Human Protein Atlas
Names
More detailed information about this field from each metasource.
Human Protein Atlas
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
HPA
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2019-01-14; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2021-04-07
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
The Human Protein Atlas
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2019-01-14; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2021-04-07
metasource: bio.tools
version: extracted_at: 2021-04-07T11:58:51.652474
proteinatlas
metasource: bio.tools
version: extracted_at: 2021-04-07T11:58:51.652474
Names
More detailed information about this field from each metasource.
Human Protein Atlas
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
HPA
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2019-01-14; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2021-04-07
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
The Human Protein Atlas
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2019-01-14; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2021-04-07
metasource: bio.tools
version: extracted_at: 2021-04-07T11:58:51.652474
proteinatlas
metasource: bio.toolsversion: extracted_at: 2021-04-07T11:58:51.652474
Other names: HPA, The Human Protein Atlas, proteinatlas
Names
More detailed information about this field from each metasource.
Human Protein Atlas
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
HPA
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2019-01-14; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2021-04-07
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
The Human Protein Atlas
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2019-01-14; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2021-04-07
metasource: bio.tools
version: extracted_at: 2021-04-07T11:58:51.652474
proteinatlas
metasource: bio.toolsversion: extracted_at: 2021-04-07T11:58:51.652474
The Human Protein Atlas is program started with the aim to map of all the human proteins in cells, tissues and organs using integration of various omics technologies. It consists of three parts: Tissue Atlas showing the distribution of proteins across tissues and organs in the human body, the Cell Atlas showing the subcellular localization of proteins in single cells and Pathology Atlas showing the impact of protein levels for survival of patients with cancer.
Description
More detailed information about this field from each metasource.
The Human Protein Atlas is program started with the aim to map of all the human proteins in cells, tissues and organs using integration of various omics technologies. It consists of three parts: Tissue Atlas showing the distribution of proteins across tissues and organs in the human body, the Cell Atlas showing the subcellular localization of proteins in single cells and Pathology Atlas showing the impact of protein levels for survival of patients with cancer.
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2021-04-07T15:31:37.666880
The Human Protein Atlas (HPA) portal is a publicly available database with millions of high-resolution images showing the spatial distribution of proteins in a number of different wild-type tissues, cancer types and human cell lines. The goal of the HPA is to map all the human proteins in cells, tissues and organs using an integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics and systems biology. The HPA is composed of six parts: the Tissue Atlas, the Single Cell Type Atlas, the Pathology Atlas, the Blood Atlas, the Brain Atlas, and the Cell Atlas.
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
The Swedish Human Protein Atlas project has been set up to allow for a systematic exploration of the human proteome using Antibody-Based Proteomics. This is accomplished by combining high-throughput generation of affinity-purified antibodies with protein profiling in a multitude of tissues and cells assembled in tissue microarrays. Confocal microscopy analysis using human cell lines is performed for more detailed protein localization. The program hosts the Human Protein Atlas portal with expression profiles of human proteins in tissues and cells. The main objective of the resource centre is to produce specific antibodies to human target proteins using a high-throughput production method involving the cloning and protein expression of Protein Epitope Signature Tags (PrESTs). After purification, the antibodies are used to study expression profiles in cells and tissues and for functional analysis of the corresponding proteins in a wide range of platforms.
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2019-01-14; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2021-04-07
Database with millions of high-resolution images. Expression and localization of proteins in a large variety of normal human tissues, cancer cells and cell lines with the aid of immunohistochemistry (IHC) images and immunofluorescence (IF) confocal microscopy images.
metasource: bio.toolsversion: extracted_at: 2021-04-07T11:58:51.652474
Webpage:
https://www.proteinatlas.orgWebpage
More detailed information about this field from each metasource.
https://www.proteinatlas.org
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2021-04-07T15:31:37.666880
https://www.proteinatlas.org/
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
http://www.proteinatlas.org/
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2019-01-14; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2021-04-07
metasource: bio.tools
version: extracted_at: 2021-04-07T11:58:51.652474
Licence:
Name: Creative Commons Attribution-ShareAlike v3.0Licence name
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Creative Commons Attribution-ShareAlike v3.0
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2021-04-07T15:31:37.666880
Creative Commons Attribution-ShareAlike 3.0 Unported (CC BY-SA 3.0)
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
other
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2019-01-14; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2021-04-07
Licence URL
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https://www.proteinatlas.org/about/licence
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2021-04-07T15:31:37.666880
https://creativecommons.org/licenses/by-sa/3.0/
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
http://www.proteinatlas.org/about/licence
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2019-01-14; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2021-04-07
Publications:
(11)
Publications
More detailed information about this field from each metasource.
Proteomics. Tissue-based map of the human proteome
PMID: 25613900
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
Towards a knowledge-based Human Protein Atlas
PMID: 21139605
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
A pathology atlas of the human cancer transcriptome
PMID: 28818916
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
A human protein atlas for normal and cancer tissues based on antibody proteomics
PMID: 16127175
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
A subcellular map of the human proteome
PMID: 28495876
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
A genecentric Human Protein Atlas for expression profiles based on antibodies
PMID: 18669619
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
Transcriptomics resources of human tissues and organs
PMID: 27044256
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
Towards a knowledge-based Human Protein Atlas
PMID: 21139605
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
A human protein atlas for normal and cancer tissues based on antibody proteomics
PMID: 16127175
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
The Human Protein Atlas--a tool for pathology
PMID: 18853439
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
http://dx.doi.org/10.1126/science.1260419
metasource: bio.tools
version: extracted_at: 2021-04-07T11:58:51.652474
Publications
More detailed information about this field from each metasource.
Proteomics. Tissue-based map of the human proteome
PMID: 25613900
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
Towards a knowledge-based Human Protein Atlas
PMID: 21139605
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
A pathology atlas of the human cancer transcriptome
PMID: 28818916
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
A human protein atlas for normal and cancer tissues based on antibody proteomics
PMID: 16127175
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
A subcellular map of the human proteome
PMID: 28495876
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2021-04-07T15:31:37.666880
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
A genecentric Human Protein Atlas for expression profiles based on antibodies
PMID: 18669619
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
Transcriptomics resources of human tissues and organs
PMID: 27044256
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
Towards a knowledge-based Human Protein Atlas
PMID: 21139605
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
A human protein atlas for normal and cancer tissues based on antibody proteomics
PMID: 16127175
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
The Human Protein Atlas--a tool for pathology
PMID: 18853439
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Apr 07 2021 11:37 a.m.
http://dx.doi.org/10.1126/science.1260419
metasource: bio.toolsversion: extracted_at: 2021-04-07T11:58:51.652474
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Proteomics. Tissue-based map of the human proteome
PubMed citations: 2905.
2905 articles citing: Proteomics. Tissue-based map of the human proteome
Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population. PMID:33517564
Peroxisomal Metabolite and Cofactor Transport in Humans. PMID:33505966
circRNA circ_102049 Implicates in Pancreatic Ductal Adenocarcinoma Progression through Activating CD80 by Targeting miR-455-3p. PMID:33505218
Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility. PMID:33504897
Multi-organ proteomic landscape of COVID-19 autopsies. PMID:33503446
Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine. PMID:33501433
Monocytes carrying GFAP detect glioma, brain metastasis and ischaemic stroke, and predict glioblastoma survival. PMID:33501422
HPAStainR: a Bioconductor and Shiny app to query protein expression patterns in the Human Protein Atlas. PMID:33500778
Olfactory marker protein interacts with adenosine nucleotide derivatives. PMID:33490644
Integrative Expression and Prognosis Analysis of DHX37 in Human Cancers by Data Mining. PMID:33490273
Data-Driven Discovery of Molecular Targets for Antibody-Drug Conjugates in Cancer Treatment. PMID:33490264
Transcriptomic and Network Analysis of Minor Salivary Glands of Patients With Primary Sjögren's Syndrome. PMID:33488608
Growth Hormone and Neuronal Hemoglobin in the Brain-Roles in Neuroprotection and Neurodegenerative Diseases. PMID:33488521
Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model. PMID:33483609
Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases. PMID:33479664
Study of the active ingredients and mechanism of Sparganii rhizoma in gastric cancer based on HPLC-Q-TOF-MS/MS and network pharmacology. PMID:33479376
Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma. PMID:33479234
Proteomics analysis of a human brain sample from a mucolipidosis type IV patient reveals pathophysiological pathways. PMID:33478506
Suprabasin-A Review. PMID:33477529
Diet and PPARG2 Pro12Ala Polymorphism Interactions in Relation to Cancer Risk: A Systematic Review. PMID:33477496
The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk. PMID:33476202
Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate. PMID:33473133
Terminal Deoxynucleotidyl Transferase Commonly Expresses in Germ Cell Tumors: Evaluation on a Large Series from Multiple Centers. PMID:33469349
Prognostic role of PHYH for overall survival (OS) in clear cell renal cell carcinoma (ccRCC). PMID:33468235
Functional Evaluation of a Rare Variant c.516G>C (p.Trp172Cys) in the GJB2 (Connexin 26) Gene Associated with Nonsyndromic Hearing Loss. PMID:33466560
Calcium-Dependent Translocation of S100B Is Facilitated by Neurocalcin Delta. PMID:33466232
Identification of potential biomarkers of peripheral blood mononuclear cell in hepatocellular carcinoma using bioinformatic analysis: A protocol for systematic review and meta-analysis. PMID:33466191
Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach. PMID:33462259
Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model. PMID:33456582
The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases? PMID:33451033
CARD8 and IL1B Polymorphisms Influence MRI Brain Patterns in Newborns with Hypoxic-Ischemic Encephalopathy Treated with Hypothermia. PMID:33445495
Increased expression of CELSR3 indicates a poor prognostic factor for Prostate Cancer. PMID:33442409
Human leukocyte antigen class II quantification by targeted mass spectrometry in dendritic-like cell lines and monocyte-derived dendritic cells. PMID:33441579
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients. PMID:33441124
Longitudinal saliva omics responses to immune perturbation: a case study. PMID:33436912
CHD2-Related CNS Pathologies. PMID:33435571
GPR55 Receptor Activation by the N-Acyl Dopamine Family Lipids Induces Apoptosis in Cancer Cells via the Nitric Oxide Synthase (nNOS) Over-Stimulation. PMID:33435517
Of numbers and movement - understanding transcription factor pathogenesis by advanced microscopy. PMID:33433399
The secretome mouse provides a genetic platform to delineate tissue-specific in vivo secretion. PMID:33431665
Experimental Models to Study COVID-19 Effect in Stem Cells. PMID:33430424
Variants in PPP2R2B and IGF2BP3 are associated with higher tau deposition. PMID:33426524
Alpha2-Antiplasmin: The Devil You Don't Know in Cerebrovascular and Cardiovascular Disease. PMID:33426005
In Search of Zonation Markers to Identify Liver Functional Disorders. PMID:33425221
Mechanistic Modeling of Gene Regulation and Metabolism Identifies Potential Targets for Hepatocellular Carcinoma. PMID:33424926
Comparative Analysis of Dorsal Root, Nodose and Sympathetic Ganglia for the Development of New Analgesics. PMID:33424545
An "expressionistic" look at serrated precancerous colorectal lesions. PMID:33423702
Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum. PMID:33419470
TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway. PMID:33419081
Patient-Derived Organotypic Epithelial Rafts Model Phenotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis. PMID:33418959
KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway. PMID:33416175
Improved secretion of recombinant human IL-25 in HEK293 cells using a signal peptide-pro-peptide domain derived from Trypsin-1. PMID:33415569
ACOX2 is a prognostic marker and impedes the progression of hepatocellular carcinoma via PPARα pathway. PMID:33414412
Differential and spatial expression meta-analysis of genes identified in genome-wide association studies of depression. PMID:33414381
Sex-dependent differences in the secretome of human endothelial cells. PMID:33413676
MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility. PMID:33408244
Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome. PMID:33406800
Circulating MicroRNAs in Relation to Esophageal Adenocarcinoma Diagnosis and Survival. PMID:33403483
Oncogenic and tumor suppressor function of MEIS and associated factors. PMID:33402862
Broad Auto-Reactive IgM Responses Are Common In Critically Ill COVID-19 Patients. PMID:33398261
Hereditary Hearing Impairment with Cutaneous Abnormalities. PMID:33396879
Identifying Personalized Metabolic Signatures in Breast Cancer. PMID:33396819
TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue. PMID:33396509
Loss of LIMCH1 predicts poor prognosis in patients with surgically resected Lung Adenocarcinoma: A study based on Immunohistochemical Analysis and Bioinformatics. PMID:33391414
Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma. PMID:33390805
Bioinformatics Analyses of Potential miRNA-mRNA Regulatory Axis in HBV-related Hepatocellular Carcinoma. PMID:33390802
Evaluation of Male Fertility-Associated Loci in a European Population of Patients with Severe Spermatogenic Impairment. PMID:33383876
Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure. PMID:33382739
Validation of CSN1S1 transcriptional expression, promoter methylation, and prognostic power in breast cancer using independent datasets. PMID:33381666
Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation. PMID:33381480
FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases. PMID:33381084
The Skin Interactome: A Holistic "Genome-Microbiome-Exposome" Approach to Understand and Modulate Skin Health and Aging. PMID:33380819
Protocol for the Bottom-Up Proteomic Analysis of Mouse Spleen. PMID:33377090
Secret3D Workflow for Secretome Analysis. PMID:33377056
Immunohistochemical Analysis of PGC-1α and ERRα Expression Reveals Their Clinical Significance in Human Ovarian Cancer. PMID:33376354
C-type Lectin CD209L/L-SIGN and CD209/DC-SIGN: Cell Adhesion Molecules Turned to Pathogen Recognition Receptors. PMID:33375175
Sorting Nexins in Protein Homeostasis. PMID:33374212
Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19. PMID:33373644
HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails. PMID:33372037
Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma. PMID:33365083
The Future of GDNF in Parkinson's Disease. PMID:33364933
Regulatory Roles of Tumor Necrosis Factor-α-Induced Protein 8 Like-Protein 2 in Inflammation, Immunity and Cancers: A Review. PMID:33364825
Malignancy and IFITM3: Friend or Foe? PMID:33364194
Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases. PMID:33363699
Severe Acute Respiratory Syndrome Coronavirus 2-Induced Neurological Complications. PMID:33363165
PD-L1 Is a Tumor Suppressor in Aggressive Endometrial Cancer Cells and Its Expression Is Regulated by miR-216a and lncRNA MEG3. PMID:33363153
Profiling of H3K27Ac Reveals the Influence of Asthma on the Epigenome of the Airway Epithelium. PMID:33362848
From miRNA Target Gene Network to miRNA Function: miR-375 Might Regulate Apoptosis and Actin Dynamics in the Heart Muscle via Rho-GTPases-Dependent Pathways. PMID:33352947
The Role of Connexin 43 in Lung Disease. PMID:33352732
The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells. PMID:33351855
Coronavirus genomes carry the signatures of their habitats. PMID:33351847
Biological characteristics of aging in human acute myeloid leukemia cells: the possible importance of aldehyde dehydrogenase, the cytoskeleton and altered transcriptional regulation. PMID:33349623
Tumors Widely Express Hundreds of Embryonic Germline Genes. PMID:33348709
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2. PMID:33344479
Smell and Taste in Severe CoViD-19: Self-Reported vs. Testing. PMID:33344476
Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer. PMID:33342045
Parameterization of Microsomal and Cytosolic Scaling Factors: Methodological and Biological Considerations for Scalar Derivation and Validation. PMID:33340340
Prognostic relevance of programmed cell death 1 ligand 2 (PDCD1LG2/PD-L2) in patients with advanced stage colon carcinoma treated with chemotherapy. PMID:33339860
The lncRNA Toolkit: Databases and In Silico Tools for lncRNA Analysis. PMID:33339309
GSK3α: An Important Paralog in Neurodegenerative Disorders and Cancer. PMID:33339170
Decreasing the Susceptibility of Malignant Cells to Infection Does Not Impact the Overall Efficacy of Myxoma Virus-Based Oncolytic Virotherapy. PMID:33335977
Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING? PMID:33335532
Functional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming. PMID:33330447
Increased NFATC4 Correlates With Poor Prognosis of AML Through Recruiting Regulatory T Cells. PMID:33329712
Identification of Interleukin-9 Producing Immune Cells in Endometrial Carcinoma and Establishment of a Prognostic Nomogram. PMID:33329510
Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System. PMID:33328896
IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates. PMID:33324675
Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms. PMID:33322668
Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction. PMID:33322162
Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2. PMID:33320095
Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling. PMID:33319173
Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. PMID:33318207
Expression of PAWR predicts prognosis of ovarian cancer. PMID:33317551
A bioinformatics analysis on the potential role of ACE2 in cardiac impairment of patients with coronavirus disease 2019. PMID:33313148
Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture. PMID:33304744
Mass Spectral Analysis of Synthetic Peptides: Implications in Proteomics. PMID:33304200
Rho-GTPase pathways may differentiate treatment response to TNF-alpha and IL-17A inhibitors in psoriatic arthritis. PMID:33303908
Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro. PMID:33303781
A Multi-Strategy Sequencing Workflow in Inherited Retinal Dystrophies: Routine Diagnosis, Addressing Unsolved Cases and Candidate Genes Identification. PMID:33302505
Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin. PMID:33300026
Genetic Diversity of the Noncoding Control Region of the Novel Human Polyomaviruses. PMID:33297530
Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease. PMID:33294859
A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury. PMID:33294858
Prognostic and Predictive Value of a 15 Transcription Factors (TFs) Panel for Hepatocellular Carcinoma. PMID:33293862
Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development. PMID:33292279
Assessing immune infiltration and the tumor microenvironment for the diagnosis and prognosis of sarcoma. PMID:33292275
Network and Evolutionary Analysis of Human Epigenetic Regulators to Unravel Disease Associations. PMID:33291839
Prospects for Using Expression Patterns of Paramyxovirus Receptors as Biomarkers for Oncolytic Virotherapy. PMID:33291506
Proteomic Study Identifies Glycolytic and Inflammation Pathways Involved in Recurrent Otitis Media. PMID:33291465
Proteomic signatures of 16 major types of human cancer reveal universal and cancer-type-specific proteins for the identification of potential therapeutic targets. PMID:33287876
The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma. PMID:33287763
Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring-An Inactive Enzyme with Intact Substrate Binding. PMID:33287293
Overexpression of TPX2 predicts poor clinical outcome and is associated with immune infiltration in hepatic cell cancer. PMID:33285774
Options for COVID-19 Entry into Pulmonary Cells. PMID:33283173
Effect of EGLN1 Genetic Polymorphisms on Hemoglobin Concentration in Andean Highlanders. PMID:33282944
Machine Learning Based Network Analysis Determined Clinically Relevant miRNAs in Breast Cancer. PMID:33281885
Expression of ATP/GTP Binding Protein 1 Has Prognostic Value for the Clinical Outcomes in Non-Small Cell Lung Carcinoma. PMID:33276627
Complex genetic dependencies among growth and neurological phenotypes in healthy children: Towards deciphering developmental mechanisms. PMID:33270668
The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer. PMID:33270085
A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation. PMID:33268789
Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types. PMID:33266506
Machine Learning Identifies Robust Matrisome Markers and Regulatory Mechanisms in Cancer. PMID:33266472
The ADAR Family in Amphioxus: RNA Editing and Conserved Orthologous Site Predictions. PMID:33265998
Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins. PMID:33263282
Acute appendicitis in four children with SARS-CoV-2 infection. PMID:33262930
Bioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium. PMID:33262348
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import. PMID:33262325
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study. PMID:33261667
Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium. PMID:33256374
The G-Protein Coupled Formyl Peptide Receptors and Their Role in the Progression of Digestive Tract Cancer. PMID:33251986
Identification of potential biomarkers for lung adenocarcinoma. PMID:33251353
Serum RNA Profiling in the 10-Years Period Prior to Diagnosis of Testicular Germ Cell Tumor. PMID:33251139
On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. PMID:33246953
Missense variants in the N-terminal domain of the A isoform of FHF2/FGF13 cause an X-linked developmental and epileptic encephalopathy. PMID:33245860
PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2). PMID:33245768
Molecular Basis of Cardiac and Vascular Injuries Associated With COVID-19. PMID:33240937
Multiple functions of TBCK protein in neurodevelopment disorders and tumors. PMID:33240423
Identifying transcriptomic correlates of histology using deep learning. PMID:33237966
COVID-19 endocrinopathy with hindsight from SARS. PMID:33236920
Review of COVID-19 and male genital tract. PMID:33236375
Proteomics analysis of serum small extracellular vesicles for the longitudinal study of a glioblastoma multiforme mouse model. PMID:33235327
Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network. PMID:33234678
SARS-CoV-2 attachment to host cells is possibly mediated via RGD-integrin interaction in a calcium-dependent manner and suggests pulmonary EDTA chelation therapy as a novel treatment for COVID 19. PMID:33232865
BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. PMID:33232675
Upregulation of KIF20A promotes tumor proliferation and invasion in renal clear cell carcinoma and is associated with adverse clinical outcome. PMID:33232285
PINA 3.0: mining cancer interactome. PMID:33231689
Downstream Neighbor of SON (DONSON) Expression Is Enhanced in Phenotypically Aggressive Prostate Cancers. PMID:33228112
The value of a metabolic reprogramming-related gene signature for pancreatic adenocarcinoma prognosis prediction. PMID:33226369
Obesity Represses CYP2R1, the Vitamin D 25-Hydroxylase, in the Liver and Extrahepatic Tissues. PMID:33210060
Expression and role of nuclear receptor-interacting protein 1 (NRIP1) in stomach adenocarcinoma. PMID:33209873
Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota. PMID:33208821
Altered Tissue and Plasma Levels of Fibroblast Activation Protein-α (FAP) in Renal Tumours. PMID:33207686
Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva. PMID:33207190
The IMEx coronavirus interactome: an evolving map of Coronaviridae-host molecular interactions. PMID:33206959
The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer. PMID:33205077
Urinary glycoproteins associated with aggressive prostate cancer. PMID:33204318
Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling. PMID:33203841
Targeting the renin-angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges. PMID:33203679
The 40bp Indel Polymorphism rs150550023 in the MDM2 Promoter is Associated with Intriguing Shifts in Gene Expression in the p53-MDM2 Regulatory Hub. PMID:33202864
Combined liver-kidney transplantation for rare diseases. PMID:33200012
Identification of a New QTL Region on Mouse Chromosome 1 Responsible for Male Hypofertility: Phenotype Characterization and Candidate Genes. PMID:33198087
The Pursuit of COVID-19 Biomarkers: Putting the Spotlight on ACE2 and TMPRSS2 Regulatory Sequences. PMID:33195331
Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery. PMID:33195264
Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment. PMID:33194695
Integration of Online Omics-Data Resources for Cancer Research. PMID:33193699
TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019. PMID:33193689
Theoretical and in silico Analyses Reveal MYC as a Dynamic Network Biomarker in Colon and Rectal Cancer. PMID:33193630
Identification of Prognostic Markers in Cholangiocarcinoma Using Altered DNA Methylation and Gene Expression Profiles. PMID:33193605
Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology. PMID:33191914
Prognostic roles of metabolic reprogramming-associated genes in patients with hepatocellular carcinoma. PMID:33188160
Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker. PMID:33187367
Systematic comparison and assessment of RNA-seq procedures for gene expression quantitative analysis. PMID:33184454
Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice. PMID:33184425
Role of miRNAs in Sigmoid Colon Cancer: A Search for Potential Biomarkers. PMID:33182525
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4. PMID:33182504
Influence of Lipoxygenase Inhibition on Glioblastoma Cell Biology. PMID:33182324
EZH2 is a negative prognostic biomarker associated with immunosuppression in hepatocellular carcinoma. PMID:33180829
Comprehensive mapping of the human cytokine gene regulatory network. PMID:33179750
Comprehensive bioinformatics analysis of the TP53 signaling pathway in Wilms' tumor. PMID:33178760
α2-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling. PMID:33178692
Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19. PMID:33177848
Targeting receptor complexes: a new dimension in drug discovery. PMID:33177699
Prognosis prediction model for conversion from mild cognitive impairment to Alzheimer's disease created by integrative analysis of multi-omics data. PMID:33172501
Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta. PMID:33171905
Enhanced Validation of Antibodies Enables the Discovery of Missing Proteins. PMID:33170010
Synergy of melanin and vitamin-D may play a fundamental role in preventing SARS-CoV-2 infections and halt COVID-19 by inactivating furin protease. PMID:33169107
Deciphering cell-cell interactions and communication from gene expression. PMID:33168968
COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics. PMID:33166390
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities. PMID:33164751
CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A. PMID:33163493
The role of transcription factor caudal-related homeobox transcription factor 2 in colorectal cancer. PMID:33163374
Discovery, validation and sequencing of urinary peptides for diagnosis of liver fibrosis-A multicentre study. PMID:33160210
Cardiac and Vascular α1-Adrenoceptors in Congestive Heart Failure: A Systematic Review. PMID:33158106
The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma. PMID:33154775
Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin. PMID:33154365
Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A. PMID:33152346
LINC00968 can inhibit the progression of lung adenocarcinoma through the miR-21-5p/SMAD7 signal axis. PMID:33147570
The Human Protein Atlas-Spatial localization of the human proteome in health and disease. PMID:33146890
Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment. PMID:33146700
Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype. PMID:33142937
BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling. PMID:33142801
Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage. PMID:33140861
Functional module detection through integration of single-cell RNA sequencing data with protein-protein interaction networks. PMID:33138772
Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations. PMID:33138277
The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits. PMID:33137877
On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins. PMID:33136379
Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa. PMID:33133517
A Transcriptomics-Based Meta-Analysis Combined With Machine Learning Identifies a Secretory Biomarker Panel for Diagnosis of Pancreatic Adenocarcinoma. PMID:33133160
Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models. PMID:33131247
Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19. PMID:33123533
Prognosis Analysis and Validation of m6A Signature and Tumor Immune Microenvironment in Glioma. PMID:33123464
SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer. PMID:33122723
Screening and identification of key genes and pathways in metastatic uveal melanoma based on gene expression using bioinformatic analysis. PMID:33120861
Increased E2F2 predicts poor prognosis in patients with HCC based on TCGA data. PMID:33115417
Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma. PMID:33114768
CCL18 in the Progression of Cancer. PMID:33114763
The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease. PMID:33114658
Highly Multiplexed Single-Cell In Situ RNA and DNA Analysis by Consecutive Hybridization. PMID:33113917
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2. PMID:33112891
Genetic predisposition to neural crest-derived tumors: revisiting the role of KIF1B. PMID:33112832
An integrated autophagy-related gene signature predicts prognosis in human endometrial Cancer. PMID:33109128
O-Pair Search with MetaMorpheus for O-glycopeptide characterization. PMID:33106676
Three-gene prognostic biomarkers for seminoma identified by weighted gene co-expression network analysis. PMID:33104706
Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma. PMID:33103995
Protein-driven mechanism of multiorgan damage in COVID-19. PMID:33103107
Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis. PMID:33102693
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition. PMID:33101674
Whole Genome Sequence Data Provides Novel Insights Into the Genetic Architecture of Meat Quality Traits in Beef. PMID:33101375
Genome-Wide Co-Expression Distributions as a Metric to Prioritize Genes of Functional Importance. PMID:33092259
Neurobiological origins of individual differences in mathematical ability. PMID:33090992
Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers. PMID:33087697
Differential gene regulatory pattern in the human brain from schizophrenia using transcriptomic-causal network. PMID:33087039
The COVID-19 Pandemic from a Human Genetic Perspective. PMID:33084340
Improved detection of tumor suppressor events in single-cell RNA-Seq data. PMID:33083012
Base editing: advances and therapeutic opportunities. PMID:33077937
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands. PMID:33076281
Understand variability of COVID-19 through population and tissue variations in expression of SARS-CoV-2 host genes. PMID:33072849
Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney. PMID:33072769
ABC Exporters in Pathogenesis: Role of Synthetic Anti-Microbial Peptides. PMID:33068233
A high-stringency blueprint of the human proteome. PMID:33067450
Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patients. PMID:33061814
Use of patient derived urine renal epithelial cells to confirm pathogenicity of PKHD1 alleles. PMID:33059616
Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours? PMID:33057948
Application of small molecule FPR1 antagonists in the treatment of cancers. PMID:33057069
Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies. PMID:33053333
Protein-protein and protein-nucleic acid binding residues important for common and rare sequence variants in human. PMID:33050876
p38 MAPK Pathway in the Heart: New Insights in Health and Disease. PMID:33049962
CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia. PMID:33046866
INTEDE: interactome of drug-metabolizing enzymes. PMID:33045737
SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidney disease. PMID:33038424
ATP-Binding and Hydrolysis in Inflammasome Activation. PMID:33036374
Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes in vitro. PMID:33034335
PRELP has prognostic value and regulates cell proliferation and migration in hepatocellular carcinoma. PMID:33033521
Tissue distributions of antiviral drugs affect their capabilities of reducing viral loads in COVID-19 treatment. PMID:33031797
Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer. PMID:33030783
Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age. PMID:33029858
Cholesterol-Induced Phenotypic Modulation of Smooth Muscle Cells to Macrophage/Fibroblast-like Cells Is Driven by an Unfolded Protein Response. PMID:33028096
Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis. PMID:33025553
Computational assessment of MCM2 transcriptional expression and identification of the prognostic biomarker for human breast cancer. PMID:33024849
A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer. PMID:33024794
Benchmarking evolutionary tinkering underlying human-viral molecular mimicry shows multiple host pulmonary-arterial peptides mimicked by SARS-CoV-2. PMID:33024578
The Glycoprotease CpaA Secreted by Medically Relevant Acinetobacter Species Targets Multiple O-Linked Host Glycoproteins. PMID:33024038
Modeling tissue-relevant Caenorhabditis elegans metabolism at network, pathway, reaction, and metabolite levels. PMID:33022146
An analysis of tissue-specific alternative splicing at the protein level. PMID:33017396
G-Quadruplex Helicase DHX36/G4R1 Engages Nuclear Lamina Proteins in Quiescent Breast Cancer Cells. PMID:33015511
Comprehensive Analysis of the Expression, Relationship to Immune Infiltration and Prognosis of TIM-1 in Cancer. PMID:33014768
COVID-19: Proposing a Ketone-Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm. PMID:33014275
Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases. PMID:33014146
Identification of a Novel Immune-Related Prognostic Biomarker and Small-Molecule Drugs in Clear Cell Renal Cell Carcinoma (ccRCC) by a Merged Microarray-Acquired Dataset and TCGA Database. PMID:33014010
Causal Effects of Genetically Determined Metabolites on Risk of Polycystic Ovary Syndrome: A Mendelian Randomization Study. PMID:33013699
Functions of p38 MAP Kinases in the Central Nervous System. PMID:33013322
Prognostic Score-based Clinical Factors and Metabolism-related Biomarkers for Predicting the Progression of Hepatocellular Carcinoma. PMID:33013158
COVID-19 and multiorgan failure: A narrative review on potential mechanisms. PMID:33011887
Identification of prognostic biomarkers and correlations with immune infiltrates among cGAS-STING in hepatocellular carcinoma. PMID:33006365
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. PMID:33004675
The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process. PMID:33003328
Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19. PMID:33000221
High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner. PMID:32999402
Renin Angiotensin System, COVID-19 and Male Fertility: Any Risk for Conceiving? PMID:32998451
Stable gene expression for normalisation and single-sample scoring. PMID:32997146
The authors reply: Comment on "The expression landscape of cachexia-inducing factors in human cancers" by Freire et al. PMID:32996709
Extracellular vesicles in patients in the acute phase of psychosis and after clinical improvement: an explorative study. PMID:32995075
Selenium and selenoproteins in viral infection with potential relevance to COVID-19. PMID:32992282
The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion. PMID:32989016
8p11.23 Amplification in Breast Cancer: Molecular Characteristics, Prognosis and Targeted Therapy. PMID:32987805
Expanded Chinese hamster organ and cell line proteomics profiling reveals tissue-specific functionalities. PMID:32985598
Cell-Type-Specific Proteogenomic Signal Diffusion for Integrating Multi-Omics Data Predicts Novel Schizophrenia Risk Genes. PMID:32984858
The spectrum of biochemical alterations associated with organ dysfunction and inflammatory status and their association with disease outcomes in severe COVID-19: A longitudinal cohort and time-series design study. PMID:32984786
Quantitative systems pharmacology and the personalized drug-microbiota-diet axis. PMID:32984662
The Construction of Bone Metastasis-Specific Prognostic Model and Co-expressed Network of Alternative Splicing in Breast Cancer. PMID:32984314
Identification of Clinically Significant Prostate Cancer by Combined PCA3 and AMACR mRNA Detection in Urine Samples. PMID:32984088
Complement C7 (C7), a Potential Tumor Suppressor, Is an Immune-Related Prognostic Biomarker in Prostate Cancer (PC). PMID:32984006
Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques. PMID:32979349
Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease. PMID:32978267
Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries. PMID:32973800
Comprehensive analysis on the expression levels and prognostic values of LOX family genes in kidney renal clear cell carcinoma. PMID:32970930
Bioinformatics analysis and experimental validation of TTK as a biomarker for prognosis in non-small cell lung cancer. PMID:32969465
Identification of diagnostic and prognostic biomarkers, and candidate targeted agents for hepatitis B virus-associated early stage hepatocellular carcinoma based on RNA-sequencing data. PMID:32968453
T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration. PMID:32968060
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19. PMID:32966765
BCAS2, a protein enriched in advanced prostate cancer, interacts with NBS1 to enhance DNA double-strand break repair. PMID:32963349
Hypoketotic hypoglycemia in citrin deficiency: a case report. PMID:32962675
Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines. PMID:32961074
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency. PMID:32960813
In the blood: biomarkers for amyloid pathology and neurodegeneration in Alzheimer's disease. PMID:32954304
Designing custom CRISPR libraries for hypothesis-driven drug target discovery. PMID:32952937
Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption. PMID:32947816
Genetic Polymorphisms in Multispecific Transporters Mitigate Mercury Nephrotoxicity in an Artisanal and Small-Scale Gold Mining Community in Colombia. PMID:32946573
PAWER: protein array web exploreR. PMID:32942983
UPLC-qTOF-MS Phytochemical Profile and Antiulcer Potential of Cyperus conglomeratus Rottb. Alcoholic Extract. PMID:32942704
Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate. PMID:32939018
Breaking Bottlenecks for the TCR Therapy of Cancer. PMID:32937956
Using Deep Learning to Extrapolate Protein Expression Measurements. PMID:32937025
Consistency and variation of protein subcellular location annotations. PMID:32935893
Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin's lymphoma to many other types of solid cancers. PMID:32934776
TMEM206 is a potential prognostic marker of hepatocellular carcinoma. PMID:32934741
Prognostic effects of the expression of inhibitor of DNA-binding family members on patients with lung adenocarcinoma. PMID:32934711
Effects of the Delta Opioid Receptor Agonist DADLE in a Novel Hypoxia-Reoxygenation Model on Human and Rat-Engineered Heart Tissue: A Pilot Study. PMID:32932811
Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism. PMID:32927708
Prospective evaluation of the lymph node proteome in dogs with multicentric lymphoma supplemented with sulforaphane. PMID:32926463
Pinpointing Cell Identity in Time and Space. PMID:32923457
Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models. PMID:32923168
The Landscape of CAR-T Cell Clinical Trials against Solid Tumors-A Comprehensive Overview. PMID:32916883
Proteome-wide Changes in the mdx-4cv Spleen due to Pathophysiological Cross Talk with Dystrophin-Deficient Skeletal Muscle. PMID:32916630
A Quantitative Proteome Map of the Human Body. PMID:32916130
SLC25A51 is a mammalian mitochondrial NAD+ transporter. PMID:32906142
SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation. PMID:32905556
Regulation of the mitochondrial permeability transition pore and its effects on aging. PMID:32904375
CAR T Cell Therapy for Pediatric Brain Tumors. PMID:32903405
Integration of molecular profiles in a longitudinal wellness profiling cohort. PMID:32900998
Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton's Jelly-Derived Mesenchymal Stem Cells. PMID:32899389
Age-related copy number variations and expression levels of F-box protein FBXL20 predict ovarian cancer prognosis. PMID:32898767
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases. PMID:32895551
Targeting UDP-glucose dehydrogenase inhibits ovarian cancer growth and metastasis. PMID:32893977
Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain. PMID:32887883
Lipid Phosphate Phosphatases and Cancer. PMID:32887262
Genome-wide association study for circulating fibroblast growth factor 21 and 23. PMID:32884031
EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data. PMID:32883324
Thioredoxin-Related Transmembrane Proteins: TMX1 and Little Brothers TMX2, TMX3, TMX4 and TMX5. PMID:32878123
Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling. PMID:32876046
Fractional diffusion on the human proteome as an alternative to the multi-organ damage of SARS-CoV-2. PMID:32872802
Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. PMID:32867764
Plasma protein-based signature predicts distant metastasis and induction chemotherapy benefit in Nasopharyngeal Carcinoma. PMID:32863958
Central neurological complications and potential neuropathogenesis of COVID-19. PMID:32860569
microRNAs and Corresponding Targets Involved in Metastasis of Colorectal Cancer in Preclinical In Vivo Models. PMID:32859626
Genetically raised serum bilirubin levels and lung cancer: a cohort study and Mendelian randomisation using UK Biobank. PMID:32855344
Novel insights into the disease transcriptome of human diabetic glomeruli and tubulointerstitium. PMID:32853351
Learning the properties of adaptive regions with functional data analysis. PMID:32853200
Cellular diversity of the regenerating caudal fin. PMID:32851162
A Quantitative Analysis of Cellular Lipid Compositions During Acute Proteotoxic ER Stress Reveals Specificity in the Production of Asymmetric Lipids. PMID:32850859
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Colon Adenocarcinoma Metastasis. PMID:32850813
Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection. PMID:32850483
LC3-Associated Phagocytosis (LAP): A Potentially Influential Mediator of Efferocytosis-Related Tumor Progression and Aggressiveness. PMID:32850405
Low Expression of Claudin-7 as Potential Predictor of Distant Metastases in High-Grade Serous Ovarian Carcinoma Patients. PMID:32850397
Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells. PMID:32850342
Leveraging Public Single-Cell and Bulk Transcriptomic Datasets to Delineate MAIT Cell Roles and Phenotypic Characteristics in Human Malignancies. PMID:32849590
The Endosomal Recycling Pathway-At the Crossroads of the Cell. PMID:32842549
DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas. PMID:32838940
Clustering analysis of tumor metabolic networks. PMID:32838750
Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. PMID:32838361
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. PMID:32832599
The intermembrane space protein Mix23 is a novel stress-induced mitochondrial import factor. PMID:32826315
Proteomic Analysis of Exosomes for Discovery of Protein Biomarkers for Prostate and Bladder Cancer. PMID:32825017
Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells. PMID:32823874
A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions. PMID:32822567
SRSF1 regulates exosome microRNA enrichment in human cancer cells. PMID:32819370
Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris. PMID:32817591
Multiomic blood correlates of genetic risk identify presymptomatic disease alterations. PMID:32817414
Tracking the carbons supplying gluconeogenesis. PMID:32817317
Favorable therapeutic response after anti-Mesothelin antibody-drug conjugate treatment requires high expression of Mesothelin in tumor cells. PMID:32815024
Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt. PMID:32814826
Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets. PMID:32814578
The mitochondrial transcription machinery genes are upregulated in acute myeloid leukemia and associated with poor clinical outcome. PMID:32812906
Enzymatic Noncovalent Synthesis. PMID:32812754
Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation. PMID:32812257
Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis? PMID:32811540
GFAP at 50. PMID:32811163
The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer. PMID:32802887
Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks. PMID:32796035
The methylation status of the chemerin promoter region located from - 252 to + 258 bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels. PMID:32792625
SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule. PMID:32791255
Combining Gene-Disease Associations with Single-Cell Gene Expression Data Provides Anatomy-Specific Subnetworks in Age-Related Macular Degeneration. PMID:32789304
The prognostic value of HGF-c-MET signaling pathway in Gastric Cancer: a study based on TCGA and GEO databases. PMID:32788873
Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane. PMID:32788342
Snca-GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding. PMID:32788297
COVID-19 and comorbidities: Deleterious impact on infected patients. PMID:32788073
Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility. PMID:32785227
C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients with Gestational Diabetes Mellitus: A Case-Control Study. PMID:32785102
Expression and clinical significance of methyl-CpG binding domain protein 2 in high-grade serous ovarian cancer. PMID:32782591
Identification of a five-gene signature for predicting the progression and prognosis of stage I endometrial carcinoma. PMID:32782557
Characterization of the different oligomeric states of the DAN family antagonists SOSTDC1 and SOST. PMID:32779697
Building the vertebrate codex using the gene breaking protein trap library. PMID:32779569
Presence of SARS-Coronavirus-2 in the Ileal Mucosa: Another Evidence for Infection of GI Tract by This Virus. PMID:32777284
Gene expression of the IGF hormones and IGF binding proteins across time and tissues in a model reptile. PMID:32776803
FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease. PMID:32776417
Expression of smooth muscle-like effectors and core cardiomyocyte regulators in the contractile papillae of Ciona. PMID:32774829
Discovery and validation of surface N-glycoproteins in MM cell lines and patient samples uncovers immunotherapy targets. PMID:32771993
TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion. PMID:32767843
Identification of the association between HMMR expression and progression of hepatocellular carcinoma via construction of a co-expression network. PMID:32765791
Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice. PMID:32764719
Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence. PMID:32764696
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front. PMID:32763154
Genome-wide methylation patterns predict clinical benefit of immunotherapy in lung cancer. PMID:32762727
Association of WNT7B and RSPO1 with Axial Length in School Children. PMID:32761137
Systems Biology Will Direct Vascular-Targeted Therapy for Obesity. PMID:32760294
Abnormal expression and prognostic significance of EPB41L1 in kidney renal clear cell carcinoma based on data mining. PMID:32760223
Bioinformatic Analysis of Correlation between Immune Infiltration and COVID-19 in Cancer Patients. PMID:32760213
Collagen Type III Alpha 1 chain regulated by GATA-Binding Protein 6 affects Type II IFN response and propanoate metabolism in the recurrence of lower grade glioma. PMID:32757451
Cerebral Immunohistochemical Characterization of the H2S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma. PMID:32754111
IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion. PMID:32753652
The Clinicopathological and Prognostic Significance of Nrf2 and Keap1 Expression in Hepatocellular Carcinoma. PMID:32751896
Integrative Omics Analyses Reveal Epigenetic Memory in Diabetic Renal Cells Regulating Genes Associated With Kidney Dysfunction. PMID:32747424
ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair. PMID:32744506
Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. PMID:32737331
Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer. PMID:32737302
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality. PMID:32737166
Molecular profiling of immune cell-enriched Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) interacting protein USP13. PMID:32735883
Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA. PMID:32735619
The Link Between the Mitochondrial Fatty Acid Oxidation Derangement and Kidney Injury. PMID:32733282
Systems Biology Approaches to Understand the Host-Microbiome Interactions in Neurodegenerative Diseases. PMID:32733199
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine. PMID:32730777
The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics. PMID:32728795
Occupancy maps of 208 chromatin-associated proteins in one human cell type. PMID:32728244
Lysosome-targeting chimaeras for degradation of extracellular proteins. PMID:32728216
Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer. PMID:32728173
Pyk2 Regulates Human Papillomavirus Replication by Tyrosine Phosphorylation of the E2 Protein. PMID:32727877
CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma. PMID:32727598
Multiple formin proteins participate in glioblastoma migration. PMID:32727404
The Interplay of Tumor Stroma and Translational Factors in Endometrial Cancer. PMID:32726992
Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer. PMID:32726752
Breed Differences in Dog Cognition Associated with Brain-Expressed Genes and Neurological Functions. PMID:32726413
In silico identification of the prognostic biomarkers and therapeutic targets associated with cancer stem cell characteristics of glioma. PMID:32725165
Mining the prognostic significance of the GINS2 gene in human breast cancer using bioinformatics analysis. PMID:32724372
Tumor Necrosis Factor Receptor SF10A (TNFRSF10A) SNPs Correlate With Corticosteroid Response in Duchenne Muscular Dystrophy. PMID:32719714
Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model. PMID:32719544
Insights into the skin of caecilian amphibians from gene expression profiles. PMID:32718305
Piggybacking on Classical Import and Other Non-Classical Mechanisms of Nuclear Import Appear Highly Prevalent within the Human Proteome. PMID:32718019
The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis. PMID:32717840
The protein expression profile of ACE2 in human tissues. PMID:32715618
Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease. PMID:32714578
Conventional protein kinase C in the brain: 40 years later. PMID:32714576
Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer's disease. PMID:32711556
Guarding the Genome: CENP-A-Chromatin in Health and Cancer. PMID:32708729
Chemokine Receptors CCR1 and CCR2 on Peripheral Blood Mononuclear Cells of Newly Diagnosed Patients with the CD38-Positive Chronic Lymphocytic Leukemia. PMID:32708233
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma. PMID:32707078
Downregulation of miR‑193a‑3p via targeting cyclin D1 in thyroid cancer. PMID:32705210
Transcriptomic comparison of human and mouse brain microvessels. PMID:32704093
Megalin/lipoprotein receptor-related protein 2 autoimmunity and kidney disease. PMID:32701075
Promoting crystallization of intrinsic membrane proteins with conjugated micelles. PMID:32699228
Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease. PMID:32696702
Analysis of m6A RNA methylation in Caenorhabditis elegans. PMID:32695436
Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours. PMID:32694827
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. PMID:32694731
FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation. PMID:32694203
Cellular Imprinting Proteomics Assay: A Novel Method for Detection of Neural and Ocular Disorders Applied to Congenital Zika Virus Syndrome. PMID:32686424
MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling. PMID:32681036
ECRG2, a novel transcriptional target of p53, modulates cancer cell sensitivity to DNA damage. PMID:32681017
Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines. PMID:32680547
Gene expression profiling identifies the role of Zac1 in cervical cancer metastasis. PMID:32678267
Secreted Frizzled-Related Protein 4 (SFRP4) Is an Independent Prognostic Marker in Prostate Cancers Lacking TMPRSS2: ERG Fusions. PMID:32677026
The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction. PMID:32670277
Brainstem Organoids From Human Pluripotent Stem Cells. PMID:32670003
A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells. PMID:32669955
Estimation of Hub Genes and Infiltrating Immune Cells in Non-Smoking Females with Lung Adenocarcinoma by Integrated Bioinformatic Analysis. PMID:32669531
Indication of Premelanosome Protein (PMEL) Expression Outside of Pigmented Bovine Skin Suggests Functions Beyond Eumelanogenesis. PMID:32668786
Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation. PMID:32667968
SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis. PMID:32664949
Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells. PMID:32664515
HRT Atlas v1.0 database: redefining human and mouse housekeeping genes and candidate reference transcripts by mining massive RNA-seq datasets. PMID:32663312
Metabolic Messengers: Adiponectin. PMID:32661510
New Insights on Genetic Diagnostics in Cardiomyopathy and Arrhythmia Patients Gained by Stepwise Exome Data Analysis. PMID:32659924
Chromatin network markers of leukemia. PMID:32657405
Abl1 deletion in gut stem cells suppresses p53 induction and promotes colitis-associated tumor formation. PMID:32652042
Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury. PMID:32651223
Quantitative characterization of tumor cell-free DNA shortening. PMID:32650715
Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins. PMID:32647060
Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome. PMID:32645919
Serine Incorporator 2 (SERINC2) Expression Predicts an Unfavorable Prognosis of Low-Grade Glioma (LGG): Evidence from Bioinformatics Analysis. PMID:32642801
CRISPR-based functional genomics for neurological disease. PMID:32641861
SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle. PMID:32641214
Clinical validation of the novel HDAC6 radiotracer [18F]EKZ-001 in the human brain. PMID:32638097
A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic. PMID:32637960
Systematic analysis reveals a functional role for STAMBPL1 in the epithelial-mesenchymal transition process across multiple carcinomas. PMID:32636467
Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury. PMID:32636391
Lipid Signaling in Ocular Neovascularization. PMID:32635437
Identification of miRNA Master Regulators in Breast Cancer. PMID:32635183
HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia. PMID:32634239
Variance-adjusted Mahalanobis (VAM): a fast and accurate method for cell-specific gene set scoring. PMID:32633778
Muscle-derived Myoglianin regulates Drosophila imaginal disc growth. PMID:32633716
Mitoribosome Defect in Hepatocellular Carcinoma Promotes an Aggressive Phenotype with Suppressed Immune Reaction. PMID:32629612
Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling. PMID:32629387
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections. PMID:32628701
Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits. PMID:32628676
Long-term ACE Inhibitor/ARB Use Is Associated With Severe Renal Dysfunction and Acute Kidney Injury in Patients With Severe COVID-19: Results From a Referral Center Cohort in the Northeast of France. PMID:32623470
A brief review of liver injury in patients with Corona Virus Disease-19 during the pandemic. PMID:32621206
Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome. PMID:32619492
The transcriptional signature associated with human motile cilia. PMID:32616903
ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins. PMID:32616830
Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies. PMID:32612606
Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular Pathology. PMID:32612540
Physiological blood-brain transport is impaired with age by a shift in transcytosis. PMID:32612231
Inhibition of Bruton's TK regulates macrophage NF-κB and NLRP3 inflammasome activation in metabolic inflammation. PMID:32608058
Candidate protein biomarkers in pancreatic neuroendocrine neoplasms grade 3. PMID:32606315
The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells. PMID:32603710
Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection. PMID:32602627
Proximity Ligation Assay as a Tool for Antibody Validation in Human Tissues. PMID:32602410
Profiling tear proteomes of patients with unilateral relapsed Behcet's disease-associated uveitis using data-independent acquisition proteomics. PMID:32596040
Analysis of Expression and Its Clinical Significance of the Secreted Phosphoprotein 1 in Lung Adenocarcinoma. PMID:32595698
High prevalence of plasma lipid abnormalities in human and canine Duchenne and Becker muscular dystrophies depicts a new type of primary genetic dyslipidemia. PMID:32593511
Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice†. PMID:32588889
DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer. PMID:32588770
The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions. PMID:32587962
Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development. PMID:32587777
COVID-19 pandemic: Its impact on liver disease and liver transplantation. PMID:32587443
Identification of Cell-Surface Proteins Endocytosed by Human Brain Microvascular Endothelial Cells In Vitro. PMID:32585920
Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters. PMID:32582958
cfNOMe - A single assay for comprehensive epigenetic analyses of cell-free DNA. PMID:32580754
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma. PMID:32579974
Profiling the circulating mRNA transcriptome in human liver disease. PMID:32577166
Regulation of cellular senescence by eukaryotic members of the FAH superfamily - A role in calcium homeostasis? PMID:32574647
The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence-associated epigenomic remodeling. PMID:32573059
Matriptase processing of APLP1 ectodomain alters its homodimerization. PMID:32572095
Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury. PMID:32571916
Conserved Small Nucleotidic Elements at the Origin of Concerted piRNA Biogenesis from Genes and lncRNAs. PMID:32570966
Identification of a Robust Five-Gene Risk Model in Prostate Cancer: A Robust Likelihood-Based Survival Analysis. PMID:32566639
A Sample Preparation Protocol for High Throughput Immunofluorescence of Suspension Cells on an Adherent Surface. PMID:32564662
Evidence for endothelial-to-mesenchymal transition in human brain arteriovenous malformations. PMID:32564509
Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis. PMID:32561683
Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn's Disease. PMID:32561494
Mapping of CaM, S100A1 and PIP2-Binding Epitopes in the Intracellular N- and C-Termini of TRPM4. PMID:32560560
Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target. PMID:32560530
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. PMID:32559194
Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2. PMID:32558639
GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma. PMID:32555306
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. PMID:32554929
HDAC9 deficiency promotes tumor progression by decreasing the CD8+ dendritic cell infiltration of the tumor microenvironment. PMID:32554611
LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome. PMID:32553112
Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells. PMID:32552827
The effect of age on the microarchitecture and profile of gene expression in femoral head and neck bone from patients with osteoarthritis. PMID:32551338
Tissue-Specific Requirement for the GINS Complex During Zebrafish Development. PMID:32548116
Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor. PMID:32546533
The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly. PMID:32542055
Unveiling prognostics biomarkers of tyrosine metabolism reprogramming in liver cancer by cross-platform gene expression analyses. PMID:32542016
Dynamic rewiring of the human interactome by interferon signaling. PMID:32539747
Integrated Analyses Identify Immune-Related Signature Associated with Qingyihuaji Formula for Treatment of Pancreatic Ductal Adenocarcinoma Using Network Pharmacology and Weighted Gene Co-Expression Network. PMID:32537471
Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance. PMID:32536688
Why Great Mitotic Inhibitors Make Poor Cancer Drugs. PMID:32536592
PET Imaging of the Natural Killer Cell Activation Receptor NKp30. PMID:32532927
Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways. PMID:32526885
GOcats: A tool for categorizing Gene Ontology into subgraphs of user-defined concepts. PMID:32525872
Systematic Humanization of the Yeast Cytoskeleton Discerns Functionally Replaceable from Divergent Human Genes. PMID:32522745
Comprehensive analysis reveals a metabolic ten-gene signature in hepatocellular carcinoma. PMID:32518728
Severe chronic kidney disease environment reduced calcium-sensing receptor expression in parathyroid glands of adenine-induced rats even without high phosphorus diet. PMID:32517664
A framework for integrating directed and undirected annotations to build explanatory models of cis-eQTL data. PMID:32516306
Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice. PMID:32516134
The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer. PMID:32515734
Downexpression of HSD17B6 correlates with clinical prognosis and tumor immune infiltrates in hepatocellular carcinoma. PMID:32514254
SARS-CoV-2 receptor networks in diabetic kidney disease, BK-Virus nephropathy and COVID-19 associated acute kidney injury. PMID:32511461
Overexpressed gene signature of EPH receptor A/B family in cancer patients-comprehensive analyses from the public high-throughput database. PMID:32509099
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint. PMID:32508832
Tetraspanins in the regulation of mast cell function. PMID:32507938
Hepatic consequences of COVID-19 infection. Lapping or biting? PMID:32507608
Analysis of human metabolism by reducing the complexity of the genome-scale models using redHUMAN. PMID:32499584
Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned so Far. PMID:32498343
Tox21BodyMap: a webtool to map chemical effects on the human body. PMID:32491175
Decoding the Body Language of Immunity: Tackling the Immune System at the Organism Level. PMID:32490290
Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. PMID:32487735
Significance of STAT3 in Immune Infiltration and Drug Response in Cancer. PMID:32486001
Emerging Roles of Gemin5: From snRNPs Assembly to Translation Control. PMID:32485878
Age-Related Changes in Hair Shaft Protein Profiling and Genetically Variant Peptides. PMID:32485593
TRPM4 is overexpressed in breast cancer associated with estrogen response and epithelial-mesenchymal transition gene sets. PMID:32484822
The role of 3'UTR-protein complexes in the regulation of protein multifunctionality and subcellular localization. PMID:32484544
Partial proteolysis improves the identification of the extracellular segments of transmembrane proteins by surface biotinylation. PMID:32483232
Integrated omics in Drosophila uncover a circadian kinome. PMID:32483184
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor. PMID:32483149
Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation. PMID:32482897
Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia. PMID:32481505
Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens. PMID:32477965
Cardiac involvement in a cross-sectional cohort of myotonic dystrophies and other skeletal myopathies. PMID:32476276
Annexin A1 is a Potential Novel Biomarker of Congestion in Acute Heart Failure. PMID:32473378
Buccal Mucosa Biomarkers in Alzheimer's Disease. PMID:32468458
Endometrial profilin 1: a key player in embryo-endometrial crosstalk. PMID:32466630
Personalized whole-body models integrate metabolism, physiology, and the gut microbiome. PMID:32463598
Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors. PMID:32463365
Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases. PMID:32462403
Flexible Mixture Model Approaches That Accommodate Footprint Size Variability for Robust Detection of Balancing Selection. PMID:32462188
AKNA Is a Potential Prognostic Biomarker in Gastric Cancer and Function as a Tumor Suppressor by Modulating EMT-Related Pathways. PMID:32462010
Quantitative analysis of Y-Chromosome gene expression across 36 human tissues. PMID:32461223
Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma. PMID:32460791
Integration of Heterogeneous Experimental Data Improves Global Map of Human Protein Complexes. PMID:32457940
A Bitter Taste in Your Heart. PMID:32457649
The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target? PMID:32457627
Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding. PMID:32457219
The Role of Selected Chemokines and Their Receptors in the Development of Gliomas. PMID:32456359
MicrobioLink: An Integrated Computational Pipeline to Infer Functional Effects of Microbiome-Host Interactions. PMID:32455748
A bidirectional Mendelian randomization study supports causal effects of kidney function on blood pressure. PMID:32454124
Chemerin as a Driver of Hypertension: A Consideration. PMID:32453820
PseudoChecker: an integrated online platform for gene inactivation inference. PMID:32449938
Gene X environment: the cellular environment governs the transcriptional response to environmental chemicals. PMID:32448403
Glycoprotein nonmetastatic melanoma protein B: A key mediator and an emerging therapeutic target in autoimmune diseases. PMID:32445534
TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling. PMID:32444641
Human genetic dissection of papillomavirus-driven diseases: new insight into their pathogenesis. PMID:32435828
The CD47-SIRPα Immune Checkpoint. PMID:32433947
Genetic Determinants of Reduced Arsenic Metabolism Efficiency in the 10q24.32 Region Are Associated With Reduced AS3MT Expression in Multiple Human Tissue Types. PMID:32433756
Comprehensive analysis of the value of RAB family genes in prognosis of breast invasive carcinoma. PMID:32432324
Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability. PMID:32429325
Anti-vimentin, anti-TUFM, anti-NAP1L1 and anti-DPYSL2 nanobodies display cytotoxic effect and reduce glioblastoma cell migration. PMID:32426045
Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract. PMID:32425701
Secretome-Based Screening in Target Discovery. PMID:32425085
Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains. PMID:32424074
Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking. PMID:32423029
Rare Genetic Diseases: Nature's Experiments on Human Development. PMID:32422592
Progress, Challenges, and Surprises in Annotating the Human Genome. PMID:32421357
Machine Learning Supports Long Noncoding RNAs as Expression Markers for Endometrial Carcinoma. PMID:32420338
Ten-eleven translocation proteins and their role beyond DNA demethylation - what we can learn from the fly. PMID:32419604
A Fast and Memory-Efficient Spectral Library Search Algorithm Using Locality-Sensitive Hashing. PMID:32415809
Art and Science of the Cellular Mesoscale. PMID:32413324
Association between SNAP25 and human glioblastoma multiform: a comprehensive bioinformatic analysis. PMID:32412599
Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq. PMID:32410729
BAHD1 haploinsufficiency results in anxiety-like phenotypes in male mice. PMID:32407325
Identification of transforming growth factor beta induced (TGFBI) as an immune-related prognostic factor in clear cell renal cell carcinoma (ccRCC). PMID:32406866
Spatio-Temporal Roles of ASD-Associated Variants in Human Brain Development. PMID:32403330
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP. PMID:32402273
Urinary Extracellular Vesicles and Salt-Losing Tubulopathies: A Proteomic Approach. PMID:32397528
StanDep: Capturing transcriptomic variability improves context-specific metabolic models. PMID:32396573
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. PMID:32393898
The emerging roles of WBP2 oncogene in human cancers. PMID:32393834
Nucleoside Reverse Transcriptase Inhibitor Interaction with Human Equilibrative Nucleoside Transporters 1 and 2. PMID:32393653
Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors. PMID:32388565
Mantis-ml: Disease-Agnostic Gene Prioritization from High-Throughput Genomic Screens by Stochastic Semi-supervised Learning. PMID:32386536
Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes. PMID:32385057
Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. PMID:32382484
eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled. PMID:32381507
Identification and validation of the angiogenic genes for constructing diagnostic, prognostic, and recurrence models for hepatocellular carcinoma. PMID:32379058
Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation. PMID:32376919
Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 Adrenoceptors. PMID:32376421
Severe acute respiratory syndrome coronavirus 2 detection in the female lower genital tract. PMID:32376320
Integrative analyses of the RNA modification machinery reveal tissue- and cancer-specific signatures. PMID:32375858
MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth. PMID:32371956
A single-cell transcriptomic landscape of primate arterial aging. PMID:32371953
Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues. PMID:32371927
Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding. PMID:32369656
Towards the routine use of in silico screenings for drug discovery using metabolic modelling. PMID:32369553
Tryptophan catabolism reflects disease activity in human tuberculosis. PMID:32369456
Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation. PMID:32366865
TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. PMID:32366851
Proteomics illuminates fat as key tissue in aging. PMID:32366668
Cystathionine-β-Synthase: Molecular Regulation and Pharmacological Inhibition. PMID:32365821
Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche. PMID:32354994
Is SARS-CoV-2 Also an Enteric Pathogen With Potential Fecal-Oral Transmission? A COVID-19 Virological and Clinical Review. PMID:32353371
TRP Channels as Emerging Therapeutic Targets for Neurodegenerative Diseases. PMID:32351395
Whole transcriptome analysis and validation of metabolic pathways in subcutaneous adipose tissues during FGF21-induced weight loss in non-human primates. PMID:32350364
Hepatocyte nuclear factor-4α regulates expression of the serotonin transporter in intestinal epithelial cells. PMID:32348179
T cell costimulation, checkpoint inhibitors and anti-tumor therapy. PMID:32345776
Shared genetic architecture and casual relationship between leptin levels and type 2 diabetes: large-scale cross-trait meta-analysis and Mendelian randomization analysis. PMID:32341051
Urinary Exosomal MicroRNA Signatures in Nephrotic, Biopsy-Proven Diabetic Nephropathy. PMID:32340338
Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression. PMID:32338600
The Oncogenic Role of CENPA in Hepatocellular Carcinoma Development: Evidence from Bioinformatic Analysis. PMID:32337237
Identification of genes involved in the evolution of human intelligence through combination of inter-species and intra-species genetic variations. PMID:32337102
Expression of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in the Gut of Patients With IBD. PMID:32333601
MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer. PMID:32332866
Adsorption of a styrene maleic acid (SMA) copolymer-stabilized phospholipid nanodisc on a solid-supported planar lipid bilayer. PMID:32330753
Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3. PMID:32330444
Translational genomics for achieving higher genetic gains in groundnut. PMID:32328677
Genetic Roadmap for Kidney Involvement of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. PMID:32327413
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression. PMID:32326089
Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis. PMID:32325894
Tissue-selective regulation of protein homeostasis and unfolded protein response signalling in sporadic ALS. PMID:32324341
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer. PMID:32322170
Consistent RNA sequencing contamination in GTEx and other data sets. PMID:32321923
Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population. PMID:32321463
Risks of ACE Inhibitor and ARB Usage in COVID-19: Evaluating the Evidence. PMID:32320478
SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines. PMID:32319594
Direct trafficking pathways from the Golgi apparatus to the plasma membrane. PMID:32317144
Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4. PMID:32316263
PDZ Domains as Drug Targets. PMID:32313833
Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection. PMID:32311451
GDF15: A Hormone Conveying Somatic Distress to the Brain. PMID:32310257
Functional Amyloids and their Possible Influence on Alzheimer Disease. PMID:32309597
Ribosomal protein RACK1 enhances translation of poliovirus and other viral IRESs. PMID:32308198
ALS-associated genes in SCA2 mouse spinal cord transcriptomes. PMID:32307524
Histone Deacetylases in Kidney Physiology and Acute Kidney Injury. PMID:32303277
Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia. PMID:32302554
Nitrogen Metabolism in Cancer and Immunity. PMID:32302552
Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes. PMID:32302527
Plasma membrane expression of G protein-coupled estrogen receptor (GPER)/G protein-coupled receptor 30 (GPR30) is associated with worse outcome in metachronous contralateral breast cancer. PMID:32302351
Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice†. PMID:32301969
NCAPG Is a Promising Therapeutic Target Across Different Tumor Types. PMID:32300299
Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers. PMID:32298395
The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling. PMID:32296774
PTHrP, A Biomarker for CNS Metastasis in Triple-Negative Breast Cancer and Selection for Adjuvant Chemotherapy in Node-Negative Disease. PMID:32296756
Transcriptome analysis revealed key prognostic genes and microRNAs in hepatocellular carcinoma. PMID:32296612
A WIZ/Cohesin/CTCF Complex Anchors DNA Loops to Define Gene Expression and Cell Identity. PMID:32294452
Molecular effects of dADD1 misexpression in chromatin organization and transcription. PMID:32293240
Dysregulation of Type II Transmembrane Serine Proteases and Ligand-Dependent Activation of MET in Urological Cancers. PMID:32290402
Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort. PMID:32290310
Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome. PMID:32286305
Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine. PMID:32284825
Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease. PMID:32277752
Methionine Dependence of Cancer. PMID:32276408
Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis. PMID:32275865
Characteristics and Mechanism of Liver Injury in 2019 Coronavirus Disease. PMID:32274341
Differential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma. PMID:32273545
Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH. PMID:32271712
High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. PMID:32271093
Translational Control of Secretory Proteins in Health and Disease. PMID:32268488
Systems Biochemistry Approaches to Defining Mitochondrial Protein Function. PMID:32268114
DirectMX - One-Step Reconstitution of Membrane Proteins From Crude Cell Membranes Into Salipro Nanoparticles. PMID:32266242
Erosion of Gene Co-expression Networks Reveal Deregulation of Immune System Processes in Late-Onset Alzheimer's Disease. PMID:32265636
Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines. PMID:32265286
CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110. PMID:32264921
A Key mRNA-miRNA-lncRNA Competing Endogenous RNA Triple Sub-network Linked to Diagnosis and Prognosis of Hepatocellular Carcinoma. PMID:32257949
Low RAB6C expression is a predictor of tamoxifen benefit in estrogen receptor-positive/progesterone receptor-negative breast cancer. PMID:32257197
CCNB2, NUSAP1 and TK1 are associated with the prognosis and progression of hepatocellular carcinoma, as revealed by co-expression analysis. PMID:32256749
Nucleolin-Sle A Glycoforms as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer Cells. PMID:32252346
Pulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features. PMID:32251643
Discovery of a selective inhibitor of doublecortin like kinase 1. PMID:32251410
Urine Extracellular Vesicle GATA2 mRNA Discriminates Biopsy Result in Men with Suspicion of Prostate Cancer. PMID:32250729
Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside. PMID:32247663
Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles. PMID:32245988
Safety and Feasibility of PARP1/2 Imaging with 18F-PARPi in Patients with Head and Neck Cancer. PMID:32245901
Phosphoproteomic characterization of the signaling network resulting from activation of the chemokine receptor CCR2. PMID:32241914
Differential co-expression analysis reveals early stage transcriptomic decoupling in alzheimer's disease. PMID:32241275
Pseudogene-gene functional networks are prognostic of patient survival in breast cancer. PMID:32241256
Cell-type diversity and regionalized gene expression in the planarian intestine. PMID:32240093
Development and validation of a survival model for lung adenocarcinoma based on autophagy-associated genes. PMID:32238163
Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex. PMID:32235678
Multiomics Evaluation of Gastrointestinal and Other Clinical Characteristics of COVID-19. PMID:32234303
Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage. PMID:32229571
Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro. PMID:32228452
IL-4R is expressed on alpha and beta cells of human pancreata. PMID:32224156
Investigating LGALS3BP/90 K glycoprotein in the cerebrospinal fluid of patients with neurological diseases. PMID:32221402
Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer. PMID:32218990
Identification of hub genes associated with outcome of clear cell renal cell carcinoma. PMID:32218839
Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth. PMID:32218467
Heparan sulfate is a clearance receptor for aberrant extracellular proteins. PMID:32211892
Leucine Rich Repeat Kinase 2 and Innate Immunity. PMID:32210756
