Human Protein Atlas
Names
More detailed information about this field from each metasource.
Human Protein Atlas
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
HPA
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-07-05
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
The Human Protein Atlas
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-07-05
metasource: bio.tools
version: extracted_at: 2022-07-05T15:35:45.170853
proteinatlas
metasource: bio.tools
version: extracted_at: 2022-07-05T15:35:45.170853
Names
More detailed information about this field from each metasource.
Human Protein Atlas
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
HPA
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-07-05
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
The Human Protein Atlas
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-07-05
metasource: bio.tools
version: extracted_at: 2022-07-05T15:35:45.170853
proteinatlas
metasource: bio.toolsversion: extracted_at: 2022-07-05T15:35:45.170853
Other names: HPA, The Human Protein Atlas, proteinatlas
Names
More detailed information about this field from each metasource.
Human Protein Atlas
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
HPA
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-07-05
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
The Human Protein Atlas
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-07-05
metasource: bio.tools
version: extracted_at: 2022-07-05T15:35:45.170853
proteinatlas
metasource: bio.toolsversion: extracted_at: 2022-07-05T15:35:45.170853
The Human Protein Atlas is program started with the aim to map of all the human proteins in cells, tissues and organs using integration of various omics technologies. It consists of three parts: Tissue Atlas showing the distribution of proteins across tissues and organs in the human body, the Cell Atlas showing the subcellular localization of proteins in single cells and Pathology Atlas showing the impact of protein levels for survival of patients with cancer.
Description
More detailed information about this field from each metasource.
The Human Protein Atlas is program started with the aim to map of all the human proteins in cells, tissues and organs using integration of various omics technologies. It consists of three parts: Tissue Atlas showing the distribution of proteins across tissues and organs in the human body, the Cell Atlas showing the subcellular localization of proteins in single cells and Pathology Atlas showing the impact of protein levels for survival of patients with cancer.
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-07-06T08:29:30.521553
The Human Protein Atlas (HPA) portal is a publicly available database with millions of high-resolution images showing the spatial distribution of proteins in a number of different wild-type tissues, cancer types and human cell lines. The goal of the HPA is to map all the human proteins in cells, tissues and organs using an integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics and systems biology. The HPA is composed of six parts: the Tissue Atlas, the Single Cell Type Atlas, the Pathology Atlas, the Blood Atlas, the Brain Atlas, and the Cell Atlas.
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
The Swedish Human Protein Atlas project has been set up to allow for a systematic exploration of the human proteome using Antibody-Based Proteomics. This is accomplished by combining high-throughput generation of affinity-purified antibodies with protein profiling in a multitude of tissues and cells assembled in tissue microarrays. Confocal microscopy analysis using human cell lines is performed for more detailed protein localization. The program hosts the Human Protein Atlas portal with expression profiles of human proteins in tissues and cells. The main objective of the resource centre is to produce specific antibodies to human target proteins using a high-throughput production method involving the cloning and protein expression of Protein Epitope Signature Tags (PrESTs). After purification, the antibodies are used to study expression profiles in cells and tissues and for functional analysis of the corresponding proteins in a wide range of platforms.
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-07-05
Database with millions of high-resolution images. Expression and localization of proteins in a large variety of normal human tissues, cancer cells and cell lines with the aid of immunohistochemistry (IHC) images and immunofluorescence (IF) confocal microscopy images.
metasource: bio.toolsversion: extracted_at: 2022-07-05T15:35:45.170853
Webpage:
https://www.proteinatlas.orgWebpage
More detailed information about this field from each metasource.
https://www.proteinatlas.org
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-07-06T08:29:30.521553
https://www.proteinatlas.org/
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-07-05
http://www.proteinatlas.org/
metasource: bio.toolsversion: extracted_at: 2022-07-05T15:35:45.170853
Licence:
Name: Creative Commons Attribution-ShareAlike v3.0Licence name
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Creative Commons Attribution-ShareAlike v3.0
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-07-06T08:29:30.521553
Creative Commons Attribution-ShareAlike 3.0 Unported (CC BY-SA 3.0)
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
other
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-07-05
Licence URL
More detailed information about this field from each metasource.
https://www.proteinatlas.org/about/licence
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-07-06T08:29:30.521553
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-07-05
https://creativecommons.org/licenses/by-sa/3.0/
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Publications:
(9)
Publications
More detailed information about this field from each metasource.
Proteomics. Tissue-based map of the human proteome
PMID: 25613900
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A pathology atlas of the human cancer transcriptome
PMID: 28818916
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Towards a knowledge-based Human Protein Atlas
PMID: 21139605
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A subcellular map of the human proteome
PMID: 28495876
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A human protein atlas for normal and cancer tissues based on antibody proteomics
PMID: 16127175
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
The Human Protein Atlas--a tool for pathology
PMID: 18853439
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A genecentric Human Protein Atlas for expression profiles based on antibodies
PMID: 18669619
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Transcriptomics resources of human tissues and organs
PMID: 27044256
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
http://dx.doi.org/10.1126/science.1260419
metasource: bio.tools
version: extracted_at: 2022-07-05T15:35:45.170853
Publications
More detailed information about this field from each metasource.
Proteomics. Tissue-based map of the human proteome
PMID: 25613900
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A pathology atlas of the human cancer transcriptome
PMID: 28818916
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Towards a knowledge-based Human Protein Atlas
PMID: 21139605
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A subcellular map of the human proteome
PMID: 28495876
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A human protein atlas for normal and cancer tissues based on antibody proteomics
PMID: 16127175
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-07-06T08:29:30.521553
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
The Human Protein Atlas--a tool for pathology
PMID: 18853439
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A genecentric Human Protein Atlas for expression profiles based on antibodies
PMID: 18669619
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Transcriptomics resources of human tissues and organs
PMID: 27044256
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
http://dx.doi.org/10.1126/science.1260419
metasource: bio.toolsversion: extracted_at: 2022-07-05T15:35:45.170853
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Proteomics. Tissue-based map of the human proteome
PubMed citations: 4415.
4415 articles citing: Proteomics. Tissue-based map of the human proteome
Study on the role of transcription factor SPI1 in the development of glioma. PMID:35361282
Identification of Pathologic and Prognostic Genes in Prostate Cancer Based on Database Mining. PMID:35360870
Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients. PMID:35360718
Impact of Vimentin on Regulation of Cell Signaling and Matrix Remodeling. PMID:35359446
Ras and Rab Interactor 3: From Cellular Mechanisms to Human Diseases. PMID:35359443
Single-Cell RNA Sequencing Revealed a 3-Gene Panel Predicted the Diagnosis and Prognosis of Thyroid Papillary Carcinoma and Associated With Tumor Immune Microenvironment. PMID:35359404
KIF26B in the Prognosis and Immune Biomarking of Various Cancers: A Pan-Cancer Study. PMID:35359341
Antigen-Specific TCR-T Cells for Acute Myeloid Leukemia: State of the Art and Challenges. PMID:35356211
Integrating protein copy numbers with interaction networks to quantify stoichiometry in clathrin-mediated endocytosis. PMID:35354856
Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids. PMID:35354790
The emerging role of mass spectrometry-based proteomics in drug discovery. PMID:35351998
Comparing Urinary Glycoproteins among Three Urogenital Cancers and Identifying Prostate Cancer-Specific Glycoproteins. PMID:35350332
Identification of Novel Molecular Therapeutic Targets and Their Potential Prognostic Biomarkers Based on Cytolytic Activity in Skin Cutaneous Melanoma. PMID:35345444
Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach. PMID:35339898
In vitro culture at 39 °C during hepatic maturation of human ES cells facilitates hepatocyte-like cell functions. PMID:35338220
The landscape of receptor-mediated precision cancer combination therapy via a single-cell perspective. PMID:35338126
Discovery of Proteins Responsible for Resistance to Three Chemotherapy Drugs in Breast Cancer Cells Using Proteomics and Bioinformatics Analysis. PMID:35335125
Overexpressing PLOD Family Genes Predict Poor Prognosis in Pancreatic Cancer. PMID:35330878
The Prognostic Relevance of PMCA4 Expression in Melanoma: Gender Specificity and Implications for Immune Checkpoint Inhibition. PMID:35328746
GLUT3/SLC2A3 Is an Endogenous Marker of Hypoxia in Prostate Cancer Cell Lines and Patient-Derived Xenograft Tumors. PMID:35328229
Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases. PMID:35327608
A Gene Co-Expression Network-Based Drug Repositioning Approach Identifies Candidates for Treatment of Hepatocellular Carcinoma. PMID:35326724
Molecular Characterization of Portuguese Patients with Hereditary Cerebellar Ataxia. PMID:35326432
Chemokine CCL17 Affects Local Immune Infiltration Characteristics and Early Prognosis Value of Lung Adenocarcinoma. PMID:35321241
A Novel Tissue Atlas and Online Tool for the Interrogation of Small RNA Expression in Human Tissues and Biofluids. PMID:35317387
Neutrophils Require Activation to Express Functional Cell-Surface Complement Receptor Immunoglobulin. PMID:35317169
Neurotrophic receptor tyrosine kinase family members in secretory and non-secretory breast carcinomas. PMID:35316931
Differential parathyroid and kidney Ca2+-sensing receptor activation in autosomal dominant hypocalcemia 1. PMID:35313217
CCDC134 as a Prognostic-Related Biomarker in Breast Cancer Correlating With Immune Infiltrates. PMID:35311121
Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium. PMID:35309931
Identification of a Methylation-Regulating Genes Prognostic Signature to Predict the Prognosis and Aid Immunotherapy of Clear Cell Renal Cell Carcinoma. PMID:35309925
Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects. PMID:35309357
Discovering Novel Biomarkers Associated with the Pathogenesis of Psoriasis: Evidence from Bioinformatic Analysis. PMID:35300136
Roles of Pyroptosis-Related Gene Signature in Prediction of Endometrial Cancer Outcomes. PMID:35299842
Substrate Stiffness Determines the Establishment of Apical-Basal Polarization in Renal Epithelial Cells but Not in Tubuloid-Derived Cells. PMID:35299632
A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer. PMID:35289315
Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy. PMID:35288587
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. PMID:35288557
Simple method for cutoff point identification in descriptive high-throughput biological studies. PMID:35287573
New associations of serum β-carotene, lycopene, and zeaxanthin concentrations with NR1H3, APOB, RDH12, AND CYP genes. PMID:35282004
Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis. PMID:35281427
Energy Metabolism-Related Gene Prognostic Index Predicts Biochemical Recurrence for Patients With Prostate Cancer Undergoing Radical Prostatectomy. PMID:35280985
Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety. PMID:35280519
Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes. PMID:35279219
Interplay Between the Immune and Endocrine Systems in the Lung: Implications for TB Susceptibility. PMID:35273609
Ficolin-2 Plasma Level Assesses Liver Fibrosis in Non-Alcoholic Fatty Liver Disease. PMID:35269955
PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power. PMID:35267575
Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates. PMID:35264686
The Role of GJD2(Cx36) in Refractive Error Development. PMID:35262731
Pan-cancer analysis of osteogenesis imperfecta causing gene SERPINF1. PMID:35261846
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination. PMID:35256818
Polo-like kinases as potential targets and PLK2 as a novel biomarker for the prognosis of human glioblastoma. PMID:35256538
Smoking Status and Type 2 Diabetes, and Cardiovascular Disease: A Comprehensive Analysis of Shared Genetic Etiology and Causal Relationship. PMID:35250867
A Dynamic Mass Redistribution Assay for the Human Sweet Taste Receptor Uncovers G-Protein Dependent Biased Ligands. PMID:35250580
Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions. PMID:35250281
Reconstruction and analysis of a large-scale binary Ras-effector signaling network. PMID:35246154
In-Depth Profiling of O-Glycan Isomers in Human Cells Using C18 Nanoliquid Chromatography-Mass Spectrometry and Glycogenomics. PMID:35245040
Promoter/enhancer-based controllability of regulatory networks. PMID:35241702
Antibodies in the intracellular domain. PMID:35241366
LPAR2 correlated with different prognosis and immune cell infiltration in head and neck squamous cell carcinoma and kidney renal clear cell carcinoma. PMID:35241179
Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19. PMID:35237273
Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate. PMID:35228743
Roles of transposable elements in the regulation of mammalian transcription. PMID:35228718
Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation. PMID:35226415
Inhibition of NEK7 Suppressed Hepatocellular Carcinoma Progression by Mediating Cancer Cell Pyroptosis. PMID:35223495
Identification of CCL19 as a Novel Immune-Related Biomarker in Diabetic Nephropathy. PMID:35222545
A DNA-Methylation-Driven Genes Based Prognostic Signature Reveals Immune Microenvironment in Pancreatic Cancer. PMID:35222383
Developing Biomarkers of Mild Traumatic Brain Injury: Promise and Progress of CNS-Derived Exosomes. PMID:35222223
BEND4 as a Candidate Gene for an Infection-Induced Acute Encephalopathy Characterized by a Cyst and Calcification of the Pons and Cerebellar Atrophy. PMID:35221871
SCNN1A Overexpression Correlates with Poor Prognosis and Immune Infiltrates in Ovarian Cancer. PMID:35221714
AP-4-mediated axonal transport controls endocannabinoid production in neurons. PMID:35217685
A Novel Role of Arrhythmia-Related Gene KCNQ1 Revealed by Multi-Omic Analysis: Theragnostic Value and Potential Mechanisms in Lung Adenocarcinoma. PMID:35216393
Novel Role of Ghrelin Receptor in Gut Dysbiosis and Experimental Colitis in Aging. PMID:35216335
Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels. PMID:35216288
Investigating Glioblastoma Multiforme Sub-Proteomes: A Computational Study of CUSA Fluid Proteomic Data. PMID:35216175
Prodynorphin and Proenkephalin in Cerebrospinal Fluid of Sporadic Creutzfeldt-Jakob Disease. PMID:35216166
Interferon-β Activity Is Affected by S100B Protein. PMID:35216109
Hepatic CYP3A4 Enzyme Compensatively Maintains Endogenous Geranylgeranoic Acid Levels in MAOB-Knockout Human Hepatoma Cells. PMID:35208214
IL4Rα and IL13Rα1 Are Involved in the Development of Human Gallbladder Cancer. PMID:35207737
The Pseudokinase TRIB1 in Immune Cells and Associated Disorders. PMID:35205759
Characterization and Functional Study of FAM49B Reveals Its Effect on Cell Proliferation in HEK293T Cells. PMID:35205432
A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors. PMID:35205150
Cytoplasmic and Nuclear Functions of cIAP1. PMID:35204822
Leukemia Inhibitory Factor: An Important Cytokine in Pathologies and Cancer. PMID:35204717
Identifying Mitotic Kinesins as Potential Prognostic Biomarkers in Ovarian Cancer Using Bioinformatic Analyses. PMID:35204562
A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene? PMID:35204159
Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma. PMID:35203444
Cancer chemoprevention through Frizzled receptors and EMT. PMID:35201483
Genetic associations of protein-coding variants in human disease. PMID:35197637
The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication. PMID:35197452
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer. PMID:35197278
Systematic illumination of druggable genes in cancer genomes. PMID:35196490
[Web-based gene expression analysis-paving the way to decode healthy and diseased ocular tissue]. PMID:35194679
Evaluation of an 131I-labeled HER2-specific single domain antibody fragment for the radiopharmaceutical therapy of HER2-expressing cancers. PMID:35194100
Postnatal expression of IGF2 is the norm in amniote vertebrates. PMID:35193406
A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer. PMID:35191375
The Role of Muscle Ring Finger-1 (MuRF1), MuRF2, MuRF3, and Atrogin-1 on Bone Microarchitecture In Vivo. PMID:35191000
Analysis of recent shared ancestry in a familial cohort identifies coding and noncoding autism spectrum disorder variants. PMID:35190550
Immune Characteristics of LYN in Tumor Microenvironment of Gliomas. PMID:35186945
Single-Cell Technologies to Decipher the Immune Microenvironment in Myeloid Neoplasms: Perspectives and Opportunities. PMID:35186713
Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells. PMID:35183204
Transcription factor protein interactomes reveal genetic determinants in heart disease. PMID:35182466
Cellular specificity of mitochondrial and immunometabolic features in major depression. PMID:35181755
ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells. PMID:35181635
Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications. PMID:35177642
Blood-brain barrier dysfunction in L-ornithine induced acute pancreatitis in rats and the direct effect of L-ornithine on cultured brain endothelial cells. PMID:35177109
Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia. PMID:35172124
A human brain vascular atlas reveals diverse mediators of Alzheimer's risk. PMID:35165441
Inhibition of Protein N-Glycosylation Blocks SARS-CoV-2 Infection. PMID:35164559
Disruption of Kidney-Immune System Crosstalk in Sepsis with Acute Kidney Injury: Lessons Learned from Animal Models and Their Application to Human Health. PMID:35163625
Identification of a Novel Theranostic Signature of Metabolic and Immune-Inflammatory Dysregulation in Myocardial Infarction, and the Potential Therapeutic Properties of Ovatodiolide, a Diterpenoid Derivative. PMID:35163208
P-Glycoprotein and Androgen Receptor Expression Reveals Independence of Canine Prostate Cancer from Androgen Hormone Stimulation. PMID:35163087
Transcriptomic Response to Acidosis Reveals Its Contribution to Bone Metastasis in Breast Cancer Cells. PMID:35159353
Landscape of Epidermal Growth Factor Receptor Heterodimers in Brain Metastases. PMID:35158800
Selenium binding protein 1 inhibits tumor angiogenesis in colorectal cancers by blocking the Delta-like ligand 4/Notch1 signaling pathway. PMID:35158204
Adherence Enables Neisseria gonorrhoeae to Overcome Zinc Limitation Imposed by Nutritional Immunity Proteins. PMID:35156850
Comprehensive and Integrative Analysis of Two Novel SARS-CoV-2 Entry Associated Proteases CTSB and CTSL in Healthy Individuals and Cancer Patients. PMID:35155389
Whole-Exome Sequencing Implicates Neuronal Calcium Channel with Familial Atrial Fibrillation. PMID:35154276
Identification of a Novel Nomogram to Predict Progression Based on the Circadian Clock and Insights Into the Tumor Immune Microenvironment in Prostate Cancer. PMID:35154101
Insights Into the Emergence of Paroxysmal Nocturnal Hemoglobinuria. PMID:35154088
Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer. PMID:35153749
ERCC6L is a biomarker and therapeutic target for non-small cell lung adenocarcinoma. PMID:35150321
Machine learning prediction and tau-based screening identifies potential Alzheimer's disease genes relevant to immunity. PMID:35149761
The spatial transcriptomic landscape of the healing mouse intestine following damage. PMID:35149721
A mammalian methylation array for profiling methylation levels at conserved sequences. PMID:35145108
High male specific contribution of the X-chromosome to individual global recombination rate in dairy cattle. PMID:35144552
RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells. PMID:35143476
14-3-3 Proteins are Potential Regulators of Liquid-Liquid Phase Separation. PMID:35142991
Glioma targeted therapy: insight into future of molecular approaches. PMID:35135556
Analysis of SARS-CoV-2 synonymous codon usage evolution throughout the COVID-19 pandemic. PMID:35134624
Early immune responses have long-term associations with clinical, virologic, and immunologic outcomes in patients with COVID-19. PMID:35132407
KLRK1 as a prognostic biomarker for lung adenocarcinoma cancer. PMID:35132098
Combined assessment of MHC binding and antigen abundance improves T cell epitope predictions. PMID:35128348
Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer. PMID:35127694
Enhancer RNA LINC00242-Induced Expression of PHF10 Drives a Better Prognosis in Pancreatic Adenocarcinoma. PMID:35127503
Shared Genetic Architecture and Causal Relationship Between Asthma and Cardiovascular Diseases: A Large-Scale Cross-Trait Analysis. PMID:35126453
The Expression of Inflammasomes NLRP1 and NLRP3, Toll-Like Receptors, and Vitamin D Receptor in Synovial Fibroblasts From Patients With Different Types of Knee Arthritis. PMID:35126351
Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment. PMID:35122074
The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets. PMID:35121907
RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4+ T-cell-dependent antitumor immunity. PMID:35121884
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. PMID:35120601
Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis. PMID:35119778
Expression Profiles of Estrogen-Regulated MicroRNAs in Cancer Cells. PMID:35119673
Pyruvate kinase M2 is a marker of poor prognosis in lung adenocarcinoma but not lung squamous cell carcinoma. PMID:35117696
Multi-omics analysis reveals the BRCA1 mutation and mismatch repair gene signatures associated with survival, protein expression, and copy number alterations in prostate cancer. PMID:35116870
Sideroflexin1 as a novel tumor marker independently predicts survival in lung adenocarcinoma. PMID:35116859
Bioinformatic analysis of PLOD family member expression and prognostic value in non-small cell lung cancer. PMID:35116582
The role of TRIM51 as a multipurpose biomarker in melanoma. PMID:35116291
GOLM1 as a Potential Therapeutic Target Modulates B7-H3 Secretion to Drive Ovarian Cancer Metastasis. PMID:35116068
Exploring the Multi-Tissue Crosstalk Relevant to Insulin Resistance Through Network-Based Analysis. PMID:35116003
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines. PMID:35115730
AKR1C1/2 inhibition by MPA sensitizes platinum resistant ovarian cancer towards carboplatin. PMID:35115586
Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis. PMID:35113855
Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates. PMID:35110592
Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation. PMID:35110545
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study. PMID:35106505
Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids. PMID:35106453
The Impact of Nonalcoholic Fatty Liver Disease on the Outcomes of Coronavirus Disease 2019 Infection. PMID:35106147
Galectins as potential therapeutic targets in STIs in the female genital tract. PMID:35105978
ER-phagy requires the assembly of actin at sites of contact between the cortical ER and endocytic pits. PMID:35101986
Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer. PMID:35101137
ZNF146/OZF and ZNF507 target LINE-1 sequences. PMID:35100360
Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types. PMID:35100265
Novel Classes and Evolutionary Turnover of Histone H2B Variants in the Mammalian Germline. PMID:35099534
Potential Clinical Value of Biomarker-Guided Emergency Triage for Thoracic Aortic Dissection. PMID:35096998
TMC5 is Highly Expressed in Human Cancers and Corelates to Prognosis and Immune Cell Infiltration: A Comprehensive Bioinformatics Analysis. PMID:35096973
The FUT2 Variant c.461G>A (p.Trp154*) Is Associated With Differentially Expressed Genes and Nasopharyngeal Microbiota Shifts in Patients With Otitis Media. PMID:35096646
Prognostic Signatures and Therapeutic Value Based on the Notch Pathway in Renal Clear Cell Carcinoma. PMID:35096263
Construction and Validation of a Newly Prognostic Signature for CRISPR-Cas9-Based Cancer Dependency Map Genes in Breast Cancer. PMID:35096059
Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury. PMID:35091838
Cortical and Subcortical Dysmetabolism Are Dynamic Markers of Clinical Disability and Course in Anti-LGI1 Encephalitis. PMID:35091466
CANT1 serves as a potential prognostic factor for lung adenocarcinoma and promotes cell proliferation and invasion in vitro. PMID:35090419
Faster skin wound healing predicts survival after myocardial infarction. PMID:35089808
Integrin-linked kinase (ILK): the known vs. the unknown and perspectives. PMID:35089438
AXIN-AMPK signaling: Implications for healthy aging. PMID:35087668
Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing. PMID:35085231
Emerging Progress in Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum: Challenges and Opportunities. PMID:35083256
Expressing the Human Cholesteryl Ester Transfer Protein Minigene Improves Diet-Induced Fatty Liver and Insulin Resistance in Female Mice. PMID:35082691
The Age-Specific Features and Clinical Significance of NRF2 and MAPK10 Expression in HCC Patients. PMID:35082522
Alternative splicing regulation of membrane trafficking genes during myogenesis. PMID:35082143
A genome-wide association study of serum proteins reveals shared loci with common diseases. PMID:35078996
Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells. PMID:35078919
Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource. PMID:35078504
High complement protein C1q levels in pulmonary fibrosis and non-small cell lung cancer associated with poor prognosis. PMID:35078421
Serotonin: an overlooked regulator of endocytosis and endosomal sorting? PMID:35076063
The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation. PMID:35076027
Genome-wide annotation of protein-coding genes in pig. PMID:35073880
Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM. PMID:35073561
Identification of a novel pyroptosis-related gene signature correlated with the prognosis of diffuse glioma patients. PMID:35071460
High expression of Ran binding protein 1 predicts poor outcomes in hepatocellular carcinoma patients: a Cancer Genome Atlas database analysis. PMID:35070423
Mechanism of SARS-CoV-2 Invasion into the Liver and Hepatic Injury in Patients with COVID-19. PMID:35070210
Comprehensive Pan-Cancer Genomic Analysis Reveals PHF19 as a Carcinogenic Indicator Related to Immune Infiltration and Prognosis of Hepatocellular Carcinoma. PMID:35069553
High expression of PDZ-binding kinase is correlated with poor prognosis and immune infiltrates in hepatocellular carcinoma. PMID:35065633
Impact of ADAR-induced editing of minor viral RNA populations on replication and transmission of SARS-CoV-2. PMID:35064076
Selective Deletion of the Mechanistic Target of Rapamycin From the Renal Collecting Duct Principal Cell in Mice Down-Regulates the Epithelial Sodium Channel. PMID:35058797
Identification of an ACK1/TNK2-based prognostic signature for colon cancer to predict survival and inflammatory landscapes. PMID:35057760
The Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature. PMID:35055804
Clin.iobio: A Collaborative Diagnostic Workflow to Enable Team-Based Precision Genomics. PMID:35055388
Identifying Candidate Protein Markers of Acute Kidney Injury in Acute Decompensated Heart Failure. PMID:35055195
Syndecan-4 Is a Key Facilitator of the SARS-CoV-2 Delta Variant's Superior Transmission. PMID:35054983
Bisphenol S Impairs Invasion and Proliferation of Extravillous Trophoblasts Cells by Interfering with Epidermal Growth Factor Receptor Signaling. PMID:35054855
Telomere and Telomerase-Associated Proteins in Endometrial Carcinogenesis and Cancer-Associated Survival. PMID:35054812
CircFISH: A Novel Method for the Simultaneous Imaging of Linear and Circular RNAs. PMID:35053590
Smell Detection Agent Optimisation Framework and Systems Biology Approach to Detect Dys-Regulated Subnetwork in Cancer Data. PMID:35053185
LRP6 Receptor Plays Essential Functions in Development and Human Diseases. PMID:35052459
Preclinical Research in McArdle Disease: A Review of Research Models and Therapeutic Strategies. PMID:35052414
Circulatory MicroRNAs in Plasma and Atrial Fibrillation in the General Population: The Rotterdam Study. PMID:35052352
SATB2 and MDM2 Immunoexpression and Diagnostic Role in Primary Osteosarcomas of the Jaw. PMID:35049602
Multi-Omics Analysis for Transcriptional Regulation of Immune-Related Targets Using Epigenetic Data: A New Research Direction. PMID:35046932
Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model. PMID:35046474
The Mlc1 Promoter Directs Müller Cell-specific Gene Expression in the Retina. PMID:35040915
Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer. PMID:35040374
Harnessing big data to characterize immune-related adverse events. PMID:35039679
Stabilization and structure determination of integral membrane proteins by termini restraining. PMID:35039670
Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity. PMID:35036073
Loss of full-length pumilio 1 abrogates miRNA-221-induced gene p27 silencing-mediated cell proliferation in the heart. PMID:35036057
Core promoter mutation contributes to abnormal gene expression in bladder cancer. PMID:35033028
Renin-angiotensin system blockade on angiotensin-converting enzyme 2 and TMPRSS2 in human type II pneumocytes. PMID:35032553
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids. PMID:35032430
Calcium selective channel TRPV6: Structure, function, and implications in health and disease. PMID:35031425
Computer-aided design of reversible hybridization chain reaction (CAD-HCR) enables multiplexed single-cell spatial proteomics imaging. PMID:35030012
Characterization and use of the ECV304 autoantigenic citrullinome to understand anti-citrullinated protein/peptide autoantibodies in rheumatoid arthritis. PMID:35027076
IBEX: an iterative immunolabeling and chemical bleaching method for high-content imaging of diverse tissues. PMID:35022622
The amniotic fluid proteome changes with gestational age in normal pregnancy: a cross-sectional study. PMID:35022423
Connexin 43 confers chemoresistance through activating PI3K. PMID:35022385
Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene. PMID:35015732
Synthesis of broad-specificity activity-based probes for exo-β-mannosidases. PMID:35015006
Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. PMID:35013352
A de novo paradigm for male infertility. PMID:35013161
Endosomal Recycling Defects and Neurodevelopmental Disorders. PMID:35011709
The Sulfotransferase SULT1C2 Is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and Is Associated with Patient Outcome in Lung Adenocarcinoma. PMID:35010676
AGC1 Deficiency: Pathology and Molecular and Cellular Mechanisms of the Disease. PMID:35008954
Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma. PMID:35008509
Anticancer Activities of 9-chloro-6-(piperazin-1-yl)-11H-indeno[1,2-c] quinolin-11-one (SJ10) in Glioblastoma Multiforme (GBM) Chemoradioresistant Cell Cycle-Related Oncogenic Signatures. PMID:35008426
Targeting Post-Translational Regulation of p53 in Colorectal Cancer by Exploiting Vulnerabilities in the p53-MDM2 Axis. PMID:35008383
A Gene Signature Derived from the Loss of CDKN1A (p21) Is Associated with CMS4 Colorectal Cancer. PMID:35008299
HPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes. PMID:35008200
Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single-cell analysis. PMID:35007307
Integrated bioinformatics and experiments reveal the roles and driving forces for HSF1 in colorectal cancer. PMID:35006040
LCK and CD3E Orchestrate the Tumor Microenvironment and Promote Immunotherapy Response and Survival of Muscle-Invasive Bladder Cancer Patients. PMID:35004669
CD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a pigmented melanoma model. PMID:35003897
Cytochrome b561 Serves as a Potential Prognostic Biomarker and Target for Breast Cancer. PMID:35002301
Circulating Tumor Cell Transcriptomics as Biopsy Surrogates in Metastatic Breast Cancer. PMID:35000083
Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells. PMID:34999972
The proprotein convertase furin in cancer: more than an oncogene. PMID:34997216
Identification of Key Transcription Factors and Immune Infiltration Patterns Associated With Breast Cancer Prognosis Using WGCNA and Cox Regression Analysis. PMID:34993131
Identification of ubiquitinated substrate proteins and their gene expression patterns in lung adenocarcinoma. PMID:34988201
High Expression of Ubiquitin-Specific Protease 39 and Its Roles in Prognosis in Patients with Hepatocellular Carcinoma. PMID:34987596
RNA profiles reveal signatures of future health and disease in pregnancy. PMID:34987224
LRG1 as a novel therapeutic target in eye disease. PMID:34987199
TF-Marker: a comprehensive manually curated database for transcription factors and related markers in specific cell and tissue types in human. PMID:34986601
A test of the pioneer factor hypothesis using ectopic liver gene activation. PMID:34984978
Convergent evolution of venom gland transcriptomes across Metazoa. PMID:34983844
Regulation of fatty acid desaturase- and immunity gene-expression by mbk-1/DYRK1A in Caenorhabditis elegans. PMID:34983389
Chlamydomonas ARMC2/PF27 is an obligate cargo adapter for intraflagellar transport of radial spokes. PMID:34982025
Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation. PMID:34981765
The diagnostic and prognostic significance of small nuclear ribonucleoprotein Sm D1 aberrantly high expression in hepatocellular carcinoma. PMID:34976182
STXBP6 and B3GNT6 Genes are Associated With Selective IgA Deficiency. PMID:34976003
The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology. PMID:34975914
Breast Cancer Risk with Progestin Subdermal Implants: A Challenge in Patients Counseling. PMID:34975755
An Robust Rank Aggregation and Least Absolute Shrinkage and Selection Operator Analysis of Novel Gene Signatures in Dilated Cardiomyopathy. PMID:34970603
Alpha-2-Macroglobulin in Inflammation, Immunity and Infections. PMID:34970276
Urine proteomics identifies biomarkers for diabetic kidney disease at different stages. PMID:34963468
Inositol Phosphates and Retroviral Assembly: A Cellular Perspective. PMID:34960784
Dynamic, but Not Necessarily Disordered, Human-Virus Interactions Mediated through SLiMs in Viral Proteins. PMID:34960638
Comprehensive Analysis of Myoferlin in Human Pancreatic Cancer via Bioinformatics. PMID:34957301
Cholesterol metabolism: from lipidomics to immunology. PMID:34953867
AHDC1 missense mutations in Xia-Gibbs syndrome. PMID:34950897
HPV16-LINC00393 Integration Alters Local 3D Genome Architecture in Cervical Cancer Cells. PMID:34950609
Identification and Clinical Validation of Key Extracellular Proteins as the Potential Biomarkers in Relapsing-Remitting Multiple Sclerosis. PMID:34950135
Multi-Omics Reveal the Immunological Role and the Theragnostic Value of miR-216a/GDF15 Axis in Human Colon Adenocarcinoma. PMID:34948431
Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer's Disease. PMID:34948414
IRAG2 Interacts with IP3-Receptor Types 1, 2, and 3 and Regulates Intracellular Ca2+ in Murine Pancreatic Acinar Cells. PMID:34948204
NAPRT Expression Regulation Mechanisms: Novel Functions Predicted by a Bioinformatics Approach. PMID:34946971
MiRNA-Regulated Pathways for Hypertrophic Cardiomyopathy: Network-Based Approach to Insight into Pathogenesis. PMID:34946964
SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase. PMID:34944965
Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism. PMID:34944728
SYNE1 Exonic Variant rs9479297 Contributes to Concurrent Hepatocellular and Transitional Cell Carcinoma Double Primary Cancer. PMID:34944636
Reduction of Rapid Proliferating Tumour Cell Lines by Inhibition of the Specific Glycine Transporter GLYT1. PMID:34944586
Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues. PMID:34944551
The Role of Estrogens and Vitamin D in Cardiomyocyte Protection: A Female Perspective. PMID:34944459
Mouse Organ-Specific Proteins and Functions. PMID:34943957
An Insight into GPCR and G-Proteins as Cancer Drivers. PMID:34943797
Large-Scale Tissue Microarray Evaluation Corroborates High Specificity of High-Level Arginase-1 Immunostaining for Hepatocellular Carcinoma. PMID:34943588
Ephrin Receptors (Ephs) Expression in Thymic Epithelial Tumors: Prognostic Implications and Future Therapeutic Approaches. PMID:34943502
Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer. PMID:34943457
mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells. PMID:34943047
Early Pregnancy Exposure to Ambient Air Pollution among Late-Onset Preeclamptic Cases Is Associated with Placental DNA Hypomethylation of Specific Genes and Slower Placental Maturation. PMID:34941772
Evaluation of Placental Alkaline Phosphatase Expression as A Potential Target of Solid Tumors Immunotherapy by Using Gene and Protein Expression Repositories. PMID:34939766
A graphical representation of glycan heterogeneity. PMID:34939082
TNFRSF11B Suppresses Memory CD4+ T Cell Infiltration in the Colon Cancer Microenvironment: A Multiomics Integrative Analysis. PMID:34938284
Rhesus Macaque CODEX Multiplexed Immunohistochemistry Panel for Studying Immune Responses During Ebola Infection. PMID:34938283
Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites. PMID:34934117
Toxoplasma-proximal and distal control by GBPs in human macrophages. PMID:34931666
Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells. PMID:34930929
LDexpress: an online tool for integrating population-specific linkage disequilibrium patterns with tissue-specific expression data. PMID:34930111
Ischemic Heart Disease Selectively Modifies the Right Atrial Appendage Transcriptome. PMID:34926599
Integrative Analysis of MALT1 as a Potential Therapeutic Target for Prostate Cancer and its Immunological Role in Pan-Cancer. PMID:34926571
Prognostic Implications and Immune Infiltration Analysis of ALDOA in Lung Adenocarcinoma. PMID:34925439
EASINESS: E. coli Assisted Speedy affINity-maturation Evolution SyStem. PMID:34925322
Subcellular Transcriptomics and Proteomics: A Comparative Methods Review. PMID:34922010
TBX1 functions as a putative oncogene of breast cancer through promoting cell cycle progression. PMID:34919666
NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis. PMID:34919052
Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume. PMID:34916497
Identification of Key Deregulated RNA-Binding Proteins in Pancreatic Cancer by Meta-Analysis and Prediction of Their Role as Modulators of Oncogenesis. PMID:34912796
Epigenetic loss of heterogeneity from low to high grade localized prostate tumours. PMID:34911933
Misexpression of genes lacking CpG islands drives degenerative changes during aging. PMID:34910517
Potential Novel Modules and Hub Genes as Prognostic Candidates of Thyroid Cancer by Weighted Gene Co-Expression Network Analysis. PMID:34908870
Integrative analysis reveals methylenetetrahydrofolate dehydrogenase 1-like as an independent shared diagnostic and prognostic biomarker in five different human cancers. PMID:34908119
Transcriptomic adaptation during skeletal muscle habituation to eccentric or concentric exercise training. PMID:34907264
IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies. PMID:34906138
Plasma-Derived Extracellular Vesicles Reveal Galectin-3 Binding Protein as Potential Biomarker for Early Detection of Glioma. PMID:34900729
How Times Have Changed! A Cornucopia of Antigens for Membranous Nephropathy. PMID:34899763
Pharmacological Activation of cGAS for Cancer Immunotherapy. PMID:34899704
Pan-Cancer Analysis Reveals the Signature of TMC Family of Genes as a Promising Biomarker for Prognosis and Immunotherapeutic Response. PMID:34899684
Monitoring one-carbon metabolism by mass spectrometry to assess liver function and disease. PMID:34897580
Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation. PMID:34896640
GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus. PMID:34893534
A poly(ethylene glycol) three-dimensional bone marrow hydrogel. PMID:34890973
MLL4 mediates differentiation and tumor suppression through ferroptosis. PMID:34890228
Carboxypeptidase A1 (CPA1) Immunohistochemistry Is Highly Sensitive and Specific for Acinar Cell Carcinoma (ACC) of the Pancreas. PMID:34889867
FAPI-04 Uptake in Healthy Tissues of Cancer Patients in 68Ga-FAPI-04 PET/CT Imaging. PMID:34887714
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus. PMID:34887389
Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity. PMID:34885241
The Role of Arginine Metabolism in Oral Tongue Squamous Cell Carcinoma. PMID:34885177
Renal Safety Profile of EGFR Targeted Therapies: A Study from VigiBase® the WHO Global Database of Individual Case Safety Reports. PMID:34885014
The Extracellular Matrix Environment of Clear Cell Renal Cell Carcinoma Determines Cancer Associated Fibroblast Growth. PMID:34884982
Differential Actions of Muscarinic Receptor Subtypes in Gastric, Pancreatic, and Colon Cancer. PMID:34884958
Fibroblast Activation Protein Targeted Photodynamic Therapy Selectively Kills Activated Skin Fibroblasts from Systemic Sclerosis Patients and Prevents Tissue Contraction. PMID:34884484
Variable expression of eighteen common housekeeping genes in human non-cancerous kidney biopsies. PMID:34882702
Hypomethylation-driven AKT Serine/Threonine Kinase 3 promotes testicular germ cell tumors proliferation and negatively correlates to immune infiltration. PMID:34882061
A convenient test system for the identification of CYP4V2 inhibitors. PMID:34880593
A proteomics study identifying interactors of the FSHD2 gene product SMCHD1 reveals RUVBL1-dependent DUX4 repression. PMID:34880314
Epigenetic Silencing of 15-Hydroxyprostaglandin Dehydrogenase by Histone Methyltransferase EHMT2/G9a in Cholangiocarcinoma. PMID:34880125
Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19. PMID:34878969
Characterization of the GATA Transcription Factor Family and Exploration of Their Relevance to Immune Infiltration and Tumor Microenvironment in Pancreatic Cancer. PMID:34876843
High expression of eIF4E is associated with tumor macrophage infiltration and leads to poor prognosis in breast cancer. PMID:34876062
Altered protein secretion in Batten disease. PMID:34870700
With No Lysine Kinase 1 Promotes Metabolic Derangements and RV Dysfunction in Pulmonary Arterial Hypertension. PMID:34869947
Comprehensive Analysis and Identification of Prognostic Biomarkers and Therapeutic Targets Among FAM83 Family Members for Gastric Cancer. PMID:34869310
RNA-Binding Protein Expression Alters Upon Differentiation of Human B Cells and T Cells. PMID:34867946
Multi-modal Profiling of the Extracellular Matrix of Human Fallopian Tubes and Serous Tubal Intraepithelial Carcinomas. PMID:34866441
Phenome risk classification enables phenotypic imputation and gene discovery in developmental stuttering. PMID:34861174
Facioscapulohumeral dystrophy weakened sarcomeric contractility is mimicked in induced pluripotent stem cells-derived innervated muscle fibres. PMID:34859613
Large-scale integration of the plasma proteome with genetics and disease. PMID:34857953
ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function. PMID:34857875
Cell type-specific analysis by single-cell profiling identifies a stable mammalian tRNA-mRNA interface and increased translation efficiency in neurons. PMID:34857654
Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast. PMID:34849907
A cross-species approach for the identification of Drosophila male sterility genes. PMID:34849808
Expression of human HIPKs in Drosophila demonstrates their shared and unique functions in a developmental model. PMID:34849772
Biallelic inheritance in a single Pakistani family with intellectual disability implicates new candidate gene RDH14. PMID:34848785
LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry in trans. PMID:34845449
Serine catabolism generates liver NADPH and supports hepatic lipogenesis. PMID:34845393
Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation. PMID:34845248
Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms. PMID:34844191
Proteome of the Luminal Surface of the Blood-Brain Barrier. PMID:34842825
Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure. PMID:34842295
Comprehensive gene cluster analysis of head and neck squamous cell carcinoma TCGA RNA-seq data defines B cell immunity-related genes as a robust survival predictor. PMID:34841601
SLC13A4 Might Serve as a Prognostic Biomarker and be Correlated with Immune Infiltration into Head and Neck Squamous Cell Carcinoma. PMID:34840533
Prognostic Value Estimation of BRIP1 in Breast Cancer by Exploiting Transcriptomics Data Through Bioinformatics Approaches. PMID:34840500
Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients. PMID:34839279
Identifying the Predictive Role of Oxidative Stress Genes in the Prognosis of Glioma Patients. PMID:34836934
Protein Aggregation of NPAS3, Implicated in Mental Illness, Is Not Limited to the V304I Mutation. PMID:34834422
Revisiting the Role of GSK3, A Modulator of Innate Immunity, in Idiopathic Inclusion Body Myositis. PMID:34831477
Identification of Cellular Factors Required for SARS-CoV-2 Replication. PMID:34831382
Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer's Disease. PMID:34831245
Diagnostic and Prognostic Implications of Caspase-1 and PD-L1 Co-Expression Patterns in Myelodysplastic Syndromes. PMID:34830867
The Protein Landscape of Mucinous Ovarian Cancer: Towards a Theranostic. PMID:34830751
Chemical Exposures Affect Innate Immune Response to SARS-CoV-2. PMID:34830356
Biochemical Characterisation of Human Transglutaminase 4. PMID:34830327
Molecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development. PMID:34830058
Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma. PMID:34829830
Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies. PMID:34829671
Integration and Visualization of Regulatory Elements and Variations of the EPAS1 Gene in Human. PMID:34828399
Gender-Specific Metabolomics Approach to Kidney Cancer. PMID:34822425
Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer. PMID:34821068
Proteomic profiling identifies signatures associated with progression of precancerous gastric lesions and risk of early gastric cancer. PMID:34818622
Feedback Loop Regulation between Pim Kinases and Tax Keeps Human T-Cell Leukemia Virus Type 1 Viral Replication in Check. PMID:34818069
Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. PMID:34817906
ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis. PMID:34816763
Lymphocyte cytosolic protein 2 is a novel prognostic marker in lung adenocarcinoma. PMID:34816740
Lysosomal dysfunction impairs mitochondrial quality control and is associated with neurodegeneration in TBCK encephaloneuronopathy. PMID:34816123
A proximity proteomics screen in three-dimensional spheroid cultures identifies novel regulators of lumen formation. PMID:34815476
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging. PMID:34811556
Exploring the signaling space of a GPCR using bivalent ligands with a rigid oligoproline backbone. PMID:34810259
Delayed DNA replication in haploid human embryonic stem cells. PMID:34810218
Distinct associations of NEDD4L expression with genetic abnormalities and prognosis in acute myeloid leukemia. PMID:34809620
Whole-exome analysis of adolescents with low VWF and heavy menstrual bleeding identifies novel genetic associations. PMID:34807970
Elucidating the Activation Mechanism of AMPK by Direct Pan-Activator PF-739. PMID:34805275
Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer. PMID:34804118
Comprehensive Analysis of m6A RNA Methylation Regulators and the Immune Microenvironment to Aid Immunotherapy in Pancreatic Cancer. PMID:34804059
Construction of circRNA-miRNA-mRNA network and identification of novel potential biomarkers for non-small cell lung cancer. PMID:34801043
PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer. PMID:34800542
Methionine synthase supports tumour tetrahydrofolate pools. PMID:34799699
A glucagon analogue decreases body weight in mice via signalling in the liver. PMID:34799628
Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. PMID:34798047
Phosphatidylserine receptors enhance SARS-CoV-2 infection. PMID:34797899
Glia Maturation Factor Beta as a Novel Biomarker and Therapeutic Target for Hepatocellular Carcinoma. PMID:34796110
Induction of Anti-Aquaporin 5 Autoantibody Production by Immunization with a Peptide Derived from the Aquaporin of Prevotella melaninogenica Leads to Reduced Salivary Flow in Mice. PMID:34796038
Homozygous duplication identified by whole genome sequencing causes LRBA deficiency. PMID:34795304
Single-Cell, Single-Nucleus, and Spatial RNA Sequencing of the Human Liver Identifies Cholangiocyte and Mesenchymal Heterogeneity. PMID:34792289
A Cholesterol Homeostasis-Related Gene Signature Predicts Prognosis of Endometrial Cancer and Correlates With Immune Infiltration. PMID:34790227
Integrated Analysis of Expression and Prognostic Values of Acyl-CoA Dehydrogenase short-chain in Colorectal Cancer. PMID:34790035
C/EBPZ modulates the differentiation and proliferation of preadipocytes. PMID:34789850
Multidimensional Analysis of the Role of Charged Multivesicular Body Protein 7 in Pan-Cancer. PMID:34785938
ATRX proximal protein associations boast roles beyond histone deposition. PMID:34780483
Controversies surrounding peripheral cannabinoid receptor 1 in fatty liver disease. PMID:34779413
A large-scale transcriptome-wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine-mapping. PMID:34779012
Radioresistance of Human Cancers: Clinical Implications of Genetic Expression Signatures. PMID:34778082
Sodium-Glucose Co-Transporter 2 Inhibitors May Change the Development of Urinary Tract and Hematological Malignancies as Compared With Dipeptidyl Peptidase-4 Inhibitors: Data of the Post-Hoc Analysis of a Nationwide Study. PMID:34778040
Knockdown of Oligosaccharyltransferase Subunit Ribophorin 1 Induces Endoplasmic-Reticulum-Stress-Dependent Cell Apoptosis in Breast Cancer. PMID:34778038
Suprabasin: Role in human cancers and other diseases. PMID:34775572
GCC2 as a New Early Diagnostic Biomarker for Non-Small Cell Lung Cancer. PMID:34771645
Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation. PMID:34769302
Growth of Biological Complexity from Prokaryotes to Hominids Reflected in the Human Genome. PMID:34769071
Infection of Brain Pericytes Underlying Neuropathology of COVID-19 Patients. PMID:34769052
Revealing the Molecular Mechanisms of Alzheimer's Disease Based on Network Analysis. PMID:34768988
An RNA-Seq-Based Framework for Characterizing Canine Prostate Cancer and Prioritizing Clinically Relevant Biomarker Candidate Genes. PMID:34768937
Prognostic biomarkers for predicting papillary thyroid carcinoma patients at high risk using nine genes of apoptotic pathway. PMID:34767591
Severe types of fetopathy are associated with changes in the serological proteome of diabetic mothers. PMID:34766598
Expression of macrophage migration inhibitory factor and its receptor CD74 in systemic sclerosis. PMID:34764810
Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes. PMID:34762911
1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development. PMID:34762852
EZHIP: a new piece of the puzzle towards understanding pediatric posterior fossa ependymoma. PMID:34762160
Model-based assessment of mammalian cell metabolic functionalities using omics data. PMID:34761247
Na+/H+-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer. PMID:34759967
Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis. PMID:34758873
RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. PMID:34758294
AdipoAtlas: A reference lipidome for human white adipose tissue. PMID:34755127
Evolutionary selection of alleles in the melanophilin gene that impacts on prostate organ function and cancer risk. PMID:34754452
Aguascalientes: one of the hottest chronic kidney disease (CKD) hotspots in Mexico and a CKD of unknown aetiology mystery to be solved. PMID:34754425
Cancer drivers and clonal dynamics in acute lymphoblastic leukaemia subtypes. PMID:34753926
BH3-mimetics: recent developments in cancer therapy. PMID:34753495
Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle. PMID:34752468
Anatomical structures, cell types and biomarkers of the Human Reference Atlas. PMID:34750582
The human telomeric proteome during telomere replication. PMID:34747482
NRAS expression is associated with prognosis and tumor immune microenvironment in lung adenocarcinoma. PMID:34746975
Conditions for maintenance of hepatocyte differentiation and function in 3D cultures. PMID:34746700
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients. PMID:34746695
New Insights Into Human Hyaluronidase 4/Chondroitin Sulphate Hydrolase. PMID:34746156
SPTBN2, a New Biomarker of Lung Adenocarcinoma. PMID:34745988
Ral GEF with the PH Domain and SH3 Binding Motif 1 Regulated by Splicing Factor Junction Plakoglobin and Pyrimidine Metabolism Are Prognostic in Uterine Carcinosarcoma. PMID:34745385
The Oncogenic Role and Immune Infiltration for CARM1 Identified by Pancancer Analysis. PMID:34745258
Endoplasmic Reticulum-Based Calcium Dysfunctions in Synucleinopathies. PMID:34744980
Case Report: A False Negative Case of Anti-Yo Paraneoplastic Myelopathy. PMID:34744969
Systematic Review and Bioinformatic Analysis of microRNA Expression in Autism Spectrum Disorder Identifies Pathways Associated With Cancer, Metabolism, Cell Signaling, and Cell Adhesion. PMID:34744804
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders. PMID:34741163
Advances in integrative African genomics. PMID:34740451
Prognostic and Immune-Infiltrate Significance of miR-222-3p and Its Target Genes in Thyroid Cancer. PMID:34737762
A large Canadian cohort provides insights into the genetic architecture of human hair colour. PMID:34737440
COVID-19 and vertical transmission: assessing the expression of ACE2/TMPRSS2 in the human fetus and placenta to assess the risk of SARS-CoV-2 infection. PMID:34735736
Gene4HL: An Integrated Genetic Database for Hearing Loss. PMID:34733322
Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes. PMID:34732801
Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data. PMID:34732773
HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape. PMID:34732735
Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer's disease. PMID:34732252
Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation. PMID:34732054
p53/FBXL20 axis negatively regulates the protein stability of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase. PMID:34731788
Dissecting mammalian spermatogenesis using spatial transcriptomics. PMID:34731600
miR-146a modulates TLR1/2 and 4 induced inflammation and links it with proliferation and lipid production via the indirect regulation of GNG7 in human SZ95 sebocytes. PMID:34728702
Investigations into SCAMP5, a candidate lupus risk gene expressed in plasmacytoid dendritic cells. PMID:34728555
Expression profile of SARS-CoV-2 cellular entry proteins in normal oral mucosa and oral squamous cell carcinoma. PMID:34726347
Elimination of acquired resistance to PD-1 blockade via the concurrent depletion of tumour cells and immunosuppressive cells. PMID:34725506
Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma. PMID:34724892
SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values. PMID:34722629
A Systematic Review of Transcriptional Dysregulation in Huntington's Disease Studied by RNA Sequencing. PMID:34721539
An In-Silico, In-Vitro and In-Vivo Combined Approach to Identify NMNATs as Potential Protein Targets of ProEGCG for Treatment of Endometriosis. PMID:34721014
Path4Drug: Data Science Workflow for Identification of Tissue-Specific Biological Pathways Modulated by Toxic Drugs. PMID:34721010
Biomarkers for gastrointestinal adverse events related to thiopurine therapy. PMID:34720526
Dynamics of urinary and respiratory shedding of Severe acute respiratory syndrome virus 2 (SARS-CoV-2) RNA excludes urine as a relevant source of viral transmission. PMID:34716901
Human semen quality as affected by SARS-CoV-2 infection: An up-to-date review. PMID:34716614
High-throughput and high-efficiency sample preparation for single-cell proteomics using a nested nanowell chip. PMID:34716329
Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer. PMID:34715817
De novo identification of mammalian ciliary motility proteins using cryo-EM. PMID:34715025
A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease. PMID:34712920
CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum. PMID:34711653
SARS-CoV-2-host proteome interactions for antiviral drug discovery. PMID:34709727
Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia. PMID:34709177
Identification of a Prognosis-Related Risk Signature for Bladder Cancer to Predict Survival and Immune Landscapes. PMID:34708131
Analysing a Novel RNA-Binding-Protein-Related Prognostic Signature Highly Expressed in Breast Cancer. PMID:34707800
Non-Invasive Characterization of the Pancreas During Bariatric Surgery via Circulating Pancreatic Specific Cell-free Messenger RNA. PMID:34707641
Multi-Omics Analysis Identified TMED2 as a Shared Potential Biomarker in Six Subtypes of Human Cancer. PMID:34707394
Pathophysiological and diagnostic importance of fatty acid-binding protein 1 in heart failure with preserved ejection fraction. PMID:34707207
Concept and application of circulating proteasomes. PMID:34707192
Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors. PMID:34706560
Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults. PMID:34706549
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference. PMID:34705895
Characterisation of Levonorgestrel-Resistant Endometrial Cancer Cells. PMID:34703309
Bifunctional molecules targeting SARS-CoV-2 spike and the polymeric Ig receptor display neutralization activity and mucosal enrichment. PMID:34693867
Weighted Gene Co-expression Network Analysis Identifies a Cancer-Associated Fibroblast Signature for Predicting Prognosis and Therapeutic Responses in Gastric Cancer. PMID:34692770
Exploring Somatic Alteration Associating With Aggressive Behaviors of Papillary Thyroid Carcinomas by Targeted Sequencing. PMID:34692499
Identification of C3 and FN1 as potential biomarkers associated with progression and prognosis for clear cell renal cell carcinoma. PMID:34688260
NUAK Kinases: Brain-Ovary Axis. PMID:34685740
Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions. PMID:34684847
Cellular Protein Phosphatase 2A Regulates Cell Survival Mechanisms in Influenza A Virus Infection. PMID:34681823
Conserved Structure and Evolution of DPF Domain of PHF10-The Specific Subunit of PBAF Chromatin Remodeling Complex. PMID:34681795
The Heparanase Regulatory Network in Health and Disease. PMID:34681753
Mass Spectrometry-Based Proteomics Reveal Alcohol Dehydrogenase 1B as a Blood Biomarker Candidate to Monitor Acetaminophen-Induced Liver Injury. PMID:34681731
Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas. PMID:34680577
Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases. PMID:34680427
The Clinical and Theranostic Values of Activated Leukocyte Cell Adhesion Molecule (ALCAM)/CD166 in Human Solid Cancers. PMID:34680335
A Unified Transcriptional, Pharmacogenomic, and Gene Dependency Approach to Decipher the Biology, Diagnostic Markers, and Therapeutic Targets Associated with Prostate Cancer Metastasis. PMID:34680307
Probiotics and Trained Immunity. PMID:34680035
Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism. PMID:34678314
Prediction of severe adverse events, modes of action and drug treatments for COVID-19's complications. PMID:34675303
The nomogram based on the 6-lncRNA model can promote the prognosis prediction of patients with breast invasive carcinoma. PMID:34675301
Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases. PMID:34675204
Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome. PMID:34672947
Non-Coding RNA and Frizzled Receptors in Cancer. PMID:34671643
Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity? PMID:34671320
Myoglobin Protects Breast Cancer Cells Due to Its ROS and NO Scavenging Properties. PMID:34671319
COVID-19 disease and malignant cancers: The impact for the furin gene expression in susceptibility to SARS-CoV-2. PMID:34671211
Prognostic role of tumour-infiltrating lymphocytes and macrophages in relation to MSI, CDX2 and BRAF status: a population-based study of metastatic colorectal cancer patients. PMID:34671130
Differentially accessible, single copy sequences form contiguous domains along metaphase chromosomes that are conserved among multiple tissues. PMID:34670606
Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in colorectal cancer. PMID:34670584
Urinary proteomics investigations into contrast-induced acute kidney injury. PMID:34669736
Deciphering the link between Diabetes mellitus and SARS-CoV-2 infection through differential targeting of microRNAs in the human pancreas. PMID:34669152
Extracellular Domains of Transmembrane Proteins Defy the Expression Level-Evolutionary Rate Anticorrelation. PMID:34665250
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19. PMID:34663813
Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy. PMID:34663807
Quantifying full-length circular RNAs in cancer. PMID:34663689
Kappa but not delta or mu opioid receptors form homodimers at low membrane densities. PMID:34657173
Identification and quantification of immune infiltration landscape on therapy and prognosis in left- and right-sided colon cancer. PMID:34657172
Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation. PMID:34656824
Protecting the future: balancing proteostasis for reproduction. PMID:34654604
The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice. PMID:34653361
Urinary extracellular vesicles: Assessment of pre-analytical variables and development of a quality control with focus on transcriptomic biomarker research. PMID:34651466
Notch Intracellular Domain Plasmid Delivery via Poly(Lactic-Co-Glycolic Acid) Nanoparticles to Upregulate Notch Pathway Molecules. PMID:34651022
Identification of FAM107A as a potential biomarker and therapeutic target for prostate carcinoma. PMID:34650688
Meta-Analysis illustrates possible role of lipopolysaccharide (LPS)-induced tissue injury in nasopharyngeal carcinoma (NPC) pathogenesis. PMID:34648530
OncomiRs miR-106a and miR-17 negatively regulate the nucleoside-derived drug transporter hCNT1. PMID:34647142
Case Report: A Novel GNB1 Mutation Causes Global Developmental Delay With Intellectual Disability and Behavioral Disorders. PMID:34646230
Discovery of alternatively spliced isoforms and long non-coding RNA in full length brain transcriptomes of anadromous Hilsa shad, Tenualosa ilisha (Hamilton, 1822). PMID:34643921
hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage. PMID:34642383
Tissue Sampling and Homogenization in the Sub-Microliter Scale with a Nanosecond Infrared Laser (NIRL) for Mass Spectrometric Proteomics. PMID:34639174
The Distinct Properties of the Consecutive Disordered Regions Inside or Outside Protein Domains and Their Functional Significance. PMID:34639018
Molecular Insights into SARS-CoV2-Induced Alterations of the Gut/Brain Axis. PMID:34638785
Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation. PMID:34638511
Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity. PMID:34638503
Challenges and Prospects for Designer T and NK Cells in Glioblastoma Immunotherapy. PMID:34638471
Proteomic Landscape of Prostate Cancer: The View Provided by Quantitative Proteomics, Integrative Analyses, and Protein Interactomes. PMID:34638309
Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma. PMID:34638286
High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma. PMID:34635011
A metabolism-relevant signature as a predictor for prognosis and therapeutic response in pancreatic cancer. PMID:34632851
OnTheFly2.0: a text-mining web application for automated biomedical entity recognition, document annotation, network and functional enrichment analysis. PMID:34632381
Identification and Characterisation of cis-Regulatory Elements Upstream of the Human Receptor Tyrosine Kinase Gene MERTK. PMID:34631417
Promising Epigenetic Biomarkers Associated With Cancer-Associated-Fibroblasts for Progression of Kidney Renal Clear Cell Carcinoma. PMID:34630525
Chip Protein U-Box Domain Truncation Affects Purkinje Neuron Morphology and Leads to Behavioral Changes in Zebrafish. PMID:34630034
Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer. PMID:34628286
Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways. PMID:34624527
Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma. PMID:34621750
Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection. PMID:34621686
mRNA Network: Solution for Tracking Chemotherapy Insensitivity in Small-Cell Lung Cancer. PMID:34621500
Testicular Nuclear Receptor 4 Regulates Proliferation and Apoptosis of Bladder Cancer via Bcl-2. PMID:34616769
Novel ACE2 protein interactions relevant to COVID-19 predicted by evolutionary rate correlations. PMID:34616619
CTHRC1 expression is a novel shared diagnostic and prognostic biomarker of survival in six different human cancer subtypes. PMID:34615943
EZH2 knockout in oral cavity basal epithelia causes more invasive squamous cell carcinomas. PMID:34614148
Low expression of endoplasmic reticulum stress-related gene SERP1 is associated with poor prognosis and immune infiltration in skin cutaneous melanoma. PMID:34613934
Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells. PMID:34611477
Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma. PMID:34607313
PeptiCHIP: A Microfluidic Platform for Tumor Antigen Landscape Identification. PMID:34605646
Cancer chemoprevention through Frizzled receptors and EMT. PMID:34604862
SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma. PMID:34604392
PDZ Binding Kinase/T-LAK Cell-Derived Protein Kinase Plays an Oncogenic Role and Promotes Immune Escape in Human Tumors. PMID:34603451
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity. PMID:34599178
ATP-binding cassette transporters mediate differential biosynthesis of glycosphingolipid species. PMID:34597626
Dissecting Genomic Determinants of Positive Selection with an Evolution-Guided Regression Model. PMID:34597406
MBOAT1 homozygous missense variant causes nonobstructive azoospermia. PMID:34596601
circRPS16 Promotes Proliferation and Invasion of Hepatocellular Carcinoma by Sponging miR-876-5p to Upregulate SPINK1. PMID:34595116
Bioinformatics Analyses Reveal the Prognostic Value and Biological Roles of SEPHS2 in Various Cancers. PMID:34594130
Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia. PMID:34589087
Suppressor effect of catechol-O-methyltransferase gene in prostate cancer. PMID:34587154
Impact of depression and stress on placental DNA methylation in ethnically diverse pregnant women. PMID:34585950
UBE2S activates NF-κB signaling by binding with IκBα and promotes metastasis of lung adenocarcinoma cells. PMID:34582005
Enrichment of SARS-CoV-2 Entry Factors and Interacting Intracellular Genes in Tissue and Circulating Immune Cells. PMID:34578338
Cell Models for Chromosome 20q11.21 Amplification and Drug Sensitivities in Colorectal Cancer. PMID:34577783
Catenin Alpha 2 May Be a Biomarker or Potential Drug Target in Psychiatric Disorders with Perseverative Negative Thinking. PMID:34577549
LRP1B: A Giant Lost in Cancer Translation. PMID:34577535
The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes. PMID:34577099
Analysis of Molecular Networks in the Cerebellum in Chronic Schizophrenia: Modulation by Early Postnatal Life Stressors in Murine Models. PMID:34576238
Genomic and Ancestral Variation Underlies the Severity of COVID-19 Clinical Manifestation in Individuals of European Descent. PMID:34575070
The Phenotypic Spectrum of Patients with PHARC Syndrome Due to Variants in ABHD12: An Ophthalmic Perspective. PMID:34573385
Identifying Plectin Isoform Functions through Animal Models. PMID:34572100
Artificial Intelligence-Assisted Identification of Genetic Factors Predisposing High-Risk Individuals to Asymptomatic Heart Failure. PMID:34572079
Potential Therapeutic Effect of Micrornas in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2. PMID:34572043
Comprehensive Characterization of Multitissue Expression Landscape, Co-Expression Networks and Positive Selection in Pikeperch. PMID:34571938
Distinct gene-set burden patterns underlie common generalized and focal epilepsies. PMID:34571366
Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome. PMID:34570756
miRNATissueAtlas2: an update to the human miRNA tissue atlas. PMID:34570238
Construction of circRNA-based ceRNA network and its prognosis-associated subnet of clear cell renal cell carcinoma. PMID:34569727
Chromobox Homolog 8 (CBX8) in Human Tumor Carcinogenesis and Prognosis: A Pancancer Analysis Using Multiple Databases. PMID:34567093
Renal Lipid Metabolism Abnormalities in Obesity and Clear Cell Renal Cell Carcinoma. PMID:34564424
CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner. PMID:34563205
Mitogen-activated protein kinase-activated protein kinase-2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer. PMID:34559922
Antimicrobial protein REG3A and signaling networks are predictive of stroke outcomes. PMID:34558059
Early Leukocyte Responses in Ex-Vivo Models of Healing and Non-Healing Human Leishmania (Viannia) panamensis Infections. PMID:34557423
Expression and prognosis of CDC45 in cervical cancer based on the GEO database. PMID:34557356
SOX10 Knockdown Inhibits Melanoma Cell Proliferation via Notch Signaling Pathway. PMID:34557039
Path to improving the life cycle and quality of genome-scale models of metabolism. PMID:34555324
Pan-cancer proteogenomic investigations identify post-transcriptional kinase targets. PMID:34552204
Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoids. PMID:34548904
Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease. PMID:34548398
Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases. PMID:34548389
Sex Differences in the Role of CNIH3 on Spatial Memory and Synaptic Plasticity. PMID:34548146
Adipose tissue dysfunction and MAFLD in obesity on the scene of COVID-19. PMID:34543756
A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms. PMID:34541665
Association between the expression of core 3 synthase and survival outcomes of patients with cholangiocarcinoma. PMID:34539864
A Comprehensive Multiomics Analysis Identified Ubiquilin 4 as a Promising Prognostic Biomarker of Immune-Related Therapy in Pan-Cancer. PMID:34539785
Physical and Functional Interaction of Mitochondrial Single-Stranded DNA-Binding Protein and the Catalytic Subunit of DNA Polymerase Gamma. PMID:34539752
Impact of vitamin C supplementation on placental DNA methylation changes related to maternal smoking: association with gene expression and respiratory outcomes. PMID:34538263
Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers. PMID:34535764
DDX3X and DDX3Y are redundant in protein synthesis. PMID:34535544
Plasma fibulin-1 levels during pregnancy and delivery: a longitudinal observational study. PMID:34535108
Hepatic Regulator of G Protein Signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death. PMID:34534913
Proteogenomic characterization of pancreatic ductal adenocarcinoma. PMID:34534465
Acute Decompensated Heart Failure and the Kidney: Physiological, Histological and Transcriptomic Responses to Development and Recovery. PMID:34533033
Identifying the dynamic gene regulatory network during latent HIV-1 reactivation using high-dimensional ordinary differential equations. PMID:34531927
Multidimensional Analyses of Tumor Immune Microenvironment Reveal the Possible Rationality of Immunotherapy and Identify High Immunotherapy Response Subtypes for Renal Papillary Cell Carcinoma. PMID:34531849
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. PMID:34530870
Comparison of Multiple Clinical Testing Modalities for Assessment of NPM1-Mutant AML. PMID:34527579
The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson's Disease and Their Association With Disease State and Clinical Features. PMID:34526889
NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions. PMID:34525352
Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs. PMID:34520530
Affinity-based profiling of endogenous phosphoprotein phosphatases by mass spectrometry. PMID:34518704
DPYSL2 as potential diagnostic and prognostic biomarker linked to immune infiltration in lung adenocarcinoma. PMID:34517904
Platelets amplify endotheliopathy in COVID-19. PMID:34516880
Contraceptive and Infertility Target DataBase: a contraceptive drug development tool for targeting and analysis of human reproductive specific tissues†. PMID:34514504
Integrative Epigenome Map of the Normal Human Prostate Provides Insights Into Prostate Cancer Predisposition. PMID:34513844
A Multiplex Thyroid-Specific Assay for Quantification of Circulating Thyroid Cell-Free RNA in Plasma of Thyroid Cancer Patients. PMID:34512731
Cross-Species and Human Inter-Tissue Network Analysis of Genes Implicated in Longevity and Aging Reveal Strong Support for Nutrient Sensing. PMID:34512728
ESPL1 Is a Novel Prognostic Biomarker Associated With the Malignant Features of Glioma. PMID:34512713
Comprehensive Analysis of the Expression and Prognosis for Laminin Genes in Ovarian Cancer. PMID:34512203
Stem/Proliferative and Differentiated Cells within Primary Murine Colonic Epithelium Display Distinct Intracellular Free Ca2+ Signal Codes. PMID:34510822
SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pathway. PMID:34509929
In silico exploration of enzymes involved in sialic acid biosynthesis and their possible role in SARS-CoV-2 infection. PMID:34506921
Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia. PMID:34504651
The Cancer Epitope Database and Analysis Resource: A Blueprint for the Establishment of a New Bioinformatics Resource for Use by the Cancer Immunology Community. PMID:34504503
Defining the Tumor Microenvironment by Integration of Immunohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry. PMID:34503228
Landscape of Bone Marrow Metastasis in Human Neuroblastoma Unraveled by Transcriptomics and Deep Multiplex Imaging. PMID:34503120
Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43266-283 in Glioblastoma Stem Cells. PMID:34503072
Tau Protein Interaction Partners and Their Roles in Alzheimer's Disease and Other Tauopathies. PMID:34502116
Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β. PMID:34499926
A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships. PMID:34498060
Evaluation of the Oncogene Function of GOLPH3 and Correlated Regulatory Network in Lung Adenocarcinoma. PMID:34497755
Cells of the human intestinal tract mapped across space and time. PMID:34497389
Nonredundant, isoform-specific roles of HDAC1 in glioma stem cells. PMID:34494550
Reconstruction of the Cytokine Signaling in Lysosomal Storage Diseases by Literature Mining and Network Analysis. PMID:34490253
Identification of the Real Hub Gene and Construction of a Novel Prognostic Signature for Pancreatic Adenocarcinoma Based on the Weighted Gene Co-expression Network Analysis and Least Absolute Shrinkage and Selection Operator Algorithms. PMID:34490033
Serum Anti-PDLIM1 Autoantibody as Diagnostic Marker in Ovarian Cancer. PMID:34489945
Prognostic role of EGR1 in breast cancer: a systematic review. PMID:34488929
Protein degradation technology: a strategic paradigm shift in drug discovery. PMID:34488823
Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids. PMID:34487490
A pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers. PMID:34486492
Sour Taste SNP KCNJ2-rs236514 and Differences in Nutrient Intakes and Metabolic Health Markers in the Elderly. PMID:34485363
Adenine base editing of the DUX4 polyadenylation signal for targeted genetic therapy in facioscapulohumeral muscular dystrophy. PMID:34484861
A Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide. PMID:34481949
Genome-Wide Phylogenetic Analysis, Expression Pattern, and Transcriptional Regulatory Network of the Pig C/EBP Gene Family. PMID:34471342
ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity. PMID:34471224
Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia. PMID:34471128
De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity. PMID:34470666
Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression. PMID:34467243
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study. PMID:34465810
Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice. PMID:34462439
GSK2126458 has the potential to inhibit the proliferation of pancreatic cancer uncovered by bioinformatics analysis and pharmacological experiments. PMID:34461940
A multi-objective genetic algorithm to find active modules in multiplex biological networks. PMID:34460810
TIAMMAt: Leveraging Biodiversity to Revise Protein Domain Models, Evidence from Innate Immunity. PMID:34459919
High mRNA Expression of CENPL and Its Significance in Prognosis of Hepatocellular Carcinoma Patients. PMID:34457090
Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson-Gilford Progeria syndrome. PMID:34453483
Proteomic discovery of non-invasive biomarkers of localized prostate cancer using mass spectrometry. PMID:34453155
The Cysteine-Containing Cell-Penetrating Peptide AP Enables Efficient Macromolecule Delivery to T Cells and Controls Autoimmune Encephalomyelitis. PMID:34452095
Selective Moonlighting Cell-Penetrating Peptides. PMID:34452080
Variable Distribution of DOCK-D Proteins between Cytosol and Nucleoplasm in Cell Lines, Effect of Interleukin-4 on DOCK10 in B-Cell Lymphoid Neoplasms, and Validation of a New DOCK10 Antiserum for Immunofluorescence Studies. PMID:34449554
Special Considerations in the Management of Autoimmune Hepatitis in COVID-19 Hotspots: A Review. PMID:34447687
CEACAM Gene Family Mutations Associated With Inherited Breast Cancer Risk - A Comparative Oncology Approach to Discovery. PMID:34447411
Role of β-Adrenergic Receptors and Estrogen in Cardiac Repair after Myocardial Infarction: An Overview. PMID:34445662
Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis. PMID:34445502
Investigation of LINC00493/SMIM26 Gene Suggests Its Dual Functioning at mRNA and Protein Level. PMID:34445188
The Histone Variant MacroH2A1 Impacts Circadian Gene Expression and Cell Phenotype in an In Vitro Model of Hepatocellular Carcinoma. PMID:34440260
Survival-Based Biomarker Module Identification Associated with Oral Squamous Cell Carcinoma (OSCC). PMID:34439992
Profiling Human CD55 Transgene Performance Assist in Selecting Best Suited Specimens and Tissues for Swine Organ Xenotransplantation. PMID:34439979
Cell Adhesion Molecules in Normal Skin and Melanoma. PMID:34439879
Impact of EcSOD Perturbations in Cancer Progression. PMID:34439467
Molecular Changes Induced in Melanoma by Cell Culturing in 3D Alginate Hydrogels. PMID:34439267
An Adverse Outcomes Approach to Study the Effects of SARS-CoV-2 in 3D Organoid Models. PMID:34437890
Bothrops Jararaca Snake Venom Modulates Key Cancer-Related Proteins in Breast Tumor Cell Lines. PMID:34437390
The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children. PMID:34437303
Rush Hour of LATs towards Their Transport Cycle. PMID:34436365
Lipid Transporters Beam Signals from Cell Membranes. PMID:34436325
Distinct contributions of meprins to skin regeneration after injury - Meprin α a physiological processer of pro-collagen VII. PMID:34435182
COVID-19 infection and liver injury: Clinical features, biomarkers, potential mechanisms, treatment, and management challenges. PMID:34434987
Identification of a Costimulatory Molecule Gene Signature to Predict Survival and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma. PMID:34434928
Identification of a circRNA-miRNA-mRNA regulatory network for exploring novel therapeutic options for glioma. PMID:34434651
Transcriptome Atlas of 16 Donkey Tissues. PMID:34434218
Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry. PMID:34431042
SCD1, autophagy and cancer: implications for therapy. PMID:34429143
What can the neurological manifestations of COVID-19 tell us: a meta-analysis. PMID:34425827
DeepHistoClass: A Novel Strategy for Confident Classification of Immunohistochemistry Images Using Deep Learning. PMID:34425263
Arginase-1 and P-glycoprotein are downregulated in canine hepatocellular carcinoma. PMID:34423599
CD86 Molecule Might Be a Novel Immune-Related Prognostic Biomarker for Patients With Bladder Cancer by Bioinformatics and Experimental Assays. PMID:34422632
Identification of Candidate Biomarkers and Prognostic Analysis in Colorectal Cancer Liver Metastases. PMID:34422629
Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes. PMID:34419158
The relationship between transforming growth factor β superfamily members (GDF11 and BMP4) and lumbar spine bone mineral density in postmenopausal Chinese women. PMID:34417839
Characteristic of molecular subtypes in lung adenocarcinoma based on m6A RNA methylation modification and immune microenvironment. PMID:34416861
Backbone and nearly complete side-chain chemical shift assignments reveal the human uncharacterized protein CXorf51A as intrinsically disordered. PMID:34415548
Biallelic PI4KA variants cause neurological, intestinal and immunological disease. PMID:34415310
Roles of α‑synuclein in gastrointestinal microbiome dysbiosis‑related Parkinson's disease progression (Review). PMID:34414447
DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma. PMID:34414037
TET2 as a tumor suppressor and therapeutic target in T-cell acute lymphoblastic leukemia. PMID:34413196
Screening of DNA Damage Repair Genes Involved in the Prognosis of Triple-Negative Breast Cancer Patients Based on Bioinformatics. PMID:34408776
Targeting AXL in NSCLC. PMID:34408519
Survival analysis in breast cancer using proteomic data from four independent datasets. PMID:34408238
Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids. PMID:34407934
Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease. PMID:34406858
A Diazirine-Modified Membrane Lipid to Study Peptide/Lipid Interactions - Chances and Challenges. PMID:34406694
Diagnosis and prognostic value of C-X-C motif chemokine ligand 1 in colon adenocarcinoma based on The Cancer Genome Atlas and Guangxi cohort. PMID:34405013
TMEM16F and dynamins control expansive plasma membrane reservoirs. PMID:34404808
ZNF768 links oncogenic RAS to cellular senescence. PMID:34404770
Bioinformatics analysis of the transcriptional expression of minichromosome maintenance proteins as potential indicators of survival in patients with cervical cancer. PMID:34404366
Immunopeptidomics toolkit library (IPTK): a python-based modular toolbox for analyzing immunopeptidomics data. PMID:34404349
ZSWIM7 Is Associated With Human Female Meiosis and Familial Primary Ovarian Insufficiency. PMID:34402903
Identification of prognostic and bone metastatic alternative splicing signatures in bladder cancer. PMID:34402716
SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release. PMID:34401873
Cell type-selective targeted delivery of a recombinant lysosomal enzyme for enzyme therapies. PMID:34400331
Comprehensive Analysis of CD163 as a Prognostic Biomarker and Associated with Immune Infiltration in Glioblastoma Multiforme. PMID:34395626
Identification of a Gene Set Correlated With Immune Status in Ovarian Cancer by Transcriptome-Wide Data Mining. PMID:34395521
Proteomic analysis reveals some common proteins in the kidney stone matrix. PMID:34395096
Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples. PMID:34392148
Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias: genetics in inguinal hernias. PMID:34392144
Production of 11-Oxygenated Androgens by Testicular Adrenal Rest Tumors. PMID:34390337
Patients with PWS and related syndromes display differentially methylated regions involved in neurodevelopmental and nutritional trajectory. PMID:34389046
NBAS Variants Are Associated with Quantitative and Qualitative NK and B Cell Deficiency. PMID:34386911
MEF2C Common Genetic Variation Is Associated With Different Aspects of Cognition in Non-Hispanic White and Caribbean Hispanic Non-demented Older Adults. PMID:34386032
Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions. PMID:34385445
The role of basement membranes in cardiac biology and disease. PMID:34382650
Use of a neuron-glia genome-scale metabolic reconstruction to model the metabolic consequences of the Arylsulphatase a deficiency through a systems biology approach. PMID:34381909
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer. PMID:34381029
Cell therapy strategies for COVID-19: Current approaches and potential applications. PMID:34380619
Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer. PMID:34378678
Phase Ib study of patients with metastatic castrate-resistant prostate cancer treated with different sequencing regimens of atezolizumab and sipuleucel-T. PMID:34376554
The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells. PMID:34374812
Emerging protein degradation strategies: expanding the scope to extracellular and membrane proteins. PMID:34373745
Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19. PMID:34372575
Glutamate receptor, ionotropic, N‑methyl D‑aspartate‑associated protein 1 promotes colorectal cancer cell proliferation and metastasis, and is negatively regulated by miR‑296‑3p. PMID:34368871
DeepFeature: feature selection in nonimage data using convolutional neural network. PMID:34368836
Shared genomic segment analysis in a large high-risk chronic lymphocytic leukemia pedigree implicates CXCR4 in inherited risk. PMID:34368645
Identification and Validation of PIK3CA as a Marker Associated with Prognosis and Immune Infiltration in Renal Clear Cell Carcinoma. PMID:34367282
Netrin-1 in Glioblastoma Neovascularization: The New Partner in Crime? PMID:34361013
SARS-CoV-2 Infected Pediatric Cerebral Cortical Neurons: Transcriptomic Analysis and Potential Role of Toll-like Receptors in Pathogenesis. PMID:34360824
The Interactome of the VAP Family of Proteins: An Overview. PMID:34359948
TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions. PMID:34359920
The Role of DND1 in Cancers. PMID:34359581
Dysregulation of PI3K/Akt/PTEN Pathway in Canine Mammary Tumor. PMID:34359206
Basic principles of hydrogel-based tissue transformation technologies and their applications. PMID:34358468
Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification. PMID:34358453
Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines. PMID:34358150
No Evidence for the Involvement of Leiomodin-1 Antibodies in the Pathogenesis of Onchocerciasis-Associated Epilepsy. PMID:34357995
Structure, Activity and Function of the Suv39h1 and Suv39h2 Protein Lysine Methyltransferases. PMID:34357075
Battle Royale: Innate Recognition of Poxviruses and Viral Immune Evasion. PMID:34356829
Loss of the MAF Transcription Factor in Laryngeal Squamous Cell Carcinoma. PMID:34356658
FLAME: A Web Tool for Functional and Literature Enrichment Analysis of Multiple Gene Lists. PMID:34356520
Biosynthesis, Quantification and Genetic Diseases of the Smallest Signaling Thiol Metabolite: Hydrogen Sulfide. PMID:34356298
Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations. PMID:34356065
Pipelines and Systems for Threshold-Avoiding Quantification of LC-MS/MS Data. PMID:34355890
Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent. PMID:34354587
An Immune-Related Gene-Based Signature as Prognostic Tool in Ovarian Serous Cystadenocarcinoma. PMID:34354370
Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids. PMID:34354063
Precision genetic cellular models identify therapies protective against ER stress. PMID:34354042
The RNA-binding protein and stress granule component ATAXIN-2 is expressed in mouse and human tissues associated with glaucoma pathogenesis. PMID:34350994
Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease. PMID:34350953
Directed differentiation of human pluripotent stem cells into epidermal stem and progenitor cells. PMID:34350551
Characterization of Five Transmembrane Proteins: With Focus on the Tweety, Sideroflexin, and YIP1 Domain Families. PMID:34350187
The Impact of the COVID-19 Pandemic on Dementia Risk: Potential Pathways to Cognitive Decline. PMID:34348321
Prognostic Impact of MITD1 and Associates With Immune Infiltration in Kidney Renal Clear Cell Carcinoma. PMID:34346239
In silico assessment of EpCAM transcriptional expression and determination of the prognostic biomarker for human lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). PMID:34345719
Comprehensive analysis of the expression and prognosis for TNFAIPs in head and neck cancer. PMID:34344926
Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders. PMID:34344888
Identification and integrative analysis of ACLY and related gene panels associated with immune microenvironment reveal prognostic significance in hepatocellular carcinoma. PMID:34344378
Semper's cells in the insect compound eye: Insights into ocular form and function. PMID:34343526
A Potential miRNA-mRNA Network for Dementia and Hernia Crosstalk. PMID:34341761
Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells. PMID:34339458
CDH12 as a Candidate Gene for Kidney Injury in Posterior Urethral Valve Cases: A Genome-wide Association Study Among Patients with Obstructive Uropathies. PMID:34337522
Genetic syndromes with vascular malformations - update on molecular background and diagnostics. PMID:34336026
Mapping Autoantibodies in Children With Acute Rheumatic Fever. PMID:34335616
Role of Hydrogen Sulfide in the Endocrine System. PMID:34335475
Cardiovascular Effects Mediated by HMMR and CD44. PMID:34335086
Nucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma. PMID:34334108
Vitamin D supplementation in people with IBS has no effect on symptom severity and quality of life: results of a randomised controlled trial. PMID:34328539
Genome wide DNA methylation analysis of alveolar capillary dysplasia lung tissue reveals aberrant methylation of genes involved in development including the FOXF1 locus. PMID:34325731
DNA methylation differences in cortical grey and white matter in schizophrenia. PMID:34323598
The application of cytokeratin-18 as a biomarker for drug-induced liver injury. PMID:34322741
Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V. PMID:34322157
Exploiting Single-Cell Tools in Gene and Cell Therapy. PMID:34322133
A single-cell type transcriptomics map of human tissues. PMID:34321199
Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma. PMID:34320917
Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis. PMID:34320216
The Src-family Kinase Lyn in Immunoreceptor Signaling. PMID:34320188
The Indirect Antiviral Potential of Long Noncoding RNAs Encoded by IFITM Pseudogenes. PMID:34319781
Toward Comprehensive Plasma Proteomics by Orthogonal Protease Digestion. PMID:34319755
Functionathon: a manual data mining workflow to generate functional hypotheses for uncharacterized human proteins and its application by undergraduate students. PMID:34318869
A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis. PMID:34318286
Reboot: a straightforward approach to identify genes and splicing isoforms associated with cancer patient prognosis. PMID:34316711
Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond. PMID:34316690
SRSF10: an atypical splicing regulator with critical roles in stress response, organ development, and viral replication. PMID:34315816
Chalcone-Supported Cardiac Mesoderm Induction in Human Pluripotent Stem Cells for Heart Muscle Engineering. PMID:34309224
Guillain-Barré syndrome associated with Covid-19: A close relationship or just a coincidence? (Review). PMID:34306190
Study on HOXBs of Clear Cell Renal Cell Carcinoma and Detection of New Molecular Target. PMID:34306077
Circadian Genes as Exploratory Biomarkers in DMD: Results From Both the mdx Mouse Model and Patients. PMID:34305639
Ligand-directed bias of G protein signaling at the dopamine D2 receptor. PMID:34302750
The clinical importance of tandem exon duplication-derived substitutions. PMID:34302486
YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion. PMID:34301937
Knock-Out of ACBD3 Leads to Dispersed Golgi Structure, but Unaffected Mitochondrial Functions in HEK293 and HeLa Cells. PMID:34298889
Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking. PMID:34297830
Web tools to perform long non-coding RNAs analysis in oncology research. PMID:34296748
NEK7 Promotes Pancreatic Cancer Progression And Its Expression Is Correlated With Poor Prognosis. PMID:34295827
Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression. PMID:34294073
Powerful detection of polygenic selection and evidence of environmental adaptation in US beef cattle. PMID:34292938
ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease. PMID:34290711
Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression. PMID:34290087
Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinoma. PMID:34290079
Early intrahepatic duct defects in a cystic fibrosis porcine model. PMID:34288572
Abnormal Liver Biochemistry Tests and Acute Liver Injury in COVID-19 Patients: Current Evidence and Potential Pathogenesis. PMID:34287285
WNT8B as an Independent Prognostic Marker for Nasopharyngeal Carcinoma. PMID:34287269
Altered expression of genes controlling metabolism characterizes the tissue response to immune injury in lupus. PMID:34285256
Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer. PMID:34285249
The role of FOSL1 in stem-like cell reprogramming processes. PMID:34282187
Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin. PMID:34282151
Functional annotation of noncoding mutations in cancer. PMID:34282050
The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition). PMID:34277994
PLXNC1: A Novel Potential Immune-Related Target for Stomach Adenocarcinoma. PMID:34277610
RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in Macrophages via Regulating Histone H3K4 Trimethylation. PMID:34276666
Novel urine biomarkers to distinguish UTI from culture-negative pyuria. PMID:34272611
Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma. PMID:34272452
Prioritizing and characterizing functionally relevant genes across human tissues. PMID:34270548
Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects. PMID:34267199
CK2-mediated phosphorylation of Che-1/AATF is required for its pro-proliferative activity. PMID:34266450
Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2. PMID:34265358
Metastatic heterogeneity of the consensus molecular subtypes of colorectal cancer. PMID:34262039
CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression. PMID:34262017
Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples. PMID:34261731
Expression of Transcription Factor CREM in Human Tissues. PMID:34261344
Identification of Potential Biomarkers From Hepatocellular Carcinoma With MT1 Deletion. PMID:34257549
From Flatland to Jupiter: Searching for Rules of Interaction Across Biological Scales. PMID:34254127
The role of genetic polymorphisms in endolysosomal ion channels TPC2 and P2RX4 in cancer pathogenesis, prognosis, and diagnosis: a genetic association in the UK Biobank. PMID:34253731
Telomere-to-telomere assembly of a fish Y chromosome reveals the origin of a young sex chromosome pair. PMID:34253240
Characterization of a member of the CEACAM protein family as a novel marker of proton pump-rich ionocytes on the zebrafish epidermis. PMID:34252160
A novel high-throughput screen for identifying lipids that stabilise membrane proteins in detergent based solution. PMID:34252116
Urethral Catheter Biofilms Reveal Plasticity in Bacterial Composition and Metabolism and Withstand Host Immune Defenses in Hypoxic Environment. PMID:34249966
Identification of an Metabolic Related Risk Signature Predicts Prognosis in Cervical Cancer and Correlates With Immune Infiltration. PMID:34249930
Role of NRP1 in Bladder Cancer Pathogenesis and Progression. PMID:34249735
Glycolysis-Related Gene Expression Profiling Screen for Prognostic Risk Signature of Pancreatic Ductal Adenocarcinoma. PMID:34249078
ANANSE: an enhancer network-based computational approach for predicting key transcription factors in cell fate determination. PMID:34244796
Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement. PMID:34242919
SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes. PMID:34241597
Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip. PMID:34239116
Protein Secretion Prediction Tools and Extracellular Vesicles Databases. PMID:34236664
Deciphering Network Crosstalk: The Current Status and Potential of miRNA Regulatory Networks on the HSP40 Molecular Chaperone Network. PMID:34234816
An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism. PMID:34234248
NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. PMID:34233163
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma. PMID:34231338
GNRH1 and LTB4R might be novel immune-related prognostic biomarkers in clear cell renal cell carcinoma (ccRCC). PMID:34229684
Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells. PMID:34227245
Chromatin states shaped by an epigenetic code confer regenerative potential to the mouse liver. PMID:34226551
Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment. PMID:34221871
The N-Formyl Peptide Receptors and Rheumatoid Arthritis: A Dangerous Liaison or Confusing Relationship? PMID:34220836
The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019. PMID:34217339
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour. PMID:34211149
VECTOR: An Integrated Correlation Network Database for the Identification of CeRNA Axes in Uveal Melanoma. PMID:34210067
AKT Signaling Modifies the Balance between Cell Proliferation and Migration in Neural Crest Cells from Patients Affected with Bosma Arhinia and Microphthalmia Syndrome. PMID:34209568
Identification of Potential Biomarkers and Biological Pathways for Poor Clinical Outcome in Mucinous Colorectal Adenocarcinoma. PMID:34208938
NOX2 Activation in COVID-19: Possible Implications for Neurodegenerative Diseases. PMID:34208136
SRPassing Co-translational Targeting: The Role of the Signal Recognition Particle in Protein Targeting and mRNA Protection. PMID:34208095
The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout-An Update. PMID:34206432
Exploring the Metabolic Heterogeneity of Cancers: A Benchmark Study of Context-Specific Models. PMID:34205912
Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and Increases the Prevalence of Morphologically Abnormal Spermatozoa. PMID:34205849
Nectin-1 Expression Correlates with the Susceptibility of Malignant Melanoma to Oncolytic Herpes Simplex Virus In Vitro and In Vivo. PMID:34205379
Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity. PMID:34205207
Targeted Treatment of Head and Neck (Pre)Cancer: Preclinical Target Identification and Development of Novel Therapeutic Applications. PMID:34204886
A Conceptual Framework for Integrating Cellular Protein Folding, Misfolding and Aggregation. PMID:34202456
RGS14 Regulation of Post-Synaptic Signaling and Spine Plasticity in Brain. PMID:34201943
Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein. PMID:34201556
Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential. PMID:34201472
The Antimicrobial Activity of Peripheral Blood Neutrophils Is Altered in Patients with Primary Ciliary Dyskinesia. PMID:34201048
Systematic Review of Pharmacogenetic Factors That Influence High-Dose Methotrexate Pharmacokinetics in Pediatric Malignancies. PMID:34200242
The Diagnostic Journey of a Patient with Prader-Willi-Like Syndrome and a Unique Homozygous SNURF-SNRPN Variant; Bio-Molecular Analysis and Review of the Literature. PMID:34200226
Genome-Wide Differential Methylation Profiles from Two Terpene-Rich Medicinal Plant Extracts Administered in Osteoarthritis Rats. PMID:34199631
Elucidating the Mechanism of Action of the Attributed Immunomodulatory Role of Eltrombopag in Primary Immune Thrombocytopenia: An In Silico Approach. PMID:34199099
Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25. PMID:34198503
Passive transfer of fibromyalgia symptoms from patients to mice. PMID:34196305
SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes. PMID:34196300
Structural basis of the selective activation of enzyme isoforms: Allosteric response to activators of β1- and β2-containing AMPK complexes. PMID:34194666
TGM4: an immunogenic prostate-restricted antigen. PMID:34193566
A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity. PMID:34192532
Shaping Up Mitochondria in Diabetic Nephropathy. PMID:34189465
Non-permissive SARS-CoV-2 infection in human neurospheres. PMID:34186311
Targeting neuropilins as a viable SARS-CoV-2 treatment. PMID:34185437
Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study. PMID:34180758
A Comprehensive Analysis of the Downregulation of miRNA-1827 and Its Prognostic Significance by Targeting SPTBN2 and BCL2L1 in Ovarian Cancer. PMID:34179092
SARS-CoV-2 Host Receptor ACE2 Protein Expression Atlas in Human Gastrointestinal Tract. PMID:34178985
Meta-Analysis of Smooth Muscle Lineage Transcriptomes in Atherosclerosis and Their Relationships to In Vitro Models. PMID:34178388
Assembling Disease Networks From Causal Interaction Resources. PMID:34178043
Whole-Exome Sequencing Analysis of Human Semen Quality in Russian Multiethnic Population. PMID:34178030
Malignant cerebral infarction associated with COVID-19 in a child. PMID:34175976
ELIXIR: Providing a Sustainable Infrastructure for Life Science Data at European Scale. PMID:34175941
A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action. PMID:34173964
Dysregulation of the secretory pathway connects Alzheimer's disease genetics to aggregate formation. PMID:34171228
FINER: enhancing the prediction of tissue-specific functions of isoforms by refining isoform interaction networks. PMID:34169280
Identification of a Locus on the X Chromosome Linked to Familial Membranous Nephropathy. PMID:34169208
In silico analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients. PMID:34168096
SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19. PMID:34161337
Phosphatidylserine Receptors Enhance SARS-CoV-2 Infection: AXL as a Therapeutic Target for COVID-19. PMID:34159331
Super-resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement. PMID:34156149
Single-Nucleus RNA Sequencing Identifies New Classes of Proximal Tubular Epithelial Cells in Kidney Fibrosis. PMID:34155061
Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation. PMID:34154587
Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study. PMID:34151794
Protein and Microbial Biomarkers in Sputum Discern Acute and Latent Tuberculosis in Investigation of Pastoral Ethiopian Cohort. PMID:34150670
A Poliovirus Receptor (CD155)-Related Risk Signature Predicts the Prognosis of Bladder Cancer. PMID:34150627
Upregulation of LIMK1 Is Correlated With Poor Prognosis and Immune Infiltrates in Lung Adenocarcinoma. PMID:34149814
CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients. PMID:34149710
Synthesis, biological evaluation, molecular modeling, and structural analysis of new pyrazole and pyrazolone derivatives as N-formyl peptide receptors agonists. PMID:34148303
AdaTiSS: A Novel Data-Adaptive Robust Method for Identifying Tissue Specificity Scores. PMID:34146104
Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype. PMID:34145395
Analyzing cancer gene expression data through the lens of normal tissue-specificity. PMID:34143767
Endosomes as Signaling Platforms for IL-6 Family Cytokine Receptors. PMID:34141712
Using Tumor-Infiltrating Immune Cells and a ceRNA Network Model to Construct a Prognostic Analysis Model of Thyroid Carcinoma. PMID:34141614
Key Macrophage Responses to Infection With Mycobacterium tuberculosis Are Co-Regulated by microRNAs and DNA Methylation. PMID:34140955
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. PMID:34140493
Current Methodological Challenges of Single-Cell and Single-Nucleus RNA-Sequencing in Glomerular Diseases. PMID:34140401
Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (1): specific signatures of stromal, glandular and luminal epithelial cells. PMID:34139994
STING pathway expression in low-grade serous carcinoma of the ovary: an unexpected therapeutic opportunity? PMID:34138519
BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae. PMID:34137374
Identification of Genes Related to Immune Infiltration in the Tumor Microenvironment of Cutaneous Melanoma. PMID:34136377
pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis. PMID:34135065
Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome. PMID:34131099
Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease. PMID:34129723
Independent duplications of the Golgi phosphoprotein 3 oncogene in birds. PMID:34127736
Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells. PMID:34125594
Mechanisms of Neoantigen-Targeted Induction of Pyroptosis and Ferroptosis: From Basic Research to Clinical Applications. PMID:34123855
Demographics and risk factors for pediatric recurrent acute pancreatitis. PMID:34120130
Protein Microarrays for Ocular Diseases. PMID:34115364
Analysis of Protein-Protein Interactions by Protein Microarrays. PMID:34115353
Haploinsufficiency of ARFGEF1 is associated with developmental delay, intellectual disability, and epilepsy with variable expressivity. PMID:34113008
Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms. PMID:34112237
A meta-analysis of transcriptomic profiles of Huntington's disease patients. PMID:34111223
Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis. PMID:34110423
Machine learning-aided protein identification from multidimensional signatures. PMID:34109955
Differential Regulation of GPCRs-Are GRK Expression Levels the Key? PMID:34109182
Specialty Grand Challenge for Molecular Signalling and Pathways in Molecular Neuroscience. PMID:34108865
60 Years Young: The Evolving Role of Allogeneic Hematopoietic Stem Cell Transplantation in Cancer Immunotherapy. PMID:34108142
Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer. PMID:34108014
Identification of DNA methylation biomarkers for risk of liver metastasis in early-stage colorectal cancer. PMID:34108011
Tissue- and stage-specific landscape of the mouse translatome. PMID:34107020
CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes. PMID:34106789
A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy. PMID:34106735
Development of Parallel Reaction Monitoring Assays for the Detection of Aggressive Prostate Cancer Using Urinary Glycoproteins. PMID:34106707
Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease. PMID:34100423
Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease. PMID:34100014
A metabolic modeling approach reveals promising therapeutic targets and antiviral drugs to combat COVID-19. PMID:34099831
HOXA13 in etiology and oncogenic potential of Barrett's esophagus. PMID:34099670
miR-105-5p regulates PD-L1 expression and tumor immunogenicity in gastric cancer. PMID:34098061
Low Expression of RILPL2 Predicts Poor Prognosis and Correlates With Immune Infiltration in Endometrial Carcinoma. PMID:34095226
ITGA3 Is Associated With Immune Cell Infiltration and Serves as a Favorable Prognostic Biomarker for Breast Cancer. PMID:34094951
Metabolic protein phosphoglycerate kinase 1 confers lung cancer migration by directly binding HIV Tat specific factor 1. PMID:34091600
Aquaporins in insulin resistance and diabetes: More than channels! PMID:34090243
Proteomics-Based Insights Into the SARS-CoV-2-Mediated COVID-19 Pandemic: A Review of the First Year of Research. PMID:34089862
Tumor cells express pauci- and oligomannosidic N-glycans in glycoproteins recognized by the mannose receptor (CD206). PMID:34089345
Vertical transmission of SARS-CoV-2: A prospective cross-sectional study from a tertiary center. PMID:34081331
A proximity-dependent biotinylation map of a human cell. PMID:34079125
Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability. PMID:34078926
NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA. PMID:34078910
Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis. PMID:34078402
COVID-19 disrupts spermatogenesis through the oxidative stress pathway following induction of apoptosis. PMID:34076792
PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2). PMID:34075397
Broad auto-reactive IgM responses are common in critically ill patients, including those with COVID-19. PMID:34075365
Evolution and function of the epithelial cell-specific ER stress sensor IRE1β. PMID:34075183
Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation. PMID:34074730
Principles and Current Clinical Landscape of Multispecific Antibodies against Cancer. PMID:34073188
NKL Homeobox Gene VENTX Is Part of a Regulatory Network in Human Conventional Dendritic Cells. PMID:34072771
In-Silico Evaluation of Genetic Alterations in Ovarian Carcinoma and Therapeutic Efficacy of NSC777201, as a Novel Multi-Target Agent for TTK, NEK2, and CDK1. PMID:34072728
Ubiquitin Proteasome Pathway Transcriptome in Epithelial Ovarian Cancer. PMID:34071321
Identification of Candidate Protein Biomarkers for CIN2+ Lesions from Self-Sampled, Dried Cervico-Vaginal Fluid Using LC-MS/MS. PMID:34070587
A Synthetic Peptide CTL Vaccine Targeting Nucleocapsid Confers Protection from SARS-CoV-2 Challenge in Rhesus Macaques. PMID:34070152
foxm1 Modulates Cell Non-Autonomous Response in Zebrafish Skeletal Muscle Homeostasis. PMID:34070077
Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives. PMID:34067719
The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma. PMID:34067658
Oncogenic Potential of the Dual-Function Protein MEX3A. PMID:34067172
Western Diet Induced Remodelling of the Tongue Proteome. PMID:34066295
Cascading from SARS-CoV-2 to Parkinson's Disease through Protein-Protein Interactions. PMID:34066091
Network Pharmacological Analysis through a Bioinformatics Approach of Novel NSC765600 and NSC765691 Compounds as Potential Inhibitors of CCND1/CDK4/PLK1/CD44 in Cancer Types. PMID:34063946
BHK-21 Cell Clones Differ in Chikungunya Virus Infection and MXRA8 Receptor Expression. PMID:34063936
The Potential Protective Role of RUNX1 in Nonalcoholic Fatty Liver Disease. PMID:34063472
Advances and perspectives in discovery and functional analysis of small secreted proteins in plants. PMID:34059650
In vivo gene editing via homology-independent targeted integration for adrenoleukodystrophy treatment. PMID:34058389
Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin. PMID:34057753
Autophagy and ALS: mechanistic insights and therapeutic implications. PMID:34057020
Native-like SARS-CoV-2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine. PMID:34056089
CBFβ promotes colorectal cancer progression through transcriptionally activating OPN, FAM129A, and UPP1 in a RUNX2-dependent manner. PMID:34050318
Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer. PMID:34047812
Quantitative proteomic biomarkers from extracellular vesicles of human seminal plasma in the differential diagnosis of azoospermia. PMID:34047465
Assessing the functional relevance of splice isoforms. PMID:34046593
Decoding Neuromuscular Disorders Using Phenotypic Clusters Obtained From Co-Occurrence Networks. PMID:34046427
A Novel Ferroptosis Related Gene Signature for Prognosis Prediction in Patients With Colon Cancer. PMID:34046350
Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1. PMID:34041485
GWENA: gene co-expression networks analysis and extended modules characterization in a single Bioconductor package. PMID:34034647
The Human Salivary Proteome Wiki: A Community-Driven Research Platform. PMID:34032471
Tutorial: guidelines for annotating single-cell transcriptomic maps using automated and manual methods. PMID:34031612
Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo. PMID:34031270
Integrative analysis of the human brain mural cell transcriptome. PMID:34027687
Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity. PMID:34027339
Functional Variants Surrounding Endothelin 2 Are Associated With Mycobacterium avium Subspecies paratuberculosis Infection. PMID:34026885
Cellular Mechanisms of Liver Fibrosis. PMID:34025430
SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ferroptosis, endoplasmic reticulum stress and DNA synthesis. PMID:34023458
Up-regulated RFC2 predicts unfavorable progression in hepatocellular carcinoma. PMID:34022962
Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets. PMID:34022127
Genetic mapping of metabolic traits in the blind Mexican cavefish reveals sex-dependent quantitative trait loci associated with cave adaptation. PMID:34020589
Comprehensive analysis of the prognostic value and immune function of the IDO1 gene in gynecological cancers. PMID:34017374
Identification and Validation of a Six Immune-Related Genes Signature for Predicting Prognosis in Patients With Stage II Colorectal Cancer. PMID:34017356
Divergent Dimethylarginine Dimethylaminohydrolase Isoenzyme Expression in the Central Nervous System. PMID:34014421
Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival. PMID:34013359
An Exploration of the Tumor Microenvironment Identified a Novel Five-Gene Model for Predicting Outcomes in Bladder Cancer. PMID:34012914
Novel Alzheimer's disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers. PMID:34011927
A method to delineate de novo missense variants across pathways prioritizes genes linked to autism. PMID:34011629
Critical appraisal of the mechanisms of gastrointestinal and hepatobiliary infection by COVID-19. PMID:34009033
The selective alpha7 nicotinic acetylcholine receptor agonist AR-R17779 does not affect ischemia-reperfusion brain injury in mice. PMID:34008839
Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris. PMID:34003106
Downregulation of USP18 reduces tumor-infiltrating activated dendritic cells in extranodal diffuse large B cell lymphoma patients. PMID:34001679
Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells. PMID:34001596
Single cell RNA-seq analysis of the flexor digitorum brevis mouse myofibers. PMID:34001262
The fructose-1,6-bisphosphatase deficiency and the p.(Lys204ArgfsTer72) variant. PMID:33999094
Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1. PMID:33997693
LINC02257, an Enhancer RNA of Prognostic Value in Colon Adenocarcinoma, Correlates With Multi-Omics Immunotherapy-Related Analysis in 33 Cancers. PMID:33996902
Ferroptosis-Related Gene Signature Accurately Predicts Survival Outcomes in Patients With Clear-Cell Renal Cell Carcinoma. PMID:33996565
Network Analyses Predict Small RNAs That Might Modulate Gene Expression in the Testis and Epididymis of Bos indicus Bulls. PMID:33995471
Inborn disorders of the malate aspartate shuttle. PMID:33990986
G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis. PMID:33990686
HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1. PMID:33990627
Histone H3K9 butyrylation is regulated by dietary fat and stress via an Acyl-CoA dehydrogenase short chain-dependent mechanism. PMID:33989779
Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1. PMID:33986741
Targeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma. PMID:33986254
Novel Strategies to Address the Challenges in Top-Down Proteomics. PMID:33983025
Early onset epilepsy and sudden unexpected death in epilepsy with cardiac arrhythmia in mice carrying the early infantile epileptic encephalopathy 47 gain-of-function FHF1(FGF12) missense mutation. PMID:33982289
Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents. PMID:33981016
Ketamine disrupts naturalistic coding of working memory in primate lateral prefrontal cortex networks. PMID:33981008
Endocannabinoid signaling pathways: beyond CB1R and CB2R. PMID:33978927
Synthetic Biology: Emerging Concepts to Design and Advance Adeno-Associated Viral Vectors for Gene Therapy. PMID:33977059
Missense mutations in small muscle protein X-linked (SMPX) cause distal myopathy with protein inclusions. PMID:33974137
Omics community detection using multi-resolution clustering. PMID:33974004
hu.MAP 2.0: integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies. PMID:33973408
Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data. PMID:33972534
Knowledge bases and software support for variant interpretation in precision oncology. PMID:33971666
Validation of the functions and prognostic values of synapse-associated proteins in lower-grade glioma. PMID:33969375
One-Year Prospective Study of Plasma Biomarkers From CNS in Patients With Mild Traumatic Brain Injury. PMID:33967940
WNK1 is an assembly factor for the human ER membrane protein complex. PMID:33964204
Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa. PMID:33963188
Defining functional variants associated with Alzheimer's disease in the induced immune response. PMID:33959712
Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance. PMID:33953682
Mass Spectral Analysis of Synthetic Peptides: Implications in Proteomics. PMID:33953644
Ferret Interferon (IFN)-Inducible Transmembrane Proteins Are Upregulated by both IFN-α and Influenza Virus Infection. PMID:33952646
A Human Endogenous Bornavirus-Like Nucleoprotein Encodes a Mitochondrial Protein Associated with Cell Viability. PMID:33952640
Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy. PMID:33952630
Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer. PMID:33952262
A Review of Functional Characterization of Single Amino Acid Change Mutations in HNF Transcription Factors in MODY Pathogenesis. PMID:33950347
Down-regulation of microRNA-125b-2-3p is a risk factor for a poor prognosis in hepatocellular carcinoma. PMID:33949293
Establishment and verification of prognostic model for gastric cancer based on autophagy-related genes. PMID:33948361
Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence. PMID:33947761
Glutathione S-Transferases in Cancer. PMID:33946704
Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells. PMID:33946672
Structural Variants Selected during Yak Domestication Inferred from Long-Read Whole-Genome Sequencing. PMID:33944937
Protein structure-based gene expression signatures. PMID:33941686
Cerebral organoids and their potential for studies of brain diseases in domestic animals. PMID:33941270
A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression. PMID:33937393
Identification of novel bladder sensory GPCRs. PMID:33932109
Mesothelin/CD3 half-life extended bispecific T-cell engager molecule shows specific tumor uptake and distributes to mesothelin and CD3 expressing tissues. PMID:33931466
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer. PMID:33931024
Second-Trimester Placental and Thyroid Hormones Are Associated With Cognitive Development From Ages 1 to 3 Years. PMID:33928202
Identification of SHMT2 as a Potential Prognostic Biomarker and Correlating with Immune Infiltrates in Lung Adenocarcinoma. PMID:33928169
Nanobodies for Medical Imaging: About Ready for Prime Time? PMID:33925941
Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness. PMID:33924911
Muscle Glycogen Phosphorylase and Its Functional Partners in Health and Disease. PMID:33924466
Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues. PMID:33923459
RNA-Binding Protein HuD as a Versatile Factor in Neuronal and Non-Neuronal Systems. PMID:33922479
Eps15 Homology Domain-Containing Protein 3 Hypermethylation as a Prognostic and Predictive Marker for Colorectal Cancer. PMID:33922189
Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer. PMID:33921749
Multiplexed In Situ Protein Profiling with High-Performance Cleavable Fluorescent Tyramide. PMID:33921211
The Leloir Cycle in Glioblastoma: Galactose Scavenging and Metabolic Remodeling. PMID:33920278
Ultramicronized Palmitoylethanolamide (um-PEA): A New Possible Adjuvant Treatment in COVID-19 patients. PMID:33917573
Functional Roles of SPINK1 in Cancers. PMID:33916984
A molecular single-cell lung atlas of lethal COVID-19. PMID:33915568
In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung. PMID:33915162
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids. PMID:33915081
A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases. PMID:33913706
Seven Glycolysis-Related Genes Predict the Prognosis of Patients With Pancreatic Cancer. PMID:33912561
Engineering Extracellular Vesicles to Target Pancreatic Tissue In Vivo. PMID:33912378
CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Acting in cis. PMID:33910952
Prognostic value of SH3PXD2B (Tks4) in human hepatocellular carcinoma: a combined multi-omics and experimental study. PMID:33906640
Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11. PMID:33901943
A coupled enzyme assay for detection of selenium-binding protein 1 (SELENBP1) methanethiol oxidase (MTO) activity in mature enterocytes. PMID:33901808
Identification of hub genes associated with obesity-induced hepatocellular carcinoma risk based on integrated bioinformatics analysis. PMID:33900477
Systemic analysis of the expression levels and prognosis of breast cancer-related cadherins. PMID:33899544
Sex-Specific Role for SLIT1 in Regulating Stress Susceptibility. PMID:33896623
Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli. PMID:33893305
The VRNetzer platform enables interactive network analysis in Virtual Reality. PMID:33893283
Pharmacological inhibition of USP30 activates tissue-specific mitophagy. PMID:33890401
Glutathione-related genetic polymorphisms are associated with mercury retention and nephrotoxicity in gold-mining settings of a Colombian population. PMID:33888803
A comprehensive characterization of the cell-free transcriptome reveals tissue- and subtype-specific biomarkers for cancer detection. PMID:33883548
Epigenome-wide association study of level and change in cognitive abilities from midlife through late life. PMID:33883019
Dual RNA Sequencing Meta-analysis in Plasmodium Infection Identifies Host-Parasite Interactions. PMID:33879496
Induced pluripotent stem cells from subjects with Lesch-Nyhan disease. PMID:33875724
The Association of Mitochondrial Copy Number With Sarcopenia in Adult Survivors of Childhood Cancer. PMID:33871611
Whole genome transcriptome analysis of the stomach resected in human vertical sleeve gastrectomy: cutting more than calories. PMID:33870723
Urea as a By-Product of Ammonia Metabolism Can Be a Potential Serum Biomarker of Hepatocellular Carcinoma. PMID:33869206
SLC39A8/Zinc Suppresses the Progression of Clear Cell Renal Cell Carcinoma. PMID:33869056
Identification of IFN-Induced Transmembrane Protein 1 With Prognostic Value in Pancreatic Cancer Using Network Module-Based Analysis. PMID:33869009
GPCards: An integrated database of genotype-phenotype correlations in human genetic diseases. PMID:33868597
Small Molecule Targeting of Oxysterol-Binding Protein (OSBP)-Related Protein 4 and OSBP Inhibits Ovarian Cancer Cell Proliferation in Monolayer and Spheroid Cell Models. PMID:33860198
Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets. PMID:33859189
Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery. PMID:33859163
HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy. PMID:33858848
A novel predicted ADP-ribosyltransferase-like family conserved in eukaryotic evolution. PMID:33854844
Familial wild-type gastrointestinal stromal tumour in association with germline truncating variants in both SDHA and PALB2. PMID:33854214
Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer. PMID:33854168
Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms. PMID:33852859
Growth Hormone Releasing Hormone Reduces Circulating Markers of Immune Activation in Parallel with Effects on Hepatic Immune Pathways in Individuals with HIV-infection and Nonalcoholic Fatty Liver Disease. PMID:33852720
The gut microbiome and arsenic-induced disease-iAs metabolism in mice. PMID:33852125
Y chromosome copy number variation and its effects on fertility and other health factors: a review. PMID:33850773
TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes. PMID:33849445
iNetModels 2.0: an interactive visualization and database of multi-omics data. PMID:33849075
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones. PMID:33846299
Evaluation and Refinement of Sample Preparation Methods for Extracellular Matrix Proteome Coverage. PMID:33845168
Identification of Stemness-Related Genes for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma by Integrated Bioinformatics Analysis. PMID:33842467
Neurology and the COVID-19 Pandemic: Gathering Data for an Informed Response. PMID:33842072
TIGIT-Fc as a Potential Therapeutic Agent for Fetomaternal Tolerance. PMID:33841433
Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs. PMID:33839157
The circulating soluble form of the CD40 costimulatory immune checkpoint receptor and liver metastasis risk in rectal cancer. PMID:33837301
Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective. PMID:33835398
Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain. PMID:33833410
L Antigen Family Member 3 Serves as a Prognostic Biomarker for the Clinical Outcome and Immune Infiltration in Skin Cutaneous Melanoma. PMID:33829062
Regulation of Synaptic Transmission and Plasticity by Protein Phosphatase 1. PMID:33827970
CAR-T Cell Therapy for Acute Myeloid Leukemia: Preclinical Rationale, Current Clinical Progress, and Barriers to Success. PMID:33826079
TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation. PMID:33823896
Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single cell analysis. PMID:33821282
Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression. PMID:33819739
