Human Protein Atlas
Names
More detailed information about this field from each metasource.
Human Protein Atlas
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
HPA
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
The Human Protein Atlas
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
proteinatlas
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
Names
More detailed information about this field from each metasource.
Human Protein Atlas
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
HPA
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
The Human Protein Atlas
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
proteinatlas
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:04.256341
Other names: HPA, The Human Protein Atlas, proteinatlas
Names
More detailed information about this field from each metasource.
Human Protein Atlas
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
HPA
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
The Human Protein Atlas
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
proteinatlas
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:04.256341
The Human Protein Atlas is program started with the aim to map of all the human proteins in cells, tissues and organs using integration of various omics technologies. It consists of three parts: Tissue Atlas showing the distribution of proteins across tissues and organs in the human body, the Cell Atlas showing the subcellular localization of proteins in single cells and Pathology Atlas showing the impact of protein levels for survival of patients with cancer.
Description
More detailed information about this field from each metasource.
The Human Protein Atlas is program started with the aim to map of all the human proteins in cells, tissues and organs using integration of various omics technologies. It consists of three parts: Tissue Atlas showing the distribution of proteins across tissues and organs in the human body, the Cell Atlas showing the subcellular localization of proteins in single cells and Pathology Atlas showing the impact of protein levels for survival of patients with cancer.
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
The Human Protein Atlas (HPA) portal is a publicly available database with millions of high-resolution images showing the spatial distribution of proteins in a number of different wild-type tissues, cancer types and human cell lines. The goal of the HPA is to map all the human proteins in cells, tissues and organs using an integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics and systems biology. The HPA is composed of six parts: the Tissue Atlas, the Single Cell Type Atlas, the Pathology Atlas, the Blood Atlas, the Brain Atlas, and the Cell Atlas.
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
The Swedish Human Protein Atlas project has been set up to allow for a systematic exploration of the human proteome using Antibody-Based Proteomics. This is accomplished by combining high-throughput generation of affinity-purified antibodies with protein profiling in a multitude of tissues and cells assembled in tissue microarrays. Confocal microscopy analysis using human cell lines is performed for more detailed protein localization. The program hosts the Human Protein Atlas portal with expression profiles of human proteins in tissues and cells. The main objective of the resource centre is to produce specific antibodies to human target proteins using a high-throughput production method involving the cloning and protein expression of Protein Epitope Signature Tags (PrESTs). After purification, the antibodies are used to study expression profiles in cells and tissues and for functional analysis of the corresponding proteins in a wide range of platforms.
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
Database with millions of high-resolution images. Expression and localization of proteins in a large variety of normal human tissues, cancer cells and cell lines with the aid of immunohistochemistry (IHC) images and immunofluorescence (IF) confocal microscopy images.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:04.256341
Webpage:
https://www.proteinatlas.orgWebpage
More detailed information about this field from each metasource.
https://www.proteinatlas.org
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
https://www.proteinatlas.org/
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
http://www.proteinatlas.org/
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:04.256341
Licence:
Name: Creative Commons Attribution-ShareAlike v3.0Licence name
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Creative Commons Attribution-ShareAlike v3.0
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
Creative Commons Attribution-ShareAlike 3.0 Unported (CC BY-SA 3.0)
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
other
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
Licence URL
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https://www.proteinatlas.org/about/licence
metasource: BiŌkeanós-Medsourcingversion: 0.0.1:2022-11-04T13:34:25.975929
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
https://creativecommons.org/licenses/by-sa/3.0/
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Publications:
(9)
Publications
More detailed information about this field from each metasource.
Proteomics. Tissue-based map of the human proteome
PMID: 25613900
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A pathology atlas of the human cancer transcriptome
PMID: 28818916
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Towards a knowledge-based Human Protein Atlas
PMID: 21139605
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A subcellular map of the human proteome
PMID: 28495876
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A human protein atlas for normal and cancer tissues based on antibody proteomics
PMID: 16127175
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
The Human Protein Atlas--a tool for pathology
PMID: 18853439
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A genecentric Human Protein Atlas for expression profiles based on antibodies
PMID: 18669619
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Transcriptomics resources of human tissues and organs
PMID: 27044256
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
http://dx.doi.org/10.1126/science.1260419
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
Publications
More detailed information about this field from each metasource.
Proteomics. Tissue-based map of the human proteome
PMID: 25613900
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A pathology atlas of the human cancer transcriptome
PMID: 28818916
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Towards a knowledge-based Human Protein Atlas
PMID: 21139605
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A subcellular map of the human proteome
PMID: 28495876
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A human protein atlas for normal and cancer tissues based on antibody proteomics
PMID: 16127175
metasource: BiŌkeanós-Medsourcing
version: 0.0.1:2022-11-04T13:34:25.975929
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
The Human Protein Atlas--a tool for pathology
PMID: 18853439
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
A genecentric Human Protein Atlas for expression profiles based on antibodies
PMID: 18669619
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Transcriptomics resources of human tissues and organs
PMID: 27044256
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
http://dx.doi.org/10.1126/science.1260419
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:04.256341
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Proteomics. Tissue-based map of the human proteome
PubMed citations: 4857.
4857 articles citing: Proteomics. Tissue-based map of the human proteome
Neuro-oncological Ventral Antigen 2 Regulates Splicing of Vascular Endothelial Growth Factor Receptor 1 and Is Required for Endothelial Function. PMID:35927413
Game-theoretic link relevance indexing on genome-wide expression dataset identifies putative salient genes with potential etiological and diapeutics role in colorectal cancer. PMID:35927308
Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH). PMID:35927268
Gene Identification and Potential Drug Therapy for Drug-Resistant Melanoma with Bioinformatics and Deep Learning Technology. PMID:35915735
The Quest for Anti-α-Synuclein Antibody Specificity-Lessons Learnt From Flow Cytometry Analysis. PMID:35911883
Identification of the KCNQ1OT1/ miR-378a-3p/ RBMS1 Axis as a Novel Prognostic Biomarker Associated With Immune Cell Infiltration in Gastric Cancer. PMID:35910231
Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature. PMID:35907972
Gene networks under circadian control exhibit diurnal organization in primate organs. PMID:35906476
Mutations in SORL1 and MTHFDL1 possibly contribute to the development of Alzheimer's disease in a multigenerational Colombian Family. PMID:35905044
Network Embedding Across Multiple Tissues and Data Modalities Elucidates the Context of Host Factors Important for COVID-19 Infection. PMID:35903362
Multi-Omics Interdisciplinary Research Integration to Accelerate Dementia Biomarker Development (MIRIADE). PMID:35903119
Overexpression of OAS1 Is Correlated With Poor Prognosis in Pancreatic Cancer. PMID:35898870
Shared Genetics and Causality Between Decaffeinated Coffee Consumption and Neuropsychiatric Diseases: A Large-Scale Genome-Wide Cross-Trait Analysis and Mendelian Randomization Analysis. PMID:35898629
A Four-Cell-Senescence-Regulator-Gene Prognostic Index Verified by Genome-Wide CRISPR Can Depict the Tumor Microenvironment and Guide Clinical Treatment of Bladder Cancer. PMID:35898492
GRHL2 Expression Functions in Breast Cancer Aggressiveness and Could Serve as Prognostic and Diagnostic Biomarker for Breast Cancer. PMID:35898391
Phenotypic, metabolic, and biogenesis properties of human stem cell-derived cerebellar spheroids. PMID:35896708
HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance. PMID:35892859
Biological interacting units identified in human protein networks reveal tissue-functional diversification and its impact on disease. PMID:35891788
Biodistribution and Cellular Internalization of Inactivated SARS-CoV-2 in Wild-Type Mice. PMID:35886958
Large-Scale Multi-Omics Studies Provide New Insights into Blood Pressure Regulation. PMID:35886906
Novel Genetic Diagnoses in Septo-Optic Dysplasia. PMID:35885948
The Involvement of Polyamines Catabolism in the Crosstalk between Neurons and Astrocytes in Neurodegeneration. PMID:35885061
Fibrinogen, Fibrinogen-like 1 and Fibrinogen-like 2 Proteins, and Their Effects. PMID:35885017
Downregulation of STAT3 in Epstein-Barr Virus-Positive Hodgkin Lymphoma. PMID:35884913
CDK Inhibition Primes for Anti-PD-L1 Treatment in Triple-Negative Breast Cancer Models. PMID:35884422
An Integrated Bioinformatics Analysis towards the Identification of Diagnostic, Prognostic, and Predictive Key Biomarkers for Urinary Bladder Cancer. PMID:35884419
Genetic Factors Associated with Response to Vitamin E Treatment in NAFLD. PMID:35883775
Opioids and Vitamin C: Known Interactions and Potential for Redox-Signaling Crosstalk. PMID:35883757
Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions. PMID:35882856
Mechanism Study of Proteins under Membrane Environment. PMID:35877897
Retinoschisin and novel Na/K-ATPase interaction partners Kv2.1 and Kv8.2 define a growing protein complex at the inner segments of mammalian photoreceptors. PMID:35876901
Deciphering Prognostic Value of TTN and Its Correlation With Immune Infiltration in Lung Adenocarcinoma. PMID:35875159
KCC3a, a Strong Candidate Pathway for K+ Loss in Alkalemia. PMID:35874803
Integrative Analysis From Multicenter Studies Identifies a WGCNA-Derived Cancer-Associated Fibroblast Signature for Ovarian Cancer. PMID:35874760
Single-cell sorting based on secreted products for functionally defined cell therapies. PMID:35874174
Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector. PMID:35871249
Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution. PMID:35869072
TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR. PMID:35864968
Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis. PMID:35861882
Mononucleotide A-repeats may Play a Regulatory Role in Endothermic Housekeeping Genes. PMID:35860694
Development and characterization of human fetal female reproductive tract organoids to understand Müllerian duct anomalies. PMID:35858415
Marginal zone lymphoma expression of histidine-rich glycoprotein correlates with improved survival. PMID:35847718
Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity. PMID:35842425
Overexpression of LIMA1 Indicates Poor Prognosis and Promotes Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma. PMID:35837368
Decoding signal transducer and activator of transcription 1 across various cancers through data mining and integrative analysis. PMID:35836889
Cabin1 domain-containing gene picd-1 interacts with pry-1/Axin to regulate multiple processes in Caenorhabditis elegans. PMID:35835800
Detection of cell markers from single cell RNA-seq with sc2marker. PMID:35831796
The lack of association between PADI4_94 or PADI4_104 polymorphisms and RF, ACPA and anti-PAD4 in patients with rheumatoid arthritis. PMID:35831381
What are housekeeping genes? PMID:35830477
HumanMine: advanced data searching, analysis and cross-species comparison. PMID:35820040
Downregulation of PGM5 expression correlates with tumor progression and poor prognosis in human prostate cancer. PMID:35819729
EXTL3 could serve as a potential biomarker of prognosis and immunotherapy for prostate cancer and its potential mechanisms. PMID:35818069
The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells. PMID:35815953
The Potential Mechanisms of Cinobufotalin Treating Colon Adenocarcinoma by Network Pharmacology. PMID:35814224
Skeletal Muscle Myofibers Directly Contribute to LPS-Induced Systemic Inflammatory Tone. PMID:35814217
Significance of Liver Zonation in Hepatocellular Carcinoma. PMID:35813194
RELA-induced MiR-21 Exerts Oncogenic Effects on PDAC via Targeting of ARHGAP24. PMID:35812178
Advanced Glycation End Products (AGEs) and Chronic Kidney Disease: Does the Modern Diet AGE the Kidney? PMID:35807857
Prognostic Ability of Enhancer RNAs in Metastasis of Non-Small Cell Lung Cancer. PMID:35807355
The p.Pro482Ala Variant in the CNNM2 Gene Causes Severe Hypomagnesemia Amenable to Treatment with Spironolactone. PMID:35806288
Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity? PMID:35806251
Molecular Modelling Hurdle in the Next-Generation Sequencing Era. PMID:35806177
Kank1 Is Essential for Myogenic Differentiation by Regulating Actin Remodeling and Cell Proliferation in C2C12 Progenitor Cells. PMID:35805114
Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice. PMID:35800757
Suppressing the activity of CXCR4 down-regulates the expression of renal fibrosis related genes in primary glomerular cells. PMID:35800283
Shikonin Could Be Used to Treat Tubal Pregnancy via Enhancing Ferroptosis Sensitivity. PMID:35800255
Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance. PMID:35799269
Natural high-avidity T-cell receptor efficiently mediates regression of cancer/testis antigen 83 positive common solid cancers. PMID:35798537
Cytokine Receptor-Like Factor 3 (CRLF3) Contributes to Early Zebrafish Hematopoiesis. PMID:35795682
Treacle is Upregulated in Cancer and Correlates With Poor Prognosis. PMID:35794866
Ubiquitin Binding Protein 2-Like (UBAP2L): is it so NICE After All? PMID:35794863
Bladder cancer-derived exosomal KRT6B promotes invasion and metastasis by inducing EMT and regulating the immune microenvironment. PMID:35794606
A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic Targets. PMID:35791393
A systematic characterization of microglia-like cell occurrence during retinal organoid differentiation. PMID:35789843
N7-Methylguanosine Regulatory Genes Profoundly Affect the Prognosis, Progression, and Antitumor Immune Response of Hepatocellular Carcinoma. PMID:35784919
Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress. PMID:35784487
A Pan-Cancer Analysis Revealing the Dual Roles of Lysine (K)-Specific Demethylase 6B in Tumorigenesis and Immunity. PMID:35783266
UPR Responsive Genes Manf and Xbp1 in Stroke. PMID:35783104
Bridging Glycomics and Genomics: New Uses of Functional Genetics in the Study of Cellular Glycosylation. PMID:35782863
Machine learning-guided evaluation of extraction and simulation methods for cancer patient-specific metabolic models. PMID:35782748
SPTBN5, Encoding the βV-Spectrin Protein, Leads to a Syndrome of Intellectual Disability, Developmental Delay, and Seizures. PMID:35782384
Single-cell RNA sequencing data analysis suggests the cell-cell interaction patterns of the pituitary-kidney axis. PMID:35778423
High expression of N-type calcium channel indicates a favorable prognosis in gliomas. PMID:35777045
Comprehensive Urinomic Identification of Protein Alternatives to Creatinine Normalization for Diagnostic Assessment of Lupus Nephritis. PMID:35774777
Identification of Hub Genes for Early Diagnosis and Predicting Prognosis in Colon Adenocarcinoma. PMID:35774271
A Role of the TEX101 Interactome in the Common Aetiology Behind Male Subfertility and Testicular Germ Cell Tumor. PMID:35774118
Placenta-derived proteins across gestation in healthy pregnancies-a novel approach to assess placental function? PMID:35773701
N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma. PMID:35773310
Downregulation of DNMT3A Attenuates the Warburg Effect, Proliferation, and Invasion via Promoting the Inhibition of miR-603 on HK2 in Ovarian Cancer. PMID:35770296
Plasma Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) in the Acute Respiratory Distress Syndrome. PMID:35770004
The hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer. PMID:35767191
Hematopoietic Stem Cell Transplantation in ARPC1B Deficiency. PMID:35767111
SARS-CoV-2 does not replicate in HaCaT spontaneously immortalized human keratinocytes: implications for the pathogenesis of COVID-19-associated skin manifestations. PMID:35766081
Construction and validation of an m6A RNA methylation regulator prognostic model for early-stage clear cell renal cell carcinoma. PMID:35761938
Thymoquinone upregulates IL17RD in controlling the growth and metastasis of triple negative breast cancer cells in vitro. PMID:35761256
CircRNA circ_0006156 inhibits the metastasis of prostate cancer by blocking the ubiquitination of S100A9. PMID:35760899
The SKBR3 cell-membrane proteome reveals telltales of aberrant cancer cell proliferation and targets for precision medicine applications. PMID:35760832
Self-supervised learning of cell type specificity from immunohistochemical images. PMID:35758799
Roles of Cadherin2 in Thyroid Cancer. PMID:35756646
Signal Recognition Particle in Human Diseases. PMID:35754847
Prognostic Implication and Immunological Role of PSMD2 in Lung Adenocarcinoma. PMID:35754829
Characterizing the neurological phenotype of the hyperinsulinism hyperammonemia syndrome. PMID:35752848
A Novel miRNA Located in the HER2 Gene Shows an Inhibitory Effect on Wnt Signaling and Cell Cycle Progression. PMID:35747498
Shiftless, a Critical Piece of the Innate Immune Response to Viral Infection. PMID:35746809
Impact of Zinc Transport Mechanisms on Embryonic and Brain Development. PMID:35745255
Distinct Roles of NANOS1 and NANOS3 in the Cell Cycle and NANOS3-PUM1-FOXM1 Axis to Control G2/M Phase in a Human Primordial Germ Cell Model. PMID:35743036
Hepatic Macrophage Abundance and Phenotype in Aging and Liver Iron Accumulation. PMID:35742946
Bioinformatic Prioritization and Functional Annotation of GWAS-Based Candidate Genes for Primary Open-Angle Glaucoma. PMID:35741817
Identifying the Hub Genes of Glioma Peritumoral Brain Edema Using Bioinformatical Methods. PMID:35741689
Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations. PMID:35741042
Biochemical Properties and Physiological Functions of pLG72: Twenty Years of Investigations. PMID:35740983
Identifying the Potential Roles of PBX4 in Human Cancers Based on Integrative Analysis. PMID:35740947
Unique SMYD5 Structure Revealed by AlphaFold Correlates with Its Functional Divergence. PMID:35740908
Near-Infrared Photoimmunotherapy (NIR-PIT) in Urologic Cancers. PMID:35740662
Expression of GOT2 Is Epigenetically Regulated by DNA Methylation and Correlates with Immune Infiltrates in Clear-Cell Renal Cell Carcinoma. PMID:35735610
Prediction of Angiopoietin-like Protein 4-related Signaling Pathways in Cholangiocarcinoma Cells. PMID:35732325
Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation. PMID:35730929
Prognostic significance of CHAC1 expression in breast cancer. PMID:35729480
A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling. PMID:35729113
Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence. PMID:35727842
Identification of early neurodegenerative pathways in progressive multiple sclerosis. PMID:35726057
OGG1 contributes to hepatocellular carcinoma by promoting cell cycle-related protein expression and enhancing DNA oxidative damage repair in tumor cells. PMID:35723423
Novel Pharmacology Following Heteromerization of the Angiotensin II Type 2 Receptor and the Bradykinin Type 2 Receptor. PMID:35721749
CENP-A Regulation and Cancer. PMID:35721491
LIMK1: A promising prognostic and immune infiltration indicator in colorectal cancer. PMID:35720504
The Correlation Between Immune Invasion and SARS-COV-2 Entry Protein ADAM17 in Cancer Patients by Bioinformatic Analysis. PMID:35720350
Biological Characterization and Clinical Value of OAS Gene Family in Pancreatic Cancer. PMID:35719943
A Novel Secreted Protein-Related Gene Signature Predicts Overall Survival and Is Associated With Tumor Immunity in Patients With Lung Adenocarcinoma. PMID:35719915
Case Report: Balanced Reciprocal Translocation t (17; 22) (p11.2; q11.2) and 10q23.31 Microduplication in an Infertile Male Patient Suffering From Teratozoospermia. PMID:35719406
Longitudinal plasma proteomic profiling of patients with non-small cell lung cancer undergoing immune checkpoint blockade. PMID:35718373
Integrated view and comparative analysis of baseline protein expression in mouse and rat tissues. PMID:35714157
Investigating the genetic architecture of eye colour in a Canadian cohort. PMID:35712076
Differential Expression of Genes Regulating Store-operated Calcium Entry in Conjunction With Mitochondrial Dynamics as Potential Biomarkers for Cancer: A Single-Cell RNA Analysis. PMID:35711942
The Mitochondrial Protein C1QBP Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Survival, Migration and Invasion. PMID:35711850
Mass spectrometry-based draft of the mouse proteome. PMID:35710609
Autophagy Dysfunction in ALS: from Transport to Protein Degradation. PMID:35708843
The virtues and vices of protein citrullination. PMID:35706669
Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes. PMID:35705737
Sex-specific multi-level 3D genome dynamics in the mouse brain. PMID:35705546
OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy. PMID:35700042
Study Design: Human Leukocyte Antigen Class I Molecule A∗02-Chimeric Antigen Receptor Regulatory T Cells in Renal Transplantation. PMID:35694562
The Less Well-Known Little Brothers: The SLC9B/NHA Sodium Proton Exchanger Subfamily-Structure, Function, Regulation and Potential Drug-Target Approaches. PMID:35694410
Identification of Hub Genes in Colorectal Adenocarcinoma by Integrated Bioinformatics. PMID:35693937
Development and Validation of a Novel PPAR Signaling Pathway-Related Predictive Model to Predict Prognosis in Breast Cancer. PMID:35692496
Development and validation of a novel mitophagy-related gene prognostic signature for glioblastoma multiforme. PMID:35692054
TACSTD2 upregulation is an early reaction to lung infection. PMID:35688908
Assessing Protein Interactions for Clustering of Mitochondrial Urea Cycle Enzymes. PMID:35687230
Experimental Study of Potential CD8+ Trivalent Synthetic Peptides for Liver Cancer Vaccine Development Using Sprague Dawley Rat Models. PMID:35686237
Anion Transport Across Human Gallbladder Organoids and Monolayers. PMID:35685290
Exploratory Investigation of the Plasma Proteome Associated with the Endotheliopathy of Trauma. PMID:35682894
Tissue Sampling and Homogenization with NIRL Enables Spatially Resolved Cell Layer Specific Proteomic Analysis of the Murine Intestine. PMID:35682811
Could a Lower Toll-like Receptor (TLR) and NF-κB Activation Due to a Changed Charge Distribution in the Spike Protein Be the Reason for the Lower Pathogenicity of Omicron? PMID:35682644
Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors. PMID:35681645
Metabolic Profiling of Mice with Deletion of the Orphan G Protein-Coupled Receptor, GPR37L1. PMID:35681509
The identification and validation of EphA7 hypermethylation, a novel biomarker, in cervical cancer. PMID:35681118
MicroRNAs and other small RNAs in Aedes aegypti saliva and salivary glands following chikungunya virus infection. PMID:35681077
Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data. PMID:35680885
Using Next-Generation Sequencing and Bioinformatic Methods to Predict New Genes That May Be Regulated by CD47 in Oral Squamous Cell Carcinoma. PMID:35678681
Effects of Luteolin on Human Breast Cancer Using Gene Expression Array: Inferring Novel Genes. PMID:35678671
Protocol for Increasing the Sensitivity of MS-Based Protein Detection in Human Chorionic Villi. PMID:35678669
Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation. PMID:35676684
The β-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo. PMID:35674451
Patient-level proteomic network prediction by explainable artificial intelligence. PMID:35672443
Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide. PMID:35672347
Zic family member 5 promotes survival in human pancreatic cancer and cholangiocarcinoma cells. PMID:35669984
Mining database and verification of PIK3CB as a marker predicting prognosis and immune infiltration in renal clear cell carcinoma. PMID:35665729
The Ramp Atlas: facilitating tissue and cell-specific ramp sequence analyses through an intuitive web interface. PMID:35664804
NAP1L1 Functions as a Novel Prognostic Biomarker Associated With Macrophages and Promotes Tumor Progression by Influencing the Wnt/β-Catenin Pathway in Hepatocellular Carcinoma. PMID:35664324
INSC Is Down-Regulated in Colon Cancer and Correlated to Immune Infiltration. PMID:35664320
Identification of Candidate Therapeutic Genes for More Precise Treatment of Esophageal Squamous Cell Carcinoma and Adenocarcinoma. PMID:35664298
A Role for Gene-Environment Interactions in Autism Spectrum Disorder Is Supported by Variants in Genes Regulating the Effects of Exposure to Xenobiotics. PMID:35663546
The Role of Testosterone in Spermatogenesis: Lessons From Proteome Profiling of Human Spermatozoa in Testosterone Deficiency. PMID:35663320
The correlation of EZH2 expression with the progression and prognosis of hepatocellular carcinoma. PMID:35659256
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation. PMID:35657353
JUN and PDGFRA as Crucial Candidate Genes for Childhood Autism Spectrum Disorder. PMID:35655651
DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD. PMID:35655269
Development of a Phagocytosis-Dependent Gene Signature to Predict Prognosis and Response to Checkpoint Inhibition in Clear-Cell Renal Cell Carcinoma. PMID:35651604
Comprehensive analysis of the expression, prognostic significance, and function of FAM83 family members in breast cancer. PMID:35650627
Pan-Cancer Analysis, Reveals COVID-19-Related BSG as a Novel Marker for Treatment and Identification of Multiple Human Cancers. PMID:35646943
How Placenta Promotes the Successful Reproduction in High-Altitude Populations: A Transcriptome Comparison between Adaptation and Acclimatization. PMID:35642306
YOD1 serves as a potential prognostic biomarker for pancreatic cancer. PMID:35642058
OmicsNet 2.0: a web-based platform for multi-omics integration and network visual analytics. PMID:35639733
Alterations in circadian rhythms aggravate Acetaminophen-induced liver injury in mice by influencing Acetaminophen metabolization and increasing intestinal permeability. PMID:35635077
CD20+CD22+ADAM28+ B Cells in Tertiary Lymphoid Structures Promote Immunotherapy Response. PMID:35634306
Pyroptosis-related genes regulate proliferation and invasion of pancreatic cancer and serve as the prognostic signature for modeling patient survival. PMID:35633405
Endothelial EphrinB2 Regulates Sunitinib Therapy Response in Murine Glioma. PMID:35629359
Proteomics and Phosphoproteomics of Circulating Extracellular Vesicles Provide New Insights into Diabetes Pathobiology. PMID:35628588
Consensus Gene Co-Expression Network Analysis Identifies Novel Genes Associated with Severity of Fibrotic Lung Disease. PMID:35628257
Age-Related DNA Methylation in Normal Kidney Tissue Identifies Epigenetic Cancer Risk Susceptibility Loci in the ANKRD34B and ZIC1 Genes. PMID:35628134
SERTAD1 Sensitizes Breast Cancer Cells to Doxorubicin and Promotes Lysosomal Protein Biosynthesis. PMID:35625886
Antioxidant and Neuroprotective Effects of Carnosine: Therapeutic Implications in Neurodegenerative Diseases. PMID:35624713
NLRP3 licenses NLRP11 for inflammasome activation in human macrophages. PMID:35624206
Improving recombinant protein production by yeast through genome-scale modeling using proteome constraints. PMID:35624178
Investigating the Interactions of Glioma Stem Cells in the Perivascular Niche at Single-Cell Resolution using a Microfluidic Tumor Microenvironment Model. PMID:35619544
CRISPR Library Screening in Cultured Cardiomyocytes. PMID:35618895
Pan-cancer analyses reveal the genetic and pharmacogenomic landscape of transient receptor potential channels. PMID:35614079
The Overexpression of SLC25A13 Predicts Poor Prognosis and Is Correlated with Immune Cell Infiltration in Patients with Skin Cutaneous Melanoma. PMID:35607442
Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy. PMID:35606362
Semaphorin 6D as an independent predictor for better prognosis in clear cell renal cell carcinoma. PMID:35605459
hECA: The cell-centric assembly of a cell atlas. PMID:35602947
CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells. PMID:35602937
A Prognosis Marker Dynein Cytoplasmic 1 Heavy Chain 1 Correlates with EMT and Immune Signature in Liver Hepatocellular Carcinoma by Bioinformatics and Experimental Analysis. PMID:35601740
The ERG1 K+ Channel and Its Role in Neuronal Health and Disease. PMID:35600076
The product of BMP-directed differentiation protocols for human primed pluripotent stem cells is placental trophoblast and not amnion. PMID:35594861
Sperm Autoantigenic Protein 17 Predicts the Prognosis and the Immunotherapy Response of Cancers: A Pan-Cancer Analysis. PMID:35592314
Deep Visual Proteomics defines single-cell identity and heterogeneity. PMID:35590073
Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin. PMID:35587511
Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of PLOD2. PMID:35586565
Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. PMID:35584702
A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations. PMID:35584218
Innate and adaptive resistance mechanisms to arginine deprivation therapies in sarcoma and other cancers. PMID:35582579
Piezo2 is not an indispensable mechanosensor in murine cardiomyocytes. PMID:35581325
High N-Cadherin Protein Expression in Ovarian Cancer Predicts Poor Survival and Triggers Cell Invasion. PMID:35574323
Implication of a novel truncating mutation in titin as a cause of autosomal dominant left ventricular noncompaction. PMID:35572216
Identification of significant genes with a poor prognosis in skin cutaneous malignant melanoma based on a bioinformatics analysis. PMID:35571409
PDGFRα+ Interstitial Cells are Effector Cells of PACAP Signaling in Mouse and Human Colon. PMID:35569815
ImShot: An Open-Source Software for Probabilistic Identification of Proteins In Situ and Visualization of Proteomics Data. PMID:35569805
ARL2 is required for homologous recombination repair and colon cancer stem cell survival. PMID:35567502
Metastatic Transition of Pancreatic Ductal Cell Adenocarcinoma Is Accompanied by the Emergence of Pro-Invasive Cancer-Associated Fibroblasts. PMID:35565326
Updated Functional Roles of NAMPT in Carcinogenesis and Therapeutic Niches. PMID:35565188
Proteostasis Perturbations and Their Roles in Causing Sterile Inflammation and Autoinflammatory Diseases. PMID:35563729
Plasma Aldo-Keto Reductase Family 1 Member B10 as a Biomarker Performs Well in the Diagnosis of Nonalcoholic Steatohepatitis and Fibrosis. PMID:35563425
Prognostic Significance of GPR55 mRNA Expression in Colon Cancer. PMID:35562947
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance. PMID:35562425
SNAT7 regulates mTORC1 via macropinocytosis. PMID:35561222
Assessing the Potential Prognostic and Immunological Role of TK1 in Prostate Cancer. PMID:35559045
Ataxin-3, The Spinocerebellar Ataxia Type 3 Neurodegenerative Disorder Protein, Affects Mast Cell Functions. PMID:35558088
Integrative Analysis Constructs an Extracellular Matrix-Associated Gene Signature for the Prediction of Survival and Tumor Immunity in Lung Adenocarcinoma. PMID:35557945
SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility. PMID:35551471
Hierarchical network analysis of co-occurring bioentities in literature. PMID:35550589
Enhanced ASGR2 by microplastic exposure leads to resistance to therapy in gastric cancer. PMID:35547772
Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine. PMID:35546551
Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions. PMID:35538058
Correlation between myoferlin expression and lymph node metastasis in papillary thyroid carcinoma. PMID:35535365
Integrative Multi-Omics Analysis of Identified SKA3 as a Candidate Oncogene Correlates with Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma. PMID:35535142
Understudied proteins: opportunities and challenges for functional proteomics. PMID:35534633
Identification of oleoylethanolamide as an endogenous ligand for HIF-3α. PMID:35534502
Two adjacent phosphorylation sites in the C-terminus of the channel's α-subunit have opposing effects on epithelial sodium channel (ENaC) activity. PMID:35525869
Distinct responses to rare codons in select Drosophila tissues. PMID:35522036
EpCAM as a Novel Biomarker for Survivals in Prostate Cancer Patients. PMID:35517503
NIBAN1, Exploring its Roles in Cell Survival Under Stress Context. PMID:35517496
Peripheral Pathways to Neurovascular Unit Dysfunction, Cognitive Impairment, and Alzheimer's Disease. PMID:35517047
FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies. PMID:35515121
Cell-type-specific labeling and profiling of glycans in living mice. PMID:35513511
PICASSO allows ultra-multiplexed fluorescence imaging of spatially overlapping proteins without reference spectra measurements. PMID:35513404
Molecular Spatiomics by Proximity Labeling. PMID:35512328
Bioinformatic Analyzes of the Association Between Upregulated Expression of JUN Gene via APOBEC-Induced FLG Gene Mutation and Prognosis of Cervical Cancer. PMID:35510248
circ-0007707/miR-429/PDGFD Pathway Regulates the Progression of Gastric Cancer by Modulating the Immune-Gene Signature. PMID:35509844
Gaur genome reveals expansion of sperm odorant receptors in domesticated cattle. PMID:35508966
Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer. PMID:35508649
Artificial Neural Network-Based Study Predicts GS-441524 as a Potential Inhibitor of SARS-CoV-2 Activator Protein Furin: a Polypharmacology Approach. PMID:35507249
Preliminary study on the role of the C5orf46 gene in renal cancer. PMID:35504177
Genome-Wide Knockout Screen Identifies Human Sialomucin CD164 as an Essential Entry Factor for Lymphocytic Choriomeningitis Virus. PMID:35502904
Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia. PMID:35501867
Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank. PMID:35501368
The prognostic miR-532-5p-correlated ceRNA-mediated lipid droplet accumulation drives nodal metastasis of cervical cancer. PMID:35499057
Construction and Validation of Angiogenesis-Related Prognostic Risk Signature to Facilitate Survival Prediction and Biomarker Excavation of Breast Cancer Patients. PMID:35498539
The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor. PMID:35495622
Proteomics in thrombosis research. PMID:35494505
Systematic molecular analysis of the human secretome and membrane proteome in gastrointestinal adenocarcinomas. PMID:35488454
Machine learning reveals distinct gene signature profiles in lesional and nonlesional regions of inflammatory skin diseases. PMID:35486723
Dominant transcript expression profiles of human protein-coding genes interrogated with GTEx dataset. PMID:35484179
Structural insights into TRPV2 activation by small molecules. PMID:35484159
A de novo SFMBT1 pathogenic variant identified in a boy with Poland syndrome. PMID:35483874
Migraine signaling pathways: amino acid metabolites that regulate migraine and predispose migraineurs to headache. PMID:35482233
In Situ Assembly of Transmembrane Proteins from Expressed and Synthetic Components in Giant Unilamellar Vesicles. PMID:35482050
A multi-organ chip with matured tissue niches linked by vascular flow. PMID:35478225
Molecular Characterization of Membranous Nephropathy. PMID:35477557
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis. PMID:35476434
Global analysis of protein arginine methylation. PMID:35475236
SETDB1 fuels the lung cancer phenotype by modulating epigenome, 3D genome organization and chromatin mechanical properties. PMID:35474385
Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation. PMID:35472002
Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect. PMID:35471184
Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies. PMID:35468987
OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts. PMID:35462902
Effect of Short Time of SARS-CoV-2 Infection in Caco-2 Cells. PMID:35458434
Identification and Validation of miR-222-3p and miR-409-3p as Plasma Biomarkers in Gestational Diabetes Mellitus Sharing Validated Target Genes Involved in Metabolic Homeostasis. PMID:35457094
Type XX Collagen Is Elevated in Circulation of Patients with Solid Tumors. PMID:35456962
DnaJC7 in Amyotrophic Lateral Sclerosis. PMID:35456894
Network Pharmacology-Based Approach Combined with Bioinformatic Analytics to Elucidate the Potential of Curcumol against Hepatocellular Carcinoma. PMID:35456457
Novel Protein-Protein Interactions Highlighting the Crosstalk between Hypoplastic Left Heart Syndrome, Ciliopathies and Neurodevelopmental Delays. PMID:35456433
Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer. PMID:35456049
An Overview of the TRP-Oxidative Stress Axis in Metabolic Syndrome: Insights for Novel Therapeutic Approaches. PMID:35455971
HIF-1-Dependent Induction of β3 Adrenoceptor: Evidence from the Mouse Retina. PMID:35455951
A Method for Unsupervised Semi-Quantification of Inmunohistochemical Staining with Beta Divergences. PMID:35455209
Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia. PMID:35454946
Combined Alcohol Exposure and KRAS Mutation in Human Pancreatic Ductal Epithelial Cells Induces Proliferation and Alters Subtype Signatures Determined by Multi-Omics Analysis. PMID:35454872
Integrated In Silico Analyses Identify PUF60 and SF3A3 as New Spliceosome-Related Breast Cancer RNA-Binding Proteins. PMID:35453681
Development of Alzheimer's Disease Biomarkers: From CSF- to Blood-Based Biomarkers. PMID:35453600
Serotonin G Protein-Coupled Receptor-Based Biosensing Modalities in Yeast. PMID:35452231
Association between an AMH promoter polymorphism and serum AMH levels in PCOS patients. PMID:35451015
Untargeted Metabolomics of Slc13a5 Deficiency Reveal Critical Liver-Brain Axis for Lipid Homeostasis. PMID:35448538
Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity. PMID:35446253
Application of quantitative protein mass spectrometric data in the early predictive analysis of target engagement by monoclonal antibodies. PMID:35445800
Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli. PMID:35443169
Generation of human islet cell type-specific identity genesets. PMID:35440614
A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese population. PMID:35440542
CoMI: consensus mutual information for tissue-specific gene signatures. PMID:35439942
Multi-omics approaches for biomarker discovery in early ovarian cancer diagnosis. PMID:35439677
A pan-cancer analysis of the oncogenic role of secreted phosphoprotein 1 (SPP1) in human cancers. PMID:35433956
Comprehensive Analysis on Prognosis and Immune Infiltration of Lysyl Oxidase Family Members in Pancreatic Adenocarcinoma With Experimental Verification. PMID:35433829
Major Vault Protein (MVP) Associated With BRAF V600E Mutation Is an Immune Microenvironment-Related Biomarker Promoting the Progression of Papillary Thyroid Cancer via MAPK/ERK and PI3K/AKT Pathways. PMID:35433709
Analysis of L Antigen Family Member 3 as a Potential Biomarker and Therapeutic Target Associated With the Progression of Hepatocellular Carcinoma. PMID:35433409
NUSAP1 Could be a Potential Target for Preventing NAFLD Progression to Liver Cancer. PMID:35431924
Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self. PMID:35430876
The Cancer Research Database (CRDB): Integrated Platform to Gain Statistical Insight Into the Correlation Between Cancer and COVID-19. PMID:35430561
A roadmap for translational cancer glycoimmunology at single cell resolution. PMID:35428302
Modular design of synthetic receptors for programmed gene regulation in cell therapies. PMID:35427499
Systematic Characterization of the Clinical Relevance of KPNA4 in Pancreatic Ductal Adenocarcinoma. PMID:35425701
Membrane marker selection for segmenting single cell spatial proteomics data. PMID:35422106
Identification of autophagy-related biomarker and analysis of immune infiltrates in oral carcinoma. PMID:35421271
Vero cells gain renal tubule markers in low-calcium and magnesium chemically defined media. PMID:35418617
Synaptopodin stress fiber and contractomere at the epithelial junction. PMID:35416930
Bile acids and their receptors: modulators and therapeutic targets in liver inflammation. PMID:35415765
The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining stem cell osteogenesis. PMID:35415308
COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2. PMID:35414771
Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells. PMID:35414100
OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer. PMID:35413990
SwissBioPics-an interactive library of cell images for the visualization of subcellular location data. PMID:35411389
Arrow of Time, Entropy, and Protein Folding: Holistic View on Biochirality. PMID:35409047
TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression. PMID:35408935
CARD19 Interacts with Mitochondrial Contact Site and Cristae Organizing System Constituent Proteins and Regulates Cristae Morphology. PMID:35406738
Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer. PMID:35406529
Unravelling Prostate Cancer Heterogeneity Using Spatial Approaches to Lipidomics and Transcriptomics. PMID:35406474
What Is a 2021 Reference Body? PMID:35406138
Proteomic-Based Machine Learning Analysis Reveals PYGB as a Novel Immunohistochemical Biomarker to Distinguish Inverted Urothelial Papilloma From Low-Grade Papillary Urothelial Carcinoma With Inverted Growth. PMID:35402263
Efficacy and Pharmacological Mechanism of Poria cocos-Based Formulas Combined With Chemotherapy for Ovarian Cancer: A Integrated Systems Pharmacology Study. PMID:35401186
Robust Acquisition of Spatial Transcriptional Programs in Tissues With Immunofluorescence-Guided Laser Capture Microdissection. PMID:35399504
Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1. PMID:35398994
Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer. PMID:35397606
Novel integrated workflow allows production and in-depth quality assessment of multifactorial reprogrammed skeletal muscle cells from human stem cells. PMID:35396689
CRISPRs in the human genome are differentially expressed between malignant and normal adjacent to tumor tissue. PMID:35396392
Genetic evidence supports the development of SLC26A9 targeting therapies for the treatment of lung disease. PMID:35396391
Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors. PMID:35395865
Functional and structural deficiencies of Gemin5 variants associated with neurological disorders. PMID:35393353
What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy? PMID:35388168
TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis. PMID:35387985
Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? PMID:35386996
Translational Analysis of Moderate to Severe Asthma GWAS Signals Into Candidate Causal Genes and Their Functional, Tissue-Dependent and Disease-Related Associations. PMID:35386986
Physical and functional interactome atlas of human receptor tyrosine kinases. PMID:35384245
Predicted coronavirus Nsp5 protease cleavage sites in the human proteome. PMID:35379171
Structural and genome-wide analyses suggest that transposon-derived protein SETMAR alters transcription and splicing. PMID:35378129
Pannexin1 inhibits autophagy of cisplatin-resistant testicular cancer cells by mediating ATP release. PMID:35373707
OGDHL Variant rs2293239: A Potential Genetic Driver of Chinese Familial Depressive Disorder. PMID:35370858
Pyroptosis-Related Risk Signature Exhibits Distinct Prognostic, Immune, and Therapeutic Landscapes in Hepatocellular Carcinoma. PMID:35368686
Ultrastructural and proteomic profiling of mitochondria-associated endoplasmic reticulum membranes reveal aging signatures in striated muscle. PMID:35368021
AGPAT1 as a Novel Colonic Biomarker for Discriminating Between Ulcerative Colitis With and Without Primary Sclerosing Cholangitis. PMID:35363634
Study on the role of transcription factor SPI1 in the development of glioma. PMID:35361282
Identification of Pathologic and Prognostic Genes in Prostate Cancer Based on Database Mining. PMID:35360870
Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients. PMID:35360718
Impact of Vimentin on Regulation of Cell Signaling and Matrix Remodeling. PMID:35359446
Ras and Rab Interactor 3: From Cellular Mechanisms to Human Diseases. PMID:35359443
Single-Cell RNA Sequencing Revealed a 3-Gene Panel Predicted the Diagnosis and Prognosis of Thyroid Papillary Carcinoma and Associated With Tumor Immune Microenvironment. PMID:35359404
KIF26B in the Prognosis and Immune Biomarking of Various Cancers: A Pan-Cancer Study. PMID:35359341
Native Ambient Mass Spectrometry Enables Analysis of Intact Endogenous Protein Assemblies up to 145 kDa Directly from Tissue. PMID:35358391
Antigen-Specific TCR-T Cells for Acute Myeloid Leukemia: State of the Art and Challenges. PMID:35356211
Integrating protein copy numbers with interaction networks to quantify stoichiometry in clathrin-mediated endocytosis. PMID:35354856
Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids. PMID:35354790
Membrane contact probability: An essential and predictive character for the structural and functional studies of membrane proteins. PMID:35353812
The emerging role of mass spectrometry-based proteomics in drug discovery. PMID:35351998
Macrophage inhibitory cytokine-1 in cancer: Beyond the cellular phenotype. PMID:35351601
Comparing Urinary Glycoproteins among Three Urogenital Cancers and Identifying Prostate Cancer-Specific Glycoproteins. PMID:35350332
Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq. PMID:35350199
DNA methylation of Nuclear Factor of Activated T Cells 1 mediates the prospective relation between exposure to different traumatic event types and post-traumatic stress disorder. PMID:35349860
Next-generation sequencing identifies HOXA6 as a novel oncogenic gene in low grade glioma. PMID:35349479
Identification of Novel Molecular Therapeutic Targets and Their Potential Prognostic Biomarkers Based on Cytolytic Activity in Skin Cutaneous Melanoma. PMID:35345444
Age-dependent formation of TMEM106B amyloid filaments in human brains. PMID:35344985
System-level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity. PMID:35343058
Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach. PMID:35339898
In vitro culture at 39 °C during hepatic maturation of human ES cells facilitates hepatocyte-like cell functions. PMID:35338220
The landscape of receptor-mediated precision cancer combination therapy via a single-cell perspective. PMID:35338126
Discovery of Proteins Responsible for Resistance to Three Chemotherapy Drugs in Breast Cancer Cells Using Proteomics and Bioinformatics Analysis. PMID:35335125
Mining folded proteomes in the era of accurate structure prediction. PMID:35333855
Overexpressing PLOD Family Genes Predict Poor Prognosis in Pancreatic Cancer. PMID:35330878
The Prognostic Relevance of PMCA4 Expression in Melanoma: Gender Specificity and Implications for Immune Checkpoint Inhibition. PMID:35328746
GLUT3/SLC2A3 Is an Endogenous Marker of Hypoxia in Prostate Cancer Cell Lines and Patient-Derived Xenograft Tumors. PMID:35328229
Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases. PMID:35327608
A Gene Co-Expression Network-Based Drug Repositioning Approach Identifies Candidates for Treatment of Hepatocellular Carcinoma. PMID:35326724
Molecular Characterization of Portuguese Patients with Hereditary Cerebellar Ataxia. PMID:35326432
DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). PMID:35325185
Chemokine CCL17 Affects Local Immune Infiltration Characteristics and Early Prognosis Value of Lung Adenocarcinoma. PMID:35321241
Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seq. PMID:35320732
A Novel Tissue Atlas and Online Tool for the Interrogation of Small RNA Expression in Human Tissues and Biofluids. PMID:35317387
Neutrophils Require Activation to Express Functional Cell-Surface Complement Receptor Immunoglobulin. PMID:35317169
Neurotrophic receptor tyrosine kinase family members in secretory and non-secretory breast carcinomas. PMID:35316931
Self-incompatibility requires GPI anchor remodeling by the poppy PGAP1 ortholog HLD1. PMID:35316654
Differential parathyroid and kidney Ca2+-sensing receptor activation in autosomal dominant hypocalcemia 1. PMID:35313217
CRISPR-mediated knockout of VEGFR2/KDR inhibits cell growth in a squamous thyroid cancer cell line. PMID:35313079
CCDC134 as a Prognostic-Related Biomarker in Breast Cancer Correlating With Immune Infiltrates. PMID:35311121
Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium. PMID:35309931
Identification of a Methylation-Regulating Genes Prognostic Signature to Predict the Prognosis and Aid Immunotherapy of Clear Cell Renal Cell Carcinoma. PMID:35309925
Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects. PMID:35309357
A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis. PMID:35304331
Sex-specific placental gene expression signatures of small for gestational age at birth. PMID:35303517
TMEM139 prevents NSCLC metastasis by inhibiting lysosomal degradation of E-cadherin. PMID:35302694
Common coupling map advances GPCR-G protein selectivity. PMID:35302494
Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization. PMID:35300523
Discovering Novel Biomarkers Associated with the Pathogenesis of Psoriasis: Evidence from Bioinformatic Analysis. PMID:35300136
Roles of Pyroptosis-Related Gene Signature in Prediction of Endometrial Cancer Outcomes. PMID:35299842
Substrate Stiffness Determines the Establishment of Apical-Basal Polarization in Renal Epithelial Cells but Not in Tubuloid-Derived Cells. PMID:35299632
RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19. PMID:35298440
Rapid and Gentle Immunopurification of Brain Synaptic Vesicles. PMID:35296545
Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease. PMID:35294848
Altered Response Pattern following AZD5582 Treatment of SIV-Infected, ART-Suppressed Rhesus Macaque Infants. PMID:35293766
A multi-omics-based investigation of the immunological and prognostic impact of necroptosis-related genes in patients with hepatocellular carcinoma. PMID:35293027
A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer. PMID:35289315
Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy. PMID:35288587
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. PMID:35288557
Simple method for cutoff point identification in descriptive high-throughput biological studies. PMID:35287573
Auriculocondylar syndrome 2 results from the dominant-negative action of PLCB4 variants. PMID:35284927
New associations of serum β-carotene, lycopene, and zeaxanthin concentrations with NR1H3, APOB, RDH12, AND CYP genes. PMID:35282004
Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis. PMID:35281427
Energy Metabolism-Related Gene Prognostic Index Predicts Biochemical Recurrence for Patients With Prostate Cancer Undergoing Radical Prostatectomy. PMID:35280985
Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety. PMID:35280519
Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes. PMID:35279219
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy. PMID:35276062
Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells. PMID:35274124
Interplay Between the Immune and Endocrine Systems in the Lung: Implications for TB Susceptibility. PMID:35273609
Ficolin-2 Plasma Level Assesses Liver Fibrosis in Non-Alcoholic Fatty Liver Disease. PMID:35269955
PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power. PMID:35267575
PathwAX II: Network-based pathway analysis with interactive visualization of network crosstalk. PMID:35266519
Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand. PMID:35265081
CAR T Cell Therapy in Primary Brain Tumors: Current Investigations and the Future. PMID:35265074
Whole-genome sequencing reveals novel ethnicity-specific rare variants associated with Alzheimer's disease. PMID:35264725
Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates. PMID:35264686
The Role of GJD2(Cx36) in Refractive Error Development. PMID:35262731
Pan-cancer analysis of osteogenesis imperfecta causing gene SERPINF1. PMID:35261846
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination. PMID:35256818
Polo-like kinases as potential targets and PLK2 as a novel biomarker for the prognosis of human glioblastoma. PMID:35256538