Cellular processes involved in lung cancer cells exposed to direct current electric field. PMID:32210363
Anatomy of a viral entry platform differentially functionalized by integrins α3 and α6. PMID:32210347
An atlas of human metabolism. PMID:32209698
The signal peptide as a new target for drug design. PMID:32209293
Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease. PMID:32208444
Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer. PMID:32207251
Mass Spectrometry Advances and Perspectives for the Characterization of Emerging Adoptive Cell Therapies. PMID:32204371
Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer. PMID:32201920
Tumor cell-organized fibronectin maintenance of a dormant breast cancer population. PMID:32195352
An array of 60,000 antibodies for proteome-scale antibody generation and target discovery. PMID:32195335
Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma. PMID:32194798
Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. PMID:32193359
5-Aza-2'-deoxycytidine advances the epithelial-mesenchymal transition of breast cancer cells by demethylating Sipa1 promoter-proximal elements. PMID:32193333
Brain manganese and the balance between essential roles and neurotoxicity. PMID:32188696
Discovery of non-HLA antibodies associated with cardiac allograft rejection and development and validation of a non-HLA antigen multiplex panel: From bench to bedside. PMID:32185871
Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress. PMID:32183456
An Overview on ERAP Roles in Infectious Diseases. PMID:32183384
Ependymoma Pediatric Brain Tumor Protein Fingerprinting by Integrated Mass Spectrometry Platforms: A Pilot Investigation. PMID:32183175
Genomic Landscape and Mutational Spectrum of ADAMTS Family Genes in Mendelian Disorders Based on Gene Evidence Review for Variant Interpretation. PMID:32183147
Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae. PMID:32182256
Catestatin improves insulin sensitivity by attenuating endoplasmic reticulum stress: In vivo and in silico validation. PMID:32180905
The transcription factor CUX1 negatively regulates invasion in castrate resistant prostate cancer. PMID:32180898
Combination of PD-1 Inhibitor and OX40 Agonist Induces Tumor Rejection and Immune Memory in Mouse Models of Pancreatic Cancer. PMID:32179091
End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression. PMID:32179051
A FITM1-Related Methylation Signature Predicts the Prognosis of Patients With Non-Viral Hepatocellular Carcinoma. PMID:32174969
PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers. PMID:32172476
Machine learning prediction of oncology drug targets based on protein and network properties. PMID:32171238
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake. PMID:32170013
Membrane mucins of the intestine at a glance. PMID:32169835
APEX1 is a novel diagnostic and prognostic biomarker for hepatocellular carcinoma. PMID:32167932
A miRNA- and mRNA-seq-Based Feature Selection Approach for Kidney Cancer Biomakers. PMID:32165847
A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation. PMID:32163402
Toward Development of the Male Pill: A Decade of Potential Non-hormonal Contraceptive Targets. PMID:32161754
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy. PMID:32161261
CD29 identifies IFN-γ-producing human CD8+ T cells with an increased cytotoxic potential. PMID:32161126
Fibroblast-specific genome-scale modelling predicts an imbalance in amino acid metabolism in Refsum disease. PMID:32160399
Genomics and Prognosis Analysis of Epithelial-Mesenchymal Transition in Glioma. PMID:32154177
A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs. PMID:32152546
Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs. PMID:32150922
CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation. PMID:32150608
A putative silencer variant in a spontaneous canine model of retinitis pigmentosa. PMID:32150541
Angiogenin and tRNA fragments in Parkinson's disease and neurodegeneration. PMID:32144338
KCML: a machine-learning framework for inference of multi-scale gene functions from genetic perturbation screens. PMID:32141232
Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases. PMID:32139877
A Caenorhabditis elegans Model for Integrating the Functions of Neuropsychiatric Risk Genes Identifies Components Required for Normal Dendritic Morphology. PMID:32132169
HDMAC: A Web-Based Interactive Program for High-Dimensional Analysis of Molecular Alterations in Cancer. PMID:32127576
Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease. PMID:32127447
The expression landscape of cachexia-inducing factors in human cancers. PMID:32125790
PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression. PMID:32125284
Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes. PMID:32122952
CDX2: A Prognostic Marker in Metastatic Colorectal Cancer Defining a Better BRAF Mutated and a Worse KRAS Mutated Subgroup. PMID:32117703
Identification and validation of key modules and hub genes associated with the pathological stage of oral squamous cell carcinoma by weighted gene co-expression network analysis. PMID:32117620
Germ Cell-Specific Gene 1-Like Protein Regulated by Splicing Factor CUGBP Elav-Like Family Member 5 and Primary Bile Acid Biosynthesis are Prognostic in Glioblastoma Multiforme. PMID:32117422
Tumor-Specific T Cell Activation in Malignant Brain Tumors. PMID:32117316
Expanding Clinical Presentations Due to Variations in THOC2 mRNA Nuclear Export Factor. PMID:32116545
The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. PMID:32116499
Dawn of a New RAMPage. PMID:32115276
FTO Facilitates Lung Adenocarcinoma Cell Progression by Activating Cell Migration Through mRNA Demethylation. PMID:32110044
Endometriotic cell culture contamination and authenticity: a source of bias in in vitro research? PMID:32106286
Insulin-like growth factor-binding proteins play a significant role in the molecular response to imatinib in chronic myeloid leukemia patients. PMID:32104232
Network Pharmacology-Based Investigation of the System-Level Molecular Mechanisms of the Hematopoietic Activity of Samul-Tang, a Traditional Korean Herbal Formula. PMID:32104198
Identification of molecular markers associated with the progression and prognosis of endometrial cancer: a bioinformatic study. PMID:32099532
Identification of putative biomarkers for Infantile Hemangiomas and Propranolol treatment via data integration. PMID:32094357
Two Novel FAM20C Variants in A Family with Raine Syndrome. PMID:32093234
Cytokine-Induced Guanylate Binding Protein 1 (GBP1) Release from Human Ovarian Cancer Cells. PMID:32093058
Transcriptome analyses reveal molecular mechanisms underlying phenotypic differences among transcriptional subtypes of glioblastoma. PMID:32091665
Development of a high affinity Anticalin® directed against human CD98hc for theranostic applications. PMID:32089738
Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D. PMID:32082316
Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers. PMID:32081859
Conditional Disorder in Small Heat-shock Proteins. PMID:32081587
Squamous differentiation requires G2/mitosis slippage to avoid apoptosis. PMID:32080348
The Relevance of Thimet Oligopeptidase in the Regulation of Energy Metabolism and Diet-Induced Obesity. PMID:32079362
Epigenetic Conservation Is a Beacon of Function: An Analysis Using Methcon5 Software for Studying Gene Methylation. PMID:32078366
REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. PMID:32075961
The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins. PMID:32075873
PPP2R5D-Related Intellectual Disability and Neurodevelopmental Delay: A Review of the Current Understanding of the Genetics and Biochemical Basis of the Disorder. PMID:32074998
Comparison of Prostate-Specific Membrane Antigen Expression Levels in Human Salivary Glands to Non-Human Primates and Rodents. PMID:32074455
Validating indicators of CNS disorders in a swine model of neurological disease. PMID:32074109
Neurotoxicity including posterior reversible encephalopathy syndrome after initiation of calcineurin inhibitors in transplanted methylmalonic acidemia patients: Two case reports and review of the literature. PMID:32071844
Integrated analysis of the roles and prognostic value of RNA binding proteins in lung adenocarcinoma. PMID:32071816
A census of pathway maps in cancer systems biology. PMID:32066900
The kinase polypharmacology landscape of clinical PARP inhibitors. PMID:32066817
Large epigenome-wide association study of childhood ADHD identifies peripheral DNA methylation associated with disease and polygenic risk burden. PMID:32066674
HMI-PRED: A Web Server for Structural Prediction of Host-Microbe Interactions Based on Interface Mimicry. PMID:32061934
Restoration of MARCKS enhances chemosensitivity in cancer. PMID:32056006
VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury. PMID:32055648
EGFR modulates complement activation in head and neck squamous cell carcinoma. PMID:32054454
Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions. PMID:32054438
The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β. PMID:32053590
Mechanical regulation of glycolysis via cytoskeleton architecture. PMID:32051585
Using the Gibbs Function as a Measure of Human Brain Development Trends from Fetal Stage to Advanced Age. PMID:32046179
Relationship between NAMPT/PBEF/visfatin and prognosis of patients with malignant tumors: a systematic review and meta-analysis. PMID:32042801
A mutation map for human glycoside hydrolase genes. PMID:32039448
HSD17B13 truncated variant is associated with a mild hepatic phenotype in Wilson's Disease. PMID:32039348
Targeting GPCRs Against Cardiotoxicity Induced by Anticancer Treatments. PMID:32039239
Classification of Trispanins: A Diverse Group of Proteins That Function in Membrane Synthesis and Transport Mechanisms. PMID:32039202
The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer. PMID:32038501
Proteomic profiling and identification of significant markers from high-grade osteosarcoma after cryotherapy and irradiation. PMID:32034162
EV-101: A Phase I Study of Single-Agent Enfortumab Vedotin in Patients With Nectin-4-Positive Solid Tumors, Including Metastatic Urothelial Carcinoma. PMID:32031899
The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling. PMID:32029705
Systematic functional identification of cancer multi-drug resistance genes. PMID:32028983
Protein disulfide isomerases are promising targets for predicting the survival and tumor progression in glioma patients. PMID:32023222
Exploring Metabolic Consequences of CPS1 and CAD Dysregulation in Hepatocellular Carcinoma by Network Reconstruction. PMID:32021853
A Unique Regulation Region in the 3' UTR of HLA-G with a Promising Potential. PMID:32019184
The Water Channel Aquaporin 8 is a Critical Regulator of Intestinal Fluid Homeostasis in Collagenous Colitis. PMID:32016376
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine. PMID:32015474
Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy. PMID:32012846
IGF2BP3 From Physiology to Cancer: Novel Discoveries, Unsolved Issues, and Future Perspectives. PMID:32010687
Identification of differentially expressed protein-coding genes in lung adenocarcinomas. PMID:32010276
Dysregulated lncRNA-miRNA-mRNA Network Reveals Patient Survival-Associated Modules and RNA Binding Proteins in Invasive Breast Carcinoma. PMID:32010179
Complex impact of DNA methylation on transcriptional dysregulation across 22 human cancer types. PMID:32002550
Effect of small molecule signaling in PepFect14 transfection. PMID:31999754
GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents. PMID:31999650
The omics revolution: beyond genomics. A meeting report. PMID:31997976
Senescence-associated genes and non-coding RNAs function in pancreatic cancer progression. PMID:31997706
Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans. PMID:31996024
Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency. PMID:31995689
RNA editing as a therapeutic approach for retinal gene therapy requiring long coding sequences. PMID:31991730
Functional and transcriptomic characterization of cisplatin-resistant AGS and MKN-28 gastric cancer cell lines. PMID:31990955
Exploring genetic targets of psoriasis using genome wide association studies (GWAS) for drug repurposing. PMID:31988837
Fibroblast growth factor signaling in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: Paving the way to hepatocellular carcinoma. PMID:31988589
Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer. PMID:31988584
Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans. PMID:31987839
Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia. PMID:31985809
DNMT1 mutations leading to neurodegeneration paradoxically reflect on mitochondrial metabolism. PMID:31984424
Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation. PMID:31982949
Convergent systems-based approaches identify a role for OCIAD1 in Alzheimer's disease. PMID:31981980
A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population. PMID:31975031
ISOGO: Functional annotation of protein-coding splice variants. PMID:31974522
The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival. PMID:31968056
Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors. PMID:31967407
Aggregation of Omic Data and Secretome Prediction Enable the Discovery of Candidate Plasma Biomarkers for Beef Tenderness. PMID:31963926
Association of α/β-Hydrolase D16B with Bovine Conception Rate and Sperm Plasma Membrane Lipid Composition. PMID:31963602
The Genomes of the Livebearing Fish Species Poeciliopsis retropinna and Poeciliopsis turrubarensis Reflect Their Different Reproductive Strategies. PMID:31960923
Weighted gene co-expression network analysis identifies CCNA2 as a treatment target of prostate cancer through inhibiting cell cycle. PMID:31956366
Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation. PMID:31953380
A comparison of gene expression and DNA methylation patterns across tissues and species. PMID:31953346
Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis. PMID:31953345
The ELIXIR Core Data Resources: fundamental infrastructure for the life sciences. PMID:31950984
miR-TV: an interactive microRNA Target Viewer for microRNA and target gene expression interrogation for human cancer studies. PMID:31950188
Beyond mass spectrometry, the next step in proteomics. PMID:31950079
The Role of Transient Receptor Potential Melastatin 7 (TRPM7) in Cell Viability: A Potential Target to Suppress Breast Cancer Cell Cycle. PMID:31947967
Direct Activation of TRPC3 Channels by the Antimalarial Agent Artemisinin. PMID:31947602
Combined Expression of Plasma Thrombospondin-2 and CA19-9 for Diagnosis of Pancreatic Cancer and Distal Cholangiocarcinoma: A Proteome Approach. PMID:31943574
Polycystin 2 is increased in disease to protect against stress-induced cell death. PMID:31941974
De novo variants in exomes of congenital heart disease patients identify risk genes and pathways. PMID:31941532
Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor. PMID:31940495
Seminal fluid-mediated fitness effects in the simultaneously hermaphroditic flatworm Macrostomum lignano. PMID:31938489
Effect of miR-483-5p on apoptosis of lung cancer cells through targeting of RBM5. PMID:31938444
Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension. PMID:31937874
SeXY chromosomes and the immune system: reflections after a comparative study. PMID:31937374
Differential roles of factors IX and XI in murine placenta and hemostasis under conditions of low tissue factor. PMID:31935292
Integrated assessment of CDK1 upregulation in thyroid cancer. PMID:31934275
The clinicopathological significance of decreased miR-125b-5p in hepatocellular carcinoma: evidence based on RT-qPCR, microRNA-microarray, and microRNA-sequencing. PMID:31933718
Condensation of delta-1-piperideine-6-carboxylate with ortho-aminobenzaldehyde allows its simple, fast, and inexpensive quantification in the urine of patients with antiquitin deficiency. PMID:31930735
A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis. PMID:31928310
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression. PMID:31926610
Integration of IgA and IgG Autoantigens Improves Performance of Biomarker Panels for Early Diagnosis of Lung Cancer. PMID:31924693
Inflammasome expression is higher in ovarian tumors than in normal ovary. PMID:31923221
More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis. PMID:31921102
Live-Cell Assays for Cell Stress Responses Reveal New Patterns of Cell Signaling Caused by Mutations in Rhodopsin, α-Synuclein and TDP-43. PMID:31920544
GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. PMID:31919661
Mechanisms of tissue and cell-type specificity in heritable traits and diseases. PMID:31913361
Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association. PMID:31911620
Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains. PMID:31911579
Differential Expression in Testis and Liver Transcriptomes from Four Species of Peromyscus (Rodentia: Cricetidae). PMID:31909812
DDX3X Multifunctionally Modulates Tumor Progression and Serves as a Prognostic Indicator to Predict Cancer Outcomes. PMID:31906196
A Class II-Restricted CD8γ13 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection. PMID:31899500
TRPV6 as A Target for Cancer Therapy. PMID:31897233
Serum coiled-coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma. PMID:31897206
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion. PMID:31896772
A re-evaluation of LINE-1 ORF2 expression in LNCaP prostate cancer cells. PMID:31890047
High-level integration of murine intestinal transcriptomics data highlights the importance of the complement system in mucosal homeostasis. PMID:31888466
Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin. PMID:31888244
Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System. PMID:31888217
Genetic variation drives seasonal onset of hibernation in the 13-lined ground squirrel. PMID:31886416
Longitudinal serum biomarker screening identifies malate dehydrogenase 2 as candidate prognostic biomarker for Duchenne muscular dystrophy. PMID:31881125
ABC Transporters at the Blood-Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas. PMID:31878061
Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer. PMID:31875161
Substrates, inhibitors, and probes of mammalian transglutaminase 2. PMID:31874171
Quantitative microscopy reveals dynamics and fate of clustered IRE1α. PMID:31871156
Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer. PMID:31871120
The STK16 inhibitor STK16-IN-1 inhibits non-adrenergic and non-neurogenic smooth muscle contractions in the human prostate and the human male detrusor. PMID:31867686
Characterization of Human Dosage-Sensitive Transcription Factor Genes. PMID:31867040
The Thyroid Hormone Receptor-RUNX2 Axis: A Novel Tumor Suppressive Pathway in Breast Cancer. PMID:31865591
Profiling of the plasma proteome across different stages of human heart failure. PMID:31862877
IL35 modulation altered survival, cytokine environment and histopathological consequences during malaria infection in mice. PMID:31856836
Upregulation of β3-adrenoceptors-a general marker of and protective mechanism against hypoxia? PMID:31853614
Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer. PMID:31852841
Transcriptome-Guided Drug Repositioning. PMID:31842375
Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children. PMID:31841498
PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis. PMID:31841108
Single-cell connectomic analysis of adult mammalian lungs. PMID:31840053
High-resolution chromosomal microarray analysis for copy-number variations in high-functioning autism reveals large aberration typical for intellectual disability. PMID:31838600
Pathogenic copy number variants are detected in a subset of patients with gastrointestinal malformations. PMID:31837127
LAMTOR5 raises abnormal initiation of O-glycosylation in breast cancer metastasis via modulating GALNT1 activity. PMID:31836847
Prostate-Derived ETS Factor (PDEF) Modulates Yes Associated Protein 1 (YAP1) in Prostate Cancer Cells: A Potential Cross-Talk between PDEF and Hippo Signaling. PMID:31835563
Loss of RAR-related orphan receptor alpha (RORα) selectively lowers docosahexaenoic acid in developing cerebellum. PMID:31835092
Proteomics: a powerful tool to study plant responses to biotic stress. PMID:31832077
Mapping human N-linked glycoproteins and glycosylation sites using mass spectrometry. PMID:31831916
Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers. PMID:31831737
Identification of microRNAs in skeletal muscle associated with lung cancer cachexia. PMID:31828982
Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry. PMID:31826992
Comprehensive Identification and Characterization of Human Secretome Based on Integrative Proteomic and Transcriptomic Data. PMID:31824949
Development of Immature CD4+CD8+T Cells Into Mature CD4+ T Cells Requires Alpha-1 Antitrypsin as Observed by Treatment in HIV-1 Infected and Uninfected Controls. PMID:31824943
Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer. PMID:31819186
The Fusion of Lipid and DNA Nanotechnology. PMID:31816934
Type I fatty acid synthase trapped in the octanoyl-bound state. PMID:31811668
In Vitro Expansion of Keratinocytes on Human Dermal Fibroblast-Derived Matrix Retains Their Stem-Like Characteristics. PMID:31811191
Ovarian cancer stem cells and targeted therapy. PMID:31810474
Proteogenomics of Colorectal Cancer Liver Metastases: Complementing Precision Oncology with Phenotypic Data. PMID:31805664
Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD. PMID:31805375
Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides. PMID:31802121
Structural basis for the dimerization of Gemin5 and its role in protein recruitment and translation control. PMID:31799608
Casein Kinase 1 Delta Regulates Cell Proliferation, Response to Chemotherapy and Migration in Human Ovarian Cancer Cells. PMID:31799185
Mass Cytometry Imaging for the Study of Human Diseases-Applications and Data Analysis Strategies. PMID:31798587
Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. PMID:31796108
Comparison of tumour and serum specific microRNA changes dissecting their role in pancreatic ductal adenocarcinoma: a meta-analysis. PMID:31795960
The Molecular Genetics of Gordon Syndrome. PMID:31795491
Integrative In Silico and In Vitro Transcriptomics Analysis Revealed Gene Expression Changes and Oncogenic Features of Normal Cholangiocytes after Chronic Alcohol Exposure. PMID:31795085
ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy. PMID:31794718
LASP1 promotes proliferation, metastasis, invasion in head and neck squamous cell carcinoma and through direct interaction with HSPA1A. PMID:31793711
JAK1 as a prognostic marker and its correlation with immune infiltrates in breast cancer. PMID:31790361
Sex-Based Analysis of De Novo Variants in Neurodevelopmental Disorders. PMID:31785789
The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data. PMID:31784565
Programmed DNA elimination of germline development genes in songbirds. PMID:31784533
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function. PMID:31784108
Analysis of the Human Protein Atlas Image Classification competition. PMID:31780840
Rapid affinity purification of intracellular organelles using a twin strep tag. PMID:31780580
Characterizing renal involvement in Hermansky-Pudlak Syndrome in a zebrafish model. PMID:31776394
Chemoenzymatic Semisynthesis of Proteins. PMID:31774265
An omics perspective on drug target discovery platforms. PMID:31774113
Update on KMT2B-Related Dystonia. PMID:31768667
Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease. PMID:31768427
Coauthor Country Affiliations in International Collaborative Research Funded by the US National Institutes of Health, 2009 to 2017. PMID:31755947
CACYBP Enhances Cytoplasmic Retention of P27Kip1 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation. PMID:31754404
Identifying gene function and module connections by the integration of multispecies expression compendia. PMID:31754022
Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location. PMID:31753726
In Situ Analysis Reveals That CFTR Is Expressed in Only a Small Minority of β-Cells in Normal Adult Human Pancreas. PMID:31748811
The Human Immunopeptidome Project: A Roadmap to Predict and Treat Immune Diseases. PMID:31744855
Phenotypic analysis combined with tandem mass tags (TMT) labeling reveal the heterogeneity of strawberry stolon buds. PMID:31744478
The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma. PMID:31739284
Is MYND Domain-Mediated Assembly of SMYD3 Complexes Involved in Calcium Dependent Signaling? PMID:31737645
Comprehensive investigation of key biomarkers and pathways in hepatitis B virus-related hepatocellular carcinoma. PMID:31737106
Expression of CCCTC-binding factor (CTCF) is linked to poor prognosis in prostate cancer. PMID:31736271
Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines. PMID:31733513
Structural basis of the strong cell-cell junction formed by cadherin-23. PMID:31729176
PCOSBase: a manually curated database of polycystic ovarian syndrome. PMID:31725861
The neXtProt knowledgebase in 2020: data, tools and usability improvements. PMID:31724716
Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production. PMID:31721422
Wnt-11 Expression Promotes Invasiveness and Correlates with Survival in Human Pancreatic Ductal Adeno Carcinoma. PMID:31718047
In Silico Study of Rett Syndrome Treatment-Related Genes, MECP2, CDKL5, and FOXG1, by Evolutionary Classification and Disordered Region Assessment. PMID:31717404
Proteomic analysis of eleven tissues in the Chinese giant salamander (Andrias davidianus). PMID:31712686
Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently. PMID:31712655
Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double-Stranded DNA Donors. PMID:31710422
Selective Histone Deacetylase 6 Inhibition Normalizes B Cell Activation and Germinal Center Formation in a Model of Systemic Lupus Erythematosus. PMID:31708928
Gene expression analysis of the cerebellar cortex in essential tremor. PMID:31707044
Megalin: A bridge connecting kidney, the renin-angiotensin system, and atherosclerosis. PMID:31707037
Identifying inaccuracies in gene expression estimates from unstranded RNA-seq data. PMID:31704962
ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress. PMID:31699981
Identification of key candidate genes and molecular pathways in white fat browning: an anti-obesity drug discovery based on computational biology. PMID:31699147
TCR Fingerprinting and Off-Target Peptide Identification. PMID:31695703
Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism. PMID:31693977
3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake. PMID:31692167
Aging results in accumulation of M1 and M2 hepatic macrophages and a differential response to gadolinium chloride. PMID:31691025
Co-regulation map of the human proteome enables identification of protein functions. PMID:31690884
PRADC1: a novel metabolic-responsive secretory protein that modulates physical activity and adiposity. PMID:31689374
CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth. PMID:31685994
ProTstab - predictor for cellular protein stability. PMID:31684883
MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis. PMID:31684860
Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications. PMID:31682939
GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies. PMID:31681577
2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels. PMID:31680972
An expanded mouse testis transcriptome and mass spectrometry defines novel proteins. PMID:31677600
Defining Transcriptional Signatures of Human Hair Follicle Cell States. PMID:31676413
Klf14 is an imprinted transcription factor that regulates placental growth. PMID:31675530
Preprotein signature for full susceptibility to the co-translational translocation inhibitor cyclotriazadisulfonamide. PMID:31675144
Covalently modified carboxyl side chains on cell surface leads to a novel method toward topology analysis of transmembrane proteins. PMID:31673029
Peptides of tetraspanin oncoprotein CD151 trigger active immunity against primary tumour and experimental lung metastasis. PMID:31668880
Focus on FKBP51: A molecular link between stress and metabolic disorders. PMID:31668388
The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly. PMID:31666358
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. PMID:31665640
Unraveling Triple-Negative Breast Cancer Tumor Microenvironment Heterogeneity: Towards an Optimized Treatment Approach. PMID:31665482
The Selective Progesterone Receptor Modulator Ulipristal Acetate Inhibits the Activity of the Glucocorticoid Receptor. PMID:31665442
Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells? PMID:31662755
Brain Region-Specific nAChR and Associated Protein Abundance Alterations Following Chronic Nicotine and/or Menthol Exposure. PMID:31657575
Combinatorial prediction of marker panels from single-cell transcriptomic data. PMID:31657111
PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance. PMID:31655611
MIC_Locator: a novel image-based protein subcellular location multi-label prediction model based on multi-scale monogenic signal representation and intensity encoding strategy. PMID:31655541
ACAT1 and Metabolism-Related Pathways Are Essential for the Progression of Clear Cell Renal Cell Carcinoma (ccRCC), as Determined by Co-expression Network Analysis. PMID:31649873
Oncomodulin: The Enigmatic Parvalbumin Protein. PMID:31649505
Increased CMTM6 can predict the clinical response to PD-1 inhibitors in non-small cell lung cancer patients. PMID:31646074
Gene4Denovo: an integrated database and analytic platform for de novo mutations in humans. PMID:31642496
Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers. PMID:31637211
Proteomics and Metabolomics in Kidney Disease, including Insights into Etiology, Treatment, and Prevention. PMID:31636087
Awakening dormant glycosyltransferases in CHO cells with CRISPRa. PMID:31631317
Selective loss of phosphoserine aminotransferase 1 (PSAT1) suppresses migration, invasion, and experimental metastasis in triple negative breast cancer. PMID:31630284
Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress. PMID:31625393
Sarcomeric myopathies associated with tremor: new insights and perspectives. PMID:31620961
Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease. PMID:31619995
Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines. PMID:31616026
Biological Network Approaches and Applications in Rare Disease Studies. PMID:31614842
Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72. PMID:31612854
Identification of a Nine-Gene Signature and Establishment of a Prognostic Nomogram Predicting Overall Survival of Pancreatic Cancer. PMID:31612115
Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells. PMID:31611601
Candidate Genes and MiRNAs Linked to the Inverse Relationship Between Cancer and Alzheimer's Disease: Insights From Data Mining and Enrichment Analysis. PMID:31608105
Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2. PMID:31605148
Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis. PMID:31602402
Diagnostic and prognostic biomarkers of Human Leukocyte Antigen complex for hepatitis B virus-related hepatocellular carcinoma. PMID:31602270
Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. PMID:31600961
Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. PMID:31599721
Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 3.0. PMID:31599596
snoDB: an interactive database of human snoRNA sequences, abundance and interactions. PMID:31598696
Uterine deficiency of high-mobility group box-1 (HMGB1) protein causes implantation defects and adverse pregnancy outcomes. PMID:31595043
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. PMID:31594949
Absolute Quantification of Apolipoproteins Following Treatment with Omega-3 Carboxylic Acids and Fenofibrate Using a High Precision Stable Isotope-labeled Recombinant Protein Fragments Based SRM Assay. PMID:31591263
Bringing Open Data to Whole Slide Imaging. PMID:31579322
Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel. PMID:31578243
High-Content Imaging for Large-Scale Detection of Low-Affinity Extracellular Protein Interactions. PMID:31578119
Highly heritable and functionally relevant breed differences in dog behaviour. PMID:31575369
Pyk2-dependent phosphorylation of LSR enhances localization of LSR and tricellulin at tricellular tight junctions. PMID:31574128
Pilot-Scale Study Of Human Plasma Proteomics Identifies ApoE And IL33 As Markers In Atopic Asthma. PMID:31571934
Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922. PMID:31569342
Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling. PMID:31568691
Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines. PMID:31565104
Portrait of Tissue-Specific Coexpression Networks of Noncoding RNAs (miRNA and lncRNA) and mRNAs in Normal Tissues. PMID:31565069
PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. PMID:31564549
Tissue-specific mouse mRNA isoform networks. PMID:31562339
Loss of myosin Vb promotes apical bulk endocytosis in neonatal enterocytes. PMID:31562230
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis. PMID:31558756
The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo. PMID:31555430
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling. PMID:31554934
Single-cell transcriptomic profiling of the aging mouse brain. PMID:31551601
Distinct Roles for BET Family Members in Estrogen Receptor α Enhancer Function and Gene Regulation in Breast Cancer Cells. PMID:31551256
SoyCSN: Soybean context-specific network analysis and prediction based on tissue-specific transcriptome data. PMID:31549018
d-amino Acids in Health and Disease: A Focus on Cancer. PMID:31547425
Diagnostic and prognostic values of C‑X‑C motif chemokine ligand 3 in patients with colon cancer. PMID:31545503
Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer. PMID:31545451
FOXN3 hyperglycemic risk allele and insulin sensitivity in humans. PMID:31543974
Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5. PMID:31539416
Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism. PMID:31537871
Characterisation and localisation of the endocannabinoid system components in the adult human testis. PMID:31537814
Dimethylguanidino Valerate: A Lifestyle-Related Metabolite Associated With Future Coronary Artery Disease and Cardiovascular Mortality. PMID:31533499
A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics. PMID:31533246
ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction. PMID:31525885
Dosage regulation, and variation in gene expression and copy number of human Y chromosome ampliconic genes. PMID:31525193
Unsupervised machine learning using an imaging mass spectrometry dataset automatically reassembles grey and white matter. PMID:31519997
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma. PMID:31519915
Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks. PMID:31515267
Control of human testis-specific gene expression. PMID:31514204
The association of integration patterns of human papilloma virus and single nucleotide polymorphisms on immune- or DNA repair-related genes in cervical cancer patients. PMID:31511581
Unexpected roles for ADH1 and SORD in catalyzing the final step of erythritol biosynthesis. PMID:31511322
A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic Approach. PMID:31511258
Hyperglycemia induces spermatogenic disruption via major pathways of diabetes pathogenesis. PMID:31506549
Aberrant Regulation of RAD51 Promotes Resistance of Neoadjuvant Endocrine Therapy in ER-positive Breast Cancer. PMID:31506496
Genome reading by the NF-κB transcription factors. PMID:31501881
HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. PMID:31500569
Analysis of CDKN1C in fetal growth restriction and pregnancy loss. PMID:31497289
Multi-view Subspace Clustering Analysis for Aggregating Multiple Heterogeneous Omics Data. PMID:31497031
High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification. PMID:31495056
A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. PMID:31494632
Neuromedin U: A Small Peptide in the Big World of Cancer. PMID:31492042
Copy number variants in lipid metabolism genes are associated with gallstones disease in men. PMID:31485028
The Coxsackievirus and Adenovirus Receptor, a Required Host Factor for Recovirus Infection, Is a Putative Enteric Calicivirus Receptor. PMID:31484750
Relative stabilities of wild-type and mutant glial fibrillary acidic protein in patients with Alexander disease. PMID:31484723
Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome. PMID:31481669
Syndecan-Mediated Ligation of ECM Proteins Triggers Proliferative Arrest of Disseminated Tumor Cells. PMID:31481497
The Known and Potential Intersections of Rab-GTPases in Human Papillomavirus Infections. PMID:31475144
Dynamical Electrical Complexity Is Reduced during Neuronal Differentiation in Autism Spectrum Disorder. PMID:31474529
Minor intron splicing revisited: identification of new minor intron-containing genes and tissue-dependent retention and alternative splicing of minor introns. PMID:31470809
Mesencephalic Astrocyte-Derived Neurotrophic Factor Inhibits Liver Cancer Through Small Ubiquitin-Related Modifier (SUMO)ylation-Related Suppression of NF-κB/Snail Signaling Pathway and Epithelial-Mesenchymal Transition. PMID:31469428
DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases. PMID:31467668
Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer. PMID:31467540
Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-β fibrils. PMID:31467325
Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2. PMID:31466081
Stoichioproteomics reveal oxygen usage bias, key proteins and pathways in glioma. PMID:31464612
The effects of di-butyl phthalate exposure from medications on human sperm RNA among men. PMID:31455814
Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy. PMID:31452838
Screening of potential biomarkers in hepatitis C virus-induced hepatocellular carcinoma using bioinformatic analysis. PMID:31452738
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program. PMID:31451708
Divide and conquer: two stem cell populations in squamous epithelia, reserves and the active duty forces. PMID:31451683
Construction and Investigation of a lncRNA-Associated ceRNA Regulatory Network in Cholangiocarcinoma. PMID:31448221
Target Genes of Autism Risk Loci in Brain Frontal Cortex. PMID:31447881
Expression Levels of 4 Genes in Colon Tissue Might Be Used to Predict Which Patients Will Enter Endoscopic Remission After Vedolizumab Therapy for Inflammatory Bowel Diseases. PMID:31446181
A phase I study of enfortumab vedotin in Japanese patients with locally advanced or metastatic urothelial carcinoma. PMID:31444589
Differential gene expression and gene-set enrichment analysis in Caco-2 monolayers during a 30-day timeline with Dexamethasone exposure. PMID:31438773
Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination. PMID:31437751
Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice Phenotype Characterization. PMID:31431000
Progress on Identifying and Characterizing the Human Proteome: 2019 Metrics from the HUPO Human Proteome Project. PMID:31430157
Localization-specific distributions of protein pI in human proteome are governed by local pH and membrane charge. PMID:31429701
Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues. PMID:31427819
Rho GTPases in cancer: friend or foe? PMID:31427738
KCNMA1-linked channelopathy. PMID:31427379
Cdh4 Down-Regulation Impairs in Vivo Infiltration and Malignancy in Patients Derived Glioblastoma Cells. PMID:31426573
Deciphering GRINA/Lifeguard1: Nuclear Location, Ca2+ Homeostasis and Vesicle Transport. PMID:31426446
Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism. PMID:31422917
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. PMID:31422913
Loss of microfibril-associated protein 5 (MFAP5) expression in colon cancer stroma. PMID:31422503
Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling. PMID:31421261
Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic Modeling. PMID:31417867
A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. PMID:31417100
The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation. PMID:31409643
The analysis of risk factors for diabetic nephropathy progression and the construction of a prognostic database for chronic kidney diseases. PMID:31409386
Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses. PMID:31408441
Furin-mediated protein processing in infectious diseases and cancer. PMID:31406574
MicroRNA let-7-TGFBR3 signalling regulates cardiomyocyte apoptosis after infarction. PMID:31401194
A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination. PMID:31399485
Targeting CDK9 for treatment of colorectal cancer. PMID:31398271
Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs. PMID:31396219
DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease. PMID:31387232
Adaptation to Extreme Environments in an Admixed Human Population from the Atacama Desert. PMID:31384924
Stoichiogenomics reveal oxygen usage bias, key proteins and pathways associated with stomach cancer. PMID:31383879