Studies of the role of basophils in aspirin-exacerbated respiratory disease pathogenesis. PMID:33819512
The Effect of Sodium Glucose Cotransporter 2 Inhibitors From a Human Genetic Perspective. PMID:33815487
Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Agents. PMID:33815364
LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling. PMID:33815143
Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis. PMID:33812333
Ferroptosis, trophoblast lipotoxic damage, and adverse pregnancy outcome. PMID:33812183
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. PMID:33811184
Growth Arrest-Specific Factor 6 (GAS6) Is Increased in COVID-19 Patients and Predicts Clinical Outcome. PMID:33810394
Aminopeptidase Expression in Multiple Myeloma Associates with Disease Progression and Sensitivity to Melflufen. PMID:33810334
Structural Biology and Structure-Function Relationships of Membrane Proteins. PMID:33809831
Dimethyl Sulfoxide: Morphological, Histological, and Molecular View on Developing Chicken Liver. PMID:33809222
Large Scale Molecular Studies of Pituitary Neuroendocrine Tumors: Novel Markers, Mechanisms and Translational Perspectives. PMID:33808624
Negative Regulation of the Innate Immune Response through Proteasomal Degradation and Deubiquitination. PMID:33808506
CD5L as an Extracellular Vesicle-Derived Biomarker for Liquid Biopsy of Lung Cancer. PMID:33808296
Evaluation of Fast Molecular Detection of Lymph Node Metastases in Prostate Cancer Patients Using One-Step Nucleic Acid Amplification (OSNA). PMID:33807774
More Than Meets the Eye: Revisiting the Roles of Heat Shock Factor 4 in Health and Diseases. PMID:33807297
Quantitative Proteomics Analysis of Berberine-Treated Colon Cancer Cells Reveals Potential Therapy Targets. PMID:33806918
A Comparative in Silico Analysis of CD24's Prognostic Value in Human and Canine Prostate Cancer. PMID:33806857
Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the Interface between Metabolism and Cell Cycle: A Systematic Review. PMID:33806509
Identifying Molecular Signatures of Distinct Modes of Collective Migration in Response to the Microenvironment Using Three-Dimensional Breast Cancer Models. PMID:33804802
Endothelial Autocrine Signaling through CXCL12/CXCR4/FoxM1 Axis Contributes to Severe Pulmonary Arterial Hypertension. PMID:33804745
AtFAHD1a: A New Player Influencing Seed Longevity and Dormancy in Arabidopsis? PMID:33804275
Leptin Is Associated with Poor Clinical Outcomes and Promotes Clear Cell Renal Cell Carcinoma Progression. PMID:33804101
The Biological Significance of Targeting Acetylation-Mediated Gene Regulation for Designing New Mechanistic Tools and Potential Therapeutics. PMID:33803759
Combined De-Repression of Chemoresistance Associated Mitogen-Activated Protein Kinase 14 and Activating Transcription Factor 2 by Loss of microRNA-622 in Hepatocellular Carcinoma. PMID:33803354
Relevance of 2'-O-Methylation and Pseudouridylation for the Malignant Melanoma. PMID:33803145
Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era. PMID:33802862
Proof-of-Concept: Antisense Oligonucleotide Mediated Skipping of Fibrillin-1 Exon 52. PMID:33801742
The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases. PMID:33800554
Leptin and Cancer: Updated Functional Roles in Carcinogenesis, Therapeutic Niches, and Developments. PMID:33799880
β3-Adrenoreceptors as ROS Balancer in Hematopoietic Stem Cell Transplantation. PMID:33799536
Oncolytic Virus Therapy Alters the Secretome of Targeted Glioblastoma Cells. PMID:33799381
SARS-CoV-2 as Enteric Virus in Wastewater: Which Risk on the Environment and Human Behavior? PMID:33795937
The Functional Classification of ORF8 in SARS-CoV-2 Replication, Immune Evasion, and Viral Pathogenesis Inferred through Phylogenetic Profiling. PMID:33795929
A Critical Role of Peptidylprolyl Isomerase A Pseudogene 22/microRNA-197-3p/Peptidylprolyl Isomerase A Axis in Hepatocellular Carcinoma. PMID:33790943
Adaptive gene misregulation. PMID:33789344
Consensus Transcriptional Landscape of Human End-Stage Heart Failure. PMID:33787284
Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B-related hepatocellular carcinoma. PMID:33783990
Gastrointestinal Symptoms Predict the Outcomes From COVID-19 Infection. PMID:33780223
Atypical focal segmental glomerulosclerosis associated with a new PODXL nonsense variant. PMID:33780168
Distinct genomic features across cytolytic subgroups in skin melanoma. PMID:33779796
USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization. PMID:33777217
The Molecular Function of PURA and Its Implications in Neurological Diseases. PMID:33777106
Degradation from the outside in: Targeting extracellular and membrane proteins for degradation through the endolysosomal pathway. PMID:33770486
Loss-of-Function Variants in the SYNPO2L Gene Are Associated With Atrial Fibrillation. PMID:33768119
Overexpression of NPTX2 Promotes Malignant Phenotype of Epithelial Ovarian Carcinoma via IL6-JAK2/STAT3 Signaling Pathway Under Hypoxia. PMID:33768003
Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19. PMID:33767597
Denoising large-scale biological data using network filters. PMID:33765911
Effect of small molecule eRF3 degraders on premature termination codon readthrough. PMID:33764477
Down-regulation of solute carrier family 10 member 1 is associated with early recurrence and poorer prognosis of hepatocellular carcinoma. PMID:33763615
Critical role of mass spectrometry proteomics in tear biomarker discovery for multifactorial ocular diseases (Review). PMID:33760148
Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment. PMID:33758004
A single-cell survey of the human glomerulonephritis. PMID:33754492
GPRC5A: An emerging prognostic biomarker for predicting malignancy of Pancreatic Cancer based on bioinformatics analysis. PMID:33753999
Comprehensive analysis of ceRNA networks reveals prognostic lncRNAs related to immune infiltration in colorectal cancer. PMID:33750326
Integrated intra- and intercellular signaling knowledge for multicellular omics analysis. PMID:33749993
A Natural Xenogeneic Endometrial Extracellular Matrix Hydrogel Toward Improving Current Human in vitro Models and Future in vivo Applications. PMID:33748086
Comprehensive Analysis of the Immune and Prognostic Implication of COL6A6 in Lung Adenocarcinoma. PMID:33747955
Identification of Five Glycolysis-Related Gene Signature and Risk Score Model for Colorectal Cancer. PMID:33747908
Identification of MEG8/miR-378d/SOBP axis as a novel regulatory network and associated with immune infiltrates in ovarian carcinoma by integrated bioinformatics analysis. PMID:33742531
HDL biodistribution and brain receptors in zebrafish, using HDLs as vectors for targeting endothelial cells and neural progenitors. PMID:33742021
Nidogen-1 expression is associated with overall survival and temozolomide sensitivity in low-grade glioma patients. PMID:33735110
Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1. PMID:33732413
Kidney involvement in coronavirus-associated diseases (Review). PMID:33732334
Molecular clues in the regulation of mini-puberty involve neuronal DNA binding transcription factor NHLH2. PMID:33731013
Tumor levels of the mediators of ErbB2-driven anoikis resistance correlate with breast cancer relapse in patients receiving trastuzumab-based therapies. PMID:33728523
NG2/CSPG4, CD146/MCAM and VAP1/AOC3 are regulated by myocardin-related transcription factors in smooth muscle cells. PMID:33727640
Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen. PMID:33727531
Multi-omics approaches for revealing the complexity of cardiovascular disease. PMID:33725119
Circulating proteins associated with allergy development in infants-an exploratory analysis. PMID:33722194
Quantitative Proteomic Profiling Identifies a Potential Novel Chaperone Marker in Resistant Breast Cancer. PMID:33718123
PD-L1 siRNA Theranostics With a Dextran Nanoparticle Highlights the Importance of Nanoparticle Delivery for Effective Tumor PD-L1 Downregulation. PMID:33718115
Exploration of the Prognostic and Immunotherapeutic Value of B and T Lymphocyte Attenuator in Skin Cutaneous Melanoma. PMID:33718105
Do Molecular Profiles of Primary Versus Metastatic Radioiodine Refractory Differentiated Thyroid Cancer Differ? PMID:33716974
CDH6-activated αIIbβ3 crosstalks with α2β1 to trigger cellular adhesion and invasion in metastatic ovarian and renal cancers. PMID:33715292
Endometrial laminin subunit beta-3 expression associates with reproductive outcome in patients with repeated implantation failure. PMID:33715134
Human OVCA2 and its homolog FSH3-induced apoptosis in Saccharomyces cerevisiae. PMID:33715035
The rise and fall of anandamide: processes that control synthesis, degradation, and storage. PMID:33713246
Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood-brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study. PMID:33712077
Identification of four key prognostic genes and three potential drugs in human papillomavirus negative head and neck squamous cell carcinoma. PMID:33712015
Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI. PMID:33711514
Integrated analysis of RNA-binding proteins in thyroid cancer. PMID:33711033
Proteomic profiling of the interface between the stomach wall and the pancreas in dystrophinopathy. PMID:33709651
Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1. PMID:33709453
Structural Mechanism of Cooperative Regulation of Calcium-Sensing Receptor-Mediated Cellular Signaling. PMID:33709045
LSD1 Promotes Prostate Cancer Cell Survival by Destabilizing FBXW7 at Post-Translational Level. PMID:33708617
Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing. PMID:33708225
Identification of TRIM56 as a Potential Biomarker for Lung Adenocarcinoma. PMID:33707970
Joint analysis of expression levels and histological images identifies genes associated with tissue morphology. PMID:33707455
Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death. PMID:33704068
Calcium-binding and coiled-coil domain 2 promotes the proliferation and suppresses apoptosis of prostate cancer cells. PMID:33692836
Macrophage M2 Co-expression Factors Correlate With the Immune Microenvironment and Predict Outcome of Renal Clear Cell Carcinoma. PMID:33692827
Prosaposin mediates inflammation in atherosclerosis. PMID:33692130
Discovery and validation of PZP as a novel serum biomarker for screening lung adenocarcinoma in type 2 diabetes mellitus patients. PMID:33691685
Gene alteration in zebrafish exposed to a mixture of substances of abuse. PMID:33689951
Enrichment of Placental Trophoblast Cells from Clinical Cervical Samples Using Differences in Surface Adhesion on an Inclined Plane. PMID:33686620
RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors. PMID:33684443
Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. PMID:33683200
CD96 Correlates With Immune Infiltration and Impacts Patient Prognosis: A Pan-Cancer Analysis. PMID:33680972
Exploring the Stress Impact in the Paternal Germ Cells Epigenome: Can Catecholamines Induce Epigenetic Reprogramming? PMID:33679612
Genetic and Epigenetic Regulation of Organic Cation Transporters. PMID:33674913
Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma. PMID:33674603
TRIM Proteins in Colorectal Cancer: TRIM8 as a Promising Therapeutic Target in Chemo Resistance. PMID:33673719
Proteomic Analysis of Low-Grade, Early-Stage Endometrial Carcinoma Reveals New Dysregulated Pathways Associated with Cell Death and Cell Signaling. PMID:33672863
Differential Effects of STCH and Stress-Inducible Hsp70 on the Stability and Maturation of NKCC2. PMID:33672238
Serum Free Amino Acid Profiling in Differential Diagnosis of Ovarian Tumors-A Comparative Study with Review of the Literature. PMID:33672144
Membrane Protein Stabilization Strategies for Structural and Functional Studies. PMID:33671740
Renal Proximal Tubule Cell Cannabinoid-1 Receptor Regulates Bone Remodeling and Mass via a Kidney-to-Bone Axis. PMID:33671138
Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics. PMID:33670680
CAR-T Therapy, the End of a Chapter or the Beginning of a New One? PMID:33670515
Knowledge-Guided "Community Network" Analysis Reveals the Functional Modules and Candidate Targets in Non-Small-Cell Lung Cancer. PMID:33669233
Association between Sour Taste SNP KCNJ2-rs236514, Diet Quality and Mild Cognitive Impairment in an Elderly Cohort. PMID:33668367
Zinc Finger Protein CTCF Regulates Extracellular Matrix (ECM)-Related Gene Expression Associated With the Wnt Signaling Pathway in Gastric Cancer. PMID:33665169
The cancer cell secretome drives cooperative manipulation of the tumour microenvironment to accelerate tumourigenesis. PMID:33659922
Balance between macrophage migration inhibitory factor and sCD74 predicts outcome in patients with acute decompensation of cirrhosis. PMID:33659891
The Changes of Leukocytes in Brain and Blood After Intracerebral Hemorrhage. PMID:33659003
Ablation of CRBN induces loss of type I collagen and SCH in mouse skin by fibroblast senescence via the p38 MAPK pathway. PMID:33658395
Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity. PMID:33658356
Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV). PMID:33657166
Differential proteomic analysis of children infected with respiratory syncytial virus. PMID:33656056
Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds. PMID:33653397
A machine learning-based gene signature of response to the novel alkylating agent LP-184 distinguishes its potential tumor indications. PMID:33653269
Biological impact of mutually exclusive exon switching. PMID:33651795
The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2. PMID:33649974
Combination of miR‑143 and miR‑506 reduces lung and pancreatic cancer cell growth through the downregulation of cyclin‑dependent kinases. PMID:33649787
Synthesis and Initial Characterization of a Selective, Pseudo-irreversible Inhibitor of Human Butyrylcholinesterase as PET Tracer. PMID:33645891
Phenotypic and protein localization heterogeneity associated with AHDC1 pathogenic protein-truncating alleles in Xia-Gibbs syndrome. PMID:33644933
Retinoic Acid Induced Protein 14 (Rai14) is dispensable for mouse spermatogenesis. PMID:33643708
Potential Molecular Mechanism of TNF Superfamily-Related Genes in Glioblastoma Multiforme Based on Transcriptome and Epigenome. PMID:33643183
DbStRiPs: Database of structural repeats in proteins. PMID:33641184
Pregnancy Serum DLK1 Concentrations Are Associated With Indices of Insulin Resistance and Secretion. PMID:33640968
Reflections on the HUPO Human Proteome Project, the Flagship Project of the Human Proteome Organization, at 10 Years. PMID:33640492
Pro-Tumoral Functions of Autophagy Receptors in the Modulation of Cancer Progression. PMID:33634029
Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner. PMID:33633567
Role of the V1G1 subunit of V-ATPase in breast cancer cell migration. PMID:33633298
Novel method for screening functional antibody with comprehensive analysis of its immunoliposome. PMID:33633189
Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis. PMID:33630577
A Novel Missense Variant in the Gene PPP2R5D Causes a Rare Neurodevelopmental Disorder with Increased Phenotype. PMID:33628804
Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants. PMID:33627123
Comprehensive Analysis of Gene Expression Changes and Validation in Hepatocellular Carcinoma. PMID:33623390
The novel roles of virus infection-associated gene CDKN1A in chemoresistance and immune infiltration of glioblastoma. PMID:33621203
Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. PMID:33618763
Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2. PMID:33609069
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. PMID:33606986
Processing and Analysis of RNA-seq Data from Public Resources. PMID:33606253
Applications of Community Detection Algorithms to Large Biological Datasets. PMID:33606252
Bisphenol S and Epidermal Growth Factor Receptor Signaling in Human Placental Cytotrophoblasts. PMID:33605785
Traptamer screening: a new functional genomics approach to study virus entry and other cellular processes. PMID:33604985
Discovering pathways in benign prostate hyperplasia: A functional genomics pilot study. PMID:33603850
Tenascin-W: Discovery, Evolution, and Future Prospects. PMID:33603752
PATZ1 (MAZR) Co-occupies Genomic Sites With p53 and Inhibits Liver Cancer Cell Proliferation via Regulating p27. PMID:33598459
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity. PMID:33594203
Evidence for specificity of polygenic contributions to attainment in English, maths and science during adolescence. PMID:33594131
Genetic and epigenetic factors associated with increased severity of Covid-19. PMID:33590936
Epitope mimicry analysis of SARS-COV-2 surface proteins and human lung proteins. PMID:33588349
Highly Sensitive and Multiplexed Protein Imaging With Cleavable Fluorescent Tyramide Reveals Human Neuronal Heterogeneity. PMID:33585449
Construction of Bone Metastasis-Specific Regulation Network Based on Prognostic Stemness-Related Signatures in Breast Invasive Carcinoma. PMID:33585235
The Peptide Vaccine of the Future. PMID:33583769
Immune cell - produced ROS and their impact on tumor growth and metastasis. PMID:33583736
Subtype-dependent regulation of Gβγ signalling. PMID:33582184
Predicted 'wiring landscape' of Ras-effector interactions in 29 human tissues. PMID:33580066
DNA Mismatch Repair and its Role in Huntington's Disease. PMID:33579865
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome. PMID:33579698
Factorial study of the RNA-seq computational workflow identifies biases as technical gene signatures. PMID:33575596
Global variability analysis of mRNA and protein concentrations across and within human tissues. PMID:33575562
Identification of Three Autophagy-Related Long Non-Coding RNAs as a Novel Head and Neck Squamous Cell Carcinoma Prognostic Signature. PMID:33575215
Key genes in youth colorectal cancer based on data mining and verification by reverse transcription-quantitative PCR. PMID:33574933
Molecular Characterization of Paralichthys olivaceus MAF1 and Its Potential Role as an Anti-Viral Hemorrhagic Septicaemia Virus Factor in Hirame Natural Embryo Cells. PMID:33572970
Human Lectins, Their Carbohydrate Affinities and Where to Find Them. PMID:33572889
SWATH-MS Based Proteomic Profiling of Prostate Cancer Cells Reveals Adaptive Molecular Mechanisms in Response to Anti-Androgen Therapy. PMID:33572476
Glycine Cleavage System H Protein Is Essential for Embryonic Viability, Implying Additional Function Beyond the Glycine Cleavage System. PMID:33569080
LincRNA-immunity landscape analysis identifies EPIC1 as a regulator of tumor immune evasion and immunotherapy resistance. PMID:33568470
Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration. PMID:33567288
ACE2 Is a Prognostic Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma: Implication for COVID-19. PMID:33564310
Classification of node-positive melanomas into prognostic subgroups using keratin, immune, and melanogenesis expression patterns. PMID:33564068
ComHub: Community predictions of hubs in gene regulatory networks. PMID:33563211
Advances in Membranous Nephropathy. PMID:33562791
Urothelium-Specific Deletion of Connexin43 in the Mouse Urinary Bladder Alters Distension-Induced ATP Release and Voiding Behavior. PMID:33562445
Target Score-A Proteomics Data Selection Tool Applied to Esophageal Cancer Identifies GLUT1-Sialyl Tn Glycoforms as Biomarkers of Cancer Aggressiveness. PMID:33562270
Ergothioneine, recent developments. PMID:33558182
Role of the HSP70 Co-Chaperone SIL1 in Health and Disease. PMID:33557244
Targeting the Hippo Pathway in Prostate Cancer: What's New? PMID:33557087
A unique esophageal extracellular matrix proteome alters normal fibroblast function in severe eosinophilic esophagitis. PMID:33556465
Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens. PMID:33554062
Caveolin-1 promotes radioresistance via IRGM-regulated autophagy in lung cancer. PMID:33553340
Up-regulation of L Antigen Family Member 3 Associates With Aggressive Progression of Breast Cancer. PMID:33552947
Engineered Tools to Study Intercellular Communication. PMID:33552865
The clinical significance of glutathione peroxidase 2 in glioblastoma multiforme. PMID:33552592
Construction and Analysis of a ceRNA Network in Cardiac Fibroblast During Fibrosis Based on in vivo and in vitro Data. PMID:33552116
Establishment and validation of an RNA binding protein-associated prognostic model for ovarian cancer. PMID:33550985
RHO GTPases: from new partners to complex immune syndromes. PMID:33547421
Transcriptome comparisons of in vitro intestinal epithelia grown under static and microfluidic gut-on-chip conditions with in vivo human epithelia. PMID:33547413
Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles. PMID:33547159
Potential APOBEC-mediated RNA editing of the genomes of SARS-CoV-2 and other coronaviruses and its impact on their longer term evolution. PMID:33545556
Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types. PMID:33543003
Membrane Interactome of a Recombinant Fragment of Human Surfactant Protein D Reveals GRP78 as a Novel Binding Partner in PC3, a Metastatic Prostate Cancer Cell Line. PMID:33542717
Does C-C Motif Chemokine Ligand 2 (CCL2) Link Obesity to a Pro-Inflammatory State? PMID:33540898
Creatine Metabolism in Female Reproduction, Pregnancy and Newborn Health. PMID:33540766
Making Sense of Intracellular Nucleic Acid Sensing in Type I Interferon Activation in Sjögren's Syndrome. PMID:33540529
Prognostic impact of elevated fatty acid-binding protein 1 in patients with heart failure. PMID:33539661
Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors. PMID:33538575
Vascular Adhesion Protein-1 Determines the Cellular Properties of Endometrial Pericytes. PMID:33537312
Transient receptor potential channels in sensory mechanisms of the lower urinary tract. PMID:33536636
Candidate Biomarkers for Specific Intraoperative Near-Infrared Imaging of Soft Tissue Sarcomas: A Systematic Review. PMID:33535618
Position statement for a pragmatic approach to immunotherapeutics in patients with inflammatory skin diseases during the coronavirus disease 2019 pandemic and beyond. PMID:33533553
Novel coronavirus (COVID-19) and its potential G.I. manifestation: A review. PMID:33532381
Identification of colorectal cancer-associated macrophage biomarkers by integrated bioinformatic analysis. PMID:33532018
Pathophysiologic mechanisms of cerebral endotheliopathy and stroke due to Sars-CoV-2. PMID:33530831
Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding. PMID:33529594
A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. PMID:33526449
DeCompress: tissue compartment deconvolution of targeted mRNA expression panels using compressed sensing. PMID:33524140
S100A8/S100A9 cytokine acts as a transcriptional coactivator during breast cellular transformation. PMID:33523865
Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation length. PMID:33522483
Analysis of Human Faecal Host Proteins: Responsiveness to 10-Week Dietary Intervention Modifying Dietary Protein Intake in Elderly Males. PMID:33521034
ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Infection in COVID-19 Patients. PMID:33521006
Evolutionarily Conserved Long Non-coding RNA Regulates Gene Expression in Cytokine Storm During COVID-19. PMID:33520952
Xia-Gibbs Syndrome: A Review of Literature. PMID:33520547
Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population. PMID:33517564
Verifying explainability of a deep learning tissue classifier trained on RNA-seq data. PMID:33514769
A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis. PMID:33513212
Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci. PMID:33508947
Functional characterization of the dural sinuses as a neuroimmune interface. PMID:33508229
Peroxisomal Metabolite and Cofactor Transport in Humans. PMID:33505966
circRNA circ_102049 Implicates in Pancreatic Ductal Adenocarcinoma Progression through Activating CD80 by Targeting miR-455-3p. PMID:33505218
Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility. PMID:33504897
Multi-organ proteomic landscape of COVID-19 autopsies. PMID:33503446
Association of single-nucleotide polymorphisms in the ESR2 and FSHR genes with poor ovarian response in infertile Jordanian women. PMID:33503363
Comprehensive analysis of PLOD family members in low-grade gliomas using bioinformatics methods. PMID:33503035
Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine. PMID:33501433
Monocytes carrying GFAP detect glioma, brain metastasis and ischaemic stroke, and predict glioblastoma survival. PMID:33501422
HPAStainR: a Bioconductor and Shiny app to query protein expression patterns in the Human Protein Atlas. PMID:33500778
Dual Antimicrobial and Antiproliferative Activity of TcPaSK Peptide Derived from a Tribolium castaneum Insect Defensin. PMID:33499187
Colorectal cancer and COVID-19: Do we need to raise awareness and vigilance? PMID:33498093
Exogenous exposure to dihydroxyacetone mimics high fructose induced oxidative stress and mitochondrial dysfunction. PMID:33496975
Identification of therapeutic targets and prognostic biomarkers from the hnRNP family in invasive breast carcinoma. PMID:33495416
Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging. PMID:33495349
Kidney injury molecule-1 is a potential receptor for SARS-CoV-2. PMID:33493263
Expression and prognostic analyses of SCAMPs in pancreatic adenocarcinoma. PMID:33493138
A new view of macula densa cell microanatomy. PMID:33491562
Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly. PMID:33491286
Olfactory marker protein interacts with adenosine nucleotide derivatives. PMID:33490644
Integrative Expression and Prognosis Analysis of DHX37 in Human Cancers by Data Mining. PMID:33490273
Data-Driven Discovery of Molecular Targets for Antibody-Drug Conjugates in Cancer Treatment. PMID:33490264
Transcriptomic and Network Analysis of Minor Salivary Glands of Patients With Primary Sjögren's Syndrome. PMID:33488608
Growth Hormone and Neuronal Hemoglobin in the Brain-Roles in Neuroprotection and Neurodegenerative Diseases. PMID:33488521
Update of genetic variants in CEP120 and CC2D2A-With an emphasis on genotype-phenotype correlations, tissue specific transcripts and exploring mutation specific exon skipping therapies. PMID:33486889
De-coding genetic risk variants in type 1 diabetes. PMID:33483996
Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model. PMID:33483609
Urinary proteome profiling for stratifying patients with familial Parkinson's disease. PMID:33481347
Membranous nephropathy: current understanding of various causes in light of new target antigens. PMID:33480620
Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases. PMID:33479664
Study of the active ingredients and mechanism of Sparganii rhizoma in gastric cancer based on HPLC-Q-TOF-MS/MS and network pharmacology. PMID:33479376
Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma. PMID:33479234
Developmental cell programs are co-opted in inflammatory skin disease. PMID:33479125
Proteomics analysis of a human brain sample from a mucolipidosis type IV patient reveals pathophysiological pathways. PMID:33478506
Suprabasin-A Review. PMID:33477529
Diet and PPARG2 Pro12Ala Polymorphism Interactions in Relation to Cancer Risk: A Systematic Review. PMID:33477496
The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk. PMID:33476202
Targeting 5-HT2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling After Myocardial Infarction. PMID:33474971
Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate. PMID:33473133
Cellinker: a platform of ligand-receptor interactions for intercellular communication analysis. PMID:33471060
Terminal Deoxynucleotidyl Transferase Commonly Expresses in Germ Cell Tumors: Evaluation on a Large Series from Multiple Centers. PMID:33469349
Prognostic role of PHYH for overall survival (OS) in clear cell renal cell carcinoma (ccRCC). PMID:33468235
Functional Evaluation of a Rare Variant c.516G>C (p.Trp172Cys) in the GJB2 (Connexin 26) Gene Associated with Nonsyndromic Hearing Loss. PMID:33466560
Calcium-Dependent Translocation of S100B Is Facilitated by Neurocalcin Delta. PMID:33466232
Identification of potential biomarkers of peripheral blood mononuclear cell in hepatocellular carcinoma using bioinformatic analysis: A protocol for systematic review and meta-analysis. PMID:33466191
Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach. PMID:33462259
Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model. PMID:33456582
Atrial fibrillation rhythm is associated with marked changes in metabolic and myofibrillar protein expression in left atrial appendage. PMID:33454842
Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation. PMID:33453420
Androglobin gene expression patterns and FOXJ1-dependent regulation indicate its functional association with ciliogenesis. PMID:33453283
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection. PMID:33452205
The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases? PMID:33451033
Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations. PMID:33450391
GPER1 is required to protect fetal health from maternal inflammation. PMID:33446553
CARD8 and IL1B Polymorphisms Influence MRI Brain Patterns in Newborns with Hypoxic-Ischemic Encephalopathy Treated with Hypothermia. PMID:33445495
Donor genetic variants as risk factors for thrombosis after liver transplantation: A genome-wide association study. PMID:33445220
Increased expression of CELSR3 indicates a poor prognostic factor for Prostate Cancer. PMID:33442409
Human leukocyte antigen class II quantification by targeted mass spectrometry in dendritic-like cell lines and monocyte-derived dendritic cells. PMID:33441579
Accurate and efficient detection of gene fusions from RNA sequencing data. PMID:33441414
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients. PMID:33441124
Expansion of NEUROD2 phenotypes to include developmental delay without seizures. PMID:33438828
Longitudinal saliva omics responses to immune perturbation: a case study. PMID:33436912
Cytoplasmic short linear motifs in ACE2 and integrin β3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy. PMID:33436498
Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications. PMID:33436497
CHD2-Related CNS Pathologies. PMID:33435571
GPR55 Receptor Activation by the N-Acyl Dopamine Family Lipids Induces Apoptosis in Cancer Cells via the Nitric Oxide Synthase (nNOS) Over-Stimulation. PMID:33435517
Of numbers and movement - understanding transcription factor pathogenesis by advanced microscopy. PMID:33433399
The secretome mouse provides a genetic platform to delineate tissue-specific in vivo secretion. PMID:33431665
Experimental Models to Study COVID-19 Effect in Stem Cells. PMID:33430424
Combined RNA/tissue profiling identifies novel Cancer/testis genes. PMID:33426787
Variants in PPP2R2B and IGF2BP3 are associated with higher tau deposition. PMID:33426524
Alpha2-Antiplasmin: The Devil You Don't Know in Cerebrovascular and Cardiovascular Disease. PMID:33426005
In Search of Zonation Markers to Identify Liver Functional Disorders. PMID:33425221
Mechanistic Modeling of Gene Regulation and Metabolism Identifies Potential Targets for Hepatocellular Carcinoma. PMID:33424926
Comparative Analysis of Dorsal Root, Nodose and Sympathetic Ganglia for the Development of New Analgesics. PMID:33424545
An "expressionistic" look at serrated precancerous colorectal lesions. PMID:33423702
Identification of key modules and hub genes in glioblastoma multiforme based on co-expression network analysis. PMID:33423377
Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum. PMID:33419470
TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway. PMID:33419081
Patient-Derived Organotypic Epithelial Rafts Model Phenotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis. PMID:33418959
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. PMID:33417831
KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway. PMID:33416175
Improved secretion of recombinant human IL-25 in HEK293 cells using a signal peptide-pro-peptide domain derived from Trypsin-1. PMID:33415569
ACOX2 is a prognostic marker and impedes the progression of hepatocellular carcinoma via PPARα pathway. PMID:33414412
Differential and spatial expression meta-analysis of genes identified in genome-wide association studies of depression. PMID:33414381
Sex-dependent differences in the secretome of human endothelial cells. PMID:33413676
MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility. PMID:33408244
Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome. PMID:33406800
Role of pattern recognition receptors and the microbiota in neurological disorders. PMID:33404072
Circulating MicroRNAs in Relation to Esophageal Adenocarcinoma Diagnosis and Survival. PMID:33403483
Oncogenic and tumor suppressor function of MEIS and associated factors. PMID:33402862
Broad Auto-Reactive IgM Responses Are Common In Critically Ill COVID-19 Patients. PMID:33398261
Hereditary Hearing Impairment with Cutaneous Abnormalities. PMID:33396879
Identifying Personalized Metabolic Signatures in Breast Cancer. PMID:33396819
TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue. PMID:33396509
Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1. PMID:33395526
Loss of LIMCH1 predicts poor prognosis in patients with surgically resected Lung Adenocarcinoma: A study based on Immunohistochemical Analysis and Bioinformatics. PMID:33391414
Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma. PMID:33390805
Bioinformatics Analyses of Potential miRNA-mRNA Regulatory Axis in HBV-related Hepatocellular Carcinoma. PMID:33390802
Evaluation of Male Fertility-Associated Loci in a European Population of Patients with Severe Spermatogenic Impairment. PMID:33383876
Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure. PMID:33382739
Promotion of vascular integrity in sepsis through modulation of bioactive adrenomedullin and dipeptidyl peptidase 3. PMID:33381880
Validation of CSN1S1 transcriptional expression, promoter methylation, and prognostic power in breast cancer using independent datasets. PMID:33381666
Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation. PMID:33381480
FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases. PMID:33381084
The Skin Interactome: A Holistic "Genome-Microbiome-Exposome" Approach to Understand and Modulate Skin Health and Aging. PMID:33380819
Understanding the unimodal distributions of cancer occurrence rates: it takes two factors for a cancer to occur. PMID:33377150
Protocol for the Bottom-Up Proteomic Analysis of Mouse Spleen. PMID:33377090
Secret3D Workflow for Secretome Analysis. PMID:33377056
Immunohistochemical Analysis of PGC-1α and ERRα Expression Reveals Their Clinical Significance in Human Ovarian Cancer. PMID:33376354
C-type Lectin CD209L/L-SIGN and CD209/DC-SIGN: Cell Adhesion Molecules Turned to Pathogen Recognition Receptors. PMID:33375175
Sorting Nexins in Protein Homeostasis. PMID:33374212
Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19. PMID:33373644
HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails. PMID:33372037
Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma. PMID:33365083
The Future of GDNF in Parkinson's Disease. PMID:33364933
Regulatory Roles of Tumor Necrosis Factor-α-Induced Protein 8 Like-Protein 2 in Inflammation, Immunity and Cancers: A Review. PMID:33364825
Malignancy and IFITM3: Friend or Foe? PMID:33364194
Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases. PMID:33363699
Severe Acute Respiratory Syndrome Coronavirus 2-Induced Neurological Complications. PMID:33363165
PD-L1 Is a Tumor Suppressor in Aggressive Endometrial Cancer Cells and Its Expression Is Regulated by miR-216a and lncRNA MEG3. PMID:33363153
Profiling of H3K27Ac Reveals the Influence of Asthma on the Epigenome of the Airway Epithelium. PMID:33362848
From miRNA Target Gene Network to miRNA Function: miR-375 Might Regulate Apoptosis and Actin Dynamics in the Heart Muscle via Rho-GTPases-Dependent Pathways. PMID:33352947
The Role of Connexin 43 in Lung Disease. PMID:33352732
The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells. PMID:33351855
Coronavirus genomes carry the signatures of their habitats. PMID:33351847
Attenuated CSF-1R signalling drives cerebrovascular pathology. PMID:33350588
Biological characteristics of aging in human acute myeloid leukemia cells: the possible importance of aldehyde dehydrogenase, the cytoskeleton and altered transcriptional regulation. PMID:33349623
Tumors Widely Express Hundreds of Embryonic Germline Genes. PMID:33348709
Chemical carcinogen-induced rat mammary carcinogenesis is a potential model of p21-activated kinase positive female breast cancer. PMID:33346690
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2. PMID:33344479
Smell and Taste in Severe CoViD-19: Self-Reported vs. Testing. PMID:33344476
Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer. PMID:33342045
Parameterization of Microsomal and Cytosolic Scaling Factors: Methodological and Biological Considerations for Scalar Derivation and Validation. PMID:33340340
Prognostic relevance of programmed cell death 1 ligand 2 (PDCD1LG2/PD-L2) in patients with advanced stage colon carcinoma treated with chemotherapy. PMID:33339860
The lncRNA Toolkit: Databases and In Silico Tools for lncRNA Analysis. PMID:33339309
GSK3α: An Important Paralog in Neurodegenerative Disorders and Cancer. PMID:33339170
Decreasing the Susceptibility of Malignant Cells to Infection Does Not Impact the Overall Efficacy of Myxoma Virus-Based Oncolytic Virotherapy. PMID:33335977
Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING? PMID:33335532
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. PMID:33333007
Systemic transcriptome comparison between early- And late-onset pre-eclampsia shows distinct pathology and novel biomarkers. PMID:33332660
Liver Disease and Coronavirus Disease 2019: From Pathogenesis to Clinical Care. PMID:33332624
Functional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming. PMID:33330447
Increased NFATC4 Correlates With Poor Prognosis of AML Through Recruiting Regulatory T Cells. PMID:33329712
Identification of Interleukin-9 Producing Immune Cells in Endometrial Carcinoma and Establishment of a Prognostic Nomogram. PMID:33329510
Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System. PMID:33328896
PKBβ/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors. PMID:33328589
IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates. PMID:33324675
Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms. PMID:33322668
Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction. PMID:33322162
Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2. PMID:33320095
Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling. PMID:33319173
Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. PMID:33318207
Expression of PAWR predicts prognosis of ovarian cancer. PMID:33317551
A bioinformatics analysis on the potential role of ACE2 in cardiac impairment of patients with coronavirus disease 2019. PMID:33313148
ATP13A3 is a major component of the enigmatic mammalian polyamine transport system. PMID:33310703
Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time. PMID:33307245
Systematic Comparison of Vesicular Targeting Signals Leads to the Development of Genetically Encoded Vesicular Fluorescent Zn2+ and pH Sensors. PMID:33305939
PathExt: a general framework for path-based mining of omics-integrated biological networks. PMID:33305329
Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture. PMID:33304744
Mass Spectral Analysis of Synthetic Peptides: Implications in Proteomics. PMID:33304200
Rho-GTPase pathways may differentiate treatment response to TNF-alpha and IL-17A inhibitors in psoriatic arthritis. PMID:33303908
Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro. PMID:33303781
A Multi-Strategy Sequencing Workflow in Inherited Retinal Dystrophies: Routine Diagnosis, Addressing Unsolved Cases and Candidate Genes Identification. PMID:33302505
Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke. PMID:33301355
Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma. PMID:33300568
Identification of SRSF10 as a regulator of SMN2 ISS-N1. PMID:33300159
Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin. PMID:33300026
Genetic Diversity of the Noncoding Control Region of the Novel Human Polyomaviruses. PMID:33297530
The complex role of prostaglandin E2-EP receptor signaling in wound healing. PMID:33296281
Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease. PMID:33294859
A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury. PMID:33294858
Prognostic and Predictive Value of a 15 Transcription Factors (TFs) Panel for Hepatocellular Carcinoma. PMID:33293862
SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling. PMID:33293473
Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development. PMID:33292279
Assessing immune infiltration and the tumor microenvironment for the diagnosis and prognosis of sarcoma. PMID:33292275
Network and Evolutionary Analysis of Human Epigenetic Regulators to Unravel Disease Associations. PMID:33291839
Prospects for Using Expression Patterns of Paramyxovirus Receptors as Biomarkers for Oncolytic Virotherapy. PMID:33291506
Proteomic Study Identifies Glycolytic and Inflammation Pathways Involved in Recurrent Otitis Media. PMID:33291465
Proteomic signatures of 16 major types of human cancer reveal universal and cancer-type-specific proteins for the identification of potential therapeutic targets. PMID:33287876
The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma. PMID:33287763
Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring-An Inactive Enzyme with Intact Substrate Binding. PMID:33287293
Overexpression of TPX2 predicts poor clinical outcome and is associated with immune infiltration in hepatic cell cancer. PMID:33285774
Clinical Correlates of the NR3C1 Gene Methylation at Various Stages of Psychosis. PMID:33284958
Options for COVID-19 Entry into Pulmonary Cells. PMID:33283173
Effect of EGLN1 Genetic Polymorphisms on Hemoglobin Concentration in Andean Highlanders. PMID:33282944
Machine Learning Based Network Analysis Determined Clinically Relevant miRNAs in Breast Cancer. PMID:33281885
Expression of ATP/GTP Binding Protein 1 Has Prognostic Value for the Clinical Outcomes in Non-Small Cell Lung Carcinoma. PMID:33276627
Complex genetic dependencies among growth and neurological phenotypes in healthy children: Towards deciphering developmental mechanisms. PMID:33270668
