35134136
DDIT: An Online Predictor for Multiple Clinical Phenotypic Drug-Disease Associations. PMID:35126114
A Data Mining Approach Reveals Chemicals Detected at Higher Levels in Non-Hispanic Black Women Target Preterm Birth Genes and Pathways. PMID:35107823
Ontology-based identification and prioritization of candidate drugs for epilepsy from literature. PMID:35073996
A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics Analysis. PMID:35069542
Effects of Isorhamnetin on Diabetes and Its Associated Complications: A Review of In Vitro and In Vivo Studies and a Post Hoc Transcriptome Analysis of Involved Molecular Pathways. PMID:35054888
DNA Microarray-Based Global Gene Expression Profiling in Human Amniotic Epithelial Cells Predicts the Potential of Microalgae-Derived Squalene for the Nervous System and Metabolic Health. PMID:35052729
Study on the Mechanism of Compound Kidney-Invigorating Granule for Osteoporosis based on Network Pharmacology and Experimental Verification. PMID:35027934
Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes. PMID:35010832
The evolution of knowledge on genes associated with human diseases. PMID:35005554
Comprehensive Analyses of the Expression, Genetic Alteration, Prognosis Significance, and Interaction Networks of m6A Regulators Across Human Cancers. PMID:35003212
A Deep-Learning Proteomic-Scale Approach for Drug Design. PMID:34959678
Single-Nucleotide Polymorphisms Promote Dysregulation Activation by Essential Gene Mediated Bio-Molecular Interaction in Breast Cancer. PMID:34926308
Identification of the Resveratrol Potential Targets in the Treatment of Osteoarthritis. PMID:34917160
Network Analysis of Microarray Data. PMID:34902128
Exploration of the mechanism of luteolin against ischemic stroke based on network pharmacology, molecular docking and experimental verification. PMID:34898370
Exploring the Antiglioma Mechanisms of Luteolin Based on Network Pharmacology and Experimental Verification. PMID:34873410
Antidepressant Mechanism of Traditional Chinese Medicine Formula Xiaoyaosan in CUMS-Induced Depressed Mouse Model via RIPK1-RIPK3-MLKL Mediated Necroptosis Based on Network Pharmacology Analysis. PMID:34867405
Screening of Important Factors in the Early Sepsis Stage Based on the Evaluation of ssGSEA Algorithm and ceRNA Regulatory Network. PMID:34866895
Comprehensive analysis of miRNA-mRNA regulatory network and potential drugs in chronic chagasic cardiomyopathy across human and mouse. PMID:34844599
Mapping Compound Databases to Disease Maps-A MINERVA Plugin for CandActBase. PMID:34834423
Integrating Network Pharmacology, Transcriptome and Artificial Intelligence for Investigating Into the Effect and Mechanism of Ning Fei Ping Xue Decoction Against the Acute Respiratory Distress Syndrome. PMID:34803679
BrainBase: a curated knowledgebase for brain diseases. PMID:34718720
Integrating heterogeneous data to facilitate COVID-19 drug repurposing. PMID:34666181
Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants. PMID:34636724
Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway. PMID:34616521
Comprehensive Survey of Recent Drug Discovery Using Deep Learning. PMID:34576146
Network pharmacology study on the mechanism of Qiangzhifang in the treatment of panic disorder. PMID:34532487
Identification of Novel Gene Signatures using Next-Generation Sequencing Data from COVID-19 Infection Models: Focus on Neuro-COVID and Potential Therapeutics. PMID:34531741
Arsenic exposure and human blood DNA methylation and hydroxymethylation profiles in two diverse populations from Bangladesh and Spain. PMID:34516978
Identification of the similarly expressed genes in patients with polycystic ovary syndrome and transsexuals. PMID:34477128
Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using the Comparative Toxicogenomics Database. PMID:34458863
Biomolecule and Bioentity Interaction Databases in Systems Biology: A Comprehensive Review. PMID:34439912
Computational Approaches for Cancer-Fighting: From Gene Expression to Functional Foods. PMID:34439361
NCAPG promotes the progression of lung adenocarcinoma via the TGF-β signaling pathway. PMID:34419073
Exploring Chemical Information in PubChem. PMID:34370395
PlasmiR: A Manual Collection of Circulating microRNAs of Prognostic and Diagnostic Value. PMID:34359584
Regulatory Status of Pesticide Residues in Cannabis: Implications to Medical Use in Neurological Diseases. PMID:34308371
Polychlorinated biphenyls induce oxidative stress and metabolic responses in astrocytes. PMID:34265337
Design, Synthesis, Biological Evaluation and Silico Prediction of Novel Sinomenine Derivatives. PMID:34200341
LUNAR :Drug Screening for Novel Coronavirus Based on Representation Learning Graph Convolutional Network. PMID:34081583
Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation. PMID:34054546
Perinatal DEHP exposure induces sex- and tissue-specific DNA methylation changes in both juvenile and adult mice. PMID:33986952
Exposure to sevoflurane results in changes of transcription factor occupancy in sperm and inheritance of autism†. PMID:33982067
Deciphering Pharmacological Mechanism of Buyang Huanwu Decoction for Spinal Cord Injury by Network Pharmacology Approach. PMID:33976706
The comprehensive landscape of miR-34a in cancer research. PMID:33959850
A Network Medicine Approach for Drug Repurposing in Duchenne Muscular Dystrophy. PMID:33918694
Exploring the Pharmacological Mechanism of Duhuo Jisheng Decoction in Treating Osteoporosis Based on Network Pharmacology. PMID:33880122
Traditional Chinese Formula Xiaoyaosan Alleviates Depressive-Like Behavior in CUMS Mice by Regulating PEBP1-GPX4-Mediated Ferroptosis in the Hippocampus. PMID:33854318
Transcriptome-Wide Prediction and Measurement of Combined Effects Induced by Chemical Mixture Exposure in Zebrafish Embryos. PMID:33826412
Quantitative Proteomic Approach Reveals Altered Metabolic Pathways in Response to the Inhibition of Lysine Deacetylases in A549 Cells under Normoxia and Hypoxia. PMID:33806075
Discovery of New Protein Targets of BPA Analogs and Derivatives Associated with Noncommunicable Diseases: A Virtual High-Throughput Screening. PMID:33769846
CTD Anatomy: analyzing chemical-induced phenotypes and exposures from an anatomical perspective, with implications for environmental health studies. PMID:33768211
A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence. PMID:33666848
In silico drug repositioning based on the integration of chemical, genomic and pharmacological spaces. PMID:33557749