The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells. PMID:31381610
Computational Analysis of HLA-presentation of Non-synonymous Recipient Mismatches Indicates Effect on the Risk of Chronic Graft-vs.-Host Disease After Allogeneic HSCT. PMID:31379830
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5. PMID:31379819
Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells. PMID:31379806
Molecular Systems Biology of Neurodevelopmental Disorders, Rett Syndrome as an Archetype. PMID:31379529
Mapping Interactions of Microbial Metabolites with Human G-Protein-Coupled Receptors. PMID:31378678
A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology. PMID:31378672
Exploring the molecular basis of neuronal excitability in a vocal learner. PMID:31375088
Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A. PMID:31374199
The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour. PMID:31371726
Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma. PMID:31369399
Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions. PMID:31367837
Relating evolutionary selection and mutant clonal dynamics in normal epithelia. PMID:31362624
Comprehensive analysis of differentially expressed circRNAs revealed a ceRNA network in pancreatic ductaladenocarcinoma. PMID:31360192
T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance. PMID:31355495
Promoter conservation in HDACs points to functional implications. PMID:31351464
The genome of the live-bearing fish Heterandria formosa implicates a role of conserved vertebrate genes in the evolution of placental fish. PMID:31349784
Decreased expression of SLC16A12 mRNA predicts poor prognosis of patients with clear cell renal cell carcinoma. PMID:31348313
Exosome release and cargo in Down syndrome. PMID:31347291
Intrinsic expression of viperin regulates thermogenesis in adipose tissues. PMID:31341090
The diagnostic and prognostic role of RhoA in hepatocellular carcinoma. PMID:31339860
Chemotactic Ligands that Activate G-Protein-Coupled Formylpeptide Receptors. PMID:31336833
Upregulation of nucleoprotein AHNAK is associated with poor outcome of pancreatic ductal adenocarcinoma prognosis via mediating epithelial-mesenchymal transition. PMID:31333803
Gene Therapy Corrects Brain and Behavioral Pathologies in CLN6-Batten Disease. PMID:31331814
AKAP6 and phospholamban colocalize and interact in HEK-293T cells and primary murine cardiomyocytes. PMID:31325238
Estimating dispensable content in the human interactome. PMID:31324802
Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer. PMID:31324208
Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis. PMID:31324198
Assessing key decisions for transcriptomic data integration in biochemical networks. PMID:31323017
Transcriptional control and transcriptomic analysis of lipid metabolism in skin barrier formation and atopic dermatitis (AD). PMID:31322970
Identification of a missense variant in CLDN2 in obstructive azoospermia. PMID:31320686
Computational Drug Screening Identifies Compounds Targeting Renal Age-associated Molecular Profiles. PMID:31316728
The Warburg Effect Is Associated With Tumor Aggressiveness in Testicular Germ Cell Tumors. PMID:31316469
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. PMID:31316208
Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis. PMID:31316008
Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production. PMID:31311960
Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells. PMID:31311882
Identification of novel genes associated with a poor prognosis in pancreatic ductal adenocarcinoma via a bioinformatics analysis. PMID:31311829
Exploring the Molecular Mechanism of the Drug-Treated Breast Cancer Based on Gene Expression Microarray. PMID:31311202
Clinical update on head and neck cancer: molecular biology and ongoing challenges. PMID:31308358
Small-protein Enrichment Assay Enables the Rapid, Unbiased Analysis of Over 100 Low Abundance Factors from Human Plasma. PMID:31308252
Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer. PMID:31307411
Benchmarking subcellular localization and variant tolerance predictors on membrane proteins. PMID:31307390
Identification and analysis of genes associated with head and neck squamous cell carcinoma by integrated bioinformatics methods. PMID:31304688
Cardiac tissue engineering: state-of-the-art methods and outlook. PMID:31297148
Retention of paternal DNA methylome in the developing zebrafish germline. PMID:31296860
A human liver cell atlas reveals heterogeneity and epithelial progenitors. PMID:31292543
Landscape of innate immune system transcriptome and acute T cell-mediated rejection of human kidney allografts. PMID:31292297
Tubulin glutamylation: a skeleton key for neurodegenerative diseases. PMID:31290441
The heterogeneity and complexity of Cannabis extracts as antitumor agents. PMID:31289609
Mapping the protein-protein and genetic interactions of cancer to guide precision medicine. PMID:31288129
Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility. PMID:31285581
Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes. PMID:31282863
Genome-wide functional association networks: background, data & state-of-the-art resources. PMID:31281921
CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. PMID:31281901
Co-expression network analysis identified candidate biomarkers in association with progression and prognosis of breast cancer. PMID:31280346
Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study. PMID:31277479
Large HERCs Function as Tumor Suppressors. PMID:31275856
Milk proteome from in silico data aggregation allows the identification of putative biomarkers of negative energy balance in dairy cows. PMID:31273261
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants. PMID:31273118
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. PMID:31268602
Integrating proteomics and transcriptomics for the identification of potential targets in early colorectal cancer. PMID:31268166
In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes. PMID:31265809
Whole-exome sequencing of ovarian cancer families uncovers putative predisposition genes. PMID:31265121
Genome-wide association analysis uncovers variants for reproductive variation across dog breeds and links to domestication. PMID:31263560
Germline BRCA1 Mutation Detected in a Multiple Endocrine Neoplasia Type 2 Case With RET Codon 634 Mutation. PMID:31263477
Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14. PMID:31261654
Transcriptomes of antigen presenting cells in human thymus. PMID:31261375
Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells. PMID:31260037
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation. PMID:31253574
Quantitative Systems Pharmacology Model of a Masked, Tumor-Activated Antibody. PMID:31250966
Best practices and benchmarks for intact protein analysis for top-down mass spectrometry. PMID:31249407
A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys. PMID:31249312
Multi-omics Biomarker Pipeline Reveals Elevated Levels of Protein-glutamine Gamma-glutamyltransferase 4 in Seminal Plasma of Prostate Cancer Patients. PMID:31249104
Estimation of allele-specific fitness effects across human protein-coding sequences and implications for disease. PMID:31249063
Leveraging the Role of the Metastatic Associated Protein Anterior Gradient Homologue 2 in Unfolded Protein Degradation: A Novel Therapeutic Biomarker for Cancer. PMID:31247903
Biological Pathway Specificity in the Cell-Does Molecular Diversity Matter? PMID:31245864
A Circulating Tumor Cell-RNA Assay for Assessment of Androgen Receptor Signaling Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer. PMID:31244925
Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'. PMID:31244471
Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics. PMID:31243108
Parent-of-origin-specific allelic expression in the human placenta is limited to established imprinted loci and it is stably maintained across pregnancy. PMID:31242935
Proteolytic Rafts for Improving Intraparenchymal Migration of Minimally Invasively Administered Hydrogel-Embedded Stem Cells. PMID:31238564
The roles of the human SETMAR (Metnase) protein in illegitimate DNA recombination and non-homologous end joining repair. PMID:31238295
Unified single-cell analysis of testis gene regulation and pathology in five mouse strains. PMID:31237565
Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer. PMID:31233188
Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults. PMID:31231205
Characterization of Contractile Proteins from Skeletal Muscle Using Gel-Based Top-Down Proteomics. PMID:31226838
The role of hydrophobic matching on transmembrane helix packing in cells. PMID:31225439
CNBP controls transcription by unfolding DNA G-quadruplex structures. PMID:31219592
Gene Information eXtension (GIX): effortless retrieval of gene product information on any website. PMID:31217594
Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease. PMID:31217356
HNF4α and CDX2 Regulate Intestinal YAP1 Promoter Activity. PMID:31216773
Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective. PMID:31216675
Consequences of Y chromosome microdeletions beyond male infertility. PMID:31214882
The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease. PMID:31214167
Signatures of Recent Positive Selection in Enhancers Across 41 Human Tissues. PMID:31213516
Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium. PMID:31209240
Genetic Mutations Underlying Phenotypic Plasticity in Basosquamous Carcinoma. PMID:31207229
Development of a predictive model for stromal content in prostate cancer samples to improve signature performance. PMID:31206668
The p52 isoform of SHC1 is a key driver of breast cancer initiation. PMID:31202267
Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia. PMID:31200555
Current status and applications of genome-scale metabolic models. PMID:31196170
Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial-mesenchymal transition. PMID:31196164
LncRRIsearch: A Web Server for lncRNA-RNA Interaction Prediction Integrated With Tissue-Specific Expression and Subcellular Localization Data. PMID:31191601
Molecular Mechanisms by Which Selenoprotein K Regulates Immunity and Cancer. PMID:31187393
Indoleamine 2,3-dioxygenase and ischemic heart disease: a Mendelian Randomization study. PMID:31186442
Dynamic genome-scale cell-specific metabolic models reveal novel inter-cellular and intra-cellular metabolic communications during ovarian follicle development. PMID:31182013
Spliced X-box Binding Protein 1 Stimulates Adaptive Growth Through Activation of mTOR. PMID:31177839
A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation. PMID:31172184
HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis. PMID:31163988
Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities. PMID:31160710
Bridging the gap between reference and real transcriptomes. PMID:31159855
Small molecule target identification using photo-affinity chromatography. PMID:31155061
Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma. PMID:31154438
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. PMID:31149896
Eleven genes associated with progression and prognosis of endometrial cancer (EC) identified by comprehensive bioinformatics analysis. PMID:31139013
Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C. PMID:31138701
Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies. PMID:31130731
The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination. PMID:31127291
Exploiting Interdata Relationships in Next-generation Proteomics Analysis. PMID:31126983
Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway. PMID:31118659
Angiotensin II-mediated MYH9 downregulation causes structural and functional podocyte injury in diabetic kidney disease. PMID:31118506
Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development. PMID:31116975
ResponseNet v.3: revealing signaling and regulatory pathways connecting your proteins and genes across human tissues. PMID:31114913
Increased expression of TMED2 is an unfavorable prognostic factor in patients with breast cancer. PMID:31114314
RIP2 promotes FcγR-mediated reactive oxygen species production. PMID:31113864
A novel conserved family of Macro-like domains-putative new players in ADP-ribosylation signaling. PMID:31106069
Secretomes from metastatic breast cancer cells, enriched for a prognostically unfavorable LCN2 axis, induce anti-inflammatory MSC actions and a tumor-supportive premetastatic lung. PMID:31105883
Expression profile and functional role of S100A14 in human cancer. PMID:31105881
Gi/o-Protein Coupled Receptors in the Aging Brain. PMID:31105551
Fatty Acid Signaling Mechanisms in Neural Cells: Fatty Acid Receptors. PMID:31105530
Meiotic gene activation in somatic and germ cell tumours. PMID:31102330
Expression of Glypican 3 is an Independent Prognostic Biomarker in Primary Gastro-Esophageal Adenocarcinoma and Corresponding Serum Exosomes. PMID:31100935
Silencing of Aberrant Secretory Protein Expression by Disease-Associated Mutations. PMID:31100385
The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells. PMID:31097295
Profiling Autoantibodies against Salivary Proteins in Sicca Conditions. PMID:31095438
Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling. PMID:31087223
PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. PMID:31086175
c-Met as a new marker of cellular senescence. PMID:31085799
Genome-wide analyses of psychological resilience in U.S. Army soldiers. PMID:31081985
The clinical spectrum of the congenital myasthenic syndrome resulting from COL13A1 mutations. PMID:31081514
Pseudomonas aeruginosa-derived pyocyanin reduces adipocyte differentiation, body weight, and fat mass as mechanisms contributing to septic cachexia. PMID:31078726
Tissue-specific genes as an underutilized resource in drug discovery. PMID:31076736
Cryo-Electron Tomography and Proteomics studies of centrosomes from differentiated quiescent thymocytes. PMID:31076588
Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients. PMID:31070306
Metabolic enzymes expressed by cancer cells impact the immune infiltrate. PMID:31069148
Large-scale in-silico identification of a tumor-specific antigen pool for targeted immunotherapy in triple-negative breast cancer. PMID:31069014
Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells. PMID:31068932
g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). PMID:31066453
Epigenome-wide DNA methylation in placentas from preterm infants: association with maternal socioeconomic status. PMID:31062658
Targeting the High-Mobility Group Box 3 Protein Sensitizes Chemoresistant Ovarian Cancer Cells to Cisplatin. PMID:31061066
FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane. PMID:31056421
The SUMO-Specific Protease Senp2 Regulates SUMOylation, Expression and Function of Human Organic Anion Transporter 3. PMID:31054272
Actin-tropomyosin distribution in non-muscle cells. PMID:31054005
Characterization of CNPY5 and its family members. PMID:31050855
Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function. PMID:31048406
MetAP2 inhibition increases energy expenditure through direct action on brown adipocytes. PMID:31048375
Divergent effects of vitamins K1 and K2 on triple negative breast cancer cells. PMID:31040920
A nanobody-based molecular toolkit provides new mechanistic insight into clathrin-coat initiation. PMID:31038455
Soluble Heparin Binding Epidermal Growth Factor-Like Growth Factor Is a Regulator of GALGT2 Expression and GALGT2-Dependent Muscle and Neuromuscular Phenotypes. PMID:31036568
Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling. PMID:31035605
Network Medicine in the Age of Biomedical Big Data. PMID:31031797
Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals. PMID:31031010
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. PMID:31028174
The Fate of Glutamine in Human Metabolism. The Interplay with Glucose in Proliferating Cells. PMID:31027329
PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel. PMID:31023925
Strategies for Network GWAS Evaluated Using Classroom Crowd Science. PMID:31022372
A Bioinformatics View of Glycan⁻Virus Interactions. PMID:31018588
Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition. PMID:31018575
Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis. PMID:31018140
YAP-independent mechanotransduction drives breast cancer progression. PMID:31015465
eIF4G2 balances its own mRNA translation via a PCBP2-based feedback loop. PMID:31010886
Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer. PMID:31003445
Transcriptome Analysis Revealed a Highly Connected Gene Module Associated With Cirrhosis to Hepatocellular Carcinoma Development. PMID:31001331
Targeting Tumor Vascular CD99 Inhibits Tumor Growth. PMID:31001265
Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask). PMID:30995798
Crystal structure of human RIOK2 bound to a specific inhibitor. PMID:30991936
Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability. PMID:30990168
Myometrial Transcriptional Signatures of Human Parturition. PMID:30988671
Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates. PMID:30988006
IFITM3: How genetics influence influenza infection demographically. PMID:30987701
Proteomic Analysis Implicates Vimentin in Glioblastoma Cell Migration. PMID:30987208
Increasing consensus of context-specific metabolic models by integrating data-inferred cell functions. PMID:30986217
Quantitative Proteomic Analysis of Human Seminal Plasma from Normozoospermic and Asthenozoospermic Individuals. PMID:30984777
Cell migration and proliferation are regulated by miR-26a in colorectal cancer via the PTEN-AKT axis. PMID:30983885
Tspan8 is expressed in breast cancer and regulates E-cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles. PMID:30982971
CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids. PMID:30982469
Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies. PMID:30974124
In silico Characterization of Human Prion-Like Proteins: Beyond Neurological Diseases. PMID:30971948
Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner. PMID:30971297
Systems Biology Reveals NR2F6 and TGFB1 as Key Regulators of Feed Efficiency in Beef Cattle. PMID:30967894
Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor. PMID:30965276
Analysis of the role of the Hippo pathway in cancer. PMID:30961610
Androgen deprivation therapy promotes an obesity-like microenvironment in periprostatic fat. PMID:30959474
In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta. PMID:30958262
Proteomic studies of bone and skeletal health outcomes. PMID:30954730
Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects. PMID:30952858
Prognostic role of cyclin D2/D3 in multiple human malignant neoplasms: A systematic review and meta-analysis. PMID:30950241
Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory. PMID:30948719
Genome-wide Analysis of Common Copy Number Variation and Epithelial Ovarian Cancer Risk. PMID:30948450
Inflammation: A key process in skin tumorigenesis. PMID:30944600
Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles. PMID:30943406
BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers. PMID:30941229
Fetal lung C4BPA induces p100 processing in human placenta. PMID:30940885
The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. PMID:30930166
Evaluation and Interpretation of Transcriptome Data Underlying Heterogeneous Chronic Obstructive Pulmonary Disease. PMID:30929403
EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma. PMID:30923826
Serum endostatin levels are associated with diffusion capacity and with tuberous sclerosis- associated lymphangioleiomyomatosis. PMID:30922357
The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population. PMID:30920136
Multifactorial Contribution of Notch Signaling in Head and Neck Squamous Cell Carcinoma. PMID:30917608
Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator. PMID:30916349
Melanoma-Induced Reprogramming of Schwann Cell Signaling Aids Tumor Growth. PMID:30914431
Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients. PMID:30914425
Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis. PMID:30906868
Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1. PMID:30906261
Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning. PMID:30905848
Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage. PMID:30900988
Evolutionary and functional implications of 3' untranslated region length of mRNAs by comprehensive investigation among four taxonomically diverse metazoan species. PMID:30900191
Diagnostic and prognostic value of mRNA expression of phospholipase C β family genes in hepatitis B virus‑associated hepatocellular carcinoma. PMID:30896816
Comprehensive Analysis of Individual Variation in the Urinary Proteome Revealed Significant Gender Differences. PMID:30894400
Proteomic Analysis of Human Plasma during Intermittent Fasting. PMID:30892045
Hexosamine Biosynthetic Pathway and Glycosylation Regulate Cell Migration in Melanoma Cells. PMID:30891426
Identifying and exploiting gene-pathway interactions from RNA-seq data for binary phenotype. PMID:30890140
Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. PMID:30889382
Primate piRNA Cluster Evolution Suggests Limited Relevance of Pseudogenes in piRNA-Mediated Gene Regulation. PMID:30888404
Identification of Important Effector Proteins in the FOXJ1 Transcriptional Network Associated With Ciliogenesis and Ciliary Function. PMID:30881373
Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer. PMID:30875794
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy. PMID:30873179
Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis. PMID:30872636
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma. PMID:30872592
Regulation of proline-directed kinases and the trans-histone code H3K9me3/H4K20me3 during human myogenesis. PMID:30872405
netDx: interpretable patient classification using integrated patient similarity networks. PMID:30872331
β3 -Adrenoceptors in the normal and diseased urinary bladder-What are the open questions? PMID:30868554
Post-transcriptional regulatory patterns revealed by protein-RNA interactions. PMID:30867517
Aberrant DOCK2, GRASP, HIF3A and PKFP Hypermethylation has Potential as a Prognostic Biomarker for Prostate Cancer. PMID:30866497
A novel Microproteomic Approach Using Laser Capture Microdissection to Study Cellular Protrusions. PMID:30866487
A systematic review and standardized clinical validity assessment of male infertility genes. PMID:30865283
LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3. PMID:30858559
The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1. PMID:30858459
UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation. PMID:30858178
Clinical Stratification of High-Grade Ovarian Serous Carcinoma Using a Panel of Six Biomarkers. PMID:30857227
A network-based approach to identify DNA methylation and its involved molecular pathways in testicular germ cell tumors. PMID:30854095
Emerging drug development technologies targeting ubiquitination for cancer therapeutics. PMID:30851297
Increased LGALS3 expression independently predicts shorter overall survival in patients with the proneural subtype of glioblastoma. PMID:30848102
Genome-wide meta-analysis identifies novel loci associated with free triiodothyronine and thyroid-stimulating hormone. PMID:30843173
S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. PMID:30842656
HER2 Directed Antibody-Drug-Conjugates beyond T-DM1 in Breast Cancer. PMID:30841523
A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome. PMID:30840886
Geometric characterisation of disease modules. PMID:30839777
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion. PMID:30836712
Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle. PMID:30835510
Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion. PMID:30835257
A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing. PMID:30829570
Regulation of Microbiota by Vitamin D Receptor: A Nuclear Weapon in Metabolic Diseases. PMID:30828578
Isoform-specific GSK3A activity is negatively correlated with human sperm motility. PMID:30824926
Selecting variants of unknown significance through network-based gene-association significantly improves risk prediction for disease-control cohorts. PMID:30824863
Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors. PMID:30823893
COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis. PMID:30819896
Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard. PMID:30819892
Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia. PMID:30819197
Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail. PMID:30818851
In silico analysis identified miRNA‑based therapeutic agents against glioblastoma multiforme. PMID:30816530
Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior. PMID:30814913
MicroRNAs from saliva of anopheline mosquitoes mimic human endogenous miRNAs and may contribute to vector-host-pathogen interactions. PMID:30814633
Comparative analyses of sperm DNA methylomes among human, mouse and cattle provide insights into epigenomic evolution and complex traits. PMID:30810461
Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells. PMID:30810435
NOD1: An Interface Between Innate Immunity and Insulin Resistance. PMID:30807635
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. PMID:30804560
Proteomic Maps of Human Gastrointestinal Stromal Tumor Subgroups. PMID:30804049
UBTD1 is a mechano-regulator controlling cancer aggressiveness. PMID:30804013
Cardiac β3 -adrenoceptors-A role in human pathophysiology? PMID:30801686
Clinical Transcriptome Sequencing Confirms Activation of a Cryptic Splice Site in Suspected SYNGAP1-Related Disorder. PMID:30800045
The Emerging World of TCR-T Cell Trials Against Cancer: A Systematic Review. PMID:30798772
Predicted secreted protein analysis reveals synaptogenic function of Clstn3 during WAT browning and BAT activation in mice. PMID:30796355
Genomic landscape of a metastatic malignant proliferating tricholemmal tumor and its response to PI3K inhibition. PMID:30793038
Down-regulation of FZD3 receptor suppresses growth and metastasis of human melanoma independently of canonical WNT signaling. PMID:30792348
Human colon organoids reveal distinct physiologic and oncogenic Wnt responses. PMID:30792186
Comprehensive clinical implications of homeobox A10 in 3,199 cases of non-small cell lung cancer tissue samples combining qRT-PCR, RNA sequencing and microarray data. PMID:30787969
MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon. PMID:30784582
Cellular Compartmentation and the Redox/Nonredox Functions of NAD. PMID:30784294
Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer. PMID:30781493
Molecular crypsis by pathogenic fungi using human factor H. A numerical model. PMID:30779817
Towards a data-integrated cell. PMID:30778056
Quantification and discovery of sequence determinants of protein-per-mRNA amount in 29 human tissues. PMID:30777893
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues. PMID:30777892
A Cholesterol Analog Induces an Oligomeric Reorganization of VDAC. PMID:30777305
Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas. PMID:30777055
The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation. PMID:30770239
Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring. PMID:30768568
Flotillin1 promotes EMT of human small cell lung cancer via TGF-β signaling pathway. PMID:30766750
MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma. PMID:30765601
Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. PMID:30760538
PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq. PMID:30759402
Survival in a bad neighborhood: pancreatic islets in cystic fibrosis. PMID:30759072
Identification of special key genes for alcohol-related hepatocellular carcinoma through bioinformatic analysis. PMID:30755830
Eradication of glioblastoma by immuno-virotherapy with a retargeted oncolytic HSV in a preclinical model. PMID:30755732
CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3. PMID:30755730
Integrated bioinformatics analysis of key genes involved in progress of colon cancer. PMID:30746900
SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro. PMID:30744170
Histamine N-Methyltransferase in the Brain. PMID:30744146
Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma. PMID:30736807
Predicting clinically promising therapeutic hypotheses using tensor factorization. PMID:30736745
Proteomic Atlas of the Human Brain in Alzheimer's Disease. PMID:30735395
The antimicrobial protein S100A12 identified as a potential autoantigen in a subgroup of atopic dermatitis patients. PMID:30728947
WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial-mesenchymal transition. PMID:30723155
PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling. PMID:30718277
Conserved regulation of RNA processing in somatic cell reprogramming. PMID:30704403
Heart failure in cancer: role of checkpoint inhibitors. PMID:30701100
Mass Spectrometry-based Absolute Quantification of 20S Proteasome Status for Controlled Ex-vivo Expansion of Human Adipose-derived Mesenchymal Stromal/Stem Cells. PMID:30700495
Detecting Secretory Proteins by Acoustic Droplet Ejection in Multiplexed High-Throughput Applications. PMID:30699290
Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion. PMID:30698726
Spatial Principles of Chromatin Architecture Associated With Organ-Specific Gene Regulation. PMID:30697540
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules. PMID:30693281
Cadherin 11 Inhibition Downregulates β-catenin, Deactivates the Canonical WNT Signalling Pathway and Suppresses the Cancer Stem Cell-Like Phenotype of Triple Negative Breast Cancer. PMID:30691241
Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4. PMID:30691220
Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. PMID:30685239
Are we listening to everything the PARK genes are telling us? PMID:30680728
NKL homeobox gene NKX2-2 is aberrantly expressed in Hodgkin lymphoma. PMID:30680064
A Retrospective Analysis of the Cartilage Kunitz Protease Inhibitory Proteins Identifies These as Members of the Inter-α-Trypsin Inhibitor Superfamily with Potential Roles in the Protection of the Articulatory Surface. PMID:30678366
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation. PMID:30674441
Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer. PMID:30670910
Gut microbiota profiling with differential tolerance against the reduced dietary fibre level in rabbit. PMID:30670754
PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights. PMID:30668673
miR663a‑TTC22V1 axis inhibits colon cancer metastasis. PMID:30664167
Mucosal IL13RA2 expression predicts nonresponse to anti-TNF therapy in Crohn's disease. PMID:30663072
Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression. PMID:30661928
Combining LOPIT with differential ultracentrifugation for high-resolution spatial proteomics. PMID:30659192
VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site. PMID:30657523
The RANK-RANKL axis: an opportunity for drug repurposing in cancer? PMID:30656607
RiboTag translatomic profiling of Drosophila oenocytes under aging and induced oxidative stress. PMID:30651069
Large-scale analysis of human gene expression variability associates highly variable drug targets with lower drug effectiveness and safety. PMID:30649201
Elucidation of the functional roles of the Q and I motifs in the human chromatin-remodeling enzyme BRG1. PMID:30647132
Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation. PMID:30639098
Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target. PMID:30635167
Leveraging Multilayered "Omics" Data for Atopic Dermatitis: A Road Map to Precision Medicine. PMID:30631320
Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis. PMID:30629778
Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy. PMID:30628708
Organoid single cell profiling identifies a transcriptional signature of glomerular disease. PMID:30626756
Variations in HPV function are associated with survival in squamous cell carcinoma. PMID:30626753
Cancer Connectors: Connexins, Gap Junctions, and Communication. PMID:30622930
Wireless Electrochemical Detection on a Microfluidic Compact Disc (CD) and Evaluation of Redox-Amplification during Flow. PMID:30621031
The Importance of Biologic Knowledge and Gene Expression Context for Genomic Data Interpretation. PMID:30619486
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. PMID:30617275
Systems-based approaches for investigation of inter-tissue communication. PMID:30617149
Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis. PMID:30606699
The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens. PMID:30606230
Clinical significance and biological role of cancer-derived Type I collagen in lung and esophageal cancers. PMID:30604926
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies. PMID:30604766
A region-resolved mucosa proteome of the human stomach. PMID:30604760
Alterations in sialic-acid O-acetylation glycoforms during murine erythrocyte development. PMID:30597004
miR‑675 promotes colorectal cancer cell growth dependent on tumor suppressor DMTF1. PMID:30592263
Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus. PMID:30591584
The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass. PMID:30588560
Oncogenic Role of Tumor Necrosis Factor α-Induced Protein 8 (TNFAIP8). PMID:30586922
Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community. PMID:30580566
Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients. PMID:30578919
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. PMID:30578418
A locus on chromosome 5 shows African ancestry-limited association with alloimmunization in sickle cell disease. PMID:30578281
Novel circular RNA circNF1 acts as a molecular sponge, promoting gastric cancer by absorbing miR-16. PMID:30576282
Calmodulinopathy: A Novel, Life-Threatening Clinical Entity Affecting the Young. PMID:30574507
Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells. PMID:30573509
Proteomic Analysis of the Human Anterior Pituitary Gland. PMID:30571610
Cell Hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics. PMID:30567574
NAD Metabolome Analysis in Human Cells Using ¹H NMR Spectroscopy. PMID:30563212
Diagnosing rare diseases after the exome. PMID:30559314
Intrinsic Dynamics of a Human Gene Reveal the Basis of Expression Heterogeneity. PMID:30554876
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis. PMID:30554520
How many cadherins do human endothelial cells express? PMID:30552441
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. PMID:30552067
B cells in esophago-gastric adenocarcinoma are highly differentiated, organize in tertiary lymphoid structures and produce tumor-specific antibodies. PMID:30546950
Targeted Delivery of TNF Potentiates the Antibody-Dependent Cell-Mediated Cytotoxicity of an Anti-Melanoma Immunoglobulin. PMID:30543899
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. PMID:30542056
Analysis of 3D genomic interactions identifies candidate host genes that transposable elements potentially regulate. PMID:30541598
PopViz: a webserver for visualizing minor allele frequencies and damage prediction scores of human genetic variations. PMID:30535305
Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease. PMID:30533169
Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition. PMID:30532030
Loss of Ca2+/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease. PMID:30525042
Borders of Cis-Regulatory DNA Sequences Preferentially Harbor the Divergent Transcription Factor Binding Motifs in the Human Genome. PMID:30524473
Proteome-wide Tyrosine Phosphorylation Analysis Reveals Dysregulated Signaling Pathways in Ovarian Tumors. PMID:30523211
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. PMID:30518876
Stable-protein Pair Analysis as A Novel Strategy to Identify Proteomic Signatures: Application To Seminal Plasma From Infertile Patients. PMID:30518674
Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing. PMID:30514914
The Role of Cystinosin in the Intermediary Thiol Metabolism and Redox Homeostasis in Kidney Proximal Tubular Cells. PMID:30513914
Molecular characterization and biomarker identification in colorectal cancer: Toward realization of the precision medicine dream. PMID:30510457
Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin. PMID:30508377
The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes. PMID:30504233
2C-BioID: An Advanced Two Component BioID System for Precision Mapping of Protein Interactomes. PMID:30500481
Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems. PMID:30487642
Novel in Vitro Method Reveals Drugs That Inhibit Organic Solute Transporter Alpha/Beta (OSTα/β). PMID:30481467
Identification of RPL5 and RPL10 as novel diagnostic biomarkers of Atypical teratoid/rhabdoid tumors. PMID:30479569
Prostate-specific markers to identify rare prostate cancer cells in liquid biopsies. PMID:30479377
Pooled extracellular receptor-ligand interaction screening using CRISPR activation. PMID:30477585
Frailty Index associates with GRIN2B in two representative samples from the United States and the United Kingdom. PMID:30475886
FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer. PMID:30475207
Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma. PMID:30471425
A HS6ST2 gene variant associated with X-linked intellectual disability and severe myopia in two male twins. PMID:30471091
Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer. PMID:30470719
Protocadherin-1 is essential for cell entry by New World hantaviruses. PMID:30464266
Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium. PMID:30464253
Integration of transcriptome and proteome profiles in glioblastoma: looking for the missing link. PMID:30463513
Tissue-Based Mapping of the Fathead Minnow (Pimephales promelas) Transcriptome and Proteome. PMID:30459712
Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson's Disease and Synucleinopathies. PMID:30459551
CAARS: comparative assembly and annotation of RNA-Seq data. PMID:30452539
Characterization of the F-box Proteins FBXW2 and FBXL14 in the Initiation of Bone Regeneration in Transplants given to Nude Mice. PMID:30450135
Methylation-Based Classification of Cervical Squamous Cell Carcinoma into Two New Subclasses Differing in Immune-Related Gene Expression. PMID:30445744
The expression signature of cancer-associated KRAB-ZNF factors identified in TCGA pan-cancer transcriptomic data. PMID:30444046
Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes. PMID:30443895
Gene expression profile of muscle adaptation to high-intensity intermittent exercise training in young men. PMID:30429512
Identification of TEX101-associated Proteins Through Proteomic Measurement of Human Spermatozoa Homozygous for the Missense Variant rs35033974. PMID:30429210
funcExplorer: a tool for fast data-driven functional characterisation of high-throughput expression data. PMID:30428831
The Body-wide Transcriptome Landscape of Disease Models. PMID:30428375
Diabetes in Pregnancy and MicroRNAs: Promises and Limitations in Their Clinical Application. PMID:30424584
miRNA Mediated Noise Making of 3'UTR Mutations in Cancer. PMID:30424545
UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma. PMID:30420903
PTMiner: Localization and Quality Control of Protein Modifications Detected in an Open Search and Its Application to Comprehensive Post-translational Modification Characterization in Human Proteome. PMID:30420486
Bi-allelic POLR3A Loss-of-Function Variants Cause Autosomal-Recessive Wiedemann-Rautenstrauch Syndrome. PMID:30414627
Identifying a Novel Biomarker TOP2A of Clear Cell Renal Cell Carcinoma (ccRCC) Associated with Smoking by Co-Expression Network Analysis. PMID:30410595
Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs. PMID:30410047
Up-regulation of collagen proteins in colorectal liver metastasis compared with normal liver tissue. PMID:30409905
Identification of Core Biomarkers Associated with Outcome in Glioma: Evidence from Bioinformatics Analysis. PMID:30405856
A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer. PMID:30405805
Multivalent activation of GLP-1 and sulfonylurea receptors modulates β-cell second-messenger signaling and insulin secretion. PMID:30404557
Exploring Seipin: From Biochemistry to Bioinformatics Predictions. PMID:30402103
Regulation of Connexin32 by ephrin receptors and T-cell protein-tyrosine phosphatase. PMID:30401746
MitoMiner v4.0: an updated database of mitochondrial localization evidence, phenotypes and diseases. PMID:30398659
Perturbations of Neuron-Restrictive Silencing Factor Modulate Corticotropin-Releasing Hormone Gene Expression in the Human Cell Line BeWo. PMID:30397598
Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism. PMID:30397099
Host Peptidic Hormones Affecting Bacterial Biofilm Formation and Virulence. PMID:30396172
Comparative transcriptomics identifies genes differentially expressed in the intestine of a new fast-growing strain of common carp with higher unsaturated fatty acid content in muscle. PMID:30395585
Vitamin D stimulates multiple microRNAs to inhibit CRH and other pro-labor genes in human placenta. PMID:30395535
Integrated Epigenetic Mapping of Human and Mouse Salivary Gene Regulation. PMID:30392435