The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer. PMID:33270085
A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation. PMID:33268789
Human Cytomegalovirus Induces the Expression of the AMPKa2 Subunit to Drive Glycolytic Activation and Support Productive Viral Infection. PMID:33268515
Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types. PMID:33266506
Machine Learning Identifies Robust Matrisome Markers and Regulatory Mechanisms in Cancer. PMID:33266472
The ADAR Family in Amphioxus: RNA Editing and Conserved Orthologous Site Predictions. PMID:33265998
Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins. PMID:33263282
Acute appendicitis in four children with SARS-CoV-2 infection. PMID:33262930
Bioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium. PMID:33262348
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import. PMID:33262325
Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer. PMID:33262136
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study. PMID:33261667
Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium. PMID:33256374
The G-Protein Coupled Formyl Peptide Receptors and Their Role in the Progression of Digestive Tract Cancer. PMID:33251986
Spatial Proteomic Approach to Characterize Skeletal Muscle Myofibers. PMID:33251806
Identification of potential biomarkers for lung adenocarcinoma. PMID:33251353
Serum RNA Profiling in the 10-Years Period Prior to Diagnosis of Testicular Germ Cell Tumor. PMID:33251139
On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. PMID:33246953
Missense variants in the N-terminal domain of the A isoform of FHF2/FGF13 cause an X-linked developmental and epileptic encephalopathy. PMID:33245860
PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2). PMID:33245768
Molecular Basis of Cardiac and Vascular Injuries Associated With COVID-19. PMID:33240937
Multiple functions of TBCK protein in neurodevelopment disorders and tumors. PMID:33240423
Identifying transcriptomic correlates of histology using deep learning. PMID:33237966
COVID-19 endocrinopathy with hindsight from SARS. PMID:33236920
Skin tape stripping identifies gene transcript signature associated with allergic contact dermatitis. PMID:33236775
Review of COVID-19 and male genital tract. PMID:33236375
Proteomics analysis of serum small extracellular vesicles for the longitudinal study of a glioblastoma multiforme mouse model. PMID:33235327
Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network. PMID:33234678
SARS-CoV-2 attachment to host cells is possibly mediated via RGD-integrin interaction in a calcium-dependent manner and suggests pulmonary EDTA chelation therapy as a novel treatment for COVID 19. PMID:33232865
BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. PMID:33232675
Upregulation of KIF20A promotes tumor proliferation and invasion in renal clear cell carcinoma and is associated with adverse clinical outcome. PMID:33232285
Top-down proteomics: challenges, innovations, and applications in basic and clinical research. PMID:33232185
PINA 3.0: mining cancer interactome. PMID:33231689
Downstream Neighbor of SON (DONSON) Expression Is Enhanced in Phenotypically Aggressive Prostate Cancers. PMID:33228112
The value of a metabolic reprogramming-related gene signature for pancreatic adenocarcinoma prognosis prediction. PMID:33226369
Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-Mediated ARDS. PMID:33214479
Obesity Represses CYP2R1, the Vitamin D 25-Hydroxylase, in the Liver and Extrahepatic Tissues. PMID:33210060
Expression and role of nuclear receptor-interacting protein 1 (NRIP1) in stomach adenocarcinoma. PMID:33209873
Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota. PMID:33208821
Altered Tissue and Plasma Levels of Fibroblast Activation Protein-α (FAP) in Renal Tumours. PMID:33207686
Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva. PMID:33207190
The IMEx coronavirus interactome: an evolving map of Coronaviridae-host molecular interactions. PMID:33206959
The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer. PMID:33205077
Urinary glycoproteins associated with aggressive prostate cancer. PMID:33204318
Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling. PMID:33203841
Genetic Predictors of Severe Skin Toxicity in Patients with Stage III Colon Cancer Treated with Cetuximab: NCCTG N0147 (Alliance). PMID:33203692
Targeting the renin-angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges. PMID:33203679
The 40bp Indel Polymorphism rs150550023 in the MDM2 Promoter is Associated with Intriguing Shifts in Gene Expression in the p53-MDM2 Regulatory Hub. PMID:33202864
Combined liver-kidney transplantation for rare diseases. PMID:33200012
Identification of a New QTL Region on Mouse Chromosome 1 Responsible for Male Hypofertility: Phenotype Characterization and Candidate Genes. PMID:33198087
A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project. PMID:33197228
Colitis-induced IL11 promotes colon carcinogenesis. PMID:33196831
The Pursuit of COVID-19 Biomarkers: Putting the Spotlight on ACE2 and TMPRSS2 Regulatory Sequences. PMID:33195331
Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery. PMID:33195264
Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment. PMID:33194695
Integration of Online Omics-Data Resources for Cancer Research. PMID:33193699
TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019. PMID:33193689
Theoretical and in silico Analyses Reveal MYC as a Dynamic Network Biomarker in Colon and Rectal Cancer. PMID:33193630
Identification of Prognostic Markers in Cholangiocarcinoma Using Altered DNA Methylation and Gene Expression Profiles. PMID:33193605
Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology. PMID:33191914
Bioinformatics analysis reveals TSPAN1 as a candidate biomarker of progression and prognosis in pancreatic cancer. PMID:33188589
Prognostic roles of metabolic reprogramming-associated genes in patients with hepatocellular carcinoma. PMID:33188160
Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker. PMID:33187367
Systematic comparison and assessment of RNA-seq procedures for gene expression quantitative analysis. PMID:33184454
Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice. PMID:33184425
Role of miRNAs in Sigmoid Colon Cancer: A Search for Potential Biomarkers. PMID:33182525
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4. PMID:33182504
Influence of Lipoxygenase Inhibition on Glioblastoma Cell Biology. PMID:33182324
EZH2 is a negative prognostic biomarker associated with immunosuppression in hepatocellular carcinoma. PMID:33180829
Comprehensive mapping of the human cytokine gene regulatory network. PMID:33179750
Comprehensive bioinformatics analysis of the TP53 signaling pathway in Wilms' tumor. PMID:33178760
α2-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling. PMID:33178692
Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19. PMID:33177848
Targeting receptor complexes: a new dimension in drug discovery. PMID:33177699
Prognosis prediction model for conversion from mild cognitive impairment to Alzheimer's disease created by integrative analysis of multi-omics data. PMID:33172501
Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta. PMID:33171905
Microbubbles Cloaked with Hydrogels as Activatable Ultrasound Contrast Agents. PMID:33170637
Enhanced Validation of Antibodies Enables the Discovery of Missing Proteins. PMID:33170010
Synergy of melanin and vitamin-D may play a fundamental role in preventing SARS-CoV-2 infections and halt COVID-19 by inactivating furin protease. PMID:33169107
Deciphering cell-cell interactions and communication from gene expression. PMID:33168968
COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics. PMID:33166390
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities. PMID:33164751
CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A. PMID:33163493
The role of transcription factor caudal-related homeobox transcription factor 2 in colorectal cancer. PMID:33163374
Discovery, validation and sequencing of urinary peptides for diagnosis of liver fibrosis-A multicentre study. PMID:33160210
Genetic and epigenetic factors determining NAFLD risk. PMID:33160101
Cardiac and Vascular α1-Adrenoceptors in Congestive Heart Failure: A Systematic Review. PMID:33158106
The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma. PMID:33154775
Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin. PMID:33154365
Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A. PMID:33152346
Multi-kinase framework promotes proliferation and invasion of lung adenocarcinoma through activation of dynamin-related protein 1. PMID:33152171
LINC00968 can inhibit the progression of lung adenocarcinoma through the miR-21-5p/SMAD7 signal axis. PMID:33147570
The Human Protein Atlas-Spatial localization of the human proteome in health and disease. PMID:33146890
Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment. PMID:33146700
Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype. PMID:33142937
BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling. PMID:33142801
Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage. PMID:33140861
Functional module detection through integration of single-cell RNA sequencing data with protein-protein interaction networks. PMID:33138772
Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations. PMID:33138277
The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits. PMID:33137877
PlacentaCellEnrich: A tool to characterize gene sets using placenta cell-specific gene enrichment analysis. PMID:33137644
On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins. PMID:33136379
Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa. PMID:33133517
A Transcriptomics-Based Meta-Analysis Combined With Machine Learning Identifies a Secretory Biomarker Panel for Diagnosis of Pancreatic Adenocarcinoma. PMID:33133160
Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models. PMID:33131247
The Complexity and Dynamics of the Tissue Glycoproteome Associated With Prostate Cancer Progression. PMID:33127837
Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19. PMID:33123533
Prognosis Analysis and Validation of m6A Signature and Tumor Immune Microenvironment in Glioma. PMID:33123464
SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer. PMID:33122723
Screening and identification of key genes and pathways in metastatic uveal melanoma based on gene expression using bioinformatic analysis. PMID:33120861
Increased E2F2 predicts poor prognosis in patients with HCC based on TCGA data. PMID:33115417
Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma. PMID:33114768
CCL18 in the Progression of Cancer. PMID:33114763
The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease. PMID:33114658
Highly Multiplexed Single-Cell In Situ RNA and DNA Analysis by Consecutive Hybridization. PMID:33113917
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2. PMID:33112891
Genetic predisposition to neural crest-derived tumors: revisiting the role of KIF1B. PMID:33112832
An integrated autophagy-related gene signature predicts prognosis in human endometrial Cancer. PMID:33109128
O-Pair Search with MetaMorpheus for O-glycopeptide characterization. PMID:33106676
Activatable Zymography Probes Enable In Situ Localization of Protease Dysregulation in Cancer. PMID:33106334
Voltage-Gated Calcium Channels in Nonexcitable Tissues. PMID:33106102
Three-gene prognostic biomarkers for seminoma identified by weighted gene co-expression network analysis. PMID:33104706
Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma. PMID:33103995
Protein-driven mechanism of multiorgan damage in COVID-19. PMID:33103107
Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis. PMID:33102693
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition. PMID:33101674
Whole Genome Sequence Data Provides Novel Insights Into the Genetic Architecture of Meat Quality Traits in Beef. PMID:33101375
Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of human NHE3 regulating its expression and activity. PMID:33095475
Genome-Wide Co-Expression Distributions as a Metric to Prioritize Genes of Functional Importance. PMID:33092259
Neurobiological origins of individual differences in mathematical ability. PMID:33090992
Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers. PMID:33087697
PLA2G6 guards placental trophoblasts against ferroptotic injury. PMID:33087576
Differential gene regulatory pattern in the human brain from schizophrenia using transcriptomic-causal network. PMID:33087039
The COVID-19 Pandemic from a Human Genetic Perspective. PMID:33084340
Improved detection of tumor suppressor events in single-cell RNA-Seq data. PMID:33083012
Base editing: advances and therapeutic opportunities. PMID:33077937
PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. PMID:33077911
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands. PMID:33076281
Understand variability of COVID-19 through population and tissue variations in expression of SARS-CoV-2 host genes. PMID:33072849
Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney. PMID:33072769
ABC Exporters in Pathogenesis: Role of Synthetic Anti-Microbial Peptides. PMID:33068233
A high-stringency blueprint of the human proteome. PMID:33067450
Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patients. PMID:33061814
Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C. PMID:33060297
Use of patient derived urine renal epithelial cells to confirm pathogenicity of PKHD1 alleles. PMID:33059616
GNG13 Is a Potential Marker of the State of Health of Alzheimer's Disease Patients' Cerebellum. PMID:33057964
Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours? PMID:33057948
Application of small molecule FPR1 antagonists in the treatment of cancers. PMID:33057069
Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies. PMID:33053333
Non-permissive SARS-CoV-2 infection in human neurospheres. PMID:33052345
Protein-protein and protein-nucleic acid binding residues important for common and rare sequence variants in human. PMID:33050876
p38 MAPK Pathway in the Heart: New Insights in Health and Disease. PMID:33049962
Stearoyl-CoA desaturase 5 (SCD5), a Δ-9 fatty acyl desaturase in search of a function. PMID:33049404
CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia. PMID:33046866
INTEDE: interactome of drug-metabolizing enzymes. PMID:33045737
Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis. PMID:33045259
SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidney disease. PMID:33038424
Src Family Protein Kinase Controls the Fate of B Cells in Autoimmune Diseases. PMID:33037966
ATP-Binding and Hydrolysis in Inflammasome Activation. PMID:33036374
Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes in vitro. PMID:33034335
PRELP has prognostic value and regulates cell proliferation and migration in hepatocellular carcinoma. PMID:33033521
Acyl-CoA synthetases as regulators of brain phospholipid acyl-chain diversity. PMID:33031993
Molecular Pathways Linking Oxylipins to Nociception in Rats. PMID:33031942
Tissue distributions of antiviral drugs affect their capabilities of reducing viral loads in COVID-19 treatment. PMID:33031797
Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer. PMID:33030783
Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age. PMID:33029858
Cholesterol-Induced Phenotypic Modulation of Smooth Muscle Cells to Macrophage/Fibroblast-like Cells Is Driven by an Unfolded Protein Response. PMID:33028096
Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis. PMID:33025553
MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis. PMID:33025009
Computational assessment of MCM2 transcriptional expression and identification of the prognostic biomarker for human breast cancer. PMID:33024849
A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer. PMID:33024794
Benchmarking evolutionary tinkering underlying human-viral molecular mimicry shows multiple host pulmonary-arterial peptides mimicked by SARS-CoV-2. PMID:33024578
The Glycoprotease CpaA Secreted by Medically Relevant Acinetobacter Species Targets Multiple O-Linked Host Glycoproteins. PMID:33024038
Modeling tissue-relevant Caenorhabditis elegans metabolism at network, pathway, reaction, and metabolite levels. PMID:33022146
An analysis of tissue-specific alternative splicing at the protein level. PMID:33017396
G-Quadruplex Helicase DHX36/G4R1 Engages Nuclear Lamina Proteins in Quiescent Breast Cancer Cells. PMID:33015511
Comprehensive Analysis of the Expression, Relationship to Immune Infiltration and Prognosis of TIM-1 in Cancer. PMID:33014768
COVID-19: Proposing a Ketone-Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm. PMID:33014275
Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases. PMID:33014146
Identification of a Novel Immune-Related Prognostic Biomarker and Small-Molecule Drugs in Clear Cell Renal Cell Carcinoma (ccRCC) by a Merged Microarray-Acquired Dataset and TCGA Database. PMID:33014010
Causal Effects of Genetically Determined Metabolites on Risk of Polycystic Ovary Syndrome: A Mendelian Randomization Study. PMID:33013699
Functions of p38 MAP Kinases in the Central Nervous System. PMID:33013322
Prognostic Score-based Clinical Factors and Metabolism-related Biomarkers for Predicting the Progression of Hepatocellular Carcinoma. PMID:33013158
Cancer diagnostics based on plasma protein biomarkers: hard times but great expectations. PMID:33012111
COVID-19 and multiorgan failure: A narrative review on potential mechanisms. PMID:33011887
Identification of prognostic biomarkers and correlations with immune infiltrates among cGAS-STING in hepatocellular carcinoma. PMID:33006365
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. PMID:33004675
The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process. PMID:33003328
Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19. PMID:33000221
High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner. PMID:32999402
Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19. PMID:32998512
Renin Angiotensin System, COVID-19 and Male Fertility: Any Risk for Conceiving? PMID:32998451
Stable gene expression for normalisation and single-sample scoring. PMID:32997146
The authors reply: Comment on "The expression landscape of cachexia-inducing factors in human cancers" by Freire et al. PMID:32996709
Extracellular vesicles in patients in the acute phase of psychosis and after clinical improvement: an explorative study. PMID:32995075
Selenium and selenoproteins in viral infection with potential relevance to COVID-19. PMID:32992282
The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion. PMID:32989016
8p11.23 Amplification in Breast Cancer: Molecular Characteristics, Prognosis and Targeted Therapy. PMID:32987805
Expanded Chinese hamster organ and cell line proteomics profiling reveals tissue-specific functionalities. PMID:32985598
Cell-Type-Specific Proteogenomic Signal Diffusion for Integrating Multi-Omics Data Predicts Novel Schizophrenia Risk Genes. PMID:32984858
The spectrum of biochemical alterations associated with organ dysfunction and inflammatory status and their association with disease outcomes in severe COVID-19: A longitudinal cohort and time-series design study. PMID:32984786
Quantitative systems pharmacology and the personalized drug-microbiota-diet axis. PMID:32984662
The Construction of Bone Metastasis-Specific Prognostic Model and Co-expressed Network of Alternative Splicing in Breast Cancer. PMID:32984314
Identification of Clinically Significant Prostate Cancer by Combined PCA3 and AMACR mRNA Detection in Urine Samples. PMID:32984088
Complement C7 (C7), a Potential Tumor Suppressor, Is an Immune-Related Prognostic Biomarker in Prostate Cancer (PC). PMID:32984006
Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques. PMID:32979349
Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease. PMID:32978267
PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin. PMID:32978259
Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries. PMID:32973800
Maternal-fetal genetic interactions, imprinting, and risk of placental abruption. PMID:32972274
Comprehensive analysis on the expression levels and prognostic values of LOX family genes in kidney renal clear cell carcinoma. PMID:32970930
A Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action. PMID:32970276
Bioinformatics analysis and experimental validation of TTK as a biomarker for prognosis in non-small cell lung cancer. PMID:32969465
Identification of diagnostic and prognostic biomarkers, and candidate targeted agents for hepatitis B virus-associated early stage hepatocellular carcinoma based on RNA-sequencing data. PMID:32968453
T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration. PMID:32968060
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19. PMID:32966765
BCAS2, a protein enriched in advanced prostate cancer, interacts with NBS1 to enhance DNA double-strand break repair. PMID:32963349
Hypoketotic hypoglycemia in citrin deficiency: a case report. PMID:32962675
Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines. PMID:32961074
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency. PMID:32960813
Distinct peripheral blood monocyte and neutrophil transcriptional programs following intracerebral hemorrhage and different etiologies of ischemic stroke. PMID:32960689
In the blood: biomarkers for amyloid pathology and neurodegeneration in Alzheimer's disease. PMID:32954304
Designing custom CRISPR libraries for hypothesis-driven drug target discovery. PMID:32952937
Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption. PMID:32947816
Genetic Polymorphisms in Multispecific Transporters Mitigate Mercury Nephrotoxicity in an Artisanal and Small-Scale Gold Mining Community in Colombia. PMID:32946573
FOXL1 Regulates Lung Fibroblast Function via Multiple Mechanisms. PMID:32946266
PAWER: protein array web exploreR. PMID:32942983
UPLC-qTOF-MS Phytochemical Profile and Antiulcer Potential of Cyperus conglomeratus Rottb. Alcoholic Extract. PMID:32942704
Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate. PMID:32939018
Breaking Bottlenecks for the TCR Therapy of Cancer. PMID:32937956
Using Deep Learning to Extrapolate Protein Expression Measurements. PMID:32937025
Consistency and variation of protein subcellular location annotations. PMID:32935893
Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin's lymphoma to many other types of solid cancers. PMID:32934776
TMEM206 is a potential prognostic marker of hepatocellular carcinoma. PMID:32934741
Prognostic effects of the expression of inhibitor of DNA-binding family members on patients with lung adenocarcinoma. PMID:32934711
Effects of the Delta Opioid Receptor Agonist DADLE in a Novel Hypoxia-Reoxygenation Model on Human and Rat-Engineered Heart Tissue: A Pilot Study. PMID:32932811
An era of single-cell genomics consortia. PMID:32929222
Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism. PMID:32927708
Prospective evaluation of the lymph node proteome in dogs with multicentric lymphoma supplemented with sulforaphane. PMID:32926463
Pinpointing Cell Identity in Time and Space. PMID:32923457
Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models. PMID:32923168
The Landscape of CAR-T Cell Clinical Trials against Solid Tumors-A Comprehensive Overview. PMID:32916883
Proteome-wide Changes in the mdx-4cv Spleen due to Pathophysiological Cross Talk with Dystrophin-Deficient Skeletal Muscle. PMID:32916630
A Quantitative Proteome Map of the Human Body. PMID:32916130
Intestinal Receptor of SARS-CoV-2 in Inflamed IBD Tissue Seems Downregulated by HNF4A in Ileum and Upregulated by Interferon Regulating Factors in Colon. PMID:32915959
Cell type-specific genetic regulation of gene expression across human tissues. PMID:32913075
The Stress-Like Cancer Cell State Is a Consistent Component of Tumorigenesis. PMID:32910905
SLC25A51 is a mammalian mitochondrial NAD+ transporter. PMID:32906142
SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation. PMID:32905556
Regulation of the mitochondrial permeability transition pore and its effects on aging. PMID:32904375
CAR T Cell Therapy for Pediatric Brain Tumors. PMID:32903405
Integration of molecular profiles in a longitudinal wellness profiling cohort. PMID:32900998
Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton's Jelly-Derived Mesenchymal Stem Cells. PMID:32899389
Age-related copy number variations and expression levels of F-box protein FBXL20 predict ovarian cancer prognosis. PMID:32898767
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases. PMID:32895551
Targeting UDP-glucose dehydrogenase inhibits ovarian cancer growth and metastasis. PMID:32893977
GAB2 and GAB3 are expressed in a tumor stage-, grade- and histotype-dependent manner and are associated with shorter progression-free survival in ovarian cancer. PMID:32888136
Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain. PMID:32887883
Lipid Phosphate Phosphatases and Cancer. PMID:32887262
Genome-wide association study for circulating fibroblast growth factor 21 and 23. PMID:32884031
EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data. PMID:32883324
Thioredoxin-Related Transmembrane Proteins: TMX1 and Little Brothers TMX2, TMX3, TMX4 and TMX5. PMID:32878123
Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling. PMID:32876046
Fractional diffusion on the human proteome as an alternative to the multi-organ damage of SARS-CoV-2. PMID:32872802
Single-cell metabolic profiling of human cytotoxic T cells. PMID:32868913
Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. PMID:32867764
Plasma protein-based signature predicts distant metastasis and induction chemotherapy benefit in Nasopharyngeal Carcinoma. PMID:32863958
Central neurological complications and potential neuropathogenesis of COVID-19. PMID:32860569
microRNAs and Corresponding Targets Involved in Metastasis of Colorectal Cancer in Preclinical In Vivo Models. PMID:32859626
Genetically raised serum bilirubin levels and lung cancer: a cohort study and Mendelian randomisation using UK Biobank. PMID:32855344
Novel insights into the disease transcriptome of human diabetic glomeruli and tubulointerstitium. PMID:32853351
Learning the properties of adaptive regions with functional data analysis. PMID:32853200
Cellular diversity of the regenerating caudal fin. PMID:32851162
A Quantitative Analysis of Cellular Lipid Compositions During Acute Proteotoxic ER Stress Reveals Specificity in the Production of Asymmetric Lipids. PMID:32850859
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Colon Adenocarcinoma Metastasis. PMID:32850813
Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection. PMID:32850483
LC3-Associated Phagocytosis (LAP): A Potentially Influential Mediator of Efferocytosis-Related Tumor Progression and Aggressiveness. PMID:32850405
Low Expression of Claudin-7 as Potential Predictor of Distant Metastases in High-Grade Serous Ovarian Carcinoma Patients. PMID:32850397
Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells. PMID:32850342
Leveraging Public Single-Cell and Bulk Transcriptomic Datasets to Delineate MAIT Cell Roles and Phenotypic Characteristics in Human Malignancies. PMID:32849590
The Endosomal Recycling Pathway-At the Crossroads of the Cell. PMID:32842549
DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas. PMID:32838940
Clustering analysis of tumor metabolic networks. PMID:32838750
Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. PMID:32838361
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. PMID:32832599
The intermembrane space protein Mix23 is a novel stress-induced mitochondrial import factor. PMID:32826315
Proteomic Analysis of Exosomes for Discovery of Protein Biomarkers for Prostate and Bladder Cancer. PMID:32825017
Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells. PMID:32823874
A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions. PMID:32822567
SRSF1 regulates exosome microRNA enrichment in human cancer cells. PMID:32819370
Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris. PMID:32817591
Multiomic blood correlates of genetic risk identify presymptomatic disease alterations. PMID:32817414
Tracking the carbons supplying gluconeogenesis. PMID:32817317
Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner. PMID:32816606
Favorable therapeutic response after anti-Mesothelin antibody-drug conjugate treatment requires high expression of Mesothelin in tumor cells. PMID:32815024
Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt. PMID:32814826
Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets. PMID:32814578
The mitochondrial transcription machinery genes are upregulated in acute myeloid leukemia and associated with poor clinical outcome. PMID:32812906
Enzymatic Noncovalent Synthesis. PMID:32812754
Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation. PMID:32812257
An Exploration of Social Cognition in Children with Different Degrees of Genetic Deletion in Williams Syndrome. PMID:32812194
Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis? PMID:32811540
GFAP at 50. PMID:32811163
Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips. PMID:32807988
The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer. PMID:32802887
When Is an In Silico Representation a Digital Twin? A Biopharmaceutical Industry Approach to the Digital Twin Concept. PMID:32797270
Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks. PMID:32796035
The methylation status of the chemerin promoter region located from - 252 to + 258 bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels. PMID:32792625
Guinea pig cytomegalovirus trimer complex gH/gL/gO uses PDGFRA as universal receptor for cell fusion and entry. PMID:32791352
SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule. PMID:32791255
Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion. PMID:32790176
Combining Gene-Disease Associations with Single-Cell Gene Expression Data Provides Anatomy-Specific Subnetworks in Age-Related Macular Degeneration. PMID:32789304
The prognostic value of HGF-c-MET signaling pathway in Gastric Cancer: a study based on TCGA and GEO databases. PMID:32788873
Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane. PMID:32788342
Snca-GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding. PMID:32788297
COVID-19 and comorbidities: Deleterious impact on infected patients. PMID:32788073
Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility. PMID:32785227
C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients with Gestational Diabetes Mellitus: A Case-Control Study. PMID:32785102
Expression and clinical significance of methyl-CpG binding domain protein 2 in high-grade serous ovarian cancer. PMID:32782591
Identification of a five-gene signature for predicting the progression and prognosis of stage I endometrial carcinoma. PMID:32782557
Integrative Genomic Analysis Reveals Four Protein Biomarkers for Platelet Traits. PMID:32781905
Characterization of the different oligomeric states of the DAN family antagonists SOSTDC1 and SOST. PMID:32779697
Building the vertebrate codex using the gene breaking protein trap library. PMID:32779569
Presence of SARS-Coronavirus-2 in the Ileal Mucosa: Another Evidence for Infection of GI Tract by This Virus. PMID:32777284
Gene expression of the IGF hormones and IGF binding proteins across time and tissues in a model reptile. PMID:32776803
FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease. PMID:32776417
Expression of smooth muscle-like effectors and core cardiomyocyte regulators in the contractile papillae of Ciona. PMID:32774829
Discovery and validation of surface N-glycoproteins in MM cell lines and patient samples uncovers immunotherapy targets. PMID:32771993
TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion. PMID:32767843
Identification of the association between HMMR expression and progression of hepatocellular carcinoma via construction of a co-expression network. PMID:32765791
Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice. PMID:32764719
Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence. PMID:32764696
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front. PMID:32763154
Genome-wide methylation patterns predict clinical benefit of immunotherapy in lung cancer. PMID:32762727
Association of WNT7B and RSPO1 with Axial Length in School Children. PMID:32761137
Systems Biology Will Direct Vascular-Targeted Therapy for Obesity. PMID:32760294
Abnormal expression and prognostic significance of EPB41L1 in kidney renal clear cell carcinoma based on data mining. PMID:32760223
Bioinformatic Analysis of Correlation between Immune Infiltration and COVID-19 in Cancer Patients. PMID:32760213
Collagen Type III Alpha 1 chain regulated by GATA-Binding Protein 6 affects Type II IFN response and propanoate metabolism in the recurrence of lower grade glioma. PMID:32757451
Expression pattern, regulation, and clinical significance of TOX in breast cancer. PMID:32757053
Cerebral Immunohistochemical Characterization of the H2S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma. PMID:32754111
IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion. PMID:32753652
The Clinicopathological and Prognostic Significance of Nrf2 and Keap1 Expression in Hepatocellular Carcinoma. PMID:32751896
An overview of signaling pathways regulating YAP/TAZ activity. PMID:32748155
Integrative Omics Analyses Reveal Epigenetic Memory in Diabetic Renal Cells Regulating Genes Associated With Kidney Dysfunction. PMID:32747424
ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair. PMID:32744506
Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. PMID:32737331
Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer. PMID:32737302
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality. PMID:32737166
Molecular profiling of immune cell-enriched Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) interacting protein USP13. PMID:32735883
Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA. PMID:32735619
The Link Between the Mitochondrial Fatty Acid Oxidation Derangement and Kidney Injury. PMID:32733282
Systems Biology Approaches to Understand the Host-Microbiome Interactions in Neurodegenerative Diseases. PMID:32733199
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine. PMID:32730777
The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics. PMID:32728795
Occupancy maps of 208 chromatin-associated proteins in one human cell type. PMID:32728244
Lysosome-targeting chimaeras for degradation of extracellular proteins. PMID:32728216
Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer. PMID:32728173
Pyk2 Regulates Human Papillomavirus Replication by Tyrosine Phosphorylation of the E2 Protein. PMID:32727877
CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma. PMID:32727598
Multiple formin proteins participate in glioblastoma migration. PMID:32727404
The Interplay of Tumor Stroma and Translational Factors in Endometrial Cancer. PMID:32726992
Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer. PMID:32726752
Breed Differences in Dog Cognition Associated with Brain-Expressed Genes and Neurological Functions. PMID:32726413
In silico identification of the prognostic biomarkers and therapeutic targets associated with cancer stem cell characteristics of glioma. PMID:32725165
Mining the prognostic significance of the GINS2 gene in human breast cancer using bioinformatics analysis. PMID:32724372
Tumor Necrosis Factor Receptor SF10A (TNFRSF10A) SNPs Correlate With Corticosteroid Response in Duchenne Muscular Dystrophy. PMID:32719714
Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model. PMID:32719544
Insights into the skin of caecilian amphibians from gene expression profiles. PMID:32718305
Piggybacking on Classical Import and Other Non-Classical Mechanisms of Nuclear Import Appear Highly Prevalent within the Human Proteome. PMID:32718019
The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis. PMID:32717840
The protein expression profile of ACE2 in human tissues. PMID:32715618
Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease. PMID:32714578
Conventional protein kinase C in the brain: 40 years later. PMID:32714576
Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer's disease. PMID:32711556
Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD. PMID:32710014
Guarding the Genome: CENP-A-Chromatin in Health and Cancer. PMID:32708729
Chemokine Receptors CCR1 and CCR2 on Peripheral Blood Mononuclear Cells of Newly Diagnosed Patients with the CD38-Positive Chronic Lymphocytic Leukemia. PMID:32708233
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma. PMID:32707078
Downregulation of miR‑193a‑3p via targeting cyclin D1 in thyroid cancer. PMID:32705210
Transcriptomic comparison of human and mouse brain microvessels. PMID:32704093
Megalin/lipoprotein receptor-related protein 2 autoimmunity and kidney disease. PMID:32701075
Promoting crystallization of intrinsic membrane proteins with conjugated micelles. PMID:32699228
Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease. PMID:32696702
Artificial miRNAs targeting CAG repeat expansion in ORFs cause rapid deadenylation and translation inhibition of mutant transcripts. PMID:32696070
Analysis of m6A RNA methylation in Caenorhabditis elegans. PMID:32695436
Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours. PMID:32694827
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. PMID:32694731
FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation. PMID:32694203
Cellular Imprinting Proteomics Assay: A Novel Method for Detection of Neural and Ocular Disorders Applied to Congenital Zika Virus Syndrome. PMID:32686424
MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling. PMID:32681036
ECRG2, a novel transcriptional target of p53, modulates cancer cell sensitivity to DNA damage. PMID:32681017
Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines. PMID:32680547
Gene expression profiling identifies the role of Zac1 in cervical cancer metastasis. PMID:32678267
Secreted Frizzled-Related Protein 4 (SFRP4) Is an Independent Prognostic Marker in Prostate Cancers Lacking TMPRSS2: ERG Fusions. PMID:32677026
The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction. PMID:32670277
Brainstem Organoids From Human Pluripotent Stem Cells. PMID:32670003
A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells. PMID:32669955
Estimation of Hub Genes and Infiltrating Immune Cells in Non-Smoking Females with Lung Adenocarcinoma by Integrated Bioinformatic Analysis. PMID:32669531
Indication of Premelanosome Protein (PMEL) Expression Outside of Pigmented Bovine Skin Suggests Functions Beyond Eumelanogenesis. PMID:32668786
Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation. PMID:32667968
SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis. PMID:32664949
Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells. PMID:32664515
HRT Atlas v1.0 database: redefining human and mouse housekeeping genes and candidate reference transcripts by mining massive RNA-seq datasets. PMID:32663312
Enhancer-gene rewiring in the pathogenesis of Quebec platelet disorder. PMID:32663239
Metabolic Messengers: Adiponectin. PMID:32661510
New Insights on Genetic Diagnostics in Cardiomyopathy and Arrhythmia Patients Gained by Stepwise Exome Data Analysis. PMID:32659924
Chromatin network markers of leukemia. PMID:32657405
Abl1 deletion in gut stem cells suppresses p53 induction and promotes colitis-associated tumor formation. PMID:32652042
Endocrine Significance of SARS-CoV-2's Reliance on ACE2. PMID:32652001
Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury. PMID:32651223
Quantitative characterization of tumor cell-free DNA shortening. PMID:32650715
Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins. PMID:32647060
Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. PMID:32646997
Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome. PMID:32645919
Serine Incorporator 2 (SERINC2) Expression Predicts an Unfavorable Prognosis of Low-Grade Glioma (LGG): Evidence from Bioinformatics Analysis. PMID:32642801
CRISPR-based functional genomics for neurological disease. PMID:32641861
SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle. PMID:32641214
Clinical validation of the novel HDAC6 radiotracer [18F]EKZ-001 in the human brain. PMID:32638097
A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic. PMID:32637960
Systematic analysis reveals a functional role for STAMBPL1 in the epithelial-mesenchymal transition process across multiple carcinomas. PMID:32636467
Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury. PMID:32636391
Lipid Signaling in Ocular Neovascularization. PMID:32635437
Identification of miRNA Master Regulators in Breast Cancer. PMID:32635183
HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia. PMID:32634239
Variance-adjusted Mahalanobis (VAM): a fast and accurate method for cell-specific gene set scoring. PMID:32633778
Muscle-derived Myoglianin regulates Drosophila imaginal disc growth. PMID:32633716
Mitoribosome Defect in Hepatocellular Carcinoma Promotes an Aggressive Phenotype with Suppressed Immune Reaction. PMID:32629612
Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling. PMID:32629387
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections. PMID:32628701
Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits. PMID:32628676
Long-term ACE Inhibitor/ARB Use Is Associated With Severe Renal Dysfunction and Acute Kidney Injury in Patients With Severe COVID-19: Results From a Referral Center Cohort in the Northeast of France. PMID:32623470
A brief review of liver injury in patients with Corona Virus Disease-19 during the pandemic. PMID:32621206
Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome. PMID:32619492
The transcriptional signature associated with human motile cilia. PMID:32616903
ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins. PMID:32616830
Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies. PMID:32612606
Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular Pathology. PMID:32612540
Physiological blood-brain transport is impaired with age by a shift in transcytosis. PMID:32612231
Inhibition of Bruton's TK regulates macrophage NF-κB and NLRP3 inflammasome activation in metabolic inflammation. PMID:32608058
Candidate protein biomarkers in pancreatic neuroendocrine neoplasms grade 3. PMID:32606315
The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells. PMID:32603710
Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection. PMID:32602627
Proximity Ligation Assay as a Tool for Antibody Validation in Human Tissues. PMID:32602410
Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies. PMID:32601394