Alterations in Self-Aggregating Neuropeptides in Cerebrospinal Fluid of Patients with Parkinsonian Disorders. PMID:35253777
Smoking Status and Type 2 Diabetes, and Cardiovascular Disease: A Comprehensive Analysis of Shared Genetic Etiology and Causal Relationship. PMID:35250867
A Dynamic Mass Redistribution Assay for the Human Sweet Taste Receptor Uncovers G-Protein Dependent Biased Ligands. PMID:35250580
Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions. PMID:35250281
Genetic Regulation of DNA Methylation Yields Novel Discoveries in GWAS of Colorectal Cancer. PMID:35247911
Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2. PMID:35246634
Reconstruction and analysis of a large-scale binary Ras-effector signaling network. PMID:35246154
Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids. PMID:35245440
In-Depth Profiling of O-Glycan Isomers in Human Cells Using C18 Nanoliquid Chromatography-Mass Spectrometry and Glycogenomics. PMID:35245040
A novel high throughput screen to identify candidate molecular networks that regulate spermatogenic stem cell functions†. PMID:35244684
Signal transducer and activator of transcription family is a prognostic marker associated with immune infiltration in endometrial cancer. PMID:35244291
Promoter/enhancer-based controllability of regulatory networks. PMID:35241702
Antibodies in the intracellular domain. PMID:35241366
LPAR2 correlated with different prognosis and immune cell infiltration in head and neck squamous cell carcinoma and kidney renal clear cell carcinoma. PMID:35241179
Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19. PMID:35237273
Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate. PMID:35228743
Roles of transposable elements in the regulation of mammalian transcription. PMID:35228718
Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation. PMID:35226415
Inhibition of NEK7 Suppressed Hepatocellular Carcinoma Progression by Mediating Cancer Cell Pyroptosis. PMID:35223495
Identification of CCL19 as a Novel Immune-Related Biomarker in Diabetic Nephropathy. PMID:35222545
A DNA-Methylation-Driven Genes Based Prognostic Signature Reveals Immune Microenvironment in Pancreatic Cancer. PMID:35222383
Developing Biomarkers of Mild Traumatic Brain Injury: Promise and Progress of CNS-Derived Exosomes. PMID:35222223
BEND4 as a Candidate Gene for an Infection-Induced Acute Encephalopathy Characterized by a Cyst and Calcification of the Pons and Cerebellar Atrophy. PMID:35221871
SCNN1A Overexpression Correlates with Poor Prognosis and Immune Infiltrates in Ovarian Cancer. PMID:35221714
AP-4-mediated axonal transport controls endocannabinoid production in neurons. PMID:35217685
A Novel Role of Arrhythmia-Related Gene KCNQ1 Revealed by Multi-Omic Analysis: Theragnostic Value and Potential Mechanisms in Lung Adenocarcinoma. PMID:35216393
Novel Role of Ghrelin Receptor in Gut Dysbiosis and Experimental Colitis in Aging. PMID:35216335
Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels. PMID:35216288
Investigating Glioblastoma Multiforme Sub-Proteomes: A Computational Study of CUSA Fluid Proteomic Data. PMID:35216175
Prodynorphin and Proenkephalin in Cerebrospinal Fluid of Sporadic Creutzfeldt-Jakob Disease. PMID:35216166
Interferon-β Activity Is Affected by S100B Protein. PMID:35216109
Hepatic CYP3A4 Enzyme Compensatively Maintains Endogenous Geranylgeranoic Acid Levels in MAOB-Knockout Human Hepatoma Cells. PMID:35208214
IL4Rα and IL13Rα1 Are Involved in the Development of Human Gallbladder Cancer. PMID:35207737
The Pseudokinase TRIB1 in Immune Cells and Associated Disorders. PMID:35205759
Characterization and Functional Study of FAM49B Reveals Its Effect on Cell Proliferation in HEK293T Cells. PMID:35205432
A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors. PMID:35205150
Cytoplasmic and Nuclear Functions of cIAP1. PMID:35204822
Leukemia Inhibitory Factor: An Important Cytokine in Pathologies and Cancer. PMID:35204717
Identifying Mitotic Kinesins as Potential Prognostic Biomarkers in Ovarian Cancer Using Bioinformatic Analyses. PMID:35204562
A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene? PMID:35204159
Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma. PMID:35203444
Cancer chemoprevention through Frizzled receptors and EMT. PMID:35201483
Genetic associations of protein-coding variants in human disease. PMID:35197637
The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication. PMID:35197452
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer. PMID:35197278
Systematic illumination of druggable genes in cancer genomes. PMID:35196490
Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles. PMID:35194965
[Web-based gene expression analysis-paving the way to decode healthy and diseased ocular tissue]. PMID:35194679
Evaluation of an 131I-labeled HER2-specific single domain antibody fragment for the radiopharmaceutical therapy of HER2-expressing cancers. PMID:35194100
Postnatal expression of IGF2 is the norm in amniote vertebrates. PMID:35193406
Studying membrane proteins with MicroED. PMID:35191473
A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer. PMID:35191375
The Role of Muscle Ring Finger-1 (MuRF1), MuRF2, MuRF3, and Atrogin-1 on Bone Microarchitecture In Vivo. PMID:35191000
Analysis of recent shared ancestry in a familial cohort identifies coding and noncoding autism spectrum disorder variants. PMID:35190550
Immune Characteristics of LYN in Tumor Microenvironment of Gliomas. PMID:35186945
Single-Cell Technologies to Decipher the Immune Microenvironment in Myeloid Neoplasms: Perspectives and Opportunities. PMID:35186713
Diversity and conservation of plant small secreted proteins associated with arbuscular mycorrhizal symbiosis. PMID:35184190
Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells. PMID:35183204
Transcription factor protein interactomes reveal genetic determinants in heart disease. PMID:35182466
Cellular specificity of mitochondrial and immunometabolic features in major depression. PMID:35181755
ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells. PMID:35181635
Junctional epidermolysis bullosa with extensive lung involvement in three patients with a LAMB3 Mutation. PMID:35178765
Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications. PMID:35177642
Blood-brain barrier dysfunction in L-ornithine induced acute pancreatitis in rats and the direct effect of L-ornithine on cultured brain endothelial cells. PMID:35177109
Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia. PMID:35172124
Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway. PMID:35166320
A human brain vascular atlas reveals diverse mediators of Alzheimer's risk. PMID:35165441
Inhibition of Protein N-Glycosylation Blocks SARS-CoV-2 Infection. PMID:35164559
Disruption of Kidney-Immune System Crosstalk in Sepsis with Acute Kidney Injury: Lessons Learned from Animal Models and Their Application to Human Health. PMID:35163625
Identification of a Novel Theranostic Signature of Metabolic and Immune-Inflammatory Dysregulation in Myocardial Infarction, and the Potential Therapeutic Properties of Ovatodiolide, a Diterpenoid Derivative. PMID:35163208
P-Glycoprotein and Androgen Receptor Expression Reveals Independence of Canine Prostate Cancer from Androgen Hormone Stimulation. PMID:35163087
Transcriptomic Response to Acidosis Reveals Its Contribution to Bone Metastasis in Breast Cancer Cells. PMID:35159353
Landscape of Epidermal Growth Factor Receptor Heterodimers in Brain Metastases. PMID:35158800
Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity. PMID:35158408
Selenium binding protein 1 inhibits tumor angiogenesis in colorectal cancers by blocking the Delta-like ligand 4/Notch1 signaling pathway. PMID:35158204
Adherence Enables Neisseria gonorrhoeae to Overcome Zinc Limitation Imposed by Nutritional Immunity Proteins. PMID:35156850
Comprehensive and Integrative Analysis of Two Novel SARS-CoV-2 Entry Associated Proteases CTSB and CTSL in Healthy Individuals and Cancer Patients. PMID:35155389
Whole-Exome Sequencing Implicates Neuronal Calcium Channel with Familial Atrial Fibrillation. PMID:35154276
Identification of a Novel Nomogram to Predict Progression Based on the Circadian Clock and Insights Into the Tumor Immune Microenvironment in Prostate Cancer. PMID:35154101
Insights Into the Emergence of Paroxysmal Nocturnal Hemoglobinuria. PMID:35154088
Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer. PMID:35153749
ERCC6L is a biomarker and therapeutic target for non-small cell lung adenocarcinoma. PMID:35150321
Machine learning prediction and tau-based screening identifies potential Alzheimer's disease genes relevant to immunity. PMID:35149761
The spatial transcriptomic landscape of the healing mouse intestine following damage. PMID:35149721
A mammalian methylation array for profiling methylation levels at conserved sequences. PMID:35145108
High male specific contribution of the X-chromosome to individual global recombination rate in dairy cattle. PMID:35144552
RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells. PMID:35143476
14-3-3 Proteins are Potential Regulators of Liquid-Liquid Phase Separation. PMID:35142991
Glioma targeted therapy: insight into future of molecular approaches. PMID:35135556
Analysis of SARS-CoV-2 synonymous codon usage evolution throughout the COVID-19 pandemic. PMID:35134624
Multimerin-1 and cancer: a review. PMID:35132992
Early immune responses have long-term associations with clinical, virologic, and immunologic outcomes in patients with COVID-19. PMID:35132407
KLRK1 as a prognostic biomarker for lung adenocarcinoma cancer. PMID:35132098
Combined assessment of MHC binding and antigen abundance improves T cell epitope predictions. PMID:35128348
Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer. PMID:35127694
Enhancer RNA LINC00242-Induced Expression of PHF10 Drives a Better Prognosis in Pancreatic Adenocarcinoma. PMID:35127503
Shared Genetic Architecture and Causal Relationship Between Asthma and Cardiovascular Diseases: A Large-Scale Cross-Trait Analysis. PMID:35126453
The Expression of Inflammasomes NLRP1 and NLRP3, Toll-Like Receptors, and Vitamin D Receptor in Synovial Fibroblasts From Patients With Different Types of Knee Arthritis. PMID:35126351
Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment. PMID:35122074
The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets. PMID:35121907
RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4+ T-cell-dependent antitumor immunity. PMID:35121884
Leveraging interacting signaling pathways to robustly improve the quality and yield of human pluripotent stem cell-derived hepatoblasts and hepatocytes. PMID:35120625
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. PMID:35120601
HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease. PMID:35120281
Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis. PMID:35119778
Expression Profiles of Estrogen-Regulated MicroRNAs in Cancer Cells. PMID:35119673
BACE1: More than just a β-secretase. PMID:35119166
Pyruvate kinase M2 is a marker of poor prognosis in lung adenocarcinoma but not lung squamous cell carcinoma. PMID:35117696
Multi-omics analysis reveals the BRCA1 mutation and mismatch repair gene signatures associated with survival, protein expression, and copy number alterations in prostate cancer. PMID:35116870
Sideroflexin1 as a novel tumor marker independently predicts survival in lung adenocarcinoma. PMID:35116859
Bioinformatic analysis of PLOD family member expression and prognostic value in non-small cell lung cancer. PMID:35116582
The role of TRIM51 as a multipurpose biomarker in melanoma. PMID:35116291
GOLM1 as a Potential Therapeutic Target Modulates B7-H3 Secretion to Drive Ovarian Cancer Metastasis. PMID:35116068
Exploring the Multi-Tissue Crosstalk Relevant to Insulin Resistance Through Network-Based Analysis. PMID:35116003
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines. PMID:35115730
AKR1C1/2 inhibition by MPA sensitizes platinum resistant ovarian cancer towards carboplatin. PMID:35115586
Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis. PMID:35113855
Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates. PMID:35110592
Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation. PMID:35110545
Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy. PMID:35107989
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study. PMID:35106505
Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids. PMID:35106453
The Impact of Nonalcoholic Fatty Liver Disease on the Outcomes of Coronavirus Disease 2019 Infection. PMID:35106147
Galectins as potential therapeutic targets in STIs in the female genital tract. PMID:35105978
ER-phagy requires the assembly of actin at sites of contact between the cortical ER and endocytic pits. PMID:35101986
Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer. PMID:35101137
MethReg: estimating the regulatory potential of DNA methylation in gene transcription. PMID:35100398
ZNF146/OZF and ZNF507 target LINE-1 sequences. PMID:35100360
Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types. PMID:35100265
Novel Classes and Evolutionary Turnover of Histone H2B Variants in the Mammalian Germline. PMID:35099534
Potential Clinical Value of Biomarker-Guided Emergency Triage for Thoracic Aortic Dissection. PMID:35096998
TMC5 is Highly Expressed in Human Cancers and Corelates to Prognosis and Immune Cell Infiltration: A Comprehensive Bioinformatics Analysis. PMID:35096973
The FUT2 Variant c.461G>A (p.Trp154*) Is Associated With Differentially Expressed Genes and Nasopharyngeal Microbiota Shifts in Patients With Otitis Media. PMID:35096646
Prognostic Signatures and Therapeutic Value Based on the Notch Pathway in Renal Clear Cell Carcinoma. PMID:35096263
Construction and Validation of a Newly Prognostic Signature for CRISPR-Cas9-Based Cancer Dependency Map Genes in Breast Cancer. PMID:35096059
Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury. PMID:35091838
Cortical and Subcortical Dysmetabolism Are Dynamic Markers of Clinical Disability and Course in Anti-LGI1 Encephalitis. PMID:35091466
Chronic exposure to delta-9-tetrahydrocannabinol impacts testicular volume and male reproductive health in rhesus macaques. PMID:35090702
CANT1 serves as a potential prognostic factor for lung adenocarcinoma and promotes cell proliferation and invasion in vitro. PMID:35090419
Faster skin wound healing predicts survival after myocardial infarction. PMID:35089808
Integrin-linked kinase (ILK): the known vs. the unknown and perspectives. PMID:35089438
AXIN-AMPK signaling: Implications for healthy aging. PMID:35087668
A novel variant in SMG9 causes intellectual disability, confirming a role for nonsense-mediated decay components in neurocognitive development. PMID:35087184
Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing. PMID:35085231
The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells. PMID:35084980
Emerging Progress in Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum: Challenges and Opportunities. PMID:35083256
Expressing the Human Cholesteryl Ester Transfer Protein Minigene Improves Diet-Induced Fatty Liver and Insulin Resistance in Female Mice. PMID:35082691
The Age-Specific Features and Clinical Significance of NRF2 and MAPK10 Expression in HCC Patients. PMID:35082522
Alternative splicing regulation of membrane trafficking genes during myogenesis. PMID:35082143
A genome-wide association study of serum proteins reveals shared loci with common diseases. PMID:35078996
Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells. PMID:35078919
Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource. PMID:35078504
High complement protein C1q levels in pulmonary fibrosis and non-small cell lung cancer associated with poor prognosis. PMID:35078421
Serotonin: an overlooked regulator of endocytosis and endosomal sorting? PMID:35076063
The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation. PMID:35076027
Genome-wide annotation of protein-coding genes in pig. PMID:35073880
Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM. PMID:35073561
Identification of a novel pyroptosis-related gene signature correlated with the prognosis of diffuse glioma patients. PMID:35071460
High expression of Ran binding protein 1 predicts poor outcomes in hepatocellular carcinoma patients: a Cancer Genome Atlas database analysis. PMID:35070423
Mechanism of SARS-CoV-2 Invasion into the Liver and Hepatic Injury in Patients with COVID-19. PMID:35070210
Comprehensive Pan-Cancer Genomic Analysis Reveals PHF19 as a Carcinogenic Indicator Related to Immune Infiltration and Prognosis of Hepatocellular Carcinoma. PMID:35069553
High expression of PDZ-binding kinase is correlated with poor prognosis and immune infiltrates in hepatocellular carcinoma. PMID:35065633
Impact of ADAR-induced editing of minor viral RNA populations on replication and transmission of SARS-CoV-2. PMID:35064076
Selective Deletion of the Mechanistic Target of Rapamycin From the Renal Collecting Duct Principal Cell in Mice Down-Regulates the Epithelial Sodium Channel. PMID:35058797
Identification of an ACK1/TNK2-based prognostic signature for colon cancer to predict survival and inflammatory landscapes. PMID:35057760
The Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature. PMID:35055804
Clin.iobio: A Collaborative Diagnostic Workflow to Enable Team-Based Precision Genomics. PMID:35055388
Identifying Candidate Protein Markers of Acute Kidney Injury in Acute Decompensated Heart Failure. PMID:35055195
Syndecan-4 Is a Key Facilitator of the SARS-CoV-2 Delta Variant's Superior Transmission. PMID:35054983
Bisphenol S Impairs Invasion and Proliferation of Extravillous Trophoblasts Cells by Interfering with Epidermal Growth Factor Receptor Signaling. PMID:35054855
Telomere and Telomerase-Associated Proteins in Endometrial Carcinogenesis and Cancer-Associated Survival. PMID:35054812
CircFISH: A Novel Method for the Simultaneous Imaging of Linear and Circular RNAs. PMID:35053590
Smell Detection Agent Optimisation Framework and Systems Biology Approach to Detect Dys-Regulated Subnetwork in Cancer Data. PMID:35053185
LRP6 Receptor Plays Essential Functions in Development and Human Diseases. PMID:35052459
Preclinical Research in McArdle Disease: A Review of Research Models and Therapeutic Strategies. PMID:35052414
Circulatory MicroRNAs in Plasma and Atrial Fibrillation in the General Population: The Rotterdam Study. PMID:35052352
SATB2 and MDM2 Immunoexpression and Diagnostic Role in Primary Osteosarcomas of the Jaw. PMID:35049602
A whole-exome case-control association study to characterize the contribution of rare coding variation to pancreatic cancer risk. PMID:35047863
Multi-Omics Analysis for Transcriptional Regulation of Immune-Related Targets Using Epigenetic Data: A New Research Direction. PMID:35046932
Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model. PMID:35046474
The Mlc1 Promoter Directs Müller Cell-specific Gene Expression in the Retina. PMID:35040915
Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer. PMID:35040374
Harnessing big data to characterize immune-related adverse events. PMID:35039679
Stabilization and structure determination of integral membrane proteins by termini restraining. PMID:35039670
Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity. PMID:35036073
Loss of full-length pumilio 1 abrogates miRNA-221-induced gene p27 silencing-mediated cell proliferation in the heart. PMID:35036057
Core promoter mutation contributes to abnormal gene expression in bladder cancer. PMID:35033028
Renin-angiotensin system blockade on angiotensin-converting enzyme 2 and TMPRSS2 in human type II pneumocytes. PMID:35032553
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids. PMID:35032430
Calcium selective channel TRPV6: Structure, function, and implications in health and disease. PMID:35031425
Regenerating islet-derived protein 3-α is a prognostic biomarker for gastrointestinal chronic graft-versus-host disease. PMID:35030629
Computer-aided design of reversible hybridization chain reaction (CAD-HCR) enables multiplexed single-cell spatial proteomics imaging. PMID:35030012
Characterization and use of the ECV304 autoantigenic citrullinome to understand anti-citrullinated protein/peptide autoantibodies in rheumatoid arthritis. PMID:35027076
IBEX: an iterative immunolabeling and chemical bleaching method for high-content imaging of diverse tissues. PMID:35022622
The amniotic fluid proteome changes with gestational age in normal pregnancy: a cross-sectional study. PMID:35022423
Connexin 43 confers chemoresistance through activating PI3K. PMID:35022385
Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene. PMID:35015732
Synthesis of broad-specificity activity-based probes for exo-β-mannosidases. PMID:35015006
Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. PMID:35013352
A de novo paradigm for male infertility. PMID:35013161
Endosomal Recycling Defects and Neurodevelopmental Disorders. PMID:35011709
The Sulfotransferase SULT1C2 Is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and Is Associated with Patient Outcome in Lung Adenocarcinoma. PMID:35010676
AGC1 Deficiency: Pathology and Molecular and Cellular Mechanisms of the Disease. PMID:35008954
Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma. PMID:35008509
Anticancer Activities of 9-chloro-6-(piperazin-1-yl)-11H-indeno[1,2-c] quinolin-11-one (SJ10) in Glioblastoma Multiforme (GBM) Chemoradioresistant Cell Cycle-Related Oncogenic Signatures. PMID:35008426
Targeting Post-Translational Regulation of p53 in Colorectal Cancer by Exploiting Vulnerabilities in the p53-MDM2 Axis. PMID:35008383
A Gene Signature Derived from the Loss of CDKN1A (p21) Is Associated with CMS4 Colorectal Cancer. PMID:35008299
HPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes. PMID:35008200
Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single-cell analysis. PMID:35007307
Integrated bioinformatics and experiments reveal the roles and driving forces for HSF1 in colorectal cancer. PMID:35006040
LCK and CD3E Orchestrate the Tumor Microenvironment and Promote Immunotherapy Response and Survival of Muscle-Invasive Bladder Cancer Patients. PMID:35004669
CD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a pigmented melanoma model. PMID:35003897
Cytochrome b561 Serves as a Potential Prognostic Biomarker and Target for Breast Cancer. PMID:35002301
Circulating Tumor Cell Transcriptomics as Biopsy Surrogates in Metastatic Breast Cancer. PMID:35000083
Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells. PMID:34999972
Batokines: Mediators of Inter-Tissue Communication (a Mini-Review). PMID:34997461
The proprotein convertase furin in cancer: more than an oncogene. PMID:34997216
Identification of Key Transcription Factors and Immune Infiltration Patterns Associated With Breast Cancer Prognosis Using WGCNA and Cox Regression Analysis. PMID:34993131
Identification of ubiquitinated substrate proteins and their gene expression patterns in lung adenocarcinoma. PMID:34988201
High Expression of Ubiquitin-Specific Protease 39 and Its Roles in Prognosis in Patients with Hepatocellular Carcinoma. PMID:34987596
RNA profiles reveal signatures of future health and disease in pregnancy. PMID:34987224
LRG1 as a novel therapeutic target in eye disease. PMID:34987199
TF-Marker: a comprehensive manually curated database for transcription factors and related markers in specific cell and tissue types in human. PMID:34986601
A test of the pioneer factor hypothesis using ectopic liver gene activation. PMID:34984978
Convergent evolution of venom gland transcriptomes across Metazoa. PMID:34983844
Regulation of fatty acid desaturase- and immunity gene-expression by mbk-1/DYRK1A in Caenorhabditis elegans. PMID:34983389
Chlamydomonas ARMC2/PF27 is an obligate cargo adapter for intraflagellar transport of radial spokes. PMID:34982025
Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation. PMID:34981765
The diagnostic and prognostic significance of small nuclear ribonucleoprotein Sm D1 aberrantly high expression in hepatocellular carcinoma. PMID:34976182
STXBP6 and B3GNT6 Genes are Associated With Selective IgA Deficiency. PMID:34976003
The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology. PMID:34975914
Breast Cancer Risk with Progestin Subdermal Implants: A Challenge in Patients Counseling. PMID:34975755
An Robust Rank Aggregation and Least Absolute Shrinkage and Selection Operator Analysis of Novel Gene Signatures in Dilated Cardiomyopathy. PMID:34970603
Alpha-2-Macroglobulin in Inflammation, Immunity and Infections. PMID:34970276
β3-Adrenoceptor, a novel player in the round-trip from neonatal diseases to cancer: Suggestive clues from embryo. PMID:34967048
Urine proteomics identifies biomarkers for diabetic kidney disease at different stages. PMID:34963468
Inositol Phosphates and Retroviral Assembly: A Cellular Perspective. PMID:34960784
Dynamic, but Not Necessarily Disordered, Human-Virus Interactions Mediated through SLiMs in Viral Proteins. PMID:34960638
Comprehensive Analysis of Myoferlin in Human Pancreatic Cancer via Bioinformatics. PMID:34957301
Cholesterol metabolism: from lipidomics to immunology. PMID:34953867
AHDC1 missense mutations in Xia-Gibbs syndrome. PMID:34950897
HPV16-LINC00393 Integration Alters Local 3D Genome Architecture in Cervical Cancer Cells. PMID:34950609
Identification and Clinical Validation of Key Extracellular Proteins as the Potential Biomarkers in Relapsing-Remitting Multiple Sclerosis. PMID:34950135
Multi-Omics Reveal the Immunological Role and the Theragnostic Value of miR-216a/GDF15 Axis in Human Colon Adenocarcinoma. PMID:34948431
Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer's Disease. PMID:34948414
IRAG2 Interacts with IP3-Receptor Types 1, 2, and 3 and Regulates Intracellular Ca2+ in Murine Pancreatic Acinar Cells. PMID:34948204
NAPRT Expression Regulation Mechanisms: Novel Functions Predicted by a Bioinformatics Approach. PMID:34946971
MiRNA-Regulated Pathways for Hypertrophic Cardiomyopathy: Network-Based Approach to Insight into Pathogenesis. PMID:34946964
SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase. PMID:34944965
Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism. PMID:34944728
SYNE1 Exonic Variant rs9479297 Contributes to Concurrent Hepatocellular and Transitional Cell Carcinoma Double Primary Cancer. PMID:34944636
Reduction of Rapid Proliferating Tumour Cell Lines by Inhibition of the Specific Glycine Transporter GLYT1. PMID:34944586
Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues. PMID:34944551
The Role of Estrogens and Vitamin D in Cardiomyocyte Protection: A Female Perspective. PMID:34944459
Mouse Organ-Specific Proteins and Functions. PMID:34943957
An Insight into GPCR and G-Proteins as Cancer Drivers. PMID:34943797
Large-Scale Tissue Microarray Evaluation Corroborates High Specificity of High-Level Arginase-1 Immunostaining for Hepatocellular Carcinoma. PMID:34943588
Ephrin Receptors (Ephs) Expression in Thymic Epithelial Tumors: Prognostic Implications and Future Therapeutic Approaches. PMID:34943502
Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer. PMID:34943457
mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells. PMID:34943047
Early Pregnancy Exposure to Ambient Air Pollution among Late-Onset Preeclamptic Cases Is Associated with Placental DNA Hypomethylation of Specific Genes and Slower Placental Maturation. PMID:34941772
Evaluation of Placental Alkaline Phosphatase Expression as A Potential Target of Solid Tumors Immunotherapy by Using Gene and Protein Expression Repositories. PMID:34939766
Identification of α1,2-fucosylated signaling and adhesion molecules in head and neck squamous cell carcinoma. PMID:34939118
A graphical representation of glycan heterogeneity. PMID:34939082
TNFRSF11B Suppresses Memory CD4+ T Cell Infiltration in the Colon Cancer Microenvironment: A Multiomics Integrative Analysis. PMID:34938284
Rhesus Macaque CODEX Multiplexed Immunohistochemistry Panel for Studying Immune Responses During Ebola Infection. PMID:34938283
Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites. PMID:34934117
Toxoplasma-proximal and distal control by GBPs in human macrophages. PMID:34931666
Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells. PMID:34930929
LDexpress: an online tool for integrating population-specific linkage disequilibrium patterns with tissue-specific expression data. PMID:34930111
Ischemic Heart Disease Selectively Modifies the Right Atrial Appendage Transcriptome. PMID:34926599
Integrative Analysis of MALT1 as a Potential Therapeutic Target for Prostate Cancer and its Immunological Role in Pan-Cancer. PMID:34926571
Prognostic Implications and Immune Infiltration Analysis of ALDOA in Lung Adenocarcinoma. PMID:34925439
EASINESS: E. coli Assisted Speedy affINity-maturation Evolution SyStem. PMID:34925322
Subcellular Transcriptomics and Proteomics: A Comparative Methods Review. PMID:34922010
KRAS mutation-independent downregulation of MAPK/PI3K signaling in colorectal cancer. PMID:34919787
TBX1 functions as a putative oncogene of breast cancer through promoting cell cycle progression. PMID:34919666
NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis. PMID:34919052
Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume. PMID:34916497
Identification of Key Deregulated RNA-Binding Proteins in Pancreatic Cancer by Meta-Analysis and Prediction of Their Role as Modulators of Oncogenesis. PMID:34912796
Epigenetic loss of heterogeneity from low to high grade localized prostate tumours. PMID:34911933
Misexpression of genes lacking CpG islands drives degenerative changes during aging. PMID:34910517
Potential Novel Modules and Hub Genes as Prognostic Candidates of Thyroid Cancer by Weighted Gene Co-Expression Network Analysis. PMID:34908870
Integrative analysis reveals methylenetetrahydrofolate dehydrogenase 1-like as an independent shared diagnostic and prognostic biomarker in five different human cancers. PMID:34908119
Transcriptomic adaptation during skeletal muscle habituation to eccentric or concentric exercise training. PMID:34907264
IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies. PMID:34906138
Plasma-Derived Extracellular Vesicles Reveal Galectin-3 Binding Protein as Potential Biomarker for Early Detection of Glioma. PMID:34900729
How Times Have Changed! A Cornucopia of Antigens for Membranous Nephropathy. PMID:34899763
Pharmacological Activation of cGAS for Cancer Immunotherapy. PMID:34899704
Pan-Cancer Analysis Reveals the Signature of TMC Family of Genes as a Promising Biomarker for Prognosis and Immunotherapeutic Response. PMID:34899684
Monitoring one-carbon metabolism by mass spectrometry to assess liver function and disease. PMID:34897580
Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation. PMID:34896640
GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus. PMID:34893534
A poly(ethylene glycol) three-dimensional bone marrow hydrogel. PMID:34890973
MLL4 mediates differentiation and tumor suppression through ferroptosis. PMID:34890228
Carboxypeptidase A1 (CPA1) Immunohistochemistry Is Highly Sensitive and Specific for Acinar Cell Carcinoma (ACC) of the Pancreas. PMID:34889867
FAPI-04 Uptake in Healthy Tissues of Cancer Patients in 68Ga-FAPI-04 PET/CT Imaging. PMID:34887714
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus. PMID:34887389
Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity. PMID:34885241
The Role of Arginine Metabolism in Oral Tongue Squamous Cell Carcinoma. PMID:34885177
Renal Safety Profile of EGFR Targeted Therapies: A Study from VigiBase® the WHO Global Database of Individual Case Safety Reports. PMID:34885014
The Extracellular Matrix Environment of Clear Cell Renal Cell Carcinoma Determines Cancer Associated Fibroblast Growth. PMID:34884982
Differential Actions of Muscarinic Receptor Subtypes in Gastric, Pancreatic, and Colon Cancer. PMID:34884958
Fibroblast Activation Protein Targeted Photodynamic Therapy Selectively Kills Activated Skin Fibroblasts from Systemic Sclerosis Patients and Prevents Tissue Contraction. PMID:34884484
Variable expression of eighteen common housekeeping genes in human non-cancerous kidney biopsies. PMID:34882702
Hypomethylation-driven AKT Serine/Threonine Kinase 3 promotes testicular germ cell tumors proliferation and negatively correlates to immune infiltration. PMID:34882061
A convenient test system for the identification of CYP4V2 inhibitors. PMID:34880593
A proteomics study identifying interactors of the FSHD2 gene product SMCHD1 reveals RUVBL1-dependent DUX4 repression. PMID:34880314
Epigenetic Silencing of 15-Hydroxyprostaglandin Dehydrogenase by Histone Methyltransferase EHMT2/G9a in Cholangiocarcinoma. PMID:34880125
Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19. PMID:34878969
Characterization of the GATA Transcription Factor Family and Exploration of Their Relevance to Immune Infiltration and Tumor Microenvironment in Pancreatic Cancer. PMID:34876843
High expression of eIF4E is associated with tumor macrophage infiltration and leads to poor prognosis in breast cancer. PMID:34876062
Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis. PMID:34874915
Altered protein secretion in Batten disease. PMID:34870700
With No Lysine Kinase 1 Promotes Metabolic Derangements and RV Dysfunction in Pulmonary Arterial Hypertension. PMID:34869947
Comprehensive Analysis and Identification of Prognostic Biomarkers and Therapeutic Targets Among FAM83 Family Members for Gastric Cancer. PMID:34869310
RNA-Binding Protein Expression Alters Upon Differentiation of Human B Cells and T Cells. PMID:34867946
Multi-modal Profiling of the Extracellular Matrix of Human Fallopian Tubes and Serous Tubal Intraepithelial Carcinomas. PMID:34866441
Dopamine and fear memory formation in the human amygdala. PMID:34862441
Phenome risk classification enables phenotypic imputation and gene discovery in developmental stuttering. PMID:34861174
Facioscapulohumeral dystrophy weakened sarcomeric contractility is mimicked in induced pluripotent stem cells-derived innervated muscle fibres. PMID:34859613
Large-scale integration of the plasma proteome with genetics and disease. PMID:34857953
ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function. PMID:34857875
Cell type-specific analysis by single-cell profiling identifies a stable mammalian tRNA-mRNA interface and increased translation efficiency in neurons. PMID:34857654
Periodontitis Risk Variants at SIGLEC5 Impair ERG and MAFB Binding. PMID:34852650
Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast. PMID:34849907
A cross-species approach for the identification of Drosophila male sterility genes. PMID:34849808
Expression of human HIPKs in Drosophila demonstrates their shared and unique functions in a developmental model. PMID:34849772
Biallelic inheritance in a single Pakistani family with intellectual disability implicates new candidate gene RDH14. PMID:34848785
LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry in trans. PMID:34845449
Serine catabolism generates liver NADPH and supports hepatic lipogenesis. PMID:34845393
Super-resolved spatial transcriptomics by deep data fusion. PMID:34845373
Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation. PMID:34845248
Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms. PMID:34844191
Proteome of the Luminal Surface of the Blood-Brain Barrier. PMID:34842825
Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure. PMID:34842295
Comprehensive gene cluster analysis of head and neck squamous cell carcinoma TCGA RNA-seq data defines B cell immunity-related genes as a robust survival predictor. PMID:34841601
SLC13A4 Might Serve as a Prognostic Biomarker and be Correlated with Immune Infiltration into Head and Neck Squamous Cell Carcinoma. PMID:34840533
Prognostic Value Estimation of BRIP1 in Breast Cancer by Exploiting Transcriptomics Data Through Bioinformatics Approaches. PMID:34840500
Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients. PMID:34839279
COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations. PMID:34837225
Identifying the Predictive Role of Oxidative Stress Genes in the Prognosis of Glioma Patients. PMID:34836934
Protein Aggregation of NPAS3, Implicated in Mental Illness, Is Not Limited to the V304I Mutation. PMID:34834422
Revisiting the Role of GSK3, A Modulator of Innate Immunity, in Idiopathic Inclusion Body Myositis. PMID:34831477
Identification of Cellular Factors Required for SARS-CoV-2 Replication. PMID:34831382
Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer's Disease. PMID:34831245
Diagnostic and Prognostic Implications of Caspase-1 and PD-L1 Co-Expression Patterns in Myelodysplastic Syndromes. PMID:34830867
The Protein Landscape of Mucinous Ovarian Cancer: Towards a Theranostic. PMID:34830751
Chemical Exposures Affect Innate Immune Response to SARS-CoV-2. PMID:34830356
Biochemical Characterisation of Human Transglutaminase 4. PMID:34830327
Molecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development. PMID:34830058
Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma. PMID:34829830
Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies. PMID:34829671
Integration and Visualization of Regulatory Elements and Variations of the EPAS1 Gene in Human. PMID:34828399
Gender-Specific Metabolomics Approach to Kidney Cancer. PMID:34822425
Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer. PMID:34821068
Proteomic profiling identifies signatures associated with progression of precancerous gastric lesions and risk of early gastric cancer. PMID:34818622
Feedback Loop Regulation between Pim Kinases and Tax Keeps Human T-Cell Leukemia Virus Type 1 Viral Replication in Check. PMID:34818069
Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. PMID:34817906
ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis. PMID:34816763
Lymphocyte cytosolic protein 2 is a novel prognostic marker in lung adenocarcinoma. PMID:34816740
Lysosomal dysfunction impairs mitochondrial quality control and is associated with neurodegeneration in TBCK encephaloneuronopathy. PMID:34816123
A proximity proteomics screen in three-dimensional spheroid cultures identifies novel regulators of lumen formation. PMID:34815476
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging. PMID:34811556
Exploring the signaling space of a GPCR using bivalent ligands with a rigid oligoproline backbone. PMID:34810259
Delayed DNA replication in haploid human embryonic stem cells. PMID:34810218
Distinct associations of NEDD4L expression with genetic abnormalities and prognosis in acute myeloid leukemia. PMID:34809620
Whole-exome analysis of adolescents with low VWF and heavy menstrual bleeding identifies novel genetic associations. PMID:34807970
Elucidating the Activation Mechanism of AMPK by Direct Pan-Activator PF-739. PMID:34805275
Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer. PMID:34804118
Comprehensive Analysis of m6A RNA Methylation Regulators and the Immune Microenvironment to Aid Immunotherapy in Pancreatic Cancer. PMID:34804059
Construction of circRNA-miRNA-mRNA network and identification of novel potential biomarkers for non-small cell lung cancer. PMID:34801043
PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer. PMID:34800542
Methionine synthase supports tumour tetrahydrofolate pools. PMID:34799699
A glucagon analogue decreases body weight in mice via signalling in the liver. PMID:34799628
Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. PMID:34798047
Phosphatidylserine receptors enhance SARS-CoV-2 infection. PMID:34797899
Glia Maturation Factor Beta as a Novel Biomarker and Therapeutic Target for Hepatocellular Carcinoma. PMID:34796110
Induction of Anti-Aquaporin 5 Autoantibody Production by Immunization with a Peptide Derived from the Aquaporin of Prevotella melaninogenica Leads to Reduced Salivary Flow in Mice. PMID:34796038
Homozygous duplication identified by whole genome sequencing causes LRBA deficiency. PMID:34795304
A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients. PMID:34794066
Single-Cell, Single-Nucleus, and Spatial RNA Sequencing of the Human Liver Identifies Cholangiocyte and Mesenchymal Heterogeneity. PMID:34792289
A Cholesterol Homeostasis-Related Gene Signature Predicts Prognosis of Endometrial Cancer and Correlates With Immune Infiltration. PMID:34790227
Integrated Analysis of Expression and Prognostic Values of Acyl-CoA Dehydrogenase short-chain in Colorectal Cancer. PMID:34790035
C/EBPZ modulates the differentiation and proliferation of preadipocytes. PMID:34789850
Multidimensional Analysis of the Role of Charged Multivesicular Body Protein 7 in Pan-Cancer. PMID:34785938
ATRX proximal protein associations boast roles beyond histone deposition. PMID:34780483
Controversies surrounding peripheral cannabinoid receptor 1 in fatty liver disease. PMID:34779413
A large-scale transcriptome-wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine-mapping. PMID:34779012
Radioresistance of Human Cancers: Clinical Implications of Genetic Expression Signatures. PMID:34778082
Sodium-Glucose Co-Transporter 2 Inhibitors May Change the Development of Urinary Tract and Hematological Malignancies as Compared With Dipeptidyl Peptidase-4 Inhibitors: Data of the Post-Hoc Analysis of a Nationwide Study. PMID:34778040
Knockdown of Oligosaccharyltransferase Subunit Ribophorin 1 Induces Endoplasmic-Reticulum-Stress-Dependent Cell Apoptosis in Breast Cancer. PMID:34778038
Suprabasin: Role in human cancers and other diseases. PMID:34775572
GCC2 as a New Early Diagnostic Biomarker for Non-Small Cell Lung Cancer. PMID:34771645
Take Me Home, Protein Roads: Structural Insights into Signal Peptide Interactions during ER Translocation. PMID:34769302
Growth of Biological Complexity from Prokaryotes to Hominids Reflected in the Human Genome. PMID:34769071
Infection of Brain Pericytes Underlying Neuropathology of COVID-19 Patients. PMID:34769052
Revealing the Molecular Mechanisms of Alzheimer's Disease Based on Network Analysis. PMID:34768988
An RNA-Seq-Based Framework for Characterizing Canine Prostate Cancer and Prioritizing Clinically Relevant Biomarker Candidate Genes. PMID:34768937
Prognostic biomarkers for predicting papillary thyroid carcinoma patients at high risk using nine genes of apoptotic pathway. PMID:34767591
Severe types of fetopathy are associated with changes in the serological proteome of diabetic mothers. PMID:34766598
Expression of macrophage migration inhibitory factor and its receptor CD74 in systemic sclerosis. PMID:34764810
Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes. PMID:34762911
1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development. PMID:34762852
EZHIP: a new piece of the puzzle towards understanding pediatric posterior fossa ependymoma. PMID:34762160
Model-based assessment of mammalian cell metabolic functionalities using omics data. PMID:34761247
Na+/H+-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer. PMID:34759967
Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis. PMID:34758873
RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. PMID:34758294
AdipoAtlas: A reference lipidome for human white adipose tissue. PMID:34755127
Evolutionary selection of alleles in the melanophilin gene that impacts on prostate organ function and cancer risk. PMID:34754452
Aguascalientes: one of the hottest chronic kidney disease (CKD) hotspots in Mexico and a CKD of unknown aetiology mystery to be solved. PMID:34754425
Cancer drivers and clonal dynamics in acute lymphoblastic leukaemia subtypes. PMID:34753926
BH3-mimetics: recent developments in cancer therapy. PMID:34753495
Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle. PMID:34752468
Anatomical structures, cell types and biomarkers of the Human Reference Atlas. PMID:34750582
The human telomeric proteome during telomere replication. PMID:34747482
NRAS expression is associated with prognosis and tumor immune microenvironment in lung adenocarcinoma. PMID:34746975
Conditions for maintenance of hepatocyte differentiation and function in 3D cultures. PMID:34746700
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients. PMID:34746695
New Insights Into Human Hyaluronidase 4/Chondroitin Sulphate Hydrolase. PMID:34746156
SPTBN2, a New Biomarker of Lung Adenocarcinoma. PMID:34745988
Ral GEF with the PH Domain and SH3 Binding Motif 1 Regulated by Splicing Factor Junction Plakoglobin and Pyrimidine Metabolism Are Prognostic in Uterine Carcinosarcoma. PMID:34745385
The Oncogenic Role and Immune Infiltration for CARM1 Identified by Pancancer Analysis. PMID:34745258
Endoplasmic Reticulum-Based Calcium Dysfunctions in Synucleinopathies. PMID:34744980
Case Report: A False Negative Case of Anti-Yo Paraneoplastic Myelopathy. PMID:34744969
Systematic Review and Bioinformatic Analysis of microRNA Expression in Autism Spectrum Disorder Identifies Pathways Associated With Cancer, Metabolism, Cell Signaling, and Cell Adhesion. PMID:34744804
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders. PMID:34741163
Advances in integrative African genomics. PMID:34740451
Prognostic and Immune-Infiltrate Significance of miR-222-3p and Its Target Genes in Thyroid Cancer. PMID:34737762
A large Canadian cohort provides insights into the genetic architecture of human hair colour. PMID:34737440
COVID-19 and vertical transmission: assessing the expression of ACE2/TMPRSS2 in the human fetus and placenta to assess the risk of SARS-CoV-2 infection. PMID:34735736
Gene4HL: An Integrated Genetic Database for Hearing Loss. PMID:34733322
Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes. PMID:34732801
Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data. PMID:34732773
HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape. PMID:34732735
Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer's disease. PMID:34732252
Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation. PMID:34732054
p53/FBXL20 axis negatively regulates the protein stability of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase. PMID:34731788
Dissecting mammalian spermatogenesis using spatial transcriptomics. PMID:34731600
miR-146a modulates TLR1/2 and 4 induced inflammation and links it with proliferation and lipid production via the indirect regulation of GNG7 in human SZ95 sebocytes. PMID:34728702
Investigations into SCAMP5, a candidate lupus risk gene expressed in plasmacytoid dendritic cells. PMID:34728555
Expression profile of SARS-CoV-2 cellular entry proteins in normal oral mucosa and oral squamous cell carcinoma. PMID:34726347
Elimination of acquired resistance to PD-1 blockade via the concurrent depletion of tumour cells and immunosuppressive cells. PMID:34725506
Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma. PMID:34724892
SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values. PMID:34722629
A Systematic Review of Transcriptional Dysregulation in Huntington's Disease Studied by RNA Sequencing. PMID:34721539
An In-Silico, In-Vitro and In-Vivo Combined Approach to Identify NMNATs as Potential Protein Targets of ProEGCG for Treatment of Endometriosis. PMID:34721014
Path4Drug: Data Science Workflow for Identification of Tissue-Specific Biological Pathways Modulated by Toxic Drugs. PMID:34721010
Biomarkers for gastrointestinal adverse events related to thiopurine therapy. PMID:34720526
Dynamics of urinary and respiratory shedding of Severe acute respiratory syndrome virus 2 (SARS-CoV-2) RNA excludes urine as a relevant source of viral transmission. PMID:34716901
Human semen quality as affected by SARS-CoV-2 infection: An up-to-date review. PMID:34716614
High-throughput and high-efficiency sample preparation for single-cell proteomics using a nested nanowell chip. PMID:34716329
Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer. PMID:34715817
De novo identification of mammalian ciliary motility proteins using cryo-EM. PMID:34715025
A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease. PMID:34712920
CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum. PMID:34711653
SARS-CoV-2-host proteome interactions for antiviral drug discovery. PMID:34709727
Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia. PMID:34709177
Identification of a Prognosis-Related Risk Signature for Bladder Cancer to Predict Survival and Immune Landscapes. PMID:34708131
Analysing a Novel RNA-Binding-Protein-Related Prognostic Signature Highly Expressed in Breast Cancer. PMID:34707800
Non-Invasive Characterization of the Pancreas During Bariatric Surgery via Circulating Pancreatic Specific Cell-free Messenger RNA. PMID:34707641
Multi-Omics Analysis Identified TMED2 as a Shared Potential Biomarker in Six Subtypes of Human Cancer. PMID:34707394
Pathophysiological and diagnostic importance of fatty acid-binding protein 1 in heart failure with preserved ejection fraction. PMID:34707207
Concept and application of circulating proteasomes. PMID:34707192
Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors. PMID:34706560
Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults. PMID:34706549
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference. PMID:34705895
Characterisation of Levonorgestrel-Resistant Endometrial Cancer Cells. PMID:34703309
Bifunctional molecules targeting SARS-CoV-2 spike and the polymeric Ig receptor display neutralization activity and mucosal enrichment. PMID:34693867
Weighted Gene Co-expression Network Analysis Identifies a Cancer-Associated Fibroblast Signature for Predicting Prognosis and Therapeutic Responses in Gastric Cancer. PMID:34692770
Exploring Somatic Alteration Associating With Aggressive Behaviors of Papillary Thyroid Carcinomas by Targeted Sequencing. PMID:34692499
Identification of C3 and FN1 as potential biomarkers associated with progression and prognosis for clear cell renal cell carcinoma. PMID:34688260
NUAK Kinases: Brain-Ovary Axis. PMID:34685740
Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions. PMID:34684847
Cellular Protein Phosphatase 2A Regulates Cell Survival Mechanisms in Influenza A Virus Infection. PMID:34681823
Conserved Structure and Evolution of DPF Domain of PHF10-The Specific Subunit of PBAF Chromatin Remodeling Complex. PMID:34681795
The Heparanase Regulatory Network in Health and Disease. PMID:34681753
Mass Spectrometry-Based Proteomics Reveal Alcohol Dehydrogenase 1B as a Blood Biomarker Candidate to Monitor Acetaminophen-Induced Liver Injury. PMID:34681731
Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas. PMID:34680577
Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases. PMID:34680427
The Clinical and Theranostic Values of Activated Leukocyte Cell Adhesion Molecule (ALCAM)/CD166 in Human Solid Cancers. PMID:34680335
A Unified Transcriptional, Pharmacogenomic, and Gene Dependency Approach to Decipher the Biology, Diagnostic Markers, and Therapeutic Targets Associated with Prostate Cancer Metastasis. PMID:34680307
Probiotics and Trained Immunity. PMID:34680035
Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism. PMID:34678314
Prediction of severe adverse events, modes of action and drug treatments for COVID-19's complications. PMID:34675303
The nomogram based on the 6-lncRNA model can promote the prognosis prediction of patients with breast invasive carcinoma. PMID:34675301
Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases. PMID:34675204
Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome. PMID:34672947
Non-Coding RNA and Frizzled Receptors in Cancer. PMID:34671643
Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity? PMID:34671320
Myoglobin Protects Breast Cancer Cells Due to Its ROS and NO Scavenging Properties. PMID:34671319
COVID-19 disease and malignant cancers: The impact for the furin gene expression in susceptibility to SARS-CoV-2. PMID:34671211
Prognostic role of tumour-infiltrating lymphocytes and macrophages in relation to MSI, CDX2 and BRAF status: a population-based study of metastatic colorectal cancer patients. PMID:34671130
Differentially accessible, single copy sequences form contiguous domains along metaphase chromosomes that are conserved among multiple tissues. PMID:34670606
Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in colorectal cancer. PMID:34670584
Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project. PMID:34670092
Urinary proteomics investigations into contrast-induced acute kidney injury. PMID:34669736
Deciphering the link between Diabetes mellitus and SARS-CoV-2 infection through differential targeting of microRNAs in the human pancreas. PMID:34669152
Extracellular Domains of Transmembrane Proteins Defy the Expression Level-Evolutionary Rate Anticorrelation. PMID:34665250
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19. PMID:34663813
Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy. PMID:34663807
Quantifying full-length circular RNAs in cancer. PMID:34663689
Impact of genetic testing and smoking on the distribution of risk factors in patients with recurrent acute and chronic pancreatitis. PMID:34663162
Kappa but not delta or mu opioid receptors form homodimers at low membrane densities. PMID:34657173
Identification and quantification of immune infiltration landscape on therapy and prognosis in left- and right-sided colon cancer. PMID:34657172
Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation. PMID:34656824
Protecting the future: balancing proteostasis for reproduction. PMID:34654604
The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice. PMID:34653361
Urinary extracellular vesicles: Assessment of pre-analytical variables and development of a quality control with focus on transcriptomic biomarker research. PMID:34651466
Notch Intracellular Domain Plasmid Delivery via Poly(Lactic-Co-Glycolic Acid) Nanoparticles to Upregulate Notch Pathway Molecules. PMID:34651022
Identification of FAM107A as a potential biomarker and therapeutic target for prostate carcinoma. PMID:34650688
Meta-Analysis illustrates possible role of lipopolysaccharide (LPS)-induced tissue injury in nasopharyngeal carcinoma (NPC) pathogenesis. PMID:34648530
OncomiRs miR-106a and miR-17 negatively regulate the nucleoside-derived drug transporter hCNT1. PMID:34647142
Case Report: A Novel GNB1 Mutation Causes Global Developmental Delay With Intellectual Disability and Behavioral Disorders. PMID:34646230
Discovery of alternatively spliced isoforms and long non-coding RNA in full length brain transcriptomes of anadromous Hilsa shad, Tenualosa ilisha (Hamilton, 1822). PMID:34643921
hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage. PMID:34642383
