Pharmacogenomics Knowledge Base
Names
More detailed information about this field from each metasource.
Pharmacogenomics Knowledge Base
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
PharmGKB
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:43.873620
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
Pharmacogenomics Knowledgebase
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
pharmgkb
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:43.873620
Names
More detailed information about this field from each metasource.
Pharmacogenomics Knowledge Base
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
PharmGKB
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:43.873620
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
Pharmacogenomics Knowledgebase
metasource: re3data.orgversion: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
pharmgkb
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:30:43.873620
Other names: PharmGKB, Pharmacogenomics Knowledgebase, pharmgkb
Names
More detailed information about this field from each metasource.
Pharmacogenomics Knowledge Base
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
PharmGKB
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:43.873620
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
Pharmacogenomics Knowledgebase
metasource: re3data.orgversion: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
pharmgkb
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:30:43.873620
PharmGKB is a resource that provides information about how human genetic variation affects response to medications. PharmGKB collects, curates and disseminates knowledge about clinically actionable gene-drug associations and genotype-phenotype relationships.
Description
More detailed information about this field from each metasource.
PharmGKB is a resource that provides information about how human genetic variation affects response to medications. PharmGKB collects, curates and disseminates knowledge about clinically actionable gene-drug associations and genotype-phenotype relationships.
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
PharmGKB curates primary genotype and phenotype data, annotates gene variants and gene-drug-disease relationships via literature review, and summarizes important PGx genes and drug pathways. PharmGKB collects, curates and disseminates knowledge about the impact of human genetic variation on drug responses.
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
The Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB; http://www.pharmgkb.org/) is a public resource that promotes research into the relationships between human genotypes, phenotypes, and clinical outcomes by linking and annotating primary datasets from ongoing research and established data from the literature. In addition to gene-drug relationships, the PharmGKB also contains data on gene variation, genomics, gene-disease relationships, drug action, and pathways. The PharmGKB has developed highly curated pathways documenting the genes involved in pharmacodynamics and pharmacokinetics of aselection of drugs and aims to enrich these by exchange with other metabolic and signaling pathway resources using BioPAX exchange format. We developed an XML format for defining genotype data, a relational database schema for data storage, and a flexible mechanism for submitting phenotype data. We are participating in the PML effort to define an XML standard for genotype/phenotype data exchange. Finally, we created a community project that encourages the research community to submit pharmacogenomic knowledge from the literature. PharmGKB first came online in April 2000. Access is free but requires users to register for a username and password for viewing individual subject data, in order to comply with HIPAA regulations. CATEGORIES OF EVIDENCE To establish a link between a genetic variation and variation in a phenotype, many different types of experiments can be performed, ranging from genotypic studies to cellular phenotype assays, to clinical studies. It is problematic to search a database with such diverse data types. We associate all experimental results with a category of evidence, which provides the context for its significance. We use five categories, and all data entering PharmGKB must be labeled with one of them. If a study shows a significant difference in a clinical outcome (death, disability, pain, days of work missed) based on a genetic difference, then the data falls under the Clinical Outcome category. The Pharmacodynamics and Drug Response category consists of studies that have shown a variation in a drug response that can be measured clinically, but is not a direct outcome. The Pharmacokinetics category quantifies how drug metabolism changes based on genetic changes, and Molecular and Cellular Functional Assays show associations between genetic changes and changes in functional assay results. Finally, the Genotype category contains data showing basic variability in gene sequences. We show the Category of Evidence for all data being displayed, as well as appropriate literature annotations and cross-references to external databases. We expect that researchers will direct their hypotheses into those areas where data is sparse. PHENOTYPE DATA While much work has been done to create an XML and associated database schema for describing information about genetic variation, the PharmGKB is also focused on collecting phenotypic data associated with genetic variation. There are inherent difficulties of attempting to create a database schema for phenotypic data because of the vast range of clinical studies, each with specialized methods of reporting results. Therefore, PharmGKB initially took a library approach to accepting phenotypic data. We accept annotated spreadsheet data from researchers, who also provide us with the Category of Evidence of the data, the gene-drug relationships, and keywords for finding the data. We store and index the data in the database and link to related research information. We present a unified view with the Categories of Evidence, such that users can easily access all information related to a drug-gene relationship. Users searching our site can then view and download phenotype data. We are actively engaged in the PML effort (2) to create a standard for the definition, storage, and exchange of phenotype data via XML. DATABASE UPGRADES Qualitative analysis of our system has shown that having a frame-based data storage facility suffered in retrieval performance. While the use of a frame-base system provided a flexible means for early data modeling, a database backend has shown better performance in storing and retrieving information. (3) Data is now stored centrally in a relational database. 4) We are beginning to accept large, high-throughput datasets, including whole-genome analyses, and are preparing to meet the challenges of future datasets in the multi-gigabyte-to-terabyte range.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
PharmGKB is a comprehensive resource that curates knowledge about the impact of genetic variation on drug response for clinicians and researchers. PharmGKB brings together the relevant data in a single place and adds value by combining disparate data on the same relationship, making it easier to search and easier to view the key aspects and by interpreting the data.PharmGKB provide clinical interpretations of this data, curated pathways and VIP summaries which are not found elsewhere.
metasource: re3data.orgversion: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
Database on the impact of human genetic variations on drug response. PharmGKB curates primary genotype and phenotype data, annotate gene variants and gene-drug-disease relationships via literature review, and summarize important PGx genes and drug pathways.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:30:43.873620
Webpage:
www.pharmgkb.orgWebpage
More detailed information about this field from each metasource.
www.pharmgkb.org
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
https://www.pharmgkb.org/
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
http://www.pharmgkb.org/
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
http://www.pharmgkb.org
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:30:43.873620
Licence:
Name: Creative Commons Attribution-ShareAlike v4.0Licence name
More detailed information about this field from each metasource.
Creative Commons Attribution-ShareAlike v4.0
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
CC
metasource: re3data.orgversion: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
CC-BY-NC-SA-4.0
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:30:43.873620
Licence URL
More detailed information about this field from each metasource.
https://www.pharmgkb.org/page/dataUsagePolicy
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
https://creativecommons.org/licenses/by-sa/4.0/
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
Publications:
Publications
More detailed information about this field from each metasource.
Pharmacogenomics knowledge for personalized medicine
PMID: 22992668
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:43.873620
Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base
PMID: 11908751
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
Publications
More detailed information about this field from each metasource.
Pharmacogenomics knowledge for personalized medicine
PMID: 22992668
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:43.873620
Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base
PMID: 11908751
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
-
Pharmacogenomics knowledge for personalized medicine
PubMed citations: 701.
701 articles citing: Pharmacogenomics knowledge for personalized medicine
Patterns of Convergence and Divergence Between Bipolar Disorder Type I and Type II: Evidence From Integrative Genomic Analyses. PMID:35912095
Case report: Non-response to fluoxetine in a homozygous 5-HTTLPR S-allele carrier of the serotonin transporter gene. PMID:35911243
A Guide to a Pharmacist-Led Pharmacogenetic Testing and Counselling Service in an Interprofessional Healthcare Setting. PMID:35893724
The heterogeneous pharmacological medical biochemical network PharMeBINet. PMID:35821017
Richtlinie der Gendiagnostik-Kommission (GEKO) für die Beurteilung genetischer Eigenschaften hinsichtlich ihrer Bedeutung für die Wirkung eines Arzneimittels bei einer Behandlung gemäß § 23 Abs. 2 Nr. 1b GenDG : revidierte Fassung vom 29.04.2022, veröffentlicht und in Kraft getreten am 03.06.2022, ersetzt die Fassung vom 25.11.2016. PMID:35776150
The frequency of major CYP2C19 genetic polymorphisms in women of Asian, Native Hawaiian and Pacific Islander subgroups. PMID:35748236
Breast cancer in the era of precision medicine. PMID:35733061
Investigation of target sequencing of SARS-CoV-2 and immunogenic GWAS profiling in host cells of COVID-19 in Vietnam. PMID:35718768
Text Mining Protocol to Retrieve Significant Drug-Gene Interactions from PubMed Abstracts. PMID:35713857
A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19. PMID:35677070
Network pharmacology and in vivo experiments reveal the pharmacological effects and molecular mechanisms of Simiao Powder in prevention and treatment for gout. PMID:35672755
Clinical Implementation of DPYD Pharmacogenetic Testing to Prevent Early-Onset Fluoropyrimidine-Related Toxicity in Cancer Patients in Switzerland. PMID:35662713
Genetic changes associated with relapse in favorable histology Wilms tumor: A Children's Oncology Group AREN03B2 study. PMID:35617957
OncoboxPD: human 51 672 molecular pathways database with tools for activity calculating and visualization. PMID:35615022
Exploration of the System-Level Mechanisms of the Herbal Drug FDY003 for Pancreatic Cancer Treatment: A Network Pharmacological Investigation. PMID:35591866
Pharmacogenetics of thiopurines. PMID:35582727
Exploring near-infrared absorbing nanocarriers to overcome cancer drug resistance. PMID:35582453
Pharmacogenetics implementation in the clinics: information and guidelines for germline variants. PMID:35582138
A Data Science Approach for the Identification of Molecular Signatures of Aggressive Cancers. PMID:35565454
Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial. PMID:35543701
Pharmacogenetic distinction of the Croatian population from the European average. PMID:35505645