Profiling tear proteomes of patients with unilateral relapsed Behcet's disease-associated uveitis using data-independent acquisition proteomics. PMID:32596040
Analysis of Expression and Its Clinical Significance of the Secreted Phosphoprotein 1 in Lung Adenocarcinoma. PMID:32595698
High prevalence of plasma lipid abnormalities in human and canine Duchenne and Becker muscular dystrophies depicts a new type of primary genetic dyslipidemia. PMID:32593511
Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice†. PMID:32588889
DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer. PMID:32588770
The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions. PMID:32587962
Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development. PMID:32587777
COVID-19 pandemic: Its impact on liver disease and liver transplantation. PMID:32587443
Identification of Cell-Surface Proteins Endocytosed by Human Brain Microvascular Endothelial Cells In Vitro. PMID:32585920
Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters. PMID:32582958
cfNOMe - A single assay for comprehensive epigenetic analyses of cell-free DNA. PMID:32580754
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma. PMID:32579974
Profiling the circulating mRNA transcriptome in human liver disease. PMID:32577166
Regulation of cellular senescence by eukaryotic members of the FAH superfamily - A role in calcium homeostasis? PMID:32574647
The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence-associated epigenomic remodeling. PMID:32573059
Matriptase processing of APLP1 ectodomain alters its homodimerization. PMID:32572095
Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury. PMID:32571916
Conserved Small Nucleotidic Elements at the Origin of Concerted piRNA Biogenesis from Genes and lncRNAs. PMID:32570966
Identification of a Robust Five-Gene Risk Model in Prostate Cancer: A Robust Likelihood-Based Survival Analysis. PMID:32566639
A Sample Preparation Protocol for High Throughput Immunofluorescence of Suspension Cells on an Adherent Surface. PMID:32564662
Evidence for endothelial-to-mesenchymal transition in human brain arteriovenous malformations. PMID:32564509
Empagliflozin suppresses inflammation and protects against acute septic renal injury. PMID:32564182
Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis. PMID:32561683
Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn's Disease. PMID:32561494
Mapping of CaM, S100A1 and PIP2-Binding Epitopes in the Intracellular N- and C-Termini of TRPM4. PMID:32560560
Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target. PMID:32560530
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. PMID:32559194
Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2. PMID:32558639
Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis. PMID:32557728
Identification of important genes and drug repurposing based on clinical-centered analysis across human cancers. PMID:32555508
GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma. PMID:32555306
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. PMID:32554929
HDAC9 deficiency promotes tumor progression by decreasing the CD8+ dendritic cell infiltration of the tumor microenvironment. PMID:32554611
Apolipoprotein D. PMID:32554047
LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome. PMID:32553112
Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells. PMID:32552827
The effect of age on the microarchitecture and profile of gene expression in femoral head and neck bone from patients with osteoarthritis. PMID:32551338
Tissue-Specific Requirement for the GINS Complex During Zebrafish Development. PMID:32548116
Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor. PMID:32546533
The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly. PMID:32542055
Unveiling prognostics biomarkers of tyrosine metabolism reprogramming in liver cancer by cross-platform gene expression analyses. PMID:32542016
Dynamic rewiring of the human interactome by interferon signaling. PMID:32539747
Integrated Analyses Identify Immune-Related Signature Associated with Qingyihuaji Formula for Treatment of Pancreatic Ductal Adenocarcinoma Using Network Pharmacology and Weighted Gene Co-Expression Network. PMID:32537471
Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance. PMID:32536688
Why Great Mitotic Inhibitors Make Poor Cancer Drugs. PMID:32536592
PET Imaging of the Natural Killer Cell Activation Receptor NKp30. PMID:32532927
Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways. PMID:32526885
GOcats: A tool for categorizing Gene Ontology into subgraphs of user-defined concepts. PMID:32525872
Systematic Humanization of the Yeast Cytoskeleton Discerns Functionally Replaceable from Divergent Human Genes. PMID:32522745
Comprehensive analysis reveals a metabolic ten-gene signature in hepatocellular carcinoma. PMID:32518728
Severe chronic kidney disease environment reduced calcium-sensing receptor expression in parathyroid glands of adenine-induced rats even without high phosphorus diet. PMID:32517664
A framework for integrating directed and undirected annotations to build explanatory models of cis-eQTL data. PMID:32516306
Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice. PMID:32516134
The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer. PMID:32515734
Downexpression of HSD17B6 correlates with clinical prognosis and tumor immune infiltrates in hepatocellular carcinoma. PMID:32514254
SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease. PMID:32511461
Overexpressed gene signature of EPH receptor A/B family in cancer patients-comprehensive analyses from the public high-throughput database. PMID:32509099
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint. PMID:32508832
Tetraspanins in the regulation of mast cell function. PMID:32507938
Hepatic consequences of COVID-19 infection. Lapping or biting? PMID:32507608
Single-Cell RNA Sequencing of Human, Macaque, and Mouse Testes Uncovers Conserved and Divergent Features of Mammalian Spermatogenesis. PMID:32504559
Analysis of human metabolism by reducing the complexity of the genome-scale models using redHUMAN. PMID:32499584
Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned so Far. PMID:32498343
Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells. PMID:32492424
Tox21BodyMap: a webtool to map chemical effects on the human body. PMID:32491175
Decoding the Body Language of Immunity: Tackling the Immune System at the Organism Level. PMID:32490290
Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. PMID:32487735
Significance of STAT3 in Immune Infiltration and Drug Response in Cancer. PMID:32486001
Emerging Roles of Gemin5: From snRNPs Assembly to Translation Control. PMID:32485878
Age-Related Changes in Hair Shaft Protein Profiling and Genetically Variant Peptides. PMID:32485593
TRPM4 is overexpressed in breast cancer associated with estrogen response and epithelial-mesenchymal transition gene sets. PMID:32484822
The role of 3'UTR-protein complexes in the regulation of protein multifunctionality and subcellular localization. PMID:32484544
Partial proteolysis improves the identification of the extracellular segments of transmembrane proteins by surface biotinylation. PMID:32483232
Integrated omics in Drosophila uncover a circadian kinome. PMID:32483184
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor. PMID:32483149
Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation. PMID:32482897
Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia. PMID:32481505
Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens. PMID:32477965
Cardiac involvement in a cross-sectional cohort of myotonic dystrophies and other skeletal myopathies. PMID:32476276
Annexin A1 is a Potential Novel Biomarker of Congestion in Acute Heart Failure. PMID:32473378
Buccal Mucosa Biomarkers in Alzheimer's Disease. PMID:32468458
Endometrial profilin 1: a key player in embryo-endometrial crosstalk. PMID:32466630
Personalized whole-body models integrate metabolism, physiology, and the gut microbiome. PMID:32463598
Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors. PMID:32463365
Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases. PMID:32462403
Flexible Mixture Model Approaches That Accommodate Footprint Size Variability for Robust Detection of Balancing Selection. PMID:32462188
AKNA Is a Potential Prognostic Biomarker in Gastric Cancer and Function as a Tumor Suppressor by Modulating EMT-Related Pathways. PMID:32462010
Quantitative analysis of Y-Chromosome gene expression across 36 human tissues. PMID:32461223
Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma. PMID:32460791
Integration of Heterogeneous Experimental Data Improves Global Map of Human Protein Complexes. PMID:32457940
A Bitter Taste in Your Heart. PMID:32457649
The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target? PMID:32457627
Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding. PMID:32457219
The Role of Selected Chemokines and Their Receptors in the Development of Gliomas. PMID:32456359
MicrobioLink: An Integrated Computational Pipeline to Infer Functional Effects of Microbiome-Host Interactions. PMID:32455748
A bidirectional Mendelian randomization study supports causal effects of kidney function on blood pressure. PMID:32454124
Chemerin as a Driver of Hypertension: A Consideration. PMID:32453820
Identification of Tumor Antigens in the HLA Peptidome of Patient-derived Xenograft Tumors in Mouse. PMID:32451349
PseudoChecker: an integrated online platform for gene inactivation inference. PMID:32449938
Gene X environment: the cellular environment governs the transcriptional response to environmental chemicals. PMID:32448403
Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus. PMID:32447426
Glycoprotein nonmetastatic melanoma protein B: A key mediator and an emerging therapeutic target in autoimmune diseases. PMID:32445534
TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling. PMID:32444641
Human genetic dissection of papillomavirus-driven diseases: new insight into their pathogenesis. PMID:32435828
The CD47-SIRPα Immune Checkpoint. PMID:32433947
Genetic Determinants of Reduced Arsenic Metabolism Efficiency in the 10q24.32 Region Are Associated With Reduced AS3MT Expression in Multiple Human Tissue Types. PMID:32433756
Comprehensive analysis of the value of RAB family genes in prognosis of breast invasive carcinoma. PMID:32432324
Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability. PMID:32429325
Anti-vimentin, anti-TUFM, anti-NAP1L1 and anti-DPYSL2 nanobodies display cytotoxic effect and reduce glioblastoma cell migration. PMID:32426045
Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract. PMID:32425701
Secretome-Based Screening in Target Discovery. PMID:32425085
Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains. PMID:32424074
Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking. PMID:32423029
Rare Genetic Diseases: Nature's Experiments on Human Development. PMID:32422592
Progress, Challenges, and Surprises in Annotating the Human Genome. PMID:32421357
Machine Learning Supports Long Noncoding RNAs as Expression Markers for Endometrial Carcinoma. PMID:32420338
Ten-eleven translocation proteins and their role beyond DNA demethylation - what we can learn from the fly. PMID:32419604
A Fast and Memory-Efficient Spectral Library Search Algorithm Using Locality-Sensitive Hashing. PMID:32415809
Art and Science of the Cellular Mesoscale. PMID:32413324
Association between SNAP25 and human glioblastoma multiform: a comprehensive bioinformatic analysis. PMID:32412599
Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq. PMID:32410729
BAHD1 haploinsufficiency results in anxiety-like phenotypes in male mice. PMID:32407325
Identification of transforming growth factor beta induced (TGFBI) as an immune-related prognostic factor in clear cell renal cell carcinoma (ccRCC). PMID:32406866
Spatio-Temporal Roles of ASD-Associated Variants in Human Brain Development. PMID:32403330
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP. PMID:32402273
Urinary Extracellular Vesicles and Salt-Losing Tubulopathies: A Proteomic Approach. PMID:32397528
StanDep: Capturing transcriptomic variability improves context-specific metabolic models. PMID:32396573
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. PMID:32393898
The emerging roles of WBP2 oncogene in human cancers. PMID:32393834
Nucleoside Reverse Transcriptase Inhibitor Interaction with Human Equilibrative Nucleoside Transporters 1 and 2. PMID:32393653
Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors. PMID:32388565
Mantis-ml: Disease-Agnostic Gene Prioritization from High-Throughput Genomic Screens by Stochastic Semi-supervised Learning. PMID:32386536
Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes. PMID:32385057
Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. PMID:32382484
eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled. PMID:32381507
Identification and validation of the angiogenic genes for constructing diagnostic, prognostic, and recurrence models for hepatocellular carcinoma. PMID:32379058
Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation. PMID:32376919
Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 Adrenoceptors. PMID:32376421
Severe acute respiratory syndrome coronavirus 2 detection in the female lower genital tract. PMID:32376320
Integrative analyses of the RNA modification machinery reveal tissue- and cancer-specific signatures. PMID:32375858
MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth. PMID:32371956
A single-cell transcriptomic landscape of primate arterial aging. PMID:32371953
Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues. PMID:32371927
Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding. PMID:32369656
Towards the routine use of in silico screenings for drug discovery using metabolic modelling. PMID:32369553
Tryptophan catabolism reflects disease activity in human tuberculosis. PMID:32369456
Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation. PMID:32366865
TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. PMID:32366851
Proteomics illuminates fat as key tissue in aging. PMID:32366668
Cystathionine-β-Synthase: Molecular Regulation and Pharmacological Inhibition. PMID:32365821
A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development: IUPHAR Review 29. PMID:32358833
Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche. PMID:32354994
Is SARS-CoV-2 Also an Enteric Pathogen With Potential Fecal-Oral Transmission? A COVID-19 Virological and Clinical Review. PMID:32353371
TRP Channels as Emerging Therapeutic Targets for Neurodegenerative Diseases. PMID:32351395
Whole transcriptome analysis and validation of metabolic pathways in subcutaneous adipose tissues during FGF21-induced weight loss in non-human primates. PMID:32350364
Hepatocyte nuclear factor-4α regulates expression of the serotonin transporter in intestinal epithelial cells. PMID:32348179
T cell costimulation, checkpoint inhibitors and anti-tumor therapy. PMID:32345776
Shared genetic architecture and casual relationship between leptin levels and type 2 diabetes: large-scale cross-trait meta-analysis and Mendelian randomization analysis. PMID:32341051
Urinary Exosomal MicroRNA Signatures in Nephrotic, Biopsy-Proven Diabetic Nephropathy. PMID:32340338
Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression. PMID:32338600
The Oncogenic Role of CENPA in Hepatocellular Carcinoma Development: Evidence from Bioinformatic Analysis. PMID:32337237
Identification of genes involved in the evolution of human intelligence through combination of inter-species and intra-species genetic variations. PMID:32337102
Expression of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in the Gut of Patients With IBD. PMID:32333601
MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer. PMID:32332866
Adsorption of a styrene maleic acid (SMA) copolymer-stabilized phospholipid nanodisc on a solid-supported planar lipid bilayer. PMID:32330753
Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3. PMID:32330444
Translational genomics for achieving higher genetic gains in groundnut. PMID:32328677
Genetic Roadmap for Kidney Involvement of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. PMID:32327413
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression. PMID:32326089
Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis. PMID:32325894
Tissue-selective regulation of protein homeostasis and unfolded protein response signalling in sporadic ALS. PMID:32324341
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer. PMID:32322170
Consistent RNA sequencing contamination in GTEx and other data sets. PMID:32321923
Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population. PMID:32321463
Risks of ACE Inhibitor and ARB Usage in COVID-19: Evaluating the Evidence. PMID:32320478
SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines. PMID:32319594
Direct trafficking pathways from the Golgi apparatus to the plasma membrane. PMID:32317144
Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4. PMID:32316263
PDZ Domains as Drug Targets. PMID:32313833
Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection. PMID:32311451
GDF15: A Hormone Conveying Somatic Distress to the Brain. PMID:32310257
Functional Amyloids and their Possible Influence on Alzheimer Disease. PMID:32309597
Ribosomal protein RACK1 enhances translation of poliovirus and other viral IRESs. PMID:32308198
ALS-associated genes in SCA2 mouse spinal cord transcriptomes. PMID:32307524
Histone Deacetylases in Kidney Physiology and Acute Kidney Injury. PMID:32303277
Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia. PMID:32302554
Nitrogen Metabolism in Cancer and Immunity. PMID:32302552
Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes. PMID:32302527
Plasma membrane expression of G protein-coupled estrogen receptor (GPER)/G protein-coupled receptor 30 (GPR30) is associated with worse outcome in metachronous contralateral breast cancer. PMID:32302351
Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice†. PMID:32301969
NCAPG Is a Promising Therapeutic Target Across Different Tumor Types. PMID:32300299
Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers. PMID:32298395
The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling. PMID:32296774
PTHrP, A Biomarker for CNS Metastasis in Triple-Negative Breast Cancer and Selection for Adjuvant Chemotherapy in Node-Negative Disease. PMID:32296756
Transcriptome analysis revealed key prognostic genes and microRNAs in hepatocellular carcinoma. PMID:32296612
A WIZ/Cohesin/CTCF Complex Anchors DNA Loops to Define Gene Expression and Cell Identity. PMID:32294452
Molecular effects of dADD1 misexpression in chromatin organization and transcription. PMID:32293240
Dysregulation of Type II Transmembrane Serine Proteases and Ligand-Dependent Activation of MET in Urological Cancers. PMID:32290402
Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort. PMID:32290310
Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome. PMID:32286305
Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine. PMID:32284825
Meltome atlas-thermal proteome stability across the tree of life. PMID:32284610
Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease. PMID:32277752
Methionine Dependence of Cancer. PMID:32276408
Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis. PMID:32275865
Characteristics and Mechanism of Liver Injury in 2019 Coronavirus Disease. PMID:32274341
Differential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma. PMID:32273545
Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH. PMID:32271712
High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. PMID:32271093
Translational Control of Secretory Proteins in Health and Disease. PMID:32268488
Systems Biochemistry Approaches to Defining Mitochondrial Protein Function. PMID:32268114
DirectMX - One-Step Reconstitution of Membrane Proteins From Crude Cell Membranes Into Salipro Nanoparticles. PMID:32266242
Erosion of Gene Co-expression Networks Reveal Deregulation of Immune System Processes in Late-Onset Alzheimer's Disease. PMID:32265636
Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines. PMID:32265286
CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110. PMID:32264921
A Key mRNA-miRNA-lncRNA Competing Endogenous RNA Triple Sub-network Linked to Diagnosis and Prognosis of Hepatocellular Carcinoma. PMID:32257949
Low RAB6C expression is a predictor of tamoxifen benefit in estrogen receptor-positive/progesterone receptor-negative breast cancer. PMID:32257197
CCNB2, NUSAP1 and TK1 are associated with the prognosis and progression of hepatocellular carcinoma, as revealed by co-expression analysis. PMID:32256749
Precision Cardio-Oncology: a Systems-Based Perspective on Cardiotoxicity of Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors. PMID:32253744
Nucleolin-Sle A Glycoforms as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer Cells. PMID:32252346
Pulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features. PMID:32251643
Discovery of a selective inhibitor of doublecortin like kinase 1. PMID:32251410
Urine Extracellular Vesicle GATA2 mRNA Discriminates Biopsy Result in Men with Suspicion of Prostate Cancer. PMID:32250729
Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside. PMID:32247663
Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles. PMID:32245988
Safety and Feasibility of PARP1/2 Imaging with 18F-PARPi in Patients with Head and Neck Cancer. PMID:32245901
Phosphoproteomic characterization of the signaling network resulting from activation of the chemokine receptor CCR2. PMID:32241914
Differential co-expression analysis reveals early stage transcriptomic decoupling in alzheimer's disease. PMID:32241275
Pseudogene-gene functional networks are prognostic of patient survival in breast cancer. PMID:32241256
Cell-type diversity and regionalized gene expression in the planarian intestine. PMID:32240093
Development and validation of a survival model for lung adenocarcinoma based on autophagy-associated genes. PMID:32238163
Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex. PMID:32235678
Multiomics Evaluation of Gastrointestinal and Other Clinical Characteristics of COVID-19. PMID:32234303
Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage. PMID:32229571
Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro. PMID:32228452
IL-4R is expressed on alpha and beta cells of human pancreata. PMID:32224156
Investigating LGALS3BP/90 K glycoprotein in the cerebrospinal fluid of patients with neurological diseases. PMID:32221402
Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer. PMID:32218990
Identification of hub genes associated with outcome of clear cell renal cell carcinoma. PMID:32218839
Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth. PMID:32218467
Heparan sulfate is a clearance receptor for aberrant extracellular proteins. PMID:32211892
Leucine Rich Repeat Kinase 2 and Innate Immunity. PMID:32210756
Cellular processes involved in lung cancer cells exposed to direct current electric field. PMID:32210363
Anatomy of a viral entry platform differentially functionalized by integrins α3 and α6. PMID:32210347
An atlas of human metabolism. PMID:32209698
The signal peptide as a new target for drug design. PMID:32209293
Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease. PMID:32208444
Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer. PMID:32207251
Mass Spectrometry Advances and Perspectives for the Characterization of Emerging Adoptive Cell Therapies. PMID:32204371
Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer. PMID:32201920
Tumor cell-organized fibronectin maintenance of a dormant breast cancer population. PMID:32195352
An array of 60,000 antibodies for proteome-scale antibody generation and target discovery. PMID:32195335
Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma. PMID:32194798
Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. PMID:32193359
5-Aza-2'-deoxycytidine advances the epithelial-mesenchymal transition of breast cancer cells by demethylating Sipa1 promoter-proximal elements. PMID:32193333
Brain manganese and the balance between essential roles and neurotoxicity. PMID:32188696
Discovery of non-HLA antibodies associated with cardiac allograft rejection and development and validation of a non-HLA antigen multiplex panel: From bench to bedside. PMID:32185871
Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress. PMID:32183456
An Overview on ERAP Roles in Infectious Diseases. PMID:32183384
Ependymoma Pediatric Brain Tumor Protein Fingerprinting by Integrated Mass Spectrometry Platforms: A Pilot Investigation. PMID:32183175
Genomic Landscape and Mutational Spectrum of ADAMTS Family Genes in Mendelian Disorders Based on Gene Evidence Review for Variant Interpretation. PMID:32183147
Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae. PMID:32182256
Catestatin improves insulin sensitivity by attenuating endoplasmic reticulum stress: In vivo and in silico validation. PMID:32180905
The transcription factor CUX1 negatively regulates invasion in castrate resistant prostate cancer. PMID:32180898
Combination of PD-1 Inhibitor and OX40 Agonist Induces Tumor Rejection and Immune Memory in Mouse Models of Pancreatic Cancer. PMID:32179091
End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression. PMID:32179051
A FITM1-Related Methylation Signature Predicts the Prognosis of Patients With Non-Viral Hepatocellular Carcinoma. PMID:32174969
PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers. PMID:32172476
Machine learning prediction of oncology drug targets based on protein and network properties. PMID:32171238
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake. PMID:32170013
Membrane mucins of the intestine at a glance. PMID:32169835
APEX1 is a novel diagnostic and prognostic biomarker for hepatocellular carcinoma. PMID:32167932
A miRNA- and mRNA-seq-Based Feature Selection Approach for Kidney Cancer Biomakers. PMID:32165847
A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation. PMID:32163402
Toward Development of the Male Pill: A Decade of Potential Non-hormonal Contraceptive Targets. PMID:32161754
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy. PMID:32161261
CD29 identifies IFN-γ-producing human CD8+ T cells with an increased cytotoxic potential. PMID:32161126
Fibroblast-specific genome-scale modelling predicts an imbalance in amino acid metabolism in Refsum disease. PMID:32160399
Genomics and Prognosis Analysis of Epithelial-Mesenchymal Transition in Glioma. PMID:32154177
A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs. PMID:32152546
Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs. PMID:32150922
CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation. PMID:32150608
A putative silencer variant in a spontaneous canine model of retinitis pigmentosa. PMID:32150541
Loss of Arhgef11 in the Dahl Salt-Sensitive Rat Protects Against Hypertension-Induced Renal Injury. PMID:32148127
Angiogenin and tRNA fragments in Parkinson's disease and neurodegeneration. PMID:32144338
KCML: a machine-learning framework for inference of multi-scale gene functions from genetic perturbation screens. PMID:32141232
Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases. PMID:32139877
A Caenorhabditis elegans Model for Integrating the Functions of Neuropsychiatric Risk Genes Identifies Components Required for Normal Dendritic Morphology. PMID:32132169
HDMAC: A Web-Based Interactive Program for High-Dimensional Analysis of Molecular Alterations in Cancer. PMID:32127576
Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease. PMID:32127447
The expression landscape of cachexia-inducing factors in human cancers. PMID:32125790
PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression. PMID:32125284
Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes. PMID:32122952
CDX2: A Prognostic Marker in Metastatic Colorectal Cancer Defining a Better BRAF Mutated and a Worse KRAS Mutated Subgroup. PMID:32117703
Identification and validation of key modules and hub genes associated with the pathological stage of oral squamous cell carcinoma by weighted gene co-expression network analysis. PMID:32117620
Germ Cell-Specific Gene 1-Like Protein Regulated by Splicing Factor CUGBP Elav-Like Family Member 5 and Primary Bile Acid Biosynthesis are Prognostic in Glioblastoma Multiforme. PMID:32117422
Tumor-Specific T Cell Activation in Malignant Brain Tumors. PMID:32117316
Expanding Clinical Presentations Due to Variations in THOC2 mRNA Nuclear Export Factor. PMID:32116545
The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. PMID:32116499
Dawn of a New RAMPage. PMID:32115276
FTO Facilitates Lung Adenocarcinoma Cell Progression by Activating Cell Migration Through mRNA Demethylation. PMID:32110044
Endometriotic cell culture contamination and authenticity: a source of bias in in vitro research? PMID:32106286
Insulin-like growth factor-binding proteins play a significant role in the molecular response to imatinib in chronic myeloid leukemia patients. PMID:32104232
Network Pharmacology-Based Investigation of the System-Level Molecular Mechanisms of the Hematopoietic Activity of Samul-Tang, a Traditional Korean Herbal Formula. PMID:32104198
Identification of molecular markers associated with the progression and prognosis of endometrial cancer: a bioinformatic study. PMID:32099532
Peripheral-to-central immune communication at the area postrema glial-barrier following bleomycin-induced sterile lung injury in adult rats. PMID:32097765
Identification of putative biomarkers for Infantile Hemangiomas and Propranolol treatment via data integration. PMID:32094357
Two Novel FAM20C Variants in A Family with Raine Syndrome. PMID:32093234
Cytokine-Induced Guanylate Binding Protein 1 (GBP1) Release from Human Ovarian Cancer Cells. PMID:32093058
Transcriptome analyses reveal molecular mechanisms underlying phenotypic differences among transcriptional subtypes of glioblastoma. PMID:32091665
Development of a high affinity Anticalin® directed against human CD98hc for theranostic applications. PMID:32089738
Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D. PMID:32082316
Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers. PMID:32081859
Conditional Disorder in Small Heat-shock Proteins. PMID:32081587
Squamous differentiation requires G2/mitosis slippage to avoid apoptosis. PMID:32080348
The Relevance of Thimet Oligopeptidase in the Regulation of Energy Metabolism and Diet-Induced Obesity. PMID:32079362
Epigenetic Conservation Is a Beacon of Function: An Analysis Using Methcon5 Software for Studying Gene Methylation. PMID:32078366
REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. PMID:32075961
The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins. PMID:32075873
PPP2R5D-Related Intellectual Disability and Neurodevelopmental Delay: A Review of the Current Understanding of the Genetics and Biochemical Basis of the Disorder. PMID:32074998
Comparison of Prostate-Specific Membrane Antigen Expression Levels in Human Salivary Glands to Non-Human Primates and Rodents. PMID:32074455
Validating indicators of CNS disorders in a swine model of neurological disease. PMID:32074109
Neurotoxicity including posterior reversible encephalopathy syndrome after initiation of calcineurin inhibitors in transplanted methylmalonic acidemia patients: Two case reports and review of the literature. PMID:32071844
Integrated analysis of the roles and prognostic value of RNA binding proteins in lung adenocarcinoma. PMID:32071816
A census of pathway maps in cancer systems biology. PMID:32066900
The kinase polypharmacology landscape of clinical PARP inhibitors. PMID:32066817
Large epigenome-wide association study of childhood ADHD identifies peripheral DNA methylation associated with disease and polygenic risk burden. PMID:32066674
HMI-PRED: A Web Server for Structural Prediction of Host-Microbe Interactions Based on Interface Mimicry. PMID:32061934
Analysis of Ras-effector interaction competition in large intestine and colorectal cancer context. PMID:32057289
Restoration of MARCKS enhances chemosensitivity in cancer. PMID:32056006
VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury. PMID:32055648
EGFR modulates complement activation in head and neck squamous cell carcinoma. PMID:32054454
Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions. PMID:32054438
The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β. PMID:32053590
Mechanical regulation of glycolysis via cytoskeleton architecture. PMID:32051585
Using the Gibbs Function as a Measure of Human Brain Development Trends from Fetal Stage to Advanced Age. PMID:32046179
Relationship between NAMPT/PBEF/visfatin and prognosis of patients with malignant tumors: a systematic review and meta-analysis. PMID:32042801
A mutation map for human glycoside hydrolase genes. PMID:32039448
HSD17B13 truncated variant is associated with a mild hepatic phenotype in Wilson's Disease. PMID:32039348
Targeting GPCRs Against Cardiotoxicity Induced by Anticancer Treatments. PMID:32039239
Classification of Trispanins: A Diverse Group of Proteins That Function in Membrane Synthesis and Transport Mechanisms. PMID:32039202
The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer. PMID:32038501
Proteomic profiling and identification of significant markers from high-grade osteosarcoma after cryotherapy and irradiation. PMID:32034162
EV-101: A Phase I Study of Single-Agent Enfortumab Vedotin in Patients With Nectin-4-Positive Solid Tumors, Including Metastatic Urothelial Carcinoma. PMID:32031899
The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling. PMID:32029705
Systematic functional identification of cancer multi-drug resistance genes. PMID:32028983
Protein disulfide isomerases are promising targets for predicting the survival and tumor progression in glioma patients. PMID:32023222
Exploring Metabolic Consequences of CPS1 and CAD Dysregulation in Hepatocellular Carcinoma by Network Reconstruction. PMID:32021853
A Unique Regulation Region in the 3' UTR of HLA-G with a Promising Potential. PMID:32019184
The Water Channel Aquaporin 8 is a Critical Regulator of Intestinal Fluid Homeostasis in Collagenous Colitis. PMID:32016376
An optimized chemical-genetic method for cell-specific metabolic labeling of RNA. PMID:32015544
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine. PMID:32015474
Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy. PMID:32012846
IGF2BP3 From Physiology to Cancer: Novel Discoveries, Unsolved Issues, and Future Perspectives. PMID:32010687
Identification of differentially expressed protein-coding genes in lung adenocarcinomas. PMID:32010276
Dysregulated lncRNA-miRNA-mRNA Network Reveals Patient Survival-Associated Modules and RNA Binding Proteins in Invasive Breast Carcinoma. PMID:32010179
Complex impact of DNA methylation on transcriptional dysregulation across 22 human cancer types. PMID:32002550
Effect of small molecule signaling in PepFect14 transfection. PMID:31999754
GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents. PMID:31999650
The omics revolution: beyond genomics. A meeting report. PMID:31997976
Senescence-associated genes and non-coding RNAs function in pancreatic cancer progression. PMID:31997706
Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans. PMID:31996024
Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency. PMID:31995689
RNA editing as a therapeutic approach for retinal gene therapy requiring long coding sequences. PMID:31991730
Functional and transcriptomic characterization of cisplatin-resistant AGS and MKN-28 gastric cancer cell lines. PMID:31990955
Exploring genetic targets of psoriasis using genome wide association studies (GWAS) for drug repurposing. PMID:31988837
Fibroblast growth factor signaling in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: Paving the way to hepatocellular carcinoma. PMID:31988589
Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer. PMID:31988584
Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans. PMID:31987839
Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia. PMID:31985809
Single nucleotide polymorphisms in the dual specificity phosphatase genes and risk of necrotizing enterocolitis in premature infant. PMID:31985475
DNMT1 mutations leading to neurodegeneration paradoxically reflect on mitochondrial metabolism. PMID:31984424
Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation. PMID:31982949
Convergent systems-based approaches identify a role for OCIAD1 in Alzheimer's disease. PMID:31981980
A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population. PMID:31975031
ISOGO: Functional annotation of protein-coding splice variants. PMID:31974522
The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival. PMID:31968056
Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors. PMID:31967407
Aggregation of Omic Data and Secretome Prediction Enable the Discovery of Candidate Plasma Biomarkers for Beef Tenderness. PMID:31963926
Association of α/β-Hydrolase D16B with Bovine Conception Rate and Sperm Plasma Membrane Lipid Composition. PMID:31963602
The Genomes of the Livebearing Fish Species Poeciliopsis retropinna and Poeciliopsis turrubarensis Reflect Their Different Reproductive Strategies. PMID:31960923
Weighted gene co-expression network analysis identifies CCNA2 as a treatment target of prostate cancer through inhibiting cell cycle. PMID:31956366
Monogenic causes of non-obstructive azoospermia: challenges, established knowledge, limitations and perspectives. PMID:31955275
Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation. PMID:31953380
A comparison of gene expression and DNA methylation patterns across tissues and species. PMID:31953346
Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis. PMID:31953345
The ELIXIR Core Data Resources: fundamental infrastructure for the life sciences. PMID:31950984
miR-TV: an interactive microRNA Target Viewer for microRNA and target gene expression interrogation for human cancer studies. PMID:31950188
Beyond mass spectrometry, the next step in proteomics. PMID:31950079
The Role of Transient Receptor Potential Melastatin 7 (TRPM7) in Cell Viability: A Potential Target to Suppress Breast Cancer Cell Cycle. PMID:31947967
Direct Activation of TRPC3 Channels by the Antimalarial Agent Artemisinin. PMID:31947602
Control of Astrocyte Quiescence and Activation in a Synthetic Brain Hydrogel. PMID:31943839
Combined Expression of Plasma Thrombospondin-2 and CA19-9 for Diagnosis of Pancreatic Cancer and Distal Cholangiocarcinoma: A Proteome Approach. PMID:31943574
Polycystin 2 is increased in disease to protect against stress-induced cell death. PMID:31941974
De novo variants in exomes of congenital heart disease patients identify risk genes and pathways. PMID:31941532
Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor. PMID:31940495
Seminal fluid-mediated fitness effects in the simultaneously hermaphroditic flatworm Macrostomum lignano. PMID:31938489
Effect of miR-483-5p on apoptosis of lung cancer cells through targeting of RBM5. PMID:31938444
Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension. PMID:31937874
SeXY chromosomes and the immune system: reflections after a comparative study. PMID:31937374
SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation. PMID:31935717
Differential roles of factors IX and XI in murine placenta and hemostasis under conditions of low tissue factor. PMID:31935292
Integrated assessment of CDK1 upregulation in thyroid cancer. PMID:31934275
The clinicopathological significance of decreased miR-125b-5p in hepatocellular carcinoma: evidence based on RT-qPCR, microRNA-microarray, and microRNA-sequencing. PMID:31933718
Condensation of delta-1-piperideine-6-carboxylate with ortho-aminobenzaldehyde allows its simple, fast, and inexpensive quantification in the urine of patients with antiquitin deficiency. PMID:31930735
A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis. PMID:31928310
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression. PMID:31926610
Integration of IgA and IgG Autoantigens Improves Performance of Biomarker Panels for Early Diagnosis of Lung Cancer. PMID:31924693
Inflammasome expression is higher in ovarian tumors than in normal ovary. PMID:31923221
More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis. PMID:31921102
Live-Cell Assays for Cell Stress Responses Reveal New Patterns of Cell Signaling Caused by Mutations in Rhodopsin, α-Synuclein and TDP-43. PMID:31920544
GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. PMID:31919661
Mechanisms of tissue and cell-type specificity in heritable traits and diseases. PMID:31913361
Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association. PMID:31911620
Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains. PMID:31911579
Differential Expression in Testis and Liver Transcriptomes from Four Species of Peromyscus (Rodentia: Cricetidae). PMID:31909812
DDX3X Multifunctionally Modulates Tumor Progression and Serves as a Prognostic Indicator to Predict Cancer Outcomes. PMID:31906196
A Class II-Restricted CD8γ13 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection. PMID:31899500
TRPV6 as A Target for Cancer Therapy. PMID:31897233
Serum coiled-coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma. PMID:31897206
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion. PMID:31896772
A re-evaluation of LINE-1 ORF2 expression in LNCaP prostate cancer cells. PMID:31890047
High-level integration of murine intestinal transcriptomics data highlights the importance of the complement system in mucosal homeostasis. PMID:31888466
Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin. PMID:31888244
Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System. PMID:31888217
Genetic variation drives seasonal onset of hibernation in the 13-lined ground squirrel. PMID:31886416
Longitudinal serum biomarker screening identifies malate dehydrogenase 2 as candidate prognostic biomarker for Duchenne muscular dystrophy. PMID:31881125
ABC Transporters at the Blood-Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas. PMID:31878061
Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer. PMID:31875161
Substrates, inhibitors, and probes of mammalian transglutaminase 2. PMID:31874171
Quantitative microscopy reveals dynamics and fate of clustered IRE1α. PMID:31871156
Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer. PMID:31871120
The STK16 inhibitor STK16-IN-1 inhibits non-adrenergic and non-neurogenic smooth muscle contractions in the human prostate and the human male detrusor. PMID:31867686
