VARIDT

The Variability of Drug Transporter Database (VARIDT) is constructed to provide the comprehensive data of all aspects of drug transporter variability. Based on the comprehensive review on all FDA approved and >2,000 clinical trial drugs, VARIDT confirmed 266 transporters, for the first time, as the drug transporters (DTs) of clinical importance. For these confirmed DTs, VARIDT comprehensively collected all aspects of their variability (23,947 DNA methylations, 7,317 noncoding RNA/histone regulations, 1,278 genetic polymorphisms, differential abundance profiles of 257 DTs in 21,781 patients/healthy individuals, expression of 245 DTs in 67 tissues of human/model organism, 1,225 exogenous factors altering the activity of 148 DTs), which allowed mutual connection between any aspects. Due to huge amount of accumulated data, VARIDT made it possible to generalize characteristics to reveal disease etiology and optimize clinical treatment.

Webpage:
https://db.idrblab.org/varidt/

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molecular biology drug

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