Tissue Sampling and Homogenization in the Sub-Microliter Scale with a Nanosecond Infrared Laser (NIRL) for Mass Spectrometric Proteomics. PMID:34639174
The Distinct Properties of the Consecutive Disordered Regions Inside or Outside Protein Domains and Their Functional Significance. PMID:34639018
Molecular Insights into SARS-CoV2-Induced Alterations of the Gut/Brain Axis. PMID:34638785
Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation. PMID:34638511
Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity. PMID:34638503
Challenges and Prospects for Designer T and NK Cells in Glioblastoma Immunotherapy. PMID:34638471
Proteomic Landscape of Prostate Cancer: The View Provided by Quantitative Proteomics, Integrative Analyses, and Protein Interactomes. PMID:34638309
Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma. PMID:34638286
High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma. PMID:34635011
A metabolism-relevant signature as a predictor for prognosis and therapeutic response in pancreatic cancer. PMID:34632851
OnTheFly2.0: a text-mining web application for automated biomedical entity recognition, document annotation, network and functional enrichment analysis. PMID:34632381
Identification and Characterisation of cis-Regulatory Elements Upstream of the Human Receptor Tyrosine Kinase Gene MERTK. PMID:34631417
Promising Epigenetic Biomarkers Associated With Cancer-Associated-Fibroblasts for Progression of Kidney Renal Clear Cell Carcinoma. PMID:34630525
Chip Protein U-Box Domain Truncation Affects Purkinje Neuron Morphology and Leads to Behavioral Changes in Zebrafish. PMID:34630034
Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer. PMID:34628286
Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways. PMID:34624527
Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma. PMID:34621750
Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection. PMID:34621686
mRNA Network: Solution for Tracking Chemotherapy Insensitivity in Small-Cell Lung Cancer. PMID:34621500
Pitfalls and Common Findings in 68Ga-FAPI PET: A Pictorial Analysis. PMID:34620730
Testicular Nuclear Receptor 4 Regulates Proliferation and Apoptosis of Bladder Cancer via Bcl-2. PMID:34616769
Novel ACE2 protein interactions relevant to COVID-19 predicted by evolutionary rate correlations. PMID:34616619
CTHRC1 expression is a novel shared diagnostic and prognostic biomarker of survival in six different human cancer subtypes. PMID:34615943
EZH2 knockout in oral cavity basal epithelia causes more invasive squamous cell carcinomas. PMID:34614148
Low expression of endoplasmic reticulum stress-related gene SERP1 is associated with poor prognosis and immune infiltration in skin cutaneous melanoma. PMID:34613934
Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells. PMID:34611477
Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma. PMID:34607313
PRM-LIVE with Trapped Ion Mobility Spectrometry and Its Application in Selectivity Profiling of Kinase Inhibitors. PMID:34606255
PeptiCHIP: A Microfluidic Platform for Tumor Antigen Landscape Identification. PMID:34605646
Cancer chemoprevention through Frizzled receptors and EMT. PMID:34604862
SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma. PMID:34604392
PDZ Binding Kinase/T-LAK Cell-Derived Protein Kinase Plays an Oncogenic Role and Promotes Immune Escape in Human Tumors. PMID:34603451
Arginase-1 Released into CSF After Aneurysmal Subarachnoid Hemorrhage Decreases Arginine/Ornithine Ratio: a Novel Prognostic Biomarker. PMID:34599427
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity. PMID:34599178
Identification of Key Amino Acids that Impact Organic Solute Transporter α/β (OSTα/β). PMID:34599072
ATP-binding cassette transporters mediate differential biosynthesis of glycosphingolipid species. PMID:34597626
Dissecting Genomic Determinants of Positive Selection with an Evolution-Guided Regression Model. PMID:34597406
MBOAT1 homozygous missense variant causes nonobstructive azoospermia. PMID:34596601
circRPS16 Promotes Proliferation and Invasion of Hepatocellular Carcinoma by Sponging miR-876-5p to Upregulate SPINK1. PMID:34595116
Bioinformatics Analyses Reveal the Prognostic Value and Biological Roles of SEPHS2 in Various Cancers. PMID:34594130
Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia. PMID:34589087
Suppressor effect of catechol-O-methyltransferase gene in prostate cancer. PMID:34587154
Impact of depression and stress on placental DNA methylation in ethnically diverse pregnant women. PMID:34585950
UBE2S activates NF-κB signaling by binding with IκBα and promotes metastasis of lung adenocarcinoma cells. PMID:34582005
Enrichment of SARS-CoV-2 Entry Factors and Interacting Intracellular Genes in Tissue and Circulating Immune Cells. PMID:34578338
Cell Models for Chromosome 20q11.21 Amplification and Drug Sensitivities in Colorectal Cancer. PMID:34577783
Catenin Alpha 2 May Be a Biomarker or Potential Drug Target in Psychiatric Disorders with Perseverative Negative Thinking. PMID:34577549
LRP1B: A Giant Lost in Cancer Translation. PMID:34577535
The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes. PMID:34577099
Analysis of Molecular Networks in the Cerebellum in Chronic Schizophrenia: Modulation by Early Postnatal Life Stressors in Murine Models. PMID:34576238
Genomic and Ancestral Variation Underlies the Severity of COVID-19 Clinical Manifestation in Individuals of European Descent. PMID:34575070
The Phenotypic Spectrum of Patients with PHARC Syndrome Due to Variants in ABHD12: An Ophthalmic Perspective. PMID:34573385
Identifying Plectin Isoform Functions through Animal Models. PMID:34572100
Artificial Intelligence-Assisted Identification of Genetic Factors Predisposing High-Risk Individuals to Asymptomatic Heart Failure. PMID:34572079
Potential Therapeutic Effect of Micrornas in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2. PMID:34572043
Comprehensive Characterization of Multitissue Expression Landscape, Co-Expression Networks and Positive Selection in Pikeperch. PMID:34571938
Distinct gene-set burden patterns underlie common generalized and focal epilepsies. PMID:34571366
Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome. PMID:34570756
miRNATissueAtlas2: an update to the human miRNA tissue atlas. PMID:34570238
Construction of circRNA-based ceRNA network and its prognosis-associated subnet of clear cell renal cell carcinoma. PMID:34569727
Chromobox Homolog 8 (CBX8) in Human Tumor Carcinogenesis and Prognosis: A Pancancer Analysis Using Multiple Databases. PMID:34567093
Renal Lipid Metabolism Abnormalities in Obesity and Clear Cell Renal Cell Carcinoma. PMID:34564424
CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner. PMID:34563205
Mitogen-activated protein kinase-activated protein kinase-2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer. PMID:34559922
Antimicrobial protein REG3A and signaling networks are predictive of stroke outcomes. PMID:34558059
Early Leukocyte Responses in Ex-Vivo Models of Healing and Non-Healing Human Leishmania (Viannia) panamensis Infections. PMID:34557423
Expression and prognosis of CDC45 in cervical cancer based on the GEO database. PMID:34557356
SOX10 Knockdown Inhibits Melanoma Cell Proliferation via Notch Signaling Pathway. PMID:34557039
Path to improving the life cycle and quality of genome-scale models of metabolism. PMID:34555324
Pan-cancer proteogenomic investigations identify post-transcriptional kinase targets. PMID:34552204
Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoids. PMID:34548904
Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease. PMID:34548398
Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases. PMID:34548389
Sex Differences in the Role of CNIH3 on Spatial Memory and Synaptic Plasticity. PMID:34548146
Adipose tissue dysfunction and MAFLD in obesity on the scene of COVID-19. PMID:34543756
A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms. PMID:34541665
Association between the expression of core 3 synthase and survival outcomes of patients with cholangiocarcinoma. PMID:34539864
A Comprehensive Multiomics Analysis Identified Ubiquilin 4 as a Promising Prognostic Biomarker of Immune-Related Therapy in Pan-Cancer. PMID:34539785
Physical and Functional Interaction of Mitochondrial Single-Stranded DNA-Binding Protein and the Catalytic Subunit of DNA Polymerase Gamma. PMID:34539752
Impact of vitamin C supplementation on placental DNA methylation changes related to maternal smoking: association with gene expression and respiratory outcomes. PMID:34538263
Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers. PMID:34535764
DDX3X and DDX3Y are redundant in protein synthesis. PMID:34535544
Plasma fibulin-1 levels during pregnancy and delivery: a longitudinal observational study. PMID:34535108
Hepatic Regulator of G Protein Signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death. PMID:34534913
Proteogenomic characterization of pancreatic ductal adenocarcinoma. PMID:34534465
Acute Decompensated Heart Failure and the Kidney: Physiological, Histological and Transcriptomic Responses to Development and Recovery. PMID:34533033
Identifying the dynamic gene regulatory network during latent HIV-1 reactivation using high-dimensional ordinary differential equations. PMID:34531927
Multidimensional Analyses of Tumor Immune Microenvironment Reveal the Possible Rationality of Immunotherapy and Identify High Immunotherapy Response Subtypes for Renal Papillary Cell Carcinoma. PMID:34531849
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. PMID:34530870
Comparison of Multiple Clinical Testing Modalities for Assessment of NPM1-Mutant AML. PMID:34527579
The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson's Disease and Their Association With Disease State and Clinical Features. PMID:34526889
NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions. PMID:34525352
Quantitative characterization of tetraspanin 8 homointeractions in the plasma membrane. PMID:34524408
Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs. PMID:34520530
Affinity-based profiling of endogenous phosphoprotein phosphatases by mass spectrometry. PMID:34518704
DPYSL2 as potential diagnostic and prognostic biomarker linked to immune infiltration in lung adenocarcinoma. PMID:34517904
Platelets amplify endotheliopathy in COVID-19. PMID:34516880
The molecular mechanism of RIG-I activation and signaling. PMID:34514601
Contraceptive and Infertility Target DataBase: a contraceptive drug development tool for targeting and analysis of human reproductive specific tissues†. PMID:34514504
Integrative Epigenome Map of the Normal Human Prostate Provides Insights Into Prostate Cancer Predisposition. PMID:34513844
A Multiplex Thyroid-Specific Assay for Quantification of Circulating Thyroid Cell-Free RNA in Plasma of Thyroid Cancer Patients. PMID:34512731
Cross-Species and Human Inter-Tissue Network Analysis of Genes Implicated in Longevity and Aging Reveal Strong Support for Nutrient Sensing. PMID:34512728
ESPL1 Is a Novel Prognostic Biomarker Associated With the Malignant Features of Glioma. PMID:34512713
Comprehensive Analysis of the Expression and Prognosis for Laminin Genes in Ovarian Cancer. PMID:34512203
Stem/Proliferative and Differentiated Cells within Primary Murine Colonic Epithelium Display Distinct Intracellular Free Ca2+ Signal Codes. PMID:34510822
SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pathway. PMID:34509929
In silico exploration of enzymes involved in sialic acid biosynthesis and their possible role in SARS-CoV-2 infection. PMID:34506921
Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia. PMID:34504651
The Cancer Epitope Database and Analysis Resource: A Blueprint for the Establishment of a New Bioinformatics Resource for Use by the Cancer Immunology Community. PMID:34504503
Defining the Tumor Microenvironment by Integration of Immunohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry. PMID:34503228
Landscape of Bone Marrow Metastasis in Human Neuroblastoma Unraveled by Transcriptomics and Deep Multiplex Imaging. PMID:34503120
Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43266-283 in Glioblastoma Stem Cells. PMID:34503072
Tau Protein Interaction Partners and Their Roles in Alzheimer's Disease and Other Tauopathies. PMID:34502116
Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β. PMID:34499926
Longitudinal peripheral tissue RNA-Seq transcriptomic profiling, hyperalgesia, and wound healing in the rat plantar surgical incision model. PMID:34499774
A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships. PMID:34498060
Evaluation of the Oncogene Function of GOLPH3 and Correlated Regulatory Network in Lung Adenocarcinoma. PMID:34497755
Cells of the human intestinal tract mapped across space and time. PMID:34497389
Nonredundant, isoform-specific roles of HDAC1 in glioma stem cells. PMID:34494550
Reconstruction of the Cytokine Signaling in Lysosomal Storage Diseases by Literature Mining and Network Analysis. PMID:34490253
Identification of the Real Hub Gene and Construction of a Novel Prognostic Signature for Pancreatic Adenocarcinoma Based on the Weighted Gene Co-expression Network Analysis and Least Absolute Shrinkage and Selection Operator Algorithms. PMID:34490033
Serum Anti-PDLIM1 Autoantibody as Diagnostic Marker in Ovarian Cancer. PMID:34489945
Programmable RNA targeting with the single-protein CRISPR effector Cas7-11. PMID:34489594
Prognostic role of EGR1 in breast cancer: a systematic review. PMID:34488929
Protein degradation technology: a strategic paradigm shift in drug discovery. PMID:34488823
Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids. PMID:34487490
A pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers. PMID:34486492
Sour Taste SNP KCNJ2-rs236514 and Differences in Nutrient Intakes and Metabolic Health Markers in the Elderly. PMID:34485363
Adenine base editing of the DUX4 polyadenylation signal for targeted genetic therapy in facioscapulohumeral muscular dystrophy. PMID:34484861
A Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide. PMID:34481949
The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology. PMID:34476892
Whole blood transcriptomics identifies gene expression associated with peanut allergy in infants at high risk. PMID:34473385
Genome-Wide Phylogenetic Analysis, Expression Pattern, and Transcriptional Regulatory Network of the Pig C/EBP Gene Family. PMID:34471342
ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity. PMID:34471224
Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia. PMID:34471128
De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity. PMID:34470666
Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression. PMID:34467243
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study. PMID:34465810
Introducing Thioredoxin-Related Transmembrane Proteins: Emerging Roles of Human TMX and Clinical Implications. PMID:34465218
Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice. PMID:34462439
GSK2126458 has the potential to inhibit the proliferation of pancreatic cancer uncovered by bioinformatics analysis and pharmacological experiments. PMID:34461940
A multi-objective genetic algorithm to find active modules in multiplex biological networks. PMID:34460810
TIAMMAt: Leveraging Biodiversity to Revise Protein Domain Models, Evidence from Innate Immunity. PMID:34459919
High mRNA Expression of CENPL and Its Significance in Prognosis of Hepatocellular Carcinoma Patients. PMID:34457090
Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson-Gilford Progeria syndrome. PMID:34453483
Proteomic discovery of non-invasive biomarkers of localized prostate cancer using mass spectrometry. PMID:34453155
The Cysteine-Containing Cell-Penetrating Peptide AP Enables Efficient Macromolecule Delivery to T Cells and Controls Autoimmune Encephalomyelitis. PMID:34452095
Selective Moonlighting Cell-Penetrating Peptides. PMID:34452080
Variable Distribution of DOCK-D Proteins between Cytosol and Nucleoplasm in Cell Lines, Effect of Interleukin-4 on DOCK10 in B-Cell Lymphoid Neoplasms, and Validation of a New DOCK10 Antiserum for Immunofluorescence Studies. PMID:34449554
Special Considerations in the Management of Autoimmune Hepatitis in COVID-19 Hotspots: A Review. PMID:34447687
CEACAM Gene Family Mutations Associated With Inherited Breast Cancer Risk - A Comparative Oncology Approach to Discovery. PMID:34447411
Role of β-Adrenergic Receptors and Estrogen in Cardiac Repair after Myocardial Infarction: An Overview. PMID:34445662
Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis. PMID:34445502
Investigation of LINC00493/SMIM26 Gene Suggests Its Dual Functioning at mRNA and Protein Level. PMID:34445188
The Histone Variant MacroH2A1 Impacts Circadian Gene Expression and Cell Phenotype in an In Vitro Model of Hepatocellular Carcinoma. PMID:34440260
Survival-Based Biomarker Module Identification Associated with Oral Squamous Cell Carcinoma (OSCC). PMID:34439992
Profiling Human CD55 Transgene Performance Assist in Selecting Best Suited Specimens and Tissues for Swine Organ Xenotransplantation. PMID:34439979
Cell Adhesion Molecules in Normal Skin and Melanoma. PMID:34439879
Impact of EcSOD Perturbations in Cancer Progression. PMID:34439467
Molecular Changes Induced in Melanoma by Cell Culturing in 3D Alginate Hydrogels. PMID:34439267
An Adverse Outcomes Approach to Study the Effects of SARS-CoV-2 in 3D Organoid Models. PMID:34437890
Bothrops Jararaca Snake Venom Modulates Key Cancer-Related Proteins in Breast Tumor Cell Lines. PMID:34437390
The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children. PMID:34437303
Rush Hour of LATs towards Their Transport Cycle. PMID:34436365
Lipid Transporters Beam Signals from Cell Membranes. PMID:34436325
Distinct contributions of meprins to skin regeneration after injury - Meprin α a physiological processer of pro-collagen VII. PMID:34435182
COVID-19 infection and liver injury: Clinical features, biomarkers, potential mechanisms, treatment, and management challenges. PMID:34434987
Identification of a Costimulatory Molecule Gene Signature to Predict Survival and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma. PMID:34434928
Identification of a circRNA-miRNA-mRNA regulatory network for exploring novel therapeutic options for glioma. PMID:34434651
Transcriptome Atlas of 16 Donkey Tissues. PMID:34434218
Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry. PMID:34431042
SCD1, autophagy and cancer: implications for therapy. PMID:34429143
What can the neurological manifestations of COVID-19 tell us: a meta-analysis. PMID:34425827
DeepHistoClass: A Novel Strategy for Confident Classification of Immunohistochemistry Images Using Deep Learning. PMID:34425263
Arginase-1 and P-glycoprotein are downregulated in canine hepatocellular carcinoma. PMID:34423599
CD86 Molecule Might Be a Novel Immune-Related Prognostic Biomarker for Patients With Bladder Cancer by Bioinformatics and Experimental Assays. PMID:34422632
Identification of Candidate Biomarkers and Prognostic Analysis in Colorectal Cancer Liver Metastases. PMID:34422629
Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes. PMID:34419158
The relationship between transforming growth factor β superfamily members (GDF11 and BMP4) and lumbar spine bone mineral density in postmenopausal Chinese women. PMID:34417839
Characteristic of molecular subtypes in lung adenocarcinoma based on m6A RNA methylation modification and immune microenvironment. PMID:34416861
Backbone and nearly complete side-chain chemical shift assignments reveal the human uncharacterized protein CXorf51A as intrinsically disordered. PMID:34415548
Biallelic PI4KA variants cause neurological, intestinal and immunological disease. PMID:34415310
Roles of α‑synuclein in gastrointestinal microbiome dysbiosis‑related Parkinson's disease progression (Review). PMID:34414447
DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma. PMID:34414037
TET2 as a tumor suppressor and therapeutic target in T-cell acute lymphoblastic leukemia. PMID:34413196
Screening of DNA Damage Repair Genes Involved in the Prognosis of Triple-Negative Breast Cancer Patients Based on Bioinformatics. PMID:34408776
Targeting AXL in NSCLC. PMID:34408519
Survival analysis in breast cancer using proteomic data from four independent datasets. PMID:34408238
Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids. PMID:34407934
Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease. PMID:34406858
A Diazirine-Modified Membrane Lipid to Study Peptide/Lipid Interactions - Chances and Challenges. PMID:34406694
Diagnosis and prognostic value of C-X-C motif chemokine ligand 1 in colon adenocarcinoma based on The Cancer Genome Atlas and Guangxi cohort. PMID:34405013
TMEM16F and dynamins control expansive plasma membrane reservoirs. PMID:34404808
ZNF768 links oncogenic RAS to cellular senescence. PMID:34404770
Bioinformatics analysis of the transcriptional expression of minichromosome maintenance proteins as potential indicators of survival in patients with cervical cancer. PMID:34404366
Immunopeptidomics toolkit library (IPTK): a python-based modular toolbox for analyzing immunopeptidomics data. PMID:34404349
ZSWIM7 Is Associated With Human Female Meiosis and Familial Primary Ovarian Insufficiency. PMID:34402903
Identification of prognostic and bone metastatic alternative splicing signatures in bladder cancer. PMID:34402716
SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release. PMID:34401873
Cell type-selective targeted delivery of a recombinant lysosomal enzyme for enzyme therapies. PMID:34400331
Comprehensive Analysis of CD163 as a Prognostic Biomarker and Associated with Immune Infiltration in Glioblastoma Multiforme. PMID:34395626
Identification of a Gene Set Correlated With Immune Status in Ovarian Cancer by Transcriptome-Wide Data Mining. PMID:34395521
Proteomic analysis reveals some common proteins in the kidney stone matrix. PMID:34395096
Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples. PMID:34392148
Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias: genetics in inguinal hernias. PMID:34392144
Production of 11-Oxygenated Androgens by Testicular Adrenal Rest Tumors. PMID:34390337
Patients with PWS and related syndromes display differentially methylated regions involved in neurodevelopmental and nutritional trajectory. PMID:34389046
NBAS Variants Are Associated with Quantitative and Qualitative NK and B Cell Deficiency. PMID:34386911
MEF2C Common Genetic Variation Is Associated With Different Aspects of Cognition in Non-Hispanic White and Caribbean Hispanic Non-demented Older Adults. PMID:34386032
Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions. PMID:34385445
The role of basement membranes in cardiac biology and disease. PMID:34382650
Use of a neuron-glia genome-scale metabolic reconstruction to model the metabolic consequences of the Arylsulphatase a deficiency through a systems biology approach. PMID:34381909
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer. PMID:34381029
Cell therapy strategies for COVID-19: Current approaches and potential applications. PMID:34380619
Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer. PMID:34378678
Phase Ib study of patients with metastatic castrate-resistant prostate cancer treated with different sequencing regimens of atezolizumab and sipuleucel-T. PMID:34376554
The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells. PMID:34374812
Emerging protein degradation strategies: expanding the scope to extracellular and membrane proteins. PMID:34373745
Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19. PMID:34372575
Glutamate receptor, ionotropic, N‑methyl D‑aspartate‑associated protein 1 promotes colorectal cancer cell proliferation and metastasis, and is negatively regulated by miR‑296‑3p. PMID:34368871
DeepFeature: feature selection in nonimage data using convolutional neural network. PMID:34368836
Shared genomic segment analysis in a large high-risk chronic lymphocytic leukemia pedigree implicates CXCR4 in inherited risk. PMID:34368645
Identification and Validation of PIK3CA as a Marker Associated with Prognosis and Immune Infiltration in Renal Clear Cell Carcinoma. PMID:34367282
Netrin-1 in Glioblastoma Neovascularization: The New Partner in Crime? PMID:34361013
SARS-CoV-2 Infected Pediatric Cerebral Cortical Neurons: Transcriptomic Analysis and Potential Role of Toll-like Receptors in Pathogenesis. PMID:34360824
The Interactome of the VAP Family of Proteins: An Overview. PMID:34359948
TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions. PMID:34359920
The Role of DND1 in Cancers. PMID:34359581
Dysregulation of PI3K/Akt/PTEN Pathway in Canine Mammary Tumor. PMID:34359206
Basic principles of hydrogel-based tissue transformation technologies and their applications. PMID:34358468
Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification. PMID:34358453
Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines. PMID:34358150
No Evidence for the Involvement of Leiomodin-1 Antibodies in the Pathogenesis of Onchocerciasis-Associated Epilepsy. PMID:34357995
Structure, Activity and Function of the Suv39h1 and Suv39h2 Protein Lysine Methyltransferases. PMID:34357075
Battle Royale: Innate Recognition of Poxviruses and Viral Immune Evasion. PMID:34356829
Loss of the MAF Transcription Factor in Laryngeal Squamous Cell Carcinoma. PMID:34356658
FLAME: A Web Tool for Functional and Literature Enrichment Analysis of Multiple Gene Lists. PMID:34356520
Biosynthesis, Quantification and Genetic Diseases of the Smallest Signaling Thiol Metabolite: Hydrogen Sulfide. PMID:34356298
Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations. PMID:34356065
Pipelines and Systems for Threshold-Avoiding Quantification of LC-MS/MS Data. PMID:34355890
A size-exclusion-based approach for purifying extracellular vesicles from human plasma. PMID:34355211
Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent. PMID:34354587
An Immune-Related Gene-Based Signature as Prognostic Tool in Ovarian Serous Cystadenocarcinoma. PMID:34354370
Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids. PMID:34354063
Precision genetic cellular models identify therapies protective against ER stress. PMID:34354042
The RNA-binding protein and stress granule component ATAXIN-2 is expressed in mouse and human tissues associated with glaucoma pathogenesis. PMID:34350994
Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease. PMID:34350953
Directed differentiation of human pluripotent stem cells into epidermal stem and progenitor cells. PMID:34350551
Characterization of Five Transmembrane Proteins: With Focus on the Tweety, Sideroflexin, and YIP1 Domain Families. PMID:34350187
The Impact of the COVID-19 Pandemic on Dementia Risk: Potential Pathways to Cognitive Decline. PMID:34348321
Prognostic Impact of MITD1 and Associates With Immune Infiltration in Kidney Renal Clear Cell Carcinoma. PMID:34346239
In silico assessment of EpCAM transcriptional expression and determination of the prognostic biomarker for human lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). PMID:34345719
Comprehensive analysis of the expression and prognosis for TNFAIPs in head and neck cancer. PMID:34344926
Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders. PMID:34344888
Identification and integrative analysis of ACLY and related gene panels associated with immune microenvironment reveal prognostic significance in hepatocellular carcinoma. PMID:34344378
Semper's cells in the insect compound eye: Insights into ocular form and function. PMID:34343526
A Potential miRNA-mRNA Network for Dementia and Hernia Crosstalk. PMID:34341761
Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells. PMID:34339458
Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies. PMID:34338426
Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis. PMID:34338148
CDH12 as a Candidate Gene for Kidney Injury in Posterior Urethral Valve Cases: A Genome-wide Association Study Among Patients with Obstructive Uropathies. PMID:34337522
Genetic syndromes with vascular malformations - update on molecular background and diagnostics. PMID:34336026
Mapping Autoantibodies in Children With Acute Rheumatic Fever. PMID:34335616
Role of Hydrogen Sulfide in the Endocrine System. PMID:34335475
Cardiovascular Effects Mediated by HMMR and CD44. PMID:34335086
Nucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma. PMID:34334108
Vitamin D supplementation in people with IBS has no effect on symptom severity and quality of life: results of a randomised controlled trial. PMID:34328539
Genome wide DNA methylation analysis of alveolar capillary dysplasia lung tissue reveals aberrant methylation of genes involved in development including the FOXF1 locus. PMID:34325731
DNA methylation differences in cortical grey and white matter in schizophrenia. PMID:34323598
The application of cytokeratin-18 as a biomarker for drug-induced liver injury. PMID:34322741
Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V. PMID:34322157
Exploiting Single-Cell Tools in Gene and Cell Therapy. PMID:34322133
A single-cell type transcriptomics map of human tissues. PMID:34321199
Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma. PMID:34320917
Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis. PMID:34320216
The Src-family Kinase Lyn in Immunoreceptor Signaling. PMID:34320188
The Indirect Antiviral Potential of Long Noncoding RNAs Encoded by IFITM Pseudogenes. PMID:34319781
Toward Comprehensive Plasma Proteomics by Orthogonal Protease Digestion. PMID:34319755
Functionathon: a manual data mining workflow to generate functional hypotheses for uncharacterized human proteins and its application by undergraduate students. PMID:34318869
A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis. PMID:34318286
Reboot: a straightforward approach to identify genes and splicing isoforms associated with cancer patient prognosis. PMID:34316711
Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond. PMID:34316690
SRSF10: an atypical splicing regulator with critical roles in stress response, organ development, and viral replication. PMID:34315816
Mapping the miRNA-mRNA Interactome in Human Hepatocytes and Identification of Functional mirSNPs in Pharmacogenes. PMID:34314509
Chalcone-Supported Cardiac Mesoderm Induction in Human Pluripotent Stem Cells for Heart Muscle Engineering. PMID:34309224
Guillain-Barré syndrome associated with Covid-19: A close relationship or just a coincidence? (Review). PMID:34306190
Study on HOXBs of Clear Cell Renal Cell Carcinoma and Detection of New Molecular Target. PMID:34306077
Circadian Genes as Exploratory Biomarkers in DMD: Results From Both the mdx Mouse Model and Patients. PMID:34305639
Ligand-directed bias of G protein signaling at the dopamine D2 receptor. PMID:34302750
The clinical importance of tandem exon duplication-derived substitutions. PMID:34302486
YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion. PMID:34301937
Knock-Out of ACBD3 Leads to Dispersed Golgi Structure, but Unaffected Mitochondrial Functions in HEK293 and HeLa Cells. PMID:34298889
Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking. PMID:34297830
Web tools to perform long non-coding RNAs analysis in oncology research. PMID:34296748
NEK7 Promotes Pancreatic Cancer Progression And Its Expression Is Correlated With Poor Prognosis. PMID:34295827
Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression. PMID:34294073
Powerful detection of polygenic selection and evidence of environmental adaptation in US beef cattle. PMID:34292938
ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease. PMID:34290711
CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. PMID:34290169
Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression. PMID:34290087
Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinoma. PMID:34290079
Early intrahepatic duct defects in a cystic fibrosis porcine model. PMID:34288572
Abnormal Liver Biochemistry Tests and Acute Liver Injury in COVID-19 Patients: Current Evidence and Potential Pathogenesis. PMID:34287285
WNT8B as an Independent Prognostic Marker for Nasopharyngeal Carcinoma. PMID:34287269
Altered expression of genes controlling metabolism characterizes the tissue response to immune injury in lupus. PMID:34285256
Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer. PMID:34285249
The role of FOSL1 in stem-like cell reprogramming processes. PMID:34282187
Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin. PMID:34282151
Functional annotation of noncoding mutations in cancer. PMID:34282050
The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition). PMID:34277994
PLXNC1: A Novel Potential Immune-Related Target for Stomach Adenocarcinoma. PMID:34277610
RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in Macrophages via Regulating Histone H3K4 Trimethylation. PMID:34276666
Novel urine biomarkers to distinguish UTI from culture-negative pyuria. PMID:34272611
Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma. PMID:34272452
Prioritizing and characterizing functionally relevant genes across human tissues. PMID:34270548
Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects. PMID:34267199
CK2-mediated phosphorylation of Che-1/AATF is required for its pro-proliferative activity. PMID:34266450
Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2. PMID:34265358
Metastatic heterogeneity of the consensus molecular subtypes of colorectal cancer. PMID:34262039
CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression. PMID:34262017
Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples. PMID:34261731
Expression of Transcription Factor CREM in Human Tissues. PMID:34261344
Identification of Potential Biomarkers From Hepatocellular Carcinoma With MT1 Deletion. PMID:34257549
From Flatland to Jupiter: Searching for Rules of Interaction Across Biological Scales. PMID:34254127
The role of genetic polymorphisms in endolysosomal ion channels TPC2 and P2RX4 in cancer pathogenesis, prognosis, and diagnosis: a genetic association in the UK Biobank. PMID:34253731
Telomere-to-telomere assembly of a fish Y chromosome reveals the origin of a young sex chromosome pair. PMID:34253240
Characterization of a member of the CEACAM protein family as a novel marker of proton pump-rich ionocytes on the zebrafish epidermis. PMID:34252160
A novel high-throughput screen for identifying lipids that stabilise membrane proteins in detergent based solution. PMID:34252116
Urethral Catheter Biofilms Reveal Plasticity in Bacterial Composition and Metabolism and Withstand Host Immune Defenses in Hypoxic Environment. PMID:34249966
Identification of an Metabolic Related Risk Signature Predicts Prognosis in Cervical Cancer and Correlates With Immune Infiltration. PMID:34249930
Role of NRP1 in Bladder Cancer Pathogenesis and Progression. PMID:34249735
Glycolysis-Related Gene Expression Profiling Screen for Prognostic Risk Signature of Pancreatic Ductal Adenocarcinoma. PMID:34249078
ANANSE: an enhancer network-based computational approach for predicting key transcription factors in cell fate determination. PMID:34244796
Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement. PMID:34242919
SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes. PMID:34241597
Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip. PMID:34239116
Protein Secretion Prediction Tools and Extracellular Vesicles Databases. PMID:34236664
Deciphering Network Crosstalk: The Current Status and Potential of miRNA Regulatory Networks on the HSP40 Molecular Chaperone Network. PMID:34234816
An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism. PMID:34234248
NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. PMID:34233163
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma. PMID:34231338
GNRH1 and LTB4R might be novel immune-related prognostic biomarkers in clear cell renal cell carcinoma (ccRCC). PMID:34229684
Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells. PMID:34227245
Chromatin states shaped by an epigenetic code confer regenerative potential to the mouse liver. PMID:34226551
Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment. PMID:34221871
The N-Formyl Peptide Receptors and Rheumatoid Arthritis: A Dangerous Liaison or Confusing Relationship? PMID:34220836
The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019. PMID:34217339
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour. PMID:34211149
VECTOR: An Integrated Correlation Network Database for the Identification of CeRNA Axes in Uveal Melanoma. PMID:34210067
AKT Signaling Modifies the Balance between Cell Proliferation and Migration in Neural Crest Cells from Patients Affected with Bosma Arhinia and Microphthalmia Syndrome. PMID:34209568
Identification of Potential Biomarkers and Biological Pathways for Poor Clinical Outcome in Mucinous Colorectal Adenocarcinoma. PMID:34208938
NOX2 Activation in COVID-19: Possible Implications for Neurodegenerative Diseases. PMID:34208136
SRPassing Co-translational Targeting: The Role of the Signal Recognition Particle in Protein Targeting and mRNA Protection. PMID:34208095
The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout-An Update. PMID:34206432
Exploring the Metabolic Heterogeneity of Cancers: A Benchmark Study of Context-Specific Models. PMID:34205912
Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and Increases the Prevalence of Morphologically Abnormal Spermatozoa. PMID:34205849
Nectin-1 Expression Correlates with the Susceptibility of Malignant Melanoma to Oncolytic Herpes Simplex Virus In Vitro and In Vivo. PMID:34205379
Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity. PMID:34205207
Targeted Treatment of Head and Neck (Pre)Cancer: Preclinical Target Identification and Development of Novel Therapeutic Applications. PMID:34204886
A Conceptual Framework for Integrating Cellular Protein Folding, Misfolding and Aggregation. PMID:34202456
RGS14 Regulation of Post-Synaptic Signaling and Spine Plasticity in Brain. PMID:34201943
Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein. PMID:34201556
Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential. PMID:34201472
The Antimicrobial Activity of Peripheral Blood Neutrophils Is Altered in Patients with Primary Ciliary Dyskinesia. PMID:34201048
Systematic Review of Pharmacogenetic Factors That Influence High-Dose Methotrexate Pharmacokinetics in Pediatric Malignancies. PMID:34200242
The Diagnostic Journey of a Patient with Prader-Willi-Like Syndrome and a Unique Homozygous SNURF-SNRPN Variant; Bio-Molecular Analysis and Review of the Literature. PMID:34200226
Genome-Wide Differential Methylation Profiles from Two Terpene-Rich Medicinal Plant Extracts Administered in Osteoarthritis Rats. PMID:34199631
Elucidating the Mechanism of Action of the Attributed Immunomodulatory Role of Eltrombopag in Primary Immune Thrombocytopenia: An In Silico Approach. PMID:34199099
Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25. PMID:34198503
Passive transfer of fibromyalgia symptoms from patients to mice. PMID:34196305
SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes. PMID:34196300
Structural basis of the selective activation of enzyme isoforms: Allosteric response to activators of β1- and β2-containing AMPK complexes. PMID:34194666
TGM4: an immunogenic prostate-restricted antigen. PMID:34193566
A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity. PMID:34192532
Shaping Up Mitochondria in Diabetic Nephropathy. PMID:34189465
Non-permissive SARS-CoV-2 infection in human neurospheres. PMID:34186311
Targeting neuropilins as a viable SARS-CoV-2 treatment. PMID:34185437
Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study. PMID:34180758
A Comprehensive Analysis of the Downregulation of miRNA-1827 and Its Prognostic Significance by Targeting SPTBN2 and BCL2L1 in Ovarian Cancer. PMID:34179092
SARS-CoV-2 Host Receptor ACE2 Protein Expression Atlas in Human Gastrointestinal Tract. PMID:34178985
Meta-Analysis of Smooth Muscle Lineage Transcriptomes in Atherosclerosis and Their Relationships to In Vitro Models. PMID:34178388
Assembling Disease Networks From Causal Interaction Resources. PMID:34178043
Whole-Exome Sequencing Analysis of Human Semen Quality in Russian Multiethnic Population. PMID:34178030
Malignant cerebral infarction associated with COVID-19 in a child. PMID:34175976
ELIXIR: Providing a Sustainable Infrastructure for Life Science Data at European Scale. PMID:34175941
A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action. PMID:34173964
Dysregulation of the secretory pathway connects Alzheimer's disease genetics to aggregate formation. PMID:34171228
FINER: enhancing the prediction of tissue-specific functions of isoforms by refining isoform interaction networks. PMID:34169280
Identification of a Locus on the X Chromosome Linked to Familial Membranous Nephropathy. PMID:34169208
In silico analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients. PMID:34168096
SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19. PMID:34161337
Phosphatidylserine Receptors Enhance SARS-CoV-2 Infection: AXL as a Therapeutic Target for COVID-19. PMID:34159331
Super-resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement. PMID:34156149
Single-Nucleus RNA Sequencing Identifies New Classes of Proximal Tubular Epithelial Cells in Kidney Fibrosis. PMID:34155061
Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation. PMID:34154587
Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study. PMID:34151794
Protein and Microbial Biomarkers in Sputum Discern Acute and Latent Tuberculosis in Investigation of Pastoral Ethiopian Cohort. PMID:34150670
A Poliovirus Receptor (CD155)-Related Risk Signature Predicts the Prognosis of Bladder Cancer. PMID:34150627
Upregulation of LIMK1 Is Correlated With Poor Prognosis and Immune Infiltrates in Lung Adenocarcinoma. PMID:34149814
CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients. PMID:34149710
Synthesis, biological evaluation, molecular modeling, and structural analysis of new pyrazole and pyrazolone derivatives as N-formyl peptide receptors agonists. PMID:34148303
AdaTiSS: A Novel Data-Adaptive Robust Method for Identifying Tissue Specificity Scores. PMID:34146104
Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype. PMID:34145395
Analyzing cancer gene expression data through the lens of normal tissue-specificity. PMID:34143767
Endosomes as Signaling Platforms for IL-6 Family Cytokine Receptors. PMID:34141712
Using Tumor-Infiltrating Immune Cells and a ceRNA Network Model to Construct a Prognostic Analysis Model of Thyroid Carcinoma. PMID:34141614
Key Macrophage Responses to Infection With Mycobacterium tuberculosis Are Co-Regulated by microRNAs and DNA Methylation. PMID:34140955
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. PMID:34140493
Current Methodological Challenges of Single-Cell and Single-Nucleus RNA-Sequencing in Glomerular Diseases. PMID:34140401
Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (1): specific signatures of stromal, glandular and luminal epithelial cells. PMID:34139994
STING pathway expression in low-grade serous carcinoma of the ovary: an unexpected therapeutic opportunity? PMID:34138519
BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae. PMID:34137374
Identification of Genes Related to Immune Infiltration in the Tumor Microenvironment of Cutaneous Melanoma. PMID:34136377
pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis. PMID:34135065
Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome. PMID:34131099
Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease. PMID:34129723
Independent duplications of the Golgi phosphoprotein 3 oncogene in birds. PMID:34127736
Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells. PMID:34125594
Mechanisms of Neoantigen-Targeted Induction of Pyroptosis and Ferroptosis: From Basic Research to Clinical Applications. PMID:34123855
Demographics and risk factors for pediatric recurrent acute pancreatitis. PMID:34120130
Protein Microarrays for Ocular Diseases. PMID:34115364
Analysis of Protein-Protein Interactions by Protein Microarrays. PMID:34115353
Haploinsufficiency of ARFGEF1 is associated with developmental delay, intellectual disability, and epilepsy with variable expressivity. PMID:34113008
Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms. PMID:34112237
A meta-analysis of transcriptomic profiles of Huntington's disease patients. PMID:34111223
Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis. PMID:34110423
Machine learning-aided protein identification from multidimensional signatures. PMID:34109955
Differential Regulation of GPCRs-Are GRK Expression Levels the Key? PMID:34109182
Specialty Grand Challenge for Molecular Signalling and Pathways in Molecular Neuroscience. PMID:34108865
60 Years Young: The Evolving Role of Allogeneic Hematopoietic Stem Cell Transplantation in Cancer Immunotherapy. PMID:34108142
Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer. PMID:34108014
Identification of DNA methylation biomarkers for risk of liver metastasis in early-stage colorectal cancer. PMID:34108011
Tissue- and stage-specific landscape of the mouse translatome. PMID:34107020
CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes. PMID:34106789
A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy. PMID:34106735
Development of Parallel Reaction Monitoring Assays for the Detection of Aggressive Prostate Cancer Using Urinary Glycoproteins. PMID:34106707
Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease. PMID:34100423
Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease. PMID:34100014
A metabolic modeling approach reveals promising therapeutic targets and antiviral drugs to combat COVID-19. PMID:34099831
HOXA13 in etiology and oncogenic potential of Barrett's esophagus. PMID:34099670
miR-105-5p regulates PD-L1 expression and tumor immunogenicity in gastric cancer. PMID:34098061
Low Expression of RILPL2 Predicts Poor Prognosis and Correlates With Immune Infiltration in Endometrial Carcinoma. PMID:34095226
ITGA3 Is Associated With Immune Cell Infiltration and Serves as a Favorable Prognostic Biomarker for Breast Cancer. PMID:34094951
Metabolic protein phosphoglycerate kinase 1 confers lung cancer migration by directly binding HIV Tat specific factor 1. PMID:34091600
Aquaporins in insulin resistance and diabetes: More than channels! PMID:34090243
Proteomics-Based Insights Into the SARS-CoV-2-Mediated COVID-19 Pandemic: A Review of the First Year of Research. PMID:34089862
Tumor cells express pauci- and oligomannosidic N-glycans in glycoproteins recognized by the mannose receptor (CD206). PMID:34089345
Vertical transmission of SARS-CoV-2: A prospective cross-sectional study from a tertiary center. PMID:34081331
A proximity-dependent biotinylation map of a human cell. PMID:34079125
Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability. PMID:34078926
NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA. PMID:34078910
Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis. PMID:34078402
COVID-19 disrupts spermatogenesis through the oxidative stress pathway following induction of apoptosis. PMID:34076792
PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2). PMID:34075397
Broad auto-reactive IgM responses are common in critically ill patients, including those with COVID-19. PMID:34075365
Evolution and function of the epithelial cell-specific ER stress sensor IRE1β. PMID:34075183
Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation. PMID:34074730
Principles and Current Clinical Landscape of Multispecific Antibodies against Cancer. PMID:34073188
NKL Homeobox Gene VENTX Is Part of a Regulatory Network in Human Conventional Dendritic Cells. PMID:34072771
In-Silico Evaluation of Genetic Alterations in Ovarian Carcinoma and Therapeutic Efficacy of NSC777201, as a Novel Multi-Target Agent for TTK, NEK2, and CDK1. PMID:34072728
Ubiquitin Proteasome Pathway Transcriptome in Epithelial Ovarian Cancer. PMID:34071321
Identification of Candidate Protein Biomarkers for CIN2+ Lesions from Self-Sampled, Dried Cervico-Vaginal Fluid Using LC-MS/MS. PMID:34070587
A Synthetic Peptide CTL Vaccine Targeting Nucleocapsid Confers Protection from SARS-CoV-2 Challenge in Rhesus Macaques. PMID:34070152
foxm1 Modulates Cell Non-Autonomous Response in Zebrafish Skeletal Muscle Homeostasis. PMID:34070077
Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives. PMID:34067719
The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma. PMID:34067658
Oncogenic Potential of the Dual-Function Protein MEX3A. PMID:34067172
Western Diet Induced Remodelling of the Tongue Proteome. PMID:34066295
Cascading from SARS-CoV-2 to Parkinson's Disease through Protein-Protein Interactions. PMID:34066091
Network Pharmacological Analysis through a Bioinformatics Approach of Novel NSC765600 and NSC765691 Compounds as Potential Inhibitors of CCND1/CDK4/PLK1/CD44 in Cancer Types. PMID:34063946
BHK-21 Cell Clones Differ in Chikungunya Virus Infection and MXRA8 Receptor Expression. PMID:34063936
The Potential Protective Role of RUNX1 in Nonalcoholic Fatty Liver Disease. PMID:34063472
Advances and perspectives in discovery and functional analysis of small secreted proteins in plants. PMID:34059650
In vivo gene editing via homology-independent targeted integration for adrenoleukodystrophy treatment. PMID:34058389
Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin. PMID:34057753
Autophagy and ALS: mechanistic insights and therapeutic implications. PMID:34057020
Native-like SARS-CoV-2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine. PMID:34056089
CBFβ promotes colorectal cancer progression through transcriptionally activating OPN, FAM129A, and UPP1 in a RUNX2-dependent manner. PMID:34050318
Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer. PMID:34047812
Quantitative proteomic biomarkers from extracellular vesicles of human seminal plasma in the differential diagnosis of azoospermia. PMID:34047465
Assessing the functional relevance of splice isoforms. PMID:34046593
Decoding Neuromuscular Disorders Using Phenotypic Clusters Obtained From Co-Occurrence Networks. PMID:34046427
A Novel Ferroptosis Related Gene Signature for Prognosis Prediction in Patients With Colon Cancer. PMID:34046350
Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1. PMID:34041485
GWENA: gene co-expression networks analysis and extended modules characterization in a single Bioconductor package. PMID:34034647
The Human Salivary Proteome Wiki: A Community-Driven Research Platform. PMID:34032471
Tutorial: guidelines for annotating single-cell transcriptomic maps using automated and manual methods. PMID:34031612
Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo. PMID:34031270
Integrative analysis of the human brain mural cell transcriptome. PMID:34027687
Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity. PMID:34027339
Functional Variants Surrounding Endothelin 2 Are Associated With Mycobacterium avium Subspecies paratuberculosis Infection. PMID:34026885
Cellular Mechanisms of Liver Fibrosis. PMID:34025430
SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ferroptosis, endoplasmic reticulum stress and DNA synthesis. PMID:34023458
Up-regulated RFC2 predicts unfavorable progression in hepatocellular carcinoma. PMID:34022962
Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets. PMID:34022127
Genetic mapping of metabolic traits in the blind Mexican cavefish reveals sex-dependent quantitative trait loci associated with cave adaptation. PMID:34020589
µ-Crystallin: A thyroid hormone binding protein. PMID:34020530
Comprehensive analysis of the prognostic value and immune function of the IDO1 gene in gynecological cancers. PMID:34017374
Identification and Validation of a Six Immune-Related Genes Signature for Predicting Prognosis in Patients With Stage II Colorectal Cancer. PMID:34017356
Divergent Dimethylarginine Dimethylaminohydrolase Isoenzyme Expression in the Central Nervous System. PMID:34014421
Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival. PMID:34013359
An Exploration of the Tumor Microenvironment Identified a Novel Five-Gene Model for Predicting Outcomes in Bladder Cancer. PMID:34012914
Novel Alzheimer's disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers. PMID:34011927
A method to delineate de novo missense variants across pathways prioritizes genes linked to autism. PMID:34011629
Critical appraisal of the mechanisms of gastrointestinal and hepatobiliary infection by COVID-19. PMID:34009033
The selective alpha7 nicotinic acetylcholine receptor agonist AR-R17779 does not affect ischemia-reperfusion brain injury in mice. PMID:34008839
Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris. PMID:34003106
Downregulation of USP18 reduces tumor-infiltrating activated dendritic cells in extranodal diffuse large B cell lymphoma patients. PMID:34001679
Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells. PMID:34001596
Single cell RNA-seq analysis of the flexor digitorum brevis mouse myofibers. PMID:34001262
The fructose-1,6-bisphosphatase deficiency and the p.(Lys204ArgfsTer72) variant. PMID:33999094
Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1. PMID:33997693
LINC02257, an Enhancer RNA of Prognostic Value in Colon Adenocarcinoma, Correlates With Multi-Omics Immunotherapy-Related Analysis in 33 Cancers. PMID:33996902
Ferroptosis-Related Gene Signature Accurately Predicts Survival Outcomes in Patients With Clear-Cell Renal Cell Carcinoma. PMID:33996565
Network Analyses Predict Small RNAs That Might Modulate Gene Expression in the Testis and Epididymis of Bos indicus Bulls. PMID:33995471
Inborn disorders of the malate aspartate shuttle. PMID:33990986
G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis. PMID:33990686
HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1. PMID:33990627
Histone H3K9 butyrylation is regulated by dietary fat and stress via an Acyl-CoA dehydrogenase short chain-dependent mechanism. PMID:33989779
Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1. PMID:33986741
Targeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma. PMID:33986254
Novel Strategies to Address the Challenges in Top-Down Proteomics. PMID:33983025
Early onset epilepsy and sudden unexpected death in epilepsy with cardiac arrhythmia in mice carrying the early infantile epileptic encephalopathy 47 gain-of-function FHF1(FGF12) missense mutation. PMID:33982289
Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents. PMID:33981016
Ketamine disrupts naturalistic coding of working memory in primate lateral prefrontal cortex networks. PMID:33981008