Characterization of Human Dosage-Sensitive Transcription Factor Genes. PMID:31867040
The Thyroid Hormone Receptor-RUNX2 Axis: A Novel Tumor Suppressive Pathway in Breast Cancer. PMID:31865591
Profiling of the plasma proteome across different stages of human heart failure. PMID:31862877
IL35 modulation altered survival, cytokine environment and histopathological consequences during malaria infection in mice. PMID:31856836
Upregulation of β3-adrenoceptors-a general marker of and protective mechanism against hypoxia? PMID:31853614
Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer. PMID:31852841
Transcriptome-Guided Drug Repositioning. PMID:31842375
Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children. PMID:31841498
PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis. PMID:31841108
Single-cell connectomic analysis of adult mammalian lungs. PMID:31840053
High-resolution chromosomal microarray analysis for copy-number variations in high-functioning autism reveals large aberration typical for intellectual disability. PMID:31838600
Pathogenic copy number variants are detected in a subset of patients with gastrointestinal malformations. PMID:31837127
LAMTOR5 raises abnormal initiation of O-glycosylation in breast cancer metastasis via modulating GALNT1 activity. PMID:31836847
Prostate-Derived ETS Factor (PDEF) Modulates Yes Associated Protein 1 (YAP1) in Prostate Cancer Cells: A Potential Cross-Talk between PDEF and Hippo Signaling. PMID:31835563
Loss of RAR-related orphan receptor alpha (RORα) selectively lowers docosahexaenoic acid in developing cerebellum. PMID:31835092
Proteomics: a powerful tool to study plant responses to biotic stress. PMID:31832077
Mapping human N-linked glycoproteins and glycosylation sites using mass spectrometry. PMID:31831916
Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers. PMID:31831737
Identification of microRNAs in skeletal muscle associated with lung cancer cachexia. PMID:31828982
Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry. PMID:31826992
Comprehensive Identification and Characterization of Human Secretome Based on Integrative Proteomic and Transcriptomic Data. PMID:31824949
Development of Immature CD4+CD8+T Cells Into Mature CD4+ T Cells Requires Alpha-1 Antitrypsin as Observed by Treatment in HIV-1 Infected and Uninfected Controls. PMID:31824943
Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer. PMID:31819186
The Fusion of Lipid and DNA Nanotechnology. PMID:31816934
Type I fatty acid synthase trapped in the octanoyl-bound state. PMID:31811668
In Vitro Expansion of Keratinocytes on Human Dermal Fibroblast-Derived Matrix Retains Their Stem-Like Characteristics. PMID:31811191
Ovarian cancer stem cells and targeted therapy. PMID:31810474
Proteogenomics of Colorectal Cancer Liver Metastases: Complementing Precision Oncology with Phenotypic Data. PMID:31805664
Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD. PMID:31805375
Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides. PMID:31802121
Structural basis for the dimerization of Gemin5 and its role in protein recruitment and translation control. PMID:31799608
Casein Kinase 1 Delta Regulates Cell Proliferation, Response to Chemotherapy and Migration in Human Ovarian Cancer Cells. PMID:31799185
Mass Cytometry Imaging for the Study of Human Diseases-Applications and Data Analysis Strategies. PMID:31798587
Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. PMID:31796108
Comparison of tumour and serum specific microRNA changes dissecting their role in pancreatic ductal adenocarcinoma: a meta-analysis. PMID:31795960
The Molecular Genetics of Gordon Syndrome. PMID:31795491
Integrative In Silico and In Vitro Transcriptomics Analysis Revealed Gene Expression Changes and Oncogenic Features of Normal Cholangiocytes after Chronic Alcohol Exposure. PMID:31795085
ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy. PMID:31794718
LASP1 promotes proliferation, metastasis, invasion in head and neck squamous cell carcinoma and through direct interaction with HSPA1A. PMID:31793711
JAK1 as a prognostic marker and its correlation with immune infiltrates in breast cancer. PMID:31790361
Sex-Based Analysis of De Novo Variants in Neurodevelopmental Disorders. PMID:31785789
The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data. PMID:31784565
Programmed DNA elimination of germline development genes in songbirds. PMID:31784533
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function. PMID:31784108
Analysis of the Human Protein Atlas Image Classification competition. PMID:31780840
Rapid affinity purification of intracellular organelles using a twin strep tag. PMID:31780580
Characterizing renal involvement in Hermansky-Pudlak Syndrome in a zebrafish model. PMID:31776394
Chemoenzymatic Semisynthesis of Proteins. PMID:31774265
An omics perspective on drug target discovery platforms. PMID:31774113
Update on KMT2B-Related Dystonia. PMID:31768667
Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease. PMID:31768427
Coauthor Country Affiliations in International Collaborative Research Funded by the US National Institutes of Health, 2009 to 2017. PMID:31755947
CACYBP Enhances Cytoplasmic Retention of P27Kip1 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation. PMID:31754404
Identifying gene function and module connections by the integration of multispecies expression compendia. PMID:31754022
Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location. PMID:31753726
In Situ Analysis Reveals That CFTR Is Expressed in Only a Small Minority of β-Cells in Normal Adult Human Pancreas. PMID:31748811
The Human Immunopeptidome Project: A Roadmap to Predict and Treat Immune Diseases. PMID:31744855
Phenotypic analysis combined with tandem mass tags (TMT) labeling reveal the heterogeneity of strawberry stolon buds. PMID:31744478
The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma. PMID:31739284
Is MYND Domain-Mediated Assembly of SMYD3 Complexes Involved in Calcium Dependent Signaling? PMID:31737645
Comprehensive investigation of key biomarkers and pathways in hepatitis B virus-related hepatocellular carcinoma. PMID:31737106
Expression of CCCTC-binding factor (CTCF) is linked to poor prognosis in prostate cancer. PMID:31736271
Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines. PMID:31733513
Structural basis of the strong cell-cell junction formed by cadherin-23. PMID:31729176
PCOSBase: a manually curated database of polycystic ovarian syndrome. PMID:31725861
The neXtProt knowledgebase in 2020: data, tools and usability improvements. PMID:31724716
Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production. PMID:31721422
Wnt-11 Expression Promotes Invasiveness and Correlates with Survival in Human Pancreatic Ductal Adeno Carcinoma. PMID:31718047
In Silico Study of Rett Syndrome Treatment-Related Genes, MECP2, CDKL5, and FOXG1, by Evolutionary Classification and Disordered Region Assessment. PMID:31717404
Proteomic analysis of eleven tissues in the Chinese giant salamander (Andrias davidianus). PMID:31712686
Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently. PMID:31712655
Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double-Stranded DNA Donors. PMID:31710422
Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis. PMID:31709908
Selective Histone Deacetylase 6 Inhibition Normalizes B Cell Activation and Germinal Center Formation in a Model of Systemic Lupus Erythematosus. PMID:31708928
Gene expression analysis of the cerebellar cortex in essential tremor. PMID:31707044
Megalin: A bridge connecting kidney, the renin-angiotensin system, and atherosclerosis. PMID:31707037
Identifying inaccuracies in gene expression estimates from unstranded RNA-seq data. PMID:31704962
ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress. PMID:31699981
Identification of key candidate genes and molecular pathways in white fat browning: an anti-obesity drug discovery based on computational biology. PMID:31699147
TCR Fingerprinting and Off-Target Peptide Identification. PMID:31695703
Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism. PMID:31693977
3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake. PMID:31692167
Aging results in accumulation of M1 and M2 hepatic macrophages and a differential response to gadolinium chloride. PMID:31691025
Co-regulation map of the human proteome enables identification of protein functions. PMID:31690884
PRADC1: a novel metabolic-responsive secretory protein that modulates physical activity and adiposity. PMID:31689374
CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth. PMID:31685994
ProTstab - predictor for cellular protein stability. PMID:31684883
MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis. PMID:31684860
Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications. PMID:31682939
GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies. PMID:31681577
2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels. PMID:31680972
An expanded mouse testis transcriptome and mass spectrometry defines novel proteins. PMID:31677600
Defining Transcriptional Signatures of Human Hair Follicle Cell States. PMID:31676413
Klf14 is an imprinted transcription factor that regulates placental growth. PMID:31675530
Preprotein signature for full susceptibility to the co-translational translocation inhibitor cyclotriazadisulfonamide. PMID:31675144
Covalently modified carboxyl side chains on cell surface leads to a novel method toward topology analysis of transmembrane proteins. PMID:31673029
Peptides of tetraspanin oncoprotein CD151 trigger active immunity against primary tumour and experimental lung metastasis. PMID:31668880
Focus on FKBP51: A molecular link between stress and metabolic disorders. PMID:31668388
The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly. PMID:31666358
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. PMID:31665640
Unraveling Triple-Negative Breast Cancer Tumor Microenvironment Heterogeneity: Towards an Optimized Treatment Approach. PMID:31665482
The Selective Progesterone Receptor Modulator Ulipristal Acetate Inhibits the Activity of the Glucocorticoid Receptor. PMID:31665442
Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells? PMID:31662755
Brain Region-Specific nAChR and Associated Protein Abundance Alterations Following Chronic Nicotine and/or Menthol Exposure. PMID:31657575
Combinatorial prediction of marker panels from single-cell transcriptomic data. PMID:31657111
PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance. PMID:31655611
MIC_Locator: a novel image-based protein subcellular location multi-label prediction model based on multi-scale monogenic signal representation and intensity encoding strategy. PMID:31655541
ACAT1 and Metabolism-Related Pathways Are Essential for the Progression of Clear Cell Renal Cell Carcinoma (ccRCC), as Determined by Co-expression Network Analysis. PMID:31649873
Oncomodulin: The Enigmatic Parvalbumin Protein. PMID:31649505
Increased CMTM6 can predict the clinical response to PD-1 inhibitors in non-small cell lung cancer patients. PMID:31646074
Gene4Denovo: an integrated database and analytic platform for de novo mutations in humans. PMID:31642496
Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers. PMID:31637211
Proteomics and Metabolomics in Kidney Disease, including Insights into Etiology, Treatment, and Prevention. PMID:31636087
Awakening dormant glycosyltransferases in CHO cells with CRISPRa. PMID:31631317
Selective loss of phosphoserine aminotransferase 1 (PSAT1) suppresses migration, invasion, and experimental metastasis in triple negative breast cancer. PMID:31630284
Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress. PMID:31625393
Sarcomeric myopathies associated with tremor: new insights and perspectives. PMID:31620961
Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease. PMID:31619995
Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines. PMID:31616026
Biological Network Approaches and Applications in Rare Disease Studies. PMID:31614842
Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72. PMID:31612854
Identification of a Nine-Gene Signature and Establishment of a Prognostic Nomogram Predicting Overall Survival of Pancreatic Cancer. PMID:31612115
Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells. PMID:31611601
Candidate Genes and MiRNAs Linked to the Inverse Relationship Between Cancer and Alzheimer's Disease: Insights From Data Mining and Enrichment Analysis. PMID:31608105
Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2. PMID:31605148
Genome-Scale Metabolic Modeling from Yeast to Human Cell Models of Complex Diseases: Latest Advances and Challenges. PMID:31602620
Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis. PMID:31602402
Diagnostic and prognostic biomarkers of Human Leukocyte Antigen complex for hepatitis B virus-related hepatocellular carcinoma. PMID:31602270
Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. PMID:31600961
Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. PMID:31599721
Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 3.0. PMID:31599596
snoDB: an interactive database of human snoRNA sequences, abundance and interactions. PMID:31598696
Uterine deficiency of high-mobility group box-1 (HMGB1) protein causes implantation defects and adverse pregnancy outcomes. PMID:31595043
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. PMID:31594949
Absolute Quantification of Apolipoproteins Following Treatment with Omega-3 Carboxylic Acids and Fenofibrate Using a High Precision Stable Isotope-labeled Recombinant Protein Fragments Based SRM Assay. PMID:31591263
Bringing Open Data to Whole Slide Imaging. PMID:31579322
Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel. PMID:31578243
High-Content Imaging for Large-Scale Detection of Low-Affinity Extracellular Protein Interactions. PMID:31578119
Highly heritable and functionally relevant breed differences in dog behaviour. PMID:31575369
Pyk2-dependent phosphorylation of LSR enhances localization of LSR and tricellulin at tricellular tight junctions. PMID:31574128
Pilot-Scale Study Of Human Plasma Proteomics Identifies ApoE And IL33 As Markers In Atopic Asthma. PMID:31571934
Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922. PMID:31569342
Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling. PMID:31568691
Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines. PMID:31565104
Portrait of Tissue-Specific Coexpression Networks of Noncoding RNAs (miRNA and lncRNA) and mRNAs in Normal Tissues. PMID:31565069
PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. PMID:31564549
Tissue-specific mouse mRNA isoform networks. PMID:31562339
Loss of myosin Vb promotes apical bulk endocytosis in neonatal enterocytes. PMID:31562230
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis. PMID:31558756
The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo. PMID:31555430
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling. PMID:31554934
Single-cell transcriptomic profiling of the aging mouse brain. PMID:31551601
Distinct Roles for BET Family Members in Estrogen Receptor α Enhancer Function and Gene Regulation in Breast Cancer Cells. PMID:31551256
SoyCSN: Soybean context-specific network analysis and prediction based on tissue-specific transcriptome data. PMID:31549018
d-amino Acids in Health and Disease: A Focus on Cancer. PMID:31547425
Diagnostic and prognostic values of C‑X‑C motif chemokine ligand 3 in patients with colon cancer. PMID:31545503
Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer. PMID:31545451
FOXN3 hyperglycemic risk allele and insulin sensitivity in humans. PMID:31543974
Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5. PMID:31539416
Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism. PMID:31537871
Characterisation and localisation of the endocannabinoid system components in the adult human testis. PMID:31537814
Dimethylguanidino Valerate: A Lifestyle-Related Metabolite Associated With Future Coronary Artery Disease and Cardiovascular Mortality. PMID:31533499
A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics. PMID:31533246
Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice. PMID:31526103
ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction. PMID:31525885
Dosage regulation, and variation in gene expression and copy number of human Y chromosome ampliconic genes. PMID:31525193
Unsupervised machine learning using an imaging mass spectrometry dataset automatically reassembles grey and white matter. PMID:31519997
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma. PMID:31519915
Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks. PMID:31515267
Control of human testis-specific gene expression. PMID:31514204
The association of integration patterns of human papilloma virus and single nucleotide polymorphisms on immune- or DNA repair-related genes in cervical cancer patients. PMID:31511581
Unexpected roles for ADH1 and SORD in catalyzing the final step of erythritol biosynthesis. PMID:31511322
A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic Approach. PMID:31511258
Hyperglycemia induces spermatogenic disruption via major pathways of diabetes pathogenesis. PMID:31506549
Aberrant Regulation of RAD51 Promotes Resistance of Neoadjuvant Endocrine Therapy in ER-positive Breast Cancer. PMID:31506496
Genome reading by the NF-κB transcription factors. PMID:31501881
HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. PMID:31500569
Analysis of CDKN1C in fetal growth restriction and pregnancy loss. PMID:31497289
Multi-view Subspace Clustering Analysis for Aggregating Multiple Heterogeneous Omics Data. PMID:31497031
High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification. PMID:31495056
A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. PMID:31494632
Neuromedin U: A Small Peptide in the Big World of Cancer. PMID:31492042
Copy number variants in lipid metabolism genes are associated with gallstones disease in men. PMID:31485028
The Coxsackievirus and Adenovirus Receptor, a Required Host Factor for Recovirus Infection, Is a Putative Enteric Calicivirus Receptor. PMID:31484750
Relative stabilities of wild-type and mutant glial fibrillary acidic protein in patients with Alexander disease. PMID:31484723
Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome. PMID:31481669
Syndecan-Mediated Ligation of ECM Proteins Triggers Proliferative Arrest of Disseminated Tumor Cells. PMID:31481497
The Known and Potential Intersections of Rab-GTPases in Human Papillomavirus Infections. PMID:31475144
Dynamical Electrical Complexity Is Reduced during Neuronal Differentiation in Autism Spectrum Disorder. PMID:31474529
Minor intron splicing revisited: identification of new minor intron-containing genes and tissue-dependent retention and alternative splicing of minor introns. PMID:31470809
Mesencephalic Astrocyte-Derived Neurotrophic Factor Inhibits Liver Cancer Through Small Ubiquitin-Related Modifier (SUMO)ylation-Related Suppression of NF-κB/Snail Signaling Pathway and Epithelial-Mesenchymal Transition. PMID:31469428
DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases. PMID:31467668
Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer. PMID:31467540
Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-β fibrils. PMID:31467325
Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2. PMID:31466081
Stoichioproteomics reveal oxygen usage bias, key proteins and pathways in glioma. PMID:31464612
The effects of di-butyl phthalate exposure from medications on human sperm RNA among men. PMID:31455814
Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy. PMID:31452838
Screening of potential biomarkers in hepatitis C virus-induced hepatocellular carcinoma using bioinformatic analysis. PMID:31452738
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program. PMID:31451708
Divide and conquer: two stem cell populations in squamous epithelia, reserves and the active duty forces. PMID:31451683
Targeting Immunophenotypic Markers on Leukemic Stem Cells: How Lessons from Current Approaches and Advances in the Leukemia Stem Cell (LSC) Model Can Inform Better Strategies for Treating Acute Myeloid Leukemia (AML). PMID:31451539
Mechanism and Regulation of Gasdermin-Mediated Cell Death. PMID:31451512
Construction and Investigation of a lncRNA-Associated ceRNA Regulatory Network in Cholangiocarcinoma. PMID:31448221
Target Genes of Autism Risk Loci in Brain Frontal Cortex. PMID:31447881
Expression Levels of 4 Genes in Colon Tissue Might Be Used to Predict Which Patients Will Enter Endoscopic Remission After Vedolizumab Therapy for Inflammatory Bowel Diseases. PMID:31446181
A phase I study of enfortumab vedotin in Japanese patients with locally advanced or metastatic urothelial carcinoma. PMID:31444589
Differential gene expression and gene-set enrichment analysis in Caco-2 monolayers during a 30-day timeline with Dexamethasone exposure. PMID:31438773
Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination. PMID:31437751
Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice Phenotype Characterization. PMID:31431000
Progress on Identifying and Characterizing the Human Proteome: 2019 Metrics from the HUPO Human Proteome Project. PMID:31430157
Localization-specific distributions of protein pI in human proteome are governed by local pH and membrane charge. PMID:31429701
Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues. PMID:31427819
Rho GTPases in cancer: friend or foe? PMID:31427738
KCNMA1-linked channelopathy. PMID:31427379
Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion. PMID:31427285
Cdh4 Down-Regulation Impairs in Vivo Infiltration and Malignancy in Patients Derived Glioblastoma Cells. PMID:31426573
Deciphering GRINA/Lifeguard1: Nuclear Location, Ca2+ Homeostasis and Vesicle Transport. PMID:31426446
Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism. PMID:31422917
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. PMID:31422913
Loss of microfibril-associated protein 5 (MFAP5) expression in colon cancer stroma. PMID:31422503
Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling. PMID:31421261
Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic Modeling. PMID:31417867
A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. PMID:31417100
The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation. PMID:31409643
The analysis of risk factors for diabetic nephropathy progression and the construction of a prognostic database for chronic kidney diseases. PMID:31409386
Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses. PMID:31408441
Furin-mediated protein processing in infectious diseases and cancer. PMID:31406574
MicroRNA let-7-TGFBR3 signalling regulates cardiomyocyte apoptosis after infarction. PMID:31401194
A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination. PMID:31399485
Targeting CDK9 for treatment of colorectal cancer. PMID:31398271
Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs. PMID:31396219
DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease. PMID:31387232
Adaptation to Extreme Environments in an Admixed Human Population from the Atacama Desert. PMID:31384924
Stoichiogenomics reveal oxygen usage bias, key proteins and pathways associated with stomach cancer. PMID:31383879
The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells. PMID:31381610
Computational Analysis of HLA-presentation of Non-synonymous Recipient Mismatches Indicates Effect on the Risk of Chronic Graft-vs.-Host Disease After Allogeneic HSCT. PMID:31379830
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5. PMID:31379819
Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells. PMID:31379806
Molecular Systems Biology of Neurodevelopmental Disorders, Rett Syndrome as an Archetype. PMID:31379529
Mapping Interactions of Microbial Metabolites with Human G-Protein-Coupled Receptors. PMID:31378678
A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology. PMID:31378672
Exploring the molecular basis of neuronal excitability in a vocal learner. PMID:31375088
Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A. PMID:31374199
The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour. PMID:31371726
Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma. PMID:31369399
Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions. PMID:31367837
Relating evolutionary selection and mutant clonal dynamics in normal epithelia. PMID:31362624
Comprehensive analysis of differentially expressed circRNAs revealed a ceRNA network in pancreatic ductaladenocarcinoma. PMID:31360192
T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance. PMID:31355495
Promoter conservation in HDACs points to functional implications. PMID:31351464
The genome of the live-bearing fish Heterandria formosa implicates a role of conserved vertebrate genes in the evolution of placental fish. PMID:31349784
Decreased expression of SLC16A12 mRNA predicts poor prognosis of patients with clear cell renal cell carcinoma. PMID:31348313
Exosome release and cargo in Down syndrome. PMID:31347291
Intrinsic expression of viperin regulates thermogenesis in adipose tissues. PMID:31341090
The diagnostic and prognostic role of RhoA in hepatocellular carcinoma. PMID:31339860
Chemotactic Ligands that Activate G-Protein-Coupled Formylpeptide Receptors. PMID:31336833
Upregulation of nucleoprotein AHNAK is associated with poor outcome of pancreatic ductal adenocarcinoma prognosis via mediating epithelial-mesenchymal transition. PMID:31333803
Gene Therapy Corrects Brain and Behavioral Pathologies in CLN6-Batten Disease. PMID:31331814
AKAP6 and phospholamban colocalize and interact in HEK-293T cells and primary murine cardiomyocytes. PMID:31325238
Estimating dispensable content in the human interactome. PMID:31324802
Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer. PMID:31324208
Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis. PMID:31324198
Assessing key decisions for transcriptomic data integration in biochemical networks. PMID:31323017
Transcriptional control and transcriptomic analysis of lipid metabolism in skin barrier formation and atopic dermatitis (AD). PMID:31322970
Identification of a missense variant in CLDN2 in obstructive azoospermia. PMID:31320686
Computational Drug Screening Identifies Compounds Targeting Renal Age-associated Molecular Profiles. PMID:31316728
The Warburg Effect Is Associated With Tumor Aggressiveness in Testicular Germ Cell Tumors. PMID:31316469
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. PMID:31316208
Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis. PMID:31316008
Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production. PMID:31311960
Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells. PMID:31311882
Identification of novel genes associated with a poor prognosis in pancreatic ductal adenocarcinoma via a bioinformatics analysis. PMID:31311829
Exploring the Molecular Mechanism of the Drug-Treated Breast Cancer Based on Gene Expression Microarray. PMID:31311202
Clinical update on head and neck cancer: molecular biology and ongoing challenges. PMID:31308358
Small-protein Enrichment Assay Enables the Rapid, Unbiased Analysis of Over 100 Low Abundance Factors from Human Plasma. PMID:31308252
Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer. PMID:31307411
Benchmarking subcellular localization and variant tolerance predictors on membrane proteins. PMID:31307390
Identification and analysis of genes associated with head and neck squamous cell carcinoma by integrated bioinformatics methods. PMID:31304688
Cardiac tissue engineering: state-of-the-art methods and outlook. PMID:31297148
Retention of paternal DNA methylome in the developing zebrafish germline. PMID:31296860
A human liver cell atlas reveals heterogeneity and epithelial progenitors. PMID:31292543
Landscape of innate immune system transcriptome and acute T cell-mediated rejection of human kidney allografts. PMID:31292297
Tubulin glutamylation: a skeleton key for neurodegenerative diseases. PMID:31290441
The heterogeneity and complexity of Cannabis extracts as antitumor agents. PMID:31289609
Mapping the protein-protein and genetic interactions of cancer to guide precision medicine. PMID:31288129
Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility. PMID:31285581
Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes. PMID:31282863
Genome-wide functional association networks: background, data & state-of-the-art resources. PMID:31281921
CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. PMID:31281901
Co-expression network analysis identified candidate biomarkers in association with progression and prognosis of breast cancer. PMID:31280346
Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study. PMID:31277479
Large HERCs Function as Tumor Suppressors. PMID:31275856
Milk proteome from in silico data aggregation allows the identification of putative biomarkers of negative energy balance in dairy cows. PMID:31273261
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants. PMID:31273118
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. PMID:31268602
Integrating proteomics and transcriptomics for the identification of potential targets in early colorectal cancer. PMID:31268166
In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes. PMID:31265809
Whole-exome sequencing of ovarian cancer families uncovers putative predisposition genes. PMID:31265121
Genome-wide association analysis uncovers variants for reproductive variation across dog breeds and links to domestication. PMID:31263560
Germline BRCA1 Mutation Detected in a Multiple Endocrine Neoplasia Type 2 Case With RET Codon 634 Mutation. PMID:31263477
Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14. PMID:31261654
Transcriptomes of antigen presenting cells in human thymus. PMID:31261375
Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells. PMID:31260037
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation. PMID:31253574
Quantitative Systems Pharmacology Model of a Masked, Tumor-Activated Antibody. PMID:31250966
Best practices and benchmarks for intact protein analysis for top-down mass spectrometry. PMID:31249407
A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys. PMID:31249312
Multi-omics Biomarker Pipeline Reveals Elevated Levels of Protein-glutamine Gamma-glutamyltransferase 4 in Seminal Plasma of Prostate Cancer Patients. PMID:31249104
Estimation of allele-specific fitness effects across human protein-coding sequences and implications for disease. PMID:31249063
Leveraging the Role of the Metastatic Associated Protein Anterior Gradient Homologue 2 in Unfolded Protein Degradation: A Novel Therapeutic Biomarker for Cancer. PMID:31247903
Biological Pathway Specificity in the Cell-Does Molecular Diversity Matter? PMID:31245864
A Circulating Tumor Cell-RNA Assay for Assessment of Androgen Receptor Signaling Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer. PMID:31244925
Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'. PMID:31244471
Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics. PMID:31243108
Parent-of-origin-specific allelic expression in the human placenta is limited to established imprinted loci and it is stably maintained across pregnancy. PMID:31242935
Proteolytic Rafts for Improving Intraparenchymal Migration of Minimally Invasively Administered Hydrogel-Embedded Stem Cells. PMID:31238564
The roles of the human SETMAR (Metnase) protein in illegitimate DNA recombination and non-homologous end joining repair. PMID:31238295
Unified single-cell analysis of testis gene regulation and pathology in five mouse strains. PMID:31237565
Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer. PMID:31233188
Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults. PMID:31231205
Characterization of Contractile Proteins from Skeletal Muscle Using Gel-Based Top-Down Proteomics. PMID:31226838
The role of hydrophobic matching on transmembrane helix packing in cells. PMID:31225439
CNBP controls transcription by unfolding DNA G-quadruplex structures. PMID:31219592
Gene Information eXtension (GIX): effortless retrieval of gene product information on any website. PMID:31217594
Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease. PMID:31217356
HNF4α and CDX2 Regulate Intestinal YAP1 Promoter Activity. PMID:31216773
Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective. PMID:31216675
Consequences of Y chromosome microdeletions beyond male infertility. PMID:31214882
The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease. PMID:31214167
Signatures of Recent Positive Selection in Enhancers Across 41 Human Tissues. PMID:31213516
Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium. PMID:31209240
Genetic Mutations Underlying Phenotypic Plasticity in Basosquamous Carcinoma. PMID:31207229
Development of a predictive model for stromal content in prostate cancer samples to improve signature performance. PMID:31206668
The p52 isoform of SHC1 is a key driver of breast cancer initiation. PMID:31202267
Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia. PMID:31200555
Current status and applications of genome-scale metabolic models. PMID:31196170
Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial-mesenchymal transition. PMID:31196164
LncRRIsearch: A Web Server for lncRNA-RNA Interaction Prediction Integrated With Tissue-Specific Expression and Subcellular Localization Data. PMID:31191601
Molecular Mechanisms by Which Selenoprotein K Regulates Immunity and Cancer. PMID:31187393
Indoleamine 2,3-dioxygenase and ischemic heart disease: a Mendelian Randomization study. PMID:31186442
Dynamic genome-scale cell-specific metabolic models reveal novel inter-cellular and intra-cellular metabolic communications during ovarian follicle development. PMID:31182013
Spliced X-box Binding Protein 1 Stimulates Adaptive Growth Through Activation of mTOR. PMID:31177839
A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation. PMID:31172184
HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis. PMID:31163988
Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities. PMID:31160710
Bridging the gap between reference and real transcriptomes. PMID:31159855
Small molecule target identification using photo-affinity chromatography. PMID:31155061
Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma. PMID:31154438
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. PMID:31149896
Eleven genes associated with progression and prognosis of endometrial cancer (EC) identified by comprehensive bioinformatics analysis. PMID:31139013
Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C. PMID:31138701
Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies. PMID:31130731
The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination. PMID:31127291
Exploiting Interdata Relationships in Next-generation Proteomics Analysis. PMID:31126983
Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway. PMID:31118659
Angiotensin II-mediated MYH9 downregulation causes structural and functional podocyte injury in diabetic kidney disease. PMID:31118506
Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development. PMID:31116975
ResponseNet v.3: revealing signaling and regulatory pathways connecting your proteins and genes across human tissues. PMID:31114913
Increased expression of TMED2 is an unfavorable prognostic factor in patients with breast cancer. PMID:31114314
RIP2 promotes FcγR-mediated reactive oxygen species production. PMID:31113864
A novel conserved family of Macro-like domains-putative new players in ADP-ribosylation signaling. PMID:31106069
Secretomes from metastatic breast cancer cells, enriched for a prognostically unfavorable LCN2 axis, induce anti-inflammatory MSC actions and a tumor-supportive premetastatic lung. PMID:31105883
Expression profile and functional role of S100A14 in human cancer. PMID:31105881
Gi/o-Protein Coupled Receptors in the Aging Brain. PMID:31105551
Fatty Acid Signaling Mechanisms in Neural Cells: Fatty Acid Receptors. PMID:31105530
Meiotic gene activation in somatic and germ cell tumours. PMID:31102330
Expression of Glypican 3 is an Independent Prognostic Biomarker in Primary Gastro-Esophageal Adenocarcinoma and Corresponding Serum Exosomes. PMID:31100935
Silencing of Aberrant Secretory Protein Expression by Disease-Associated Mutations. PMID:31100385
The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells. PMID:31097295
Profiling Autoantibodies against Salivary Proteins in Sicca Conditions. PMID:31095438
Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling. PMID:31087223
PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. PMID:31086175
c-Met as a new marker of cellular senescence. PMID:31085799
Genome-wide analyses of psychological resilience in U.S. Army soldiers. PMID:31081985
The clinical spectrum of the congenital myasthenic syndrome resulting from COL13A1 mutations. PMID:31081514
Pseudomonas aeruginosa-derived pyocyanin reduces adipocyte differentiation, body weight, and fat mass as mechanisms contributing to septic cachexia. PMID:31078726
Tissue-specific genes as an underutilized resource in drug discovery. PMID:31076736
Cryo-Electron Tomography and Proteomics studies of centrosomes from differentiated quiescent thymocytes. PMID:31076588
Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients. PMID:31070306
Metabolic enzymes expressed by cancer cells impact the immune infiltrate. PMID:31069148
Large-scale in-silico identification of a tumor-specific antigen pool for targeted immunotherapy in triple-negative breast cancer. PMID:31069014
Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells. PMID:31068932
g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). PMID:31066453
Epigenome-wide DNA methylation in placentas from preterm infants: association with maternal socioeconomic status. PMID:31062658
Targeting the High-Mobility Group Box 3 Protein Sensitizes Chemoresistant Ovarian Cancer Cells to Cisplatin. PMID:31061066
FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane. PMID:31056421
The SUMO-Specific Protease Senp2 Regulates SUMOylation, Expression and Function of Human Organic Anion Transporter 3. PMID:31054272
Actin-tropomyosin distribution in non-muscle cells. PMID:31054005
Characterization of CNPY5 and its family members. PMID:31050855
Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function. PMID:31048406
MetAP2 inhibition increases energy expenditure through direct action on brown adipocytes. PMID:31048375
Divergent effects of vitamins K1 and K2 on triple negative breast cancer cells. PMID:31040920
A nanobody-based molecular toolkit provides new mechanistic insight into clathrin-coat initiation. PMID:31038455
Soluble Heparin Binding Epidermal Growth Factor-Like Growth Factor Is a Regulator of GALGT2 Expression and GALGT2-Dependent Muscle and Neuromuscular Phenotypes. PMID:31036568
Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling. PMID:31035605
Network Medicine in the Age of Biomedical Big Data. PMID:31031797
Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals. PMID:31031010
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. PMID:31028174
The Fate of Glutamine in Human Metabolism. The Interplay with Glucose in Proliferating Cells. PMID:31027329
PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel. PMID:31023925
Strategies for Network GWAS Evaluated Using Classroom Crowd Science. PMID:31022372
A Bioinformatics View of Glycan⁻Virus Interactions. PMID:31018588
Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition. PMID:31018575
Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis. PMID:31018140
YAP-independent mechanotransduction drives breast cancer progression. PMID:31015465
eIF4G2 balances its own mRNA translation via a PCBP2-based feedback loop. PMID:31010886
Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer. PMID:31003445
Transcriptome Analysis Revealed a Highly Connected Gene Module Associated With Cirrhosis to Hepatocellular Carcinoma Development. PMID:31001331
Targeting Tumor Vascular CD99 Inhibits Tumor Growth. PMID:31001265
Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask). PMID:30995798
Crystal structure of human RIOK2 bound to a specific inhibitor. PMID:30991936
Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability. PMID:30990168
Myometrial Transcriptional Signatures of Human Parturition. PMID:30988671
Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates. PMID:30988006
IFITM3: How genetics influence influenza infection demographically. PMID:30987701
Proteomic Analysis Implicates Vimentin in Glioblastoma Cell Migration. PMID:30987208
Increasing consensus of context-specific metabolic models by integrating data-inferred cell functions. PMID:30986217
Quantitative Proteomic Analysis of Human Seminal Plasma from Normozoospermic and Asthenozoospermic Individuals. PMID:30984777
Cell migration and proliferation are regulated by miR-26a in colorectal cancer via the PTEN-AKT axis. PMID:30983885
Tspan8 is expressed in breast cancer and regulates E-cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles. PMID:30982971
CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids. PMID:30982469
Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies. PMID:30974124
In silico Characterization of Human Prion-Like Proteins: Beyond Neurological Diseases. PMID:30971948
Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner. PMID:30971297
Systems Biology Reveals NR2F6 and TGFB1 as Key Regulators of Feed Efficiency in Beef Cattle. PMID:30967894
Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor. PMID:30965276
Analysis of the role of the Hippo pathway in cancer. PMID:30961610
Androgen deprivation therapy promotes an obesity-like microenvironment in periprostatic fat. PMID:30959474
In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta. PMID:30958262
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma. PMID:30957641
Proteomic studies of bone and skeletal health outcomes. PMID:30954730
Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects. PMID:30952858
Prognostic role of cyclin D2/D3 in multiple human malignant neoplasms: A systematic review and meta-analysis. PMID:30950241
Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory. PMID:30948719
Genome-wide Analysis of Common Copy Number Variation and Epithelial Ovarian Cancer Risk. PMID:30948450
Inflammation: A key process in skin tumorigenesis. PMID:30944600
Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles. PMID:30943406
BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers. PMID:30941229
Fetal lung C4BPA induces p100 processing in human placenta. PMID:30940885