The Prevalence of Pharmacogenomics Variants and Their Clinical Relevance Among the Pakistani Population. PMID:35497687
Bioinformatic Challenges Detecting Genetic Variation in Precision Medicine Programs. PMID:35463004
Impact of the Genotype and Phenotype of CYP3A and P-gp on the Apixaban and Rivaroxaban Exposure in a Real-World Setting. PMID:35455642
A Study on Methodologies of Drug Repositioning Using Biomedical Big Data: A Focus on Diabetes Mellitus. PMID:35413782
Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders. PMID:35393395
From pharmacogenetics to pharmaco-omics: Milestones and future directions. PMID:35373152
Opportunities for personalizing colorectal cancer care: an analysis of SEER-medicare data. PMID:35361994
Role of Pharmacogenetics in the Treatment of Acute Myeloid Leukemia: Systematic Review and Future Perspectives. PMID:35335935
Physiologically Based Pharmacokinetic Modelling and Simulation to Predict the Plasma Concentration Profile of Doxorubicin. PMID:35335919
A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity. PMID:35307978
Genetic Epidemiology of Medication Safety and Efficacy Related Variants in the Central Han Chinese Population With Whole Genome Sequencing. PMID:35280256
Warfarin dosing strategies evolution and its progress in the era of precision medicine, a narrative review. PMID:35247148
DeSIDE-DDI: interpretable prediction of drug-drug interactions using drug-induced gene expressions. PMID:35246258
Computational Resources for the Interpretation of Variations in Cancer. PMID:35230689
Comparison of FDA Table of Pharmacogenetic Associations and Clinical Pharmacogenetics Implementation Consortium guidelines. PMID:35230418
PubChem Protein, Gene, Pathway, and Taxonomy Data Collections: Bridging Biology and Chemistry through Target-Centric Views of PubChem Data. PMID:35227770
African Genomic Medicine Portal: A Web Portal for Biomedical Applications. PMID:35207753
Pharmacogenetics of Drugs Used in the Treatment of Cancers. PMID:35205356
The Effect of Hepatic Impairment on the Pharmacokinetics of Dacomitinib. PMID:35195881
Life-Threatening Docetaxel Toxicity in a Patient With Reduced-Function CYP3A Variants: A Case Report. PMID:35174070
A population study of clinically actionable genetic variation affecting drug response from the Middle East. PMID:35169154
Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids. PMID:35163210
Contribution of common and rare genetic variants in CEP72 on vincristine-induced peripheral neuropathy in brain tumour patients. PMID:35150001
Genetic Factors Associated With Tardive Dyskinesia: From Pre-clinical Models to Clinical Studies. PMID:35140610
A Preliminary Inquiry Into the Potential Mechanism of Huang-Lian-Jie-Du Decoction in Treating Rheumatoid Arthritis via Network Pharmacology and Molecular Docking. PMID:35127697
Tamoxifen side effects: pharmacogenetic and clinical approach in Mexican mestizos. PMID:35116730
Evaluation of the EMPAR study population on the basis of metabolic phenotypes of selected pharmacogenes. PMID:35102241
Keeping pace with CYP2D6 haplotype discovery: innovative methods to assign function. PMID:35083931
Reducing severe cutaneous adverse and type B adverse drug reactions using pre-stored human leukocyte antigen genotypes. PMID:35070271
Identification of putative genetic variants in major depressive disorder patients in Pakistan. PMID:35040003
Plant Reactome and PubChem: The Plant Pathway and (Bio)Chemical Entity Knowledgebases. PMID:35037224
NETME: on-the-fly knowledge network construction from biomedical literature. PMID:35013714
A Systematic Review and Recommendations Around Frameworks for Evaluating Scientific Validity in Nutritional Genomics. PMID:35004815
Transcriptome-Wide Analysis of Human Liver Reveals Age-Related Differences in the Expression of Select Functional Gene Clusters and Evidence for a PPP1R10-Governed 'Aging Cascade'. PMID:34959291
Loss of microRNA-135b Enhances Bone Metastasis in Prostate Cancer and Predicts Aggressiveness in Human Prostate Samples. PMID:34944822
PAGEANT: personal access to genome and analysis of natural traits. PMID:34928375
Identifying cancer pathway dysregulations using differential causal effects. PMID:34927666
Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses. PMID:34918496
Pharmacist-guided pre-emptive pharmacogenetic testing in antidepressant therapy (PrePGx): study protocol for an open-label, randomized controlled trial. PMID:34906208
Analysis of CYP2C19 genetic variants with ischaemic events in UK patients prescribed clopidogrel in primary care: a retrospective cohort study. PMID:34903548
Preliminary Pharmacogenomic-Based Predictive Models of Tamoxifen Response in Hormone-dependent Chilean Breast Cancer Patients. PMID:34899282
An Investigation of the Knowledge Overlap between Pharmacogenomics and Disease Genetics. PMID:34890165
The Secretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-Induced Cytotoxicity: Impact in Non-Tumor Cells. PMID:34884877
The Pharmacological Mechanism of Guchangzhixie Capsule Against Experimental Colitis. PMID:34867387
A Novel Mutation of the KLK6 Gene in a Family With Knee Osteoarthritis. PMID:34858488
ConsensusPathDB 2022: molecular interactions update as a resource for network biology. PMID:34850110
Classification of Companion Diagnostics: A New Framework for Biomarker-Driven Patient Selection. PMID:34841493
PharmVIP: A Web-Based Tool for Pharmacogenomic Variant Analysis and Interpretation. PMID:34834582
Genetic diversity of 'Very Important Pharmacogenes' in two South-Asian populations. PMID:34824904
Pharmacogenomic analysis of a genetically distinct Indigenous population. PMID:34824386
Consensus of experts from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology for the genotyping of DPYD in cancer patients who are candidates for treatment with fluoropyrimidines. PMID:34773566
Development and Implementation of In-House Pharmacogenomic Testing Program at a Major Academic Health System. PMID:34745204
Experience of a Strategy Including CYP2C19 Preemptive Genotyping Followed by Therapeutic Drug Monitoring of Voriconazole in Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation. PMID:34744712
'Omics' of suicidal behaviour: A path to personalised psychiatry. PMID:34733641
Path4Drug: Data Science Workflow for Identification of Tissue-Specific Biological Pathways Modulated by Toxic Drugs. PMID:34721010
The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations. PMID:34721006
Effects of Cytochrome P450 and Transporter Polymorphisms on the Bioavailability and Safety of Dutasteride and Tamsulosin. PMID:34690761
Common UGT1A9 polymorphisms do not have a clinically meaningful impact on the apparent oral clearance of dapagliflozin in type 2 diabetes mellitus. PMID:34687551
Influence of CYP2D6 metabolizer status on ondansetron efficacy in pediatric patients undergoing hematopoietic stem cell transplantation: A case series. PMID:34670017
Clinical Implications of Combinatorial Pharmacogenomic Tests Based on Cytochrome P450 Variant Selection. PMID:34650593
In vivo study of light-driven naproxen release from gated mesoporous silica drug delivery system. PMID:34642409
Association of TLR 9 gene polymorphisms with remission in patients with rheumatoid arthritis receiving TNF-α inhibitors and development of machine learning models. PMID:34635730
The need to shift pharmacogenetic research from candidate gene to genome-wide association studies. PMID:34608812
Cross-Disorder Genomics Data Analysis Elucidates a Shared Genetic Basis Between Major Depression and Osteoarthritis Pain. PMID:34603368
Pharmacogenetic testing for adverse drug reaction prevention: systematic review of economic evaluations and the appraisal of quality matters for clinical practice and implementation. PMID:34600523
Clinical implementation of drug metabolizing gene-based therapeutic interventions worldwide. PMID:34599365
Pharmacogenetics in Neuroblastoma: What Can Already Be Clinically Implemented and What Is Coming Next? PMID:34575974
Treatment Response to SGLT2 Inhibitors: From Clinical Characteristics to Genetic Variations. PMID:34575958
Effect of Genetic Variation in CYP450 on Gonadal Impairment in a European Cohort of Female Childhood Cancer Survivors, Based on a Candidate Gene Approach: Results from the PanCareLIFE Study. PMID:34572825
Pharmacogenetics in Pharmaceutical Care-Piloting an Application-Oriented Blended Learning Concept. PMID:34564559
Retrospective pharmacogenetic analysis of a pediatric patient under anticoagulant treatment: Clinical case. PMID:34559488
Label-Free Identification of Single Mononucleotides by Nanoscale Electrophoresis. PMID:34558175
Chemotherapy, targeted therapy and immunotherapy: Which drugs can be safely used in the solid organ transplant recipients? PMID:34555228
A Review of CYP3A Drug-Drug Interaction Studies: Practical Guidelines for Patients Using Targeted Oral Anticancer Drugs. PMID:34526892
A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict clinically relevant toxicity associated with fluoropyrimidine and platinum-based chemotherapy in gastric cancer. PMID:34525956
Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics Approaches. PMID:34519533
CYP450 Genotype-Phenotype Concordance Using the Geneva Micrococktail in a Clinical Setting. PMID:34512355
Multi-omic strategies applied to the study of pharmacoresistance in mesial temporal lobe epilepsy. PMID:34486831
Extracting Concepts for Precision Oncology from the Biomedical Literature. PMID:34457142
Gene Polymorphisms of the Renin-Angiotensin System and Bleeding Complications of Warfarin: Genetic-Based Machine Learning Models. PMID:34451921
Quercetin and/or Ascorbic Acid Modulatory Effect on Phenobarbital-Induced Sleeping Mice Possibly through GABAA and GABAB Receptor Interaction Pathway. PMID:34451819
Drug Discovery of Spinal Muscular Atrophy (SMA) from the Computational Perspective: A Comprehensive Review. PMID:34445667
Sex-Biased Expression of Pharmacogenes across Human Tissues. PMID:34439872
High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs. PMID:34437536
Herb-Drug Interactions: Worlds Intersect with the Patient at the Center. PMID:34436223
Fast mutual exclusivity algorithm nominates potential synthetic lethal gene pairs through brute force matrix product computations. PMID:34429855
Nardosinone Alleviates Parkinson's Disease Symptoms in Mice by Regulating Dopamine D2 Receptor. PMID:34426745
Identification of Potential Bioactive Ingredients and Mechanisms of the Guanxin Suhe Pill on Angina Pectoris by Integrating Network Pharmacology and Molecular Docking. PMID:34422068
Comparison of clinical pharmacogenetic recommendations across therapeutic areas. PMID:34412102
Vitamin K antagonist anticoagulant usage is associated with increased incidence and progression of osteoarthritis. PMID:34412027
Ten simple rules for creating reusable pathway models for computational analysis and visualization. PMID:34411100
Perception of personalized medicine, pharmacogenomics, and genetic testing among undergraduates in Hong Kong. PMID:34407885
Co-delivery systems: hope for clinical application? PMID:34402023
PharmGKB, an Integrated Resource of Pharmacogenomic Knowledge. PMID:34387941
Measuring and interpreting pervasive heterogeneity, poikilosis. PMID:34377957
Appraisal and development of evidence-based clinical decision support to enable perioperative pharmacogenomic application. PMID:34376788
Clinical Relevance of a 16-Gene Pharmacogenetic Panel Test for Medication Management in a Cohort of 135 Patients. PMID:34361984
Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis. PMID:34349502
Pharmacogenomics in cancer supportive care: key issues and future directions. PMID:34333715
The application of cytokeratin-18 as a biomarker for drug-induced liver injury. PMID:34322741
Efficacy of computational predictions of the functional effect of idiosyncratic pharmacogenetic variants. PMID:34316407
Mapping the miRNA-mRNA Interactome in Human Hepatocytes and Identification of Functional mirSNPs in Pharmacogenes. PMID:34314509
MUSTARD-a comprehensive resource of mutation-specific therapies in cancer. PMID:34309639
A Combined Network Pharmacology and Molecular Docking Approach to Investigate Candidate Active Components and Multitarget Mechanisms of Hemerocallis Flowers on Antidepressant Effect. PMID:34306154
Insights into the molecular mechanisms of Huangqi decoction on liver fibrosis via computational systems pharmacology approaches. PMID:34301291