Endocannabinoid signaling pathways: beyond CB1R and CB2R. PMID:33978927
Synthetic Biology: Emerging Concepts to Design and Advance Adeno-Associated Viral Vectors for Gene Therapy. PMID:33977059
Missense mutations in small muscle protein X-linked (SMPX) cause distal myopathy with protein inclusions. PMID:33974137
Omics community detection using multi-resolution clustering. PMID:33974004
hu.MAP 2.0: integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies. PMID:33973408
Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data. PMID:33972534
Knowledge bases and software support for variant interpretation in precision oncology. PMID:33971666
Validation of the functions and prognostic values of synapse-associated proteins in lower-grade glioma. PMID:33969375
One-Year Prospective Study of Plasma Biomarkers From CNS in Patients With Mild Traumatic Brain Injury. PMID:33967940
WNK1 is an assembly factor for the human ER membrane protein complex. PMID:33964204
Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa. PMID:33963188
Defining functional variants associated with Alzheimer's disease in the induced immune response. PMID:33959712
Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance. PMID:33953682
Mass Spectral Analysis of Synthetic Peptides: Implications in Proteomics. PMID:33953644
Ferret Interferon (IFN)-Inducible Transmembrane Proteins Are Upregulated by both IFN-α and Influenza Virus Infection. PMID:33952646
A Human Endogenous Bornavirus-Like Nucleoprotein Encodes a Mitochondrial Protein Associated with Cell Viability. PMID:33952640
Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy. PMID:33952630
Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer. PMID:33952262
A Review of Functional Characterization of Single Amino Acid Change Mutations in HNF Transcription Factors in MODY Pathogenesis. PMID:33950347
Down-regulation of microRNA-125b-2-3p is a risk factor for a poor prognosis in hepatocellular carcinoma. PMID:33949293
Establishment and verification of prognostic model for gastric cancer based on autophagy-related genes. PMID:33948361
Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence. PMID:33947761
Glutathione S-Transferases in Cancer. PMID:33946704
Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells. PMID:33946672
Structural Variants Selected during Yak Domestication Inferred from Long-Read Whole-Genome Sequencing. PMID:33944937
Protein structure-based gene expression signatures. PMID:33941686
Cerebral organoids and their potential for studies of brain diseases in domestic animals. PMID:33941270
A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression. PMID:33937393
Identification of novel bladder sensory GPCRs. PMID:33932109
Mesothelin/CD3 half-life extended bispecific T-cell engager molecule shows specific tumor uptake and distributes to mesothelin and CD3 expressing tissues. PMID:33931466
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer. PMID:33931024
Second-Trimester Placental and Thyroid Hormones Are Associated With Cognitive Development From Ages 1 to 3 Years. PMID:33928202
Identification of SHMT2 as a Potential Prognostic Biomarker and Correlating with Immune Infiltrates in Lung Adenocarcinoma. PMID:33928169
Nanobodies for Medical Imaging: About Ready for Prime Time? PMID:33925941
Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness. PMID:33924911
Muscle Glycogen Phosphorylase and Its Functional Partners in Health and Disease. PMID:33924466
Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues. PMID:33923459
RNA-Binding Protein HuD as a Versatile Factor in Neuronal and Non-Neuronal Systems. PMID:33922479
Eps15 Homology Domain-Containing Protein 3 Hypermethylation as a Prognostic and Predictive Marker for Colorectal Cancer. PMID:33922189
Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer. PMID:33921749
Multiplexed In Situ Protein Profiling with High-Performance Cleavable Fluorescent Tyramide. PMID:33921211
The Leloir Cycle in Glioblastoma: Galactose Scavenging and Metabolic Remodeling. PMID:33920278
Ultramicronized Palmitoylethanolamide (um-PEA): A New Possible Adjuvant Treatment in COVID-19 patients. PMID:33917573
Functional Roles of SPINK1 in Cancers. PMID:33916984
A molecular single-cell lung atlas of lethal COVID-19. PMID:33915568
In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung. PMID:33915162
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids. PMID:33915081
A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases. PMID:33913706
Seven Glycolysis-Related Genes Predict the Prognosis of Patients With Pancreatic Cancer. PMID:33912561
Engineering Extracellular Vesicles to Target Pancreatic Tissue In Vivo. PMID:33912378
CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Acting in cis. PMID:33910952
Prognostic value of SH3PXD2B (Tks4) in human hepatocellular carcinoma: a combined multi-omics and experimental study. PMID:33906640
Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11. PMID:33901943
A coupled enzyme assay for detection of selenium-binding protein 1 (SELENBP1) methanethiol oxidase (MTO) activity in mature enterocytes. PMID:33901808
Identification of hub genes associated with obesity-induced hepatocellular carcinoma risk based on integrated bioinformatics analysis. PMID:33900477
Systemic analysis of the expression levels and prognosis of breast cancer-related cadherins. PMID:33899544
Sex-Specific Role for SLIT1 in Regulating Stress Susceptibility. PMID:33896623
Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli. PMID:33893305
The VRNetzer platform enables interactive network analysis in Virtual Reality. PMID:33893283
Pharmacological inhibition of USP30 activates tissue-specific mitophagy. PMID:33890401
Glutathione-related genetic polymorphisms are associated with mercury retention and nephrotoxicity in gold-mining settings of a Colombian population. PMID:33888803
A comprehensive characterization of the cell-free transcriptome reveals tissue- and subtype-specific biomarkers for cancer detection. PMID:33883548
Epigenome-wide association study of level and change in cognitive abilities from midlife through late life. PMID:33883019
Dual RNA Sequencing Meta-analysis in Plasmodium Infection Identifies Host-Parasite Interactions. PMID:33879496
Induced pluripotent stem cells from subjects with Lesch-Nyhan disease. PMID:33875724
The Association of Mitochondrial Copy Number With Sarcopenia in Adult Survivors of Childhood Cancer. PMID:33871611
Whole genome transcriptome analysis of the stomach resected in human vertical sleeve gastrectomy: cutting more than calories. PMID:33870723
Urea as a By-Product of Ammonia Metabolism Can Be a Potential Serum Biomarker of Hepatocellular Carcinoma. PMID:33869206
SLC39A8/Zinc Suppresses the Progression of Clear Cell Renal Cell Carcinoma. PMID:33869056
Identification of IFN-Induced Transmembrane Protein 1 With Prognostic Value in Pancreatic Cancer Using Network Module-Based Analysis. PMID:33869009
GPCards: An integrated database of genotype-phenotype correlations in human genetic diseases. PMID:33868597
Small Molecule Targeting of Oxysterol-Binding Protein (OSBP)-Related Protein 4 and OSBP Inhibits Ovarian Cancer Cell Proliferation in Monolayer and Spheroid Cell Models. PMID:33860198
Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets. PMID:33859189
Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery. PMID:33859163
HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy. PMID:33858848
A novel predicted ADP-ribosyltransferase-like family conserved in eukaryotic evolution. PMID:33854844
Familial wild-type gastrointestinal stromal tumour in association with germline truncating variants in both SDHA and PALB2. PMID:33854214
Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer. PMID:33854168
Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms. PMID:33852859
Growth Hormone Releasing Hormone Reduces Circulating Markers of Immune Activation in Parallel with Effects on Hepatic Immune Pathways in Individuals with HIV-infection and Nonalcoholic Fatty Liver Disease. PMID:33852720
The gut microbiome and arsenic-induced disease-iAs metabolism in mice. PMID:33852125
Y chromosome copy number variation and its effects on fertility and other health factors: a review. PMID:33850773
TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes. PMID:33849445
iNetModels 2.0: an interactive visualization and database of multi-omics data. PMID:33849075
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones. PMID:33846299
Evaluation and Refinement of Sample Preparation Methods for Extracellular Matrix Proteome Coverage. PMID:33845168
Identification of Stemness-Related Genes for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma by Integrated Bioinformatics Analysis. PMID:33842467
Neurology and the COVID-19 Pandemic: Gathering Data for an Informed Response. PMID:33842072
TIGIT-Fc as a Potential Therapeutic Agent for Fetomaternal Tolerance. PMID:33841433
Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs. PMID:33839157
The circulating soluble form of the CD40 costimulatory immune checkpoint receptor and liver metastasis risk in rectal cancer. PMID:33837301
Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective. PMID:33835398
Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain. PMID:33833410
L Antigen Family Member 3 Serves as a Prognostic Biomarker for the Clinical Outcome and Immune Infiltration in Skin Cutaneous Melanoma. PMID:33829062
Regulation of Synaptic Transmission and Plasticity by Protein Phosphatase 1. PMID:33827970
CAR-T Cell Therapy for Acute Myeloid Leukemia: Preclinical Rationale, Current Clinical Progress, and Barriers to Success. PMID:33826079
TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation. PMID:33823896
Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single cell analysis. PMID:33821282
Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression. PMID:33819739
Studies of the role of basophils in aspirin-exacerbated respiratory disease pathogenesis. PMID:33819512
The Effect of Sodium Glucose Cotransporter 2 Inhibitors From a Human Genetic Perspective. PMID:33815487
Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Agents. PMID:33815364
LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling. PMID:33815143
Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis. PMID:33812333
Ferroptosis, trophoblast lipotoxic damage, and adverse pregnancy outcome. PMID:33812183
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. PMID:33811184
Growth Arrest-Specific Factor 6 (GAS6) Is Increased in COVID-19 Patients and Predicts Clinical Outcome. PMID:33810394
Aminopeptidase Expression in Multiple Myeloma Associates with Disease Progression and Sensitivity to Melflufen. PMID:33810334
Structural Biology and Structure-Function Relationships of Membrane Proteins. PMID:33809831
Dimethyl Sulfoxide: Morphological, Histological, and Molecular View on Developing Chicken Liver. PMID:33809222
Large Scale Molecular Studies of Pituitary Neuroendocrine Tumors: Novel Markers, Mechanisms and Translational Perspectives. PMID:33808624
Negative Regulation of the Innate Immune Response through Proteasomal Degradation and Deubiquitination. PMID:33808506
CD5L as an Extracellular Vesicle-Derived Biomarker for Liquid Biopsy of Lung Cancer. PMID:33808296
Evaluation of Fast Molecular Detection of Lymph Node Metastases in Prostate Cancer Patients Using One-Step Nucleic Acid Amplification (OSNA). PMID:33807774
More Than Meets the Eye: Revisiting the Roles of Heat Shock Factor 4 in Health and Diseases. PMID:33807297
Quantitative Proteomics Analysis of Berberine-Treated Colon Cancer Cells Reveals Potential Therapy Targets. PMID:33806918
A Comparative in Silico Analysis of CD24's Prognostic Value in Human and Canine Prostate Cancer. PMID:33806857
Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the Interface between Metabolism and Cell Cycle: A Systematic Review. PMID:33806509
Identifying Molecular Signatures of Distinct Modes of Collective Migration in Response to the Microenvironment Using Three-Dimensional Breast Cancer Models. PMID:33804802
Endothelial Autocrine Signaling through CXCL12/CXCR4/FoxM1 Axis Contributes to Severe Pulmonary Arterial Hypertension. PMID:33804745
AtFAHD1a: A New Player Influencing Seed Longevity and Dormancy in Arabidopsis? PMID:33804275
Leptin Is Associated with Poor Clinical Outcomes and Promotes Clear Cell Renal Cell Carcinoma Progression. PMID:33804101
The Biological Significance of Targeting Acetylation-Mediated Gene Regulation for Designing New Mechanistic Tools and Potential Therapeutics. PMID:33803759
Combined De-Repression of Chemoresistance Associated Mitogen-Activated Protein Kinase 14 and Activating Transcription Factor 2 by Loss of microRNA-622 in Hepatocellular Carcinoma. PMID:33803354
Relevance of 2'-O-Methylation and Pseudouridylation for the Malignant Melanoma. PMID:33803145
Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era. PMID:33802862
Proof-of-Concept: Antisense Oligonucleotide Mediated Skipping of Fibrillin-1 Exon 52. PMID:33801742
The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases. PMID:33800554
Leptin and Cancer: Updated Functional Roles in Carcinogenesis, Therapeutic Niches, and Developments. PMID:33799880
β3-Adrenoreceptors as ROS Balancer in Hematopoietic Stem Cell Transplantation. PMID:33799536
Oncolytic Virus Therapy Alters the Secretome of Targeted Glioblastoma Cells. PMID:33799381
SARS-CoV-2 as Enteric Virus in Wastewater: Which Risk on the Environment and Human Behavior? PMID:33795937
The Functional Classification of ORF8 in SARS-CoV-2 Replication, Immune Evasion, and Viral Pathogenesis Inferred through Phylogenetic Profiling. PMID:33795929
A Critical Role of Peptidylprolyl Isomerase A Pseudogene 22/microRNA-197-3p/Peptidylprolyl Isomerase A Axis in Hepatocellular Carcinoma. PMID:33790943
Adaptive gene misregulation. PMID:33789344
Consensus Transcriptional Landscape of Human End-Stage Heart Failure. PMID:33787284
Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B-related hepatocellular carcinoma. PMID:33783990
Gastrointestinal Symptoms Predict the Outcomes From COVID-19 Infection. PMID:33780223
Atypical focal segmental glomerulosclerosis associated with a new PODXL nonsense variant. PMID:33780168
Distinct genomic features across cytolytic subgroups in skin melanoma. PMID:33779796
USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization. PMID:33777217
The Molecular Function of PURA and Its Implications in Neurological Diseases. PMID:33777106
Beyond standard pipeline and p < 0.05 in pathway enrichment analyses. PMID:33774420
Degradation from the outside in: Targeting extracellular and membrane proteins for degradation through the endolysosomal pathway. PMID:33770486
Loss-of-Function Variants in the SYNPO2L Gene Are Associated With Atrial Fibrillation. PMID:33768119
Overexpression of NPTX2 Promotes Malignant Phenotype of Epithelial Ovarian Carcinoma via IL6-JAK2/STAT3 Signaling Pathway Under Hypoxia. PMID:33768003
Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19. PMID:33767597
Denoising large-scale biological data using network filters. PMID:33765911
Effect of small molecule eRF3 degraders on premature termination codon readthrough. PMID:33764477
Down-regulation of solute carrier family 10 member 1 is associated with early recurrence and poorer prognosis of hepatocellular carcinoma. PMID:33763615
Critical role of mass spectrometry proteomics in tear biomarker discovery for multifactorial ocular diseases (Review). PMID:33760148
Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment. PMID:33758004
A single-cell survey of the human glomerulonephritis. PMID:33754492
GPRC5A: An emerging prognostic biomarker for predicting malignancy of Pancreatic Cancer based on bioinformatics analysis. PMID:33753999
Comprehensive analysis of ceRNA networks reveals prognostic lncRNAs related to immune infiltration in colorectal cancer. PMID:33750326
Integrated intra- and intercellular signaling knowledge for multicellular omics analysis. PMID:33749993
A Natural Xenogeneic Endometrial Extracellular Matrix Hydrogel Toward Improving Current Human in vitro Models and Future in vivo Applications. PMID:33748086
Comprehensive Analysis of the Immune and Prognostic Implication of COL6A6 in Lung Adenocarcinoma. PMID:33747955
Identification of Five Glycolysis-Related Gene Signature and Risk Score Model for Colorectal Cancer. PMID:33747908
Identification of MEG8/miR-378d/SOBP axis as a novel regulatory network and associated with immune infiltrates in ovarian carcinoma by integrated bioinformatics analysis. PMID:33742531
HDL biodistribution and brain receptors in zebrafish, using HDLs as vectors for targeting endothelial cells and neural progenitors. PMID:33742021
Nidogen-1 expression is associated with overall survival and temozolomide sensitivity in low-grade glioma patients. PMID:33735110
Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1. PMID:33732413
Kidney involvement in coronavirus-associated diseases (Review). PMID:33732334
Molecular clues in the regulation of mini-puberty involve neuronal DNA binding transcription factor NHLH2. PMID:33731013
Tumor levels of the mediators of ErbB2-driven anoikis resistance correlate with breast cancer relapse in patients receiving trastuzumab-based therapies. PMID:33728523
NG2/CSPG4, CD146/MCAM and VAP1/AOC3 are regulated by myocardin-related transcription factors in smooth muscle cells. PMID:33727640
Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen. PMID:33727531
Multi-omics approaches for revealing the complexity of cardiovascular disease. PMID:33725119
Circulating proteins associated with allergy development in infants-an exploratory analysis. PMID:33722194
Quantitative Proteomic Profiling Identifies a Potential Novel Chaperone Marker in Resistant Breast Cancer. PMID:33718123
PD-L1 siRNA Theranostics With a Dextran Nanoparticle Highlights the Importance of Nanoparticle Delivery for Effective Tumor PD-L1 Downregulation. PMID:33718115
Exploration of the Prognostic and Immunotherapeutic Value of B and T Lymphocyte Attenuator in Skin Cutaneous Melanoma. PMID:33718105
Do Molecular Profiles of Primary Versus Metastatic Radioiodine Refractory Differentiated Thyroid Cancer Differ? PMID:33716974
CDH6-activated αIIbβ3 crosstalks with α2β1 to trigger cellular adhesion and invasion in metastatic ovarian and renal cancers. PMID:33715292
Endometrial laminin subunit beta-3 expression associates with reproductive outcome in patients with repeated implantation failure. PMID:33715134
Human OVCA2 and its homolog FSH3-induced apoptosis in Saccharomyces cerevisiae. PMID:33715035
The rise and fall of anandamide: processes that control synthesis, degradation, and storage. PMID:33713246
Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood-brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study. PMID:33712077
Identification of four key prognostic genes and three potential drugs in human papillomavirus negative head and neck squamous cell carcinoma. PMID:33712015
Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI. PMID:33711514
Integrated analysis of RNA-binding proteins in thyroid cancer. PMID:33711033
Proteomic profiling of the interface between the stomach wall and the pancreas in dystrophinopathy. PMID:33709651
Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1. PMID:33709453
Structural Mechanism of Cooperative Regulation of Calcium-Sensing Receptor-Mediated Cellular Signaling. PMID:33709045
LSD1 Promotes Prostate Cancer Cell Survival by Destabilizing FBXW7 at Post-Translational Level. PMID:33708617
Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing. PMID:33708225
Identification of TRIM56 as a Potential Biomarker for Lung Adenocarcinoma. PMID:33707970
Joint analysis of expression levels and histological images identifies genes associated with tissue morphology. PMID:33707455
Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death. PMID:33704068
Calcium-binding and coiled-coil domain 2 promotes the proliferation and suppresses apoptosis of prostate cancer cells. PMID:33692836
Macrophage M2 Co-expression Factors Correlate With the Immune Microenvironment and Predict Outcome of Renal Clear Cell Carcinoma. PMID:33692827
Prosaposin mediates inflammation in atherosclerosis. PMID:33692130
Discovery and validation of PZP as a novel serum biomarker for screening lung adenocarcinoma in type 2 diabetes mellitus patients. PMID:33691685
Gene alteration in zebrafish exposed to a mixture of substances of abuse. PMID:33689951
Enrichment of Placental Trophoblast Cells from Clinical Cervical Samples Using Differences in Surface Adhesion on an Inclined Plane. PMID:33686620
RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors. PMID:33684443
Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. PMID:33683200
CD96 Correlates With Immune Infiltration and Impacts Patient Prognosis: A Pan-Cancer Analysis. PMID:33680972
Exploring the Stress Impact in the Paternal Germ Cells Epigenome: Can Catecholamines Induce Epigenetic Reprogramming? PMID:33679612
Genetic and Epigenetic Regulation of Organic Cation Transporters. PMID:33674913
Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma. PMID:33674603
TRIM Proteins in Colorectal Cancer: TRIM8 as a Promising Therapeutic Target in Chemo Resistance. PMID:33673719
Proteomic Analysis of Low-Grade, Early-Stage Endometrial Carcinoma Reveals New Dysregulated Pathways Associated with Cell Death and Cell Signaling. PMID:33672863
Differential Effects of STCH and Stress-Inducible Hsp70 on the Stability and Maturation of NKCC2. PMID:33672238
Serum Free Amino Acid Profiling in Differential Diagnosis of Ovarian Tumors-A Comparative Study with Review of the Literature. PMID:33672144
Membrane Protein Stabilization Strategies for Structural and Functional Studies. PMID:33671740
Renal Proximal Tubule Cell Cannabinoid-1 Receptor Regulates Bone Remodeling and Mass via a Kidney-to-Bone Axis. PMID:33671138
Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics. PMID:33670680
CAR-T Therapy, the End of a Chapter or the Beginning of a New One? PMID:33670515
Knowledge-Guided "Community Network" Analysis Reveals the Functional Modules and Candidate Targets in Non-Small-Cell Lung Cancer. PMID:33669233
Association between Sour Taste SNP KCNJ2-rs236514, Diet Quality and Mild Cognitive Impairment in an Elderly Cohort. PMID:33668367
Zinc Finger Protein CTCF Regulates Extracellular Matrix (ECM)-Related Gene Expression Associated With the Wnt Signaling Pathway in Gastric Cancer. PMID:33665169
The cancer cell secretome drives cooperative manipulation of the tumour microenvironment to accelerate tumourigenesis. PMID:33659922
Balance between macrophage migration inhibitory factor and sCD74 predicts outcome in patients with acute decompensation of cirrhosis. PMID:33659891
The Changes of Leukocytes in Brain and Blood After Intracerebral Hemorrhage. PMID:33659003
Ablation of CRBN induces loss of type I collagen and SCH in mouse skin by fibroblast senescence via the p38 MAPK pathway. PMID:33658395
Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity. PMID:33658356
Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV). PMID:33657166
Differential proteomic analysis of children infected with respiratory syncytial virus. PMID:33656056
Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds. PMID:33653397
A machine learning-based gene signature of response to the novel alkylating agent LP-184 distinguishes its potential tumor indications. PMID:33653269
Biological impact of mutually exclusive exon switching. PMID:33651795
The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2. PMID:33649974
Combination of miR‑143 and miR‑506 reduces lung and pancreatic cancer cell growth through the downregulation of cyclin‑dependent kinases. PMID:33649787
Synthesis and Initial Characterization of a Selective, Pseudo-irreversible Inhibitor of Human Butyrylcholinesterase as PET Tracer. PMID:33645891
Phenotypic and protein localization heterogeneity associated with AHDC1 pathogenic protein-truncating alleles in Xia-Gibbs syndrome. PMID:33644933
Retinoic Acid Induced Protein 14 (Rai14) is dispensable for mouse spermatogenesis. PMID:33643708
Potential Molecular Mechanism of TNF Superfamily-Related Genes in Glioblastoma Multiforme Based on Transcriptome and Epigenome. PMID:33643183
DbStRiPs: Database of structural repeats in proteins. PMID:33641184
Pregnancy Serum DLK1 Concentrations Are Associated With Indices of Insulin Resistance and Secretion. PMID:33640968
Reflections on the HUPO Human Proteome Project, the Flagship Project of the Human Proteome Organization, at 10 Years. PMID:33640492
Pro-Tumoral Functions of Autophagy Receptors in the Modulation of Cancer Progression. PMID:33634029
Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner. PMID:33633567
Role of the V1G1 subunit of V-ATPase in breast cancer cell migration. PMID:33633298
Novel method for screening functional antibody with comprehensive analysis of its immunoliposome. PMID:33633189
Mining Unknown Porcine Protein Isoforms by Tissue-based Map of Proteome Enhances Pig Genome Annotation. PMID:33631433
SPA: A Quantitation Strategy for MS Data in Patient-derived Xenograft Models. PMID:33631430
Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis. PMID:33630577
A Novel Missense Variant in the Gene PPP2R5D Causes a Rare Neurodevelopmental Disorder with Increased Phenotype. PMID:33628804
Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants. PMID:33627123
Comprehensive Analysis of Gene Expression Changes and Validation in Hepatocellular Carcinoma. PMID:33623390
The novel roles of virus infection-associated gene CDKN1A in chemoresistance and immune infiltration of glioblastoma. PMID:33621203
Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. PMID:33618763
Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2. PMID:33609069
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. PMID:33606986
Processing and Analysis of RNA-seq Data from Public Resources. PMID:33606253
Applications of Community Detection Algorithms to Large Biological Datasets. PMID:33606252
Bisphenol S and Epidermal Growth Factor Receptor Signaling in Human Placental Cytotrophoblasts. PMID:33605785
Traptamer screening: a new functional genomics approach to study virus entry and other cellular processes. PMID:33604985
Discovering pathways in benign prostate hyperplasia: A functional genomics pilot study. PMID:33603850
Tenascin-W: Discovery, Evolution, and Future Prospects. PMID:33603752
PATZ1 (MAZR) Co-occupies Genomic Sites With p53 and Inhibits Liver Cancer Cell Proliferation via Regulating p27. PMID:33598459
Analysis of recurrently protected genomic regions in cell-free DNA found in urine. PMID:33597261
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity. PMID:33594203
Evidence for specificity of polygenic contributions to attainment in English, maths and science during adolescence. PMID:33594131
Genetic and epigenetic factors associated with increased severity of Covid-19. PMID:33590936
Epitope mimicry analysis of SARS-COV-2 surface proteins and human lung proteins. PMID:33588349
Highly Sensitive and Multiplexed Protein Imaging With Cleavable Fluorescent Tyramide Reveals Human Neuronal Heterogeneity. PMID:33585449
Construction of Bone Metastasis-Specific Regulation Network Based on Prognostic Stemness-Related Signatures in Breast Invasive Carcinoma. PMID:33585235
The Peptide Vaccine of the Future. PMID:33583769
Immune cell - produced ROS and their impact on tumor growth and metastasis. PMID:33583736
Subtype-dependent regulation of Gβγ signalling. PMID:33582184
Predicted 'wiring landscape' of Ras-effector interactions in 29 human tissues. PMID:33580066
DNA Mismatch Repair and its Role in Huntington's Disease. PMID:33579865
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome. PMID:33579698
Factorial study of the RNA-seq computational workflow identifies biases as technical gene signatures. PMID:33575596
Global variability analysis of mRNA and protein concentrations across and within human tissues. PMID:33575562
Identification of Three Autophagy-Related Long Non-Coding RNAs as a Novel Head and Neck Squamous Cell Carcinoma Prognostic Signature. PMID:33575215
Key genes in youth colorectal cancer based on data mining and verification by reverse transcription-quantitative PCR. PMID:33574933
Molecular Characterization of Paralichthys olivaceus MAF1 and Its Potential Role as an Anti-Viral Hemorrhagic Septicaemia Virus Factor in Hirame Natural Embryo Cells. PMID:33572970
Human Lectins, Their Carbohydrate Affinities and Where to Find Them. PMID:33572889
SWATH-MS Based Proteomic Profiling of Prostate Cancer Cells Reveals Adaptive Molecular Mechanisms in Response to Anti-Androgen Therapy. PMID:33572476
Glycine Cleavage System H Protein Is Essential for Embryonic Viability, Implying Additional Function Beyond the Glycine Cleavage System. PMID:33569080
LincRNA-immunity landscape analysis identifies EPIC1 as a regulator of tumor immune evasion and immunotherapy resistance. PMID:33568470
Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration. PMID:33567288
ACE2 Is a Prognostic Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma: Implication for COVID-19. PMID:33564310
Classification of node-positive melanomas into prognostic subgroups using keratin, immune, and melanogenesis expression patterns. PMID:33564068
ComHub: Community predictions of hubs in gene regulatory networks. PMID:33563211
Advances in Membranous Nephropathy. PMID:33562791
Urothelium-Specific Deletion of Connexin43 in the Mouse Urinary Bladder Alters Distension-Induced ATP Release and Voiding Behavior. PMID:33562445
Target Score-A Proteomics Data Selection Tool Applied to Esophageal Cancer Identifies GLUT1-Sialyl Tn Glycoforms as Biomarkers of Cancer Aggressiveness. PMID:33562270
Ergothioneine, recent developments. PMID:33558182
Role of the HSP70 Co-Chaperone SIL1 in Health and Disease. PMID:33557244
Targeting the Hippo Pathway in Prostate Cancer: What's New? PMID:33557087
A unique esophageal extracellular matrix proteome alters normal fibroblast function in severe eosinophilic esophagitis. PMID:33556465
Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens. PMID:33554062
Caveolin-1 promotes radioresistance via IRGM-regulated autophagy in lung cancer. PMID:33553340
Up-regulation of L Antigen Family Member 3 Associates With Aggressive Progression of Breast Cancer. PMID:33552947
Engineered Tools to Study Intercellular Communication. PMID:33552865
The clinical significance of glutathione peroxidase 2 in glioblastoma multiforme. PMID:33552592
Construction and Analysis of a ceRNA Network in Cardiac Fibroblast During Fibrosis Based on in vivo and in vitro Data. PMID:33552116
Establishment and validation of an RNA binding protein-associated prognostic model for ovarian cancer. PMID:33550985
RHO GTPases: from new partners to complex immune syndromes. PMID:33547421
Transcriptome comparisons of in vitro intestinal epithelia grown under static and microfluidic gut-on-chip conditions with in vivo human epithelia. PMID:33547413
Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles. PMID:33547159
Potential APOBEC-mediated RNA editing of the genomes of SARS-CoV-2 and other coronaviruses and its impact on their longer term evolution. PMID:33545556
Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types. PMID:33543003
Membrane Interactome of a Recombinant Fragment of Human Surfactant Protein D Reveals GRP78 as a Novel Binding Partner in PC3, a Metastatic Prostate Cancer Cell Line. PMID:33542717
Does C-C Motif Chemokine Ligand 2 (CCL2) Link Obesity to a Pro-Inflammatory State? PMID:33540898
Creatine Metabolism in Female Reproduction, Pregnancy and Newborn Health. PMID:33540766
Making Sense of Intracellular Nucleic Acid Sensing in Type I Interferon Activation in Sjögren's Syndrome. PMID:33540529
Prognostic impact of elevated fatty acid-binding protein 1 in patients with heart failure. PMID:33539661
Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors. PMID:33538575
Vascular Adhesion Protein-1 Determines the Cellular Properties of Endometrial Pericytes. PMID:33537312
Transient receptor potential channels in sensory mechanisms of the lower urinary tract. PMID:33536636
Candidate Biomarkers for Specific Intraoperative Near-Infrared Imaging of Soft Tissue Sarcomas: A Systematic Review. PMID:33535618
Position statement for a pragmatic approach to immunotherapeutics in patients with inflammatory skin diseases during the coronavirus disease 2019 pandemic and beyond. PMID:33533553
Novel coronavirus (COVID-19) and its potential G.I. manifestation: A review. PMID:33532381
Identification of colorectal cancer-associated macrophage biomarkers by integrated bioinformatic analysis. PMID:33532018
Pathophysiologic mechanisms of cerebral endotheliopathy and stroke due to Sars-CoV-2. PMID:33530831
Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding. PMID:33529594
A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. PMID:33526449
DeCompress: tissue compartment deconvolution of targeted mRNA expression panels using compressed sensing. PMID:33524140
S100A8/S100A9 cytokine acts as a transcriptional coactivator during breast cellular transformation. PMID:33523865
Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation length. PMID:33522483
Analysis of Human Faecal Host Proteins: Responsiveness to 10-Week Dietary Intervention Modifying Dietary Protein Intake in Elderly Males. PMID:33521034
ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Infection in COVID-19 Patients. PMID:33521006
Evolutionarily Conserved Long Non-coding RNA Regulates Gene Expression in Cytokine Storm During COVID-19. PMID:33520952
Xia-Gibbs Syndrome: A Review of Literature. PMID:33520547
Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population. PMID:33517564
Verifying explainability of a deep learning tissue classifier trained on RNA-seq data. PMID:33514769
A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis. PMID:33513212
Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci. PMID:33508947
Functional characterization of the dural sinuses as a neuroimmune interface. PMID:33508229
Peroxisomal Metabolite and Cofactor Transport in Humans. PMID:33505966
circRNA circ_102049 Implicates in Pancreatic Ductal Adenocarcinoma Progression through Activating CD80 by Targeting miR-455-3p. PMID:33505218
Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility. PMID:33504897
Multi-organ proteomic landscape of COVID-19 autopsies. PMID:33503446
Association of single-nucleotide polymorphisms in the ESR2 and FSHR genes with poor ovarian response in infertile Jordanian women. PMID:33503363
Comprehensive analysis of PLOD family members in low-grade gliomas using bioinformatics methods. PMID:33503035
Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine. PMID:33501433
Monocytes carrying GFAP detect glioma, brain metastasis and ischaemic stroke, and predict glioblastoma survival. PMID:33501422
HPAStainR: a Bioconductor and Shiny app to query protein expression patterns in the Human Protein Atlas. PMID:33500778
Dual Antimicrobial and Antiproliferative Activity of TcPaSK Peptide Derived from a Tribolium castaneum Insect Defensin. PMID:33499187
Colorectal cancer and COVID-19: Do we need to raise awareness and vigilance? PMID:33498093
Exogenous exposure to dihydroxyacetone mimics high fructose induced oxidative stress and mitochondrial dysfunction. PMID:33496975
Identification of therapeutic targets and prognostic biomarkers from the hnRNP family in invasive breast carcinoma. PMID:33495416
Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging. PMID:33495349
Kidney injury molecule-1 is a potential receptor for SARS-CoV-2. PMID:33493263
Expression and prognostic analyses of SCAMPs in pancreatic adenocarcinoma. PMID:33493138
A new view of macula densa cell microanatomy. PMID:33491562
Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly. PMID:33491286
Olfactory marker protein interacts with adenosine nucleotide derivatives. PMID:33490644
Integrative Expression and Prognosis Analysis of DHX37 in Human Cancers by Data Mining. PMID:33490273
Data-Driven Discovery of Molecular Targets for Antibody-Drug Conjugates in Cancer Treatment. PMID:33490264
Transcriptomic and Network Analysis of Minor Salivary Glands of Patients With Primary Sjögren's Syndrome. PMID:33488608
Growth Hormone and Neuronal Hemoglobin in the Brain-Roles in Neuroprotection and Neurodegenerative Diseases. PMID:33488521
Update of genetic variants in CEP120 and CC2D2A-With an emphasis on genotype-phenotype correlations, tissue specific transcripts and exploring mutation specific exon skipping therapies. PMID:33486889
De-coding genetic risk variants in type 1 diabetes. PMID:33483996
Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model. PMID:33483609
Urinary proteome profiling for stratifying patients with familial Parkinson's disease. PMID:33481347
Membranous nephropathy: current understanding of various causes in light of new target antigens. PMID:33480620
Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases. PMID:33479664
Study of the active ingredients and mechanism of Sparganii rhizoma in gastric cancer based on HPLC-Q-TOF-MS/MS and network pharmacology. PMID:33479376
Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma. PMID:33479234
Developmental cell programs are co-opted in inflammatory skin disease. PMID:33479125
Proteomics analysis of a human brain sample from a mucolipidosis type IV patient reveals pathophysiological pathways. PMID:33478506
Suprabasin-A Review. PMID:33477529
Diet and PPARG2 Pro12Ala Polymorphism Interactions in Relation to Cancer Risk: A Systematic Review. PMID:33477496
The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk. PMID:33476202
Targeting 5-HT2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling After Myocardial Infarction. PMID:33474971
Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate. PMID:33473133
Cellinker: a platform of ligand-receptor interactions for intercellular communication analysis. PMID:33471060
Terminal Deoxynucleotidyl Transferase Commonly Expresses in Germ Cell Tumors: Evaluation on a Large Series from Multiple Centers. PMID:33469349
Prognostic role of PHYH for overall survival (OS) in clear cell renal cell carcinoma (ccRCC). PMID:33468235
Functional Evaluation of a Rare Variant c.516G>C (p.Trp172Cys) in the GJB2 (Connexin 26) Gene Associated with Nonsyndromic Hearing Loss. PMID:33466560
Calcium-Dependent Translocation of S100B Is Facilitated by Neurocalcin Delta. PMID:33466232
Identification of potential biomarkers of peripheral blood mononuclear cell in hepatocellular carcinoma using bioinformatic analysis: A protocol for systematic review and meta-analysis. PMID:33466191
Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach. PMID:33462259
Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model. PMID:33456582
Atrial fibrillation rhythm is associated with marked changes in metabolic and myofibrillar protein expression in left atrial appendage. PMID:33454842
Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation. PMID:33453420
Androglobin gene expression patterns and FOXJ1-dependent regulation indicate its functional association with ciliogenesis. PMID:33453283
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection. PMID:33452205
The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases? PMID:33451033
Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations. PMID:33450391
GPER1 is required to protect fetal health from maternal inflammation. PMID:33446553
CARD8 and IL1B Polymorphisms Influence MRI Brain Patterns in Newborns with Hypoxic-Ischemic Encephalopathy Treated with Hypothermia. PMID:33445495
Donor genetic variants as risk factors for thrombosis after liver transplantation: A genome-wide association study. PMID:33445220
Increased expression of CELSR3 indicates a poor prognostic factor for Prostate Cancer. PMID:33442409
Human leukocyte antigen class II quantification by targeted mass spectrometry in dendritic-like cell lines and monocyte-derived dendritic cells. PMID:33441579
Accurate and efficient detection of gene fusions from RNA sequencing data. PMID:33441414
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients. PMID:33441124
Expansion of NEUROD2 phenotypes to include developmental delay without seizures. PMID:33438828
Longitudinal saliva omics responses to immune perturbation: a case study. PMID:33436912
Cytoplasmic short linear motifs in ACE2 and integrin β3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy. PMID:33436498
Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications. PMID:33436497
CHD2-Related CNS Pathologies. PMID:33435571
GPR55 Receptor Activation by the N-Acyl Dopamine Family Lipids Induces Apoptosis in Cancer Cells via the Nitric Oxide Synthase (nNOS) Over-Stimulation. PMID:33435517
Of numbers and movement - understanding transcription factor pathogenesis by advanced microscopy. PMID:33433399
The secretome mouse provides a genetic platform to delineate tissue-specific in vivo secretion. PMID:33431665
Experimental Models to Study COVID-19 Effect in Stem Cells. PMID:33430424
Combined RNA/tissue profiling identifies novel Cancer/testis genes. PMID:33426787
Variants in PPP2R2B and IGF2BP3 are associated with higher tau deposition. PMID:33426524
Alpha2-Antiplasmin: The Devil You Don't Know in Cerebrovascular and Cardiovascular Disease. PMID:33426005
In Search of Zonation Markers to Identify Liver Functional Disorders. PMID:33425221
Mechanistic Modeling of Gene Regulation and Metabolism Identifies Potential Targets for Hepatocellular Carcinoma. PMID:33424926
Comparative Analysis of Dorsal Root, Nodose and Sympathetic Ganglia for the Development of New Analgesics. PMID:33424545
An "expressionistic" look at serrated precancerous colorectal lesions. PMID:33423702
Identification of key modules and hub genes in glioblastoma multiforme based on co-expression network analysis. PMID:33423377
Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum. PMID:33419470
TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway. PMID:33419081
Patient-Derived Organotypic Epithelial Rafts Model Phenotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis. PMID:33418959
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. PMID:33417831
KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway. PMID:33416175
Improved secretion of recombinant human IL-25 in HEK293 cells using a signal peptide-pro-peptide domain derived from Trypsin-1. PMID:33415569
ACOX2 is a prognostic marker and impedes the progression of hepatocellular carcinoma via PPARα pathway. PMID:33414412
Differential and spatial expression meta-analysis of genes identified in genome-wide association studies of depression. PMID:33414381
Sex-dependent differences in the secretome of human endothelial cells. PMID:33413676
MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility. PMID:33408244
Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome. PMID:33406800
Role of pattern recognition receptors and the microbiota in neurological disorders. PMID:33404072
Circulating MicroRNAs in Relation to Esophageal Adenocarcinoma Diagnosis and Survival. PMID:33403483
Oncogenic and tumor suppressor function of MEIS and associated factors. PMID:33402862
Broad Auto-Reactive IgM Responses Are Common In Critically Ill COVID-19 Patients. PMID:33398261
Hereditary Hearing Impairment with Cutaneous Abnormalities. PMID:33396879
Identifying Personalized Metabolic Signatures in Breast Cancer. PMID:33396819
TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue. PMID:33396509
Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1. PMID:33395526
Loss of LIMCH1 predicts poor prognosis in patients with surgically resected Lung Adenocarcinoma: A study based on Immunohistochemical Analysis and Bioinformatics. PMID:33391414
Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma. PMID:33390805
Bioinformatics Analyses of Potential miRNA-mRNA Regulatory Axis in HBV-related Hepatocellular Carcinoma. PMID:33390802
Evaluation of Male Fertility-Associated Loci in a European Population of Patients with Severe Spermatogenic Impairment. PMID:33383876
Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure. PMID:33382739
Promotion of vascular integrity in sepsis through modulation of bioactive adrenomedullin and dipeptidyl peptidase 3. PMID:33381880
Validation of CSN1S1 transcriptional expression, promoter methylation, and prognostic power in breast cancer using independent datasets. PMID:33381666
Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation. PMID:33381480
FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases. PMID:33381084
The Skin Interactome: A Holistic "Genome-Microbiome-Exposome" Approach to Understand and Modulate Skin Health and Aging. PMID:33380819
Understanding the unimodal distributions of cancer occurrence rates: it takes two factors for a cancer to occur. PMID:33377150
Protocol for the Bottom-Up Proteomic Analysis of Mouse Spleen. PMID:33377090
Secret3D Workflow for Secretome Analysis. PMID:33377056
Immunohistochemical Analysis of PGC-1α and ERRα Expression Reveals Their Clinical Significance in Human Ovarian Cancer. PMID:33376354
C-type Lectin CD209L/L-SIGN and CD209/DC-SIGN: Cell Adhesion Molecules Turned to Pathogen Recognition Receptors. PMID:33375175
Sorting Nexins in Protein Homeostasis. PMID:33374212
Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19. PMID:33373644
HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails. PMID:33372037
Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma. PMID:33365083
The Future of GDNF in Parkinson's Disease. PMID:33364933
Regulatory Roles of Tumor Necrosis Factor-α-Induced Protein 8 Like-Protein 2 in Inflammation, Immunity and Cancers: A Review. PMID:33364825
Malignancy and IFITM3: Friend or Foe? PMID:33364194
Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases. PMID:33363699
Severe Acute Respiratory Syndrome Coronavirus 2-Induced Neurological Complications. PMID:33363165
PD-L1 Is a Tumor Suppressor in Aggressive Endometrial Cancer Cells and Its Expression Is Regulated by miR-216a and lncRNA MEG3. PMID:33363153
Profiling of H3K27Ac Reveals the Influence of Asthma on the Epigenome of the Airway Epithelium. PMID:33362848
From miRNA Target Gene Network to miRNA Function: miR-375 Might Regulate Apoptosis and Actin Dynamics in the Heart Muscle via Rho-GTPases-Dependent Pathways. PMID:33352947
The Role of Connexin 43 in Lung Disease. PMID:33352732
The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells. PMID:33351855
Coronavirus genomes carry the signatures of their habitats. PMID:33351847
Attenuated CSF-1R signalling drives cerebrovascular pathology. PMID:33350588
Biological characteristics of aging in human acute myeloid leukemia cells: the possible importance of aldehyde dehydrogenase, the cytoskeleton and altered transcriptional regulation. PMID:33349623
Tumors Widely Express Hundreds of Embryonic Germline Genes. PMID:33348709
Chemical carcinogen-induced rat mammary carcinogenesis is a potential model of p21-activated kinase positive female breast cancer. PMID:33346690
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2. PMID:33344479
Smell and Taste in Severe CoViD-19: Self-Reported vs. Testing. PMID:33344476
Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer. PMID:33342045
Parameterization of Microsomal and Cytosolic Scaling Factors: Methodological and Biological Considerations for Scalar Derivation and Validation. PMID:33340340
Prognostic relevance of programmed cell death 1 ligand 2 (PDCD1LG2/PD-L2) in patients with advanced stage colon carcinoma treated with chemotherapy. PMID:33339860
The lncRNA Toolkit: Databases and In Silico Tools for lncRNA Analysis. PMID:33339309
GSK3α: An Important Paralog in Neurodegenerative Disorders and Cancer. PMID:33339170
Decreasing the Susceptibility of Malignant Cells to Infection Does Not Impact the Overall Efficacy of Myxoma Virus-Based Oncolytic Virotherapy. PMID:33335977
Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING? PMID:33335532
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. PMID:33333007
Systemic transcriptome comparison between early- And late-onset pre-eclampsia shows distinct pathology and novel biomarkers. PMID:33332660
Liver Disease and Coronavirus Disease 2019: From Pathogenesis to Clinical Care. PMID:33332624
Functional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming. PMID:33330447
Increased NFATC4 Correlates With Poor Prognosis of AML Through Recruiting Regulatory T Cells. PMID:33329712
Identification of Interleukin-9 Producing Immune Cells in Endometrial Carcinoma and Establishment of a Prognostic Nomogram. PMID:33329510
Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System. PMID:33328896
PKBβ/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors. PMID:33328589
IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates. PMID:33324675
Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms. PMID:33322668
Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction. PMID:33322162
Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2. PMID:33320095
Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling. PMID:33319173
Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. PMID:33318207
Expression of PAWR predicts prognosis of ovarian cancer. PMID:33317551
A bioinformatics analysis on the potential role of ACE2 in cardiac impairment of patients with coronavirus disease 2019. PMID:33313148
ATP13A3 is a major component of the enigmatic mammalian polyamine transport system. PMID:33310703
Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time. PMID:33307245
Systematic Comparison of Vesicular Targeting Signals Leads to the Development of Genetically Encoded Vesicular Fluorescent Zn2+ and pH Sensors. PMID:33305939
PathExt: a general framework for path-based mining of omics-integrated biological networks. PMID:33305329
Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture. PMID:33304744
Mass Spectral Analysis of Synthetic Peptides: Implications in Proteomics. PMID:33304200
Rho-GTPase pathways may differentiate treatment response to TNF-alpha and IL-17A inhibitors in psoriatic arthritis. PMID:33303908
Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro. PMID:33303781
A Multi-Strategy Sequencing Workflow in Inherited Retinal Dystrophies: Routine Diagnosis, Addressing Unsolved Cases and Candidate Genes Identification. PMID:33302505
Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke. PMID:33301355
Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma. PMID:33300568
Identification of SRSF10 as a regulator of SMN2 ISS-N1. PMID:33300159
Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin. PMID:33300026
Genetic Diversity of the Noncoding Control Region of the Novel Human Polyomaviruses. PMID:33297530
The complex role of prostaglandin E2-EP receptor signaling in wound healing. PMID:33296281
Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease. PMID:33294859
A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury. PMID:33294858
Prognostic and Predictive Value of a 15 Transcription Factors (TFs) Panel for Hepatocellular Carcinoma. PMID:33293862
SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling. PMID:33293473
Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development. PMID:33292279
Assessing immune infiltration and the tumor microenvironment for the diagnosis and prognosis of sarcoma. PMID:33292275
Network and Evolutionary Analysis of Human Epigenetic Regulators to Unravel Disease Associations. PMID:33291839
Prospects for Using Expression Patterns of Paramyxovirus Receptors as Biomarkers for Oncolytic Virotherapy. PMID:33291506
Proteomic Study Identifies Glycolytic and Inflammation Pathways Involved in Recurrent Otitis Media. PMID:33291465
Proteomic signatures of 16 major types of human cancer reveal universal and cancer-type-specific proteins for the identification of potential therapeutic targets. PMID:33287876
The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma. PMID:33287763
Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring-An Inactive Enzyme with Intact Substrate Binding. PMID:33287293
Overexpression of TPX2 predicts poor clinical outcome and is associated with immune infiltration in hepatic cell cancer. PMID:33285774
Clinical Correlates of the NR3C1 Gene Methylation at Various Stages of Psychosis. PMID:33284958
Options for COVID-19 Entry into Pulmonary Cells. PMID:33283173
Effect of EGLN1 Genetic Polymorphisms on Hemoglobin Concentration in Andean Highlanders. PMID:33282944
Machine Learning Based Network Analysis Determined Clinically Relevant miRNAs in Breast Cancer. PMID:33281885
Expression of ATP/GTP Binding Protein 1 Has Prognostic Value for the Clinical Outcomes in Non-Small Cell Lung Carcinoma. PMID:33276627
Complex genetic dependencies among growth and neurological phenotypes in healthy children: Towards deciphering developmental mechanisms. PMID:33270668
The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer. PMID:33270085
A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation. PMID:33268789
Human Cytomegalovirus Induces the Expression of the AMPKa2 Subunit to Drive Glycolytic Activation and Support Productive Viral Infection. PMID:33268515
Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types. PMID:33266506
Machine Learning Identifies Robust Matrisome Markers and Regulatory Mechanisms in Cancer. PMID:33266472
The ADAR Family in Amphioxus: RNA Editing and Conserved Orthologous Site Predictions. PMID:33265998
Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins. PMID:33263282
Acute appendicitis in four children with SARS-CoV-2 infection. PMID:33262930
Bioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium. PMID:33262348
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import. PMID:33262325
Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer. PMID:33262136
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study. PMID:33261667
Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium. PMID:33256374
The G-Protein Coupled Formyl Peptide Receptors and Their Role in the Progression of Digestive Tract Cancer. PMID:33251986
Spatial Proteomic Approach to Characterize Skeletal Muscle Myofibers. PMID:33251806
Identification of potential biomarkers for lung adenocarcinoma. PMID:33251353
Serum RNA Profiling in the 10-Years Period Prior to Diagnosis of Testicular Germ Cell Tumor. PMID:33251139
On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. PMID:33246953
Missense variants in the N-terminal domain of the A isoform of FHF2/FGF13 cause an X-linked developmental and epileptic encephalopathy. PMID:33245860
PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2). PMID:33245768
Molecular Basis of Cardiac and Vascular Injuries Associated With COVID-19. PMID:33240937
Multiple functions of TBCK protein in neurodevelopment disorders and tumors. PMID:33240423
Identifying transcriptomic correlates of histology using deep learning. PMID:33237966
COVID-19 endocrinopathy with hindsight from SARS. PMID:33236920
Skin tape stripping identifies gene transcript signature associated with allergic contact dermatitis. PMID:33236775
Review of COVID-19 and male genital tract. PMID:33236375
Proteomics analysis of serum small extracellular vesicles for the longitudinal study of a glioblastoma multiforme mouse model. PMID:33235327
Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network. PMID:33234678
SARS-CoV-2 attachment to host cells is possibly mediated via RGD-integrin interaction in a calcium-dependent manner and suggests pulmonary EDTA chelation therapy as a novel treatment for COVID 19. PMID:33232865
BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. PMID:33232675
Upregulation of KIF20A promotes tumor proliferation and invasion in renal clear cell carcinoma and is associated with adverse clinical outcome. PMID:33232285
Top-down proteomics: challenges, innovations, and applications in basic and clinical research. PMID:33232185
PINA 3.0: mining cancer interactome. PMID:33231689
Downstream Neighbor of SON (DONSON) Expression Is Enhanced in Phenotypically Aggressive Prostate Cancers. PMID:33228112
The value of a metabolic reprogramming-related gene signature for pancreatic adenocarcinoma prognosis prediction. PMID:33226369
Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-Mediated ARDS. PMID:33214479
Obesity Represses CYP2R1, the Vitamin D 25-Hydroxylase, in the Liver and Extrahepatic Tissues. PMID:33210060
Expression and role of nuclear receptor-interacting protein 1 (NRIP1) in stomach adenocarcinoma. PMID:33209873
Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota. PMID:33208821
Altered Tissue and Plasma Levels of Fibroblast Activation Protein-α (FAP) in Renal Tumours. PMID:33207686
Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva. PMID:33207190
The IMEx coronavirus interactome: an evolving map of Coronaviridae-host molecular interactions. PMID:33206959
The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer. PMID:33205077
Urinary glycoproteins associated with aggressive prostate cancer. PMID:33204318
Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling. PMID:33203841
Genetic Predictors of Severe Skin Toxicity in Patients with Stage III Colon Cancer Treated with Cetuximab: NCCTG N0147 (Alliance). PMID:33203692
Targeting the renin-angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges. PMID:33203679
The 40bp Indel Polymorphism rs150550023 in the MDM2 Promoter is Associated with Intriguing Shifts in Gene Expression in the p53-MDM2 Regulatory Hub. PMID:33202864
Combined liver-kidney transplantation for rare diseases. PMID:33200012
Identification of a New QTL Region on Mouse Chromosome 1 Responsible for Male Hypofertility: Phenotype Characterization and Candidate Genes. PMID:33198087
A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project. PMID:33197228
Colitis-induced IL11 promotes colon carcinogenesis. PMID:33196831
The Pursuit of COVID-19 Biomarkers: Putting the Spotlight on ACE2 and TMPRSS2 Regulatory Sequences. PMID:33195331
Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery. PMID:33195264
Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment. PMID:33194695
Integration of Online Omics-Data Resources for Cancer Research. PMID:33193699
TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019. PMID:33193689
Theoretical and in silico Analyses Reveal MYC as a Dynamic Network Biomarker in Colon and Rectal Cancer. PMID:33193630
Identification of Prognostic Markers in Cholangiocarcinoma Using Altered DNA Methylation and Gene Expression Profiles. PMID:33193605
Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology. PMID:33191914
Bioinformatics analysis reveals TSPAN1 as a candidate biomarker of progression and prognosis in pancreatic cancer. PMID:33188589
Prognostic roles of metabolic reprogramming-associated genes in patients with hepatocellular carcinoma. PMID:33188160
Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker. PMID:33187367
Systematic comparison and assessment of RNA-seq procedures for gene expression quantitative analysis. PMID:33184454
Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice. PMID:33184425
Role of miRNAs in Sigmoid Colon Cancer: A Search for Potential Biomarkers. PMID:33182525
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4. PMID:33182504
Influence of Lipoxygenase Inhibition on Glioblastoma Cell Biology. PMID:33182324
EZH2 is a negative prognostic biomarker associated with immunosuppression in hepatocellular carcinoma. PMID:33180829
Comprehensive mapping of the human cytokine gene regulatory network. PMID:33179750
Comprehensive bioinformatics analysis of the TP53 signaling pathway in Wilms' tumor. PMID:33178760
α2-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling. PMID:33178692
Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19. PMID:33177848
Targeting receptor complexes: a new dimension in drug discovery. PMID:33177699
Prognosis prediction model for conversion from mild cognitive impairment to Alzheimer's disease created by integrative analysis of multi-omics data. PMID:33172501
Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta. PMID:33171905
Microbubbles Cloaked with Hydrogels as Activatable Ultrasound Contrast Agents. PMID:33170637
Enhanced Validation of Antibodies Enables the Discovery of Missing Proteins. PMID:33170010
Synergy of melanin and vitamin-D may play a fundamental role in preventing SARS-CoV-2 infections and halt COVID-19 by inactivating furin protease. PMID:33169107
Deciphering cell-cell interactions and communication from gene expression. PMID:33168968
COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics. PMID:33166390
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities. PMID:33164751
CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A. PMID:33163493
The role of transcription factor caudal-related homeobox transcription factor 2 in colorectal cancer. PMID:33163374
Discovery, validation and sequencing of urinary peptides for diagnosis of liver fibrosis-A multicentre study. PMID:33160210
Genetic and epigenetic factors determining NAFLD risk. PMID:33160101
Cardiac and Vascular α1-Adrenoceptors in Congestive Heart Failure: A Systematic Review. PMID:33158106
The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma. PMID:33154775
Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin. PMID:33154365
Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A. PMID:33152346
Multi-kinase framework promotes proliferation and invasion of lung adenocarcinoma through activation of dynamin-related protein 1. PMID:33152171
LINC00968 can inhibit the progression of lung adenocarcinoma through the miR-21-5p/SMAD7 signal axis. PMID:33147570
The Human Protein Atlas-Spatial localization of the human proteome in health and disease. PMID:33146890
Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment. PMID:33146700
Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype. PMID:33142937
BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling. PMID:33142801
Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage. PMID:33140861
Functional module detection through integration of single-cell RNA sequencing data with protein-protein interaction networks. PMID:33138772
Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations. PMID:33138277
The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits. PMID:33137877
PlacentaCellEnrich: A tool to characterize gene sets using placenta cell-specific gene enrichment analysis. PMID:33137644
On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins. PMID:33136379
Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa. PMID:33133517
A Transcriptomics-Based Meta-Analysis Combined With Machine Learning Identifies a Secretory Biomarker Panel for Diagnosis of Pancreatic Adenocarcinoma. PMID:33133160
Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models. PMID:33131247
The Complexity and Dynamics of the Tissue Glycoproteome Associated With Prostate Cancer Progression. PMID:33127837
Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19. PMID:33123533
Prognosis Analysis and Validation of m6A Signature and Tumor Immune Microenvironment in Glioma. PMID:33123464
SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer. PMID:33122723
Screening and identification of key genes and pathways in metastatic uveal melanoma based on gene expression using bioinformatic analysis. PMID:33120861
Increased E2F2 predicts poor prognosis in patients with HCC based on TCGA data. PMID:33115417
Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma. PMID:33114768
CCL18 in the Progression of Cancer. PMID:33114763
The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease. PMID:33114658
Highly Multiplexed Single-Cell In Situ RNA and DNA Analysis by Consecutive Hybridization. PMID:33113917
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2. PMID:33112891
Genetic predisposition to neural crest-derived tumors: revisiting the role of KIF1B. PMID:33112832
WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer. PMID:33109540
An integrated autophagy-related gene signature predicts prognosis in human endometrial Cancer. PMID:33109128
O-Pair Search with MetaMorpheus for O-glycopeptide characterization. PMID:33106676
Activatable Zymography Probes Enable In Situ Localization of Protease Dysregulation in Cancer. PMID:33106334
Voltage-Gated Calcium Channels in Nonexcitable Tissues. PMID:33106102
Three-gene prognostic biomarkers for seminoma identified by weighted gene co-expression network analysis. PMID:33104706
Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma. PMID:33103995
Protein-driven mechanism of multiorgan damage in COVID-19. PMID:33103107
Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis. PMID:33102693
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition. PMID:33101674
Whole Genome Sequence Data Provides Novel Insights Into the Genetic Architecture of Meat Quality Traits in Beef. PMID:33101375
Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of human NHE3 regulating its expression and activity. PMID:33095475
Genome-Wide Co-Expression Distributions as a Metric to Prioritize Genes of Functional Importance. PMID:33092259
Neurobiological origins of individual differences in mathematical ability. PMID:33090992
Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers. PMID:33087697
PLA2G6 guards placental trophoblasts against ferroptotic injury. PMID:33087576
Differential gene regulatory pattern in the human brain from schizophrenia using transcriptomic-causal network. PMID:33087039
The COVID-19 Pandemic from a Human Genetic Perspective. PMID:33084340
Improved detection of tumor suppressor events in single-cell RNA-Seq data. PMID:33083012
Base editing: advances and therapeutic opportunities. PMID:33077937
PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. PMID:33077911
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands. PMID:33076281
Understand variability of COVID-19 through population and tissue variations in expression of SARS-CoV-2 host genes. PMID:33072849
Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney. PMID:33072769
ABC Exporters in Pathogenesis: Role of Synthetic Anti-Microbial Peptides. PMID:33068233
A high-stringency blueprint of the human proteome. PMID:33067450
Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patients. PMID:33061814
Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C. PMID:33060297
Use of patient derived urine renal epithelial cells to confirm pathogenicity of PKHD1 alleles. PMID:33059616
GNG13 Is a Potential Marker of the State of Health of Alzheimer's Disease Patients' Cerebellum. PMID:33057964
Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours? PMID:33057948
Application of small molecule FPR1 antagonists in the treatment of cancers. PMID:33057069
Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies. PMID:33053333
Non-permissive SARS-CoV-2 infection in human neurospheres. PMID:33052345
Protein-protein and protein-nucleic acid binding residues important for common and rare sequence variants in human. PMID:33050876
p38 MAPK Pathway in the Heart: New Insights in Health and Disease. PMID:33049962
Stearoyl-CoA desaturase 5 (SCD5), a Δ-9 fatty acyl desaturase in search of a function. PMID:33049404
CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia. PMID:33046866
INTEDE: interactome of drug-metabolizing enzymes. PMID:33045737
Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis. PMID:33045259
SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidney disease. PMID:33038424
Src Family Protein Kinase Controls the Fate of B Cells in Autoimmune Diseases. PMID:33037966
ATP-Binding and Hydrolysis in Inflammasome Activation. PMID:33036374
Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes in vitro. PMID:33034335
PRELP has prognostic value and regulates cell proliferation and migration in hepatocellular carcinoma. PMID:33033521
Acyl-CoA synthetases as regulators of brain phospholipid acyl-chain diversity. PMID:33031993
Molecular Pathways Linking Oxylipins to Nociception in Rats. PMID:33031942
Tissue distributions of antiviral drugs affect their capabilities of reducing viral loads in COVID-19 treatment. PMID:33031797
Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer. PMID:33030783
Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age. PMID:33029858
Cholesterol-Induced Phenotypic Modulation of Smooth Muscle Cells to Macrophage/Fibroblast-like Cells Is Driven by an Unfolded Protein Response. PMID:33028096
Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis. PMID:33025553
MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis. PMID:33025009
Computational assessment of MCM2 transcriptional expression and identification of the prognostic biomarker for human breast cancer. PMID:33024849
A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer. PMID:33024794
Benchmarking evolutionary tinkering underlying human-viral molecular mimicry shows multiple host pulmonary-arterial peptides mimicked by SARS-CoV-2. PMID:33024578
The Glycoprotease CpaA Secreted by Medically Relevant Acinetobacter Species Targets Multiple O-Linked Host Glycoproteins. PMID:33024038
Modeling tissue-relevant Caenorhabditis elegans metabolism at network, pathway, reaction, and metabolite levels. PMID:33022146
An analysis of tissue-specific alternative splicing at the protein level. PMID:33017396
G-Quadruplex Helicase DHX36/G4R1 Engages Nuclear Lamina Proteins in Quiescent Breast Cancer Cells. PMID:33015511
Comprehensive Analysis of the Expression, Relationship to Immune Infiltration and Prognosis of TIM-1 in Cancer. PMID:33014768
COVID-19: Proposing a Ketone-Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm. PMID:33014275
Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases. PMID:33014146
Identification of a Novel Immune-Related Prognostic Biomarker and Small-Molecule Drugs in Clear Cell Renal Cell Carcinoma (ccRCC) by a Merged Microarray-Acquired Dataset and TCGA Database. PMID:33014010
Causal Effects of Genetically Determined Metabolites on Risk of Polycystic Ovary Syndrome: A Mendelian Randomization Study. PMID:33013699
Functions of p38 MAP Kinases in the Central Nervous System. PMID:33013322
Prognostic Score-based Clinical Factors and Metabolism-related Biomarkers for Predicting the Progression of Hepatocellular Carcinoma. PMID:33013158
Cancer diagnostics based on plasma protein biomarkers: hard times but great expectations. PMID:33012111
COVID-19 and multiorgan failure: A narrative review on potential mechanisms. PMID:33011887
Identification of prognostic biomarkers and correlations with immune infiltrates among cGAS-STING in hepatocellular carcinoma. PMID:33006365
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. PMID:33004675
The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process. PMID:33003328
Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19. PMID:33000221
High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner. PMID:32999402
Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19. PMID:32998512
Renin Angiotensin System, COVID-19 and Male Fertility: Any Risk for Conceiving? PMID:32998451
Stable gene expression for normalisation and single-sample scoring. PMID:32997146
The authors reply: Comment on "The expression landscape of cachexia-inducing factors in human cancers" by Freire et al. PMID:32996709
Extracellular vesicles in patients in the acute phase of psychosis and after clinical improvement: an explorative study. PMID:32995075
Selenium and selenoproteins in viral infection with potential relevance to COVID-19. PMID:32992282
The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion. PMID:32989016
8p11.23 Amplification in Breast Cancer: Molecular Characteristics, Prognosis and Targeted Therapy. PMID:32987805
Expanded Chinese hamster organ and cell line proteomics profiling reveals tissue-specific functionalities. PMID:32985598
Cell-Type-Specific Proteogenomic Signal Diffusion for Integrating Multi-Omics Data Predicts Novel Schizophrenia Risk Genes. PMID:32984858
The spectrum of biochemical alterations associated with organ dysfunction and inflammatory status and their association with disease outcomes in severe COVID-19: A longitudinal cohort and time-series design study. PMID:32984786
Quantitative systems pharmacology and the personalized drug-microbiota-diet axis. PMID:32984662
The Construction of Bone Metastasis-Specific Prognostic Model and Co-expressed Network of Alternative Splicing in Breast Cancer. PMID:32984314
Identification of Clinically Significant Prostate Cancer by Combined PCA3 and AMACR mRNA Detection in Urine Samples. PMID:32984088
Complement C7 (C7), a Potential Tumor Suppressor, Is an Immune-Related Prognostic Biomarker in Prostate Cancer (PC). PMID:32984006
Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques. PMID:32979349
Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease. PMID:32978267
PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin. PMID:32978259
Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries. PMID:32973800
Maternal-fetal genetic interactions, imprinting, and risk of placental abruption. PMID:32972274
Comprehensive analysis on the expression levels and prognostic values of LOX family genes in kidney renal clear cell carcinoma. PMID:32970930
A Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action. PMID:32970276
Bioinformatics analysis and experimental validation of TTK as a biomarker for prognosis in non-small cell lung cancer. PMID:32969465
Identification of diagnostic and prognostic biomarkers, and candidate targeted agents for hepatitis B virus-associated early stage hepatocellular carcinoma based on RNA-sequencing data. PMID:32968453
T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration. PMID:32968060
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19. PMID:32966765
BCAS2, a protein enriched in advanced prostate cancer, interacts with NBS1 to enhance DNA double-strand break repair. PMID:32963349
Hypoketotic hypoglycemia in citrin deficiency: a case report. PMID:32962675
Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines. PMID:32961074
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency. PMID:32960813
Distinct peripheral blood monocyte and neutrophil transcriptional programs following intracerebral hemorrhage and different etiologies of ischemic stroke. PMID:32960689
In the blood: biomarkers for amyloid pathology and neurodegeneration in Alzheimer's disease. PMID:32954304
Designing custom CRISPR libraries for hypothesis-driven drug target discovery. PMID:32952937
Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption. PMID:32947816
Genetic Polymorphisms in Multispecific Transporters Mitigate Mercury Nephrotoxicity in an Artisanal and Small-Scale Gold Mining Community in Colombia. PMID:32946573
FOXL1 Regulates Lung Fibroblast Function via Multiple Mechanisms. PMID:32946266
PAWER: protein array web exploreR. PMID:32942983
UPLC-qTOF-MS Phytochemical Profile and Antiulcer Potential of Cyperus conglomeratus Rottb. Alcoholic Extract. PMID:32942704
Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate. PMID:32939018
Breaking Bottlenecks for the TCR Therapy of Cancer. PMID:32937956
Using Deep Learning to Extrapolate Protein Expression Measurements. PMID:32937025
Consistency and variation of protein subcellular location annotations. PMID:32935893
Therapeutic applications of the selective high affinity ligand drug SH7139 extend beyond non-Hodgkin's lymphoma to many other types of solid cancers. PMID:32934776
TMEM206 is a potential prognostic marker of hepatocellular carcinoma. PMID:32934741
Prognostic effects of the expression of inhibitor of DNA-binding family members on patients with lung adenocarcinoma. PMID:32934711
Effects of the Delta Opioid Receptor Agonist DADLE in a Novel Hypoxia-Reoxygenation Model on Human and Rat-Engineered Heart Tissue: A Pilot Study. PMID:32932811
An era of single-cell genomics consortia. PMID:32929222
Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism. PMID:32927708
Prospective evaluation of the lymph node proteome in dogs with multicentric lymphoma supplemented with sulforaphane. PMID:32926463
Pinpointing Cell Identity in Time and Space. PMID:32923457
Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models. PMID:32923168
The Landscape of CAR-T Cell Clinical Trials against Solid Tumors-A Comprehensive Overview. PMID:32916883
Proteome-wide Changes in the mdx-4cv Spleen due to Pathophysiological Cross Talk with Dystrophin-Deficient Skeletal Muscle. PMID:32916630
A Quantitative Proteome Map of the Human Body. PMID:32916130
Intestinal Receptor of SARS-CoV-2 in Inflamed IBD Tissue Seems Downregulated by HNF4A in Ileum and Upregulated by Interferon Regulating Factors in Colon. PMID:32915959
Cell type-specific genetic regulation of gene expression across human tissues. PMID:32913075
The Stress-Like Cancer Cell State Is a Consistent Component of Tumorigenesis. PMID:32910905
SLC25A51 is a mammalian mitochondrial NAD+ transporter. PMID:32906142
SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation. PMID:32905556
Regulation of the mitochondrial permeability transition pore and its effects on aging. PMID:32904375
CAR T Cell Therapy for Pediatric Brain Tumors. PMID:32903405
Integration of molecular profiles in a longitudinal wellness profiling cohort. PMID:32900998
Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton's Jelly-Derived Mesenchymal Stem Cells. PMID:32899389
Age-related copy number variations and expression levels of F-box protein FBXL20 predict ovarian cancer prognosis. PMID:32898767
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases. PMID:32895551
Targeting UDP-glucose dehydrogenase inhibits ovarian cancer growth and metastasis. PMID:32893977
GAB2 and GAB3 are expressed in a tumor stage-, grade- and histotype-dependent manner and are associated with shorter progression-free survival in ovarian cancer. PMID:32888136
Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain. PMID:32887883
Lipid Phosphate Phosphatases and Cancer. PMID:32887262
Genome-wide association study for circulating fibroblast growth factor 21 and 23. PMID:32884031
EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data. PMID:32883324
Thioredoxin-Related Transmembrane Proteins: TMX1 and Little Brothers TMX2, TMX3, TMX4 and TMX5. PMID:32878123
Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling. PMID:32876046
Fractional diffusion on the human proteome as an alternative to the multi-organ damage of SARS-CoV-2. PMID:32872802
Single-cell metabolic profiling of human cytotoxic T cells. PMID:32868913
Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. PMID:32867764
Plasma protein-based signature predicts distant metastasis and induction chemotherapy benefit in Nasopharyngeal Carcinoma. PMID:32863958
Central neurological complications and potential neuropathogenesis of COVID-19. PMID:32860569
microRNAs and Corresponding Targets Involved in Metastasis of Colorectal Cancer in Preclinical In Vivo Models. PMID:32859626
Genetically raised serum bilirubin levels and lung cancer: a cohort study and Mendelian randomisation using UK Biobank. PMID:32855344
Novel insights into the disease transcriptome of human diabetic glomeruli and tubulointerstitium. PMID:32853351
Learning the properties of adaptive regions with functional data analysis. PMID:32853200
Cellular diversity of the regenerating caudal fin. PMID:32851162
A Quantitative Analysis of Cellular Lipid Compositions During Acute Proteotoxic ER Stress Reveals Specificity in the Production of Asymmetric Lipids. PMID:32850859
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Colon Adenocarcinoma Metastasis. PMID:32850813
Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection. PMID:32850483
LC3-Associated Phagocytosis (LAP): A Potentially Influential Mediator of Efferocytosis-Related Tumor Progression and Aggressiveness. PMID:32850405
Low Expression of Claudin-7 as Potential Predictor of Distant Metastases in High-Grade Serous Ovarian Carcinoma Patients. PMID:32850397
Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells. PMID:32850342
Leveraging Public Single-Cell and Bulk Transcriptomic Datasets to Delineate MAIT Cell Roles and Phenotypic Characteristics in Human Malignancies. PMID:32849590
The Endosomal Recycling Pathway-At the Crossroads of the Cell. PMID:32842549
DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas. PMID:32838940
Clustering analysis of tumor metabolic networks. PMID:32838750
Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. PMID:32838361
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. PMID:32832599
The intermembrane space protein Mix23 is a novel stress-induced mitochondrial import factor. PMID:32826315
Proteomic Analysis of Exosomes for Discovery of Protein Biomarkers for Prostate and Bladder Cancer. PMID:32825017
Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells. PMID:32823874
A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions. PMID:32822567
SRSF1 regulates exosome microRNA enrichment in human cancer cells. PMID:32819370
Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris. PMID:32817591
Multiomic blood correlates of genetic risk identify presymptomatic disease alterations. PMID:32817414
Tracking the carbons supplying gluconeogenesis. PMID:32817317
Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner. PMID:32816606
Favorable therapeutic response after anti-Mesothelin antibody-drug conjugate treatment requires high expression of Mesothelin in tumor cells. PMID:32815024
Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt. PMID:32814826
Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets. PMID:32814578
The mitochondrial transcription machinery genes are upregulated in acute myeloid leukemia and associated with poor clinical outcome. PMID:32812906
Enzymatic Noncovalent Synthesis. PMID:32812754
Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation. PMID:32812257
An Exploration of Social Cognition in Children with Different Degrees of Genetic Deletion in Williams Syndrome. PMID:32812194
Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis? PMID:32811540
GFAP at 50. PMID:32811163
Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips. PMID:32807988
The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer. PMID:32802887
When Is an In Silico Representation a Digital Twin? A Biopharmaceutical Industry Approach to the Digital Twin Concept. PMID:32797270
Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks. PMID:32796035
The methylation status of the chemerin promoter region located from - 252 to + 258 bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels. PMID:32792625
Guinea pig cytomegalovirus trimer complex gH/gL/gO uses PDGFRA as universal receptor for cell fusion and entry. PMID:32791352
SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule. PMID:32791255
Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion. PMID:32790176
Combining Gene-Disease Associations with Single-Cell Gene Expression Data Provides Anatomy-Specific Subnetworks in Age-Related Macular Degeneration. PMID:32789304
The prognostic value of HGF-c-MET signaling pathway in Gastric Cancer: a study based on TCGA and GEO databases. PMID:32788873
Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane. PMID:32788342
Snca-GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding. PMID:32788297
COVID-19 and comorbidities: Deleterious impact on infected patients. PMID:32788073
Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility. PMID:32785227
C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients with Gestational Diabetes Mellitus: A Case-Control Study. PMID:32785102
Expression and clinical significance of methyl-CpG binding domain protein 2 in high-grade serous ovarian cancer. PMID:32782591
Identification of a five-gene signature for predicting the progression and prognosis of stage I endometrial carcinoma. PMID:32782557
Integrative Genomic Analysis Reveals Four Protein Biomarkers for Platelet Traits. PMID:32781905
Characterization of the different oligomeric states of the DAN family antagonists SOSTDC1 and SOST. PMID:32779697
Building the vertebrate codex using the gene breaking protein trap library. PMID:32779569
Presence of SARS-Coronavirus-2 in the Ileal Mucosa: Another Evidence for Infection of GI Tract by This Virus. PMID:32777284
Gene expression of the IGF hormones and IGF binding proteins across time and tissues in a model reptile. PMID:32776803
FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease. PMID:32776417
Expression of smooth muscle-like effectors and core cardiomyocyte regulators in the contractile papillae of Ciona. PMID:32774829
Discovery and validation of surface N-glycoproteins in MM cell lines and patient samples uncovers immunotherapy targets. PMID:32771993
TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion. PMID:32767843
Renin-angiotensin II-aldosterone axis in SARS-CoV-2-associated xerostomia. PMID:32767801
Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research. PMID:32767122
Identification of the association between HMMR expression and progression of hepatocellular carcinoma via construction of a co-expression network. PMID:32765791
Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice. PMID:32764719
Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence. PMID:32764696
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front. PMID:32763154
Genome-wide methylation patterns predict clinical benefit of immunotherapy in lung cancer. PMID:32762727
Association of WNT7B and RSPO1 with Axial Length in School Children. PMID:32761137
Systems Biology Will Direct Vascular-Targeted Therapy for Obesity. PMID:32760294
Abnormal expression and prognostic significance of EPB41L1 in kidney renal clear cell carcinoma based on data mining. PMID:32760223
Bioinformatic Analysis of Correlation between Immune Infiltration and COVID-19 in Cancer Patients. PMID:32760213
Collagen Type III Alpha 1 chain regulated by GATA-Binding Protein 6 affects Type II IFN response and propanoate metabolism in the recurrence of lower grade glioma. PMID:32757451
Expression pattern, regulation, and clinical significance of TOX in breast cancer. PMID:32757053
Cerebral Immunohistochemical Characterization of the H2S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma. PMID:32754111
IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion. PMID:32753652
The Clinicopathological and Prognostic Significance of Nrf2 and Keap1 Expression in Hepatocellular Carcinoma. PMID:32751896
An overview of signaling pathways regulating YAP/TAZ activity. PMID:32748155
Integrative Omics Analyses Reveal Epigenetic Memory in Diabetic Renal Cells Regulating Genes Associated With Kidney Dysfunction. PMID:32747424
ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair. PMID:32744506
Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. PMID:32737331
Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer. PMID:32737302
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality. PMID:32737166
Molecular profiling of immune cell-enriched Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) interacting protein USP13. PMID:32735883
Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA. PMID:32735619
The Link Between the Mitochondrial Fatty Acid Oxidation Derangement and Kidney Injury. PMID:32733282
Systems Biology Approaches to Understand the Host-Microbiome Interactions in Neurodegenerative Diseases. PMID:32733199
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine. PMID:32730777
The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics. PMID:32728795
Occupancy maps of 208 chromatin-associated proteins in one human cell type. PMID:32728244
Lysosome-targeting chimaeras for degradation of extracellular proteins. PMID:32728216
Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer. PMID:32728173
Pyk2 Regulates Human Papillomavirus Replication by Tyrosine Phosphorylation of the E2 Protein. PMID:32727877
CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma. PMID:32727598
Multiple formin proteins participate in glioblastoma migration. PMID:32727404
The Interplay of Tumor Stroma and Translational Factors in Endometrial Cancer. PMID:32726992
Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer. PMID:32726752
Breed Differences in Dog Cognition Associated with Brain-Expressed Genes and Neurological Functions. PMID:32726413
In silico identification of the prognostic biomarkers and therapeutic targets associated with cancer stem cell characteristics of glioma. PMID:32725165
Mining the prognostic significance of the GINS2 gene in human breast cancer using bioinformatics analysis. PMID:32724372
Tumor Necrosis Factor Receptor SF10A (TNFRSF10A) SNPs Correlate With Corticosteroid Response in Duchenne Muscular Dystrophy. PMID:32719714
Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model. PMID:32719544
Insights into the skin of caecilian amphibians from gene expression profiles. PMID:32718305
Piggybacking on Classical Import and Other Non-Classical Mechanisms of Nuclear Import Appear Highly Prevalent within the Human Proteome. PMID:32718019
The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis. PMID:32717840
The protein expression profile of ACE2 in human tissues. PMID:32715618
Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease. PMID:32714578
Conventional protein kinase C in the brain: 40 years later. PMID:32714576
Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer's disease. PMID:32711556
Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD. PMID:32710014
Guarding the Genome: CENP-A-Chromatin in Health and Cancer. PMID:32708729
Chemokine Receptors CCR1 and CCR2 on Peripheral Blood Mononuclear Cells of Newly Diagnosed Patients with the CD38-Positive Chronic Lymphocytic Leukemia. PMID:32708233
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma. PMID:32707078
Downregulation of miR‑193a‑3p via targeting cyclin D1 in thyroid cancer. PMID:32705210
Transcriptomic comparison of human and mouse brain microvessels. PMID:32704093
Megalin/lipoprotein receptor-related protein 2 autoimmunity and kidney disease. PMID:32701075
Promoting crystallization of intrinsic membrane proteins with conjugated micelles. PMID:32699228
Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease. PMID:32696702
Artificial miRNAs targeting CAG repeat expansion in ORFs cause rapid deadenylation and translation inhibition of mutant transcripts. PMID:32696070
Analysis of m6A RNA methylation in Caenorhabditis elegans. PMID:32695436
Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours. PMID:32694827
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. PMID:32694731
FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation. PMID:32694203
Cellular Imprinting Proteomics Assay: A Novel Method for Detection of Neural and Ocular Disorders Applied to Congenital Zika Virus Syndrome. PMID:32686424
MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling. PMID:32681036
ECRG2, a novel transcriptional target of p53, modulates cancer cell sensitivity to DNA damage. PMID:32681017
Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines. PMID:32680547
Gene expression profiling identifies the role of Zac1 in cervical cancer metastasis. PMID:32678267
Secreted Frizzled-Related Protein 4 (SFRP4) Is an Independent Prognostic Marker in Prostate Cancers Lacking TMPRSS2: ERG Fusions. PMID:32677026
The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction. PMID:32670277
Brainstem Organoids From Human Pluripotent Stem Cells. PMID:32670003
A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells. PMID:32669955
Estimation of Hub Genes and Infiltrating Immune Cells in Non-Smoking Females with Lung Adenocarcinoma by Integrated Bioinformatic Analysis. PMID:32669531
Indication of Premelanosome Protein (PMEL) Expression Outside of Pigmented Bovine Skin Suggests Functions Beyond Eumelanogenesis. PMID:32668786
Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation. PMID:32667968
SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis. PMID:32664949
Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells. PMID:32664515
HRT Atlas v1.0 database: redefining human and mouse housekeeping genes and candidate reference transcripts by mining massive RNA-seq datasets. PMID:32663312
Enhancer-gene rewiring in the pathogenesis of Quebec platelet disorder. PMID:32663239
Metabolic Messengers: Adiponectin. PMID:32661510
New Insights on Genetic Diagnostics in Cardiomyopathy and Arrhythmia Patients Gained by Stepwise Exome Data Analysis. PMID:32659924
Chromatin network markers of leukemia. PMID:32657405
Abl1 deletion in gut stem cells suppresses p53 induction and promotes colitis-associated tumor formation. PMID:32652042
Endocrine Significance of SARS-CoV-2's Reliance on ACE2. PMID:32652001
Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury. PMID:32651223
Quantitative characterization of tumor cell-free DNA shortening. PMID:32650715
Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins. PMID:32647060
Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. PMID:32646997
Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome. PMID:32645919
Serine Incorporator 2 (SERINC2) Expression Predicts an Unfavorable Prognosis of Low-Grade Glioma (LGG): Evidence from Bioinformatics Analysis. PMID:32642801
CRISPR-based functional genomics for neurological disease. PMID:32641861
SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle. PMID:32641214
Clinical validation of the novel HDAC6 radiotracer [18F]EKZ-001 in the human brain. PMID:32638097
A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic. PMID:32637960
Systematic analysis reveals a functional role for STAMBPL1 in the epithelial-mesenchymal transition process across multiple carcinomas. PMID:32636467
Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury. PMID:32636391
Lipid Signaling in Ocular Neovascularization. PMID:32635437
Identification of miRNA Master Regulators in Breast Cancer. PMID:32635183
HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia. PMID:32634239
Variance-adjusted Mahalanobis (VAM): a fast and accurate method for cell-specific gene set scoring. PMID:32633778
Muscle-derived Myoglianin regulates Drosophila imaginal disc growth. PMID:32633716
Mitoribosome Defect in Hepatocellular Carcinoma Promotes an Aggressive Phenotype with Suppressed Immune Reaction. PMID:32629612
Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling. PMID:32629387
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections. PMID:32628701
Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits. PMID:32628676
Long-term ACE Inhibitor/ARB Use Is Associated With Severe Renal Dysfunction and Acute Kidney Injury in Patients With Severe COVID-19: Results From a Referral Center Cohort in the Northeast of France. PMID:32623470
A brief review of liver injury in patients with Corona Virus Disease-19 during the pandemic. PMID:32621206
Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome. PMID:32619492
The transcriptional signature associated with human motile cilia. PMID:32616903
ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins. PMID:32616830
Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies. PMID:32612606
Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular Pathology. PMID:32612540
Physiological blood-brain transport is impaired with age by a shift in transcytosis. PMID:32612231
Inhibition of Bruton's TK regulates macrophage NF-κB and NLRP3 inflammasome activation in metabolic inflammation. PMID:32608058
Candidate protein biomarkers in pancreatic neuroendocrine neoplasms grade 3. PMID:32606315
The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells. PMID:32603710
Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection. PMID:32602627
Proximity Ligation Assay as a Tool for Antibody Validation in Human Tissues. PMID:32602410
Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies. PMID:32601394
Profiling tear proteomes of patients with unilateral relapsed Behcet's disease-associated uveitis using data-independent acquisition proteomics. PMID:32596040
Analysis of Expression and Its Clinical Significance of the Secreted Phosphoprotein 1 in Lung Adenocarcinoma. PMID:32595698
High prevalence of plasma lipid abnormalities in human and canine Duchenne and Becker muscular dystrophies depicts a new type of primary genetic dyslipidemia. PMID:32593511
COVID-19 and non-alcoholic fatty liver disease: Two intersecting pandemics. PMID:32589264
Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice†. PMID:32588889
DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer. PMID:32588770
The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions. PMID:32587962
Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development. PMID:32587777
COVID-19 pandemic: Its impact on liver disease and liver transplantation. PMID:32587443
Identification of Cell-Surface Proteins Endocytosed by Human Brain Microvascular Endothelial Cells In Vitro. PMID:32585920
Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters. PMID:32582958
cfNOMe - A single assay for comprehensive epigenetic analyses of cell-free DNA. PMID:32580754
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma. PMID:32579974
Profiling the circulating mRNA transcriptome in human liver disease. PMID:32577166
Regulation of cellular senescence by eukaryotic members of the FAH superfamily - A role in calcium homeostasis? PMID:32574647
Elucidation of cellular targets and exploitation of the receptor-binding domain of SARS-CoV-2 for vaccine and monoclonal antibody synthesis. PMID:32573788
The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence-associated epigenomic remodeling. PMID:32573059
Matriptase processing of APLP1 ectodomain alters its homodimerization. PMID:32572095
Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury. PMID:32571916
Conserved Small Nucleotidic Elements at the Origin of Concerted piRNA Biogenesis from Genes and lncRNAs. PMID:32570966
Identification of a Robust Five-Gene Risk Model in Prostate Cancer: A Robust Likelihood-Based Survival Analysis. PMID:32566639
A Sample Preparation Protocol for High Throughput Immunofluorescence of Suspension Cells on an Adherent Surface. PMID:32564662
Evidence for endothelial-to-mesenchymal transition in human brain arteriovenous malformations. PMID:32564509
Empagliflozin suppresses inflammation and protects against acute septic renal injury. PMID:32564182
Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis. PMID:32561683
Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn's Disease. PMID:32561494
Mapping of CaM, S100A1 and PIP2-Binding Epitopes in the Intracellular N- and C-Termini of TRPM4. PMID:32560560
Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target. PMID:32560530
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. PMID:32559194
Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2. PMID:32558639
Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis. PMID:32557728
Identification of important genes and drug repurposing based on clinical-centered analysis across human cancers. PMID:32555508
GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma. PMID:32555306
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. PMID:32554929
HDAC9 deficiency promotes tumor progression by decreasing the CD8+ dendritic cell infiltration of the tumor microenvironment. PMID:32554611
Apolipoprotein D. PMID:32554047
Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging. PMID:32553207
LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome. PMID:32553112
Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells. PMID:32552827
The effect of age on the microarchitecture and profile of gene expression in femoral head and neck bone from patients with osteoarthritis. PMID:32551338
Tissue-Specific Requirement for the GINS Complex During Zebrafish Development. PMID:32548116
Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor. PMID:32546533
The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly. PMID:32542055
Unveiling prognostics biomarkers of tyrosine metabolism reprogramming in liver cancer by cross-platform gene expression analyses. PMID:32542016
Dynamic rewiring of the human interactome by interferon signaling. PMID:32539747
Integrated Analyses Identify Immune-Related Signature Associated with Qingyihuaji Formula for Treatment of Pancreatic Ductal Adenocarcinoma Using Network Pharmacology and Weighted Gene Co-Expression Network. PMID:32537471
Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance. PMID:32536688
Why Great Mitotic Inhibitors Make Poor Cancer Drugs. PMID:32536592
PET Imaging of the Natural Killer Cell Activation Receptor NKp30. PMID:32532927
Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways. PMID:32526885
GOcats: A tool for categorizing Gene Ontology into subgraphs of user-defined concepts. PMID:32525872
Systematic Humanization of the Yeast Cytoskeleton Discerns Functionally Replaceable from Divergent Human Genes. PMID:32522745
Comprehensive analysis reveals a metabolic ten-gene signature in hepatocellular carcinoma. PMID:32518728
Severe chronic kidney disease environment reduced calcium-sensing receptor expression in parathyroid glands of adenine-induced rats even without high phosphorus diet. PMID:32517664
A framework for integrating directed and undirected annotations to build explanatory models of cis-eQTL data. PMID:32516306
Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice. PMID:32516134
The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer. PMID:32515734
Downexpression of HSD17B6 correlates with clinical prognosis and tumor immune infiltrates in hepatocellular carcinoma. PMID:32514254
SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease. PMID:32511461
Overexpressed gene signature of EPH receptor A/B family in cancer patients-comprehensive analyses from the public high-throughput database. PMID:32509099
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint. PMID:32508832
Tetraspanins in the regulation of mast cell function. PMID:32507938
Hepatic consequences of COVID-19 infection. Lapping or biting? PMID:32507608
COVID-19: A Global Threat to the Nervous System. PMID:32506549
Single-Cell RNA Sequencing of Human, Macaque, and Mouse Testes Uncovers Conserved and Divergent Features of Mammalian Spermatogenesis. PMID:32504559
Analysis of human metabolism by reducing the complexity of the genome-scale models using redHUMAN. PMID:32499584
Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned so Far. PMID:32498343
Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells. PMID:32492424
Tox21BodyMap: a webtool to map chemical effects on the human body. PMID:32491175
Decoding the Body Language of Immunity: Tackling the Immune System at the Organism Level. PMID:32490290
Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. PMID:32487735
Significance of STAT3 in Immune Infiltration and Drug Response in Cancer. PMID:32486001
Emerging Roles of Gemin5: From snRNPs Assembly to Translation Control. PMID:32485878
Age-Related Changes in Hair Shaft Protein Profiling and Genetically Variant Peptides. PMID:32485593
TRPM4 is overexpressed in breast cancer associated with estrogen response and epithelial-mesenchymal transition gene sets. PMID:32484822
The role of 3'UTR-protein complexes in the regulation of protein multifunctionality and subcellular localization. PMID:32484544
Partial proteolysis improves the identification of the extracellular segments of transmembrane proteins by surface biotinylation. PMID:32483232
Integrated omics in Drosophila uncover a circadian kinome. PMID:32483184
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor. PMID:32483149
Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation. PMID:32482897
Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia. PMID:32481505
Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens. PMID:32477965
Cardiac involvement in a cross-sectional cohort of myotonic dystrophies and other skeletal myopathies. PMID:32476276
Annexin A1 is a Potential Novel Biomarker of Congestion in Acute Heart Failure. PMID:32473378
Buccal Mucosa Biomarkers in Alzheimer's Disease. PMID:32468458
Endometrial profilin 1: a key player in embryo-endometrial crosstalk. PMID:32466630
Personalized whole-body models integrate metabolism, physiology, and the gut microbiome. PMID:32463598
Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors. PMID:32463365
Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases. PMID:32462403
Flexible Mixture Model Approaches That Accommodate Footprint Size Variability for Robust Detection of Balancing Selection. PMID:32462188
AKNA Is a Potential Prognostic Biomarker in Gastric Cancer and Function as a Tumor Suppressor by Modulating EMT-Related Pathways. PMID:32462010
Quantitative analysis of Y-Chromosome gene expression across 36 human tissues. PMID:32461223
Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma. PMID:32460791
Integration of Heterogeneous Experimental Data Improves Global Map of Human Protein Complexes. PMID:32457940
A Bitter Taste in Your Heart. PMID:32457649
The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target? PMID:32457627
Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding. PMID:32457219
The Role of Selected Chemokines and Their Receptors in the Development of Gliomas. PMID:32456359
MicrobioLink: An Integrated Computational Pipeline to Infer Functional Effects of Microbiome-Host Interactions. PMID:32455748
A bidirectional Mendelian randomization study supports causal effects of kidney function on blood pressure. PMID:32454124
Chemerin as a Driver of Hypertension: A Consideration. PMID:32453820
Identification of Tumor Antigens in the HLA Peptidome of Patient-derived Xenograft Tumors in Mouse. PMID:32451349
PseudoChecker: an integrated online platform for gene inactivation inference. PMID:32449938
Gene X environment: the cellular environment governs the transcriptional response to environmental chemicals. PMID:32448403
Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus. PMID:32447426
Glycoprotein nonmetastatic melanoma protein B: A key mediator and an emerging therapeutic target in autoimmune diseases. PMID:32445534
TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling. PMID:32444641
Human genetic dissection of papillomavirus-driven diseases: new insight into their pathogenesis. PMID:32435828
The CD47-SIRPα Immune Checkpoint. PMID:32433947
Genetic Determinants of Reduced Arsenic Metabolism Efficiency in the 10q24.32 Region Are Associated With Reduced AS3MT Expression in Multiple Human Tissue Types. PMID:32433756
Comprehensive analysis of the value of RAB family genes in prognosis of breast invasive carcinoma. PMID:32432324
Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability. PMID:32429325
Anti-vimentin, anti-TUFM, anti-NAP1L1 and anti-DPYSL2 nanobodies display cytotoxic effect and reduce glioblastoma cell migration. PMID:32426045
Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract. PMID:32425701
Secretome-Based Screening in Target Discovery. PMID:32425085
Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains. PMID:32424074
Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking. PMID:32423029
Rare Genetic Diseases: Nature's Experiments on Human Development. PMID:32422592
Progress, Challenges, and Surprises in Annotating the Human Genome. PMID:32421357
Machine Learning Supports Long Noncoding RNAs as Expression Markers for Endometrial Carcinoma. PMID:32420338
Ten-eleven translocation proteins and their role beyond DNA demethylation - what we can learn from the fly. PMID:32419604
A Fast and Memory-Efficient Spectral Library Search Algorithm Using Locality-Sensitive Hashing. PMID:32415809
Art and Science of the Cellular Mesoscale. PMID:32413324
Association between SNAP25 and human glioblastoma multiform: a comprehensive bioinformatic analysis. PMID:32412599
Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq. PMID:32410729
BAHD1 haploinsufficiency results in anxiety-like phenotypes in male mice. PMID:32407325
Identification of transforming growth factor beta induced (TGFBI) as an immune-related prognostic factor in clear cell renal cell carcinoma (ccRCC). PMID:32406866
Spatio-Temporal Roles of ASD-Associated Variants in Human Brain Development. PMID:32403330
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP. PMID:32402273
Urinary Extracellular Vesicles and Salt-Losing Tubulopathies: A Proteomic Approach. PMID:32397528
StanDep: Capturing transcriptomic variability improves context-specific metabolic models. PMID:32396573
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. PMID:32393898
The emerging roles of WBP2 oncogene in human cancers. PMID:32393834
Nucleoside Reverse Transcriptase Inhibitor Interaction with Human Equilibrative Nucleoside Transporters 1 and 2. PMID:32393653
Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors. PMID:32388565
Mantis-ml: Disease-Agnostic Gene Prioritization from High-Throughput Genomic Screens by Stochastic Semi-supervised Learning. PMID:32386536
Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes. PMID:32385057
Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. PMID:32382484
eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled. PMID:32381507