Laser capture microdissection-targeted mass spectrometry: a method for multiplexed protein quantification within individual layers of the cerebral cortex. PMID:30390066
X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family. PMID:30389958
Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects. PMID:30388400
HAVCR1 expression might be a novel prognostic factor for gastric cancer. PMID:30388143
Proteomic profiling of liver tissue from the mdx-4cv mouse model of Duchenne muscular dystrophy. PMID:30386187
Detection of Shared Balancing Selection in the Absence of Trans-Species Polymorphism. PMID:30380122
From Single Level Analysis to Multi-Omics Integrative Approaches: A Powerful Strategy towards the Precision Oncology. PMID:30373182
Functional analysis of mammalian phospholipase D enzymes. PMID:30369483
CamurWeb: a classification software and a large knowledge base for gene expression data of cancer. PMID:30367574
Effect of equiaxial cyclic strain on cardiomyogenic induction in mesenchymal stem cells. PMID:30367393
Antiviral activity of the mineralocorticoid receptor NR3C2 against Herpes simplex virus Type 1 (HSV-1) infection. PMID:30367157
Targeted Analysis of Serum Proteins Encoded at Known Inflammatory Bowel Disease Risk Loci. PMID:30358838
BitterDB: taste ligands and receptors database in 2019. PMID:30357384
Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth. PMID:30356100
Druggability of Coronary Artery Disease Risk Loci. PMID:30354342
ACTA1 Novel Likely Pathogenic Variant in a Family With Dilated Cardiomyopathy. PMID:30354303
Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer. PMID:30349298
TissueEnrich: Tissue-specific gene enrichment analysis. PMID:30346488
Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions. PMID:30345971
Missense Mutations of the Pro65 Residue of PCGF2 Cause a Recognizable Syndrome Associated with Craniofacial, Neurological, Cardiovascular, and Skeletal Features. PMID:30343942
Aberrant PRDM9 expression impacts the pan-cancer genomic landscape. PMID:30341163
Evaluation of PACE4 isoforms as biomarkers in thyroid cancer. PMID:30340539
Novel MXD4-NUTM1 fusion transcript identified in primary ovarian undifferentiated small round cell sarcoma. PMID:30338611
IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line. PMID:30338032
Rapamycin in ischemic stroke: Old drug, new tricks? PMID:30334673
Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs. PMID:30333515
A Comparative Assessment of Human and Chimpanzee iPSC-derived Cardiomyocytes with Primary Heart Tissues. PMID:30333510
LncBook: a curated knowledgebase of human long non-coding RNAs. PMID:30329098
Interleukin 30 to Interleukin 40. PMID:30328794
Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients. PMID:30323977
ESS: A Tool for Genome-Scale Quantification of Essentiality Score for Reaction/Genes in Constraint-Based Modeling. PMID:30323767
Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma. PMID:30322894
Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs. PMID:30319685
The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease. PMID:30319631
Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts. PMID:30319613
Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins. PMID:30316580
Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN-FOS at composite DNA sites. PMID:30315111
Human Testis Extracellular Matrix Enhances Human Spermatogonial Stem Cell Survival In Vitro. PMID:30311859
Shortening of apparent transverse relaxation time of inorganic phosphate as a breast cancer biomarker. PMID:30311703
Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization. PMID:30309985
Comparison of breast cancer metastasis models reveals a possible mechanism of tumor aggressiveness. PMID:30305609
Human DREF/ZBED1 is a nuclear protein widely expressed in multiple cell types derived from all three primary germ layers. PMID:30304065
Histone Deacetylase Inhibition Has Targeted Clinical Benefit in ARID1A-Mutated Advanced Urothelial Carcinoma. PMID:30301863
Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations. PMID:30301787
Enhanced validation of antibodies for research applications. PMID:30297845
Haplosaurus computes protein haplotypes for use in precision drug design. PMID:30297836
Impact of chemotactic factors and receptors on the cancer immune infiltrate: a bioinformatics study revealing homogeneity and heterogeneity among patient cohorts. PMID:30288345
Prediction of gene regulatory enhancers across species reveals evolutionarily conserved sequence properties. PMID:30286077
Autoantibodies Against Perilipin 1 as a Cause of Acquired Generalized Lipodystrophy. PMID:30283460
Guidance Molecules in Vascular Smooth Muscle. PMID:30283356
Colonic epithelial miR-31 associates with the development of Crohn's phenotypes. PMID:30282822
A non-coding region near Follistatin controls head colour polymorphism in the Gouldian finch. PMID:30282656
A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein. PMID:30279450
psichomics: graphical application for alternative splicing quantification and analysis. PMID:30277515
Application of weighted gene co-expression network analysis to identify key modules and hub genes in oral squamous cell carcinoma tumorigenesis. PMID:30275705
Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease. PMID:30275566
Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline. PMID:30275468
Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma. PMID:30272346
Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research. PMID:30271982
Launching the C-HPP neXt-CP50 Pilot Project for Functional Characterization of Identified Proteins with No Known Function. PMID:30269496
Short Leucine-Rich Proteoglycans Modulate Complement Activity and Increase Killing of the Respiratory Pathogen Moraxella catarrhalis. PMID:30266767
Structure and Protein Interaction-Based Gene Ontology Annotations Reveal Likely Functions of Uncharacterized Proteins on Human Chromosome 17. PMID:30265558
A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder. PMID:30262571
Epigenetic Study in Parkinson's Disease: A Pilot Analysis of DNA Methylation in Candidate Genes in Brain. PMID:30261625
A short isoform of ATG7 fails to lipidate LC3/GABARAP. PMID:30258106
The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. PMID:30251625
A meta-analysis and bioinformatics exploration of the diagnostic value and molecular mechanism of miR-193a-5p in lung cancer. PMID:30250529
Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes. PMID:30250408
Optimisation of a serum albumin removal protocol for use in a proteomic study to identify the protein biomarkers for silent gastric ulceration in horses. PMID:30250392
A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach. PMID:30249792
Vimentin Diversity in Health and Disease. PMID:30248895
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome. PMID:30242179
Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer. PMID:30241606
Functional and phylogenetic characterization of noncanonical vitamin B12-binding proteins in zebrafish suggests involvement in cobalamin transport. PMID:30237171
Emerging Developments in Microbiome and Microglia Research: Implications for Neurodevelopmental Disorders. PMID:30233586
Absence of AIF1L contributes to cell migration and a poor prognosis of breast cancer. PMID:30233209
SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer. PMID:30231985
Large-scale investigation of the reasons why potentially important genes are ignored. PMID:30226837
Translational molecular imaging in exocrine pancreatic cancer. PMID:30225616
sox9b is required in cardiomyocytes for cardiac morphogenesis and function. PMID:30224706
Downregulation of FOXK2 is associated with poor prognosis in patients with gastric cancer. PMID:30221666
Frequency and signature of somatic variants in 1461 human brain exomes. PMID:30214067
Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation. PMID:30214039
ADAP1 limits neonatal cardiomyocyte hypertrophy by reducing integrin cell surface expression. PMID:30206251
A Computational Method for Classifying Different Human Tissues with Quantitatively Tissue-Specific Expressed Genes. PMID:30205473
Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD. PMID:30202070
Cell type-resolved human lung lipidome reveals cellular cooperation in lung function. PMID:30194354
Neuronal pentraxin receptor-1 is a new cerebrospinal fluid biomarker of Alzheimer's disease progression. PMID:30191060
xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction. PMID:30190786
Cross-tissue eQTL enrichment of associations in schizophrenia. PMID:30188921
The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer. PMID:30188895
Integrated measurement of intracellular proteins and transcripts in single cells. PMID:30178802
Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage. PMID:30175270
Study of mitotic chromatin supports a model of bookmarking by histone modifications and reveals nucleosome deposition patterns. PMID:30166406
Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney. PMID:30166318
Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer. PMID:30161001
Selenium-Encoded Isotopic Signature Targeted Profiling. PMID:30159393
Anti-ARHGAP26 Autoantibodies Are Associated With Isolated Cognitive Impairment. PMID:30158896
Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP. PMID:30158653
Region-Resolved Quantitative Proteome Profiling Reveals Molecular Dynamics Associated With Chronic Pain in the PNS and Spinal Cord. PMID:30154697
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes. PMID:30154505
MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology. PMID:30153342
Exploring the Role of Fallopian Ciliated Cells in the Pathogenesis of High-Grade Serous Ovarian Cancer. PMID:30149579
Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ. PMID:30135298
DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride. PMID:30132517
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. PMID:30125269
Chronic Adrenergic Signaling Causes Abnormal RNA Expression of Proliferative Genes in Fetal Sheep Islets. PMID:30124804
Prediagnostic circulating markers of inflammation and risk of oesophageal adenocarcinoma: a study within the National Cancer Institute Cohort Consortium. PMID:30121626
Na/K-ATPase Y260 Phosphorylation-mediated Src Regulation in Control of Aerobic Glycolysis and Tumor Growth. PMID:30120256
Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma. PMID:30119675
Identification of non-mutated neoantigens presented by TAP-deficient tumors. PMID:30115740
Systems level expression correlation of Ras GTPase regulators. PMID:30111366
Identification of pathways and genes associated with cerebral palsy. PMID:30109564
Approaches to target tractability assessment - a practical perspective. PMID:30108951
Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins. PMID:30108415
Proteomics: Clinical and research applications in respiratory diseases. PMID:30105802
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms. PMID:30101371
Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project. PMID:30099871
Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies. PMID:30097533
Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers. PMID:30090875
Proteomic distinction of renal oncocytomas and chromophobe renal cell carcinomas. PMID:30087584
CTCF maintains regulatory homeostasis of cancer pathways. PMID:30086769
FBXW7: a critical tumor suppressor of human cancers. PMID:30086763
Antibody validation: a view from the mountains. PMID:30086383
Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum. PMID:30086131
On the problem of confounders in modeling gene expression. PMID:30084962
A tissue-based draft map of the murine MHC class I immunopeptidome. PMID:30084848
Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours. PMID:30082739
Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor. PMID:30082484
A secretome profile indicative of oleate-induced proliferation of HepG2 hepatocellular carcinoma cells. PMID:30076294
ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport. PMID:30076131
Smoking-induced iron dysregulation in the lung. PMID:30075191
Bi-allelic Recessive Loss-of-Function Variants in FANCM Cause Non-obstructive Azoospermia. PMID:30075111
Familial Cancer Variant Prioritization Pipeline version 2 (FCVPPv2) applied to a papillary thyroid cancer family. PMID:30072699
Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma. PMID:30072578
Co-regulatory networks of human serum proteins link genetics to disease. PMID:30072576
Mechanistic Insights into CpG DNA and IL-15 Synergy in Promoting B Cell Chronic Lymphocytic Leukemia Clonal Expansion. PMID:30068596
Prognostic values of the inhibitor of DNA‑binding family members in breast cancer. PMID:30066902
Bacterial Outer Membrane Vesicles Induce Vitronectin Release Into the Bronchoalveolar Space Conferring Protection From Complement-Mediated Killing. PMID:30061873
Amelioration of Diabetic Nephropathy Using a Retinoic Acid Receptor β2 Agonist. PMID:30054312
BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery. PMID:30053270
Characterization of FGD5 Expression in Primary Breast Cancers and Lymph Node Metastases. PMID:30052477
Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts. PMID:30052023
Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways. PMID:30050127
Inhibitors of lysosomal function or serum starvation in control or LAMP2 deficient cells do not modify the cellular levels of Parkinson disease-associated DJ-1/PARK 7 protein. PMID:30048497
Identification of integrin drug targets for 17 solid tumor types. PMID:30046394
Liver-enriched Genes are Associated with the Prognosis of Patients with Hepatocellular Carcinoma. PMID:30046116
Epigenetic Variability Confounds Transcriptome but Not Proteome Profiling for Coexpression-based Gene Function Prediction. PMID:30042154
Age-Related Differential Structural and Transcriptomic Responses in the Hypertensive Heart. PMID:30038575
Appetite, Metabolism and Hormonal Regulation in Normal Ageing and Dementia. PMID:30036957
Transferrin receptor 1 in cancer: a new sight for cancer therapy. PMID:30034931
Targeting Pim Kinases and DAPK3 to Control Hypertension. PMID:30033129
VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival. PMID:30027561
Chemical and genetic control of IFNγ-induced MHCII expression. PMID:30021835
Alzheimer disease pathology and the cerebrospinal fluid proteome. PMID:30021611
A Universal Live Cell Barcoding-Platform for Multiplexed Human Single Cell Analysis. PMID:30018331
Downregulation of miR‑486‑5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing. PMID:30015845
Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk. PMID:30013180
A meta-analysis of transcriptome datasets characterizes malignant transformation from melanocytes and nevi to melanoma. PMID:30008882
Functional characteristics of novel pancreatic Pax6 regulatory elements. PMID:30007277
Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers. PMID:29997511
Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21. PMID:29997282
Lack of evidence for a causal role of CALR3 in monogenic cardiomyopathy. PMID:29988065
Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma. PMID:29987839
Silencing NIK potentiates anti-VEGF therapy in a novel 3D model of colorectal cancer angiogenesis. PMID:29983872
A Screening Rule for ℓ1-Regularized Ising Model Estimation. PMID:29983538
Loose ends: almost one in five human genes still have unresolved coding status. PMID:29982784
ABRF Proteome Informatics Research Group (iPRG) 2016 Study: Inferring Proteoforms from Bottom-up Proteomics Data. PMID:29977167
Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer. PMID:29975776
MicroRNA interactome analysis predicts post-transcriptional regulation of ADRB2 and PPP3R1 in the hypercholesterolemic myocardium. PMID:29973623
Actionable Metabolic Pathways in Heart Failure and Cancer-Lessons From Cancer Cell Metabolism. PMID:29971237
Differential Integration of Transcriptome and Proteome Identifies Pan-Cancer Prognostic Biomarkers. PMID:29971090
Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15. PMID:29970016
Enteric Species F Human Adenoviruses use Laminin-Binding Integrins as Co-Receptors for Infection of Ht-29 Cells. PMID:29968781
Six novel susceptibility loci for coronary artery disease and cerebral infarction identified by longitudinal exome-wide association studies in a Japanese population. PMID:29963304
Genome sequencing as a first-line genetic test in familial dilated cardiomyopathy. PMID:29961767
xMD-miRNA-seq to generate near in vivo miRNA expression estimates in colon epithelial cells. PMID:29955168
Quantitative Proteomic Analysis Identifies AHNAK (Neuroblast Differentiation-associated Protein AHNAK) as a Novel Candidate Biomarker for Bladder Urothelial Carcinoma Diagnosis by Liquid-based Cytology. PMID:29950347
NF-kappaB Regulates Redox Status in Breast Cancer Subtypes. PMID:29949949
Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency. PMID:29949756
Quantification of Inflammasome Adaptor Protein ASC in Biological Samples by Multiple-Reaction Monitoring Mass Spectrometry. PMID:29948504
Presence of growth/differentiation factor-15 cytokine in human follicular fluid, granulosa cells, and oocytes. PMID:29948426
Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population. PMID:29945935
The arrhythmogenic cardiomyopathy-specific coding and non-coding transcriptome in human cardiac stromal cells. PMID:29940860
TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis. PMID:29940807
Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources. PMID:29931155
Regulation of Gastric Lgr5+ve Cell Homeostasis by Bone Morphogenetic Protein (BMP) Signaling and Inflammatory Stimuli. PMID:29930977
Molecular insights into cardiomyopathies associated with desmin (DES) mutations. PMID:29926427
Loss of the basic helix-loop-helix transcription factor Bhlhe41 induces cell death and impairs neurite outgrowth in Neuro2a cells. PMID:29926321
Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors. PMID:29925909
Circulating MicroRNAs: a Potential Biomarker for Cardiac Damage, Inflammatory Response, and Left Ventricular Function Recovery in Pediatric Viral Myocarditis. PMID:29916103
Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond-like syndrome. PMID:29914977
Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review. PMID:29910734
Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas. PMID:29909548
Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development. PMID:29907769
FOXA2 promotes the proliferation, migration and invasion, and epithelial mesenchymal transition in colon cancer. PMID:29896233
A homozygous FANCM frameshift pathogenic variant causes male infertility. PMID:29895858
Brain Cell Type Specific Gene Expression and Co-expression Network Architectures. PMID:29892006
TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer. PMID:29891505
A Computational Approach for Prioritizing Selection of Therapies Targeting Drug Resistant Variation in Anaplastic Lymphoma Kinase. PMID:29888064
A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits. PMID:29887380
Papillomavirus E2 protein is regulated by specific fibroblast growth factor receptors. PMID:29885490
Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies. PMID:29884306
Re-Evaluating E-Cadherin and β-Catenin: A Pan-Cancer Proteomic Approach with an Emphasis on Breast Cancer. PMID:29879416
The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses. PMID:29875205
Changing Trends in Computational Drug Repositioning. PMID:29874824
Precision histology: how deep learning is poised to revitalize histomorphology for personalized cancer care. PMID:29872706
The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment. PMID:29872573
GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. PMID:29872392
A candidate gene identification strategy utilizing mouse to human big-data mining: "3R-tenet" in COPD genetic research. PMID:29871630
Comparison of tumor related signaling pathways with known compounds to determine potential agents for lung adenocarcinoma. PMID:29870138
Meta-Analysis of Maternal and Fetal Transcriptomic Data Elucidates the Role of Adaptive and Innate Immunity in Preterm Birth. PMID:29867970
Deciphering the Pathological Role of Staphylococcal α-Toxin and Panton-Valentine Leukocidin Using a Novel Ex Vivo Human Skin Model. PMID:29867940
Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function. PMID:29867550
CharmeRT: Boosting Peptide Identifications by Chimeric Spectra Identification and Retention Time Prediction. PMID:29863353
Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites. PMID:29858488
Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs. PMID:29858229
TRAPPC11 and GOSR2 mutations associate with hypoglycosylation of α-dystroglycan and muscular dystrophy. PMID:29855340
Parenclitic networks for predicting ovarian cancer. PMID:29854310
Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1. PMID:29853471
Basement Membranes in Development and Disease. PMID:29853176
Severe neurocognitive and growth disorders due to variation in THOC2, an essential component of nuclear mRNA export machinery. PMID:29851191
CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer. PMID:29849821
A targeted in situ hybridization screen identifies putative seminal fluid proteins in a simultaneously hermaphroditic flatworm. PMID:29848299
miRNA-106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation. PMID:29845714
PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma. PMID:29844863
Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner. PMID:29844359
Increased GOLM1 Expression Independently Predicts Unfavorable Overall Survival and Recurrence-Free Survival in Lung Adenocarcinoma. PMID:29843532
Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. PMID:29808012
Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain. PMID:29806693
Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. PMID:29804876
Human microRNAs preferentially target genes with intermediate levels of expression and its formation by mammalian evolution. PMID:29795674
A Single-Cell Transcriptome Atlas of the Mouse Glomerulus. PMID:29794128
Casein kinase 1α: biological mechanisms and theranostic potential. PMID:29793495
A de novo KCNA1 Mutation in a Patient with Tetany and Hypomagnesemia. PMID:29791908
A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. PMID:29791858
rbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences. PMID:29789616
DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different. PMID:29788379
Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung. PMID:29788210
Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells. PMID:29786565
A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility. PMID:29786094
Systematic interrogation of diverse Omic data reveals interpretable, robust, and generalizable transcriptomic features of clinically successful therapeutic targets. PMID:29782487
C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases. PMID:29775578
The landscape of the non-canonical RNA-binding site of Gemin5 unveils a feedback loop counteracting the negative effect on translation. PMID:29771365
The importance of a halotyrosine dehalogenase for Drosophila fertility. PMID:29764939
Moving the Cellular Peptidome by Transporters. PMID:29761100
NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes. PMID:29759984
Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study. PMID:29755980
Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates. PMID:29752409
Assessing the functional association of intronic miRNAs with their host genes. PMID:29752351
Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity. PMID:29752062
Oncogenic role of miR‑183‑5p in lung adenocarcinoma: A comprehensive study of qPCR, in vitro experiments and bioinformatic analysis. PMID:29749535
NCS-1 is a regulator of calcium signaling in health and disease. PMID:29746899
Aberrant S100A16 expression might be an independent prognostic indicator of unfavorable survival in non-small cell lung adenocarcinoma. PMID:29746588
Automated transition analysis of activated gene regulation during diauxic nutrient shift in Escherichia coli and adipocyte differentiation in mouse cells. PMID:29745848
Inhibitory Effects of HIV-2 Vpx on Replication of HIV-1. PMID:29743354
NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland. PMID:29742982
CXCL12/CXCR4 Signaling Enhances Human PSC-Derived Hematopoietic Progenitor Function and Overcomes Early In Vivo Transplantation Failure. PMID:29742393
Transcellular transport of cobalamin in aortic endothelial cells. PMID:29741927
A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis. PMID:29736411
Highly multiplexed single-cell in situ RNA and DNA analysis with bioorthogonal cleavable fluorescent oligonucleotides. PMID:29732074
Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3. PMID:29730990
Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells. PMID:29729928
PregOMICS-Leveraging systems biology and bioinformatics for drug repurposing in maternal-child health. PMID:29726581
Improving the Efficiency of Vγ9Vδ2 T-Cell Immunotherapy in Cancer. PMID:29725332
Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer. PMID:29723302
Insulin acts as a repressive factor to inhibit the ability of PAR2 to induce islet cell transdifferentiation. PMID:29723131
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. PMID:29719619
Ancient Nuclear Receptor VDR With New Functions: Microbiome and Inflammation. PMID:29718408
Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis. PMID:29718219
Gestational Hypoxia and Developmental Plasticity. PMID:29717932
Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn. PMID:29717160
Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells. PMID:29712574
Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction. PMID:29702679
Impact of miR-140 Deficiency on Non-Alcoholic Fatty Liver Disease. PMID:29701903
The Emerging Immunogenetic Architecture of Schizophrenia. PMID:29701842
Interferon induced protein 35 exacerbates H5N1 influenza disease through the expression of IL-12p40 homodimer. PMID:29698474
Single-Cell in Situ RNA Analysis With Switchable Fluorescent Oligonucleotides. PMID:29696143
Profiling plasma extracellular vesicle by pluronic block-copolymer based enrichment method unveils features associated with breast cancer aggression, metastasis and invasion. PMID:29696079
Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions. PMID:29695497
Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington's Disease. PMID:29694882
Community-driven roadmap for integrated disease maps. PMID:29688273
Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies. PMID:29682908
Pregnancy-associated diamine oxidase originates from extravillous trophoblasts and is decreased in early-onset preeclampsia. PMID:29679053
3-Substituted 1,5-Diaryl-1 H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 1: Synthesis and Pharmacology. PMID:29678105
Cardiomyocytes have mosaic patterns of protein expression. PMID:29677652
Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall-King Hypothesis. PMID:29675414
Cystic fibrosis-related diabetes is caused by islet loss and inflammation. PMID:29669939
Glucose-regulated protein 78 is essential for cardiac myocyte survival. PMID:29666470
A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders. PMID:29665782
Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment. PMID:29663285
Computation and application of tissue-specific gene set weights. PMID:29659714
Mapping the tumour human leukocyte antigen (HLA) ligandome by mass spectrometry. PMID:29658117
Efficacy and Mechanism of Antitumor Activity of an Antibody Targeting Transferrin Receptor 1 in Mouse Models of Human Multiple Myeloma. PMID:29654211
A meta-analysis of public microarray data identifies biological regulatory networks in Parkinson's disease. PMID:29653596
Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes. PMID:29650774
Identification of Significant Gene Signatures and Prognostic Biomarkers for Patients With Cervical Cancer by Integrated Bioinformatic Methods. PMID:29642758
Wnt Signaling in Thyroid Homeostasis and Carcinogenesis. PMID:29642644
A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. PMID:29638227
The latent geometry of the human protein interaction network. PMID:29635317
Inhibition of DNA methyltransferase leads to increased genomic 5-hydroxymethylcytosine levels in hematopoietic cells. PMID:29632811
Alpha-v-containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP. PMID:29632205
Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation. PMID:29632189
The KASH-containing isoform of Nesprin1 giant associates with ciliary rootlets of ependymal cells. PMID:29630990
Plasma mSEPT9: A Novel Circulating Cell-free DNA-Based Epigenetic Biomarker to Diagnose Hepatocellular Carcinoma. PMID:29627389
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. PMID:29625592
A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development. PMID:29625070
The impact of tumor receptor heterogeneity on the response to anti-angiogenic cancer treatment. PMID:29623971
Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis. PMID:29623276
On the Role of Store-Operated Calcium Entry in Acute and Chronic Neurodegenerative Diseases. PMID:29623030
Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins. PMID:29620521
Peptide Sharing Between Viruses and DLX Proteins: A Potential Cross-Reactivity Pathway to Neuropsychiatric Disorders. PMID:29618965
A reference peptide database for proteome quantification based on experimental mass spectrum response curves. PMID:29617941
TISSUES 2.0: an integrative web resource on mammalian tissue expression. PMID:29617745
Mining the Human Tissue Proteome for Protein Citrullination. PMID:29610271
Homo sapiens-Specific Binding Site Variants within Brain Exclusive Enhancers Are Subject to Accelerated Divergence across Human Population. PMID:29608725
Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes. PMID:29599435
Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer. PMID:29596465
Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity. PMID:29589874
HLA and proteasome expression body map. PMID:29587858
Glycosyltransferase genes that cause monogenic congenital disorders of glycosylation are distinct from glycosyltransferase genes associated with complex diseases. PMID:29579191
Specification of trophoblast from embryonic stem cells exposed to BMP4. PMID:29579154
Wharton's Jelly Mesenchymal Stromal Cells Support the Expansion of Cord Blood-derived CD34+ Cells Mimicking a Hematopoietic Niche in a Direct Cell-cell Contact Culture System. PMID:29562783
A comprehensive catalog of predicted functional upstream open reading frames in humans. PMID:29562350
Gastric cancer biomarkers; A systems biology approach. PMID:29556568
The tubulin code in neuronal polarity. PMID:29554585
Cladribine treatment of multiple sclerosis is associated with depletion of memory B cells. PMID:29550884
Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes. PMID:29550255
Heterodimer Binding Scaffolds Recognition via the Analysis of Kinetically Hot Residues. PMID:29547506
Ensemble Methods with Voting Protocols Exhibit Superior Performance for Predicting Cancer Clinical Endpoints and Providing More Complete Coverage of Disease-Related Genes. PMID:29546047
Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity. PMID:29545808
Coordinated transcription of ANRIL and P16 genes is silenced by P16 DNA methylation. PMID:29545723
Identification of prefrontal cortex protein alterations in Alzheimer's disease. PMID:29541381
Transcriptome-derived stromal and immune scores infer clinical outcomes of patients with cancer. PMID:29541203
Global quantitative analysis of the human brain proteome in Alzheimer's and Parkinson's Disease. PMID:29533394
CoA synthase regulates mitotic fidelity via CBP-mediated acetylation. PMID:29531224
Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins. PMID:29530979
Is folic acid safe for non-muscle-invasive bladder cancer patients? An evidence-based cohort study. PMID:29529165
Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy. PMID:29529088
A proteomic landscape of diffuse-type gastric cancer. PMID:29520031
CMS-dependent prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer. PMID:29518181
The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis. PMID:29515971
Genome-wide transcriptome analysis identifies alternative splicing regulatory network and key splicing factors in mouse and human psoriasis. PMID:29515135
Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. PMID:29511213
Current applications of antibody microarrays. PMID:29507545
MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. PMID:29507340
Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. PMID:29507296
Rare variants in axonogenesis genes connect three families with sound-color synesthesia. PMID:29507195
Petri net-based prediction of therapeutic targets that recover abnormally phosphorylated proteins in muscle atrophy. PMID:29506508
A case of an infant suspected as IMAGE syndrome who were finally diagnosed with MIRAGE syndrome by targeted Mendelian exome sequencing. PMID:29506479
Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow. PMID:29500430
Carbonic Anhydrases: Role in pH Control and Cancer. PMID:29495652
Change of Title: Microarrays Becomes High-Throughput. PMID:29485608
Prognostic and predictive value of HURP in non‑small cell lung cancer. PMID:29484418
Ten hub genes associated with progression and prognosis of pancreatic carcinoma identified by co-expression analysis. PMID:29483831
The regulation of glycogenolysis in the brain. PMID:29483194
How Omics Data Can Be Used in Nephrology. PMID:29478865
Loss of Function of the Nuclear Receptor NR2F2, Encoding COUP-TF2, Causes Testis Development and Cardiac Defects in 46,XX Children. PMID:29478779
Recently Evolved Tumor Suppressor Transcript TP73-AS1 Functions as Sponge of Human-Specific miR-941. PMID:29474580
CGB5 expression is independently associated with poor overall survival and recurrence-free survival in patients with advanced gastric cancer. PMID:29473345
Unexplored therapeutic opportunities in the human genome. PMID:29472638
Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions. PMID:29472485
Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish. PMID:29468257
Adhesion GPCRs in Kidney Development and Disease. PMID:29468160
Identification, isolation and characterization of human LGR5-positive colon adenoma cells. PMID:29467240
Positive zip coding in small protein translocation. PMID:29462795
The altered expression of perineuronal net elements during neural differentiation. PMID:29456557
Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides. PMID:29453283
GPCRs in context: sexual dimorphism in the cardiovascular system. PMID:29451687
Access to the CNS: Biomarker Strategies for Dopaminergic Treatments. PMID:29450650
An in silico argument for mitochondrial microRNA as a determinant of primary non function in liver transplantation. PMID:29449571
Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density. PMID:29444691
How many human proteoforms are there? PMID:29443976
Transcriptome analysis reveals TMPRSS6 isoforms with distinct functionalities. PMID:29441715
Autophagy and Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Implications. PMID:29441009
Diurnal transcriptome atlas of a primate across major neural and peripheral tissues. PMID:29439024
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer. PMID:29436393
The PHD1 oxygen sensor in health and disease. PMID:29435987
Gadd45β silencing impaired viability and metastatic phenotypes in cholangiocarcinoma cells by modulating the EMT pathway. PMID:29435034
Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses. PMID:29432180
Tumor microenvironment heterogeneity: challenges and opportunities. PMID:29430386
GeneGini: Assessment via the Gini Coefficient of Reference "Housekeeping" Genes and Diverse Human Transporter Expression Profiles. PMID:29428416
Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations. PMID:29425227
Rce1: mechanism and inhibition. PMID:29424242
Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance. PMID:29423065
MELK expression correlates with tumor mitotic activity but is not required for cancer growth. PMID:29417930
HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells. PMID:29417297
Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction. PMID:29416706
LanCL1 protects prostate cancer cells from oxidative stress via suppression of JNK pathway. PMID:29416001
HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas. PMID:29409830
In Vitro Modeling of Leucine-Rich Repeat Kinase 2 G2019S-Mediated Parkinson's Disease Pathology. PMID:29402177
RNA-protein interaction detection in living cells. PMID:29400715
The tumour glyco-code as a novel immune checkpoint for immunotherapy. PMID:29398707
Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome. PMID:29395072
Cooperation between ETS variant 2 and Jumonji domain‑containing 2 histone demethylases. PMID:29393482
RNentropy: an entropy-based tool for the detection of significant variation of gene expression across multiple RNA-Seq experiments. PMID:29390085
The Ewing Sarcoma Secretome and Its Response to Activation of Wnt/beta-catenin Signaling. PMID:29386236
Expression profiles of Sox transcription factors within the postnatal rodent testes. PMID:29383560
Hypoxia-inducible factor-1α promotes cell survival during ammonia stress response in ovarian cancer stem-like cells. PMID:29383096
Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer. PMID:29382334
Single-Nucleotide Variations of the Human Nuclear Hormone Receptor Genes in 60,000 Individuals. PMID:29379896
Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo. PMID:29374152
Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. PMID:29374058
Proteomics Profiling of CLL Versus Healthy B-cells Identifies Putative Therapeutic Targets and a Subtype-independent Signature of Spliceosome Dysregulation. PMID:29367434
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. PMID:29364867
The diamond anniversary of tissue transglutaminase: a protein of many talents. PMID:29362136
Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9. PMID:29361803
A branching morphogenesis program governs embryonic growth of the thyroid gland. PMID:29361553
The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability. PMID:29361176
Contribution of Adipose Tissue to Development of Cancer. PMID:29357128
Regeneration in distantly related species: common strategies and pathways. PMID:29354283
LIMK/cofilin pathway and Slingshot are implicated in human colorectal cancer progression and chemoresistance. PMID:29352327
Membranous nephropathy associated with pregnancy: an anti-phospholipase A2 receptor antibody-positive case report. PMID:29349731
Identification of novel diagnostic biomarkers for thyroid carcinoma. PMID:29340074
Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms. PMID:29339080
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand. PMID:29337137
As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. PMID:29337136
Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells. PMID:29334988
Dynamic changes in copper homeostasis and post-transcriptional regulation of Atp7a during myogenic differentiation. PMID:29333545
Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR. PMID:29330362
Modelling the structure of a ceRNA-theoretical, bipartite microRNA-mRNA interaction network regulating intestinal epithelial cellular pathways using R programming. PMID:29329594
Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase. PMID:29326160
Defining tissue proteomes by systematic literature review. PMID:29323144
AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. PMID:29321668
Voltage-gated sodium channels: (NaV )igating the field to determine their contribution to visceral nociception. PMID:29318638
A genome-wide association study identifies only two ancestry specific variants associated with spontaneous preterm birth. PMID:29317701
The polarity protein Angiomotin p130 controls dendritic spine maturation. PMID:29317530
Identification of Transposable Elements Contributing to Tissue-Specific Expression of Long Non-Coding RNAs. PMID:29315213
Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome. PMID:29309034
Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents. PMID:29305616
POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain. PMID:29305536
Integration of multiple networks and pathways identifies cancer driver genes in pan-cancer analysis. PMID:29304754
Amphioxus SYCP1: a case of retrogene replacement and co-option of regulatory elements adjacent to the ParaHox cluster. PMID:29297095
Resistance to receptor-blocking therapies primes tumors as targets for HER3-homing nanobiologics. PMID:29288681
Comparative Proteomics Analysis of Urine Reveals Down-Regulation of Acute Phase Response Signaling and LXR/RXR Activation Pathways in Prostate Cancer. PMID:29286311
Using single-cell multiple omics approaches to resolve tumor heterogeneity. PMID:29285690
DE-kupl: exhaustive capture of biological variation in RNA-seq data through k-mer decomposition. PMID:29284518