DysPIA: A Novel Dysregulated Pathway Identification Analysis Method. PMID:34290733
Experimental and Genomic Evaluation of the Oestrogen Degrading Bacterium Rhodococcus equi ATCC13557. PMID:34276604
Computational strategies for the discovery of biological functions of health foods, nutraceuticals and cosmeceuticals: a review. PMID:34258685
Optimizing prediction of response to antidepressant medications using machine learning and integrated genetic, clinical, and demographic data. PMID:34238923
Interest of Fluvoxamine as an Add-On to Clozapine in Children With Severe Psychiatric Disorder According to CYP Polymorphisms: Experience From a Case Series. PMID:34234701
Translational Pharmacogenomics: Discovery, Evidence Synthesis and Delivery of Race-Conscious Medicine. PMID:34233023
How to Integrate CYP2D6 Phenoconversion Into Clinical Pharmacogenetics: A Tutorial. PMID:34231197
Vaccines are not one size fits all, just like medications: rotavirus vaccine study. PMID:34222127
Admixture Has Shaped Romani Genetic Diversity in Clinically Relevant Variants. PMID:34220960
An Evidence-Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine. PMID:34216021
The Functionality of UDP-Glucuronosyltransferase Genetic Variants and their Association with Drug Responses and Human Diseases. PMID:34198586
Genomewide Association Studies in Pharmacogenomics. PMID:34185318
Trop-2 protein as a therapeutic target: A focused review on Trop-2-based antibody-drug conjugates and their predictive biomarkers. PMID:34181512
A comparison of genotyping arrays. PMID:34140649
Network Pharmacology-Based Validation of the Efficacy of Huiyangjiuji Decoction in the Treatment of Experimental Colitis. PMID:34122086
netgsa: Fast computation and interactive visualization for topology-based pathway enrichment analysis. PMID:34115744
PharmVar GeneFocus: CYP2C9. PMID:34109627
Pharmacogenomic considerations for repurposing of dexamethasone as a potential drug against SARS-CoV-2 infection. PMID:34086487
A pharmacophore-based classification better predicts the outcomes of HER2-negative breast cancer patients receiving the anthracycline- and/or taxane-based neoadjuvant chemotherapy. PMID:34076352
Psychoactive Medication, Violence, and Variant Alleles for Cytochrome P450 Genes. PMID:34069803
Drug Safety in Translational Paediatric Research: Practical Points to Consider for Paediatric Safety Profiling and Protocol Development: A Scoping Review. PMID:34064872
Implementation of Pharmacogenomics and Artificial Intelligence Tools for Chronic Disease Management in Primary Care Setting. PMID:34063850
The Role of Electronic Health Records in Advancing Genomic Medicine. PMID:34038146
Challenges in the Treatment of Restless Legs Syndrome: A Case Report. PMID:34032164
Pharmacogenomics (PGx) Patient with Mixed Levels of Actionable Variant Evidence. PMID:34007616
Additional Utility of Pharmacogenomics (PGx) Panel Testing in a CYP2D6 Normal Metabolizer with a History of Breast Cancer. PMID:34007571
Extracellular Vesicles: A Novel Tool Facilitating Personalized Medicine and Pharmacogenomics in Oncology. PMID:33995103
CYP2E1, GSTM1, and GSTT1 genetic polymorphisms and their associations with susceptibility to antituberculosis drug-induced liver injury in Thai tuberculosis patients. PMID:33981901
A New Insight for the Identification of Oncogenic Variants in Breast and Prostate Cancers in Diverse Human Populations, With a Focus on Latinos. PMID:33912047
Network Pharmacology Analysis of ZiShenWan for Diabetic Nephropathy and Experimental Verification of Its Anti-Inflammatory Mechanism. PMID:33883881
Clinical pharmacogenomics in action: design, assessment and implementation of a novel pharmacogenetic panel supporting drug selection for diseases of the central nervous system (CNS). PMID:33858454
Identifying genetic modulators of statin response using subject-derived lymphoblastoid cell lines. PMID:33858191
Evaluation of serious bleeding signals during concomitant use of clopidogrel and hypnotic drugs. PMID:33845372
A review on compound-protein interaction prediction methods: Data, format, representation and model. PMID:33841755
Generalized exfoliative skin rash as an early predictor of supratherapeutic voriconazole trough levels in a leukemic child: A case report. PMID:33834148
Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights. PMID:33831079
Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins. PMID:33820928
Sequence2Script: A Web-Based Tool for Translation of Pharmacogenetic Data Into Evidence-Based Prescribing Recommendations. PMID:33815120
Meta-Analysis of Noncompartmental Pharmacokinetic Parameters of Ertugliflozin to Evaluate Dose Proportionality and UGT1A9 Polymorphism Effect on Exposure. PMID:33813736
Pharmacogenomic Biomarkers in US FDA-Approved Drug Labels (2000-2020). PMID:33806453
Metabolic N-Dealkylation and N-Oxidation as Elucidators of the Role of Alkylamino Moieties in Drugs Acting at Various Receptors. PMID:33805491
UGT1A1 Guided Cancer Therapy: Review of the Evidence and Considerations for Clinical Implementation. PMID:33805415
Opportunities and challenges for the computational interpretation of rare variation in clinically important genes. PMID:33798442
Description of the genetic variants identified in a cohort of patients diagnosed with localized anal squamous cell carcinoma and treated with panitumumab. PMID:33795829
Novel risk factors for glucarpidase use in pediatric acute lymphoblastic leukemia: Hispanic ethnicity, age, and the ABCC4 gene. PMID:33788417
The Implementation Science for Genomic Health Translation (INSIGHT) Study in Epilepsy: Protocol for a Learning Health Care System. PMID:33769305
Potential Impact of DPYD Variation on Fluoropyrimidine Drug Response in sub-Saharan African Populations. PMID:33767731
Network Pharmacology and Pharmacological Evaluation Reveals the Mechanism of the Sanguisorba Officinalis in Suppressing Hepatocellular Carcinoma. PMID:33746755
NOGEA: A Network-oriented Gene Entropy Approach for Dissecting Disease Comorbidity and Drug Repositioning. PMID:33744433
A retrospective analysis of actionable pharmacogenetic/genomic biomarker language in FDA labels. PMID:33742770
Identification of disease treatment mechanisms through the multiscale interactome. PMID:33741907
Search and visualization of gene-drug-disease interactions for pharmacogenomics and precision medicine research using GeneDive. PMID:33737208
Post-tuberculous lung disease: should we be using Theophylline? PMID:33717595
Drug Response Pharmacogenetics for 200,000 UK Biobank Participants. PMID:33691016
Patient-Specific Network for Personalized Breast Cancer Therapy with Multi-Omics Data. PMID:33670375
TET2 mutations in acute myeloid leukemia: a comprehensive study in patients of Sindh, Pakistan. PMID:33643703
Identification of CYP2D6 Haplotypes that Interfere with Commonly Used Assays for Copy Number Variation Characterization. PMID:33631352
Mechanism of Modified Danggui Sini Decoction for Knee Osteoarthritis Based on Network Pharmacology and Molecular Docking. PMID:33628311
Uncovering the Anti-Lung-Cancer Mechanisms of the Herbal Drug FDY2004 by Network Pharmacology. PMID:33628308
A Network Pharmacology Study on the Molecular Mechanisms of FDY003 for Breast Cancer Treatment. PMID:33628298
BioDWH2: an automated graph-based data warehouse and mapping tool. PMID:33618440
Public data sources to support systems toxicology applications. PMID:33604492
Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease. PMID:33569077
Pharmacogenetics in developing countries and low resource environments. PMID:33564904
Association of CYP3A5 Gene Polymorphisms and Amlodipine-Induced Peripheral Edema in Chinese Han Patients with Essential Hypertension. PMID:33564260
Current and prospective computational approaches and challenges for developing COVID-19 vaccines. PMID:33561453
Pharmacogenomics of the Efficacy and Safety of Colchicine in COLCOT. PMID:33560138
SAveRUNNER: A network-based algorithm for drug repurposing and its application to COVID-19. PMID:33544720
Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs. PMID:33542445
Pharmacogenomics of Allopurinol and Sulfamethoxazole/Trimethoprim: Case Series and Review of the Literature. PMID:33530463
Harnessing machine learning for development of microbiome therapeutics. PMID:33522391
Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon. PMID:33519226
[Pregnancy-preserving and maternal-fetal management in a patient with rare large cell neuroendocrine carcinoma of the uterine cervix]. PMID:33509747
Prevalence of CYP2C19 polymorphism in Bogotá, Colombia: The first report of allele *17. PMID:33503046
Cyrius: accurate CYP2D6 genotyping using whole-genome sequencing data. PMID:33462347
MLIP genotype as a predictor of pharmacological response in primary open-angle glaucoma and ocular hypertension. PMID:33452295
PharmVar GeneFocus: CYP2B6. PMID:33448339
Pharmacogenetics of Direct Oral Anticoagulants: A Systematic Review. PMID:33440670
Longitudinal saliva omics responses to immune perturbation: a case study. PMID:33436912
Patients dispensed medications with actionable pharmacogenomic biomarkers: rates and characteristics. PMID:33420348
Exploring gene knockout strategies to identify potential drug targets using genome-scale metabolic models. PMID:33420254
Exploring pharmacogenetics of paclitaxel- and docetaxel-induced peripheral neuropathy by evaluating the direct pharmacogenetic-pharmacokinetic and pharmacokinetic-neuropathy relationships. PMID:33401943
Pharmacogenomics, How to Deal with Different Types of Variants in Next Generation Sequencing Data in the Personalized Medicine Area. PMID:33374421
An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak-Gamcho Decoction: A Network Pharmacology Study. PMID:33343676
Characterizing Pharmacogenetic Testing Among Children's Hospitals. PMID:33325650
A semantic relationship mining method among disorders, genes, and drugs from different biomedical datasets. PMID:33317518
multiGSEA: a GSEA-based pathway enrichment analysis for multi-omics data. PMID:33287694
A review of the pharmacogenomics of buprenorphine for the treatment of opioid use disorder. PMID:33274315
Flype: Software for enabling personalized medicine. PMID:33270363
Pharmacogenetics at Scale: An Analysis of the UK Biobank. PMID:33237584
Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts. PMID:33237278
The Road so Far in Colorectal Cancer Pharmacogenomics: Are We Closer to Individualised Treatment? PMID:33228198
Genetic Variants Affecting Anti-VEGF Drug Response in Polypoidal Choroidal Vasculopathy Patients: A Systematic Review and Meta-Analysis. PMID:33198211
Pharmacogenetics of Statin-Induced Myotoxicity. PMID:33193687
Metabolism of Long-Acting Rilpivirine After Intramuscular Injection: HIV Prevention Trials Network Study 076 (HPTN 076). PMID:33191765
A Study on the Mechanism of Milkvetch Root in the Treatment of Diabetic Nephropathy Based on Network Pharmacology. PMID:33178322
Methotrexate Decreases Tenofovir Exposure in Antiretroviral-Suppressed Individuals Living With HIV. PMID:33177476
PubChem in 2021: new data content and improved web interfaces. PMID:33151290
Transfer learning enables prediction of CYP2D6 haplotype function. PMID:33137098
Establishing a Framework for the Clinical Translation of Germline Findings in Precision Oncology. PMID:33134827
Clinical pharmacology applications in clinical drug development and clinical care: A focus on Saudi Arabia. PMID:33132716
Linking Pharmacogenomic Information on Drug Safety and Efficacy with Ethnic Minority Populations. PMID:33113799
Insights into the mechanism of Arnebia euchroma on leukemia via network pharmacology approach. PMID:33109189
Using drug descriptions and molecular structures for drug-drug interaction extraction from literature. PMID:33098410
Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs. PMID:33086061
Projected Utility of Pharmacogenomic Testing Among Individuals Hospitalized With COVID-19: A Retrospective Multicenter Study in the United States. PMID:33085221
Plasma miRNA profiles associated with stable warfarin dosage in Chinese patients. PMID:33083118
Pharmacogenetic information in Swiss drug labels - a systematic analysis. PMID:33070160
Retrospective Review of Pharmacogenetic Testing at an Academic Children's Hospital. PMID:33048453
Herbal pair Huangqin-Baishao: mechanisms underlying inflammatory bowel disease by combined system pharmacology and cell experiment approach. PMID:32988394