Identification and validation of the angiogenic genes for constructing diagnostic, prognostic, and recurrence models for hepatocellular carcinoma. PMID:32379058
Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation. PMID:32376919
Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 Adrenoceptors. PMID:32376421
Severe acute respiratory syndrome coronavirus 2 detection in the female lower genital tract. PMID:32376320
Integrative analyses of the RNA modification machinery reveal tissue- and cancer-specific signatures. PMID:32375858
MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth. PMID:32371956
A single-cell transcriptomic landscape of primate arterial aging. PMID:32371953
Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues. PMID:32371927
Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding. PMID:32369656
Towards the routine use of in silico screenings for drug discovery using metabolic modelling. PMID:32369553
Tryptophan catabolism reflects disease activity in human tuberculosis. PMID:32369456
Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation. PMID:32366865
TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. PMID:32366851
Proteomics illuminates fat as key tissue in aging. PMID:32366668
Cystathionine-β-Synthase: Molecular Regulation and Pharmacological Inhibition. PMID:32365821
A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development: IUPHAR Review 29. PMID:32358833
Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche. PMID:32354994
Is SARS-CoV-2 Also an Enteric Pathogen With Potential Fecal-Oral Transmission? A COVID-19 Virological and Clinical Review. PMID:32353371
TRP Channels as Emerging Therapeutic Targets for Neurodegenerative Diseases. PMID:32351395
Whole transcriptome analysis and validation of metabolic pathways in subcutaneous adipose tissues during FGF21-induced weight loss in non-human primates. PMID:32350364
Hepatocyte nuclear factor-4α regulates expression of the serotonin transporter in intestinal epithelial cells. PMID:32348179
T cell costimulation, checkpoint inhibitors and anti-tumor therapy. PMID:32345776
Shared genetic architecture and casual relationship between leptin levels and type 2 diabetes: large-scale cross-trait meta-analysis and Mendelian randomization analysis. PMID:32341051
Urinary Exosomal MicroRNA Signatures in Nephrotic, Biopsy-Proven Diabetic Nephropathy. PMID:32340338
Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression. PMID:32338600
The Oncogenic Role of CENPA in Hepatocellular Carcinoma Development: Evidence from Bioinformatic Analysis. PMID:32337237
Identification of genes involved in the evolution of human intelligence through combination of inter-species and intra-species genetic variations. PMID:32337102
Expression of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in the Gut of Patients With IBD. PMID:32333601
MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer. PMID:32332866
Adsorption of a styrene maleic acid (SMA) copolymer-stabilized phospholipid nanodisc on a solid-supported planar lipid bilayer. PMID:32330753
Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3. PMID:32330444
Translational genomics for achieving higher genetic gains in groundnut. PMID:32328677
Genetic Roadmap for Kidney Involvement of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. PMID:32327413
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression. PMID:32326089
Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis. PMID:32325894
Tissue-selective regulation of protein homeostasis and unfolded protein response signalling in sporadic ALS. PMID:32324341
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer. PMID:32322170
Consistent RNA sequencing contamination in GTEx and other data sets. PMID:32321923
Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population. PMID:32321463
Risks of ACE Inhibitor and ARB Usage in COVID-19: Evaluating the Evidence. PMID:32320478
SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines. PMID:32319594
Direct trafficking pathways from the Golgi apparatus to the plasma membrane. PMID:32317144
Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4. PMID:32316263
PDZ Domains as Drug Targets. PMID:32313833
Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection. PMID:32311451
GDF15: A Hormone Conveying Somatic Distress to the Brain. PMID:32310257
Functional Amyloids and their Possible Influence on Alzheimer Disease. PMID:32309597
Ribosomal protein RACK1 enhances translation of poliovirus and other viral IRESs. PMID:32308198
ALS-associated genes in SCA2 mouse spinal cord transcriptomes. PMID:32307524
Histone Deacetylases in Kidney Physiology and Acute Kidney Injury. PMID:32303277
Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia. PMID:32302554
Nitrogen Metabolism in Cancer and Immunity. PMID:32302552
Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes. PMID:32302527
Plasma membrane expression of G protein-coupled estrogen receptor (GPER)/G protein-coupled receptor 30 (GPR30) is associated with worse outcome in metachronous contralateral breast cancer. PMID:32302351
Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice†. PMID:32301969
NCAPG Is a Promising Therapeutic Target Across Different Tumor Types. PMID:32300299
Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers. PMID:32298395
The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling. PMID:32296774
PTHrP, A Biomarker for CNS Metastasis in Triple-Negative Breast Cancer and Selection for Adjuvant Chemotherapy in Node-Negative Disease. PMID:32296756
Transcriptome analysis revealed key prognostic genes and microRNAs in hepatocellular carcinoma. PMID:32296612
A WIZ/Cohesin/CTCF Complex Anchors DNA Loops to Define Gene Expression and Cell Identity. PMID:32294452
Molecular effects of dADD1 misexpression in chromatin organization and transcription. PMID:32293240
Dysregulation of Type II Transmembrane Serine Proteases and Ligand-Dependent Activation of MET in Urological Cancers. PMID:32290402
Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort. PMID:32290310
Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome. PMID:32286305
Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine. PMID:32284825
Meltome atlas-thermal proteome stability across the tree of life. PMID:32284610
Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease. PMID:32277752
Methionine Dependence of Cancer. PMID:32276408
Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis. PMID:32275865
Characteristics and Mechanism of Liver Injury in 2019 Coronavirus Disease. PMID:32274341
Differential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma. PMID:32273545
Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH. PMID:32271712
High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. PMID:32271093
Translational Control of Secretory Proteins in Health and Disease. PMID:32268488
Systems Biochemistry Approaches to Defining Mitochondrial Protein Function. PMID:32268114
DirectMX - One-Step Reconstitution of Membrane Proteins From Crude Cell Membranes Into Salipro Nanoparticles. PMID:32266242
Erosion of Gene Co-expression Networks Reveal Deregulation of Immune System Processes in Late-Onset Alzheimer's Disease. PMID:32265636
Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines. PMID:32265286
CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110. PMID:32264921
A Key mRNA-miRNA-lncRNA Competing Endogenous RNA Triple Sub-network Linked to Diagnosis and Prognosis of Hepatocellular Carcinoma. PMID:32257949
Low RAB6C expression is a predictor of tamoxifen benefit in estrogen receptor-positive/progesterone receptor-negative breast cancer. PMID:32257197
CCNB2, NUSAP1 and TK1 are associated with the prognosis and progression of hepatocellular carcinoma, as revealed by co-expression analysis. PMID:32256749
Precision Cardio-Oncology: a Systems-Based Perspective on Cardiotoxicity of Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors. PMID:32253744
Nucleolin-Sle A Glycoforms as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer Cells. PMID:32252346
Pulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features. PMID:32251643
Discovery of a selective inhibitor of doublecortin like kinase 1. PMID:32251410
Urine Extracellular Vesicle GATA2 mRNA Discriminates Biopsy Result in Men with Suspicion of Prostate Cancer. PMID:32250729
Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside. PMID:32247663
Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles. PMID:32245988
Safety and Feasibility of PARP1/2 Imaging with 18F-PARPi in Patients with Head and Neck Cancer. PMID:32245901
Phosphoproteomic characterization of the signaling network resulting from activation of the chemokine receptor CCR2. PMID:32241914
Differential co-expression analysis reveals early stage transcriptomic decoupling in alzheimer's disease. PMID:32241275
Pseudogene-gene functional networks are prognostic of patient survival in breast cancer. PMID:32241256
Cell-type diversity and regionalized gene expression in the planarian intestine. PMID:32240093
Development and validation of a survival model for lung adenocarcinoma based on autophagy-associated genes. PMID:32238163
Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex. PMID:32235678
Multiomics Evaluation of Gastrointestinal and Other Clinical Characteristics of COVID-19. PMID:32234303
Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage. PMID:32229571
Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro. PMID:32228452
IL-4R is expressed on alpha and beta cells of human pancreata. PMID:32224156
Investigating LGALS3BP/90 K glycoprotein in the cerebrospinal fluid of patients with neurological diseases. PMID:32221402
Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer. PMID:32218990
Identification of hub genes associated with outcome of clear cell renal cell carcinoma. PMID:32218839
Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth. PMID:32218467
Heparan sulfate is a clearance receptor for aberrant extracellular proteins. PMID:32211892
Leucine Rich Repeat Kinase 2 and Innate Immunity. PMID:32210756
Cellular processes involved in lung cancer cells exposed to direct current electric field. PMID:32210363
Anatomy of a viral entry platform differentially functionalized by integrins α3 and α6. PMID:32210347
An atlas of human metabolism. PMID:32209698
The signal peptide as a new target for drug design. PMID:32209293
Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease. PMID:32208444
Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer. PMID:32207251
Mass Spectrometry Advances and Perspectives for the Characterization of Emerging Adoptive Cell Therapies. PMID:32204371
Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer. PMID:32201920
Tumor cell-organized fibronectin maintenance of a dormant breast cancer population. PMID:32195352
An array of 60,000 antibodies for proteome-scale antibody generation and target discovery. PMID:32195335
Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma. PMID:32194798
Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. PMID:32193359
5-Aza-2'-deoxycytidine advances the epithelial-mesenchymal transition of breast cancer cells by demethylating Sipa1 promoter-proximal elements. PMID:32193333
Brain manganese and the balance between essential roles and neurotoxicity. PMID:32188696
Discovery of non-HLA antibodies associated with cardiac allograft rejection and development and validation of a non-HLA antigen multiplex panel: From bench to bedside. PMID:32185871
Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress. PMID:32183456
An Overview on ERAP Roles in Infectious Diseases. PMID:32183384
Ependymoma Pediatric Brain Tumor Protein Fingerprinting by Integrated Mass Spectrometry Platforms: A Pilot Investigation. PMID:32183175
Genomic Landscape and Mutational Spectrum of ADAMTS Family Genes in Mendelian Disorders Based on Gene Evidence Review for Variant Interpretation. PMID:32183147
Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae. PMID:32182256
Catestatin improves insulin sensitivity by attenuating endoplasmic reticulum stress: In vivo and in silico validation. PMID:32180905
The transcription factor CUX1 negatively regulates invasion in castrate resistant prostate cancer. PMID:32180898
Combination of PD-1 Inhibitor and OX40 Agonist Induces Tumor Rejection and Immune Memory in Mouse Models of Pancreatic Cancer. PMID:32179091
End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression. PMID:32179051
A FITM1-Related Methylation Signature Predicts the Prognosis of Patients With Non-Viral Hepatocellular Carcinoma. PMID:32174969
PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers. PMID:32172476
Machine learning prediction of oncology drug targets based on protein and network properties. PMID:32171238
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake. PMID:32170013
Membrane mucins of the intestine at a glance. PMID:32169835
APEX1 is a novel diagnostic and prognostic biomarker for hepatocellular carcinoma. PMID:32167932
A miRNA- and mRNA-seq-Based Feature Selection Approach for Kidney Cancer Biomakers. PMID:32165847
A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation. PMID:32163402
Toward Development of the Male Pill: A Decade of Potential Non-hormonal Contraceptive Targets. PMID:32161754
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy. PMID:32161261
CD29 identifies IFN-γ-producing human CD8+ T cells with an increased cytotoxic potential. PMID:32161126
Fibroblast-specific genome-scale modelling predicts an imbalance in amino acid metabolism in Refsum disease. PMID:32160399
Genomics and Prognosis Analysis of Epithelial-Mesenchymal Transition in Glioma. PMID:32154177
A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs. PMID:32152546
Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs. PMID:32150922
CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation. PMID:32150608
A putative silencer variant in a spontaneous canine model of retinitis pigmentosa. PMID:32150541
Loss of Arhgef11 in the Dahl Salt-Sensitive Rat Protects Against Hypertension-Induced Renal Injury. PMID:32148127
Angiogenin and tRNA fragments in Parkinson's disease and neurodegeneration. PMID:32144338
KCML: a machine-learning framework for inference of multi-scale gene functions from genetic perturbation screens. PMID:32141232
Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases. PMID:32139877
A Caenorhabditis elegans Model for Integrating the Functions of Neuropsychiatric Risk Genes Identifies Components Required for Normal Dendritic Morphology. PMID:32132169
HDMAC: A Web-Based Interactive Program for High-Dimensional Analysis of Molecular Alterations in Cancer. PMID:32127576
Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease. PMID:32127447
The expression landscape of cachexia-inducing factors in human cancers. PMID:32125790
PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression. PMID:32125284
Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes. PMID:32122952
CDX2: A Prognostic Marker in Metastatic Colorectal Cancer Defining a Better BRAF Mutated and a Worse KRAS Mutated Subgroup. PMID:32117703
Identification and validation of key modules and hub genes associated with the pathological stage of oral squamous cell carcinoma by weighted gene co-expression network analysis. PMID:32117620
Germ Cell-Specific Gene 1-Like Protein Regulated by Splicing Factor CUGBP Elav-Like Family Member 5 and Primary Bile Acid Biosynthesis are Prognostic in Glioblastoma Multiforme. PMID:32117422
Tumor-Specific T Cell Activation in Malignant Brain Tumors. PMID:32117316
Expanding Clinical Presentations Due to Variations in THOC2 mRNA Nuclear Export Factor. PMID:32116545
The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. PMID:32116499
Dawn of a New RAMPage. PMID:32115276
FTO Facilitates Lung Adenocarcinoma Cell Progression by Activating Cell Migration Through mRNA Demethylation. PMID:32110044
Endometriotic cell culture contamination and authenticity: a source of bias in in vitro research? PMID:32106286
Insulin-like growth factor-binding proteins play a significant role in the molecular response to imatinib in chronic myeloid leukemia patients. PMID:32104232
Network Pharmacology-Based Investigation of the System-Level Molecular Mechanisms of the Hematopoietic Activity of Samul-Tang, a Traditional Korean Herbal Formula. PMID:32104198
Harnessing immunotherapy for pediatric T-cell malignancies. PMID:32103690
Identification of molecular markers associated with the progression and prognosis of endometrial cancer: a bioinformatic study. PMID:32099532
Peripheral-to-central immune communication at the area postrema glial-barrier following bleomycin-induced sterile lung injury in adult rats. PMID:32097765
Identification of putative biomarkers for Infantile Hemangiomas and Propranolol treatment via data integration. PMID:32094357
Two Novel FAM20C Variants in A Family with Raine Syndrome. PMID:32093234
Cytokine-Induced Guanylate Binding Protein 1 (GBP1) Release from Human Ovarian Cancer Cells. PMID:32093058
Transcriptome analyses reveal molecular mechanisms underlying phenotypic differences among transcriptional subtypes of glioblastoma. PMID:32091665
Development of a high affinity Anticalin® directed against human CD98hc for theranostic applications. PMID:32089738
Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D. PMID:32082316
Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers. PMID:32081859
Conditional Disorder in Small Heat-shock Proteins. PMID:32081587
Squamous differentiation requires G2/mitosis slippage to avoid apoptosis. PMID:32080348
The Relevance of Thimet Oligopeptidase in the Regulation of Energy Metabolism and Diet-Induced Obesity. PMID:32079362
Epigenetic Conservation Is a Beacon of Function: An Analysis Using Methcon5 Software for Studying Gene Methylation. PMID:32078366
REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. PMID:32075961
The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins. PMID:32075873
PPP2R5D-Related Intellectual Disability and Neurodevelopmental Delay: A Review of the Current Understanding of the Genetics and Biochemical Basis of the Disorder. PMID:32074998
Comparison of Prostate-Specific Membrane Antigen Expression Levels in Human Salivary Glands to Non-Human Primates and Rodents. PMID:32074455
Validating indicators of CNS disorders in a swine model of neurological disease. PMID:32074109
Neurotoxicity including posterior reversible encephalopathy syndrome after initiation of calcineurin inhibitors in transplanted methylmalonic acidemia patients: Two case reports and review of the literature. PMID:32071844
Integrated analysis of the roles and prognostic value of RNA binding proteins in lung adenocarcinoma. PMID:32071816
A census of pathway maps in cancer systems biology. PMID:32066900
The kinase polypharmacology landscape of clinical PARP inhibitors. PMID:32066817
Large epigenome-wide association study of childhood ADHD identifies peripheral DNA methylation associated with disease and polygenic risk burden. PMID:32066674
HMI-PRED: A Web Server for Structural Prediction of Host-Microbe Interactions Based on Interface Mimicry. PMID:32061934
Analysis of Ras-effector interaction competition in large intestine and colorectal cancer context. PMID:32057289
Restoration of MARCKS enhances chemosensitivity in cancer. PMID:32056006
VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury. PMID:32055648
EGFR modulates complement activation in head and neck squamous cell carcinoma. PMID:32054454
Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions. PMID:32054438
The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β. PMID:32053590
Mechanical regulation of glycolysis via cytoskeleton architecture. PMID:32051585
Using the Gibbs Function as a Measure of Human Brain Development Trends from Fetal Stage to Advanced Age. PMID:32046179
Relationship between NAMPT/PBEF/visfatin and prognosis of patients with malignant tumors: a systematic review and meta-analysis. PMID:32042801
A mutation map for human glycoside hydrolase genes. PMID:32039448
HSD17B13 truncated variant is associated with a mild hepatic phenotype in Wilson's Disease. PMID:32039348
Targeting GPCRs Against Cardiotoxicity Induced by Anticancer Treatments. PMID:32039239
Classification of Trispanins: A Diverse Group of Proteins That Function in Membrane Synthesis and Transport Mechanisms. PMID:32039202
The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer. PMID:32038501
Proteomic profiling and identification of significant markers from high-grade osteosarcoma after cryotherapy and irradiation. PMID:32034162
EV-101: A Phase I Study of Single-Agent Enfortumab Vedotin in Patients With Nectin-4-Positive Solid Tumors, Including Metastatic Urothelial Carcinoma. PMID:32031899
The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling. PMID:32029705
Systematic functional identification of cancer multi-drug resistance genes. PMID:32028983
Protein disulfide isomerases are promising targets for predicting the survival and tumor progression in glioma patients. PMID:32023222
Exploring Metabolic Consequences of CPS1 and CAD Dysregulation in Hepatocellular Carcinoma by Network Reconstruction. PMID:32021853
A Unique Regulation Region in the 3' UTR of HLA-G with a Promising Potential. PMID:32019184
The Water Channel Aquaporin 8 is a Critical Regulator of Intestinal Fluid Homeostasis in Collagenous Colitis. PMID:32016376
An optimized chemical-genetic method for cell-specific metabolic labeling of RNA. PMID:32015544
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine. PMID:32015474
Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy. PMID:32012846
IGF2BP3 From Physiology to Cancer: Novel Discoveries, Unsolved Issues, and Future Perspectives. PMID:32010687
Identification of differentially expressed protein-coding genes in lung adenocarcinomas. PMID:32010276
Dysregulated lncRNA-miRNA-mRNA Network Reveals Patient Survival-Associated Modules and RNA Binding Proteins in Invasive Breast Carcinoma. PMID:32010179
Complex impact of DNA methylation on transcriptional dysregulation across 22 human cancer types. PMID:32002550
Effect of small molecule signaling in PepFect14 transfection. PMID:31999754
GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents. PMID:31999650
The omics revolution: beyond genomics. A meeting report. PMID:31997976
Senescence-associated genes and non-coding RNAs function in pancreatic cancer progression. PMID:31997706
Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans. PMID:31996024
Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency. PMID:31995689
RNA editing as a therapeutic approach for retinal gene therapy requiring long coding sequences. PMID:31991730
Functional and transcriptomic characterization of cisplatin-resistant AGS and MKN-28 gastric cancer cell lines. PMID:31990955
Exploring genetic targets of psoriasis using genome wide association studies (GWAS) for drug repurposing. PMID:31988837
Fibroblast growth factor signaling in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: Paving the way to hepatocellular carcinoma. PMID:31988589
Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer. PMID:31988584
Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans. PMID:31987839
Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia. PMID:31985809
Single nucleotide polymorphisms in the dual specificity phosphatase genes and risk of necrotizing enterocolitis in premature infant. PMID:31985475
DNMT1 mutations leading to neurodegeneration paradoxically reflect on mitochondrial metabolism. PMID:31984424
Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation. PMID:31982949
Convergent systems-based approaches identify a role for OCIAD1 in Alzheimer's disease. PMID:31981980
A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population. PMID:31975031
ISOGO: Functional annotation of protein-coding splice variants. PMID:31974522
The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival. PMID:31968056
Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors. PMID:31967407
Aggregation of Omic Data and Secretome Prediction Enable the Discovery of Candidate Plasma Biomarkers for Beef Tenderness. PMID:31963926
Association of α/β-Hydrolase D16B with Bovine Conception Rate and Sperm Plasma Membrane Lipid Composition. PMID:31963602
The Genomes of the Livebearing Fish Species Poeciliopsis retropinna and Poeciliopsis turrubarensis Reflect Their Different Reproductive Strategies. PMID:31960923
Weighted gene co-expression network analysis identifies CCNA2 as a treatment target of prostate cancer through inhibiting cell cycle. PMID:31956366
Monogenic causes of non-obstructive azoospermia: challenges, established knowledge, limitations and perspectives. PMID:31955275
Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation. PMID:31953380
A comparison of gene expression and DNA methylation patterns across tissues and species. PMID:31953346
Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis. PMID:31953345
The ELIXIR Core Data Resources: fundamental infrastructure for the life sciences. PMID:31950984
miR-TV: an interactive microRNA Target Viewer for microRNA and target gene expression interrogation for human cancer studies. PMID:31950188
Beyond mass spectrometry, the next step in proteomics. PMID:31950079
The Role of Transient Receptor Potential Melastatin 7 (TRPM7) in Cell Viability: A Potential Target to Suppress Breast Cancer Cell Cycle. PMID:31947967
Direct Activation of TRPC3 Channels by the Antimalarial Agent Artemisinin. PMID:31947602
Control of Astrocyte Quiescence and Activation in a Synthetic Brain Hydrogel. PMID:31943839
Combined Expression of Plasma Thrombospondin-2 and CA19-9 for Diagnosis of Pancreatic Cancer and Distal Cholangiocarcinoma: A Proteome Approach. PMID:31943574
Polycystin 2 is increased in disease to protect against stress-induced cell death. PMID:31941974
De novo variants in exomes of congenital heart disease patients identify risk genes and pathways. PMID:31941532
Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor. PMID:31940495
Seminal fluid-mediated fitness effects in the simultaneously hermaphroditic flatworm Macrostomum lignano. PMID:31938489
Effect of miR-483-5p on apoptosis of lung cancer cells through targeting of RBM5. PMID:31938444
Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension. PMID:31937874
SeXY chromosomes and the immune system: reflections after a comparative study. PMID:31937374
SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation. PMID:31935717
Differential roles of factors IX and XI in murine placenta and hemostasis under conditions of low tissue factor. PMID:31935292
Integrated assessment of CDK1 upregulation in thyroid cancer. PMID:31934275
The clinicopathological significance of decreased miR-125b-5p in hepatocellular carcinoma: evidence based on RT-qPCR, microRNA-microarray, and microRNA-sequencing. PMID:31933718
Condensation of delta-1-piperideine-6-carboxylate with ortho-aminobenzaldehyde allows its simple, fast, and inexpensive quantification in the urine of patients with antiquitin deficiency. PMID:31930735
A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis. PMID:31928310
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression. PMID:31926610
Integration of IgA and IgG Autoantigens Improves Performance of Biomarker Panels for Early Diagnosis of Lung Cancer. PMID:31924693
Inflammasome expression is higher in ovarian tumors than in normal ovary. PMID:31923221
More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis. PMID:31921102
Live-Cell Assays for Cell Stress Responses Reveal New Patterns of Cell Signaling Caused by Mutations in Rhodopsin, α-Synuclein and TDP-43. PMID:31920544
GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. PMID:31919661
Mechanisms of tissue and cell-type specificity in heritable traits and diseases. PMID:31913361
Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association. PMID:31911620
Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains. PMID:31911579
Differential Expression in Testis and Liver Transcriptomes from Four Species of Peromyscus (Rodentia: Cricetidae). PMID:31909812
DDX3X Multifunctionally Modulates Tumor Progression and Serves as a Prognostic Indicator to Predict Cancer Outcomes. PMID:31906196
A Class II-Restricted CD8γ13 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection. PMID:31899500
TRPV6 as A Target for Cancer Therapy. PMID:31897233
Serum coiled-coil domain containing 25 protein as a potential screening/diagnostic biomarker for cholangiocarcinoma. PMID:31897206
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion. PMID:31896772
A re-evaluation of LINE-1 ORF2 expression in LNCaP prostate cancer cells. PMID:31890047
High-level integration of murine intestinal transcriptomics data highlights the importance of the complement system in mucosal homeostasis. PMID:31888466
Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin. PMID:31888244
Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System. PMID:31888217
Genetic variation drives seasonal onset of hibernation in the 13-lined ground squirrel. PMID:31886416
Longitudinal serum biomarker screening identifies malate dehydrogenase 2 as candidate prognostic biomarker for Duchenne muscular dystrophy. PMID:31881125
ABC Transporters at the Blood-Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas. PMID:31878061
Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer. PMID:31875161
Substrates, inhibitors, and probes of mammalian transglutaminase 2. PMID:31874171
Quantitative microscopy reveals dynamics and fate of clustered IRE1α. PMID:31871156
Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer. PMID:31871120
The STK16 inhibitor STK16-IN-1 inhibits non-adrenergic and non-neurogenic smooth muscle contractions in the human prostate and the human male detrusor. PMID:31867686
Characterization of Human Dosage-Sensitive Transcription Factor Genes. PMID:31867040
The Thyroid Hormone Receptor-RUNX2 Axis: A Novel Tumor Suppressive Pathway in Breast Cancer. PMID:31865591
Profiling of the plasma proteome across different stages of human heart failure. PMID:31862877
IL35 modulation altered survival, cytokine environment and histopathological consequences during malaria infection in mice. PMID:31856836
Upregulation of β3-adrenoceptors-a general marker of and protective mechanism against hypoxia? PMID:31853614
Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer. PMID:31852841
Transcriptome-Guided Drug Repositioning. PMID:31842375
Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children. PMID:31841498
PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis. PMID:31841108
Single-cell connectomic analysis of adult mammalian lungs. PMID:31840053
High-resolution chromosomal microarray analysis for copy-number variations in high-functioning autism reveals large aberration typical for intellectual disability. PMID:31838600
Pathogenic copy number variants are detected in a subset of patients with gastrointestinal malformations. PMID:31837127
LAMTOR5 raises abnormal initiation of O-glycosylation in breast cancer metastasis via modulating GALNT1 activity. PMID:31836847
Prostate-Derived ETS Factor (PDEF) Modulates Yes Associated Protein 1 (YAP1) in Prostate Cancer Cells: A Potential Cross-Talk between PDEF and Hippo Signaling. PMID:31835563
Loss of RAR-related orphan receptor alpha (RORα) selectively lowers docosahexaenoic acid in developing cerebellum. PMID:31835092
Proteomics: a powerful tool to study plant responses to biotic stress. PMID:31832077
Mapping human N-linked glycoproteins and glycosylation sites using mass spectrometry. PMID:31831916
Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers. PMID:31831737
Identification of microRNAs in skeletal muscle associated with lung cancer cachexia. PMID:31828982
Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry. PMID:31826992
Comprehensive Identification and Characterization of Human Secretome Based on Integrative Proteomic and Transcriptomic Data. PMID:31824949
Development of Immature CD4+CD8+T Cells Into Mature CD4+ T Cells Requires Alpha-1 Antitrypsin as Observed by Treatment in HIV-1 Infected and Uninfected Controls. PMID:31824943
Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer. PMID:31819186
The Fusion of Lipid and DNA Nanotechnology. PMID:31816934
Type I fatty acid synthase trapped in the octanoyl-bound state. PMID:31811668
In Vitro Expansion of Keratinocytes on Human Dermal Fibroblast-Derived Matrix Retains Their Stem-Like Characteristics. PMID:31811191
Ovarian cancer stem cells and targeted therapy. PMID:31810474
Proteogenomics of Colorectal Cancer Liver Metastases: Complementing Precision Oncology with Phenotypic Data. PMID:31805664
Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD. PMID:31805375
Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides. PMID:31802121
Structural basis for the dimerization of Gemin5 and its role in protein recruitment and translation control. PMID:31799608
Casein Kinase 1 Delta Regulates Cell Proliferation, Response to Chemotherapy and Migration in Human Ovarian Cancer Cells. PMID:31799185
Mass Cytometry Imaging for the Study of Human Diseases-Applications and Data Analysis Strategies. PMID:31798587
Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. PMID:31796108
Comparison of tumour and serum specific microRNA changes dissecting their role in pancreatic ductal adenocarcinoma: a meta-analysis. PMID:31795960
The Molecular Genetics of Gordon Syndrome. PMID:31795491
Integrative In Silico and In Vitro Transcriptomics Analysis Revealed Gene Expression Changes and Oncogenic Features of Normal Cholangiocytes after Chronic Alcohol Exposure. PMID:31795085
ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy. PMID:31794718
LASP1 promotes proliferation, metastasis, invasion in head and neck squamous cell carcinoma and through direct interaction with HSPA1A. PMID:31793711
JAK1 as a prognostic marker and its correlation with immune infiltrates in breast cancer. PMID:31790361
Sex-Based Analysis of De Novo Variants in Neurodevelopmental Disorders. PMID:31785789
The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data. PMID:31784565
Programmed DNA elimination of germline development genes in songbirds. PMID:31784533
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function. PMID:31784108
Analysis of the Human Protein Atlas Image Classification competition. PMID:31780840
Rapid affinity purification of intracellular organelles using a twin strep tag. PMID:31780580
Characterizing renal involvement in Hermansky-Pudlak Syndrome in a zebrafish model. PMID:31776394
Chemoenzymatic Semisynthesis of Proteins. PMID:31774265
An omics perspective on drug target discovery platforms. PMID:31774113
Update on KMT2B-Related Dystonia. PMID:31768667
Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease. PMID:31768427
Coauthor Country Affiliations in International Collaborative Research Funded by the US National Institutes of Health, 2009 to 2017. PMID:31755947
CACYBP Enhances Cytoplasmic Retention of P27Kip1 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation. PMID:31754404
Identifying gene function and module connections by the integration of multispecies expression compendia. PMID:31754022
Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location. PMID:31753726
In Situ Analysis Reveals That CFTR Is Expressed in Only a Small Minority of β-Cells in Normal Adult Human Pancreas. PMID:31748811
The Human Immunopeptidome Project: A Roadmap to Predict and Treat Immune Diseases. PMID:31744855
Phenotypic analysis combined with tandem mass tags (TMT) labeling reveal the heterogeneity of strawberry stolon buds. PMID:31744478
The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma. PMID:31739284
Is MYND Domain-Mediated Assembly of SMYD3 Complexes Involved in Calcium Dependent Signaling? PMID:31737645
Comprehensive investigation of key biomarkers and pathways in hepatitis B virus-related hepatocellular carcinoma. PMID:31737106
Expression of CCCTC-binding factor (CTCF) is linked to poor prognosis in prostate cancer. PMID:31736271
Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines. PMID:31733513
Structural basis of the strong cell-cell junction formed by cadherin-23. PMID:31729176
PCOSBase: a manually curated database of polycystic ovarian syndrome. PMID:31725861
The neXtProt knowledgebase in 2020: data, tools and usability improvements. PMID:31724716
Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production. PMID:31721422
Wnt-11 Expression Promotes Invasiveness and Correlates with Survival in Human Pancreatic Ductal Adeno Carcinoma. PMID:31718047
In Silico Study of Rett Syndrome Treatment-Related Genes, MECP2, CDKL5, and FOXG1, by Evolutionary Classification and Disordered Region Assessment. PMID:31717404
Proteomic analysis of eleven tissues in the Chinese giant salamander (Andrias davidianus). PMID:31712686
Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently. PMID:31712655
Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double-Stranded DNA Donors. PMID:31710422
Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis. PMID:31709908
Selective Histone Deacetylase 6 Inhibition Normalizes B Cell Activation and Germinal Center Formation in a Model of Systemic Lupus Erythematosus. PMID:31708928
Gene expression analysis of the cerebellar cortex in essential tremor. PMID:31707044
Megalin: A bridge connecting kidney, the renin-angiotensin system, and atherosclerosis. PMID:31707037
Identifying inaccuracies in gene expression estimates from unstranded RNA-seq data. PMID:31704962
ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress. PMID:31699981
Identification of key candidate genes and molecular pathways in white fat browning: an anti-obesity drug discovery based on computational biology. PMID:31699147
TCR Fingerprinting and Off-Target Peptide Identification. PMID:31695703
Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism. PMID:31693977
3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake. PMID:31692167
Aging results in accumulation of M1 and M2 hepatic macrophages and a differential response to gadolinium chloride. PMID:31691025
Co-regulation map of the human proteome enables identification of protein functions. PMID:31690884
PRADC1: a novel metabolic-responsive secretory protein that modulates physical activity and adiposity. PMID:31689374
CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth. PMID:31685994
ProTstab - predictor for cellular protein stability. PMID:31684883
MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis. PMID:31684860
Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications. PMID:31682939
GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies. PMID:31681577
2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels. PMID:31680972
An expanded mouse testis transcriptome and mass spectrometry defines novel proteins. PMID:31677600
Defining Transcriptional Signatures of Human Hair Follicle Cell States. PMID:31676413
Klf14 is an imprinted transcription factor that regulates placental growth. PMID:31675530
Preprotein signature for full susceptibility to the co-translational translocation inhibitor cyclotriazadisulfonamide. PMID:31675144
Covalently modified carboxyl side chains on cell surface leads to a novel method toward topology analysis of transmembrane proteins. PMID:31673029
Peptides of tetraspanin oncoprotein CD151 trigger active immunity against primary tumour and experimental lung metastasis. PMID:31668880
Focus on FKBP51: A molecular link between stress and metabolic disorders. PMID:31668388
The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly. PMID:31666358
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. PMID:31665640
Unraveling Triple-Negative Breast Cancer Tumor Microenvironment Heterogeneity: Towards an Optimized Treatment Approach. PMID:31665482
The Selective Progesterone Receptor Modulator Ulipristal Acetate Inhibits the Activity of the Glucocorticoid Receptor. PMID:31665442
Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells? PMID:31662755
Brain Region-Specific nAChR and Associated Protein Abundance Alterations Following Chronic Nicotine and/or Menthol Exposure. PMID:31657575
Combinatorial prediction of marker panels from single-cell transcriptomic data. PMID:31657111
PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance. PMID:31655611
MIC_Locator: a novel image-based protein subcellular location multi-label prediction model based on multi-scale monogenic signal representation and intensity encoding strategy. PMID:31655541
ACAT1 and Metabolism-Related Pathways Are Essential for the Progression of Clear Cell Renal Cell Carcinoma (ccRCC), as Determined by Co-expression Network Analysis. PMID:31649873
Oncomodulin: The Enigmatic Parvalbumin Protein. PMID:31649505
Increased CMTM6 can predict the clinical response to PD-1 inhibitors in non-small cell lung cancer patients. PMID:31646074
Gene4Denovo: an integrated database and analytic platform for de novo mutations in humans. PMID:31642496
Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers. PMID:31637211
Proteomics and Metabolomics in Kidney Disease, including Insights into Etiology, Treatment, and Prevention. PMID:31636087
Awakening dormant glycosyltransferases in CHO cells with CRISPRa. PMID:31631317
Selective loss of phosphoserine aminotransferase 1 (PSAT1) suppresses migration, invasion, and experimental metastasis in triple negative breast cancer. PMID:31630284
Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress. PMID:31625393
Sarcomeric myopathies associated with tremor: new insights and perspectives. PMID:31620961
Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease. PMID:31619995
Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines. PMID:31616026
Biological Network Approaches and Applications in Rare Disease Studies. PMID:31614842
Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72. PMID:31612854
Identification of a Nine-Gene Signature and Establishment of a Prognostic Nomogram Predicting Overall Survival of Pancreatic Cancer. PMID:31612115
Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells. PMID:31611601
Candidate Genes and MiRNAs Linked to the Inverse Relationship Between Cancer and Alzheimer's Disease: Insights From Data Mining and Enrichment Analysis. PMID:31608105
Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2. PMID:31605148
Genome-Scale Metabolic Modeling from Yeast to Human Cell Models of Complex Diseases: Latest Advances and Challenges. PMID:31602620
Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis. PMID:31602402
Diagnostic and prognostic biomarkers of Human Leukocyte Antigen complex for hepatitis B virus-related hepatocellular carcinoma. PMID:31602270
Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. PMID:31600961
Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. PMID:31599721
Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 3.0. PMID:31599596
snoDB: an interactive database of human snoRNA sequences, abundance and interactions. PMID:31598696
Uterine deficiency of high-mobility group box-1 (HMGB1) protein causes implantation defects and adverse pregnancy outcomes. PMID:31595043
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. PMID:31594949
Absolute Quantification of Apolipoproteins Following Treatment with Omega-3 Carboxylic Acids and Fenofibrate Using a High Precision Stable Isotope-labeled Recombinant Protein Fragments Based SRM Assay. PMID:31591263
Bringing Open Data to Whole Slide Imaging. PMID:31579322
Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel. PMID:31578243
High-Content Imaging for Large-Scale Detection of Low-Affinity Extracellular Protein Interactions. PMID:31578119
Highly heritable and functionally relevant breed differences in dog behaviour. PMID:31575369
Pyk2-dependent phosphorylation of LSR enhances localization of LSR and tricellulin at tricellular tight junctions. PMID:31574128
Pilot-Scale Study Of Human Plasma Proteomics Identifies ApoE And IL33 As Markers In Atopic Asthma. PMID:31571934
Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922. PMID:31569342
Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling. PMID:31568691
Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines. PMID:31565104
Portrait of Tissue-Specific Coexpression Networks of Noncoding RNAs (miRNA and lncRNA) and mRNAs in Normal Tissues. PMID:31565069
PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. PMID:31564549
Tissue-specific mouse mRNA isoform networks. PMID:31562339
Loss of myosin Vb promotes apical bulk endocytosis in neonatal enterocytes. PMID:31562230
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis. PMID:31558756
The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo. PMID:31555430
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling. PMID:31554934
Single-cell transcriptomic profiling of the aging mouse brain. PMID:31551601
Distinct Roles for BET Family Members in Estrogen Receptor α Enhancer Function and Gene Regulation in Breast Cancer Cells. PMID:31551256
SoyCSN: Soybean context-specific network analysis and prediction based on tissue-specific transcriptome data. PMID:31549018
d-amino Acids in Health and Disease: A Focus on Cancer. PMID:31547425
Diagnostic and prognostic values of C‑X‑C motif chemokine ligand 3 in patients with colon cancer. PMID:31545503
Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer. PMID:31545451
FOXN3 hyperglycemic risk allele and insulin sensitivity in humans. PMID:31543974
Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5. PMID:31539416
Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism. PMID:31537871
Characterisation and localisation of the endocannabinoid system components in the adult human testis. PMID:31537814
Dimethylguanidino Valerate: A Lifestyle-Related Metabolite Associated With Future Coronary Artery Disease and Cardiovascular Mortality. PMID:31533499
A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics. PMID:31533246
Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice. PMID:31526103
ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction. PMID:31525885
Dosage regulation, and variation in gene expression and copy number of human Y chromosome ampliconic genes. PMID:31525193
Unsupervised machine learning using an imaging mass spectrometry dataset automatically reassembles grey and white matter. PMID:31519997
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma. PMID:31519915
Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks. PMID:31515267
Control of human testis-specific gene expression. PMID:31514204
The association of integration patterns of human papilloma virus and single nucleotide polymorphisms on immune- or DNA repair-related genes in cervical cancer patients. PMID:31511581
Unexpected roles for ADH1 and SORD in catalyzing the final step of erythritol biosynthesis. PMID:31511322
A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic Approach. PMID:31511258
Hyperglycemia induces spermatogenic disruption via major pathways of diabetes pathogenesis. PMID:31506549
Aberrant Regulation of RAD51 Promotes Resistance of Neoadjuvant Endocrine Therapy in ER-positive Breast Cancer. PMID:31506496
Genome reading by the NF-κB transcription factors. PMID:31501881
HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. PMID:31500569
Analysis of CDKN1C in fetal growth restriction and pregnancy loss. PMID:31497289
Multi-view Subspace Clustering Analysis for Aggregating Multiple Heterogeneous Omics Data. PMID:31497031
High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification. PMID:31495056
A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. PMID:31494632
Neuromedin U: A Small Peptide in the Big World of Cancer. PMID:31492042
Copy number variants in lipid metabolism genes are associated with gallstones disease in men. PMID:31485028
The Coxsackievirus and Adenovirus Receptor, a Required Host Factor for Recovirus Infection, Is a Putative Enteric Calicivirus Receptor. PMID:31484750
Relative stabilities of wild-type and mutant glial fibrillary acidic protein in patients with Alexander disease. PMID:31484723
Inhibitory protein puts a lid on an epigenetic marker. PMID:31481771
Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome. PMID:31481669
Syndecan-Mediated Ligation of ECM Proteins Triggers Proliferative Arrest of Disseminated Tumor Cells. PMID:31481497
The Known and Potential Intersections of Rab-GTPases in Human Papillomavirus Infections. PMID:31475144
Dynamical Electrical Complexity Is Reduced during Neuronal Differentiation in Autism Spectrum Disorder. PMID:31474529
Minor intron splicing revisited: identification of new minor intron-containing genes and tissue-dependent retention and alternative splicing of minor introns. PMID:31470809
Mesencephalic Astrocyte-Derived Neurotrophic Factor Inhibits Liver Cancer Through Small Ubiquitin-Related Modifier (SUMO)ylation-Related Suppression of NF-κB/Snail Signaling Pathway and Epithelial-Mesenchymal Transition. PMID:31469428
DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases. PMID:31467668
Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer. PMID:31467540
Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-β fibrils. PMID:31467325
Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2. PMID:31466081
Stoichioproteomics reveal oxygen usage bias, key proteins and pathways in glioma. PMID:31464612
The effects of di-butyl phthalate exposure from medications on human sperm RNA among men. PMID:31455814
Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy. PMID:31452838
Screening of potential biomarkers in hepatitis C virus-induced hepatocellular carcinoma using bioinformatic analysis. PMID:31452738
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program. PMID:31451708
Divide and conquer: two stem cell populations in squamous epithelia, reserves and the active duty forces. PMID:31451683
Targeting Immunophenotypic Markers on Leukemic Stem Cells: How Lessons from Current Approaches and Advances in the Leukemia Stem Cell (LSC) Model Can Inform Better Strategies for Treating Acute Myeloid Leukemia (AML). PMID:31451539
Mechanism and Regulation of Gasdermin-Mediated Cell Death. PMID:31451512
Construction and Investigation of a lncRNA-Associated ceRNA Regulatory Network in Cholangiocarcinoma. PMID:31448221
Target Genes of Autism Risk Loci in Brain Frontal Cortex. PMID:31447881
Expression Levels of 4 Genes in Colon Tissue Might Be Used to Predict Which Patients Will Enter Endoscopic Remission After Vedolizumab Therapy for Inflammatory Bowel Diseases. PMID:31446181
A phase I study of enfortumab vedotin in Japanese patients with locally advanced or metastatic urothelial carcinoma. PMID:31444589
Differential gene expression and gene-set enrichment analysis in Caco-2 monolayers during a 30-day timeline with Dexamethasone exposure. PMID:31438773
Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination. PMID:31437751
Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice Phenotype Characterization. PMID:31431000
Progress on Identifying and Characterizing the Human Proteome: 2019 Metrics from the HUPO Human Proteome Project. PMID:31430157
Localization-specific distributions of protein pI in human proteome are governed by local pH and membrane charge. PMID:31429701
Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues. PMID:31427819
Rho GTPases in cancer: friend or foe? PMID:31427738
KCNMA1-linked channelopathy. PMID:31427379
Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion. PMID:31427285
Cdh4 Down-Regulation Impairs in Vivo Infiltration and Malignancy in Patients Derived Glioblastoma Cells. PMID:31426573
Deciphering GRINA/Lifeguard1: Nuclear Location, Ca2+ Homeostasis and Vesicle Transport. PMID:31426446
Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism. PMID:31422917
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. PMID:31422913
Loss of microfibril-associated protein 5 (MFAP5) expression in colon cancer stroma. PMID:31422503
Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling. PMID:31421261
Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic Modeling. PMID:31417867
A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. PMID:31417100
The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation. PMID:31409643
The analysis of risk factors for diabetic nephropathy progression and the construction of a prognostic database for chronic kidney diseases. PMID:31409386
Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses. PMID:31408441
Furin-mediated protein processing in infectious diseases and cancer. PMID:31406574
MicroRNA let-7-TGFBR3 signalling regulates cardiomyocyte apoptosis after infarction. PMID:31401194
A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination. PMID:31399485
Targeting CDK9 for treatment of colorectal cancer. PMID:31398271
Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs. PMID:31396219
DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease. PMID:31387232
Adaptation to Extreme Environments in an Admixed Human Population from the Atacama Desert. PMID:31384924
Stoichiogenomics reveal oxygen usage bias, key proteins and pathways associated with stomach cancer. PMID:31383879
The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells. PMID:31381610
Computational Analysis of HLA-presentation of Non-synonymous Recipient Mismatches Indicates Effect on the Risk of Chronic Graft-vs.-Host Disease After Allogeneic HSCT. PMID:31379830
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5. PMID:31379819
Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells. PMID:31379806
Molecular Systems Biology of Neurodevelopmental Disorders, Rett Syndrome as an Archetype. PMID:31379529
Mapping Interactions of Microbial Metabolites with Human G-Protein-Coupled Receptors. PMID:31378678
A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology. PMID:31378672
Exploring the molecular basis of neuronal excitability in a vocal learner. PMID:31375088
Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A. PMID:31374199
The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour. PMID:31371726
Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma. PMID:31369399
Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions. PMID:31367837
Relating evolutionary selection and mutant clonal dynamics in normal epithelia. PMID:31362624
Comprehensive analysis of differentially expressed circRNAs revealed a ceRNA network in pancreatic ductaladenocarcinoma. PMID:31360192
T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance. PMID:31355495
Promoter conservation in HDACs points to functional implications. PMID:31351464