Expitope 2.0: a tool to assess immunotherapeutic antigens for their potential cross-reactivity against naturally expressed proteins in human tissues. PMID:29282079
Cancer transcriptome profiling at the juncture of clinical translation. PMID:29279605
Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes. PMID:29275860
De novo large rare copy-number variations contribute to conotruncal heart disease in Chinese patients. PMID:29263819
Systems-epigenomics inference of transcription factor activity implicates aryl-hydrocarbon-receptor inactivation as a key event in lung cancer development. PMID:29262847
Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis. PMID:29262532
Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells. PMID:29259115
Evolutionary expansion of DNA hypomethylation in the mammalian germline genome. PMID:29259021
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. PMID:29257953
High expression of FLT3 is a risk factor in leukemia. PMID:29257272
Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α'. PMID:29236079
SLC9B1 methylation predicts fetal intolerance of labor. PMID:29235940
The landscape of miRNA editing in animals and its impact on miRNA biogenesis and targeting. PMID:29233923
Whole-Exome Sequencing Identifies a de novo AHDC1 Mutation in a Colombian Patient with Xia-Gibbs Syndrome. PMID:29230160
Identification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach. PMID:29229936
Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer. PMID:29229604
Comparative transcriptomic analysis of human placentae at term and preterm delivery. PMID:29228154
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain. PMID:29227469
Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines. PMID:29226804
Whole-exome sequencing for detecting inborn errors of immunity: overview and perspectives. PMID:29225788
Transcription and Remodeling Produce Asymmetrically Unwrapped Nucleosomal Intermediates. PMID:29225036
Genome-Wide Analysis of Barrett's Adenocarcinoma. A First Step Towards Identifying Patients at Risk and Developing Therapeutic Paths. PMID:29223109
Deciphering transcriptional regulation in human embryonic stem cells specified towards a trophoblast fate. PMID:29222466
Cellular FLIP long isoform (cFLIPL)-IKKα interactions inhibit IRF7 activation, representing a new cellular strategy to inhibit IFNα expression. PMID:29222334
Exploring digenic inheritance in arrhythmogenic cardiomyopathy. PMID:29221435
Immunohistochemical Localization of Fibrinogen C Domain Containing 1 on Epithelial and Mucosal Surfaces in Human Tissues. PMID:29220632
Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling. PMID:29212039
Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer. PMID:29210986
Co-expression network analysis identified FCER1G in association with progression and prognosis in human clear cell renal cell carcinoma. PMID:29209141
A novel correlation between ATP5A1 gene expression and progression of human clear cell renal cell carcinoma identified by co‑expression analysis. PMID:29207195
P4HB and PDIA3 are associated with tumor progression and therapeutic outcome of diffuse gliomas. PMID:29207176
The Human Cell Atlas. PMID:29206104
ATP2C2 and DYX1C1 are putative modulators of dyslexia-related MMR. PMID:29201552
New Strategies and Challenges in Lung Proteomics and Metabolomics. An Official American Thoracic Society Workshop Report. PMID:29192815
Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis. PMID:29190970
The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model. PMID:29190822
Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling. PMID:29187877
FAM13A as a Novel Hypoxia-Induced Gene in Non-Small Cell Lung Cancer. PMID:29187867
Associations between imprinted gene expression in the placenta, human fetal growth and preeclampsia. PMID:29187609
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control. PMID:29186125
A hypermorphic antioxidant response element is associated with increased MS4A6A expression and Alzheimer's disease. PMID:29179108
MitoCore: a curated constraint-based model for simulating human central metabolism. PMID:29178872
ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis. PMID:29178829
Spatiotemporal Proteomic Profiling of Huntington's Disease Inclusions Reveals Widespread Loss of Protein Function. PMID:29166617
FunCoup 4: new species, data, and visualization. PMID:29165593
An expression screen for aged-dependent microRNAs identifies miR-30a as a key regulator of aging features in human epidermis. PMID:29165315
IGFBP-4 expression is adversely associated with lung cancer prognosis. PMID:29163706
3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry. PMID:29162797
De novo variants in EBF3 are associated with hypotonia, developmental delay, intellectual disability, and autism. PMID:29162653
Interest of integrins targeting in glioblastoma according to tumor heterogeneity and cancer stem cell paradigm: an update. PMID:29156849
Zinc-finger proteins in health and disease. PMID:29152378
CD163 as a novel target gene of STAT3 is a potential therapeutic target for gastric cancer. PMID:29152078
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY. PMID:29149325
Immune signature profiling identified predictive and prognostic factors for esophageal squamous cell carcinoma. PMID:29147607
Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. PMID:29145845
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family. PMID:29142246
LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness. PMID:29137369
A Role of Sp1 Binding Motifs in Basal and Large T-Antigen-Induced Promoter Activities of Human Polyomavirus HPyV9 and Its Variant UF-1. PMID:29135936
Pathways of cellular proteostasis in aging and disease. PMID:29127110
Human Organ Tissue Identification by Targeted RNA Deep Sequencing to Aid the Investigation of Traumatic Injury. PMID:29125589
Integrative analysis of BSG expression in NPC through immunohistochemistry and public high-throughput gene expression data. PMID:29118919
EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis. PMID:29118343
ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance. PMID:29117122
Prognostic microRNAs and their potential molecular mechanism in pancreatic cancer: A study based on The Cancer Genome Atlas and bioinformatics investigation. PMID:29115476
Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View. PMID:29114206
Bioinformatics analysis of SRSF1-controlled gene networks in colorectal cancer. PMID:29113173
VarCards: an integrated genetic and clinical database for coding variants in the human genome. PMID:29112736
APOL1 Nephrotoxicity: What Does Ion Transport Have to Do With It? PMID:29110762
Comprehensive bioinformatics analysis of the characterization and determination underlying mechanisms of over-expression and co-expression of genes residing on 20q in colorectal cancer. PMID:29108255
Location matters: distinct DNA methylation patterns in GABAergic interneuronal populations from separate microcircuits within the human hippocampus. PMID:29106556
Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma. PMID:29103912
Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy. PMID:29100430
The RNA exosome and RNA exosome-linked disease. PMID:29093021
GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. PMID:29092903
An Investigation of the Single and Combined Phthalate Metabolite Effects on Human Chorionic Gonadotropin Expression in Placental Cells. PMID:29089286
Non-small cell lung cancer (NSCLC), EGFR downstream pathway activation and TKI targeted therapies sensitivity: Effect of the plasma membrane-associated NEU3. PMID:29088281
Commentary: HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing of CD44 during epithelial-mesenchymal transition. PMID:29085822
Helicobacter pylori Affects the Antigen Presentation Activity of Macrophages Modulating the Expression of the Immune Receptor CD300E through miR-4270. PMID:29085364
COMICS: Cartoon Visualization of Omics Data in Spatial Context Using Anatomical Ontologies. PMID:29083911
Ca2+ protein alpha 1D of CaV1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity. PMID:29079724
Framework and resource for more than 11,000 gene-transcript-protein-reaction associations in human metabolism. PMID:29078384
Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins. PMID:29075625
Trends in GPCR drug discovery: new agents, targets and indications. PMID:29075003
Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression. PMID:29069604
Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism. PMID:29069457
The DifferentialNet database of differential protein-protein interactions in human tissues. PMID:29069447
TCSBN: a database of tissue and cancer specific biological networks. PMID:29069445
Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor. PMID:29066620
The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance. PMID:29064388
The Challenge of Human Spermatozoa Proteome: A Systematic Review. PMID:29062791
A rapid and accurate approach for prediction of interactomes from co-elution data (PrInCE). PMID:29061110
Molecular-based diagnosis of multiple sclerosis and its progressive stage. PMID:29059494
Xenbase: a genomic, epigenomic and transcriptomic model organism database. PMID:29059324
Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease. PMID:29059182
miR-708-5p: a microRNA with emerging roles in cancer. PMID:29050362
CNS cell-type localization and LPS response of TLR signaling pathways. PMID:29043065
Ancestors' dietary patterns and environments could drive positive selection in genes involved in micronutrient metabolism-the case of cofactor transporters. PMID:29043008
The serum protein renalase reduces injury in experimental pancreatitis. PMID:29042438
The online Tabloid Proteome: an annotated database of protein associations. PMID:29040688
Advances in the Chromosome-Centric Human Proteome Project: looking to the future. PMID:29039980
Hepatic differentiation of human iPSCs in different 3D models: A comparative study. PMID:29039463
Cell-surface major vault protein promotes cancer progression through harboring mesenchymal and intermediate circulating tumor cells in hepatocellular carcinomas. PMID:29038587
TissGDB: tissue-specific gene database in cancer. PMID:29036590
Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β. PMID:29030430
CAR T Therapy Targeting ICAM-1 Eliminates Advanced Human Thyroid Tumors. PMID:29025766
In-depth proteomic analysis of tissue interstitial fluid for hepatocellular carcinoma serum biomarker discovery. PMID:29024941
ANO9/TMEM16J promotes tumourigenesis via EGFR and is a novel therapeutic target for pancreatic cancer. PMID:29024940
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data. PMID:29021715
Identification of Serological Biomarkers for Early Diagnosis of Lung Cancer Using a Protein Array-Based Approach. PMID:29021294
Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML. PMID:29017060
Temporal expression profiling of plasma proteins reveals oxidative stress in early stages of Type 1 Diabetes progression. PMID:28993202
Data Resources for Human Functional Genomics. PMID:28989986
Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development. PMID:28985528
Few Nuclear-Encoded Mitochondrial Gene Duplicates Contribute to Male Germline-Specific Functions in Humans. PMID:28985295
Chronic β2 -adrenoceptor agonist treatment alters muscle proteome and functional adaptations induced by high intensity training in young men. PMID:28983994
Role of adaptor protein p66Shc in renal pathologies. PMID:28978535
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. PMID:28977666
IMOTA: an interactive multi-omics tissue atlas for the analysis of human miRNA-target interactions. PMID:28977416
Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond-like features. PMID:28972538
The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. PMID:28965825
Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice. PMID:28961327
Folding Membrane Proteins by Deep Transfer Learning. PMID:28957654
Human hepatic gene expression signature of non-alcoholic fatty liver disease progression, a meta-analysis. PMID:28955037
Alterations in mRNA 3' UTR Isoform Abundance Accompany Gene Expression Changes in Human Huntington's Disease Brains. PMID:28954224
Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers. PMID:28953906
Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma. PMID:28945795
Protein structure and phenotypic analysis of pathogenic and population missense variants in STXBP1. PMID:28944233
The human protein atlas: A spatial map of the human proteome. PMID:28940711
The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays. PMID:28938075
In situ protein detection with enhanced specificity using DNA-conjugated antibodies and proximity ligation. PMID:28937142
hnRNP L controls HPV16 RNA polyadenylation and splicing in an Akt kinase-dependent manner. PMID:28934469
NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease. PMID:28934392
Involvement of the Integrin α1β1 in the Progression of Colorectal Cancer. PMID:28933766
Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling. PMID:28925397
Inflammatory cytokine production in tumor cells upon chemotherapy drug exposure or upon selection for drug resistance. PMID:28915246
A high resolution atlas of gene expression in the domestic sheep (Ovis aries). PMID:28915238
Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis. PMID:28912276
miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells. PMID:28905214
Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases. PMID:28902166
Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye. PMID:28901286
Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. PMID:28898695
RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. PMID:28894007
Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in Trypanosoma brucei. PMID:28887303
Analysis of the whole transcriptome from gingivo-buccal squamous cell carcinoma reveals deregulated immune landscape and suggests targets for immunotherapy. PMID:28886030
Slow fusion pore expansion creates a unique reaction chamber for co-packaged cargo. PMID:28882880
IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer. PMID:28882129
Identification of KANSARL as the first cancer predisposition fusion gene specific to the population of European ancestry origin. PMID:28881586
Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation. PMID:28878392
Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. PMID:28878041
IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury. PMID:28877988
Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers. PMID:28874546
Radiogenomics: Identification of Genomic Predictors for Radiation Toxicity. PMID:28865512
Krüppel-like factor 5 is essential for maintenance of barrier function in mouse colon. PMID:28864500
The Scaffolding Protein IQGAP1 Interacts with NLRC3 and Inhibits Type I IFN Production. PMID:28864474
The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma. PMID:28862757
Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. PMID:28861084
The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene. PMID:28859078
CTLA-4/CD80 pathway regulates T cell infiltration into pancreatic cancer. PMID:28856392
Inflammatory infiltrates in parathyroid tumors. PMID:28855268
Position Matters: Network Centrality Considerably Impacts Rates of Protein Evolution in the Human Protein-Protein Interaction Network. PMID:28854629
Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project. PMID:28853897
Extracellular Cytosolic Aspartate Aminotransferase Promotes Axonal Growth and Object Recognition Memory. PMID:28852933
Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome. PMID:28845240
ImmunoPET imaging of tissue factor expression in pancreatic cancer with 89Zr-Df-ALT-836. PMID:28843831
Sequence-structure relationships, expression profiles, and disease-associated mutations in the paralogs of phosphoglucomutase 1. PMID:28837627
Pervasive coexpression of spatially proximal genes is buffered at the protein level. PMID:28835372
Embryonic Stem Cell-Like Population in Dupuytren's Disease Expresses Components of the Renin-Angiotensin System. PMID:28831359
Nfib hemizygous mice are protected from hyperoxic lung injury and death. PMID:28830981
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations. PMID:28828399
MicroRNAs tend to synergistically control expression of genes encoding extensively-expressed proteins in humans. PMID:28828274
The role of the C-terminal D0 domain of flagellin in activation of Toll like receptor 5. PMID:28827825
Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis. PMID:28827734
Facile single-stranded DNA sequencing of human plasma DNA via thermostable group II intron reverse transcriptase template switching. PMID:28827600
Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision. PMID:28827588
Network analyses identify liver-specific targets for treating liver diseases. PMID:28827398
Systematic and Quantitative Assessment of Hydrogen Peroxide Reactivity With Cysteines Across Human Proteomes. PMID:28827280
Superoxide Dismutases in Pancreatic Cancer. PMID:28825637
Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma. PMID:28819306
Overexpression of Topoisomerase 2-Alpha Confers a Poor Prognosis in Pancreatic Adenocarcinoma Identified by Co-Expression Analysis. PMID:28815403
ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism. PMID:28811980
The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. PMID:28808947
High RBM3 expression is associated with an improved survival and oxaliplatin response in patients with metastatic colorectal cancer. PMID:28800641
Lumican delays melanoma growth in mice and drives tumor molecular assembly as well as response to matrix-targeted TAX2 therapeutic peptide. PMID:28794454
Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth. PMID:28794006
Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins. PMID:28793925
CODA: Integrating multi-level context-oriented directed associations for analysis of drug effects. PMID:28790372
Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity. PMID:28790177
Current State and Future Trends to Optimize the Care of African Americans with End-Stage Renal Disease. PMID:28787724
The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription. PMID:28787591
Uromodulin: from physiology to rare and complex kidney disorders. PMID:28781372
The Image Data Resource: A Bioimage Data Integration and Publication Platform. PMID:28775673
MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension. PMID:28771472
Kinase Activity of Fibroblast Growth Factor Receptor 3 Regulates Activity of the Papillomavirus E2 Protein. PMID:28768864
Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE. PMID:28768697
The Bos taurus-Bos indicus balance in fertility and milk related genes. PMID:28763475
Genome-Scale Modeling of NADPH-Driven β-Lapachone Sensitization in Head and Neck Squamous Cell Carcinoma. PMID:28762750
PLA2R binds to the annexin A2-S100A10 complex in human podocytes. PMID:28761153
SLC39A8 deficiency: biochemical correction and major clinical improvement by manganese therapy. PMID:28749473
Wilhelm et al. reply. PMID:28748931
Increased ERCC1 expression is linked to chromosomal aberrations and adverse tumor biology in prostate cancer. PMID:28747165
New Challenges to Study Heterogeneity in Cancer Redox Metabolism. PMID:28744456
The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation. PMID:28744217
Lactate oxidation facilitates growth of Mycobacterium tuberculosis in human macrophages. PMID:28744015
Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis. PMID:28742074
Erratum to: Treadmill Exercise Attenuates α-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson's Disease. PMID:28741160
HEMO, an ancestral endogenous retroviral envelope protein shed in the blood of pregnant women and expressed in pluripotent stem cells and tumors. PMID:28739914
Neisseria cinerea Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines. PMID:28739825
Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes. PMID:28736931
Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model. PMID:28736522
Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. PMID:28733458
Expression of the scaffold connector enhancer of kinase suppressor of Ras 1 (CNKSR1) is correlated with clinical outcome in pancreatic cancer. PMID:28732488
UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses. PMID:28732212
Gene expression signatures of human cell and tissue longevity. PMID:28721269
Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes. PMID:28717874
Bacterial infection imaging with [18F]fluoropropyl-trimethoprim. PMID:28716936
Differentiating mouse embryonic stem cells express markers of human endometrium. PMID:28716123
Predictive model of thrombospondin-1 and vascular endothelial growth factor in breast tumor tissue. PMID:28713587
A community proposal to integrate proteomics activities in ELIXIR. PMID:28713550
Arterial immune protein expression demonstrates the complexity of immune responses in Kawasaki disease arteritis. PMID:28707750
Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol. PMID:28701464
Genes Involved in Long-Term Memory Are Expressed in Testis of Cryptorchid Boys and Respond to GnRHa Treatment. PMID:28700985
Compound heterozygous SLC19A3 mutations further refine the critical promoter region for biotin-thiamine-responsive basal ganglia disease. PMID:28696212
Arete - candidate gene prioritization using biological network topology with additional evidence types. PMID:28694847
Putative role of an SLC45 H+/sugar cotransporter in mammalian spermatozoa. PMID:28689241
Spatiotemporal Proteomic Profiling of Human Cerebral Development. PMID:28687556
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies. PMID:28683746
Proteomic profiling of archaeological human bone. PMID:28680659
The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases. PMID:28680390
A Cell Fusion-Based Screening Method Identifies Glycosylphosphatidylinositol-Anchored Protein Ly6e as the Receptor for Mouse Endogenous Retroviral Envelope Syncytin-A. PMID:28679758
The Enterococcus faecalis virulence factor ElrA interacts with the human Four-and-a-Half LIM Domains Protein 2. PMID:28676674
Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide. PMID:28675388
Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells. PMID:28674184
Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway. PMID:28674149
PLA2R and THSD7A: Disparate Paths to the Same Disease? PMID:28674044
Institutional profile: the national Swedish academic drug discovery & development platform at SciLifeLab. PMID:28670468
Cervical Cancer Neoantigen Landscape and Immune Activity is Associated with Human Papillomavirus Master Regulators. PMID:28670312
Gene Expression Profiles for the Identification of Prevalent Atrial Fibrillation. PMID:28666990
KIBRA attains oncogenic activity by repressing RASSF1A. PMID:28664913
An atlas of bloodstream-accessible bone marrow proteins for site-directed therapy of acute myeloid leukemia. PMID:28663580
CARMIL family proteins as multidomain regulators of actin-based motility. PMID:28663287
METTL21B Is a Novel Human Lysine Methyltransferase of Translation Elongation Factor 1A: Discovery by CRISPR/Cas9 Knockout. PMID:28663172
The atopic march: current insights into skin barrier dysfunction and epithelial cell-derived cytokines. PMID:28658558
Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine. PMID:28655899
Affimer proteins are versatile and renewable affinity reagents. PMID:28654419
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway. PMID:28644436
Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice. PMID:28644012
Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology. PMID:28642799
A liver-specific gene expression panel predicts the differentiation status of in vitro hepatocyte models. PMID:28640507
The role of cullin4B in human cancers. PMID:28630798
Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities. PMID:28630053
Alternative Polyadenylation Patterns for Novel Gene Discovery and Classification in Cancer. PMID:28624626
Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells. PMID:28623304
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. PMID:28622513
Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines. PMID:28621943
The Therapeutic Potential of Anti-Inflammatory Exerkines in the Treatment of Atherosclerosis. PMID:28608819
Remodeling adipose tissue through in silico modulation of fat storage for the prevention of type 2 diabetes. PMID:28606124
Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS. PMID:28604659
The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development. PMID:28603670
Seasonal and flight-related variation of galectin expression in heart, liver and flight muscles of yellow-rumped warblers (Setophaga coronata). PMID:28597244
A comprehensive analysis and annotation of human normal urinary proteome. PMID:28596590
Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes. PMID:28596423
Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer. PMID:28596133
Computational prediction of lncRNA-mRNA interactionsby integrating tissue specificity in human transcriptome. PMID:28595592
Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism. PMID:28588231
NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes. PMID:28585553
Development of Novel Monoclonal Antibodies for Evaluation of Transmembrane Prostate Androgen-Induced Protein 1 (TMEPAI) Expression Patterns in Gastric Cancer. PMID:28584893
Alternative splicing shapes transcriptome but not proteome diversity in Physcomitrella patens. PMID:28578384
βIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons. PMID:28576936
Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease. PMID:28575649
Mutations in SULT2B1 Cause Autosomal-Recessive Congenital Ichthyosis in Humans. PMID:28575648
Genome-wide profiling of Sus scrofa circular RNAs across nine organs and three developmental stages. PMID:28575165
Biodistribution and Radiation Dosimetry of 18F-FTC-146 in Humans. PMID:28572487
Network analysis of the genomic basis of the placebo effect. PMID:28570268
Urinary exosomes reveal protein signatures in hypertensive patients with albuminuria. PMID:28562335
The Transcriptional Landscape of p53 Signalling Pathway. PMID:28558959
Canine Brachycephaly Is Associated with a Retrotransposon-Mediated Missplicing of SMOC2. PMID:28552356
A novel PRKAG2 mutation in a Chinese family with cardiac hypertrophy and ventricular pre-excitation. PMID:28546535
A random effects model for the identification of differential splicing (REIDS) using exon and HTA arrays. PMID:28545391
A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PMID:28542535
Analysis of primary-miRNA-3662 and its mature form may improve detection of the lung adenocarcinoma. PMID:28540403
Role of Intestinal LXRα in Regulating Post-prandial Lipid Excursion and Diet-Induced Hypercholesterolemia and Hepatic Lipid Accumulation. PMID:28536535
HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses. PMID:28533942
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. PMID:28530674
pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase. PMID:28530236
Role of carbonic anhydrases in skin wound healing. PMID:28524177
Architecture of the human interactome defines protein communities and disease networks. PMID:28514442
Pro-necrotic molecules impact local immunosurveillance in human breast cancer. PMID:28507808
Protein Markers Associated with an ALDH Sub-Population in Colorectal Cancer. PMID:28503055
MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome. PMID:28502612
Homogeneous pancreatic cancer spheroids mimic growth pattern of circulating tumor cell clusters and macrometastases: displaying heterogeneity and crater-like structure on inner layer. PMID:28497169
Revisiting olfactory receptors as putative drivers of cancer. PMID:28492065
Transcriptomics and the Mediterranean Diet: A Systematic Review. PMID:28486416
TSNAD: an integrated software for cancer somatic mutation and tumour-specific neoantigen detection. PMID:28484631
Claudin-4 Expression is Associated With Survival in Ovarian Cancer But Not With Chemotherapy Response. PMID:28481779
Expression and targeting of transcription factor ATF5 in dog gliomas. PMID:28480569
Multi-omics approaches to disease. PMID:28476144
Pancreatic Islet Protein Complexes and Their Dysregulation in Type 2 Diabetes. PMID:28473845
Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer. PMID:28469007
Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes. PMID:28465537
Immunohistochemical evaluation of epithelial ovarian carcinomas identifies three different expression patterns of the MX35 antigen, NaPi2b. PMID:28464843
The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF. PMID:28455445
PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer. PMID:28454353
Tissue Distribution of the MERS-Coronavirus Receptor in Bats. PMID:28446791
Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression. PMID:28445977
Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma. PMID:28445125
Factors influencing biased agonism in recombinant cells expressing the human α1A -adrenoceptor. PMID:28444738
A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. PMID:28444561
Social Behavior of Pet Dogs Is Associated with Peripheral OXTR Methylation. PMID:28443051
Elevated glypican-1 expression is associated with an unfavorable prognosis in pancreatic ductal adenocarcinoma. PMID:28440066
Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease. PMID:28438806
Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence. PMID:28433799
Angiotensin-converting enzyme 2 is a potential therapeutic target for EGFR-mutant lung adenocarcinoma. PMID:28433633
Gastric Proteins MUC5AC and TFF1 as Potential Diagnostic Markers of Colonic Sessile Serrated Adenomas/Polyps. PMID:28430953
Intrinsic protein disorder reduces small-scale gene duplicability. PMID:28430886
Evolutionary changes in lamin expression in the vertebrate lineage. PMID:28430006
Vaccination with inhibin-α provides effective immunotherapy against testicular stromal cell tumors. PMID:28428886
Expression of D-Amino Acid Oxidase (DAO/DAAO) and D-Amino Acid Oxidase Activator (DAOA/G72) during Development and Aging in the Human Post-mortem Brain. PMID:28428746
Precision physiology and rescue of brain ion channel disorders. PMID:28428202
MNS16A tandem repeat minisatellite of human telomerase gene: functional studies in colorectal, lung and prostate cancer. PMID:28427205
The effects of DLEU1 gene expression in Burkitt lymphoma (BL): potential mechanism of chemoimmunotherapy resistance in BL. PMID:28427156
When cancer needs what's non-essential. PMID:28422952
The clinical value, regulatory mechanisms, and gene network of the cancer-testis gene STK31 in pancreatic cancer. PMID:28422722
Global gene expression profiling of healthy human brain and its application in studying neurological disorders. PMID:28420888
Family with sequence similarity 13C (FAM13C) overexpression is an independent prognostic marker in prostate cancer. PMID:28415558
Comparative expression profiling of testis-enriched genes regulated during the development of spermatogonial cells. PMID:28414809
Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques. PMID:28414332
The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease. PMID:28410559
Tspan2: a tetraspanin protein involved in oligodendrogenesis and cancer metastasis. PMID:28408487
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. PMID:28407145
The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis. PMID:28405519
NUSAP1 promotes invasion and metastasis of prostate cancer. PMID:28404898
Shaping proteostasis at the cellular, tissue, and organismal level. PMID:28400444
Machine learning in computational biology to accelerate high-throughput protein expression. PMID:28398465
Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine. PMID:28396636
High-confidence coding and noncoding transcriptome maps. PMID:28396519
Proof-of-Concept Workflow for Establishing Reference Intervals of Human Urine Proteome for Monitoring Physiological and Pathological Changes. PMID:28396014
Emerging proteomics biomarkers and prostate cancer burden in Africa. PMID:28388542
Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility. PMID:28386063
The Proteins API: accessing key integrated protein and genome information. PMID:28383659
Novel RNA biomarkers of prostate cancer revealed by RNA-seq analysis of formalin-fixed samples obtained from Russian patients. PMID:28380430
Detect tissue heterogeneity in gene expression data with BioQC. PMID:28376718
Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci. PMID:28374850
VerSeDa: vertebrate secretome database. PMID:28365718
A Cell-Surface Membrane Protein Signature for Glioblastoma. PMID:28365151
The challenges with the validation of research antibodies. PMID:28357047
BCL6 promotes glioma and serves as a therapeutic target. PMID:28356518
ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. PMID:28351972
Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans. PMID:28346228
PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription. PMID:28345603
A quantitative method for screening and identifying molecular targets for nanomedicine. PMID:28341549
DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation. PMID:28340599
Genotype-based gene signature of glioma risk. PMID:28339748
Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice. PMID:28330952
MCPIP1, alias Regnase-1 binds and cleaves mRNA of C/EBPβ. PMID:28328949
Elevated fecal peptidase D at onset of colitis in Galphai2-/- mice, a mouse model of IBD. PMID:28323866
Visualization of tumor heterogeneity by in situ padlock probe technology in colorectal cancer. PMID:28321501
Inhibitors of GLUT/SLC2A Enhance the Action of BCNU and Temozolomide against High-Grade Gliomas. PMID:28319810
ExCAPE-DB: an integrated large scale dataset facilitating Big Data analysis in chemogenomics. PMID:28316655
The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals. PMID:28300784
Identification of a novel locus associated with skin colour in African-admixed populations. PMID:28300201
IRFinder: assessing the impact of intron retention on mammalian gene expression. PMID:28298237
Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer. PMID:28290516
Proteome-wide Mapping of Endogenous SUMOylation Sites in Mouse Testis. PMID:28289178
Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance. PMID:28287408
Ornithine Aminotransferase, an Important Glutamate-Metabolizing Enzyme at the Crossroads of Multiple Metabolic Pathways. PMID:28272331
Modulation of the Proteostasis Machinery to Overcome Stress Caused by Diminished Levels of t6A-Modified tRNAs in Drosophila. PMID:28272317
Social network architecture of human immune cells unveiled by quantitative proteomics. PMID:28263321
Integrating genomic data from high-throughput studies with computational modeling reveals differences in the molecular basis of hyposalivation between type 1 and type 2 diabetes. PMID:28255753
Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD. PMID:28254760
Let There Be Light! PMID:28248246
Genome-Scale Reconstruction of the Human Astrocyte Metabolic Network. PMID:28243200
DNA breaks and chromatin structural changes enhance the transcription of autoimmune regulator target genes. PMID:28242760
Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells. PMID:28241063
The Heterocellular Emergence of Colorectal Cancer. PMID:28239669
Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer. PMID:28235401
Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid. PMID:28223357
The versatility and paradox of GDF 11. PMID:28223232
Human Nup98 regulates the localization and activity of DExH/D-box helicase DHX9. PMID:28221134
Mutations in KIAA0753 cause Joubert syndrome associated with growth hormone deficiency. PMID:28220259
ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms? PMID:28220105
A Systematic Evaluation of Methods for Tailoring Genome-Scale Metabolic Models. PMID:28215528
Transcriptomic dynamics of breast cancer progression in the MMTV-PyMT mouse model. PMID:28212608
Identification of Extracellular Segments by Mass Spectrometry Improves Topology Prediction of Transmembrane Proteins. PMID:28211907
In situ generated D-peptidic nanofibrils as multifaceted apoptotic inducers to target cancer cells. PMID:28206986
A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFβ signaling and cause autosomal dominant spondylocarpotarsal synostosis. PMID:28205584
Paraneoplastic cerebellar degeneration associated with anti-ITPR1 antibodies. PMID:28203616
Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome. PMID:28196901
Untargeted metabolomics of colonic digests reveals kynurenine pathway metabolites, dityrosine and 3-dehydroxycarnitine as red versus white meat discriminating metabolites. PMID:28195169
Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells. PMID:28194645
Gene-based segregation method for identifying rare variants in family-based sequencing studies. PMID:28191685
The Drosophila Gene Expression Tool (DGET) for expression analyses. PMID:28187709
Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. PMID:28183841
Cloning, expression and molecular characterization of a Cystoisospora suis specific uncharacterized merozoite protein. PMID:28173829
The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients. PMID:28173181
The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men. PMID:28171660
Characterization of H type 1 and type 1 N-acetyllactosamine glycan epitopes on ovarian cancer specifically recognized by the anti-glycan monoclonal antibody mAb-A4. PMID:28167527
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. PMID:28166215
Insights into Diabetic Kidney Disease Using Urinary Proteomics and Bioinformatics. PMID:28159781
Evaluation of [18F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer. PMID:28157626
MISTIC-fusion proteins as antigens for high quality membrane protein antibodies. PMID:28148968
TBK1: a new player in ALS linking autophagy and neuroinflammation. PMID:28148298
Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast. PMID:28122942
GAD1 Gene Expression in Blood of Patients with First-Episode Psychosis. PMID:28122016
Accelerating the search for the missing proteins in the human proteome. PMID:28117396
Bicarbonate-sensing soluble adenylyl cyclase is present in the cell cytoplasm and nucleus of multiple shark tissues. PMID:28108644
Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress. PMID:28107650
A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network. PMID:28105929
Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention? PMID:28105425
Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis. PMID:28104354
GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord. PMID:28103900
Three-Dimensional Bioprinting Nanotechnologies towards Clinical Application of Stem Cells and Their Secretome in Salivary Gland Regeneration. PMID:28090208
FAM83 family oncogenes are broadly involved in human cancers: an integrative multi-omics approach. PMID:28078827
A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis. PMID:28069747
Analysis of Whole Exome Sequencing with Cardiometabolic Traits Using Family-Based Linkage and Association in the IRAS Family Study. PMID:28067407
Differential proteomic and oxidative profiles unveil dysfunctional protein import to adipocyte mitochondria in obesity-associated aging and diabetes. PMID:28064117
Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate. PMID:28059163
Network-Based Approach to Identify Potential Targets and Drugs that Promote Neuroprotection and Neurorepair in Acute Ischemic Stroke. PMID:28054643
A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma. PMID:28052770
PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion. PMID:28051998
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. PMID:28049840
Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View. PMID:28036022
A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival. PMID:28030848
Redox Control of Skeletal Muscle Regeneration. PMID:28027662
On-the-fly selection of cell-specific enhancers, genes, miRNAs and proteins across the human body using SlideBase. PMID:28025337
PD-L1 Is Not Constitutively Expressed on Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-γ and Can Be Expressed in the Tumor Microenvironment. PMID:28018348
Zebrafish Models for Dyslipidemia and Atherosclerosis Research. PMID:28018294
Secreted Proteins Defy the Expression Level-Evolutionary Rate Anticorrelation. PMID:28007979
Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection. PMID:28002492
The pan-cancer pathological regulatory landscape. PMID:28000771
Liver Enzymes and Risk of Ischemic Heart Disease and Type 2 Diabetes Mellitus: A Mendelian Randomization Study. PMID:27996050
Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility. PMID:27996046
Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma. PMID:27993630
Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer. PMID:27980417
Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model. PMID:27980102
Classical complement pathway activation in the nasal tissue of patients with chronic rhinosinusitis. PMID:27979430