DPYD and UGT1A1 Pharmacogenetic Testing in Patients with Gastrointestinal Malignancies: An Overview of the Evidence and Considerations for Clinical Implementation. PMID:32985005
PharmGKB Tutorial for Pharmacogenomics of Drugs Potentially Used in the Context of COVID-19. PMID:32978778
Development and Analytical Validation of a 29 Gene Clinical Pharmacogenetic Genotyping Panel: Multi-Ethnic Allele and Copy Number Variant Detection. PMID:32931151
iGMDR: Integrated Pharmacogenetic Resource Guide to Cancer Therapy and Research. PMID:32916316
Essentiality and Transcriptome-Enriched Pathway Scores Predict Drug-Combination Synergy. PMID:32906805
Analysis of Drug Metabolizing Gene Panel in Osteosarcoma Patients Identifies Association Between Variants in SULT1E1, CYP2B6 and CYP4F8 and Methotrexate Levels and Toxicities. PMID:32903464
Computational Methods and Software Tools for Functional Analysis of miRNA Data. PMID:32872205
Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450. PMID:32872162
QT prolongation with hydroxychloroquine and azithromycin for the treatment of COVID-19: The need for pharmacogenetic insights. PMID:32870576
Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic Leukemia. PMID:32848445
Network Pharmacology to Identify the Pharmacological Mechanisms of a Traditional Chinese Medicine Derived from Trachelospermum jasminoides in Patients with Rheumatoid Arthritis. PMID:32840241
Enhancing and Complementary Mechanisms of Synergistic Action of Acori Tatarinowii Rhizoma and Codonopsis Radix for Alzheimer's Disease Based on Systems Pharmacology. PMID:32802132
Optimising Seniors' Metabolism of Medications and Avoiding Adverse Drug Events Using Data on How Metabolism by Their P450 Enzymes Varies with Ancestry and Drug-Drug and Drug-Drug-Gene Interactions. PMID:32796505
Genomic Analysis of Localized High-Risk Prostate Cancer Circulating Tumor Cells at the Single-Cell Level. PMID:32784507
Neuroblastoma patient-derived cultures are enriched for a mesenchymal gene signature and reflect individual drug response. PMID:32777141
CYP2C19 genotype-guided antiplatelet therapy: promises and pitfalls. PMID:32723143
Design and Early Implementation Successes and Challenges of a Pharmacogenetics Consult Clinic. PMID:32708920
Integration of Genomic Medicine in Pathology Resident Training. PMID:32696061
Effects of ABCB1, UGT1A1, and UGT1A9 Genetic Polymorphisms on the Pharmacokinetics of Sitafloxacin Granules in Healthy Subjects. PMID:32687695
Engineering Microphysiological Immune System Responses on Chips. PMID:32673588
Collaborative, Multidisciplinary Evaluation of Cancer Variants Through Virtual Molecular Tumor Boards Informs Local Clinical Practices. PMID:32644817
Constructing knowledge graphs and their biomedical applications. PMID:32637040
Deciphering the underlying mechanism of Xianlinggubao capsule against osteoporosis by network pharmacology. PMID:32620113
The Gut Microbiota Impact Cancer Etiology through "Phase IV Metabolism" of Xenobiotics and Endobiotics. PMID:32611614
Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing. PMID:32607875
PharmVar GeneFocus: CYP2C19. PMID:32602114
Adverse Drug Reactions in the Emergency Department: Is There a Role for Pharmacogenomic Profiles at Risk?-Results from the ADRED Study. PMID:32527038
Rural Community Perceptions and Interests in Pharmacogenomics. PMID:32516951
Brazilian cohort and genes encoding for drug-metabolizing enzymes and drug transporters. PMID:32486903
An Analysis of the Anti-Neuropathic Effects of Qi She Pill Based on Network Pharmacology. PMID:32454869
Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders. PMID:32433254
An exploratory analysis on the influence of genetic variants on weight gain among etonogestrel contraceptive implant users. PMID:32407811
Post-transplantation Cyclophosphamide: From HLA-Haploidentical to Matched-Related and Matched-Unrelated Donor Blood and Marrow Transplantation. PMID:32373119
Effects of various genetic polymorphisms on thiopurine treatment-associated outcomes for Korean patients with Crohn's disease. PMID:32372428
DRUGPATH: The Drug Gene Pathway Meta-Database. PMID:32365960
Predicted efficacy of a pharmacogenetic passport for inflammatory bowel disease. PMID:32363635
The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals. PMID:32355288
Translating insights from neuropsychiatric genetics and genomics for precision psychiatry. PMID:32349784
Gene-Wise Burden of Coding Variants Correlates to Noncoding Pharmacogenetic Risk Variants. PMID:32349395
Role of Genetic Variations in the Hepatic Handling of Drugs. PMID:32326111
PDZ Domains as Drug Targets. PMID:32313833
Drug repositioning: computational approaches and research examples classified according to the evidence level. PMID:32309593
MTHFR and VDR Polymorphisms Improve the Prognostic Value of MYCN Status on Overall Survival in Neuroblastoma Patients. PMID:32295184
Supportive care medications coinciding with chemotherapy among children with hematologic malignancy. PMID:32264729
Analysis of the Deleterious Single-Nucleotide Polymorphisms Associated With Antidepressant Efficacy in Major Depressive Disorder. PMID:32256400
MaveQuest: a web resource for planning experimental tests of human variant effects. PMID:32251504
A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer. PMID:32246132
Integrated Informatics Analysis of Cancer-Related Variants. PMID:32228266
OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine. PMID:32210335
A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver. PMID:32181701
Primary Care Prescription Drug Use and Related Actionable Drug-Gene Interactions in the Danish Population. PMID:32166845
PHARMIP: An insilico method to predict genetics that underpin adverse drug reactions. PMID:32123669
A Review of Precision Oncology Knowledgebases for Determining the Clinical Actionability of Genetic Variants. PMID:32117976
Network Pharmacology-Based Investigation of the System-Level Molecular Mechanisms of the Hematopoietic Activity of Samul-Tang, a Traditional Korean Herbal Formula. PMID:32104198
Lack of Association of Generic Brittle Status with Genetics and Physiologic Measures in Patients with Epilepsy. PMID:32103380
Successful aging: insights from proteome analyses of healthy centenarians. PMID:32100723
CYP2D6 polymorphism and its impact on the clinical response to metoprolol: A systematic review and meta-analysis. PMID:32090368
Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products. PMID:32089733
Pharmacogenetic Testing Options Relevant to Psychiatry in Canada: Options de tests pharmacogénétiques pertinents en psychiatrie au Canada. PMID:32064906
A systems approach to infectious disease. PMID:32060427
Applying whole-genome sequencing in relation to phenotype and outcomes in siblings with cystic fibrosis. PMID:32014855
Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis. PMID:31976001
Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness. PMID:31971968
The Role of CYP450 Drug Metabolism in Precision Cardio-Oncology. PMID:31963461
Pharmacogenetics in Practice: Estimating the Clinical Actionability of Pharmacogenetic Testing in Perioperative and Ambulatory Settings. PMID:31961467
The Current Status of Genes and Genetic Testing in Emergency Medicine: A Narrative Review. PMID:31938779
PGxCorpus, a manually annotated corpus for pharmacogenomics. PMID:31896797
Translational Knowledge Discovery Between Drug Interactions and Pharmacogenetics. PMID:31863452
A network pharmacology approach to reveal the protective mechanism of Salvia miltiorrhiza-Dalbergia odorifera coupled-herbs on coronary heart disease. PMID:31852981
Common CYP2D6, CYP2C9, and CYP2C19 Gene Variants, Health Anxiety, and Neuroticism Are Not Associated With Self-Reported Antidepressant Side Effects. PMID:31850065
Evaluating the consistency of large-scale pharmacogenomic studies. PMID:31846027
Basic Concepts in Genetics and Pharmacogenomics for Pharmacists. PMID:31832012
ClinVAP: a reporting strategy from variants to therapeutic options. PMID:31830259
Drug screening approach combines epigenetic sensitization with immunochemotherapy in cancer. PMID:31829282
GliomaDB: A Web Server for Integrating Glioma Omics Data and Interactive Analysis. PMID:31811943
Hepatocyte gene expression and DNA methylation as ancestry-dependent mechanisms in African Americans. PMID:31798965
PGxMine: Text mining for curation of PharmGKB. PMID:31797632
Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses. PMID:31772606
Identifying Cancer genes by combining two-rounds RWR based on multiple biological data. PMID:31760937
PharmVar and the Landscape of Pharmacogenetic Resources. PMID:31758698
Clinical Utility of Pharmacogene Panel-Based Testing in Patients Undergoing Percutaneous Coronary Intervention. PMID:31758664
pathDIP 4: an extended pathway annotations and enrichment analysis resource for human, model organisms and domesticated species. PMID:31733064
Clinical relevance of the lnc-HNF1B-3:1 genetic polymorphisms in Western Chinese tuberculosis patients. PMID:31692082
'One DB to rule them all'-the RING: a Regulatory INteraction Graph combining TFs, genes/proteins, SNPs, diseases and drugs. PMID:31682269
Polypharmacy: a healthcare conundrum with a pharmacogenetic solution. PMID:31680605
Beyond drugs: the evolution of genes involved in human response to medications. PMID:31640517
The Three Ps: Psychiatry, Pharmacy, and Pharmacogenomics, a Brief Report From New Zealand. PMID:31616328
Repurposing of Diagnostic Whole Exome Sequencing Data of 1,583 Individuals for Clinical Pharmacogenetics. PMID:31594036
The influence of geometry and other fundamental challenges for bio-sensing with field effect transistors. PMID:31588960
A stepwise approach to implementing pharmacogenetic testing in the primary care setting. PMID:31588877
Statin therapy: does sex matter? PMID:31513091
CYP2C19 and STAT6 Variants Influence the Outcome of Proton Pump Inhibitor Therapy in Pediatric Eosinophilic Esophagitis. PMID:31490856
Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials. PMID:31480618
Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good. PMID:31455423
Bridging the Gaps in Personalized Medicine Value Assessment: A Review of the Need for Outcome Metrics across Stakeholders and Scientific Disciplines. PMID:31454805
Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing. PMID:31454087
Interaction of repaglinide with bovine serum albumin: Spectroscopic and molecular docking approaches. PMID:31452966
Global Text Mining and Development of Pharmacogenomic Knowledge Resource for Precision Medicine. PMID:31447668
Identification of key genes in osteosarcoma by meta‑analysis of gene expression microarray. PMID:31432118
Pharmacy students' attitudes and perceptions toward pharmacogenomics education. PMID:31415690
Pharmacogenomic considerations for medications in the perioperative setting. PMID:31411557
Effects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates: A Study With the Modified Cooperstown 5+1 Cocktail. PMID:31378969
A Review of Bioinformatics Tools to Understand Acetaminophen-Alcohol Interaction. PMID:31349598
Inconsistency in race and ethnic classification in pharmacogenetics studies and its potential clinical implications. PMID:31308725
Interactions between antidepressants, sleep aids and selected breast cancer therapy. PMID:31281608
Utilising network pharmacology to explore the underlying mechanism of Wumei Pill in treating pancreatic neoplasms. PMID:31272505
Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients. PMID:31244663
g-Nomic: a new pharmacogenetics interpretation software. PMID:31239753
Predicting (side) effects for patients with inflammatory bowel disease: The promise of pharmacogenetics. PMID:31210708
Calling Star Alleles With Stargazer in 28 Pharmacogenes With Whole Genome Sequences. PMID:31206625
Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy. PMID:31190750
Population study of thrombophilic markers and pharmacogenetic markers of warfarin prevalence in Bosnia and Herzegovina. PMID:31187948
Projected Prevalence of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among US Veterans Health Administration Pharmacy Users. PMID:31173123
Predicting and Understanding the Human Microbiome's Impact on Pharmacology. PMID:31171383
Identifying mutation-driven changes in gene functionality that lead to venous thromboembolism. PMID:31144782