The genome of the live-bearing fish Heterandria formosa implicates a role of conserved vertebrate genes in the evolution of placental fish. PMID:31349784
Decreased expression of SLC16A12 mRNA predicts poor prognosis of patients with clear cell renal cell carcinoma. PMID:31348313
Exosome release and cargo in Down syndrome. PMID:31347291
Intrinsic expression of viperin regulates thermogenesis in adipose tissues. PMID:31341090
The diagnostic and prognostic role of RhoA in hepatocellular carcinoma. PMID:31339860
Chemotactic Ligands that Activate G-Protein-Coupled Formylpeptide Receptors. PMID:31336833
Upregulation of nucleoprotein AHNAK is associated with poor outcome of pancreatic ductal adenocarcinoma prognosis via mediating epithelial-mesenchymal transition. PMID:31333803
Gene Therapy Corrects Brain and Behavioral Pathologies in CLN6-Batten Disease. PMID:31331814
AKAP6 and phospholamban colocalize and interact in HEK-293T cells and primary murine cardiomyocytes. PMID:31325238
Estimating dispensable content in the human interactome. PMID:31324802
Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer. PMID:31324208
Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis. PMID:31324198
Assessing key decisions for transcriptomic data integration in biochemical networks. PMID:31323017
Transcriptional control and transcriptomic analysis of lipid metabolism in skin barrier formation and atopic dermatitis (AD). PMID:31322970
Identification of a missense variant in CLDN2 in obstructive azoospermia. PMID:31320686
Computational Drug Screening Identifies Compounds Targeting Renal Age-associated Molecular Profiles. PMID:31316728
The Warburg Effect Is Associated With Tumor Aggressiveness in Testicular Germ Cell Tumors. PMID:31316469
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. PMID:31316208
Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis. PMID:31316008
Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production. PMID:31311960
Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells. PMID:31311882
Identification of novel genes associated with a poor prognosis in pancreatic ductal adenocarcinoma via a bioinformatics analysis. PMID:31311829
Exploring the Molecular Mechanism of the Drug-Treated Breast Cancer Based on Gene Expression Microarray. PMID:31311202
Clinical update on head and neck cancer: molecular biology and ongoing challenges. PMID:31308358
Small-protein Enrichment Assay Enables the Rapid, Unbiased Analysis of Over 100 Low Abundance Factors from Human Plasma. PMID:31308252
Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer. PMID:31307411
Benchmarking subcellular localization and variant tolerance predictors on membrane proteins. PMID:31307390
Identification and analysis of genes associated with head and neck squamous cell carcinoma by integrated bioinformatics methods. PMID:31304688
Cardiac tissue engineering: state-of-the-art methods and outlook. PMID:31297148
Retention of paternal DNA methylome in the developing zebrafish germline. PMID:31296860
A human liver cell atlas reveals heterogeneity and epithelial progenitors. PMID:31292543
Landscape of innate immune system transcriptome and acute T cell-mediated rejection of human kidney allografts. PMID:31292297
Tubulin glutamylation: a skeleton key for neurodegenerative diseases. PMID:31290441
The heterogeneity and complexity of Cannabis extracts as antitumor agents. PMID:31289609
Mapping the protein-protein and genetic interactions of cancer to guide precision medicine. PMID:31288129
Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility. PMID:31285581
Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes. PMID:31282863
Genome-wide functional association networks: background, data & state-of-the-art resources. PMID:31281921
CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. PMID:31281901
Co-expression network analysis identified candidate biomarkers in association with progression and prognosis of breast cancer. PMID:31280346
Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study. PMID:31277479
Large HERCs Function as Tumor Suppressors. PMID:31275856
Milk proteome from in silico data aggregation allows the identification of putative biomarkers of negative energy balance in dairy cows. PMID:31273261
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants. PMID:31273118
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. PMID:31268602
Integrating proteomics and transcriptomics for the identification of potential targets in early colorectal cancer. PMID:31268166
In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes. PMID:31265809
Whole-exome sequencing of ovarian cancer families uncovers putative predisposition genes. PMID:31265121
Genome-wide association analysis uncovers variants for reproductive variation across dog breeds and links to domestication. PMID:31263560
Germline BRCA1 Mutation Detected in a Multiple Endocrine Neoplasia Type 2 Case With RET Codon 634 Mutation. PMID:31263477
Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14. PMID:31261654
Transcriptomes of antigen presenting cells in human thymus. PMID:31261375
Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells. PMID:31260037
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation. PMID:31253574
Quantitative Systems Pharmacology Model of a Masked, Tumor-Activated Antibody. PMID:31250966
Best practices and benchmarks for intact protein analysis for top-down mass spectrometry. PMID:31249407
A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys. PMID:31249312
Multi-omics Biomarker Pipeline Reveals Elevated Levels of Protein-glutamine Gamma-glutamyltransferase 4 in Seminal Plasma of Prostate Cancer Patients. PMID:31249104
Estimation of allele-specific fitness effects across human protein-coding sequences and implications for disease. PMID:31249063
Leveraging the Role of the Metastatic Associated Protein Anterior Gradient Homologue 2 in Unfolded Protein Degradation: A Novel Therapeutic Biomarker for Cancer. PMID:31247903
Biological Pathway Specificity in the Cell-Does Molecular Diversity Matter? PMID:31245864
A Circulating Tumor Cell-RNA Assay for Assessment of Androgen Receptor Signaling Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer. PMID:31244925
Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'. PMID:31244471
Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics. PMID:31243108
Parent-of-origin-specific allelic expression in the human placenta is limited to established imprinted loci and it is stably maintained across pregnancy. PMID:31242935
Proteolytic Rafts for Improving Intraparenchymal Migration of Minimally Invasively Administered Hydrogel-Embedded Stem Cells. PMID:31238564
The roles of the human SETMAR (Metnase) protein in illegitimate DNA recombination and non-homologous end joining repair. PMID:31238295
Unified single-cell analysis of testis gene regulation and pathology in five mouse strains. PMID:31237565
Comprehensive evaluation of FKBP10 expression and its prognostic potential in gastric cancer. PMID:31233188
Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults. PMID:31231205
Characterization of Contractile Proteins from Skeletal Muscle Using Gel-Based Top-Down Proteomics. PMID:31226838
The role of hydrophobic matching on transmembrane helix packing in cells. PMID:31225439
CNBP controls transcription by unfolding DNA G-quadruplex structures. PMID:31219592
Gene Information eXtension (GIX): effortless retrieval of gene product information on any website. PMID:31217594
Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease. PMID:31217356
HNF4α and CDX2 Regulate Intestinal YAP1 Promoter Activity. PMID:31216773
Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective. PMID:31216675
Consequences of Y chromosome microdeletions beyond male infertility. PMID:31214882
The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease. PMID:31214167
Signatures of Recent Positive Selection in Enhancers Across 41 Human Tissues. PMID:31213516
Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium. PMID:31209240
Genetic Mutations Underlying Phenotypic Plasticity in Basosquamous Carcinoma. PMID:31207229
Development of a predictive model for stromal content in prostate cancer samples to improve signature performance. PMID:31206668
The p52 isoform of SHC1 is a key driver of breast cancer initiation. PMID:31202267
Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia. PMID:31200555
Current status and applications of genome-scale metabolic models. PMID:31196170
Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial-mesenchymal transition. PMID:31196164
LncRRIsearch: A Web Server for lncRNA-RNA Interaction Prediction Integrated With Tissue-Specific Expression and Subcellular Localization Data. PMID:31191601
Molecular Mechanisms by Which Selenoprotein K Regulates Immunity and Cancer. PMID:31187393
Indoleamine 2,3-dioxygenase and ischemic heart disease: a Mendelian Randomization study. PMID:31186442
Dynamic genome-scale cell-specific metabolic models reveal novel inter-cellular and intra-cellular metabolic communications during ovarian follicle development. PMID:31182013
Spliced X-box Binding Protein 1 Stimulates Adaptive Growth Through Activation of mTOR. PMID:31177839
A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation. PMID:31172184
HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis. PMID:31163988
Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities. PMID:31160710
Bridging the gap between reference and real transcriptomes. PMID:31159855
Small molecule target identification using photo-affinity chromatography. PMID:31155061
Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma. PMID:31154438
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. PMID:31149896
Eleven genes associated with progression and prognosis of endometrial cancer (EC) identified by comprehensive bioinformatics analysis. PMID:31139013
Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C. PMID:31138701
Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies. PMID:31130731
The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination. PMID:31127291
Exploiting Interdata Relationships in Next-generation Proteomics Analysis. PMID:31126983
Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway. PMID:31118659
Angiotensin II-mediated MYH9 downregulation causes structural and functional podocyte injury in diabetic kidney disease. PMID:31118506
Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development. PMID:31116975
ResponseNet v.3: revealing signaling and regulatory pathways connecting your proteins and genes across human tissues. PMID:31114913
Increased expression of TMED2 is an unfavorable prognostic factor in patients with breast cancer. PMID:31114314
RIP2 promotes FcγR-mediated reactive oxygen species production. PMID:31113864
A novel conserved family of Macro-like domains-putative new players in ADP-ribosylation signaling. PMID:31106069
Secretomes from metastatic breast cancer cells, enriched for a prognostically unfavorable LCN2 axis, induce anti-inflammatory MSC actions and a tumor-supportive premetastatic lung. PMID:31105883
Expression profile and functional role of S100A14 in human cancer. PMID:31105881
Gi/o-Protein Coupled Receptors in the Aging Brain. PMID:31105551
Fatty Acid Signaling Mechanisms in Neural Cells: Fatty Acid Receptors. PMID:31105530
Meiotic gene activation in somatic and germ cell tumours. PMID:31102330
Expression of Glypican 3 is an Independent Prognostic Biomarker in Primary Gastro-Esophageal Adenocarcinoma and Corresponding Serum Exosomes. PMID:31100935
Silencing of Aberrant Secretory Protein Expression by Disease-Associated Mutations. PMID:31100385
The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells. PMID:31097295
Profiling Autoantibodies against Salivary Proteins in Sicca Conditions. PMID:31095438
Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling. PMID:31087223
PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. PMID:31086175
c-Met as a new marker of cellular senescence. PMID:31085799
Genome-wide analyses of psychological resilience in U.S. Army soldiers. PMID:31081985
The clinical spectrum of the congenital myasthenic syndrome resulting from COL13A1 mutations. PMID:31081514
Pseudomonas aeruginosa-derived pyocyanin reduces adipocyte differentiation, body weight, and fat mass as mechanisms contributing to septic cachexia. PMID:31078726
Tissue-specific genes as an underutilized resource in drug discovery. PMID:31076736
Cryo-Electron Tomography and Proteomics studies of centrosomes from differentiated quiescent thymocytes. PMID:31076588
Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients. PMID:31070306
Metabolic enzymes expressed by cancer cells impact the immune infiltrate. PMID:31069148
Large-scale in-silico identification of a tumor-specific antigen pool for targeted immunotherapy in triple-negative breast cancer. PMID:31069014
Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells. PMID:31068932
g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). PMID:31066453
Epigenome-wide DNA methylation in placentas from preterm infants: association with maternal socioeconomic status. PMID:31062658
Targeting the High-Mobility Group Box 3 Protein Sensitizes Chemoresistant Ovarian Cancer Cells to Cisplatin. PMID:31061066
FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane. PMID:31056421
The SUMO-Specific Protease Senp2 Regulates SUMOylation, Expression and Function of Human Organic Anion Transporter 3. PMID:31054272
Actin-tropomyosin distribution in non-muscle cells. PMID:31054005
Characterization of CNPY5 and its family members. PMID:31050855
Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function. PMID:31048406
MetAP2 inhibition increases energy expenditure through direct action on brown adipocytes. PMID:31048375
Divergent effects of vitamins K1 and K2 on triple negative breast cancer cells. PMID:31040920
A nanobody-based molecular toolkit provides new mechanistic insight into clathrin-coat initiation. PMID:31038455
Soluble Heparin Binding Epidermal Growth Factor-Like Growth Factor Is a Regulator of GALGT2 Expression and GALGT2-Dependent Muscle and Neuromuscular Phenotypes. PMID:31036568
Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling. PMID:31035605
Network Medicine in the Age of Biomedical Big Data. PMID:31031797
Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals. PMID:31031010
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. PMID:31028174
The Fate of Glutamine in Human Metabolism. The Interplay with Glucose in Proliferating Cells. PMID:31027329
PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel. PMID:31023925
Strategies for Network GWAS Evaluated Using Classroom Crowd Science. PMID:31022372
A Bioinformatics View of Glycan⁻Virus Interactions. PMID:31018588
Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition. PMID:31018575
Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis. PMID:31018140
YAP-independent mechanotransduction drives breast cancer progression. PMID:31015465
eIF4G2 balances its own mRNA translation via a PCBP2-based feedback loop. PMID:31010886
Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer. PMID:31003445
Transcriptome Analysis Revealed a Highly Connected Gene Module Associated With Cirrhosis to Hepatocellular Carcinoma Development. PMID:31001331
Targeting Tumor Vascular CD99 Inhibits Tumor Growth. PMID:31001265
Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask). PMID:30995798
Crystal structure of human RIOK2 bound to a specific inhibitor. PMID:30991936
Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability. PMID:30990168
Myometrial Transcriptional Signatures of Human Parturition. PMID:30988671
Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates. PMID:30988006
IFITM3: How genetics influence influenza infection demographically. PMID:30987701
Proteomic Analysis Implicates Vimentin in Glioblastoma Cell Migration. PMID:30987208
Increasing consensus of context-specific metabolic models by integrating data-inferred cell functions. PMID:30986217
Quantitative Proteomic Analysis of Human Seminal Plasma from Normozoospermic and Asthenozoospermic Individuals. PMID:30984777
Cell migration and proliferation are regulated by miR-26a in colorectal cancer via the PTEN-AKT axis. PMID:30983885
Tspan8 is expressed in breast cancer and regulates E-cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles. PMID:30982971
CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids. PMID:30982469
Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies. PMID:30974124
In silico Characterization of Human Prion-Like Proteins: Beyond Neurological Diseases. PMID:30971948
Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner. PMID:30971297
Systems Biology Reveals NR2F6 and TGFB1 as Key Regulators of Feed Efficiency in Beef Cattle. PMID:30967894
Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor. PMID:30965276
Analysis of the role of the Hippo pathway in cancer. PMID:30961610
Androgen deprivation therapy promotes an obesity-like microenvironment in periprostatic fat. PMID:30959474
In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta. PMID:30958262
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma. PMID:30957641
Proteomic studies of bone and skeletal health outcomes. PMID:30954730
Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects. PMID:30952858
Prognostic role of cyclin D2/D3 in multiple human malignant neoplasms: A systematic review and meta-analysis. PMID:30950241
Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory. PMID:30948719
Genome-wide Analysis of Common Copy Number Variation and Epithelial Ovarian Cancer Risk. PMID:30948450
Inflammation: A key process in skin tumorigenesis. PMID:30944600
Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles. PMID:30943406
BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers. PMID:30941229
Fetal lung C4BPA induces p100 processing in human placenta. PMID:30940885
The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. PMID:30930166
Evaluation and Interpretation of Transcriptome Data Underlying Heterogeneous Chronic Obstructive Pulmonary Disease. PMID:30929403
EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma. PMID:30923826
Serum endostatin levels are associated with diffusion capacity and with tuberous sclerosis- associated lymphangioleiomyomatosis. PMID:30922357
The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population. PMID:30920136
Multifactorial Contribution of Notch Signaling in Head and Neck Squamous Cell Carcinoma. PMID:30917608
Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator. PMID:30916349
Melanoma-Induced Reprogramming of Schwann Cell Signaling Aids Tumor Growth. PMID:30914431
Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients. PMID:30914425
Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis. PMID:30906868
Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1. PMID:30906261
Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning. PMID:30905848
Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage. PMID:30900988
Evolutionary and functional implications of 3' untranslated region length of mRNAs by comprehensive investigation among four taxonomically diverse metazoan species. PMID:30900191
Diagnostic and prognostic value of mRNA expression of phospholipase C β family genes in hepatitis B virus‑associated hepatocellular carcinoma. PMID:30896816
Comprehensive Analysis of Individual Variation in the Urinary Proteome Revealed Significant Gender Differences. PMID:30894400
Proteomic Analysis of Human Plasma during Intermittent Fasting. PMID:30892045
Hexosamine Biosynthetic Pathway and Glycosylation Regulate Cell Migration in Melanoma Cells. PMID:30891426
Identifying and exploiting gene-pathway interactions from RNA-seq data for binary phenotype. PMID:30890140
Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. PMID:30889382
Primate piRNA Cluster Evolution Suggests Limited Relevance of Pseudogenes in piRNA-Mediated Gene Regulation. PMID:30888404
Identification of Important Effector Proteins in the FOXJ1 Transcriptional Network Associated With Ciliogenesis and Ciliary Function. PMID:30881373
Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer. PMID:30875794
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy. PMID:30873179
Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis. PMID:30872636
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma. PMID:30872592
Regulation of proline-directed kinases and the trans-histone code H3K9me3/H4K20me3 during human myogenesis. PMID:30872405
netDx: interpretable patient classification using integrated patient similarity networks. PMID:30872331
β3 -Adrenoceptors in the normal and diseased urinary bladder-What are the open questions? PMID:30868554
Post-transcriptional regulatory patterns revealed by protein-RNA interactions. PMID:30867517
Aberrant DOCK2, GRASP, HIF3A and PKFP Hypermethylation has Potential as a Prognostic Biomarker for Prostate Cancer. PMID:30866497
A novel Microproteomic Approach Using Laser Capture Microdissection to Study Cellular Protrusions. PMID:30866487
A systematic review and standardized clinical validity assessment of male infertility genes. PMID:30865283
LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3. PMID:30858559
The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1. PMID:30858459
UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation. PMID:30858178
Clinical Stratification of High-Grade Ovarian Serous Carcinoma Using a Panel of Six Biomarkers. PMID:30857227
A network-based approach to identify DNA methylation and its involved molecular pathways in testicular germ cell tumors. PMID:30854095
Emerging drug development technologies targeting ubiquitination for cancer therapeutics. PMID:30851297
Increased LGALS3 expression independently predicts shorter overall survival in patients with the proneural subtype of glioblastoma. PMID:30848102
Genome-wide meta-analysis identifies novel loci associated with free triiodothyronine and thyroid-stimulating hormone. PMID:30843173
S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. PMID:30842656
HER2 Directed Antibody-Drug-Conjugates beyond T-DM1 in Breast Cancer. PMID:30841523
A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome. PMID:30840886
Geometric characterisation of disease modules. PMID:30839777
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion. PMID:30836712
Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle. PMID:30835510
Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion. PMID:30835257
Functional Modules of the Proteostasis Network. PMID:30833457
A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing. PMID:30829570
Regulation of Microbiota by Vitamin D Receptor: A Nuclear Weapon in Metabolic Diseases. PMID:30828578
Isoform-specific GSK3A activity is negatively correlated with human sperm motility. PMID:30824926
Selecting variants of unknown significance through network-based gene-association significantly improves risk prediction for disease-control cohorts. PMID:30824863
Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors. PMID:30823893
COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis. PMID:30819896
Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard. PMID:30819892
Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia. PMID:30819197
Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail. PMID:30818851
In silico analysis identified miRNA‑based therapeutic agents against glioblastoma multiforme. PMID:30816530
Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior. PMID:30814913
MicroRNAs from saliva of anopheline mosquitoes mimic human endogenous miRNAs and may contribute to vector-host-pathogen interactions. PMID:30814633
Comparative analyses of sperm DNA methylomes among human, mouse and cattle provide insights into epigenomic evolution and complex traits. PMID:30810461
Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells. PMID:30810435
NOD1: An Interface Between Innate Immunity and Insulin Resistance. PMID:30807635
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. PMID:30804560
Proteomic Maps of Human Gastrointestinal Stromal Tumor Subgroups. PMID:30804049
UBTD1 is a mechano-regulator controlling cancer aggressiveness. PMID:30804013
Cardiac β3 -adrenoceptors-A role in human pathophysiology? PMID:30801686
Clinical Transcriptome Sequencing Confirms Activation of a Cryptic Splice Site in Suspected SYNGAP1-Related Disorder. PMID:30800045
The Emerging World of TCR-T Cell Trials Against Cancer: A Systematic Review. PMID:30798772
Predicted secreted protein analysis reveals synaptogenic function of Clstn3 during WAT browning and BAT activation in mice. PMID:30796355
Genomic landscape of a metastatic malignant proliferating tricholemmal tumor and its response to PI3K inhibition. PMID:30793038
Down-regulation of FZD3 receptor suppresses growth and metastasis of human melanoma independently of canonical WNT signaling. PMID:30792348
Human colon organoids reveal distinct physiologic and oncogenic Wnt responses. PMID:30792186
Comprehensive clinical implications of homeobox A10 in 3,199 cases of non-small cell lung cancer tissue samples combining qRT-PCR, RNA sequencing and microarray data. PMID:30787969
MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon. PMID:30784582
Cellular Compartmentation and the Redox/Nonredox Functions of NAD. PMID:30784294
Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer. PMID:30781493
Molecular crypsis by pathogenic fungi using human factor H. A numerical model. PMID:30779817
Towards a data-integrated cell. PMID:30778056
Quantification and discovery of sequence determinants of protein-per-mRNA amount in 29 human tissues. PMID:30777893
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues. PMID:30777892
A Cholesterol Analog Induces an Oligomeric Reorganization of VDAC. PMID:30777305
Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas. PMID:30777055
The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation. PMID:30770239
Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring. PMID:30768568
Flotillin1 promotes EMT of human small cell lung cancer via TGF-β signaling pathway. PMID:30766750
MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma. PMID:30765601
Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. PMID:30760538
PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq. PMID:30759402
Survival in a bad neighborhood: pancreatic islets in cystic fibrosis. PMID:30759072
Identification of special key genes for alcohol-related hepatocellular carcinoma through bioinformatic analysis. PMID:30755830
Eradication of glioblastoma by immuno-virotherapy with a retargeted oncolytic HSV in a preclinical model. PMID:30755732
CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3. PMID:30755730
Integrated bioinformatics analysis of key genes involved in progress of colon cancer. PMID:30746900
SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro. PMID:30744170
Histamine N-Methyltransferase in the Brain. PMID:30744146
Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma. PMID:30736807
Predicting clinically promising therapeutic hypotheses using tensor factorization. PMID:30736745
Proteomic Atlas of the Human Brain in Alzheimer's Disease. PMID:30735395
The antimicrobial protein S100A12 identified as a potential autoantigen in a subgroup of atopic dermatitis patients. PMID:30728947
WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial-mesenchymal transition. PMID:30723155
PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling. PMID:30718277
Conserved regulation of RNA processing in somatic cell reprogramming. PMID:30704403
Heart failure in cancer: role of checkpoint inhibitors. PMID:30701100
Mass Spectrometry-based Absolute Quantification of 20S Proteasome Status for Controlled Ex-vivo Expansion of Human Adipose-derived Mesenchymal Stromal/Stem Cells. PMID:30700495
Detecting Secretory Proteins by Acoustic Droplet Ejection in Multiplexed High-Throughput Applications. PMID:30699290
Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion. PMID:30698726
Spatial Principles of Chromatin Architecture Associated With Organ-Specific Gene Regulation. PMID:30697540
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules. PMID:30693281
Cadherin 11 Inhibition Downregulates β-catenin, Deactivates the Canonical WNT Signalling Pathway and Suppresses the Cancer Stem Cell-Like Phenotype of Triple Negative Breast Cancer. PMID:30691241
Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4. PMID:30691220
Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. PMID:30685239
Are we listening to everything the PARK genes are telling us? PMID:30680728
NKL homeobox gene NKX2-2 is aberrantly expressed in Hodgkin lymphoma. PMID:30680064
A Retrospective Analysis of the Cartilage Kunitz Protease Inhibitory Proteins Identifies These as Members of the Inter-α-Trypsin Inhibitor Superfamily with Potential Roles in the Protection of the Articulatory Surface. PMID:30678366
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation. PMID:30674441
Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer. PMID:30670910
Gut microbiota profiling with differential tolerance against the reduced dietary fibre level in rabbit. PMID:30670754
PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights. PMID:30668673
miR663a‑TTC22V1 axis inhibits colon cancer metastasis. PMID:30664167
Mucosal IL13RA2 expression predicts nonresponse to anti-TNF therapy in Crohn's disease. PMID:30663072
Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression. PMID:30661928
Spatial proteomics: a powerful discovery tool for cell biology. PMID:30659282
Combining LOPIT with differential ultracentrifugation for high-resolution spatial proteomics. PMID:30659192
VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site. PMID:30657523
The RANK-RANKL axis: an opportunity for drug repurposing in cancer? PMID:30656607
RiboTag translatomic profiling of Drosophila oenocytes under aging and induced oxidative stress. PMID:30651069
Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis. PMID:30649494
Large-scale analysis of human gene expression variability associates highly variable drug targets with lower drug effectiveness and safety. PMID:30649201
Elucidation of the functional roles of the Q and I motifs in the human chromatin-remodeling enzyme BRG1. PMID:30647132
Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation. PMID:30639098
Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target. PMID:30635167
Leveraging Multilayered "Omics" Data for Atopic Dermatitis: A Road Map to Precision Medicine. PMID:30631320
Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis. PMID:30629778
Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy. PMID:30628708
Organoid single cell profiling identifies a transcriptional signature of glomerular disease. PMID:30626756
Variations in HPV function are associated with survival in squamous cell carcinoma. PMID:30626753
Cancer Connectors: Connexins, Gap Junctions, and Communication. PMID:30622930
Wireless Electrochemical Detection on a Microfluidic Compact Disc (CD) and Evaluation of Redox-Amplification during Flow. PMID:30621031
The Importance of Biologic Knowledge and Gene Expression Context for Genomic Data Interpretation. PMID:30619486
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. PMID:30617275
Systems-based approaches for investigation of inter-tissue communication. PMID:30617149
Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis. PMID:30606699
The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens. PMID:30606230
Clinical significance and biological role of cancer-derived Type I collagen in lung and esophageal cancers. PMID:30604926
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies. PMID:30604766
A region-resolved mucosa proteome of the human stomach. PMID:30604760
Alterations in sialic-acid O-acetylation glycoforms during murine erythrocyte development. PMID:30597004
miR‑675 promotes colorectal cancer cell growth dependent on tumor suppressor DMTF1. PMID:30592263
Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus. PMID:30591584
The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass. PMID:30588560
Oncogenic Role of Tumor Necrosis Factor α-Induced Protein 8 (TNFAIP8). PMID:30586922
Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community. PMID:30580566
Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients. PMID:30578919
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. PMID:30578418
A locus on chromosome 5 shows African ancestry-limited association with alloimmunization in sickle cell disease. PMID:30578281
Novel circular RNA circNF1 acts as a molecular sponge, promoting gastric cancer by absorbing miR-16. PMID:30576282
Calmodulinopathy: A Novel, Life-Threatening Clinical Entity Affecting the Young. PMID:30574507
Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells. PMID:30573509
Proteomic Analysis of the Human Anterior Pituitary Gland. PMID:30571610
Cell Hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics. PMID:30567574
NAD Metabolome Analysis in Human Cells Using ¹H NMR Spectroscopy. PMID:30563212
Diagnosing rare diseases after the exome. PMID:30559314
Intrinsic Dynamics of a Human Gene Reveal the Basis of Expression Heterogeneity. PMID:30554876
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis. PMID:30554520
How many cadherins do human endothelial cells express? PMID:30552441
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. PMID:30552067
B cells in esophago-gastric adenocarcinoma are highly differentiated, organize in tertiary lymphoid structures and produce tumor-specific antibodies. PMID:30546950
Targeted Delivery of TNF Potentiates the Antibody-Dependent Cell-Mediated Cytotoxicity of an Anti-Melanoma Immunoglobulin. PMID:30543899
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. PMID:30542056
Analysis of 3D genomic interactions identifies candidate host genes that transposable elements potentially regulate. PMID:30541598
PopViz: a webserver for visualizing minor allele frequencies and damage prediction scores of human genetic variations. PMID:30535305
Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease. PMID:30533169
Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition. PMID:30532030
Loss of Ca2+/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease. PMID:30525042
Borders of Cis-Regulatory DNA Sequences Preferentially Harbor the Divergent Transcription Factor Binding Motifs in the Human Genome. PMID:30524473
Proteome-wide Tyrosine Phosphorylation Analysis Reveals Dysregulated Signaling Pathways in Ovarian Tumors. PMID:30523211
The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland. PMID:30520817
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. PMID:30518876
Stable-protein Pair Analysis as A Novel Strategy to Identify Proteomic Signatures: Application To Seminal Plasma From Infertile Patients. PMID:30518674
Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing. PMID:30514914
The Role of Cystinosin in the Intermediary Thiol Metabolism and Redox Homeostasis in Kidney Proximal Tubular Cells. PMID:30513914
Molecular characterization and biomarker identification in colorectal cancer: Toward realization of the precision medicine dream. PMID:30510457
Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin. PMID:30508377
The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes. PMID:30504233
2C-BioID: An Advanced Two Component BioID System for Precision Mapping of Protein Interactomes. PMID:30500481
Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems. PMID:30487642
Novel in Vitro Method Reveals Drugs That Inhibit Organic Solute Transporter Alpha/Beta (OSTα/β). PMID:30481467
Identification of RPL5 and RPL10 as novel diagnostic biomarkers of Atypical teratoid/rhabdoid tumors. PMID:30479569
Prostate-specific markers to identify rare prostate cancer cells in liquid biopsies. PMID:30479377
Pooled extracellular receptor-ligand interaction screening using CRISPR activation. PMID:30477585
Frailty Index associates with GRIN2B in two representative samples from the United States and the United Kingdom. PMID:30475886
FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer. PMID:30475207
Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma. PMID:30471425
A HS6ST2 gene variant associated with X-linked intellectual disability and severe myopia in two male twins. PMID:30471091
Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer. PMID:30470719
Protocadherin-1 is essential for cell entry by New World hantaviruses. PMID:30464266
Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium. PMID:30464253
Integration of transcriptome and proteome profiles in glioblastoma: looking for the missing link. PMID:30463513
Tissue-Based Mapping of the Fathead Minnow (Pimephales promelas) Transcriptome and Proteome. PMID:30459712
Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson's Disease and Synucleinopathies. PMID:30459551
CAARS: comparative assembly and annotation of RNA-Seq data. PMID:30452539
Characterization of the F-box Proteins FBXW2 and FBXL14 in the Initiation of Bone Regeneration in Transplants given to Nude Mice. PMID:30450135
Methylation-Based Classification of Cervical Squamous Cell Carcinoma into Two New Subclasses Differing in Immune-Related Gene Expression. PMID:30445744
The expression signature of cancer-associated KRAB-ZNF factors identified in TCGA pan-cancer transcriptomic data. PMID:30444046
Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes. PMID:30443895
Gene expression profile of muscle adaptation to high-intensity intermittent exercise training in young men. PMID:30429512
Identification of TEX101-associated Proteins Through Proteomic Measurement of Human Spermatozoa Homozygous for the Missense Variant rs35033974. PMID:30429210
funcExplorer: a tool for fast data-driven functional characterisation of high-throughput expression data. PMID:30428831
The Body-wide Transcriptome Landscape of Disease Models. PMID:30428375
Diabetes in Pregnancy and MicroRNAs: Promises and Limitations in Their Clinical Application. PMID:30424584
miRNA Mediated Noise Making of 3'UTR Mutations in Cancer. PMID:30424545
UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma. PMID:30420903
PTMiner: Localization and Quality Control of Protein Modifications Detected in an Open Search and Its Application to Comprehensive Post-translational Modification Characterization in Human Proteome. PMID:30420486
Bi-allelic POLR3A Loss-of-Function Variants Cause Autosomal-Recessive Wiedemann-Rautenstrauch Syndrome. PMID:30414627
Identifying a Novel Biomarker TOP2A of Clear Cell Renal Cell Carcinoma (ccRCC) Associated with Smoking by Co-Expression Network Analysis. PMID:30410595
Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs. PMID:30410047
Up-regulation of collagen proteins in colorectal liver metastasis compared with normal liver tissue. PMID:30409905
Identification of Core Biomarkers Associated with Outcome in Glioma: Evidence from Bioinformatics Analysis. PMID:30405856
A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer. PMID:30405805
Multivalent activation of GLP-1 and sulfonylurea receptors modulates β-cell second-messenger signaling and insulin secretion. PMID:30404557
Exploring Seipin: From Biochemistry to Bioinformatics Predictions. PMID:30402103
Regulation of Connexin32 by ephrin receptors and T-cell protein-tyrosine phosphatase. PMID:30401746
MitoMiner v4.0: an updated database of mitochondrial localization evidence, phenotypes and diseases. PMID:30398659
Perturbations of Neuron-Restrictive Silencing Factor Modulate Corticotropin-Releasing Hormone Gene Expression in the Human Cell Line BeWo. PMID:30397598
Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism. PMID:30397099
Host Peptidic Hormones Affecting Bacterial Biofilm Formation and Virulence. PMID:30396172
Comparative transcriptomics identifies genes differentially expressed in the intestine of a new fast-growing strain of common carp with higher unsaturated fatty acid content in muscle. PMID:30395585
Vitamin D stimulates multiple microRNAs to inhibit CRH and other pro-labor genes in human placenta. PMID:30395535
Integrated Epigenetic Mapping of Human and Mouse Salivary Gene Regulation. PMID:30392435
Laser capture microdissection-targeted mass spectrometry: a method for multiplexed protein quantification within individual layers of the cerebral cortex. PMID:30390066
X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family. PMID:30389958
Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects. PMID:30388400
HAVCR1 expression might be a novel prognostic factor for gastric cancer. PMID:30388143
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro. PMID:30387835
Proteomic profiling of liver tissue from the mdx-4cv mouse model of Duchenne muscular dystrophy. PMID:30386187
Detection of Shared Balancing Selection in the Absence of Trans-Species Polymorphism. PMID:30380122
From Single Level Analysis to Multi-Omics Integrative Approaches: A Powerful Strategy towards the Precision Oncology. PMID:30373182
Functional analysis of mammalian phospholipase D enzymes. PMID:30369483
CamurWeb: a classification software and a large knowledge base for gene expression data of cancer. PMID:30367574
Effect of equiaxial cyclic strain on cardiomyogenic induction in mesenchymal stem cells. PMID:30367393
Antiviral activity of the mineralocorticoid receptor NR3C2 against Herpes simplex virus Type 1 (HSV-1) infection. PMID:30367157
Targeted Analysis of Serum Proteins Encoded at Known Inflammatory Bowel Disease Risk Loci. PMID:30358838
BitterDB: taste ligands and receptors database in 2019. PMID:30357384
Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth. PMID:30356100
Druggability of Coronary Artery Disease Risk Loci. PMID:30354342
ACTA1 Novel Likely Pathogenic Variant in a Family With Dilated Cardiomyopathy. PMID:30354303
Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer. PMID:30349298
TissueEnrich: Tissue-specific gene enrichment analysis. PMID:30346488
Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions. PMID:30345971
Missense Mutations of the Pro65 Residue of PCGF2 Cause a Recognizable Syndrome Associated with Craniofacial, Neurological, Cardiovascular, and Skeletal Features. PMID:30343942
Aberrant PRDM9 expression impacts the pan-cancer genomic landscape. PMID:30341163
Evaluation of PACE4 isoforms as biomarkers in thyroid cancer. PMID:30340539
Novel MXD4-NUTM1 fusion transcript identified in primary ovarian undifferentiated small round cell sarcoma. PMID:30338611
IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line. PMID:30338032
Rapamycin in ischemic stroke: Old drug, new tricks? PMID:30334673
Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs. PMID:30333515
A Comparative Assessment of Human and Chimpanzee iPSC-derived Cardiomyocytes with Primary Heart Tissues. PMID:30333510
LncBook: a curated knowledgebase of human long non-coding RNAs. PMID:30329098
Interleukin 30 to Interleukin 40. PMID:30328794
Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients. PMID:30323977
ESS: A Tool for Genome-Scale Quantification of Essentiality Score for Reaction/Genes in Constraint-Based Modeling. PMID:30323767
Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma. PMID:30322894
Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs. PMID:30319685
The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease. PMID:30319631
Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts. PMID:30319613
Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins. PMID:30316580
Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN-FOS at composite DNA sites. PMID:30315111
Human Testis Extracellular Matrix Enhances Human Spermatogonial Stem Cell Survival In Vitro. PMID:30311859
Shortening of apparent transverse relaxation time of inorganic phosphate as a breast cancer biomarker. PMID:30311703
Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization. PMID:30309985
Comparison of breast cancer metastasis models reveals a possible mechanism of tumor aggressiveness. PMID:30305609
Human DREF/ZBED1 is a nuclear protein widely expressed in multiple cell types derived from all three primary germ layers. PMID:30304065
Histone Deacetylase Inhibition Has Targeted Clinical Benefit in ARID1A-Mutated Advanced Urothelial Carcinoma. PMID:30301863
Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations. PMID:30301787
Interface-Based Structural Prediction of Novel Host-Pathogen Interactions. PMID:30298406
Enhanced validation of antibodies for research applications. PMID:30297845
Haplosaurus computes protein haplotypes for use in precision drug design. PMID:30297836
Impact of chemotactic factors and receptors on the cancer immune infiltrate: a bioinformatics study revealing homogeneity and heterogeneity among patient cohorts. PMID:30288345
Prediction of gene regulatory enhancers across species reveals evolutionarily conserved sequence properties. PMID:30286077
Autoantibodies Against Perilipin 1 as a Cause of Acquired Generalized Lipodystrophy. PMID:30283460
Guidance Molecules in Vascular Smooth Muscle. PMID:30283356
Colonic epithelial miR-31 associates with the development of Crohn's phenotypes. PMID:30282822
A non-coding region near Follistatin controls head colour polymorphism in the Gouldian finch. PMID:30282656
A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein. PMID:30279450
psichomics: graphical application for alternative splicing quantification and analysis. PMID:30277515
Application of weighted gene co-expression network analysis to identify key modules and hub genes in oral squamous cell carcinoma tumorigenesis. PMID:30275705
Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease. PMID:30275566
Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline. PMID:30275468
Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma. PMID:30272346
Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research. PMID:30271982
Launching the C-HPP neXt-CP50 Pilot Project for Functional Characterization of Identified Proteins with No Known Function. PMID:30269496
Short Leucine-Rich Proteoglycans Modulate Complement Activity and Increase Killing of the Respiratory Pathogen Moraxella catarrhalis. PMID:30266767
Structure and Protein Interaction-Based Gene Ontology Annotations Reveal Likely Functions of Uncharacterized Proteins on Human Chromosome 17. PMID:30265558
A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder. PMID:30262571
Epigenetic Study in Parkinson's Disease: A Pilot Analysis of DNA Methylation in Candidate Genes in Brain. PMID:30261625
A short isoform of ATG7 fails to lipidate LC3/GABARAP. PMID:30258106
The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. PMID:30251625
A meta-analysis and bioinformatics exploration of the diagnostic value and molecular mechanism of miR-193a-5p in lung cancer. PMID:30250529
Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes. PMID:30250408
Optimisation of a serum albumin removal protocol for use in a proteomic study to identify the protein biomarkers for silent gastric ulceration in horses. PMID:30250392
A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach. PMID:30249792
Vimentin Diversity in Health and Disease. PMID:30248895
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome. PMID:30242179
Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer. PMID:30241606
Functional and phylogenetic characterization of noncanonical vitamin B12-binding proteins in zebrafish suggests involvement in cobalamin transport. PMID:30237171
Emerging Developments in Microbiome and Microglia Research: Implications for Neurodevelopmental Disorders. PMID:30233586
Absence of AIF1L contributes to cell migration and a poor prognosis of breast cancer. PMID:30233209
SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer. PMID:30231985
Large-scale investigation of the reasons why potentially important genes are ignored. PMID:30226837
Translational molecular imaging in exocrine pancreatic cancer. PMID:30225616
sox9b is required in cardiomyocytes for cardiac morphogenesis and function. PMID:30224706
Downregulation of FOXK2 is associated with poor prognosis in patients with gastric cancer. PMID:30221666
Frequency and signature of somatic variants in 1461 human brain exomes. PMID:30214067
Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation. PMID:30214039
ADAP1 limits neonatal cardiomyocyte hypertrophy by reducing integrin cell surface expression. PMID:30206251
A Computational Method for Classifying Different Human Tissues with Quantitatively Tissue-Specific Expressed Genes. PMID:30205473
Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD. PMID:30202070
Terminal exon characterization with TECtool reveals an abundance of cell-specific isoforms. PMID:30202060
Cell type-resolved human lung lipidome reveals cellular cooperation in lung function. PMID:30194354
Neuronal pentraxin receptor-1 is a new cerebrospinal fluid biomarker of Alzheimer's disease progression. PMID:30191060
xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction. PMID:30190786
Cross-tissue eQTL enrichment of associations in schizophrenia. PMID:30188921
The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer. PMID:30188895
Integrated measurement of intracellular proteins and transcripts in single cells. PMID:30178802
Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage. PMID:30175270
Study of mitotic chromatin supports a model of bookmarking by histone modifications and reveals nucleosome deposition patterns. PMID:30166406
Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney. PMID:30166318
Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer. PMID:30161001
Selenium-Encoded Isotopic Signature Targeted Profiling. PMID:30159393
Anti-ARHGAP26 Autoantibodies Are Associated With Isolated Cognitive Impairment. PMID:30158896
Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP. PMID:30158653
Region-Resolved Quantitative Proteome Profiling Reveals Molecular Dynamics Associated With Chronic Pain in the PNS and Spinal Cord. PMID:30154697
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes. PMID:30154505
MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology. PMID:30153342
Exploring the Role of Fallopian Ciliated Cells in the Pathogenesis of High-Grade Serous Ovarian Cancer. PMID:30149579
Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ. PMID:30135298
DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride. PMID:30132517
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. PMID:30125269
Chronic Adrenergic Signaling Causes Abnormal RNA Expression of Proliferative Genes in Fetal Sheep Islets. PMID:30124804
Prediagnostic circulating markers of inflammation and risk of oesophageal adenocarcinoma: a study within the National Cancer Institute Cohort Consortium. PMID:30121626
Na/K-ATPase Y260 Phosphorylation-mediated Src Regulation in Control of Aerobic Glycolysis and Tumor Growth. PMID:30120256
Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma. PMID:30119675
Identification of non-mutated neoantigens presented by TAP-deficient tumors. PMID:30115740
Systems level expression correlation of Ras GTPase regulators. PMID:30111366
Identification of pathways and genes associated with cerebral palsy. PMID:30109564
Approaches to target tractability assessment - a practical perspective. PMID:30108951
Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins. PMID:30108415
Proteomics: Clinical and research applications in respiratory diseases. PMID:30105802
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms. PMID:30101371
Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project. PMID:30099871
Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies. PMID:30097533
Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers. PMID:30090875
Proteomic distinction of renal oncocytomas and chromophobe renal cell carcinomas. PMID:30087584
CTCF maintains regulatory homeostasis of cancer pathways. PMID:30086769
FBXW7: a critical tumor suppressor of human cancers. PMID:30086763
Antibody validation: a view from the mountains. PMID:30086383
Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum. PMID:30086131
On the problem of confounders in modeling gene expression. PMID:30084962
A tissue-based draft map of the murine MHC class I immunopeptidome. PMID:30084848
Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours. PMID:30082739
Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor. PMID:30082484
A secretome profile indicative of oleate-induced proliferation of HepG2 hepatocellular carcinoma cells. PMID:30076294
ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport. PMID:30076131
Smoking-induced iron dysregulation in the lung. PMID:30075191
Bi-allelic Recessive Loss-of-Function Variants in FANCM Cause Non-obstructive Azoospermia. PMID:30075111
Familial Cancer Variant Prioritization Pipeline version 2 (FCVPPv2) applied to a papillary thyroid cancer family. PMID:30072699
Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma. PMID:30072578
Co-regulatory networks of human serum proteins link genetics to disease. PMID:30072576
Mechanistic Insights into CpG DNA and IL-15 Synergy in Promoting B Cell Chronic Lymphocytic Leukemia Clonal Expansion. PMID:30068596
Prognostic values of the inhibitor of DNA‑binding family members in breast cancer. PMID:30066902
Bacterial Outer Membrane Vesicles Induce Vitronectin Release Into the Bronchoalveolar Space Conferring Protection From Complement-Mediated Killing. PMID:30061873
Amelioration of Diabetic Nephropathy Using a Retinoic Acid Receptor β2 Agonist. PMID:30054312
BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery. PMID:30053270
Characterization of FGD5 Expression in Primary Breast Cancers and Lymph Node Metastases. PMID:30052477
Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts. PMID:30052023
Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways. PMID:30050127
Inhibitors of lysosomal function or serum starvation in control or LAMP2 deficient cells do not modify the cellular levels of Parkinson disease-associated DJ-1/PARK 7 protein. PMID:30048497
Identification of integrin drug targets for 17 solid tumor types. PMID:30046394
Liver-enriched Genes are Associated with the Prognosis of Patients with Hepatocellular Carcinoma. PMID:30046116
Epigenetic Variability Confounds Transcriptome but Not Proteome Profiling for Coexpression-based Gene Function Prediction. PMID:30042154
Age-Related Differential Structural and Transcriptomic Responses in the Hypertensive Heart. PMID:30038575