Salivary and pellicle proteome: A datamining analysis. PMID:27966577
Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases. PMID:27965669
Gene-specific correlation of RNA and protein levels in human cells and tissues. PMID:27951527
Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer. PMID:27935821
Advances of the HUPO Human Proteome Project with broad applications for life sciences research. PMID:27935328
Expression of Cav1.3 calcium channel in the human and mouse colon: posttranscriptional inhibition by IFNγ. PMID:27932504
RNA sequencing of chorionic villi from recurrent pregnancy loss patients reveals impaired function of basic nuclear and cellular machinery. PMID:27929073
Tollip, an early regulator of the acute inflammatory response in the substantia nigra. PMID:27927222
Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome. PMID:27923875
A highly specific ratiometric two-photon fluorescent probe to detect dipeptidyl peptidase IV in plasma and living systems. PMID:27923191
Control of Gene Expression by RNA Binding Protein Action on Alternative Translation Initiation Sites. PMID:27923063
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. PMID:27920155
Maximising the potential of AKT inhibitors as anti-cancer treatments. PMID:27919797
Hepatocarcinogenesis in transgenic mice carrying hepatitis B virus pre-S/S gene with the sW172* mutation. PMID:27918551
Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation. PMID:27911818
Brain transcriptome atlases: a computational perspective. PMID:27909802
Quantitative and Selective Analysis of Feline Growth Related Proteins Using Parallel Reaction Monitoring High Resolution Mass Spectrometry. PMID:27907059
Sensitivity of GBM cells to cAMP agonist-mediated apoptosis correlates with CD44 expression and agonist resistance with MAPK signaling. PMID:27906173
The TissueNet v.2 database: A quantitative view of protein-protein interactions across human tissues. PMID:27899616
Receptor-Type Protein-Tyrosine Phosphatase ζ and Colony Stimulating Factor-1 Receptor in the Intestine: Cellular Expression and Cytokine- and Chemokine Responses by Interleukin-34 and Colony Stimulating Factor-1. PMID:27898738
The Human Skeletal Muscle Proteome Project: a reappraisal of the current literature. PMID:27897395
IDENTIFYING CANCER SPECIFIC METABOLIC SIGNATURES USING CONSTRAINT-BASED MODELS. PMID:27897000
A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction. PMID:27896283
UGT1A1*6, UGT1A7*3 and UGT1A9*1b polymorphisms are predictive markers for severe toxicity in patients with metastatic gastrointestinal cancer treated with irinotecan-based regimens. PMID:27895797
Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. PMID:27894104
Physiologically-based modeling to predict the clinical behavior of monoclonal antibodies directed against lymphocyte antigens. PMID:27892793
The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4. PMID:27888281
Patterns of ribosomal protein expression specify normal and malignant human cells. PMID:27884178
Personalized Proteomics: The Future of Precision Medicine. PMID:27882306
Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL. PMID:27875259
Quantitative secretomic analysis of pancreatic cancer cells in serum-containing conditioned medium. PMID:27869176
Evaluation of the genetic basis of primary hypoadrenocorticism in Standard Poodles using SNP array genotyping and whole-genome sequencing. PMID:27864587
ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer. PMID:27863473
Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation. PMID:27861515
SNAP23 promotes the malignant process of ovarian cancer. PMID:27855700
Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. PMID:27854507
RNA-seq based transcriptomic map reveals new insights into mouse salivary gland development and maturation. PMID:27852218
[Autoantibody-associated autoimmune encephalitis and cerebellitis : Clinical presentation, diagnostic work-up and treatment]. PMID:27847964
Haploinsufficiency of KMT2B, Encoding the Lysine-Specific Histone Methyltransferase 2B, Results in Early-Onset Generalized Dystonia. PMID:27839873
Adhesion GPCRs in Tumorigenesis. PMID:27832497
Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues. PMID:27824084
Microarray expression profiling identifies genes, including cytokines, and biofunctions, as diapedesis, associated with a brain metastasis from a papillary thyroid carcinoma. PMID:27822408
Illuminating a plant's tissue-specific metabolic diversity using computational metabolomics and information theory. PMID:27821729
Modeling Gene Regulation in Liver Hepatocellular Carcinoma with Random Forests. PMID:27818995
From Proteomic Analysis to Potential Therapeutic Targets: Functional Profile of Two Lung Cancer Cell Lines, A549 and SW900, Widely Studied in Pre-Clinical Research. PMID:27814385
Characterization of a male reproductive transcriptome for Peromyscus eremicus (Cactus mouse). PMID:27812417
Progress in the Chromosome-Centric Human Proteome Project as Highlighted in the Annual Special Issue IV. PMID:27809547
Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx. PMID:27805811
Downregulation of EGFR in hypoxic, diffusion-limited areas of squamous cell carcinomas of the head and neck. PMID:27802455
Path2enet: generation of human pathway-derived networks in an expression specific context. PMID:27801297
Evolutionary hallmarks of the human proteome: chasing the age and coregulation of protein-coding genes. PMID:27801289
RNA-Seq Transcriptomic Responses of Full-Thickness Dermal Excision Wounds to Pseudomonas aeruginosa Acute and Biofilm Infection. PMID:27792773
Upstream Open Reading Frames Located in the Leader of Protein Kinase Mζ mRNA Regulate Its Translation. PMID:27790092
Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy. PMID:27788492
Infantile Hemangioma Originates From A Dysregulated But Not Fully Transformed Multipotent Stem Cell. PMID:27786256
Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy. PMID:27776522
The state of play in higher eukaryote gene annotation. PMID:27773922
Inducible expression of cancer-testis antigens in human prostate cancer. PMID:27769045
Identification of internalin-A-like virulent proteins in Leishmania donovani. PMID:27765050
Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma. PMID:27764136
Equilibrative nucleoside transporters-A review. PMID:27759477
N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models. PMID:27757071
An Ancient Fecundability-Associated Polymorphism Switches a Repressor into an Enhancer of Endometrial TAP2 Expression. PMID:27745831
Molecular classification of Crohn's disease reveals two clinically relevant subtypes. PMID:27742763
The circadian coordination of cell biology. PMID:27738003
Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research. PMID:27713570
Alternative Splicing May Not Be the Key to Proteome Complexity. PMID:27712956
Network analysis of mitonuclear GWAS reveals functional networks and tissue expression profiles of disease-associated genes. PMID:27704213
Profiling cancer testis antigens in non-small-cell lung cancer. PMID:27699219
Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling. PMID:27697518
Targeted next-generation sequencing for TP53, RAS, BRAF, ALK and NF1 mutations in anaplastic thyroid cancer. PMID:27696251
Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions. PMID:27694853
Decreased Expression of SRSF2 Splicing Factor Inhibits Apoptotic Pathways in Renal Cancer. PMID:27690003
Integration of zebrafish fin regeneration genes with expression data of human tumors in silico uncovers potential novel melanoma markers. PMID:27689402
Detection of candidate biomarkers of prostate cancer progression in serum: a depletion-free 3D LC/MS quantitative proteomics pilot study. PMID:27685442
The NIH Protein Capture Reagents Program (PCRP): a standardized protein affinity reagent toolbox. PMID:27684578
Deconvolution of the Human Endothelial Transcriptome. PMID:27684186
Proteomic Analysis of Non-depleted Serum Proteins from Bottlenose Dolphins Uncovers a High Vanin-1 Phenotype. PMID:27667588
Multi-omics Quantification of Species Variation of Escherichia coli Links Molecular Features with Strain Phenotypes. PMID:27667363
A bead-based western for high-throughput cellular signal transduction analyses. PMID:27659302
Isolation and expression of the human gametocyte-specific factor 1 gene (GTSF1) in fetal ovary, oocytes, and preimplantation embryos. PMID:27646122
A novel mouse model for the identification of thioredoxin-1 protein interactions. PMID:27639450
Fluid biomarkers for mild traumatic brain injury and related conditions. PMID:27632903
Validation of specificity of antibodies for immunohistochemistry: the case of ROR2. PMID:27631337
Constructing Bayesian networks by integrating gene expression and copy number data identifies NLGN4Y as a novel regulator of prostate cancer progression. PMID:27626693
PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status. PMID:27626492
Proteomic profiling of human islets collected from frozen pancreata using laser capture microdissection. PMID:27620696
The ever-expanding myokinome: discovery challenges and therapeutic implications. PMID:27616294
Angelman syndrome - insights into a rare neurogenetic disorder. PMID:27615419
Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients. PMID:27612591
Comparative analysis of housekeeping and tissue-specific driver nodes in human protein interaction networks. PMID:27612563
Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor. PMID:27610270
What Signatures Dominantly Associate with Gene Age? PMID:27609935
CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease. PMID:27604409
Putative functions of tissue kallikrein-related peptidases in vaginal fluid. PMID:27603220
Data sources for in vivo molecular profiling of human phenotypes. PMID:27599755
Gene expression of immediate early genes of AP-1 transcription factor in human peripheral blood mononuclear cells in response to ionizing radiation. PMID:27586508
ANGIOGENES: knowledge database for protein-coding and noncoding RNA genes in endothelial cells. PMID:27582018
Detection of Missing Proteins Using the PRIDE Database as a Source of Mass Spectrometry Evidence. PMID:27581094
Pigment epithelium-derived factor (PEDF) normalizes matrix defects in iPSCs derived from Osteogenesis imperfecta Type VI. PMID:27579219
The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation. PMID:27578796
Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules. PMID:27578149
Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder. PMID:27577603
Highlights of the Biology and Disease-driven Human Proteome Project, 2015-2016. PMID:27573249
MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma. PMID:27572323
Mapping the Cell-Surface N-Glycoproteome of Human Hepatocytes Reveals Markers for Selecting a Homogeneous Population of iPSC-Derived Hepatocytes. PMID:27569060
Analysis of ARMC5 expression in human tissues. PMID:27568465
Identification of a novel progenitor cell marker, grainyhead-like 2 in the developing pituitary. PMID:27564454
A Cell-type-resolved Liver Proteome. PMID:27562671
The multi-omic landscape of transcription factor inactivation in cancer. PMID:27562343
Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1. PMID:27556547
Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma. PMID:27545456
Mapping paths: new approaches to dissect eukaryotic signaling circuitry. PMID:27540473
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease. PMID:27532054
Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. PMID:27515689
Pangolin genomes and the evolution of mammalian scales and immunity. PMID:27510566
The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation. PMID:27507887
Genetic mapping of canine fear and aggression. PMID:27503363
A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis. PMID:27503255
The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. PMID:27501152
A Genome-Scale Investigation of How Sequence, Function, and Tree-Based Gene Properties Influence Phylogenetic Inference. PMID:27492233
Prediction of scaffold proteins based on protein interaction and domain architectures. PMID:27490120
Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM). PMID:27489532
Metrics for the Human Proteome Project 2016: Progress on Identifying and Characterizing the Human Proteome, Including Post-Translational Modifications. PMID:27487407
Multiplex matrix network analysis of protein complexes in the human TCR signalosome. PMID:27485017
Association of TGFβ signaling with the maintenance of a quiescent stem cell niche in human oral mucosa. PMID:27480259
Representing and querying disease networks using graph databases. PMID:27462371
Withdrawn: Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. PMID:27454361
Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders. PMID:27453931
Cross-reactivity between annexin A2 and Beta-2-glycoprotein I in animal models of antiphospholipid syndrome. PMID:27449504
Meta-analysis of gene expression profiles identifies differential biomarkers for hepatocellular carcinoma and cholangiocarcinoma. PMID:27448818
The mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy. PMID:27447563
Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition. PMID:27436874
Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use. PMID:27436286
Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study. PMID:27421136
Crowdsourcing biomedical research: leveraging communities as innovation engines. PMID:27418159
Branched multipeptide immunotherapy for glioblastoma using human leukocyte antigen-A*0201-restricted cytotoxic T-lymphocyte epitopes from ERBB2, BIRC5 and CD99. PMID:27409668
Loss of MYC and E-box3 binding contributes to defective MYC-mediated transcriptional suppression of human MC-let-7a-1~let-7d in glioblastoma. PMID:27409345
Delineation of autoantibody repertoire through differential proteogenomics in hepatitis C virus-induced cryoglobulinemia. PMID:27403724
Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks. PMID:27403431
Identification of lung-specific genes by meta-analysis of multiple tissue RNA-seq data. PMID:27398317
Decorin-mediated inhibition of the migration of U87MG glioma cells involves activation of autophagy and suppression of TGF-β signaling. PMID:27398310
Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules. PMID:27385551
Nuclear import sequence identification in hOAS3 protein. PMID:27379722
HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective. PMID:27379525
H11/HSPB8 Restricts HIV-2 Vpx to Restore the Anti-Viral Activity of SAMHD1. PMID:27379031
Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies. PMID:27377311
Computational genomics tools for dissecting tumour-immune cell interactions. PMID:27376489
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. PMID:27374120
Recon 2.2: from reconstruction to model of human metabolism. PMID:27358602
Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels. PMID:27357396
Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells. PMID:27355192
miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy. PMID:27350436
Matricellular TSP-1 as a target of interest for impeding melanoma spreading: towards a therapeutic use for TAX2 peptide. PMID:27349907
P2A-Fluorophore Tagging of BRAF Tightly Links Expression to Fluorescence In Vivo. PMID:27348307
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance. PMID:27345421
Transcriptomic analyses of genes and tissues in inherited sensory neuropathies. PMID:27343803
ImmunoPET for assessing the differential uptake of a CD146-specific monoclonal antibody in lung cancer. PMID:27342417
Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis. PMID:27339464
Beta-3 adrenergic agonists reduce pulmonary vascular resistance and improve right ventricular performance in a porcine model of chronic pulmonary hypertension. PMID:27328822
SRF promotes gastric cancer metastasis through stromal fibroblasts in an SDF1-CXCR4-dependent manner. PMID:27323859
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein. PMID:27323809
Targeted Vaccination against Human α-Lactalbumin for Immunotherapy and Primary Immunoprevention of Triple Negative Breast Cancer. PMID:27322324
Association, characterisation and meta-analysis of SNPs linked to general reading ability in a German dyslexia case-control cohort. PMID:27312598
New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology. PMID:27308565
Advanced Multidimensional Separations in Mass Spectrometry: Navigating the Big Data Deluge. PMID:27306312
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR. PMID:27298316
FOXN3 Regulates Hepatic Glucose Utilization. PMID:27292639
Emergence and Evolution of Hominidae-Specific Coding and Noncoding Genomic Sequences. PMID:27289096
Global, quantitative and dynamic mapping of protein subcellular localization. PMID:27278775
Omics databases on kidney disease: where they can be found and how to benefit from them. PMID:27274817
Association-heterogeneity mapping identifies an Asian-specific association of the GTF2I locus with rheumatoid arthritis. PMID:27272985
Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis. PMID:27264872
ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism. PMID:27260404
Transcriptomic Segregation of Human Autoantigens Useful for the Diagnosis of Autoimmune Diseases. PMID:27259330
A Common Variant at the 14q32 Endometrial Cancer Risk Locus Activates AKT1 through YY1 Binding. PMID:27259051
P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis. PMID:27254077
EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMT. PMID:27253373
Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow. PMID:27250503
The hydrogen sulfide metabolite trimethylsulfonium is found in human urine. PMID:27247020
Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor. PMID:27243554
An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. PMID:27239938
Pigment Epithelium-Derived Factor (PEDF) is a Determinant of Stem Cell Fate: Lessons from an Ultra-Rare Disease. PMID:27239449
Current state of the art for enhancing urine biomarker discovery. PMID:27232439
Data integration to prioritize drugs using genomics and curated data. PMID:27231484
Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria. PMID:27230523
Connexin and pannexin channels in cancer. PMID:27229305
Comparative Proteomic Analysis of Whole-Gut Lavage Fluid and Pancreatic Juice Reveals a Less Invasive Method of Sampling Pancreatic Secretions. PMID:27228405
Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication. PMID:27225481
Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury. PMID:27224670
Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis. PMID:27216817
A novel COL4A1 frameshift mutation in familial kidney disease: the importance of the C-terminal NC1 domain of type IV collagen. PMID:27190376
Emerging role for regulated in development and DNA damage 1 (REDD1) in the regulation of skeletal muscle metabolism. PMID:27189933
Identification of brain-enriched proteins in the cerebrospinal fluid proteome by LC-MS/MS profiling and mining of the Human Protein Atlas. PMID:27186164
Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy. PMID:27185954
Systems-level analysis of human aging genes shed new light on mechanisms of aging. PMID:27179790
Brucella melitensis and Mycobacterium tuberculosis depict overlapping gene expression patterns induced in infected THP-1 macrophages. PMID:27175205
PepPSy: a web server to prioritize gene products in experimental and biocuration workflows. PMID:27173522
Erythropoietin Pathway: A Potential Target for the Treatment of Depression. PMID:27164096
Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response. PMID:27161320
EGFR Activation Leads to Cell Death Independent of PI3K/AKT/mTOR in an AD293 Cell Line. PMID:27153109
Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses. PMID:27152965
Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes. PMID:27152864
The Response of microRNAs to Solar UVR in Skin-Resident Melanocytes Differs between Melanoma Patients and Healthy Persons. PMID:27149382
De novo truncating variants in the AHDC1 gene encoding the AT-hook DNA-binding motif-containing protein 1 are associated with intellectual disability and developmental delay. PMID:27148574
Tetraspanin CD151 Promotes Initial Events in Human Cytomegalovirus Infection. PMID:27147745
NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes. PMID:27144453
Cross-tissue Analysis of Gene and Protein Expression in Normal and Cancer Tissues. PMID:27142790
Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation. PMID:27142428
Five endometrial cancer risk loci identified through genome-wide association analysis. PMID:27135401
Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation. PMID:27127173
Pigment epithelium-derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade. PMID:27127101
BMP2/BMPR1A is linked to tumour progression in dedifferentiated liposarcomas. PMID:27114889
Urate Handling in the Human Body. PMID:27105641
Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners. PMID:27100087
g:Profiler-a web server for functional interpretation of gene lists (2016 update). PMID:27098042
SRC kinase inhibition with saracatinib limits the development of osteolytic bone disease in multiple myeloma. PMID:27095574
Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies. PMID:27094239
HDAC6-mediated EGFR stabilization and activation restrict cell response to sorafenib in non-small cell lung cancer cells. PMID:27090797
Dynamics of Protein Expression Reveals Primary Targets and Secondary Messengers of Estrogen Receptor Alpha Signaling in MCF-7 Breast Cancer Cells. PMID:27067054
Regulating the Rate of Molecular Self-Assembly for Targeting Cancer Cells. PMID:27062481
Clustered mutations in hominid genome evolution are consistent with APOBEC3G enzymatic activity. PMID:27056836
Mouse Sox17 haploinsufficiency leads to female subfertility due to impaired implantation. PMID:27053385
A physiome interoperability roadmap for personalized drug development. PMID:27051513
Specific c-Jun target genes in malignant melanoma. PMID:27050748
Identification of Differentially Expressed Genes through Integrated Study of Alzheimer's Disease Affected Brain Regions. PMID:27050411
PDZ binding kinase (PBK) is a theranostic target for nasopharyngeal carcinoma: driving tumor growth via ROS signaling and correlating with patient survival. PMID:27049917
Genic insights from integrated human proteomics in GeneCards. PMID:27048349
Transcriptomics resources of human tissues and organs. PMID:27044256
Screening of Two ADH4 Variations in a Swedish Cluster Headache Case-Control Material. PMID:27041676
[Caspase-1 regulates autoinflammation in rheumatic diseases]. PMID:27034076
The biology of DHX9 and its potential as a therapeutic target. PMID:27034008
Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome. PMID:27030248
A Systematic Characterization of Aquaporin-9 Expression in Human Normal and Pathological Tissues. PMID:27026296
RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells. PMID:27015414
Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis. PMID:27013584
Small ubiquitin-related modifier 1 is involved in hepatocellular carcinoma progression via mediating p65 nuclear translocation. PMID:26993772
Integrin signalling regulates YAP and TAZ to control skin homeostasis. PMID:26989177
Radioimmunotherapy of prostate cancer targeting human kallikrein-related peptidase 2. PMID:26983637
In silico and experimental analyses predict the therapeutic value of an EZH2 inhibitor GSK343 against hepatocellular carcinoma through the induction of metallothionein genes. PMID:26973856
Rare renal ciliopathies in non-consanguineous families that were identified by targeted resequencing. PMID:26968886
Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition. PMID:26967563
Enzyme-Instructed Self-Assembly of Small D-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells. PMID:26966844
Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma. PMID:26956916
Apolipoprotein L1 and Kidney Disease in African Americans. PMID:26947522
Preeclampsia and Inflammatory Preterm Labor Alter the Human Placental Hematopoietic Niche. PMID:26944948
Reconstruction of Tissue-Specific Metabolic Networks Using CORDA. PMID:26942765
The Predictive Link between Matrix and Metastasis. PMID:26942108
Type 1 diabetes cadaveric human pancreata exhibit a unique exocrine tissue proteomic profile. PMID:26935967
Galectin signatures contribute to the heterogeneity of breast cancer and provide new prognostic information and therapeutic targets. PMID:26933916
The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases. PMID:26924986
Label-free proteomic methodology for the analysis of human kidney stone matrix composition. PMID:26924944
An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer. PMID:26921330
The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis. PMID:26920220
Differential mouse-strain specific expression of Junctional Adhesion Molecule (JAM)-B in placental structures. PMID:26914234
Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease. PMID:26911677
Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases. PMID:26893370
Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer. PMID:26882907
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value. PMID:26877874
Single-cell Transcriptome Study as Big Data. PMID:26876720
Mass spectrometric quantification of salivary metanephrines-A study in healthy subjects. PMID:26874200
Circular RNA profile in gliomas revealed by identification tool UROBORUS. PMID:26873924
Drugging Membrane Protein Interactions. PMID:26863923
Simvastatin Sodium Salt and Fluvastatin Interact with Human Gap Junction Gamma-3 Protein. PMID:26863535
Novel SLC19A3 Promoter Deletion and Allelic Silencing in Biotin-Thiamine-Responsive Basal Ganglia Encephalopathy. PMID:26863430
Anoctamin 2 identified as an autoimmune target in multiple sclerosis. PMID:26862169
Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools. PMID:26858650
Family-wide Structural Analysis of Human Numb-Associated Protein Kinases. PMID:26853940
Benchmarking Procedures for High-Throughput Context Specific Reconstruction Algorithms. PMID:26834640
Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway. PMID:26831087
Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1. PMID:26830021
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. PMID:26829750
PDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δ. PMID:26819372
Unraveling Molecular Differences of Gastric Cancer by Label-Free Quantitative Proteomics Analysis. PMID:26805816
Hyperpolarization-activated cation and T-type calcium ion channel expression in porcine and human renal pacemaker tissues. PMID:26805464
Global analysis of human duplicated genes reveals the relative importance of whole-genome duplicates originated in the early vertebrate evolution. PMID:26801093
The biochemical and mass spectrometric profiling of the dystrophin complexome from skeletal muscle. PMID:26793286
Small Molecule Inhibitors of Protein Arginine Methyltransferases. PMID:26789238
Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes. PMID:26783963
Structural basis and function of XRN2 binding by XTB domains. PMID:26779609
Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine. PMID:26779040
A network analysis of cofactor-protein interactions for analyzing associations between human nutrition and diseases. PMID:26777674
A novel BAP1 mutation is associated with melanocytic neoplasms and thyroid cancer. PMID:26774355
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer. PMID:26771841
Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin. PMID:26771485
ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression. PMID:26771237
Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. PMID:26771213
Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A 686. PMID:26760772
Identifying and functionally characterizing tissue-specific and ubiquitously expressed human lncRNAs. PMID:26760768
Human fallopian tube proteome shows high coverage of mesenchymal stem cells associated proteins. PMID:26759384
miR-185 mediates lung epithelial cell death after oxidative stress. PMID:26747785
Galectins are human milk glycan receptors. PMID:26747425
The 5300-year-old Helicobacter pylori genome of the Iceman. PMID:26744403
Pregnancy in a Patient With Primary Membranous Nephropathy and Circulating Anti-PLA2R Antibodies: A Case Report. PMID:26744127
A proteogenomic approach to understand splice isoform functions through sequence and expression-based computational modeling. PMID:26740460
Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. PMID:26736064
Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics. PMID:26732734
ChainRank, a chain prioritisation method for contextualisation of biological networks. PMID:26729273
New Colors for Histology: Optimized Bivariate Color Maps Increase Perceptual Contrast in Histological Images. PMID:26717571
TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. PMID:26701909
Forward Individualized Medicine from Personal Genomes to Interactomes. PMID:26696898
Meta-analysis of RNA-seq expression data across species, tissues and studies. PMID:26694591
The Urinary Bladder Transcriptome and Proteome Defined by Transcriptomics and Antibody-Based Profiling. PMID:26694548
Identification of significantly mutated regions across cancer types highlights a rich landscape of functional molecular alterations. PMID:26691984
Identification of epistatic interactions through genome-wide association studies in sporadic medullary and juvenile papillary thyroid carcinomas. PMID:26690675
Bioinformatics Mining and Modeling Methods for the Identification of Disease Mechanisms in Neurodegenerative Disorders. PMID:26690135
Fundamentals of protein interaction network mapping. PMID:26681426
Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins. PMID:26678612
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors. PMID:26675378
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. PMID:26673895
Rare copy number variants implicated in posterior urethral valves. PMID:26663319
Circulating protein synthesis rates reveal skeletal muscle proteome dynamics. PMID:26657858
Exome Sequencing Identifies Pathogenic and Modifier Mutations in a Child With Sporadic Dilated Cardiomyopathy. PMID:26656454
Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding. PMID:26651948
Integrating Diverse Types of Genomic Data to Identify Genes that Underlie Adverse Pregnancy Phenotypes. PMID:26641094
Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8. PMID:26637978
Phospholipase C-β1 Hypofunction in the Pathogenesis of Schizophrenia. PMID:26635636
Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer. PMID:26633560
Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants. PMID:26633466
Inhibition Profiling of Retroviral Protease Inhibitors Using an HIV-2 Modular System. PMID:26633459
MERAV: a tool for comparing gene expression across human tissues and cell types. PMID:26626150
Regulation of Murine Ovarian Epithelial Carcinoma by Vaccination against the Cytoplasmic Domain of Anti-Müllerian Hormone Receptor II. PMID:26618181
The Elusive Antifibrotic Macrophage. PMID:26618160
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response. PMID:26597527
Lynx: a knowledge base and an analytical workbench for integrative medicine. PMID:26590263
Developing Potential Candidates of Preclinical Preeclampsia. PMID:26580600
Oncogene-Induced Senescence in Pituitary Adenomas--an Immunohistochemical Study. PMID:26573928
Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila. PMID:26567182
Immunocapture strategies in translational proteomics. PMID:26558424
T-cell receptor gene therapy--ready to go viral? PMID:26548533
Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human. PMID:26545399
Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly. PMID:26538313
The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma. PMID:26526617
Germline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid Cancer. PMID:26522472
CAMUR: Knowledge extraction from RNA-seq cancer data through equivalent classification rules. PMID:26519501
Integrated interactions database: tissue-specific view of the human and model organism interactomes. PMID:26516188
NCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings. PMID:26516186
Multiclassifier combinatorial proteomics of organelle shadows at the example of mitochondria in chromatin data. PMID:26510496
Targeted Therapies in Liver Fibrosis: Combining the Best Parts of Platelet-Derived Growth Factor BB and Interferon Gamma. PMID:26501061
SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin. PMID:26497600
Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues. PMID:26496946
The potential clinical impact of the release of two drafts of the human proteome. PMID:26496066
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. PMID:26493500
Qualitative and Quantitative Protein Complex Prediction Through Proteome-Wide Simulations. PMID:26492574
Establishing the Role of PPARβ/δ in Carcinogenesis. PMID:26490384
An evidence-based knowledgebase of metastasis suppressors to identify key pathways relevant to cancer metastasis. PMID:26486520
Cell biology of the future: Nanometer-scale cellular cartography. PMID:26483557
Expression Atlas update--an integrated database of gene and protein expression in humans, animals and plants. PMID:26481351
Erythropoietin Stimulates Tumor Growth via EphB4. PMID:26481148
Tissue matrix arrays for high-throughput screening and systems analysis of cell function. PMID:26480475
The gut microbiota modulates host amino acid and glutathione metabolism in mice. PMID:26475342
Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver. PMID:26473164
The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer. PMID:26452038
The Hox cluster microRNA miR-615: a case study of intronic microRNA evolution. PMID:26451238
MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins. PMID:26450961
The cytotoxicity of the α1-adrenoceptor antagonist prazosin is linked to an endocytotic mechanism equivalent to transport-P. PMID:26449523
Exploring the potential of public proteomics data. PMID:26449181
HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators. PMID:26447468
Recent insights into the biological functions of liver fatty acid binding protein 1. PMID:26443794
Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins. PMID:26437229
Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue. PMID:26434764
MitoMiner v3.1, an update on the mitochondrial proteomics database. PMID:26432830
Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms. PMID:26431381
Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. PMID:26431332
MicroRNAs in placental health and disease. PMID:26428496
Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry. PMID:26417085
Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons. PMID:26416880
Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes. PMID:26406121
A cultured approach to canine urothelial carcinoma: molecular characterization of five cell lines. PMID:26401343
Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. PMID:26394276
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate. PMID:26388830
mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. PMID:26382858
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook. PMID:26377319
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC. PMID:26377184
'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. PMID:26377085
Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers. PMID:26374119
Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality. PMID:26352407
Human protein interaction networks across tissues and diseases. PMID:26347769
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B. PMID:26344709
Panorama of ancient metazoan macromolecular complexes. PMID:26344197
Prediction and validation of enzyme and transporter off-targets for metformin. PMID:26335661
Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal. PMID:26314964
Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis. PMID:26297835
Chromosome Y genetic variants: impact in animal models and on human disease. PMID:26286457
miR-126-3p Inhibits Thyroid Cancer Cell Growth and Metastasis, and Is Associated with Aggressive Thyroid Cancer. PMID:26244545
A Role for Low Density Lipoprotein Receptor-Related Protein 1 in the Cellular Uptake of Tissue Plasminogen Activator in the Lungs. PMID:26231141
Identification and Validation of Protein Biomarkers of Response to Neoadjuvant Platinum Chemotherapy in Muscle Invasive Urothelial Carcinoma. PMID:26230923
Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models. PMID:26224857
Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer. PMID:26222560
Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. PMID:26220980
STIM and ORAI proteins in the nervous system. PMID:26218135
APOL1 Kidney Disease Risk Variants: An Evolving Landscape. PMID:26215860
MI-PVT: A Tool for Visualizing the Chromosome-Centric Human Proteome. PMID:26204236
Mining Missing Membrane Proteins by High-pH Reverse-Phase StageTip Fractionation and Multiple Reaction Monitoring Mass Spectrometry. PMID:26202522
Mitochondrial genomes are retained by selective constraints on protein targeting. PMID:26195779
Structural Bioinformatics Inspection of neXtProt PE5 Proteins in the Human Proteome. PMID:26193931
Structure alignment of membrane proteins: Accuracy of available tools and a consensus strategy. PMID:26178143
Automated Analysis and Classification of Histological Tissue Features by Multi-Dimensional Microscopic Molecular Profiling. PMID:26176839
Implications of pleiotropy: challenges and opportunities for mining Big Data in biomedicine. PMID:26175753
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. PMID:26168014
THOC2 Mutations Implicate mRNA-Export Pathway in X-Linked Intellectual Disability. PMID:26166480
Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells. PMID:26164207
Pigment epithelium-derived factor as a multifunctional regulator of wound healing. PMID:26163443
The extracellular matrix: Tools and insights for the "omics" era. PMID:26163349
Context-Specific Metabolic Model Extraction Based on Regularized Least Squares Optimization. PMID:26158726
Comprehensive comparison of large-scale tissue expression datasets. PMID:26157623
Matricellular proteins of the Cyr61/CTGF/NOV (CCN) family and the nervous system. PMID:26157362
Metrics for the Human Proteome Project 2015: Progress on the Human Proteome and Guidelines for High-Confidence Protein Identification. PMID:26155816
Association between cell cycle gene transcription and tumor size in oral squamous cell carcinoma. PMID:26152289
Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry. PMID:26150155
Post-translational modifications of the cardiac proteome in diabetes and heart failure. PMID:26140508
Personalized medicine going precise: from genomics to microbiomics. PMID:26129865
OCT1 and imatinib transport in CML: is it clinically relevant? PMID:26122430
Complementing tissue characterization by integrating transcriptome profiling from the Human Protein Atlas and from the FANTOM5 consortium. PMID:26117540
Evolutionary trends and functional anatomy of the human expanded autophagy network. PMID:26103419
Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila. PMID:26098872
Extensive rewiring of epithelial-stromal co-expression networks in breast cancer. PMID:26087699
Defining the Human Brain Proteome Using Transcriptomics and Antibody-Based Profiling with a Focus on the Cerebral Cortex. PMID:26076492
The Levels of a Universally Conserved tRNA Modification Regulate Cell Growth. PMID:26063805
Alternatively Spliced Homologous Exons Have Ancient Origins and Are Highly Expressed at the Protein Level. PMID:26061177
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells. PMID:26022688
DeAnnCNV: a tool for online detection and annotation of copy number variations from whole-exome sequencing data. PMID:26013811
MyProteinNet: build up-to-date protein interaction networks for organisms, tissues and user-defined contexts. PMID:25990735
Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. PMID:25979344
Enzyme-instructed self-assembly: a multistep process for potential cancer therapy. PMID:25933032
Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer. PMID:25903835
Manganese homeostasis and utilization in pathogenic bacteria. PMID:25898914
Psoriatic arthritis under a proteomic spotlight: application of novel technologies to advance diagnosis and management. PMID:25895652
Systems medicine: evolution of systems biology from bench to bedside. PMID:25891169
Assessing the impact of mutations found in next generation sequencing data over human signaling pathways. PMID:25883139
Modelling the effect of SPION size in a stent assisted magnetic drug targeting system with interparticle interactions. PMID:25815370
Role of E2-Ub-conjugating enzymes during skeletal muscle atrophy. PMID:25805999
Affinity proteomics to study endogenous protein complexes: pointers, pitfalls, preferences and perspectives. PMID:25757543
Gene expression: spatial characterization of proteomes. PMID:25668785 -
Towards a knowledge-based Human Protein Atlas
PubMed citations: 911.