Cases in Precision Medicine: The Role of Pharmacogenetics in Precision Prescribing. PMID:31108507
Characterization of a class III peroxidase from Artemisia annua: relevance to artemisinin metabolism and beyond. PMID:31093899
A phase II study of ENMD-2076 in advanced soft tissue sarcoma (STS). PMID:31089155
Polymorphisms of ADME-related genes and their implications for drug safety and efficacy in Amazonian Amerindians. PMID:31076604
Recommendations for Clinical CYP2C9 Genotyping Allele Selection: A Joint Recommendation of the Association for Molecular Pathology and College of American Pathologists. PMID:31075510
A longitudinal big data approach for precision health. PMID:31068711
g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). PMID:31066453
Evaluation of the impact of single-nucleotide polymorphisms on treatment response, survival and toxicity with cytarabine and anthracyclines in patients with acute myeloid leukaemia: a systematic review protocol. PMID:31053175
Pharmacogenomics in dermatology: tools for understanding gene-drug associations. PMID:31051019
Personalized medicine: going to the dogs? PMID:31032534
PGxO and PGxLOD: a reconciliation of pharmacogenomic knowledge of various provenances, enabling further comparison. PMID:30999867
Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants. PMID:30987408
Population Pharmacogenomics for Precision Public Health in Colombia. PMID:30967898
Pharmacogenetics in the Treatment of Cardiovascular Diseases and Its Current Progress Regarding Implementation in the Clinical Routine. PMID:30939847
Pharmacogenomic considerations for antiplatelet agents: the era of precision medicine in stroke prevention and neurointerventional practice. PMID:30936195
Actionable Pharmacogenetic Variation in the Slovenian Genomic Database. PMID:30930780
Pathway genes and metabolites in thiopurine therapy in Korean children with acute lymphoblastic leukaemia. PMID:30927276
Management of severe arterial hypertension associated with serotonin syndrome: a case report analysis based on systematic review techniques. PMID:30886699
Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users. PMID:30870275
Pharmacogenomics of Multiple Sclerosis: A Systematic Review. PMID:30863357
Translating Pharmacogenetics and Pharmacogenomics to the Clinic: Progress in Human and Veterinary Medicine. PMID:30854372
Germline susceptibility variants impact clinical outcome and therapeutic strategies for stage III colorectal cancer. PMID:30850667
UniProt genomic mapping for deciphering functional effects of missense variants. PMID:30840782
Much ado about nothing: A qualitative study of the experiences of an average-risk population receiving results of exome sequencing. PMID:30835913
Advancing Personalized Medicine Through the Application of Whole Exome Sequencing and Big Data Analytics. PMID:30809243
Moving pharmacoepigenetics tools for depression toward clinical use. PMID:30802699
Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy. PMID:30801677
Effects of genetic variability on rifampicin and isoniazid pharmacokinetics in South African patients with recurrent tuberculosis. PMID:30767706
A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort. PMID:30766545
Precision dosing of warfarin: open questions and strategies. PMID:30745565
The future of myeloma precision medicine: integrating the compendium of known drug resistance mechanisms with emerging tumor profiling technologies. PMID:30683909
Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning. PMID:30652029
Large-scale analysis of human gene expression variability associates highly variable drug targets with lower drug effectiveness and safety. PMID:30649201
Pharmacogenomics of amlodipine and hydrochlorothiazide therapy and the quest for improved control of hypertension: a mini review. PMID:30645721
BioTransformer: a comprehensive computational tool for small molecule metabolism prediction and metabolite identification. PMID:30612223
Returning a Genomic Result for an Adult-Onset Condition to the Parents of a Newborn: Insights From the BabySeq Project. PMID:30600270
Ensembl variation resources. PMID:30576484
The sequencing and interpretation of the genome obtained from a Serbian individual. PMID:30566479
ATP-Binding Cassette Transporters in the Clinical Implementation of Pharmacogenetics. PMID:30563187
PathFX provides mechanistic insights into drug efficacy and safety for regulatory review and therapeutic development. PMID:30532240
Genetic Polymorphisms Associated with Spontaneous Intracerebral Hemorrhage. PMID:30518145
Using Electronic Health Records To Generate Phenotypes For Research. PMID:30516347
High-frequency actionable pathogenic exome variants in an average-risk cohort. PMID:30487145
Uncovering the mechanism of Maxing Ganshi Decoction on asthma from a systematic perspective: A network pharmacology study. PMID:30478434
Characterization of ADME genes variation in Roma and 20 populations worldwide. PMID:30452466
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. PMID:30423114
Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records. PMID:30420678
Pharmacogenetics of Membrane Transporters of Tacrolimus in Solid Organ Transplantation. PMID:30415459
Ensembl 2019. PMID:30407521
Essential Characteristics of Pharmacogenomics Study Publications. PMID:30406943
The Integrating Pharmacogenetics in Clinical Care (I-PICC) Study: Protocol for a point-of-care randomized controlled trial of statin pharmacogenetics in primary care. PMID:30367991
Implementing Clinical Pharmacogenomics in the Classroom: Student Pharmacist Impressions of an Educational Intervention Including Personal Genotyping. PMID:30360487
Drug Repositioning to Accelerate Drug Development Using Social Media Data: Computational Study on Parkinson Disease. PMID:30309833
Uncovering association networks through an eQTL analysis involving human miRNAs and lincRNAs. PMID:30301969
Comparative transcriptomic profile of tolerogenic dendritic cells differentiated with vitamin D3, dexamethasone and rapamycin. PMID:30297862
Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction. PMID:30232231
Establishing a stable, repeatable platform for measuring changes in sperm DNA methylation. PMID:30227883
Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes. PMID:30214008
The role of solute carrier (SLC) transporters in actinomycin D pharmacokinetics in paediatric cancer patients. PMID:30167756
Impact of SLCO1B1 Pharmacogenetic Testing on Patient and Healthcare Outcomes: A Systematic Review. PMID:30137643
How to Determine the Role of the Microbiome in Drug Disposition. PMID:30111623
Computational resources associating diseases with genotypes, phenotypes and exposures. PMID:30102366
PharmacoDB: an integrative database for mining in vitro anticancer drug screening studies. PMID:30053271
Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey. PMID:30042363
A Computational Systems Pharmacology Approach to Investigate Molecular Mechanisms of Herbal Formula Tian-Ma-Gou-Teng-Yin for Treatment of Alzheimer's Disease. PMID:29997503
The BabySeq project: implementing genomic sequencing in newborns. PMID:29986673
A systematic assessment of the availability and clinical drug information coverage of machine-readable clinical drug data sources for building knowledge translation products. PMID:29982512
Application of pharmacogenetics in clinical practice: problems and solutions. PMID:29922908
Tissue-Specific Analysis of Pharmacological Pathways. PMID:29920991
Standardization can accelerate the adoption of pharmacogenomics: current status and the path forward. PMID:29914287
The Emerging Potential for Network Analysis to Inform Precision Cancer Medicine. PMID:29908887
Evaluation of buccal swabs for pharmacogenetics. PMID:29898767
Uridine 5'-diphospho-glucronosyltrasferase: Its role in pharmacogenomics and human disease. PMID:29896223
Exploring the Potential of Direct-To-Consumer Genomic Test Data for Predicting Adverse Drug Events. PMID:29888082
CATCH-KB: Establishing a Pharmacogenomics Variant Repository for Chemotherapy-Induced Cardiotoxicity. PMID:29888066
Pharmacogenomic Approaches for Automated Medication Risk Assessment in People with Polypharmacy. PMID:29888060
A systematic approach for identifying shared mechanisms in epilepsy and its comorbidities. PMID:29873705
Antidiabetic and Antiobesity Effects of Artemether in db/db Mice. PMID:29862294
Pharmacogenetic testing in the Veterans Health Administration (VHA): policy recommendations from the VHA Clinical Pharmacogenetics Subcommittee. PMID:29858578
Value of Genetics-informed Drug Dosing Guidance in Pregnant Women: A Needs Assessment with Obstetric Healthcare Providers at Johns Hopkins. PMID:29854203
Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. PMID:29853970
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. PMID:29808027
Clinical Pharmacogenomics: Applications in Nephrology. PMID:29793969
The impact of pharmacokinetic gene profiles across human cancers. PMID:29783934
The relative resistance of children to sepsis mortality: from pathways to drug candidates. PMID:29773677
Effect of single-dose imipramine on chronic low-back and experimental pain. A randomized controlled trial. PMID:29742109
In silico epigenetics of metal exposure and subclinical atherosclerosis in middle aged men: pilot results from the Aragon Workers Health Study. PMID:29685964
Community Dissemination in a Tribal Health Setting: A Pharmacogenetics Case Study. PMID:29671859
Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients. PMID:29668600
Pharmacogenomics and big genomic data: from lab to clinic and back again. PMID:29635477
Pharmacokinetics of efavirenz in patients on antituberculosis treatment in high human immunodeficiency virus and tuberculosis burden countries: A systematic review. PMID:29624706
Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine. PMID:29620484
Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia. PMID:29567674
Identification of a less toxic vinca alkaloid derivative for use as a chemotherapeutic agent, based on in silico structural insights and metabolic interactions with CYP3A4 and CYP3A5. PMID:29502215
A global network of biomedical relationships derived from text. PMID:29490008
Research Techniques Made Simple: Using Genome-Wide Association Studies to Understand Complex Cutaneous Disorders. PMID:29477192
Recon3D enables a three-dimensional view of gene variation in human metabolism. PMID:29457794
Pharmacogenomics-guided policy in opioid use disorder (OUD) management: An ethnically-diverse case-based approach. PMID:29450233
The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants. PMID:29431110
Safety and Preliminary Efficacy of Vorinostat With R-EPOCH in High-risk HIV-associated Non-Hodgkin's Lymphoma (AMC-075). PMID:29426719
Clinical Pharmacogenetic Models of Treatment Response to Methotrexate Monotherapy in Slovenian and Serbian Rheumatoid Arthritis Patients: Differences in Patient's Management May Preclude Generalization of the Models. PMID:29422864
Integrated Theory- and Data-driven Feature Selection in Gene Expression Data Analysis. PMID:29422764
Biosignature Discovery for Substance Use Disorders Using Statistical Learning. PMID:29409736
The pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants. PMID:29400612
An interaction between warfarin and cannabidiol, a case report. PMID:29387536
Are we ready for genetic testing for primary open-angle glaucoma? PMID:29379103
Drug drug interaction extraction from the literature using a recursive neural network. PMID:29373599
Scuba: scalable kernel-based gene prioritization. PMID:29370760
Deep learning of mutation-gene-drug relations from the literature. PMID:29368597
Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population. PMID:29362361
Ontogeny-related pharmacogene changes in the pediatric liver transcriptome. PMID:29360682
Muscle molecular adaptations to endurance exercise training are conditioned by glycogen availability: a proteomics-based analysis in the McArdle mouse model. PMID:29315579
A Genome-Wide Association Study Identifies a Candidate Gene Associated With Atazanavir Exposure Measured in Hair. PMID:29315502
Genome scale metabolic models as tools for drug design and personalized medicine. PMID:29304175
Genetic variation in human drug-related genes. PMID:29273096
Bioinformatics for precision oncology. PMID:29272324
Enhancing the Promise of Drug Repositioning through Genetics. PMID:29270124
Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences. PMID:29263805
eGARD: Extracting associations between genomic anomalies and drug responses from text. PMID:29261751
In-Cardiome: integrated knowledgebase for coronary artery disease enabling translational research. PMID:29220465
Chemical reaction vector embeddings: towards predicting drug metabolism in the human gut microbiome. PMID:29218869
Pharmacogenetic Variation in Over 100 Genes in Patients Receiving Acenocumarol. PMID:29218011
Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis. PMID:29210323
Biomarkers: Delivering on the expectation of molecularly driven, quantitative health. PMID:29199461
Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research. PMID:29193890
Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years. PMID:29193749
Pharmacokinetics of CYP2C9, CYP2C19, and CYP2D6 substrates in healthy Chinese and European subjects. PMID:29181698
Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans. PMID:29178968
The Diversity of REcent and Ancient huMan (DREAM): A New Microarray for Genetic Anthropology and Genealogy, Forensics, and Personalized Medicine. PMID:29165562
Combination antiretroviral therapy accelerates immune recovery in patients with HIV-related lymphoma treated with EPOCH: a comparison within one prospective trial AMC034. PMID:29160731
The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484. PMID:29142105
Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors. PMID:29126409
Clinical Pharmacogenetics of Cytochrome P450-Associated Drugs in Children. PMID:29099060
Pharmacogenomics DNA Biomarkers in Colorectal Cancer: Current Update. PMID:29075194
A Network Pharmacology Approach to Determine the Active Components and Potential Targets of Curculigo Orchioides in the Treatment of Osteoporosis. PMID:29074841
Antituberculosis Drug-Induced Adverse Events in the Liver, Kidneys, and Blood: Clinical Profiles and Pharmacogenetic Predictors. PMID:29071720
System Pharmacology-Based Dissection of the Synergistic Mechanism of Huangqi and Huanglian for Diabetes Mellitus. PMID:29051733
Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients. PMID:29036176
Toward a Personalized Real-Time Diagnosis in Neonatal Seizure Detection. PMID:29021923
Comparison of the Guidelines of the Clinical Pharmacogenetics Implementation Consortium and the Dutch Pharmacogenetics Working Group. PMID:28994452
Expression of Genes for Methylxanthine Pathway-Associated Enzymes Accompanied by Sex Steroid Receptor Status Impacts Breast Carcinoma Progression. PMID:28971320
Quantitative and Systems Pharmacology. 1. In Silico Prediction of Drug-Target Interactions of Natural Products Enables New Targeted Cancer Therapy. PMID:28956927
Primer in Genetics and Genomics, Article 5-Further Defining the Concepts of Genotype and Phenotype and Exploring Genotype-Phenotype Associations. PMID:28920489
Analysis of population-specific pharmacogenomic variants using next-generation sequencing data. PMID:28871186
Cell Surface Proteomics of N-Linked Glycoproteins for Typing of Human Lymphocytes. PMID:28834292
Effect of Efavirenz on Endogenous Progesterone Concentrations and Contraceptive Outcomes among Ugandan HIV Infected Women Coadministering Ethinylestradiol/Levonorgestrel. PMID:28831309
CYP2C19*2 and CYP2C19*17 variants and effect of tamoxifen on breast cancer recurrence: Analysis of the International Tamoxifen Pharmacogenomics Consortium dataset. PMID:28798474
New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine. PMID:28795399
Exploring public genomics data for population pharmacogenomics. PMID:28771511
CYP2D6 genotype is not associated with survival in breast cancer patients treated with tamoxifen: results from a population-based study. PMID:28730340
Quality assurance of chemical ingredient classification for the National Drug File - Reference Terminology. PMID:28723580
Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events. PMID:28679691
Bioinformatory-assisted analysis of next-generation sequencing data for precision medicine in pancreatic cancer. PMID:28675654
Chemotherapy-induced peripheral neurotoxicity: management informed by pharmacogenetics. PMID:28664909
Effects of atorvastatin and simvastatin on oxidative stress in diet-induced hyperhomocysteinemia in Wistar albino rats: a comparative study. PMID:28620818
Genetic background influences susceptibility to chemotherapy-induced hematotoxicity. PMID:28607509
Cost-effectiveness of pharmacogenetic-guided treatment: are we there yet? PMID:28607506
Pharmacogenomic findings from clinical whole exome sequencing of diagnostic odyssey patients. PMID:28546997
Network mirroring for drug repositioning. PMID:28539121
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants. PMID:28537254
Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer. PMID:28448657
minepath.org: a free interactive pathway analysis web server. PMID:28431175
Learning from biomedical linked data to suggest valid pharmacogenes. PMID:28427468
The Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance Treatment. PMID:28391009
SNPPhenA: a corpus for extracting ranked associations of single-nucleotide polymorphisms and phenotypes from literature. PMID:28388928
The druggable genome and support for target identification and validation in drug development. PMID:28356508
ADH1B: From alcoholism, natural selection, and cancer to the human phenome. PMID:28349588
Predicting drug-drug interactions through drug structural similarities and interaction networks incorporating pharmacokinetics and pharmacodynamics knowledge. PMID:28316654
Drug voyager: a computational platform for exploring unintended drug action. PMID:28241745
Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives. PMID:28230749
Personalized medicine: Genetic risk prediction of drug response. PMID:28213088
Systematic analyses of drugs and disease indications in RepurposeDB reveal pharmacological, biological and epidemiological factors influencing drug repositioning. PMID:28200013
CYP2D6 Genetic Variation and Beta-Blocker Maintenance Dose in Patients with Heart Failure. PMID:28181117
Next-Generation Sequencing in Oncology: Genetic Diagnosis, Risk Prediction and Cancer Classification. PMID:28146134
Phenotype-Specific Association of Single-Nucleotide Polymorphisms with Heart Failure and Preserved Ejection Fraction: a Genome-Wide Association Analysis of the Cardiovascular Health Study. PMID:28105587
MicroRNAs are important regulators of drug resistance in colorectal cancer. PMID:28095367
Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach. PMID:28074863
A Survey of Computational Tools to Analyze and Interpret Whole Exome Sequencing Data. PMID:28070503
Flexible and Scalable Full-Length CYP2D6 Long Amplicon PacBio Sequencing. PMID:28044414
Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines. PMID:28029011
Recommendations for Optimizing Tuberculosis Treatment: Therapeutic Drug Monitoring, Pharmacogenetics, and Nutritional Status Considerations. PMID:28028995
Incorporating Pharmacogenomics into Health Information Technology, Electronic Health Record and Decision Support System: An Overview. PMID:27987157
The BioGRID interaction database: 2017 update. PMID:27980099
Microbial phenomics information extractor (MicroPIE): a natural language processing tool for the automated acquisition of prokaryotic phenotypic characters from text sources. PMID:27955641
Open Targets: a platform for therapeutic target identification and validation. PMID:27899665
STRATEGIES FOR EQUITABLE PHARMACOGENOMIC-GUIDED WARFARIN DOSING AMONG EUROPEAN AND AFRICAN AMERICAN INDIVIDUALS IN A CLINICAL POPULATION. PMID:27897005
MathIOmica: An Integrative Platform for Dynamic Omics. PMID:27883025
Educational strategies to enable expansion of pharmacogenomics-based care. PMID:27864206
Evidence and resources to implement pharmacogenetic knowledge for precision medicine. PMID:27864205
Implementation of inpatient models of pharmacogenetics programs. PMID:27864202
Efficacy and Safety of High-Dose Ivermectin for Reducing Malaria Transmission (IVERMAL): Protocol for a Double-Blind, Randomized, Placebo-Controlled, Dose-Finding Trial in Western Kenya. PMID:27856406
Danish clinical quality databases - an important and untapped resource for clinical research. PMID:27843338
The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients. PMID:27785404
Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations. PMID:27757066
Pharmacogenomics of statins: understanding susceptibility to adverse effects. PMID:27757045
Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases. PMID:27738338
Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches. PMID:27721455
A machine-learned computational functional genomics-based approach to drug classification. PMID:27695919
Multidisciplinary model to implement pharmacogenomics at the point of care. PMID:27657685
Pharmacogenomics and Global Precision Medicine in the Context of Adverse Drug Reactions: Top 10 Opportunities and Challenges for the Next Decade. PMID:27643672
Prevalence and characteristics of adverse drug reactions at admission to hospital: a prospective observational study. PMID:27640819
ePGA: A Web-Based Information System for Translational Pharmacogenomics. PMID:27631363
Pharmacogenomics in Pediatric Oncology: Review of Gene-Drug Associations for Clinical Use. PMID:27618021
Genetics of Common Antipsychotic-Induced Adverse Effects. PMID:27606321
Role of pharmacogenetics in public health and clinical health care: a SWOT analysis. PMID:27577547
Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma. PMID:27566582
A Cytochrome P450 3A4 Biosensor Based on Generation 4.0 PAMAM Dendrimers for the Detection of Caffeine. PMID:27548239
Discovering gene expression signatures responding to tyrosine kinase inhibitor treatment in chronic myeloid leukemia. PMID:27534394
Databases and tools for constructing signal transduction networks in cancer. PMID:27502015
Frequency distribution of polymorphisms of CYP2C19, CYP2C9, VKORC1 and SLCO1B1 genes in the Yakut population. PMID:27499796
Prediction of scaffold proteins based on protein interaction and domain architectures. PMID:27490120
Context-specific functional module based drug efficacy prediction. PMID:27490093
A Multi-scale Computational Platform to Mechanistically Assess the Effect of Genetic Variation on Drug Responses in Human Erythrocyte Metabolism. PMID:27467583
Genomics era and complex disorders: Implications of GWAS with special reference to coronary artery disease, type 2 diabetes mellitus, and cancers. PMID:27424552
Pharmacogenomics for infectious diseases in sub-Saharan Africa: Successes and opportunities. PMID:27354934
Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment. PMID:27347216
Creating a scalable clinical pharmacogenomics service with automated interpretation and medical record result integration - experience from a pediatric tertiary care facility. PMID:27301749
The Role of Metabotropic Glutamate Receptor Genes in Schizophrenia. PMID:27296644
Genetic polymorphisms of pharmacogenomic VIP variants in the Mongol of Northwestern China. PMID:27233804
Research Resources for Nuclear Receptor Signaling Pathways. PMID:27216565
Practical aspects of NGS-based pathways analysis for personalized cancer science and medicine. PMID:27191992
High-performance web services for querying gene and variant annotation. PMID:27154141
Mirror, mirror on the wall: which microbiomes will help heal them all? PMID:27146150
A whole genome analyses of genetic variants in two Kelantan Malay individuals. PMID:27090252
In silico methods for drug repurposing and pharmacology. PMID:27080087
BRONCO: Biomedical entity Relation ONcology COrpus for extracting gene-variant-disease-drug relations. PMID:27074804
DiMeX: A Text Mining System for Mutation-Disease Association Extraction. PMID:27073839
Developing knowledge resources to support precision medicine: principles from the Clinical Pharmacogenetics Implementation Consortium (CPIC). PMID:27026620
Utilizing yeast chemogenomic profiles for the prediction of pharmacogenomic associations in humans. PMID:27025271
Pharmacogenetic Risk Scores for Perindopril Clinical and Cost Effectiveness in Stable Coronary Artery Disease: When Are We Ready to Implement? PMID:27021567
Recent Advances in Application of Pharmacogenomics for Biotherapeutics. PMID:27007601
Genetic Association of Curative and Adverse Reactions to Tyrosine Kinase Inhibitors in Chinese advanced Non-Small Cell Lung Cancer patients. PMID:26988277