The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. PMID:30930166
Evaluation and Interpretation of Transcriptome Data Underlying Heterogeneous Chronic Obstructive Pulmonary Disease. PMID:30929403
EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma. PMID:30923826
Serum endostatin levels are associated with diffusion capacity and with tuberous sclerosis- associated lymphangioleiomyomatosis. PMID:30922357
The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population. PMID:30920136
Multifactorial Contribution of Notch Signaling in Head and Neck Squamous Cell Carcinoma. PMID:30917608
Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator. PMID:30916349
Melanoma-Induced Reprogramming of Schwann Cell Signaling Aids Tumor Growth. PMID:30914431
Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients. PMID:30914425
Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis. PMID:30906868
Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1. PMID:30906261
Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning. PMID:30905848
Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage. PMID:30900988
Evolutionary and functional implications of 3' untranslated region length of mRNAs by comprehensive investigation among four taxonomically diverse metazoan species. PMID:30900191
Diagnostic and prognostic value of mRNA expression of phospholipase C β family genes in hepatitis B virus‑associated hepatocellular carcinoma. PMID:30896816
Comprehensive Analysis of Individual Variation in the Urinary Proteome Revealed Significant Gender Differences. PMID:30894400
Proteomic Analysis of Human Plasma during Intermittent Fasting. PMID:30892045
Hexosamine Biosynthetic Pathway and Glycosylation Regulate Cell Migration in Melanoma Cells. PMID:30891426
Identifying and exploiting gene-pathway interactions from RNA-seq data for binary phenotype. PMID:30890140
Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. PMID:30889382
Primate piRNA Cluster Evolution Suggests Limited Relevance of Pseudogenes in piRNA-Mediated Gene Regulation. PMID:30888404
Identification of Important Effector Proteins in the FOXJ1 Transcriptional Network Associated With Ciliogenesis and Ciliary Function. PMID:30881373
Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer. PMID:30875794
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy. PMID:30873179
Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis. PMID:30872636
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma. PMID:30872592
Regulation of proline-directed kinases and the trans-histone code H3K9me3/H4K20me3 during human myogenesis. PMID:30872405
netDx: interpretable patient classification using integrated patient similarity networks. PMID:30872331
β3 -Adrenoceptors in the normal and diseased urinary bladder-What are the open questions? PMID:30868554
Post-transcriptional regulatory patterns revealed by protein-RNA interactions. PMID:30867517
Aberrant DOCK2, GRASP, HIF3A and PKFP Hypermethylation has Potential as a Prognostic Biomarker for Prostate Cancer. PMID:30866497
A novel Microproteomic Approach Using Laser Capture Microdissection to Study Cellular Protrusions. PMID:30866487
A systematic review and standardized clinical validity assessment of male infertility genes. PMID:30865283
LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3. PMID:30858559
The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1. PMID:30858459
UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation. PMID:30858178
Clinical Stratification of High-Grade Ovarian Serous Carcinoma Using a Panel of Six Biomarkers. PMID:30857227
A network-based approach to identify DNA methylation and its involved molecular pathways in testicular germ cell tumors. PMID:30854095
Emerging drug development technologies targeting ubiquitination for cancer therapeutics. PMID:30851297
Increased LGALS3 expression independently predicts shorter overall survival in patients with the proneural subtype of glioblastoma. PMID:30848102
Genome-wide meta-analysis identifies novel loci associated with free triiodothyronine and thyroid-stimulating hormone. PMID:30843173
S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. PMID:30842656
HER2 Directed Antibody-Drug-Conjugates beyond T-DM1 in Breast Cancer. PMID:30841523
A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome. PMID:30840886
Geometric characterisation of disease modules. PMID:30839777
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion. PMID:30836712
Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle. PMID:30835510
Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion. PMID:30835257
Functional Modules of the Proteostasis Network. PMID:30833457
A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing. PMID:30829570
Regulation of Microbiota by Vitamin D Receptor: A Nuclear Weapon in Metabolic Diseases. PMID:30828578
Isoform-specific GSK3A activity is negatively correlated with human sperm motility. PMID:30824926
Selecting variants of unknown significance through network-based gene-association significantly improves risk prediction for disease-control cohorts. PMID:30824863
Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors. PMID:30823893
COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis. PMID:30819896
Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard. PMID:30819892
Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia. PMID:30819197
Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail. PMID:30818851
In silico analysis identified miRNA‑based therapeutic agents against glioblastoma multiforme. PMID:30816530
Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior. PMID:30814913
MicroRNAs from saliva of anopheline mosquitoes mimic human endogenous miRNAs and may contribute to vector-host-pathogen interactions. PMID:30814633
Comparative analyses of sperm DNA methylomes among human, mouse and cattle provide insights into epigenomic evolution and complex traits. PMID:30810461
Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells. PMID:30810435
NOD1: An Interface Between Innate Immunity and Insulin Resistance. PMID:30807635
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. PMID:30804560
Proteomic Maps of Human Gastrointestinal Stromal Tumor Subgroups. PMID:30804049
UBTD1 is a mechano-regulator controlling cancer aggressiveness. PMID:30804013
Cardiac β3 -adrenoceptors-A role in human pathophysiology? PMID:30801686
Clinical Transcriptome Sequencing Confirms Activation of a Cryptic Splice Site in Suspected SYNGAP1-Related Disorder. PMID:30800045
The Emerging World of TCR-T Cell Trials Against Cancer: A Systematic Review. PMID:30798772
Predicted secreted protein analysis reveals synaptogenic function of Clstn3 during WAT browning and BAT activation in mice. PMID:30796355
Genomic landscape of a metastatic malignant proliferating tricholemmal tumor and its response to PI3K inhibition. PMID:30793038
Down-regulation of FZD3 receptor suppresses growth and metastasis of human melanoma independently of canonical WNT signaling. PMID:30792348
Human colon organoids reveal distinct physiologic and oncogenic Wnt responses. PMID:30792186
Comprehensive clinical implications of homeobox A10 in 3,199 cases of non-small cell lung cancer tissue samples combining qRT-PCR, RNA sequencing and microarray data. PMID:30787969
MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon. PMID:30784582
Cellular Compartmentation and the Redox/Nonredox Functions of NAD. PMID:30784294
Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer. PMID:30781493
Molecular crypsis by pathogenic fungi using human factor H. A numerical model. PMID:30779817
Towards a data-integrated cell. PMID:30778056
Quantification and discovery of sequence determinants of protein-per-mRNA amount in 29 human tissues. PMID:30777893
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues. PMID:30777892
A Cholesterol Analog Induces an Oligomeric Reorganization of VDAC. PMID:30777305
Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas. PMID:30777055
The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation. PMID:30770239
Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring. PMID:30768568
Flotillin1 promotes EMT of human small cell lung cancer via TGF-β signaling pathway. PMID:30766750
MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma. PMID:30765601
Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. PMID:30760538
PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq. PMID:30759402
Survival in a bad neighborhood: pancreatic islets in cystic fibrosis. PMID:30759072
Identification of special key genes for alcohol-related hepatocellular carcinoma through bioinformatic analysis. PMID:30755830
Eradication of glioblastoma by immuno-virotherapy with a retargeted oncolytic HSV in a preclinical model. PMID:30755732
CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3. PMID:30755730
Integrated bioinformatics analysis of key genes involved in progress of colon cancer. PMID:30746900
SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro. PMID:30744170
Histamine N-Methyltransferase in the Brain. PMID:30744146
Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma. PMID:30736807
Predicting clinically promising therapeutic hypotheses using tensor factorization. PMID:30736745
Proteomic Atlas of the Human Brain in Alzheimer's Disease. PMID:30735395
The antimicrobial protein S100A12 identified as a potential autoantigen in a subgroup of atopic dermatitis patients. PMID:30728947
WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial-mesenchymal transition. PMID:30723155
PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling. PMID:30718277
Conserved regulation of RNA processing in somatic cell reprogramming. PMID:30704403
Heart failure in cancer: role of checkpoint inhibitors. PMID:30701100
Mass Spectrometry-based Absolute Quantification of 20S Proteasome Status for Controlled Ex-vivo Expansion of Human Adipose-derived Mesenchymal Stromal/Stem Cells. PMID:30700495
Detecting Secretory Proteins by Acoustic Droplet Ejection in Multiplexed High-Throughput Applications. PMID:30699290
Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion. PMID:30698726
Spatial Principles of Chromatin Architecture Associated With Organ-Specific Gene Regulation. PMID:30697540
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules. PMID:30693281
Cadherin 11 Inhibition Downregulates β-catenin, Deactivates the Canonical WNT Signalling Pathway and Suppresses the Cancer Stem Cell-Like Phenotype of Triple Negative Breast Cancer. PMID:30691241
Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4. PMID:30691220
Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. PMID:30685239
Are we listening to everything the PARK genes are telling us? PMID:30680728
NKL homeobox gene NKX2-2 is aberrantly expressed in Hodgkin lymphoma. PMID:30680064
A Retrospective Analysis of the Cartilage Kunitz Protease Inhibitory Proteins Identifies These as Members of the Inter-α-Trypsin Inhibitor Superfamily with Potential Roles in the Protection of the Articulatory Surface. PMID:30678366
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation. PMID:30674441
Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer. PMID:30670910
Gut microbiota profiling with differential tolerance against the reduced dietary fibre level in rabbit. PMID:30670754
PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights. PMID:30668673
miR663a‑TTC22V1 axis inhibits colon cancer metastasis. PMID:30664167
Mucosal IL13RA2 expression predicts nonresponse to anti-TNF therapy in Crohn's disease. PMID:30663072
Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression. PMID:30661928
Spatial proteomics: a powerful discovery tool for cell biology. PMID:30659282
Combining LOPIT with differential ultracentrifugation for high-resolution spatial proteomics. PMID:30659192
VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site. PMID:30657523
The RANK-RANKL axis: an opportunity for drug repurposing in cancer? PMID:30656607
RiboTag translatomic profiling of Drosophila oenocytes under aging and induced oxidative stress. PMID:30651069
Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis. PMID:30649494
Large-scale analysis of human gene expression variability associates highly variable drug targets with lower drug effectiveness and safety. PMID:30649201
Elucidation of the functional roles of the Q and I motifs in the human chromatin-remodeling enzyme BRG1. PMID:30647132
Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation. PMID:30639098
Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target. PMID:30635167
Leveraging Multilayered "Omics" Data for Atopic Dermatitis: A Road Map to Precision Medicine. PMID:30631320
Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis. PMID:30629778
Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy. PMID:30628708
Organoid single cell profiling identifies a transcriptional signature of glomerular disease. PMID:30626756
Variations in HPV function are associated with survival in squamous cell carcinoma. PMID:30626753
Cancer Connectors: Connexins, Gap Junctions, and Communication. PMID:30622930
Wireless Electrochemical Detection on a Microfluidic Compact Disc (CD) and Evaluation of Redox-Amplification during Flow. PMID:30621031
The Importance of Biologic Knowledge and Gene Expression Context for Genomic Data Interpretation. PMID:30619486
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. PMID:30617275
Systems-based approaches for investigation of inter-tissue communication. PMID:30617149
Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis. PMID:30606699
The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens. PMID:30606230
Clinical significance and biological role of cancer-derived Type I collagen in lung and esophageal cancers. PMID:30604926
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies. PMID:30604766
A region-resolved mucosa proteome of the human stomach. PMID:30604760
Alterations in sialic-acid O-acetylation glycoforms during murine erythrocyte development. PMID:30597004
miR‑675 promotes colorectal cancer cell growth dependent on tumor suppressor DMTF1. PMID:30592263
Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus. PMID:30591584
The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass. PMID:30588560
Oncogenic Role of Tumor Necrosis Factor α-Induced Protein 8 (TNFAIP8). PMID:30586922
Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community. PMID:30580566
Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients. PMID:30578919
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. PMID:30578418
A locus on chromosome 5 shows African ancestry-limited association with alloimmunization in sickle cell disease. PMID:30578281
Novel circular RNA circNF1 acts as a molecular sponge, promoting gastric cancer by absorbing miR-16. PMID:30576282
Calmodulinopathy: A Novel, Life-Threatening Clinical Entity Affecting the Young. PMID:30574507
Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells. PMID:30573509
Proteomic Analysis of the Human Anterior Pituitary Gland. PMID:30571610
Cell Hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics. PMID:30567574
NAD Metabolome Analysis in Human Cells Using ¹H NMR Spectroscopy. PMID:30563212
Diagnosing rare diseases after the exome. PMID:30559314
Intrinsic Dynamics of a Human Gene Reveal the Basis of Expression Heterogeneity. PMID:30554876
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis. PMID:30554520
How many cadherins do human endothelial cells express? PMID:30552441
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. PMID:30552067
B cells in esophago-gastric adenocarcinoma are highly differentiated, organize in tertiary lymphoid structures and produce tumor-specific antibodies. PMID:30546950
Targeted Delivery of TNF Potentiates the Antibody-Dependent Cell-Mediated Cytotoxicity of an Anti-Melanoma Immunoglobulin. PMID:30543899
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. PMID:30542056
Analysis of 3D genomic interactions identifies candidate host genes that transposable elements potentially regulate. PMID:30541598
PopViz: a webserver for visualizing minor allele frequencies and damage prediction scores of human genetic variations. PMID:30535305
Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease. PMID:30533169
Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition. PMID:30532030
Loss of Ca2+/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease. PMID:30525042
Borders of Cis-Regulatory DNA Sequences Preferentially Harbor the Divergent Transcription Factor Binding Motifs in the Human Genome. PMID:30524473
Proteome-wide Tyrosine Phosphorylation Analysis Reveals Dysregulated Signaling Pathways in Ovarian Tumors. PMID:30523211
The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland. PMID:30520817
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. PMID:30518876
Stable-protein Pair Analysis as A Novel Strategy to Identify Proteomic Signatures: Application To Seminal Plasma From Infertile Patients. PMID:30518674
Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing. PMID:30514914
The Role of Cystinosin in the Intermediary Thiol Metabolism and Redox Homeostasis in Kidney Proximal Tubular Cells. PMID:30513914
Molecular characterization and biomarker identification in colorectal cancer: Toward realization of the precision medicine dream. PMID:30510457
Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin. PMID:30508377
The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes. PMID:30504233
2C-BioID: An Advanced Two Component BioID System for Precision Mapping of Protein Interactomes. PMID:30500481
Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems. PMID:30487642
Novel in Vitro Method Reveals Drugs That Inhibit Organic Solute Transporter Alpha/Beta (OSTα/β). PMID:30481467
Identification of RPL5 and RPL10 as novel diagnostic biomarkers of Atypical teratoid/rhabdoid tumors. PMID:30479569
Prostate-specific markers to identify rare prostate cancer cells in liquid biopsies. PMID:30479377
Pooled extracellular receptor-ligand interaction screening using CRISPR activation. PMID:30477585
Frailty Index associates with GRIN2B in two representative samples from the United States and the United Kingdom. PMID:30475886
FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer. PMID:30475207
Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma. PMID:30471425
A HS6ST2 gene variant associated with X-linked intellectual disability and severe myopia in two male twins. PMID:30471091
Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer. PMID:30470719
Protocadherin-1 is essential for cell entry by New World hantaviruses. PMID:30464266
Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium. PMID:30464253
Integration of transcriptome and proteome profiles in glioblastoma: looking for the missing link. PMID:30463513
Tissue-Based Mapping of the Fathead Minnow (Pimephales promelas) Transcriptome and Proteome. PMID:30459712
Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson's Disease and Synucleinopathies. PMID:30459551
CAARS: comparative assembly and annotation of RNA-Seq data. PMID:30452539
Characterization of the F-box Proteins FBXW2 and FBXL14 in the Initiation of Bone Regeneration in Transplants given to Nude Mice. PMID:30450135
Methylation-Based Classification of Cervical Squamous Cell Carcinoma into Two New Subclasses Differing in Immune-Related Gene Expression. PMID:30445744
The expression signature of cancer-associated KRAB-ZNF factors identified in TCGA pan-cancer transcriptomic data. PMID:30444046
Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes. PMID:30443895
Gene expression profile of muscle adaptation to high-intensity intermittent exercise training in young men. PMID:30429512
Identification of TEX101-associated Proteins Through Proteomic Measurement of Human Spermatozoa Homozygous for the Missense Variant rs35033974. PMID:30429210
funcExplorer: a tool for fast data-driven functional characterisation of high-throughput expression data. PMID:30428831
The Body-wide Transcriptome Landscape of Disease Models. PMID:30428375
Diabetes in Pregnancy and MicroRNAs: Promises and Limitations in Their Clinical Application. PMID:30424584
miRNA Mediated Noise Making of 3'UTR Mutations in Cancer. PMID:30424545
UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma. PMID:30420903
PTMiner: Localization and Quality Control of Protein Modifications Detected in an Open Search and Its Application to Comprehensive Post-translational Modification Characterization in Human Proteome. PMID:30420486
Bi-allelic POLR3A Loss-of-Function Variants Cause Autosomal-Recessive Wiedemann-Rautenstrauch Syndrome. PMID:30414627
Identifying a Novel Biomarker TOP2A of Clear Cell Renal Cell Carcinoma (ccRCC) Associated with Smoking by Co-Expression Network Analysis. PMID:30410595
Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs. PMID:30410047
Up-regulation of collagen proteins in colorectal liver metastasis compared with normal liver tissue. PMID:30409905
Identification of Core Biomarkers Associated with Outcome in Glioma: Evidence from Bioinformatics Analysis. PMID:30405856
A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer. PMID:30405805
Multivalent activation of GLP-1 and sulfonylurea receptors modulates β-cell second-messenger signaling and insulin secretion. PMID:30404557
Exploring Seipin: From Biochemistry to Bioinformatics Predictions. PMID:30402103
Regulation of Connexin32 by ephrin receptors and T-cell protein-tyrosine phosphatase. PMID:30401746
MitoMiner v4.0: an updated database of mitochondrial localization evidence, phenotypes and diseases. PMID:30398659
Perturbations of Neuron-Restrictive Silencing Factor Modulate Corticotropin-Releasing Hormone Gene Expression in the Human Cell Line BeWo. PMID:30397598
Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism. PMID:30397099
Host Peptidic Hormones Affecting Bacterial Biofilm Formation and Virulence. PMID:30396172
Comparative transcriptomics identifies genes differentially expressed in the intestine of a new fast-growing strain of common carp with higher unsaturated fatty acid content in muscle. PMID:30395585
Vitamin D stimulates multiple microRNAs to inhibit CRH and other pro-labor genes in human placenta. PMID:30395535
Integrated Epigenetic Mapping of Human and Mouse Salivary Gene Regulation. PMID:30392435
Laser capture microdissection-targeted mass spectrometry: a method for multiplexed protein quantification within individual layers of the cerebral cortex. PMID:30390066
X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family. PMID:30389958
Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects. PMID:30388400
HAVCR1 expression might be a novel prognostic factor for gastric cancer. PMID:30388143
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro. PMID:30387835
Proteomic profiling of liver tissue from the mdx-4cv mouse model of Duchenne muscular dystrophy. PMID:30386187
Detection of Shared Balancing Selection in the Absence of Trans-Species Polymorphism. PMID:30380122
From Single Level Analysis to Multi-Omics Integrative Approaches: A Powerful Strategy towards the Precision Oncology. PMID:30373182
Functional analysis of mammalian phospholipase D enzymes. PMID:30369483
CamurWeb: a classification software and a large knowledge base for gene expression data of cancer. PMID:30367574
Effect of equiaxial cyclic strain on cardiomyogenic induction in mesenchymal stem cells. PMID:30367393
Antiviral activity of the mineralocorticoid receptor NR3C2 against Herpes simplex virus Type 1 (HSV-1) infection. PMID:30367157
Targeted Analysis of Serum Proteins Encoded at Known Inflammatory Bowel Disease Risk Loci. PMID:30358838
BitterDB: taste ligands and receptors database in 2019. PMID:30357384
Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth. PMID:30356100
Druggability of Coronary Artery Disease Risk Loci. PMID:30354342
ACTA1 Novel Likely Pathogenic Variant in a Family With Dilated Cardiomyopathy. PMID:30354303
Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer. PMID:30349298
TissueEnrich: Tissue-specific gene enrichment analysis. PMID:30346488
Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions. PMID:30345971
Missense Mutations of the Pro65 Residue of PCGF2 Cause a Recognizable Syndrome Associated with Craniofacial, Neurological, Cardiovascular, and Skeletal Features. PMID:30343942
Aberrant PRDM9 expression impacts the pan-cancer genomic landscape. PMID:30341163
Evaluation of PACE4 isoforms as biomarkers in thyroid cancer. PMID:30340539
Novel MXD4-NUTM1 fusion transcript identified in primary ovarian undifferentiated small round cell sarcoma. PMID:30338611
IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line. PMID:30338032
Rapamycin in ischemic stroke: Old drug, new tricks? PMID:30334673
Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs. PMID:30333515
A Comparative Assessment of Human and Chimpanzee iPSC-derived Cardiomyocytes with Primary Heart Tissues. PMID:30333510
LncBook: a curated knowledgebase of human long non-coding RNAs. PMID:30329098
Interleukin 30 to Interleukin 40. PMID:30328794
Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients. PMID:30323977
ESS: A Tool for Genome-Scale Quantification of Essentiality Score for Reaction/Genes in Constraint-Based Modeling. PMID:30323767
Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma. PMID:30322894
Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs. PMID:30319685
The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease. PMID:30319631
Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts. PMID:30319613
Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins. PMID:30316580
Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN-FOS at composite DNA sites. PMID:30315111
Human Testis Extracellular Matrix Enhances Human Spermatogonial Stem Cell Survival In Vitro. PMID:30311859
Shortening of apparent transverse relaxation time of inorganic phosphate as a breast cancer biomarker. PMID:30311703
Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization. PMID:30309985
Comparison of breast cancer metastasis models reveals a possible mechanism of tumor aggressiveness. PMID:30305609
Human DREF/ZBED1 is a nuclear protein widely expressed in multiple cell types derived from all three primary germ layers. PMID:30304065
Histone Deacetylase Inhibition Has Targeted Clinical Benefit in ARID1A-Mutated Advanced Urothelial Carcinoma. PMID:30301863
Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations. PMID:30301787
Interface-Based Structural Prediction of Novel Host-Pathogen Interactions. PMID:30298406
Enhanced validation of antibodies for research applications. PMID:30297845
Haplosaurus computes protein haplotypes for use in precision drug design. PMID:30297836
Impact of chemotactic factors and receptors on the cancer immune infiltrate: a bioinformatics study revealing homogeneity and heterogeneity among patient cohorts. PMID:30288345
Prediction of gene regulatory enhancers across species reveals evolutionarily conserved sequence properties. PMID:30286077
Autoantibodies Against Perilipin 1 as a Cause of Acquired Generalized Lipodystrophy. PMID:30283460
Guidance Molecules in Vascular Smooth Muscle. PMID:30283356
Colonic epithelial miR-31 associates with the development of Crohn's phenotypes. PMID:30282822
A non-coding region near Follistatin controls head colour polymorphism in the Gouldian finch. PMID:30282656
A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein. PMID:30279450
psichomics: graphical application for alternative splicing quantification and analysis. PMID:30277515
Application of weighted gene co-expression network analysis to identify key modules and hub genes in oral squamous cell carcinoma tumorigenesis. PMID:30275705
Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease. PMID:30275566
Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline. PMID:30275468
Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma. PMID:30272346
Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research. PMID:30271982
Launching the C-HPP neXt-CP50 Pilot Project for Functional Characterization of Identified Proteins with No Known Function. PMID:30269496
Short Leucine-Rich Proteoglycans Modulate Complement Activity and Increase Killing of the Respiratory Pathogen Moraxella catarrhalis. PMID:30266767
Structure and Protein Interaction-Based Gene Ontology Annotations Reveal Likely Functions of Uncharacterized Proteins on Human Chromosome 17. PMID:30265558
A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder. PMID:30262571
Epigenetic Study in Parkinson's Disease: A Pilot Analysis of DNA Methylation in Candidate Genes in Brain. PMID:30261625
A short isoform of ATG7 fails to lipidate LC3/GABARAP. PMID:30258106
The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. PMID:30251625
A meta-analysis and bioinformatics exploration of the diagnostic value and molecular mechanism of miR-193a-5p in lung cancer. PMID:30250529
Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes. PMID:30250408
Optimisation of a serum albumin removal protocol for use in a proteomic study to identify the protein biomarkers for silent gastric ulceration in horses. PMID:30250392
A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach. PMID:30249792
Vimentin Diversity in Health and Disease. PMID:30248895
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome. PMID:30242179
Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer. PMID:30241606
Functional and phylogenetic characterization of noncanonical vitamin B12-binding proteins in zebrafish suggests involvement in cobalamin transport. PMID:30237171
Emerging Developments in Microbiome and Microglia Research: Implications for Neurodevelopmental Disorders. PMID:30233586
Absence of AIF1L contributes to cell migration and a poor prognosis of breast cancer. PMID:30233209
SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer. PMID:30231985
Large-scale investigation of the reasons why potentially important genes are ignored. PMID:30226837
Translational molecular imaging in exocrine pancreatic cancer. PMID:30225616
sox9b is required in cardiomyocytes for cardiac morphogenesis and function. PMID:30224706
Downregulation of FOXK2 is associated with poor prognosis in patients with gastric cancer. PMID:30221666
Frequency and signature of somatic variants in 1461 human brain exomes. PMID:30214067
Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation. PMID:30214039
ADAP1 limits neonatal cardiomyocyte hypertrophy by reducing integrin cell surface expression. PMID:30206251
A Computational Method for Classifying Different Human Tissues with Quantitatively Tissue-Specific Expressed Genes. PMID:30205473
Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD. PMID:30202070
Terminal exon characterization with TECtool reveals an abundance of cell-specific isoforms. PMID:30202060
Cell type-resolved human lung lipidome reveals cellular cooperation in lung function. PMID:30194354
Neuronal pentraxin receptor-1 is a new cerebrospinal fluid biomarker of Alzheimer's disease progression. PMID:30191060
xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction. PMID:30190786
Cross-tissue eQTL enrichment of associations in schizophrenia. PMID:30188921
The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer. PMID:30188895
Integrated measurement of intracellular proteins and transcripts in single cells. PMID:30178802
Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage. PMID:30175270
Study of mitotic chromatin supports a model of bookmarking by histone modifications and reveals nucleosome deposition patterns. PMID:30166406
Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney. PMID:30166318
Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer. PMID:30161001
Selenium-Encoded Isotopic Signature Targeted Profiling. PMID:30159393
Anti-ARHGAP26 Autoantibodies Are Associated With Isolated Cognitive Impairment. PMID:30158896
Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP. PMID:30158653
Region-Resolved Quantitative Proteome Profiling Reveals Molecular Dynamics Associated With Chronic Pain in the PNS and Spinal Cord. PMID:30154697
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes. PMID:30154505
MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology. PMID:30153342
Exploring the Role of Fallopian Ciliated Cells in the Pathogenesis of High-Grade Serous Ovarian Cancer. PMID:30149579
Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ. PMID:30135298
DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride. PMID:30132517
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. PMID:30125269
Chronic Adrenergic Signaling Causes Abnormal RNA Expression of Proliferative Genes in Fetal Sheep Islets. PMID:30124804
Prediagnostic circulating markers of inflammation and risk of oesophageal adenocarcinoma: a study within the National Cancer Institute Cohort Consortium. PMID:30121626
Na/K-ATPase Y260 Phosphorylation-mediated Src Regulation in Control of Aerobic Glycolysis and Tumor Growth. PMID:30120256
Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma. PMID:30119675
Identification of non-mutated neoantigens presented by TAP-deficient tumors. PMID:30115740
Systems level expression correlation of Ras GTPase regulators. PMID:30111366
Identification of pathways and genes associated with cerebral palsy. PMID:30109564
Approaches to target tractability assessment - a practical perspective. PMID:30108951
Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins. PMID:30108415
Proteomics: Clinical and research applications in respiratory diseases. PMID:30105802
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms. PMID:30101371
Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project. PMID:30099871
Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies. PMID:30097533
Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers. PMID:30090875
Proteomic distinction of renal oncocytomas and chromophobe renal cell carcinomas. PMID:30087584
CTCF maintains regulatory homeostasis of cancer pathways. PMID:30086769
FBXW7: a critical tumor suppressor of human cancers. PMID:30086763
Antibody validation: a view from the mountains. PMID:30086383
Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum. PMID:30086131
On the problem of confounders in modeling gene expression. PMID:30084962
A tissue-based draft map of the murine MHC class I immunopeptidome. PMID:30084848
Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours. PMID:30082739
Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor. PMID:30082484
A secretome profile indicative of oleate-induced proliferation of HepG2 hepatocellular carcinoma cells. PMID:30076294
ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport. PMID:30076131
Smoking-induced iron dysregulation in the lung. PMID:30075191
Bi-allelic Recessive Loss-of-Function Variants in FANCM Cause Non-obstructive Azoospermia. PMID:30075111
Familial Cancer Variant Prioritization Pipeline version 2 (FCVPPv2) applied to a papillary thyroid cancer family. PMID:30072699
Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma. PMID:30072578
Co-regulatory networks of human serum proteins link genetics to disease. PMID:30072576
Mechanistic Insights into CpG DNA and IL-15 Synergy in Promoting B Cell Chronic Lymphocytic Leukemia Clonal Expansion. PMID:30068596
Prognostic values of the inhibitor of DNA‑binding family members in breast cancer. PMID:30066902
Bacterial Outer Membrane Vesicles Induce Vitronectin Release Into the Bronchoalveolar Space Conferring Protection From Complement-Mediated Killing. PMID:30061873
Amelioration of Diabetic Nephropathy Using a Retinoic Acid Receptor β2 Agonist. PMID:30054312
BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery. PMID:30053270
Characterization of FGD5 Expression in Primary Breast Cancers and Lymph Node Metastases. PMID:30052477
Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts. PMID:30052023
Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways. PMID:30050127
Inhibitors of lysosomal function or serum starvation in control or LAMP2 deficient cells do not modify the cellular levels of Parkinson disease-associated DJ-1/PARK 7 protein. PMID:30048497
Identification of integrin drug targets for 17 solid tumor types. PMID:30046394
Liver-enriched Genes are Associated with the Prognosis of Patients with Hepatocellular Carcinoma. PMID:30046116
Epigenetic Variability Confounds Transcriptome but Not Proteome Profiling for Coexpression-based Gene Function Prediction. PMID:30042154
Age-Related Differential Structural and Transcriptomic Responses in the Hypertensive Heart. PMID:30038575
Appetite, Metabolism and Hormonal Regulation in Normal Ageing and Dementia. PMID:30036957
Transferrin receptor 1 in cancer: a new sight for cancer therapy. PMID:30034931
Targeting Pim Kinases and DAPK3 to Control Hypertension. PMID:30033129
VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival. PMID:30027561
Chemical and genetic control of IFNγ-induced MHCII expression. PMID:30021835
Alzheimer disease pathology and the cerebrospinal fluid proteome. PMID:30021611
A Universal Live Cell Barcoding-Platform for Multiplexed Human Single Cell Analysis. PMID:30018331
Downregulation of miR‑486‑5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing. PMID:30015845
Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk. PMID:30013180
A meta-analysis of transcriptome datasets characterizes malignant transformation from melanocytes and nevi to melanoma. PMID:30008882
Functional characteristics of novel pancreatic Pax6 regulatory elements. PMID:30007277
Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers. PMID:29997511
Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21. PMID:29997282
Lack of evidence for a causal role of CALR3 in monogenic cardiomyopathy. PMID:29988065
Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma. PMID:29987839
Silencing NIK potentiates anti-VEGF therapy in a novel 3D model of colorectal cancer angiogenesis. PMID:29983872
A Screening Rule for ℓ1-Regularized Ising Model Estimation. PMID:29983538
Loose ends: almost one in five human genes still have unresolved coding status. PMID:29982784
Epithelial origin of eosinophilic esophagitis. PMID:29980278
Creation of a myosin Va-TAP-tagged mouse and identification of potential myosin Va-interacting proteins in the cerebellum. PMID:29979496
ABRF Proteome Informatics Research Group (iPRG) 2016 Study: Inferring Proteoforms from Bottom-up Proteomics Data. PMID:29977167
Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer. PMID:29975776
MicroRNA interactome analysis predicts post-transcriptional regulation of ADRB2 and PPP3R1 in the hypercholesterolemic myocardium. PMID:29973623
Actionable Metabolic Pathways in Heart Failure and Cancer-Lessons From Cancer Cell Metabolism. PMID:29971237
Differential Integration of Transcriptome and Proteome Identifies Pan-Cancer Prognostic Biomarkers. PMID:29971090
Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15. PMID:29970016
Enteric Species F Human Adenoviruses use Laminin-Binding Integrins as Co-Receptors for Infection of Ht-29 Cells. PMID:29968781
Six novel susceptibility loci for coronary artery disease and cerebral infarction identified by longitudinal exome-wide association studies in a Japanese population. PMID:29963304
Genome sequencing as a first-line genetic test in familial dilated cardiomyopathy. PMID:29961767
xMD-miRNA-seq to generate near in vivo miRNA expression estimates in colon epithelial cells. PMID:29955168
Quantitative Proteomic Analysis Identifies AHNAK (Neuroblast Differentiation-associated Protein AHNAK) as a Novel Candidate Biomarker for Bladder Urothelial Carcinoma Diagnosis by Liquid-based Cytology. PMID:29950347
NF-kappaB Regulates Redox Status in Breast Cancer Subtypes. PMID:29949949
Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency. PMID:29949756
Quantification of Inflammasome Adaptor Protein ASC in Biological Samples by Multiple-Reaction Monitoring Mass Spectrometry. PMID:29948504
Presence of growth/differentiation factor-15 cytokine in human follicular fluid, granulosa cells, and oocytes. PMID:29948426
Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population. PMID:29945935
The arrhythmogenic cardiomyopathy-specific coding and non-coding transcriptome in human cardiac stromal cells. PMID:29940860
TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis. PMID:29940807
Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources. PMID:29931155
Regulation of Gastric Lgr5+ve Cell Homeostasis by Bone Morphogenetic Protein (BMP) Signaling and Inflammatory Stimuli. PMID:29930977
Molecular insights into cardiomyopathies associated with desmin (DES) mutations. PMID:29926427
Loss of the basic helix-loop-helix transcription factor Bhlhe41 induces cell death and impairs neurite outgrowth in Neuro2a cells. PMID:29926321
Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors. PMID:29925909
Circulating MicroRNAs: a Potential Biomarker for Cardiac Damage, Inflammatory Response, and Left Ventricular Function Recovery in Pediatric Viral Myocarditis. PMID:29916103
Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond-like syndrome. PMID:29914977
Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review. PMID:29910734
Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas. PMID:29909548
Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development. PMID:29907769
FOXA2 promotes the proliferation, migration and invasion, and epithelial mesenchymal transition in colon cancer. PMID:29896233
A homozygous FANCM frameshift pathogenic variant causes male infertility. PMID:29895858
Brain Cell Type Specific Gene Expression and Co-expression Network Architectures. PMID:29892006
TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer. PMID:29891505
A Computational Approach for Prioritizing Selection of Therapies Targeting Drug Resistant Variation in Anaplastic Lymphoma Kinase. PMID:29888064
A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits. PMID:29887380
Papillomavirus E2 protein is regulated by specific fibroblast growth factor receptors. PMID:29885490
Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies. PMID:29884306
Re-Evaluating E-Cadherin and β-Catenin: A Pan-Cancer Proteomic Approach with an Emphasis on Breast Cancer. PMID:29879416
The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses. PMID:29875205
Changing Trends in Computational Drug Repositioning. PMID:29874824
Precision histology: how deep learning is poised to revitalize histomorphology for personalized cancer care. PMID:29872706
The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment. PMID:29872573
GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. PMID:29872392