911 articles citing: Towards a knowledge-based Human Protein Atlas
Functional lncRNA-miRNA-mRNA Networks in Response to Baicalein Treatment in Hepatocellular Carcinoma. PMID:33511213
Increased placental expression of angiotensin-converting enzyme 2, the receptor of SARS-CoV-2, associated with hypoxia in twin anemia-polycythemia sequence (TAPS). PMID:33497931
SARS-CoV-2 and other human coronavirus: Mapping of protease recognition sites, antigenic variation of spike protein and their grouping through molecular phylogenetics. PMID:33497837
Endogenous Mobilization of Mesenchymal Stromal Cells: A Pathway for Interorgan Communication? PMID:33490065
The Prognostic Impact of Retinoid X Receptor and Thyroid Hormone Receptor alpha in Unifocal vs. Multifocal/Multicentric Breast Cancer. PMID:33478016
Increased expression of CELSR3 indicates a poor prognostic factor for Prostate Cancer. PMID:33442409
Interferon-inducible protein 16 may be a biomarker and prognostic factor in renal cell carcinoma by bioinformatics analysis. PMID:33429832
Exploring gene knockout strategies to identify potential drug targets using genome-scale metabolic models. PMID:33420254
Elucidating the network features and evolutionary attributes of intra- and interspecific protein-protein interactions between human and pathogenic bacteria. PMID:33420198
Circulating MicroRNAs in Relation to Esophageal Adenocarcinoma Diagnosis and Survival. PMID:33403483
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. PMID:33398198
Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure. PMID:33382739
The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells. PMID:33351855
Bioinformatics analysis identifies COL1A1, THBS2 and SPP1 as potential predictors of patient prognosis and immunotherapy response in gastric cancer. PMID:33345281
Tools for the Recognition of Sorting Signals and the Prediction of Subcellular Localization of Proteins From Their Amino Acid Sequences. PMID:33324450
Widespread Aberrant Alternative Splicing despite Molecular Remission in Chronic Myeloid Leukaemia Patients. PMID:33322625
Expression patterns and prognostic values of the cyclin-dependent kinase 1 and cyclin A2 gene cluster in pancreatic adenocarcinoma. PMID:33290118
Overexpression of TPX2 predicts poor clinical outcome and is associated with immune infiltration in hepatic cell cancer. PMID:33285774
Organic Cation Transporters in the Lung-Current and Emerging (Patho)Physiological and Pharmacological Concepts. PMID:33271927
Thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma. PMID:33240428
COVID-19 endocrinopathy with hindsight from SARS. PMID:33236920
Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota. PMID:33208821
Improving target assessment in biomedical research: the GOT-IT recommendations. PMID:33199880
DPPN-SVM: Computational Identification of Mis-Localized Proteins in Cancers by Integrating Differential Gene Expressions With Dynamic Protein-Protein Interaction Networks. PMID:33193746
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. PMID:33147445
The Human Protein Atlas-Spatial localization of the human proteome in health and disease. PMID:33146890
Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function. PMID:33122634
Identification of key genes and pathways for melanoma in the TRIM family. PMID:33118318
Developmental constraint shaped genome evolution and erythrocyte loss in Antarctic fishes following paleoclimate change. PMID:33108368
Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer. PMID:33099724
A high-stringency blueprint of the human proteome. PMID:33067450
Protein-protein and protein-nucleic acid binding residues important for common and rare sequence variants in human. PMID:33050876
Identification of immune checkpoint inhibitors and biomarkers among STAT family in stomach adenocarcinoma. PMID:33042401
The role of herpesvirus 6A and 6B in multiple sclerosis and epilepsy. PMID:33037649
Identification of PLOD Family Genes as Novel Prognostic Biomarkers for Hepatocellular Carcinoma. PMID:33014843
Comprehensive Analysis of the Expression, Relationship to Immune Infiltration and Prognosis of TIM-1 in Cancer. PMID:33014768
Integrative Analysis of Membrane Proteome and MicroRNA Reveals Novel Lung Cancer Metastasis Biomarkers. PMID:33005184
Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development. PMID:32999373
Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics. PMID:32993656
PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer. PMID:32985124
Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries. PMID:32973800
Nutritional Therapy to Modulate Tryptophan Metabolism and Aryl Hydrocarbon-Receptor Signaling Activation in Human Diseases. PMID:32957545
A network pharmacology study on analgesic mechanism of Yuanhu-Baizhi herb pair. PMID:32948176
StoneMod: a database for kidney stone modulatory proteins with experimental evidence. PMID:32934277
Prospective evaluation of the lymph node proteome in dogs with multicentric lymphoma supplemented with sulforaphane. PMID:32926463
Pinpointing Cell Identity in Time and Space. PMID:32923457
Automated classification of protein subcellular localization in immunohistochemistry images to reveal biomarkers in colon cancer. PMID:32907537
SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation. PMID:32905556
Mining Database for the Expression and Clinical Significance of NF-κB Family in Hepatocellular Carcinoma. PMID:32879628
Advances in Astrocyte Computational Models: From Metabolic Reconstructions to Multi-omic Approaches. PMID:32848690
PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation. PMID:32819411
Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane. PMID:32788342
Sexually Dimorphic Crosstalk at the Maternal-Fetal Interface. PMID:32772088
SARS-CoV-2-host dynamics: Increased risk of adverse outcomes of COVID-19 in obesity. PMID:32755835
Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder. PMID:32744794
cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4. PMID:32733276
A Critical Review of Proteomic Studies in Gestational Diabetes Mellitus. PMID:32724825
(Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A. PMID:32718059
Effects of tesamorelin on hepatic transcriptomic signatures in HIV-associated NAFLD. PMID:32701508
Downregulation of LUZP2 Is Correlated with Poor Prognosis of Low-Grade Glioma. PMID:32695826
The prognostic value of leucine-rich repeat-containing G-protein (Lgr5) and its impact on clinicopathological features of colorectal cancer. PMID:32671503
Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells. PMID:32664515
Intellectual Disability and Potassium Channelopathies: A Systematic Review. PMID:32655623
Serine Incorporator 2 (SERINC2) Expression Predicts an Unfavorable Prognosis of Low-Grade Glioma (LGG): Evidence from Bioinformatics Analysis. PMID:32642801
Clinical validation of the novel HDAC6 radiotracer [18F]EKZ-001 in the human brain. PMID:32638097
The transcriptional signature associated with human motile cilia. PMID:32616903
Analysis of Expression and Its Clinical Significance of the Secreted Phosphoprotein 1 in Lung Adenocarcinoma. PMID:32595698
ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance. PMID:32587767
Identification of an immune-related long non-coding RNA signature and nomogram as prognostic target for muscle-invasive bladder cancer. PMID:32579540
Regulation of cellular senescence by eukaryotic members of the FAH superfamily - A role in calcium homeostasis? PMID:32574647
Downregulation of CLCA4 expression is associated with the development and progression of colorectal cancer. PMID:32565987
A Sample Preparation Protocol for High Throughput Immunofluorescence of Suspension Cells on an Adherent Surface. PMID:32564662
Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor. PMID:32546533
Immunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II. PMID:32499873
Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation. PMID:32482897
Personalized whole-body models integrate metabolism, physiology, and the gut microbiome. PMID:32463598
The Role of LIN28-let-7-ARID3B Pathway in Placental Development. PMID:32455665
Urinary proteomics links keratan sulfate degradation and lysosomal enzymes to early type 1 diabetes. PMID:32453760
Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks. PMID:32444848
Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract. PMID:32425701
Blood-derived biomarkers correlate with clinical progression in Duchenne muscular dystrophy. PMID:32390640
Promising diagnostic and prognostic value of six genes in human hepatocellular carcinoma. PMID:32355538
Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche. PMID:32354994
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression. PMID:32326089
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer. PMID:32322170
Consistent RNA sequencing contamination in GTEx and other data sets. PMID:32321923
Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019? PMID:32314868
NCAPG Is a Promising Therapeutic Target Across Different Tumor Types. PMID:32300299
Gene Expression Profiles Identified Novel Urine Biomarkers for Diagnosis and Prognosis of High-Grade Bladder Urothelial Carcinoma. PMID:32292720
TGF-β1 secreted by pancreatic stellate cells promotes stemness and tumourigenicity in pancreatic cancer cells through L1CAM downregulation. PMID:32291413
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review. PMID:32265741
Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex. PMID:32235678
Peroxiredoxins and Immune Infiltrations in Colon Adenocarcinoma: Their Negative Correlations and Clinical Significances, an In Silico Analysis. PMID:32231717
OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine. PMID:32210335
An Integrated Meta-Analysis of Secretome and Proteome Identify Potential Biomarkers of Pancreatic Ductal Adenocarcinoma. PMID:32197468
FAM83A Promotes Lung Cancer Progression by Regulating the Wnt and Hippo Signaling Pathways and Indicates Poor Prognosis. PMID:32195172
Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. PMID:32193359
Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells. PMID:32170109
Fibroblast-specific genome-scale modelling predicts an imbalance in amino acid metabolism in Refsum disease. PMID:32160399
MicroRNA-361-Mediated Inhibition of HSP90 Expression and EMT in Cervical Cancer Is Counteracted by Oncogenic lncRNA NEAT1. PMID:32151082
Development of Potent Forchlorfenuron Analogs and Their Cytotoxic Effect in Cancer Cell Lines. PMID:32094384
Bioinformatics for Renal and Urinary Proteomics: Call for Aggrandization. PMID:32024005
A Unique Regulation Region in the 3' UTR of HLA-G with a Promising Potential. PMID:32019184
An Integrated Model Based on a Six-Gene Signature Predicts Overall Survival in Patients With Hepatocellular Carcinoma. PMID:32010188
A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population. PMID:31975031
Utility of primary cells to examine NPC1 receptor expression in Mops condylurus, a potential Ebola virus reservoir. PMID:31961874
Finding the Keys to the CAR: Identifying Novel Target Antigens for T Cell Redirection Immunotherapies. PMID:31947597
Polycystin 2 is increased in disease to protect against stress-induced cell death. PMID:31941974
Seminal fluid-mediated fitness effects in the simultaneously hermaphroditic flatworm Macrostomum lignano. PMID:31938489
Uncovering the Pharmacological Mechanism of Stemazole in the Treatment of Neurodegenerative Diseases Based on a Network Pharmacology Approach. PMID:31936558
DDX3X Multifunctionally Modulates Tumor Progression and Serves as a Prognostic Indicator to Predict Cancer Outcomes. PMID:31906196
Nuclear up regulation of the BRCA1-associated ubiquitinase BAP1 is associated with tumor aggressiveness in prostate cancers lacking the TMPRSS2:ERG fusion. PMID:31903168
Analysis of Differentially Expressed Genes in Coronary Artery Disease by Integrated Microarray Analysis. PMID:31881747
Genome-Scale Metabolic Modeling with Protein Expressions of Normal and Cancerous Colorectal Tissues for Oncogene Inference. PMID:31881674
An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity. PMID:31852821
Insulin Signaling as a Key Moderator in Myotonic Dystrophy Type 1. PMID:31849810
Relationship between Helicobacter pylori Infection and Plasmacytoid and Myeloid Dendritic Cells in Peripheral Blood and Gastric Mucosa of Children. PMID:31827378
Development of Immature CD4+CD8+T Cells Into Mature CD4+ T Cells Requires Alpha-1 Antitrypsin as Observed by Treatment in HIV-1 Infected and Uninfected Controls. PMID:31824943
Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD. PMID:31805375
HER2, NF-κB, and SATB1 Expression Patterns in Gastric Cancer and Their Correlation with Clinical and Pathological Parameters. PMID:31737131
Downregulation of HDGF inhibits the tumorigenesis of bladder cancer cells by inactivating the PI3K-AKT signaling pathway. PMID:31692549
Tissue-specific expression profiles and positive selection analysis in the tree swallow (Tachycineta bicolor) using a de novo transcriptome assembly. PMID:31676844
ProteomicsDB: a multi-omics and multi-organism resource for life science research. PMID:31665479
4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN. PMID:31660701
MIC_Locator: a novel image-based protein subcellular location multi-label prediction model based on multi-scale monogenic signal representation and intensity encoding strategy. PMID:31655541
Differentially Methylated Super-Enhancers Regulate Target Gene Expression in Human Cancer. PMID:31636280
Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells. PMID:31611601
In silico approach to calculate the transcript capacity. PMID:31610627
High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer. PMID:31606028
Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis. PMID:31602402
MicroRNA-424 regulates cisplatin resistance of gastric cancer by targeting SMURF1 based on GEO database and primary validation in human gastric cancer tissues. PMID:31571913
The CLN3 gene and protein: What we know. PMID:31568712
DHPS-dependent hypusination of eIF5A1/2 is necessary for TGFβ/fibronectin-induced breast cancer metastasis and associates with prognostically unfavorable genomic alterations in TP53. PMID:31558321
miR-205-5p inhibits human endometriosis progression by targeting ANGPT2 in endometrial stromal cells. PMID:31547870
Enabling Web-scale data integration in biomedicine through Linked Open Data. PMID:31531395
Unsupervised machine learning using an imaging mass spectrometry dataset automatically reassembles grey and white matter. PMID:31519997
Aberrant Regulation of RAD51 Promotes Resistance of Neoadjuvant Endocrine Therapy in ER-positive Breast Cancer. PMID:31506496
HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. PMID:31500569
Downregulation of POFUT1 Impairs Secondary Myogenic Fusion Through a Reduced NFATc2/IL-4 Signaling Pathway. PMID:31500188
Breakdown of multiple sclerosis genetics to identify an integrated disease network and potential variant mechanisms. PMID:31482761
DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases. PMID:31467668
Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer. PMID:31467540
WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. PMID:31462314
Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy. PMID:31452838
Divide and conquer: two stem cell populations in squamous epithelia, reserves and the active duty forces. PMID:31451683
Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination. PMID:31437751
Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown. PMID:31434788
Inter-organ communication: a gatekeeper for metabolic health. PMID:31423716
Bringing Microscopy-By-Sequencing into View. PMID:31416630
Characterization of the prognostic values of the NDRG family in gastric cancer. PMID:31384305
Directed evolution as a tool for the selection of oncolytic RNA viruses with desired phenotypes. PMID:31372363
Decreased expression of SLC16A12 mRNA predicts poor prognosis of patients with clear cell renal cell carcinoma. PMID:31348313
The diagnostic and prognostic role of RhoA in hepatocellular carcinoma. PMID:31339860
Anticancer Immunotherapy by MFAP5 Blockade Inhibits Fibrosis and Enhances Chemosensitivity in Ovarian and Pancreatic Cancer. PMID:31332047
Structures of three ependymin-related proteins suggest their function as a hydrophobic molecule binder. PMID:31316816
Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes. PMID:31282863
Co-expression network analysis identified candidate biomarkers in association with progression and prognosis of breast cancer. PMID:31280346
In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes. PMID:31265809
A Circulating Tumor Cell-RNA Assay for Assessment of Androgen Receptor Signaling Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer. PMID:31244925
In silico Prediction of Human Secretory Proteins in Plasma Based on Discrete Firefly Optimization and Application to Cancer Biomarkers Identification. PMID:31244885
In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR. PMID:31244651
mTOR Signaling Pathway Regulates Sperm Quality in Older Men. PMID:31234465
MPZL1 promotes tumor cell proliferation and migration via activation of Src kinase in ovarian cancer. PMID:31233194
p73 regulates epidermal wound healing and induced keratinocyte programming. PMID:31216312
An expanded proteome of cardiac t-tubules. PMID:31202980
In Depth Quantification of Extracellular Matrix Proteins from Human Pancreas. PMID:31200599
Current status and applications of genome-scale metabolic models. PMID:31196170
A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation. PMID:31172184
pH and male fertility: making sense on pH homeodynamics throughout the male reproductive tract. PMID:31165202
Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics. PMID:31149033
Exploiting orthology and de novo transcriptome assembly to refine target sequence information. PMID:31122257
Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells. PMID:31068932
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease. PMID:31061469
The SUMO-Specific Protease Senp2 Regulates SUMOylation, Expression and Function of Human Organic Anion Transporter 3. PMID:31054272
SNW1 is a prognostic biomarker in prostate cancer. PMID:31043167
Expression of LAIR-1 (CD305) on Human Blood Monocytes as a Marker of Hepatic Cirrhosis Progression. PMID:31019980
YAP-independent mechanotransduction drives breast cancer progression. PMID:31015465
Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway. PMID:31001122
Crystal structure of human RIOK2 bound to a specific inhibitor. PMID:30991936
Overexpression of PARPBP Correlates with Tumor Progression and Poor Prognosis in Hepatocellular Carcinoma. PMID:30949905
Bioinformatics analysis of the prognostic value of CCT6A and associated signalling pathways in breast cancer. PMID:30942452
Multifactorial Contribution of Notch Signaling in Head and Neck Squamous Cell Carcinoma. PMID:30917608
Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis. PMID:30906868
Peroxiporins in Cancer. PMID:30893772
Respiratory dysfunction following initiation of mirabegron: A case report. PMID:30886821
Expression of zinc finger transcription factors (ZNF143 and ZNF281) in serous borderline ovarian tumors and low-grade ovarian cancers. PMID:30885238
Identification of Important Effector Proteins in the FOXJ1 Transcriptional Network Associated With Ciliogenesis and Ciliary Function. PMID:30881373
Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer. PMID:30875794
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy. PMID:30873179
GenTree, an integrated resource for analyzing the evolution and function of primate-specific coding genes. PMID:30862647
Increased LGALS3 expression independently predicts shorter overall survival in patients with the proneural subtype of glioblastoma. PMID:30848102
Evolutionary constraints on the complexity of genetic regulatory networks allow predictions of the total number of genetic interactions. PMID:30842463
Phosphorylation of a Conserved Tyrosine in the Papillomavirus E2 Protein Regulates Brd4 Binding and Viral Replication. PMID:30842331
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion. PMID:30836712
Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior. PMID:30814913
Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells. PMID:30810435
Pancreatic acinar differentiation is guided by differential laminin deposition. PMID:30804366
UBTD1 is a mechano-regulator controlling cancer aggressiveness. PMID:30804013
Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren's syndrome differ in molecular signatures and treatment perspectives. PMID:30777133
If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease. PMID:30775245
Overexpression of BUB1B, CCNA2, CDC20, and CDK1 in tumor tissues predicts poor survival in pancreatic ductal adenocarcinoma. PMID:30765611
Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG2M Phase. PMID:30759381
Programmable RNA detection with a fluorescent RNA aptamer using optimized three-way junction formation. PMID:30745364
CENPE expression is associated with its DNA methylation status in esophageal adenocarcinoma and independently predicts unfavorable overall survival. PMID:30716092
Expression and clinical significance of basic transcription factor 3 in nasopharyngeal carcinoma. PMID:30655831
A model to predict the function of hypothetical proteins through a nine-point classification scoring schema. PMID:30621574
A region-resolved mucosa proteome of the human stomach. PMID:30604760
Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus. PMID:30591584
Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner. PMID:30567987
A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase. PMID:30563079
Integrin Subunit beta 8 (ITGB8) Upregulation Is an Independent Predictor of Unfavorable Survival of High-Grade Serous Ovarian Carcinoma Patients. PMID:30531684
Stable-protein Pair Analysis as A Novel Strategy to Identify Proteomic Signatures: Application To Seminal Plasma From Infertile Patients. PMID:30518674
Integrated Identification and Quantification Error Probabilities for Shotgun Proteomics. PMID:30482846
TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression. PMID:30479348
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. PMID:30476243
Assembly of a parts list of the human mitotic cell cycle machinery. PMID:30452682
miRNA Mediated Noise Making of 3'UTR Mutations in Cancer. PMID:30424545
Cancer-Associated Function of 2-Cys Peroxiredoxin Subtypes as a Survival Gatekeeper. PMID:30423872
Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma. PMID:30419838
Exploring Seipin: From Biochemistry to Bioinformatics Predictions. PMID:30402103
HAVCR1 expression might be a novel prognostic factor for gastric cancer. PMID:30388143
Effect of equiaxial cyclic strain on cardiomyogenic induction in mesenchymal stem cells. PMID:30367393
Salvianolic acid A targeting the transgelin-actin complex to enhance vasoconstriction. PMID:30361065
Targeted Analysis of Serum Proteins Encoded at Known Inflammatory Bowel Disease Risk Loci. PMID:30358838
Druggability of Coronary Artery Disease Risk Loci. PMID:30354342
Genetic expression profile-based screening of genes and pathways associated with papillary thyroid carcinoma. PMID:30344727
Impact of chemotactic factors and receptors on the cancer immune infiltrate: a bioinformatics study revealing homogeneity and heterogeneity among patient cohorts. PMID:30288345
Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes. PMID:30250408
Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer. PMID:30237737
Drug Repurposing of Metabolic Agents in Malignant Glioma. PMID:30223473
Identification of Key Pathways and Genes in Anaplastic Thyroid Carcinoma via Integrated Bioinformatics Analysis. PMID:30213925
Protein fishing from single live cells. PMID:30205820
A Computational Method for Classifying Different Human Tissues with Quantitatively Tissue-Specific Expressed Genes. PMID:30205473
In vitro evaluation of dual-antigenic PV1 peptide vaccine in head and neck cancer patients. PMID:30193086
Hypoxia-inducible transgelin 2 selects epithelial-to-mesenchymal transition and γ-radiation-resistant subtypes by focal adhesion kinase-associated insulin-like growth factor 1 receptor activation in non-small-cell lung cancer cells. PMID:30191639
Cross-tissue eQTL enrichment of associations in schizophrenia. PMID:30188921
Meta-analysis of exome array data identifies six novel genetic loci for lung function. PMID:30175238
Deep learning is combined with massive-scale citizen science to improve large-scale image classification. PMID:30125267
Molecular Approaches to Safe and Controlled Engineered T-cell Therapy. PMID:30116611
Identification of pathways and genes associated with cerebral palsy. PMID:30109564
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms. PMID:30101371
KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control. PMID:30061100
Toward mapping the human body at a cellular resolution. PMID:30058989
Characterization of FGD5 Expression in Primary Breast Cancers and Lymph Node Metastases. PMID:30052477
Microarray gene expression profiling in colorectal (HCT116) and hepatocellular (HepG2) carcinoma cell lines treated with Melicope ptelefolia leaf extract reveals transcriptome profiles exhibiting anticancer activity. PMID:30042885
Global Interactomics Uncovers Extensive Organellar Targeting by Zika Virus. PMID:30037810
Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer. PMID:29975776
Expression of 4E-BP1 and phospho-4E-BP1 correlates with the prognosis of patients with clear cell renal carcinoma. PMID:29942157
Papillomavirus E2 protein is regulated by specific fibroblast growth factor receptors. PMID:29885490
Fibroblasts in the Tumor Microenvironment: Shield or Spear? PMID:29883428
Understanding the seminal plasma proteome and its role in male fertility. PMID:29881623
Upregulation of KIF26B, Cell Migration and Proliferation of Human Ovarian Cancer Cell Lines In Vitro, and Patient Outcomes from Human Bioinformatic Analysis. PMID:29880787
Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions-benign adenomas and inflammatory bowel disease. PMID:29875879
Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models. PMID:29856687
Increased GOLM1 Expression Independently Predicts Unfavorable Overall Survival and Recurrence-Free Survival in Lung Adenocarcinoma. PMID:29843532
Proteomic and bioinformatic discovery of biomarkers for diabetic nephropathy. PMID:29805343
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology. PMID:29784938
Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease. PMID:29782846
CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. PMID:29763414
Aberrant S100A16 expression might be an independent prognostic indicator of unfavorable survival in non-small cell lung adenocarcinoma. PMID:29746588
Transcellular transport of cobalamin in aortic endothelial cells. PMID:29741927
Comparative Analysis of Human Genes Frequently and Occasionally Regulated by m6A Modification. PMID:29730206
Genome sequencing in the clinic: the past, present, and future of genomic medicine. PMID:29727589
Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer. PMID:29723302
A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. PMID:29719227
Profiling plasma extracellular vesicle by pluronic block-copolymer based enrichment method unveils features associated with breast cancer aggression, metastasis and invasion. PMID:29696079
Integrated bioinformatics analysis reveals key candidate genes and pathways in breast cancer. PMID:29693125
Cross-species inference of long non-coding RNAs greatly expands the ruminant transcriptome. PMID:29690875
Cardiomyocytes have mosaic patterns of protein expression. PMID:29677652
CTGF/VEGFA-activated Fibroblasts Promote Tumor Migration Through Micro-environmental Modulation. PMID:29669735
[Value of CHCHD2 as a potential marker of non-small cell lung cancer: analysis of 60 cases]. PMID:29643040
A Protein Standard That Emulates Homology for the Characterization of Protein Inference Algorithms. PMID:29631402
TISSUES 2.0: an integrative web resource on mammalian tissue expression. PMID:29617745
Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancer. PMID:29568088
Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions. PMID:29514827
Streptococcus pyogenes Infection and the Human Proteome with a Special Focus on the Immunoglobulin G-cleaving Enzyme IdeS. PMID:29511047
CDCA5 regulates proliferation in hepatocellular carcinoma and has potential as a negative prognostic marker. PMID:29503564
Carbonic Anhydrases: Role in pH Control and Cancer. PMID:29495652
The Gene-Centric Content Management System and Its Application for Cognitive Proteomics. PMID:29473895
CGB5 expression is independently associated with poor overall survival and recurrence-free survival in patients with advanced gastric cancer. PMID:29473345
A cell death assay for assessing the mitochondrial targeting of proteins. PMID:29454998
Tumor microenvironment heterogeneity: challenges and opportunities. PMID:29430386
Peptide Level Turnover Measurements Enable the Study of Proteoform Dynamics. PMID:29414762
Ascending the PEAK1 toward targeting TGFβ during cancer progression: Recent advances and future perspectives. PMID:29392163
Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer. PMID:29382334
Fragility Extraordinaire: Unsolved Mysteries of Chromosome Fragile Sites. PMID:29357071
Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody. PMID:29356983
Dynamic changes in copper homeostasis and post-transcriptional regulation of Atp7a during myogenic differentiation. PMID:29333545
Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells. PMID:29297499
ASAP3 regulates microvilli structure in parietal cells and presents intervention target for gastric acidity. PMID:29263912
Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective. PMID:29258237
Biotinylation by antibody recognition-a method for proximity labeling. PMID:29256494
Rho GDP dissociation inhibitor-β in renal cell carcinoma. PMID:29250194
Transcription and Remodeling Produce Asymmetrically Unwrapped Nucleosomal Intermediates. PMID:29225036
Annotating gene sets by mining large literature collections with protein networks. PMID:29218918
Neovascular Prostate-Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma. PMID:29209626
Diagnostic significance and potential function of miR-338-5p in hepatocellular carcinoma: A bioinformatics study with microarray and RNA sequencing data. PMID:29207053
Identification of hub miRNA biomarkers for bladder cancer by weighted gene coexpression network analysis. PMID:29200870
Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling. PMID:29187877
Tumoral ANXA1 Is a Predictive Marker for Sunitinib Treatment of Renal Cancer Patients. PMID:29187872
Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations. PMID:29162437
LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness. PMID:29137369
Prognostic microRNAs and their potential molecular mechanism in pancreatic cancer: A study based on The Cancer Genome Atlas and bioinformatics investigation. PMID:29115476
NLSdb-major update for database of nuclear localization signals and nuclear export signals. PMID:29106588
High SLC4A11 expression is an independent predictor for poor overall survival in grade 3/4 serous ovarian cancer. PMID:29091960
TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules. PMID:29088312
Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP). PMID:29059175
CR2Cancer: a database for chromatin regulators in human cancer. PMID:29036683
The SysteMHC Atlas project. PMID:28985418
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. PMID:28977666
Nuclear speckles: molecular organization, biological function and role in disease. PMID:28977640
IMOTA: an interactive multi-omics tissue atlas for the analysis of human miRNA-target interactions. PMID:28977416
Kinase-templated abiotic reaction. PMID:28970898
Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis. PMID:28962592
The human protein atlas: A spatial map of the human proteome. PMID:28940711
In situ protein detection with enhanced specificity using DNA-conjugated antibodies and proximity ligation. PMID:28937142
CellNetVis: a web tool for visualization of biological networks using force-directed layout constrained by cellular components. PMID:28929969
Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling. PMID:28925397
The SubCons webserver: A user friendly web interface for state-of-the-art subcellular localization prediction. PMID:28901589
Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in Trypanosoma brucei. PMID:28887303
Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. PMID:28878041
ITGA1 is a pre-malignant biomarker that promotes therapy resistance and metastatic potential in pancreatic cancer. PMID:28855593
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. PMID:28812582
Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth. PMID:28794006
Kinase Activity of Fibroblast Growth Factor Receptor 3 Regulates Activity of the Papillomavirus E2 Protein. PMID:28768864
Interleukin-17C in Human Helicobacter pylori Gastritis. PMID:28739826
Combined deletion and DNA methylation result in silencing of FAM107A gene in laryngeal tumors. PMID:28710449
Crosstalk and the evolvability of intracellular communication. PMID:28691706
Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway. PMID:28674149
Downregulation of adaptor protein MyD88 compromises the angiogenic potential of B16 murine melanoma. PMID:28662055
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. PMID:28659575
Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity. PMID:28625833
Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines. PMID:28621943
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. PMID:28530674
GeMSTONE: orchestrated prioritization of human germline mutations in the cloud. PMID:28521008
Pro-necrotic molecules impact local immunosurveillance in human breast cancer. PMID:28507808
Serological Epithelial Component Proteins Identify Intestinal Complications in Crohn's Disease. PMID:28490445
Multi-omics approaches to disease. PMID:28476144
Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma. PMID:28445125
Social Behavior of Pet Dogs Is Associated with Peripheral OXTR Methylation. PMID:28443051
Quantitative diagnosis of breast tumors by morphometric classification of microenvironmental myoepithelial cells using a machine learning approach. PMID:28440283
B Cell Tolerance to Deiminated Histones in BALB/c, C57BL/6, and Autoimmune-Prone Mouse Strains. PMID:28424695
Tetraspanin 8 (TSPAN 8) as a potential target for radio-immunotherapy of colorectal cancer. PMID:28423546
Machine learning in computational biology to accelerate high-throughput protein expression. PMID:28398465
High-confidence coding and noncoding transcriptome maps. PMID:28396519
Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein Interactions. PMID:28385878
Expression and clinical value of EGFR in human meningiomas. PMID:28367377
Eosinophilic Esophagitis: A Primary Disease of the Esophageal Mucosa. PMID:28363400
ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. PMID:28351972
A quantitative method for screening and identifying molecular targets for nanomedicine. PMID:28341549
Genotype-based gene signature of glioma risk. PMID:28339748
A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis. PMID:28330499
Extracellular Proton Concentrations Impacts LN229 Glioblastoma Tumor Cell Fate via Differential Modulation of Surface Lipids. PMID:28299282
Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer. PMID:28290516
Discovery of circulating proteins associated to knee radiographic osteoarthritis. PMID:28273936
Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway. PMID:28258213
Use of Aleuria alantia Lectin Affinity Chromatography to Enrich Candidate Biomarkers from the Urine of Patients with Bladder Cancer. PMID:28248271
"Omics"-Informed Drug and Biomarker Discovery: Opportunities, Challenges and Future Perspectives. PMID:28248238
Transcriptomic comparison of primary bovine horn core carcinoma culture and parental tissue at early stage. PMID:28246447
A method for characterizing phenotypic changes in highly variable cell populations and its application to high content screening of Arabidopsis thaliana protoplasts. PMID:28245335
A concept for holistic whole body MRI data analysis, Imiomics. PMID:28241015
Human Nup98 regulates the localization and activity of DExH/D-box helicase DHX9. PMID:28221134
ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms? PMID:28220105
A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels. PMID:28194012
Evaluation of [18F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer. PMID:28157626
Identifying the missing proteins in human proteome by biological language model. PMID:28155671
Correlated 5-Hydroxymethylcytosine (5hmC) and Gene Expression Profiles Underpin Gene and Organ-Specific Epigenetic Regulation in Adult Mouse Brain and Liver. PMID:28125731
The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis. PMID:28114279
Peroxiporin Expression Is an Important Factor for Cancer Cell Susceptibility to Therapeutic H2O2: Implications for Pharmacological Ascorbate Therapy. PMID:28107421
Lysozyme association with circulating RNA, extracellular vesicles, and chronic stress. PMID:28053879
Mutations in BOREALIN cause thyroid dysgenesis. PMID:28025328
MetaboSignal: a network-based approach for topological analysis of metabotype regulation via metabolic and signaling pathways. PMID:28011775
New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells. PMID:28009074
Recon2Neo4j: applying graph database technologies for managing comprehensive genome-scale networks. PMID:27993779
Characterization of glomerular extracellular matrix by proteomic analysis of laser-captured microdissected glomeruli. PMID:27988214
Salivary and pellicle proteome: A datamining analysis. PMID:27966577
Functional Analyses of the Crohn's Disease Risk Gene LACC1. PMID:27959965
An Optimized Chromatographic Strategy for Multiplexing In Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases. PMID:27940637
Three-Dimensionally Functionalized Reverse Phase Glycoprotein Array for Cancer Biomarker Discovery and Validation. PMID:27933927
In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. PMID:27927684
Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome. PMID:27923875
Maximising the potential of AKT inhibitors as anti-cancer treatments. PMID:27919797
Hepatocarcinogenesis in transgenic mice carrying hepatitis B virus pre-S/S gene with the sW172* mutation. PMID:27918551
Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up. PMID:27901618
The neXtProt knowledgebase on human proteins: 2017 update. PMID:27899619
Physiologically-based modeling to predict the clinical behavior of monoclonal antibodies directed against lymphocyte antigens. PMID:27892793
SNAP23 promotes the malignant process of ovarian cancer. PMID:27855700
Quantitative GTPase Affinity Purification Identifies Rho Family Protein Interaction Partners. PMID:27852748
Expression Data Analysis for the Identification of Potential Biomarker of Pregnancy Associated Breast Cancer. PMID:27832451
In Silico Analysis Validates Proteomic Findings of Formalin-fixed Paraffin Embedded Cutaneous Squamous Cell Carcinoma Tissue. PMID:27807068
Molecular mechanisms underlying COPD-muscle dysfunction unveiled through a systems medicine approach. PMID:27794560
Identification of internalin-A-like virulent proteins in Leishmania donovani. PMID:27765050
Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma. PMID:27764136
Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer. PMID:27723779
Proteomic Analysis of Non-depleted Serum Proteins from Bottlenose Dolphins Uncovers a High Vanin-1 Phenotype. PMID:27667588
Using reverse-phase protein arrays as pharmacodynamic assays for functional proteomics, biomarker discovery, and drug development in cancer. PMID:27663479
Genomic characterization of liver metastases from colorectal cancer patients. PMID:27662660
PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide. PMID:27661404
Mitochondrial CHCHD-Containing Proteins: Physiologic Functions and Link with Neurodegenerative Diseases. PMID:27631878
Study of apoptosis-related interactions in colorectal cancer. PMID:27629291
Long-term outcome in young women with breast cancer: a population-based study. PMID:27624330
Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study. PMID:27594614
Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma. PMID:27588472
Complex Sources of Variation in Tissue Expression Data: Analysis of the GTEx Lung Transcriptome. PMID:27588449
Decreased expression of stomatin predicts poor prognosis in HER2-positive breast cancer. PMID:27577936
Mapping the Cell-Surface N-Glycoproteome of Human Hepatocytes Reveals Markers for Selecting a Homogeneous Population of iPSC-Derived Hepatocytes. PMID:27569060
Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment. PMID:27558259
Exaptation of Bornavirus-Like Nucleoprotein Elements in Afrotherians. PMID:27518265
Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin. PMID:27484226
Association of TGFβ signaling with the maintenance of a quiescent stem cell niche in human oral mucosa. PMID:27480259
Truncating Mutations in the Adhesion G Protein-Coupled Receptor G2 Gene ADGRG2 Cause an X-Linked Congenital Bilateral Absence of Vas Deferens. PMID:27476656
Integrative Analysis of Microarray Data to Reveal Regulation Patterns in the Pathogenesis of Hepatocellular Carcinoma.