Advancing Pharmacogenomics Education in the Core PharmD Curriculum through Student Personal Genomic Testing. PMID:26941429
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach. PMID:26915512
A high-precision rule-based extraction system for expanding geospatial metadata in GenBank records. PMID:26911818
Health regulatory communications of well-established safety-related pharmacogenomics associations in six developed countries: an evaluation of alignment. PMID:26902540
Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network. PMID:26857349
Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. PMID:26856248
Unique β-Glucuronidase Locus in Gut Microbiomes of Crohn's Disease Patients and Unaffected First-Degree Relatives. PMID:26824357
Activation of the Constitutive Androstane Receptor Increases the Therapeutic Index of CHOP in Lymphoma Treatment. PMID:26823489
Impact of germline and somatic missense variations on drug binding sites. PMID:26810135
Accelerating Adverse Outcome Pathway Development Using Publicly Available Data Sources. PMID:26809562
The Outlier in All of Us: Why Implementing Pharmacogenomics Could Matter for Everyone. PMID:26756170
Assessing the Costs and Cost-Effectiveness of Genomic Sequencing. PMID:26690481
Genetic Polymorphisms Analysis of Pharmacogenomic VIP Variants in Miao Ethnic Group of Southwest China. PMID:26632549
RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles. PMID:26597164
CancerResource--updated database of cancer-relevant proteins, mutations and interacting drugs. PMID:26590406
Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery. PMID:26579539
Human genotype-phenotype databases: aims, challenges and opportunities. PMID:26553330
Next generation informatics for big data in precision medicine era. PMID:26539249
Comparing the Therapeutic Effectiveness of N-acetylcysteine with the Combination of N-acetyl Cysteine and Cimetidine in Acute Acetaminophen Toxicity: A Double-Blinded Clinical Trial. PMID:26516435
Generalized Multifactor Dimensionality Reduction (GMDR) Analysis of Drug-Metabolizing Enzyme-Encoding Gene Polymorphisms may Predict Treatment Outcomes in Indian Breast Cancer Patients. PMID:26506825
Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort. PMID:26503815
Pharmacogenetics of healthy volunteers in Puerto Rico. PMID:26501165
Virtual Pharmacist: A Platform for Pharmacogenomics. PMID:26496198
Pharmacogenomics in the clinic. PMID:26469045
Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data. PMID:26448358
Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: implications for clinical implementation of pharmacogenomics. PMID:26444257
Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics. PMID:26410689
A fast and high performance multiple data integration algorithm for identifying human disease genes. PMID:26399620
Computational drug repositioning for peripheral arterial disease: prediction of anti-inflammatory and pro-angiogenic therapeutics. PMID:26379552
Secure Genomic Computation through Site-Wise Encryption. PMID:26306278
Achieving high-sensitivity for clinical applications using augmented exome sequencing. PMID:26269718
Prospective participant selection and ranking to maximize actionable pharmacogenetic variants and discovery in the eMERGE Network. PMID:26221186
Learning the Structure of Biomedical Relationships from Unstructured Text. PMID:26219079
Using gene expression signatures to identify novel treatment strategies in gulf war illness. PMID:26156520
Metrabase: a cheminformatics and bioinformatics database for small molecule transporter data analysis and (Q)SAR modeling. PMID:26106450
A weighted and integrated drug-target interactome: drug repurposing for schizophrenia as a use case. PMID:26100720
Tools for visualization and analysis of molecular networks, pathways, and -omics data. PMID:26082651
Evidence for Clinical Implementation of Pharmacogenomics in Cardiac Drugs. PMID:26046407
Discovering transnosological molecular basis of human brain diseases using biclustering analysis of integrated gene expression data. PMID:26043779
PANDA: pathway and annotation explorer for visualizing and interpreting gene-centric data. PMID:26038725
OncoRep: an n-of-1 reporting tool to support genome-guided treatment for breast cancer patients using RNA-sequencing. PMID:25989980
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. PMID:25974703
KnowLife: a versatile approach for constructing a large knowledge graph for biomedical sciences. PMID:25971816
Adverse Drug Event-based Stratification of Tumor Mutations: A Case Study of Breast Cancer Patients Receiving Aromatase Inhibitors. PMID:25954427
Evolutionary Diagnosis of non-synonymous variants involved in differential drug response. PMID:25952014
PGMD: a comprehensive manually curated pharmacogenomic database. PMID:25939485
Differential Natural Selection of Human Zinc Transporter Genes between African and Non-African Populations. PMID:25927708
EPMA position paper in cancer: current overview and future perspectives. PMID:25908947
Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature. PMID:25860377
Comparing a knowledge-driven approach to a supervised machine learning approach in large-scale extraction of drug-side effect relationships from free-text biomedical literature. PMID:25860223
Local modulation of steroid action: rapid control of enzymatic activity. PMID:25852459
The promise of multi-omics and clinical data integration to identify and target personalized healthcare approaches in autism spectrum disorders. PMID:25831060
Analysis of pharmacogenomic variants associated with population differentiation. PMID:25807276
Pharmacogenetics and outcome with antipsychotic drugs. PMID:25733959
A systematic approach to the reporting of medically relevant findings from whole genome sequencing. PMID:25714468
Web resources for pharmacogenomics. PMID:25703229
Enabling the curation of your pharmacogenetic study. PMID:25670512
Systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb Folium eriobotryae. PMID:25636035
A one-page summary report of genome sequencing for the healthy adult. PMID:25612602
Incorporation of personal single nucleotide polymorphism (SNP) data into a national level electronic health record for disease risk assessment, part 1: an overview of requirements. PMID:25599712
An In Silico Approach towards the Prediction of Druglikeness Properties of Inhibitors of Plasminogen Activator Inhibitor1. PMID:25580120
Germline oncopharmacogenetics, a promising field in cancer therapy. PMID:25573079
Pharmacogenomics of antimicrobial agents. PMID:25495412
Combining automatic table classification and relationship extraction in extracting anticancer drug-side effect pairs from full-text articles. PMID:25445920
Pharmacogenetics of drug-metabolizing enzymes in US Hispanics. PMID:25431893
Genomic landscape of metastatic colorectal cancer. PMID:25394515
Predicting cancer prognosis using functional genomics data sets. PMID:25392695
An update on the pharmacogenetics of treating hypertension. PMID:25355012
Identifying disease genes by integrating multiple data sources. PMID:25350511
Genome-wide discovery of drug-dependent human liver regulatory elements. PMID:25275310
Hybrid curation of gene-mutation relations combining automated extraction and crowdsourcing. PMID:25246425
Using Drosophila melanogaster to identify chemotherapy toxicity genes. PMID:25236447
Pharmacogenetics of Statin-Induced Myopathy: A Focused Review of the Clinical Translation of Pharmacokinetic Genetic Variants. PMID:25221728
Principal component analysis characterizes shared pathogenetics from genome-wide association studies. PMID:25211452
Integrative genomic analysis identifies that SERPINA6-rs1998056 regulated by FOXA/ERα is associated with female hepatocellular carcinoma. PMID:25198130
Preappointment testing for BRAF/KIT mutation in advanced melanoma: a model in molecular data delivery for individualized medicine. PMID:25179409
Pharmacogenetic research in partnership with American Indian and Alaska Native communities. PMID:25141898
FOLFOX/FOLFIRI pharmacogenetics: the call for a personalized approach in colorectal cancer therapy. PMID:25132748
A phenome-guided drug repositioning through a latent variable model. PMID:25103881
Clinical pharmacogenetics implementation consortium guidelines for CYP2C9 and HLA-B genotypes and phenytoin dosing. PMID:25099164
Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer. PMID:25096367
Systems pharmacology dissection of multi-scale mechanisms of action for herbal medicines in stroke treatment and prevention. PMID:25093322
Relevance of G-quadruplex structures to pharmacogenetics. PMID:25071578
In silico comparative characterization of pharmacogenomic missense variants. PMID:25057096
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data. PMID:25048637
Evidence synthesis and guideline development in genomic medicine: current status and future prospects. PMID:24946156
Automatic construction of a large-scale and accurate drug-side-effect association knowledge base from biomedical literature. PMID:24928448
Increased genetic diversity of ADME genes in African Americans compared with their putative ancestral source populations and implications for pharmacogenomics. PMID:24884825
Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. PMID:24853734
A 32-Year-Old Female with AIDS, Pneumocystis jiroveci Pneumonia, and Methemoglobinemia. PMID:24829836
The personal genome browser: visualizing functions of genetic variants. PMID:24799434
Clinical interpretation and implications of whole-genome sequencing. PMID:24618965
The Semanticscience Integrated Ontology (SIO) for biomedical research and knowledge discovery. PMID:24602174
Dosage individualization of warfarin using artificial neural networks. PMID:24574079
The pharmacogenetics of type 2 diabetes: a systematic review. PMID:24558078
A quantitative analysis of the mass media coverage of genomics medicine in China: a call for science journalism in the developing world. PMID:24512309
Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process. PMID:24479687
Using semantic predications to uncover drug-drug interactions in clinical data. PMID:24448204
Targeted therapy by combined inhibition of the RAF and mTOR kinases in malignant spindle cell neoplasm harboring the KIAA1549-BRAF fusion protein. PMID:24422672
Prioritizing genomic applications for action by level of evidence: a horizon-scanning method. PMID:24398597
Endothelial nitric oxide synthase polymorphisms and haplotypes in genetic epidemiology and pharmacogenetics: remarks regarding a lack of association on the risk of myocardial infarction. PMID:24395292
Translation of genetics research to clinical medicine: the National Heart, Lung, and Blood Institute perspective. PMID:24347619
Current clinical evidence on pioglitazone pharmacogenomics. PMID:24324437
PharmGKB Drug Data Normalization with NDF-RT. PMID:24303334
A Framework of Knowledge Integration and Discovery for Supporting Pharmacogenomics Target Predication of Adverse Drug Events: A Case Study of Drug-Induced Long QT Syndrome. PMID:24303306
Annotating cancer variants and anti-cancer therapeutics in reactome. PMID:24213504
Practical challenges in integrating genomic data into the electronic health record. PMID:24071798
Navigating traditional chinese medicine network pharmacology and computational tools. PMID:23983798
PharmGKB summary: very important pharmacogene information for the epidermal growth factor receptor. PMID:23962910
Towards precision medicine: advances in computational approaches for the analysis of human variants. PMID:23962656
Pharmacogenomics in early-phase clinical development. PMID:23837482
Pathway analysis of genome-wide data improves warfarin dose prediction. PMID:23819817
Disambiguation of PharmGKB drug-disease relations with NDF-RT and SPL. PMID:23727027
Challenges in the pharmacogenomic annotation of whole genomes. PMID:23708745
Characterization of the genetic variation present in CYP3A4 in three South African populations. PMID:23423246
Nomenclature for alleles of the thiopurine methyltransferase gene. PMID:23407052
The NIH genetic testing registry: a new, centralized database of genetic tests to enable access to comprehensive information and improve transparency. PMID:23193275
Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array. PMID:22910441 -
Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base
PubMed citations: 142.
142 articles citing: Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base
Lack of association of CYP2B6 pharmacogenetics with cyclophosphamide toxicity in patients with cancer. PMID:35606478
Extracting Concepts for Precision Oncology from the Biomedical Literature. PMID:34457142
A novel computational drug repurposing approach for Systemic Lupus Erythematosus (SLE) treatment using Semantic Web technologies. PMID:34220244
Pharmacogenetics to guide cardiovascular drug therapy. PMID:33953382
Artificial Intelligence in Cancer Research and Precision Medicine. PMID:33811123
Precision Population Medicine in Primary Care: The Sanford Chip Experience. PMID:33777099
Identification of new proteins related with cisplatin resistance in Saccharomyces cerevisiae. PMID:33576883
A computational approach to predict multi-pathway drug-drug interactions: A case study of irinotecan, a colon cancer medication. PMID:33424244
Divergent organ-specific isogenic metastatic cell lines identified using multi-omics exhibit differential drug sensitivity. PMID:33196681
CYP2D6 genotype may moderate measures of brain structure in methamphetamine users. PMID:32767519
Are gene polymorphisms related to adverse events of methotrexate in patients with rheumatoid arthritis? A retrospective cohort study based on an updated meta-analysis. PMID:32426102
Applying Pharmacogenomics to Antifungal Selection and Dosing: Are We There Yet? PMID:32256938
Evaluation of knowledge graph embedding approaches for drug-drug interaction prediction in realistic settings. PMID:31852427
A Review of Bioinformatics Tools to Understand Acetaminophen-Alcohol Interaction. PMID:31349598
The sequencing and interpretation of the genome obtained from a Serbian individual. PMID:30566479
A Systems-Level Analysis of Mechanisms of Platycodon grandiflorum Based on A Network Pharmacological Approach. PMID:30388815
Pharmacogenomic studies of hypertension: paving the way for personalized antihypertensive treatment. PMID:29888336
PharmGKB: A worldwide resource for pharmacogenomic information. PMID:29474005
Dengue virus causes changes of MicroRNA-genes regulatory network revealing potential targets for antiviral drugs. PMID:29301573
Identifying genotype-phenotype relationships in biomedical text. PMID:29212530
Differential prioritization of therapies to subtypes of triple negative breast cancer using a systems medicine method. PMID:29190967
Regulation of Pharmacogene Expression by microRNA in The Cancer Genome Atlas (TCGA) Research Network. PMID:28835003
Strategies towards digital and semi-automated curation in RegulonDB. PMID:28365731
CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice. PMID:28296354
Data-Driven Prediction of Beneficial Drug Combinations in Spontaneous Reporting Systems. PMID:28269877
Drug-drug interaction discovery and demystification using Semantic Web technologies. PMID:28031284
Minimum information required for a DMET experiment reporting. PMID:27548815
Towards precision medicine. PMID:27528417
Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis. PMID:27379764
Bridging semantics and syntax with graph algorithms-state-of-the-art of extracting biomedical relations. PMID:26851224
Bringing clinical pharmacogenomics information to pharmacists: A qualitative study of information needs and resource requirements. PMID:26725696
Dealing with the Data Deluge: Handling the Multitude Of Chemical Biology Data Sources. PMID:26609498
EHR based Genetic Testing Knowledge Base (iGTKB) Development. PMID:26606281
A Semantic Web-based System for Mining Genetic Mutations in Cancer Clinical Trials. PMID:26306257
Construction of a drug safety assurance information system based on clinical genotyping. PMID:25969745
A decision support framework for genomically informed investigational cancer therapy. PMID:25863335
Personalization of the immunosuppressive treatment in renal transplant recipients: the great challenge in "omics" medicine. PMID:25690039
Multi-omic landscape of rheumatoid arthritis: re-evaluation of drug adverse effects. PMID:25414848
In-vivo fusion of human cancer and hamster stromal cells permanently transduces and transcribes human DNA. PMID:25259521
Towards structural systems pharmacology to study complex diseases and personalized medicine. PMID:24830652
Improved candidate drug mining for Alzheimer's disease. PMID:24719894
Modular network construction using eQTL data: an analysis of computational costs and benefits. PMID:24616734
Integrating systems biology sources illuminates drug action. PMID:24577151
Using semantic predications to uncover drug-drug interactions in clinical data. PMID:24448204
Genetic and non-genetic determinants of raltegravir penetration into cerebrospinal fluid: a single arm pharmacokinetic study. PMID:24349334
ModBase, a database of annotated comparative protein structure models and associated resources. PMID:24271400
Integrative gene set analysis: application to platinum pharmacogenomics. PMID:24199607
The Coriell personalized medicine collaborative pharmacogenomics appraisal, evidence scoring and interpretation system. PMID:24134832
Pharmacogenomic Discovery Delineating the Genetic Basis of Drug Response. PMID:24015375
Influence of CYP3A4 genotypes in the outcome of serous ovarian cancer patients treated with first-line chemotherapy: implication of a CYP3A4 activity profile. PMID:23936594
RMOD: a tool for regulatory motif detection in signaling network. PMID:23874612
Compensating for literature annotation bias when predicting novel drug-disease relationships through Medical Subject Heading Over-representation Profile (MeSHOP) similarity. PMID:23819887
Large numbers of genetic variants considered to be pathogenic are common in asymptomatic individuals. PMID:23818451
A genome-wide integrative study of microRNAs in human liver. PMID:23758991
A semi-supervised approach to extract pharmacogenomics-specific drug-gene pairs from biomedical literature for personalized medicine. PMID:23570835
Pharmacometabolomics reveals racial differences in response to atenolol treatment. PMID:23536766
An iterative searching and ranking algorithm for prioritising pharmacogenomics genes. PMID:23428471
Informatics confronts drug-drug interactions. PMID:23414686
Using the OntoGene pipeline for the triage task of BioCreative 2012. PMID:23396322
Pharmaco-miR: linking microRNAs and drug effects. PMID:23376192
Chapter 2: Data-driven view of disease biology. PMID:23300408
Exome sequencing of only seven Qataris identifies potentially deleterious variants in the Qatari population. PMID:23139751
Top Three Pharmacogenomics and Personalized Medicine Applications at the Nexus of Renal Pathophysiology and Cardiovascular Medicine. PMID:23049672
Ranking relations between diseases, drugs and genes for a curation task. PMID:23046495
Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases. PMID:22988944
Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization. PMID:22938713
Identifying novel drug indications through automated reasoning. PMID:22911721
Identifying the genetic variation of gene expression using gene sets: application of novel gene Set eQTL approach to PharmGKB and KEGG. PMID:22905253
A public resource facilitating clinical use of genomes. PMID:22797899
Allele and genotype frequencies of the polymorphic cytochrome P450 genes (CYP1A1, CYP3A4, CYP3A5, CYP2C9 and CYP2C19) in the Jordanian population. PMID:22722998
A mutation-centric approach to identifying pharmacogenomic relations in text. PMID:22683993
Pharmacogene regulatory elements: from discovery to applications. PMID:22630332
A knowledge-driven conditional approach to extract pharmacogenomics specific drug-gene relationships from free text. PMID:22561026
Systematic identification of pharmacogenomics information from clinical trials. PMID:22546622
Deriving rules and assertions from pharmacogenomics knowledge resources in support of patient drug metabolism efficacy predictions. PMID:22539082
Using ODIN for a PharmGKB revalidation experiment. PMID:22529178
Charting the NF-κB pathway interactome map. PMID:22403694
A weighted accumulation test for associating rare genetic variation with quantitative phenotypes. PMID:22373271
Drug-target network in myocardial infarction reveals multiple side effects of unrelated drugs. PMID:22355571
Mixed effects modeling of proliferation rates in cell-based models: consequence for pharmacogenomics and cancer. PMID:22346769
Gene set analysis of survival following ovarian cancer implicates macrolide binding and intracellular signaling genes. PMID:22302016
Large-scale elucidation of drug response pathways in humans. PMID:22300318
Integrating heterogeneous high-throughput data for meta-dimensional pharmacogenomics and disease-related studies. PMID:22256870
Semantically enabling pharmacogenomic data for the realization of personalized medicine. PMID:22256869
Systems pharmacology: network analysis to identify multiscale mechanisms of drug action. PMID:22235860
Ranking gene-drug relationships in biomedical literature using Latent Dirichlet Allocation. PMID:22174297
Discovery and explanation of drug-drug interactions via text mining. PMID:22174296
From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource. PMID:22103613
Aldehyde dehydrogenase 1A1 expression in breast cancer is associated with stage, triple negativity, and outcome to neoadjuvant chemotherapy. PMID:22080062
Human metabolic individuality in biomedical and pharmaceutical research. PMID:21886157
Cancer pharmacogenomics. PMID:21796115
Is pharmacogenomics a reality? Challenges and oppurtunities for India. PMID:21747581
Analysis of pharmacogenetic traits in two distinct South African populations. PMID:21712189
Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases. PMID:21695124
Integration and publication of heterogeneous text-mined relationships on the Semantic Web. PMID:21624156
Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis. PMID:21515602
Pharmacogenetics and clopidogrel response in patients undergoing percutaneous coronary interventions. PMID:21270785
Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study. PMID:21178985
The emerging role of microRNAs in drug responses. PMID:21154161
ModBase, a database of annotated comparative protein structure models, and associated resources. PMID:21097780
IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data. PMID:21087994
Pediatric pharmacogenetic and pharmacogenomic studies: the current state and future perspectives. PMID:21069522
Recent progress in automatically extracting information from the pharmacogenomic literature. PMID:21047206
Integrative systems biology for data-driven knowledge discovery. PMID:21044756
Genotator: a disease-agnostic tool for genetic annotation of disease. PMID:21034472
Exprtarget: an integrative approach to predicting human microRNA targets. PMID:20975837
Pharmacogenomics in pediatric leukemia. PMID:20861736
Using text to build semantic networks for pharmacogenomics. PMID:20723615
Publishing Chinese medicine knowledge as Linked Data on the Web. PMID:20663193
Genome-wide association studies in pharmacogenomics: successes and lessons. PMID:20639796
Irinotecan pharmacogenomics. PMID:20602618
Pharmacogenetics of heart failure: evidence, opportunities, and challenges for cardiovascular pharmacogenomics. PMID:20559955
Chem2Bio2RDF: a semantic framework for linking and data mining chemogenomic and systems chemical biology data. PMID:20478034
Clinical assessment incorporating a personal genome. PMID:20435227
A comprehensive molecular interaction map for rheumatoid arthritis. PMID:20419126
Pharmacogenomics and bioinformatics: PharmGKB. PMID:20350130
Impact of the 1000 genomes project on the next wave of pharmacogenomic discovery. PMID:20136363
Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response. PMID:20031551
Use of cell lines in the investigation of pharmacogenetic loci. PMID:19925429
Improving the prediction of pharmacogenes using text-derived drug-gene relationships. PMID:19908383
Personalized medicine for diabetes. PMID:19885196
The NCBI BioSystems database. PMID:19854944
The SLCO1B1*5 genetic variant is associated with statin-induced side effects. PMID:19833260
CanGeneBase (CGB)--a database on cancer related genes. PMID:19759863
An onco-informatics database for anticancer drug interactions with complementary and alternative medicines used in cancer treatment and supportive care: an overview of the OncoRx project. PMID:19756775
A pharmacogene database enhanced by the 1000 Genomes Project. PMID:19745786
Human genomic diversity, viral genomics and proteomics, as exemplified by human papillomaviruses and H5N1 influenza viruses. PMID:19706363
Computing with evidence Part II: An evidential approach to predicting metabolic drug-drug interactions. PMID:19539050
Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. PMID:19498075
A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine. PMID:19309514
IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. PMID:18948278
Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks. PMID:18782832
The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics. PMID:18392109
First confirmed autochthonous case of human Babesia microti infection in Europe. PMID:17587072
Identification of NR1I2 genetic variation using resequencing. PMID:17404718
The pharmacogenetics research network: from SNP discovery to clinical drug response. PMID:17339863
PharmGED: Pharmacogenetic Effect Database. PMID:17151074
Bio-ontologies: current trends and future directions. PMID:16899495
A statistical approach to scanning the biomedical literature for pharmacogenetics knowledge. PMID:15561790
Forensic genetics and ethical, legal and social implications beyond the clinic. PMID:15510102
Finding haplotype tagging SNPs by use of principal components analysis. PMID:15389393
PharmGKB: the Pharmacogenetics Knowledge Base. PMID:11752281
Tags:
Tags
More detailed information about this field from each metasource.
approved drug
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
classification
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
drug
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
gene
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
gene expression data
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
gene-disease association
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
genotype
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
pathway model
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
phenotype
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
sequence variant
metasource: Fairsharing.org
version: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
human genes and diseases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
general polymorphism databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
other molecular biology databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
drugs and drug design
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
biology
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
drug response
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
drug pathway
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
genetics
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
human
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
microarray
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
pharmacogenetics
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
pharmacogenomics
metasource: re3data.org
version: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:43.873620
genotype and phenotype
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:43.873620
pharmacology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:43.873620
human biology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:43.873620
rare diseases
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:43.873620
Tags
More detailed information about this field from each metasource.
approved drug
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
classification
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
drug
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
gene
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
gene expression data
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
gene-disease association
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
genotype
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
pathway model
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
phenotype
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
sequence variant
metasource: Fairsharing.orgversion: FAIRsharing.org: PharmGKB; Pharmacogenomics Knowledge Base; DOI: https://doi.org/10.25504/FAIRsharing.t7yckc; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
human genes and diseases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
general polymorphism databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
other molecular biology databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
drugs and drug design
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
biology
metasource: re3data.orgversion: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
drug response
metasource: re3data.orgversion: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
drug pathway
metasource: re3data.orgversion: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
genetics
metasource: re3data.orgversion: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
human
metasource: re3data.orgversion: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
microarray
metasource: re3data.orgversion: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
pharmacogenetics
metasource: re3data.orgversion: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
pharmacogenomics
metasource: re3data.orgversion: re3data.org: PharmGKB; editing status 2019-01-25; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31H1N last accessed: 2022-11-04
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:43.873620
genotype and phenotype
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:30:43.873620
pharmacology
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:30:43.873620
human biology
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:30:43.873620
rare diseases
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:30:43.873620
approved drug classification drug gene gene expression gene-disease association genotype pathway model phenotype sequence variant human genes and diseases polymorphism molecular biology drug drug response drug pathway genetics human microarray pharmacogenetics pharmacogenomics genotype and phenotype pharmacology human rare diseases
Need help integrating and/or managing biomedical data?