Appetite, Metabolism and Hormonal Regulation in Normal Ageing and Dementia. PMID:30036957
Transferrin receptor 1 in cancer: a new sight for cancer therapy. PMID:30034931
Targeting Pim Kinases and DAPK3 to Control Hypertension. PMID:30033129
VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival. PMID:30027561
Chemical and genetic control of IFNγ-induced MHCII expression. PMID:30021835
Alzheimer disease pathology and the cerebrospinal fluid proteome. PMID:30021611
A Universal Live Cell Barcoding-Platform for Multiplexed Human Single Cell Analysis. PMID:30018331
Downregulation of miR‑486‑5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing. PMID:30015845
Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk. PMID:30013180
A meta-analysis of transcriptome datasets characterizes malignant transformation from melanocytes and nevi to melanoma. PMID:30008882
Functional characteristics of novel pancreatic Pax6 regulatory elements. PMID:30007277
Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers. PMID:29997511
Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21. PMID:29997282
Lack of evidence for a causal role of CALR3 in monogenic cardiomyopathy. PMID:29988065
Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma. PMID:29987839
Silencing NIK potentiates anti-VEGF therapy in a novel 3D model of colorectal cancer angiogenesis. PMID:29983872
A Screening Rule for ℓ1-Regularized Ising Model Estimation. PMID:29983538
Loose ends: almost one in five human genes still have unresolved coding status. PMID:29982784
Epithelial origin of eosinophilic esophagitis. PMID:29980278
Creation of a myosin Va-TAP-tagged mouse and identification of potential myosin Va-interacting proteins in the cerebellum. PMID:29979496
ABRF Proteome Informatics Research Group (iPRG) 2016 Study: Inferring Proteoforms from Bottom-up Proteomics Data. PMID:29977167
Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer. PMID:29975776
MicroRNA interactome analysis predicts post-transcriptional regulation of ADRB2 and PPP3R1 in the hypercholesterolemic myocardium. PMID:29973623
Actionable Metabolic Pathways in Heart Failure and Cancer-Lessons From Cancer Cell Metabolism. PMID:29971237
Differential Integration of Transcriptome and Proteome Identifies Pan-Cancer Prognostic Biomarkers. PMID:29971090
Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15. PMID:29970016
Enteric Species F Human Adenoviruses use Laminin-Binding Integrins as Co-Receptors for Infection of Ht-29 Cells. PMID:29968781
Six novel susceptibility loci for coronary artery disease and cerebral infarction identified by longitudinal exome-wide association studies in a Japanese population. PMID:29963304
Genome sequencing as a first-line genetic test in familial dilated cardiomyopathy. PMID:29961767
xMD-miRNA-seq to generate near in vivo miRNA expression estimates in colon epithelial cells. PMID:29955168
Quantitative Proteomic Analysis Identifies AHNAK (Neuroblast Differentiation-associated Protein AHNAK) as a Novel Candidate Biomarker for Bladder Urothelial Carcinoma Diagnosis by Liquid-based Cytology. PMID:29950347
NF-kappaB Regulates Redox Status in Breast Cancer Subtypes. PMID:29949949
Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency. PMID:29949756
Quantification of Inflammasome Adaptor Protein ASC in Biological Samples by Multiple-Reaction Monitoring Mass Spectrometry. PMID:29948504
Presence of growth/differentiation factor-15 cytokine in human follicular fluid, granulosa cells, and oocytes. PMID:29948426
Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population. PMID:29945935
The arrhythmogenic cardiomyopathy-specific coding and non-coding transcriptome in human cardiac stromal cells. PMID:29940860
TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis. PMID:29940807
Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources. PMID:29931155
Regulation of Gastric Lgr5+ve Cell Homeostasis by Bone Morphogenetic Protein (BMP) Signaling and Inflammatory Stimuli. PMID:29930977
Molecular insights into cardiomyopathies associated with desmin (DES) mutations. PMID:29926427
Loss of the basic helix-loop-helix transcription factor Bhlhe41 induces cell death and impairs neurite outgrowth in Neuro2a cells. PMID:29926321
Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors. PMID:29925909
Circulating MicroRNAs: a Potential Biomarker for Cardiac Damage, Inflammatory Response, and Left Ventricular Function Recovery in Pediatric Viral Myocarditis. PMID:29916103
Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond-like syndrome. PMID:29914977
Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review. PMID:29910734
Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas. PMID:29909548
Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development. PMID:29907769
FOXA2 promotes the proliferation, migration and invasion, and epithelial mesenchymal transition in colon cancer. PMID:29896233
A homozygous FANCM frameshift pathogenic variant causes male infertility. PMID:29895858
Brain Cell Type Specific Gene Expression and Co-expression Network Architectures. PMID:29892006
TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer. PMID:29891505
A Computational Approach for Prioritizing Selection of Therapies Targeting Drug Resistant Variation in Anaplastic Lymphoma Kinase. PMID:29888064
A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits. PMID:29887380
Papillomavirus E2 protein is regulated by specific fibroblast growth factor receptors. PMID:29885490
Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies. PMID:29884306
Re-Evaluating E-Cadherin and β-Catenin: A Pan-Cancer Proteomic Approach with an Emphasis on Breast Cancer. PMID:29879416
The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses. PMID:29875205
Changing Trends in Computational Drug Repositioning. PMID:29874824
Precision histology: how deep learning is poised to revitalize histomorphology for personalized cancer care. PMID:29872706
The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment. PMID:29872573
GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. PMID:29872392
A candidate gene identification strategy utilizing mouse to human big-data mining: "3R-tenet" in COPD genetic research. PMID:29871630
Comparison of tumor related signaling pathways with known compounds to determine potential agents for lung adenocarcinoma. PMID:29870138
Meta-Analysis of Maternal and Fetal Transcriptomic Data Elucidates the Role of Adaptive and Innate Immunity in Preterm Birth. PMID:29867970
Deciphering the Pathological Role of Staphylococcal α-Toxin and Panton-Valentine Leukocidin Using a Novel Ex Vivo Human Skin Model. PMID:29867940
Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function. PMID:29867550
CharmeRT: Boosting Peptide Identifications by Chimeric Spectra Identification and Retention Time Prediction. PMID:29863353
Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites. PMID:29858488
Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs. PMID:29858229
TRAPPC11 and GOSR2 mutations associate with hypoglycosylation of α-dystroglycan and muscular dystrophy. PMID:29855340
Parenclitic networks for predicting ovarian cancer. PMID:29854310
Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1. PMID:29853471
Basement Membranes in Development and Disease. PMID:29853176
Severe neurocognitive and growth disorders due to variation in THOC2, an essential component of nuclear mRNA export machinery. PMID:29851191
CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer. PMID:29849821
A targeted in situ hybridization screen identifies putative seminal fluid proteins in a simultaneously hermaphroditic flatworm. PMID:29848299
miRNA-106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation. PMID:29845714
PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma. PMID:29844863
Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner. PMID:29844359
Increased GOLM1 Expression Independently Predicts Unfavorable Overall Survival and Recurrence-Free Survival in Lung Adenocarcinoma. PMID:29843532
Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. PMID:29808012
Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain. PMID:29806693
Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. PMID:29804876
Human microRNAs preferentially target genes with intermediate levels of expression and its formation by mammalian evolution. PMID:29795674
A Single-Cell Transcriptome Atlas of the Mouse Glomerulus. PMID:29794128
Casein kinase 1α: biological mechanisms and theranostic potential. PMID:29793495
A de novo KCNA1 Mutation in a Patient with Tetany and Hypomagnesemia. PMID:29791908
A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. PMID:29791858
rbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences. PMID:29789616
DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different. PMID:29788379
Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung. PMID:29788210
Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells. PMID:29786565
A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility. PMID:29786094
Systematic interrogation of diverse Omic data reveals interpretable, robust, and generalizable transcriptomic features of clinically successful therapeutic targets. PMID:29782487
C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases. PMID:29775578
The landscape of the non-canonical RNA-binding site of Gemin5 unveils a feedback loop counteracting the negative effect on translation. PMID:29771365
The importance of a halotyrosine dehalogenase for Drosophila fertility. PMID:29764939
Moving the Cellular Peptidome by Transporters. PMID:29761100
NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes. PMID:29759984
Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study. PMID:29755980
Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates. PMID:29752409
Assessing the functional association of intronic miRNAs with their host genes. PMID:29752351
Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity. PMID:29752062
Oncogenic role of miR‑183‑5p in lung adenocarcinoma: A comprehensive study of qPCR, in vitro experiments and bioinformatic analysis. PMID:29749535
NCS-1 is a regulator of calcium signaling in health and disease. PMID:29746899
Aberrant S100A16 expression might be an independent prognostic indicator of unfavorable survival in non-small cell lung adenocarcinoma. PMID:29746588
Automated transition analysis of activated gene regulation during diauxic nutrient shift in Escherichia coli and adipocyte differentiation in mouse cells. PMID:29745848
Inhibitory Effects of HIV-2 Vpx on Replication of HIV-1. PMID:29743354
NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland. PMID:29742982
CXCL12/CXCR4 Signaling Enhances Human PSC-Derived Hematopoietic Progenitor Function and Overcomes Early In Vivo Transplantation Failure. PMID:29742393
Transcellular transport of cobalamin in aortic endothelial cells. PMID:29741927
A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis. PMID:29736411
Highly multiplexed single-cell in situ RNA and DNA analysis with bioorthogonal cleavable fluorescent oligonucleotides. PMID:29732074
Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3. PMID:29730990
Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells. PMID:29729928
PregOMICS-Leveraging systems biology and bioinformatics for drug repurposing in maternal-child health. PMID:29726581
Improving the Efficiency of Vγ9Vδ2 T-Cell Immunotherapy in Cancer. PMID:29725332
Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer. PMID:29723302
Insulin acts as a repressive factor to inhibit the ability of PAR2 to induce islet cell transdifferentiation. PMID:29723131
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. PMID:29719619
Ancient Nuclear Receptor VDR With New Functions: Microbiome and Inflammation. PMID:29718408
Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis. PMID:29718219
Gestational Hypoxia and Developmental Plasticity. PMID:29717932
Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn. PMID:29717160
Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells. PMID:29712574
Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction. PMID:29702679
Impact of miR-140 Deficiency on Non-Alcoholic Fatty Liver Disease. PMID:29701903
The Emerging Immunogenetic Architecture of Schizophrenia. PMID:29701842
Interferon induced protein 35 exacerbates H5N1 influenza disease through the expression of IL-12p40 homodimer. PMID:29698474
Single-Cell in Situ RNA Analysis With Switchable Fluorescent Oligonucleotides. PMID:29696143
Profiling plasma extracellular vesicle by pluronic block-copolymer based enrichment method unveils features associated with breast cancer aggression, metastasis and invasion. PMID:29696079
Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions. PMID:29695497
Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington's Disease. PMID:29694882
Community-driven roadmap for integrated disease maps. PMID:29688273
Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies. PMID:29682908
Pregnancy-associated diamine oxidase originates from extravillous trophoblasts and is decreased in early-onset preeclampsia. PMID:29679053
3-Substituted 1,5-Diaryl-1 H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 1: Synthesis and Pharmacology. PMID:29678105
Cardiomyocytes have mosaic patterns of protein expression. PMID:29677652
Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall-King Hypothesis. PMID:29675414
Cystic fibrosis-related diabetes is caused by islet loss and inflammation. PMID:29669939
Glucose-regulated protein 78 is essential for cardiac myocyte survival. PMID:29666470
A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders. PMID:29665782
Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment. PMID:29663285
Computation and application of tissue-specific gene set weights. PMID:29659714
Mapping the tumour human leukocyte antigen (HLA) ligandome by mass spectrometry. PMID:29658117
Efficacy and Mechanism of Antitumor Activity of an Antibody Targeting Transferrin Receptor 1 in Mouse Models of Human Multiple Myeloma. PMID:29654211
A meta-analysis of public microarray data identifies biological regulatory networks in Parkinson's disease. PMID:29653596
Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes. PMID:29650774
Identification of Significant Gene Signatures and Prognostic Biomarkers for Patients With Cervical Cancer by Integrated Bioinformatic Methods. PMID:29642758
Wnt Signaling in Thyroid Homeostasis and Carcinogenesis. PMID:29642644
A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. PMID:29638227
The latent geometry of the human protein interaction network. PMID:29635317
Inhibition of DNA methyltransferase leads to increased genomic 5-hydroxymethylcytosine levels in hematopoietic cells. PMID:29632811
Alpha-v-containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP. PMID:29632205
Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation. PMID:29632189
The KASH-containing isoform of Nesprin1 giant associates with ciliary rootlets of ependymal cells. PMID:29630990
Plasma mSEPT9: A Novel Circulating Cell-free DNA-Based Epigenetic Biomarker to Diagnose Hepatocellular Carcinoma. PMID:29627389
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. PMID:29625592
A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development. PMID:29625070
The impact of tumor receptor heterogeneity on the response to anti-angiogenic cancer treatment. PMID:29623971
Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis. PMID:29623276
On the Role of Store-Operated Calcium Entry in Acute and Chronic Neurodegenerative Diseases. PMID:29623030
Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins. PMID:29620521
Peptide Sharing Between Viruses and DLX Proteins: A Potential Cross-Reactivity Pathway to Neuropsychiatric Disorders. PMID:29618965
A reference peptide database for proteome quantification based on experimental mass spectrum response curves. PMID:29617941
TISSUES 2.0: an integrative web resource on mammalian tissue expression. PMID:29617745
Mining the Human Tissue Proteome for Protein Citrullination. PMID:29610271
Homo sapiens-Specific Binding Site Variants within Brain Exclusive Enhancers Are Subject to Accelerated Divergence across Human Population. PMID:29608725
Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes. PMID:29599435
Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer. PMID:29596465
Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity. PMID:29589874
HLA and proteasome expression body map. PMID:29587858
Glycosyltransferase genes that cause monogenic congenital disorders of glycosylation are distinct from glycosyltransferase genes associated with complex diseases. PMID:29579191
Specification of trophoblast from embryonic stem cells exposed to BMP4. PMID:29579154
Wharton's Jelly Mesenchymal Stromal Cells Support the Expansion of Cord Blood-derived CD34+ Cells Mimicking a Hematopoietic Niche in a Direct Cell-cell Contact Culture System. PMID:29562783
A comprehensive catalog of predicted functional upstream open reading frames in humans. PMID:29562350
Gastric cancer biomarkers; A systems biology approach. PMID:29556568
The tubulin code in neuronal polarity. PMID:29554585
Cladribine treatment of multiple sclerosis is associated with depletion of memory B cells. PMID:29550884
Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes. PMID:29550255
Heterodimer Binding Scaffolds Recognition via the Analysis of Kinetically Hot Residues. PMID:29547506
Ensemble Methods with Voting Protocols Exhibit Superior Performance for Predicting Cancer Clinical Endpoints and Providing More Complete Coverage of Disease-Related Genes. PMID:29546047
Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity. PMID:29545808
Coordinated transcription of ANRIL and P16 genes is silenced by P16 DNA methylation. PMID:29545723
Identification of prefrontal cortex protein alterations in Alzheimer's disease. PMID:29541381
Transcriptome-derived stromal and immune scores infer clinical outcomes of patients with cancer. PMID:29541203
Global quantitative analysis of the human brain proteome in Alzheimer's and Parkinson's Disease. PMID:29533394
CoA synthase regulates mitotic fidelity via CBP-mediated acetylation. PMID:29531224
Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins. PMID:29530979
Is folic acid safe for non-muscle-invasive bladder cancer patients? An evidence-based cohort study. PMID:29529165
Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy. PMID:29529088
A proteomic landscape of diffuse-type gastric cancer. PMID:29520031
CMS-dependent prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer. PMID:29518181
The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis. PMID:29515971
Genome-wide transcriptome analysis identifies alternative splicing regulatory network and key splicing factors in mouse and human psoriasis. PMID:29515135
Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. PMID:29511213
Current applications of antibody microarrays. PMID:29507545
MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. PMID:29507340
Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. PMID:29507296
Rare variants in axonogenesis genes connect three families with sound-color synesthesia. PMID:29507195
Petri net-based prediction of therapeutic targets that recover abnormally phosphorylated proteins in muscle atrophy. PMID:29506508
A case of an infant suspected as IMAGE syndrome who were finally diagnosed with MIRAGE syndrome by targeted Mendelian exome sequencing. PMID:29506479
Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow. PMID:29500430
Carbonic Anhydrases: Role in pH Control and Cancer. PMID:29495652
Change of Title: Microarrays Becomes High-Throughput. PMID:29485608
Prognostic and predictive value of HURP in non‑small cell lung cancer. PMID:29484418
Ten hub genes associated with progression and prognosis of pancreatic carcinoma identified by co-expression analysis. PMID:29483831
The regulation of glycogenolysis in the brain. PMID:29483194
How Omics Data Can Be Used in Nephrology. PMID:29478865
Loss of Function of the Nuclear Receptor NR2F2, Encoding COUP-TF2, Causes Testis Development and Cardiac Defects in 46,XX Children. PMID:29478779
Recently Evolved Tumor Suppressor Transcript TP73-AS1 Functions as Sponge of Human-Specific miR-941. PMID:29474580
CGB5 expression is independently associated with poor overall survival and recurrence-free survival in patients with advanced gastric cancer. PMID:29473345
Unexplored therapeutic opportunities in the human genome. PMID:29472638
Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions. PMID:29472485
Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish. PMID:29468257
Adhesion GPCRs in Kidney Development and Disease. PMID:29468160
Identification, isolation and characterization of human LGR5-positive colon adenoma cells. PMID:29467240
Positive zip coding in small protein translocation. PMID:29462795
The altered expression of perineuronal net elements during neural differentiation. PMID:29456557
Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides. PMID:29453283
GPCRs in context: sexual dimorphism in the cardiovascular system. PMID:29451687
Access to the CNS: Biomarker Strategies for Dopaminergic Treatments. PMID:29450650
An in silico argument for mitochondrial microRNA as a determinant of primary non function in liver transplantation. PMID:29449571
Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density. PMID:29444691
How many human proteoforms are there? PMID:29443976
Transcriptome analysis reveals TMPRSS6 isoforms with distinct functionalities. PMID:29441715
Autophagy and Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Implications. PMID:29441009
Diurnal transcriptome atlas of a primate across major neural and peripheral tissues. PMID:29439024
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer. PMID:29436393
The PHD1 oxygen sensor in health and disease. PMID:29435987
Gadd45β silencing impaired viability and metastatic phenotypes in cholangiocarcinoma cells by modulating the EMT pathway. PMID:29435034
Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses. PMID:29432180
Tumor microenvironment heterogeneity: challenges and opportunities. PMID:29430386
GeneGini: Assessment via the Gini Coefficient of Reference "Housekeeping" Genes and Diverse Human Transporter Expression Profiles. PMID:29428416
Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations. PMID:29425227
Rce1: mechanism and inhibition. PMID:29424242
Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance. PMID:29423065
MELK expression correlates with tumor mitotic activity but is not required for cancer growth. PMID:29417930
HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells. PMID:29417297
Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction. PMID:29416706
LanCL1 protects prostate cancer cells from oxidative stress via suppression of JNK pathway. PMID:29416001
HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas. PMID:29409830
In Vitro Modeling of Leucine-Rich Repeat Kinase 2 G2019S-Mediated Parkinson's Disease Pathology. PMID:29402177
RNA-protein interaction detection in living cells. PMID:29400715
The tumour glyco-code as a novel immune checkpoint for immunotherapy. PMID:29398707
Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome. PMID:29395072
Cooperation between ETS variant 2 and Jumonji domain‑containing 2 histone demethylases. PMID:29393482
RNentropy: an entropy-based tool for the detection of significant variation of gene expression across multiple RNA-Seq experiments. PMID:29390085
The Ewing Sarcoma Secretome and Its Response to Activation of Wnt/beta-catenin Signaling. PMID:29386236
Expression profiles of Sox transcription factors within the postnatal rodent testes. PMID:29383560
Hypoxia-inducible factor-1α promotes cell survival during ammonia stress response in ovarian cancer stem-like cells. PMID:29383096
Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer. PMID:29382334
Single-Nucleotide Variations of the Human Nuclear Hormone Receptor Genes in 60,000 Individuals. PMID:29379896
Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo. PMID:29374152
Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. PMID:29374058
Proteomics Profiling of CLL Versus Healthy B-cells Identifies Putative Therapeutic Targets and a Subtype-independent Signature of Spliceosome Dysregulation. PMID:29367434
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. PMID:29364867
The diamond anniversary of tissue transglutaminase: a protein of many talents. PMID:29362136
Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and -9. PMID:29361803
A branching morphogenesis program governs embryonic growth of the thyroid gland. PMID:29361553
The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability. PMID:29361176
Contribution of Adipose Tissue to Development of Cancer. PMID:29357128
Regeneration in distantly related species: common strategies and pathways. PMID:29354283
LIMK/cofilin pathway and Slingshot are implicated in human colorectal cancer progression and chemoresistance. PMID:29352327
Membranous nephropathy associated with pregnancy: an anti-phospholipase A2 receptor antibody-positive case report. PMID:29349731
Identification of novel diagnostic biomarkers for thyroid carcinoma. PMID:29340074
Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms. PMID:29339080
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand. PMID:29337137
As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. PMID:29337136
Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells. PMID:29334988
Dynamic changes in copper homeostasis and post-transcriptional regulation of Atp7a during myogenic differentiation. PMID:29333545
Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR. PMID:29330362
Modelling the structure of a ceRNA-theoretical, bipartite microRNA-mRNA interaction network regulating intestinal epithelial cellular pathways using R programming. PMID:29329594
Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase. PMID:29326160
Defining tissue proteomes by systematic literature review. PMID:29323144
AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. PMID:29321668
Voltage-gated sodium channels: (NaV )igating the field to determine their contribution to visceral nociception. PMID:29318638
A genome-wide association study identifies only two ancestry specific variants associated with spontaneous preterm birth. PMID:29317701
The polarity protein Angiomotin p130 controls dendritic spine maturation. PMID:29317530
Identification of Transposable Elements Contributing to Tissue-Specific Expression of Long Non-Coding RNAs. PMID:29315213
Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome. PMID:29309034
Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents. PMID:29305616
POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain. PMID:29305536
Integration of multiple networks and pathways identifies cancer driver genes in pan-cancer analysis. PMID:29304754
Amphioxus SYCP1: a case of retrogene replacement and co-option of regulatory elements adjacent to the ParaHox cluster. PMID:29297095
Resistance to receptor-blocking therapies primes tumors as targets for HER3-homing nanobiologics. PMID:29288681
Comparative Proteomics Analysis of Urine Reveals Down-Regulation of Acute Phase Response Signaling and LXR/RXR Activation Pathways in Prostate Cancer. PMID:29286311
Using single-cell multiple omics approaches to resolve tumor heterogeneity. PMID:29285690
DE-kupl: exhaustive capture of biological variation in RNA-seq data through k-mer decomposition. PMID:29284518
Expitope 2.0: a tool to assess immunotherapeutic antigens for their potential cross-reactivity against naturally expressed proteins in human tissues. PMID:29282079
Cancer transcriptome profiling at the juncture of clinical translation. PMID:29279605
Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes. PMID:29275860
De novo large rare copy-number variations contribute to conotruncal heart disease in Chinese patients. PMID:29263819
Systems-epigenomics inference of transcription factor activity implicates aryl-hydrocarbon-receptor inactivation as a key event in lung cancer development. PMID:29262847
Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis. PMID:29262532
Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells. PMID:29259115
Evolutionary expansion of DNA hypomethylation in the mammalian germline genome. PMID:29259021
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. PMID:29257953
High expression of FLT3 is a risk factor in leukemia. PMID:29257272
Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α'. PMID:29236079
SLC9B1 methylation predicts fetal intolerance of labor. PMID:29235940
The landscape of miRNA editing in animals and its impact on miRNA biogenesis and targeting. PMID:29233923
Whole-Exome Sequencing Identifies a de novo AHDC1 Mutation in a Colombian Patient with Xia-Gibbs Syndrome. PMID:29230160
Identification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach. PMID:29229936
Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer. PMID:29229604
Comparative transcriptomic analysis of human placentae at term and preterm delivery. PMID:29228154
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain. PMID:29227469
Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines. PMID:29226804
Whole-exome sequencing for detecting inborn errors of immunity: overview and perspectives. PMID:29225788
Transcription and Remodeling Produce Asymmetrically Unwrapped Nucleosomal Intermediates. PMID:29225036
Genome-Wide Analysis of Barrett's Adenocarcinoma. A First Step Towards Identifying Patients at Risk and Developing Therapeutic Paths. PMID:29223109
Deciphering transcriptional regulation in human embryonic stem cells specified towards a trophoblast fate. PMID:29222466
Cellular FLIP long isoform (cFLIPL)-IKKα interactions inhibit IRF7 activation, representing a new cellular strategy to inhibit IFNα expression. PMID:29222334
Exploring digenic inheritance in arrhythmogenic cardiomyopathy. PMID:29221435
Immunohistochemical Localization of Fibrinogen C Domain Containing 1 on Epithelial and Mucosal Surfaces in Human Tissues. PMID:29220632
Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling. PMID:29212039
Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer. PMID:29210986
Co-expression network analysis identified FCER1G in association with progression and prognosis in human clear cell renal cell carcinoma. PMID:29209141
A novel correlation between ATP5A1 gene expression and progression of human clear cell renal cell carcinoma identified by co‑expression analysis. PMID:29207195
P4HB and PDIA3 are associated with tumor progression and therapeutic outcome of diffuse gliomas. PMID:29207176
The Human Cell Atlas. PMID:29206104
ATP2C2 and DYX1C1 are putative modulators of dyslexia-related MMR. PMID:29201552
New Strategies and Challenges in Lung Proteomics and Metabolomics. An Official American Thoracic Society Workshop Report. PMID:29192815
Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis. PMID:29190970
The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model. PMID:29190822
Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling. PMID:29187877
FAM13A as a Novel Hypoxia-Induced Gene in Non-Small Cell Lung Cancer. PMID:29187867
Associations between imprinted gene expression in the placenta, human fetal growth and preeclampsia. PMID:29187609
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control. PMID:29186125
A hypermorphic antioxidant response element is associated with increased MS4A6A expression and Alzheimer's disease. PMID:29179108
MitoCore: a curated constraint-based model for simulating human central metabolism. PMID:29178872
ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis. PMID:29178829
Spatiotemporal Proteomic Profiling of Huntington's Disease Inclusions Reveals Widespread Loss of Protein Function. PMID:29166617
FunCoup 4: new species, data, and visualization. PMID:29165593
An expression screen for aged-dependent microRNAs identifies miR-30a as a key regulator of aging features in human epidermis. PMID:29165315
IGFBP-4 expression is adversely associated with lung cancer prognosis. PMID:29163706
3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry. PMID:29162797
De novo variants in EBF3 are associated with hypotonia, developmental delay, intellectual disability, and autism. PMID:29162653
Interest of integrins targeting in glioblastoma according to tumor heterogeneity and cancer stem cell paradigm: an update. PMID:29156849
Zinc-finger proteins in health and disease. PMID:29152378
CD163 as a novel target gene of STAT3 is a potential therapeutic target for gastric cancer. PMID:29152078
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY. PMID:29149325
Immune signature profiling identified predictive and prognostic factors for esophageal squamous cell carcinoma. PMID:29147607
Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. PMID:29145845
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family. PMID:29142246
LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness. PMID:29137369
A Role of Sp1 Binding Motifs in Basal and Large T-Antigen-Induced Promoter Activities of Human Polyomavirus HPyV9 and Its Variant UF-1. PMID:29135936
Pathways of cellular proteostasis in aging and disease. PMID:29127110
Human Organ Tissue Identification by Targeted RNA Deep Sequencing to Aid the Investigation of Traumatic Injury. PMID:29125589
Integrative analysis of BSG expression in NPC through immunohistochemistry and public high-throughput gene expression data. PMID:29118919
EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis. PMID:29118343
ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance. PMID:29117122
Prognostic microRNAs and their potential molecular mechanism in pancreatic cancer: A study based on The Cancer Genome Atlas and bioinformatics investigation. PMID:29115476
Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View. PMID:29114206
Bioinformatics analysis of SRSF1-controlled gene networks in colorectal cancer. PMID:29113173
VarCards: an integrated genetic and clinical database for coding variants in the human genome. PMID:29112736
APOL1 Nephrotoxicity: What Does Ion Transport Have to Do With It? PMID:29110762
Comprehensive bioinformatics analysis of the characterization and determination underlying mechanisms of over-expression and co-expression of genes residing on 20q in colorectal cancer. PMID:29108255
Prediction of Host-Pathogen Interactions for Helicobacter pylori by Interface Mimicry and Implications to Gastric Cancer. PMID:29106933
Location matters: distinct DNA methylation patterns in GABAergic interneuronal populations from separate microcircuits within the human hippocampus. PMID:29106556
Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma. PMID:29103912
Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy. PMID:29100430
The RNA exosome and RNA exosome-linked disease. PMID:29093021
GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. PMID:29092903
An Investigation of the Single and Combined Phthalate Metabolite Effects on Human Chorionic Gonadotropin Expression in Placental Cells. PMID:29089286
Non-small cell lung cancer (NSCLC), EGFR downstream pathway activation and TKI targeted therapies sensitivity: Effect of the plasma membrane-associated NEU3. PMID:29088281
Commentary: HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing of CD44 during epithelial-mesenchymal transition. PMID:29085822
Helicobacter pylori Affects the Antigen Presentation Activity of Macrophages Modulating the Expression of the Immune Receptor CD300E through miR-4270. PMID:29085364
COMICS: Cartoon Visualization of Omics Data in Spatial Context Using Anatomical Ontologies. PMID:29083911
Ca2+ protein alpha 1D of CaV1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity. PMID:29079724
Framework and resource for more than 11,000 gene-transcript-protein-reaction associations in human metabolism. PMID:29078384
Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins. PMID:29075625
Trends in GPCR drug discovery: new agents, targets and indications. PMID:29075003
Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression. PMID:29069604
Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism. PMID:29069457
The DifferentialNet database of differential protein-protein interactions in human tissues. PMID:29069447
TCSBN: a database of tissue and cancer specific biological networks. PMID:29069445
Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor. PMID:29066620
The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance. PMID:29064388
The Challenge of Human Spermatozoa Proteome: A Systematic Review. PMID:29062791
A rapid and accurate approach for prediction of interactomes from co-elution data (PrInCE). PMID:29061110
Molecular-based diagnosis of multiple sclerosis and its progressive stage. PMID:29059494
Xenbase: a genomic, epigenomic and transcriptomic model organism database. PMID:29059324
Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease. PMID:29059182
miR-708-5p: a microRNA with emerging roles in cancer. PMID:29050362
CNS cell-type localization and LPS response of TLR signaling pathways. PMID:29043065
Ancestors' dietary patterns and environments could drive positive selection in genes involved in micronutrient metabolism-the case of cofactor transporters. PMID:29043008
The serum protein renalase reduces injury in experimental pancreatitis. PMID:29042438
The online Tabloid Proteome: an annotated database of protein associations. PMID:29040688
Advances in the Chromosome-Centric Human Proteome Project: looking to the future. PMID:29039980
Hepatic differentiation of human iPSCs in different 3D models: A comparative study. PMID:29039463
Cell-surface major vault protein promotes cancer progression through harboring mesenchymal and intermediate circulating tumor cells in hepatocellular carcinomas. PMID:29038587
TissGDB: tissue-specific gene database in cancer. PMID:29036590
Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β. PMID:29030430
CAR T Therapy Targeting ICAM-1 Eliminates Advanced Human Thyroid Tumors. PMID:29025766
In-depth proteomic analysis of tissue interstitial fluid for hepatocellular carcinoma serum biomarker discovery. PMID:29024941
ANO9/TMEM16J promotes tumourigenesis via EGFR and is a novel therapeutic target for pancreatic cancer. PMID:29024940
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data. PMID:29021715
Identification of Serological Biomarkers for Early Diagnosis of Lung Cancer Using a Protein Array-Based Approach. PMID:29021294
Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML. PMID:29017060
Temporal expression profiling of plasma proteins reveals oxidative stress in early stages of Type 1 Diabetes progression. PMID:28993202
Data Resources for Human Functional Genomics. PMID:28989986
Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development. PMID:28985528
Few Nuclear-Encoded Mitochondrial Gene Duplicates Contribute to Male Germline-Specific Functions in Humans. PMID:28985295
Chronic β2 -adrenoceptor agonist treatment alters muscle proteome and functional adaptations induced by high intensity training in young men. PMID:28983994
Role of adaptor protein p66Shc in renal pathologies. PMID:28978535
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. PMID:28977666
IMOTA: an interactive multi-omics tissue atlas for the analysis of human miRNA-target interactions. PMID:28977416
Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond-like features. PMID:28972538
The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. PMID:28965825
Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice. PMID:28961327
Folding Membrane Proteins by Deep Transfer Learning. PMID:28957654
Human hepatic gene expression signature of non-alcoholic fatty liver disease progression, a meta-analysis. PMID:28955037
Alterations in mRNA 3' UTR Isoform Abundance Accompany Gene Expression Changes in Human Huntington's Disease Brains. PMID:28954224
Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers. PMID:28953906
Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma. PMID:28945795
Protein structure and phenotypic analysis of pathogenic and population missense variants in STXBP1. PMID:28944233
The human protein atlas: A spatial map of the human proteome. PMID:28940711
The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays. PMID:28938075
In situ protein detection with enhanced specificity using DNA-conjugated antibodies and proximity ligation. PMID:28937142
hnRNP L controls HPV16 RNA polyadenylation and splicing in an Akt kinase-dependent manner. PMID:28934469
NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease. PMID:28934392
Involvement of the Integrin α1β1 in the Progression of Colorectal Cancer. PMID:28933766
Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling. PMID:28925397
Inflammatory cytokine production in tumor cells upon chemotherapy drug exposure or upon selection for drug resistance. PMID:28915246
A high resolution atlas of gene expression in the domestic sheep (Ovis aries). PMID:28915238
Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis. PMID:28912276
miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells. PMID:28905214
Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases. PMID:28902166
Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye. PMID:28901286
Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. PMID:28898695
RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. PMID:28894007
Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in Trypanosoma brucei. PMID:28887303
Analysis of the whole transcriptome from gingivo-buccal squamous cell carcinoma reveals deregulated immune landscape and suggests targets for immunotherapy. PMID:28886030
Slow fusion pore expansion creates a unique reaction chamber for co-packaged cargo. PMID:28882880
IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer. PMID:28882129
Identification of KANSARL as the first cancer predisposition fusion gene specific to the population of European ancestry origin. PMID:28881586
Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation. PMID:28878392
Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. PMID:28878041
IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury. PMID:28877988
Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers. PMID:28874546
Radiogenomics: Identification of Genomic Predictors for Radiation Toxicity. PMID:28865512
Krüppel-like factor 5 is essential for maintenance of barrier function in mouse colon. PMID:28864500
The Scaffolding Protein IQGAP1 Interacts with NLRC3 and Inhibits Type I IFN Production. PMID:28864474
The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma. PMID:28862757
Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. PMID:28861084
The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene. PMID:28859078
CTLA-4/CD80 pathway regulates T cell infiltration into pancreatic cancer. PMID:28856392
Inflammatory infiltrates in parathyroid tumors. PMID:28855268
Position Matters: Network Centrality Considerably Impacts Rates of Protein Evolution in the Human Protein-Protein Interaction Network. PMID:28854629
Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project. PMID:28853897
Extracellular Cytosolic Aspartate Aminotransferase Promotes Axonal Growth and Object Recognition Memory. PMID:28852933
Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome. PMID:28845240
ImmunoPET imaging of tissue factor expression in pancreatic cancer with 89Zr-Df-ALT-836. PMID:28843831
Sequence-structure relationships, expression profiles, and disease-associated mutations in the paralogs of phosphoglucomutase 1. PMID:28837627
Pervasive coexpression of spatially proximal genes is buffered at the protein level. PMID:28835372
Embryonic Stem Cell-Like Population in Dupuytren's Disease Expresses Components of the Renin-Angiotensin System. PMID:28831359
Nfib hemizygous mice are protected from hyperoxic lung injury and death. PMID:28830981
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations. PMID:28828399
MicroRNAs tend to synergistically control expression of genes encoding extensively-expressed proteins in humans. PMID:28828274
The role of the C-terminal D0 domain of flagellin in activation of Toll like receptor 5. PMID:28827825
Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis. PMID:28827734
Facile single-stranded DNA sequencing of human plasma DNA via thermostable group II intron reverse transcriptase template switching. PMID:28827600
Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision. PMID:28827588
Network analyses identify liver-specific targets for treating liver diseases. PMID:28827398
Systematic and Quantitative Assessment of Hydrogen Peroxide Reactivity With Cysteines Across Human Proteomes. PMID:28827280
Superoxide Dismutases in Pancreatic Cancer. PMID:28825637
Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma. PMID:28819306
Overexpression of Topoisomerase 2-Alpha Confers a Poor Prognosis in Pancreatic Adenocarcinoma Identified by Co-Expression Analysis. PMID:28815403
ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism. PMID:28811980
The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. PMID:28808947
High RBM3 expression is associated with an improved survival and oxaliplatin response in patients with metastatic colorectal cancer. PMID:28800641
Lumican delays melanoma growth in mice and drives tumor molecular assembly as well as response to matrix-targeted TAX2 therapeutic peptide. PMID:28794454
Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth. PMID:28794006
Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins. PMID:28793925
CODA: Integrating multi-level context-oriented directed associations for analysis of drug effects. PMID:28790372
Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity. PMID:28790177
Current State and Future Trends to Optimize the Care of African Americans with End-Stage Renal Disease. PMID:28787724
The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription. PMID:28787591
Uromodulin: from physiology to rare and complex kidney disorders. PMID:28781372
The Image Data Resource: A Bioimage Data Integration and Publication Platform. PMID:28775673
MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension. PMID:28771472
Kinase Activity of Fibroblast Growth Factor Receptor 3 Regulates Activity of the Papillomavirus E2 Protein. PMID:28768864
Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE. PMID:28768697
The Bos taurus-Bos indicus balance in fertility and milk related genes. PMID:28763475
Genome-Scale Modeling of NADPH-Driven β-Lapachone Sensitization in Head and Neck Squamous Cell Carcinoma. PMID:28762750
PLA2R binds to the annexin A2-S100A10 complex in human podocytes. PMID:28761153
SLC39A8 deficiency: biochemical correction and major clinical improvement by manganese therapy. PMID:28749473
Wilhelm et al. reply. PMID:28748931
Increased ERCC1 expression is linked to chromosomal aberrations and adverse tumor biology in prostate cancer. PMID:28747165
New Challenges to Study Heterogeneity in Cancer Redox Metabolism. PMID:28744456
The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation. PMID:28744217
Lactate oxidation facilitates growth of Mycobacterium tuberculosis in human macrophages. PMID:28744015
Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis. PMID:28742074
Erratum to: Treadmill Exercise Attenuates α-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson's Disease. PMID:28741160
HEMO, an ancestral endogenous retroviral envelope protein shed in the blood of pregnant women and expressed in pluripotent stem cells and tumors. PMID:28739914
Neisseria cinerea Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines. PMID:28739825
Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes. PMID:28736931
Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model. PMID:28736522
Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. PMID:28733458
Expression of the scaffold connector enhancer of kinase suppressor of Ras 1 (CNKSR1) is correlated with clinical outcome in pancreatic cancer. PMID:28732488
UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses. PMID:28732212
Gene expression signatures of human cell and tissue longevity. PMID:28721269
Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes. PMID:28717874
Bacterial infection imaging with [18F]fluoropropyl-trimethoprim. PMID:28716936
Differentiating mouse embryonic stem cells express markers of human endometrium. PMID:28716123
Predictive model of thrombospondin-1 and vascular endothelial growth factor in breast tumor tissue. PMID:28713587
A community proposal to integrate proteomics activities in ELIXIR. PMID:28713550
Arterial immune protein expression demonstrates the complexity of immune responses in Kawasaki disease arteritis. PMID:28707750
Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol. PMID:28701464
Genes Involved in Long-Term Memory Are Expressed in Testis of Cryptorchid Boys and Respond to GnRHa Treatment. PMID:28700985
Compound heterozygous SLC19A3 mutations further refine the critical promoter region for biotin-thiamine-responsive basal ganglia disease. PMID:28696212
Arete - candidate gene prioritization using biological network topology with additional evidence types. PMID:28694847
Putative role of an SLC45 H+/sugar cotransporter in mammalian spermatozoa. PMID:28689241
Spatiotemporal Proteomic Profiling of Human Cerebral Development. PMID:28687556
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies. PMID:28683746
Proteomic profiling of archaeological human bone. PMID:28680659
The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases. PMID:28680390
A Cell Fusion-Based Screening Method Identifies Glycosylphosphatidylinositol-Anchored Protein Ly6e as the Receptor for Mouse Endogenous Retroviral Envelope Syncytin-A. PMID:28679758
The Enterococcus faecalis virulence factor ElrA interacts with the human Four-and-a-Half LIM Domains Protein 2. PMID:28676674
Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide. PMID:28675388
Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells. PMID:28674184
Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway. PMID:28674149
PLA2R and THSD7A: Disparate Paths to the Same Disease? PMID:28674044
Institutional profile: the national Swedish academic drug discovery & development platform at SciLifeLab. PMID:28670468
Cervical Cancer Neoantigen Landscape and Immune Activity is Associated with Human Papillomavirus Master Regulators. PMID:28670312
Relevance of tissue specific subunit expression in channelopathies. PMID:28669898
Gene Expression Profiles for the Identification of Prevalent Atrial Fibrillation. PMID:28666990
KIBRA attains oncogenic activity by repressing RASSF1A. PMID:28664913
An atlas of bloodstream-accessible bone marrow proteins for site-directed therapy of acute myeloid leukemia. PMID:28663580
CARMIL family proteins as multidomain regulators of actin-based motility. PMID:28663287
METTL21B Is a Novel Human Lysine Methyltransferase of Translation Elongation Factor 1A: Discovery by CRISPR/Cas9 Knockout. PMID:28663172
The atopic march: current insights into skin barrier dysfunction and epithelial cell-derived cytokines. PMID:28658558
Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine. PMID:28655899
Affimer proteins are versatile and renewable affinity reagents. PMID:28654419
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway. PMID:28644436
Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice. PMID:28644012
Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology. PMID:28642799
A liver-specific gene expression panel predicts the differentiation status of in vitro hepatocyte models. PMID:28640507
The role of cullin4B in human cancers. PMID:28630798
Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities. PMID:28630053
Alternative Polyadenylation Patterns for Novel Gene Discovery and Classification in Cancer. PMID:28624626
Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells. PMID:28623304
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. PMID:28622513
Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines. PMID:28621943
The Therapeutic Potential of Anti-Inflammatory Exerkines in the Treatment of Atherosclerosis. PMID:28608819
Remodeling adipose tissue through in silico modulation of fat storage for the prevention of type 2 diabetes. PMID:28606124
Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS. PMID:28604659
The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development. PMID:28603670
Seasonal and flight-related variation of galectin expression in heart, liver and flight muscles of yellow-rumped warblers (Setophaga coronata). PMID:28597244
A comprehensive analysis and annotation of human normal urinary proteome. PMID:28596590
Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes. PMID:28596423
Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer. PMID:28596133
Computational prediction of lncRNA-mRNA interactionsby integrating tissue specificity in human transcriptome. PMID:28595592
Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism. PMID:28588231
NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes. PMID:28585553
Development of Novel Monoclonal Antibodies for Evaluation of Transmembrane Prostate Androgen-Induced Protein 1 (TMEPAI) Expression Patterns in Gastric Cancer. PMID:28584893
Alternative splicing shapes transcriptome but not proteome diversity in Physcomitrella patens. PMID:28578384
βIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons. PMID:28576936
Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease. PMID:28575649
Mutations in SULT2B1 Cause Autosomal-Recessive Congenital Ichthyosis in Humans. PMID:28575648
Genome-wide profiling of Sus scrofa circular RNAs across nine organs and three developmental stages. PMID:28575165
Biodistribution and Radiation Dosimetry of 18F-FTC-146 in Humans. PMID:28572487
Network analysis of the genomic basis of the placebo effect. PMID:28570268
Urinary exosomes reveal protein signatures in hypertensive patients with albuminuria. PMID:28562335
The Transcriptional Landscape of p53 Signalling Pathway. PMID:28558959
Canine Brachycephaly Is Associated with a Retrotransposon-Mediated Missplicing of SMOC2. PMID:28552356
A novel PRKAG2 mutation in a Chinese family with cardiac hypertrophy and ventricular pre-excitation. PMID:28546535
A random effects model for the identification of differential splicing (REIDS) using exon and HTA arrays. PMID:28545391
A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PMID:28542535
Analysis of primary-miRNA-3662 and its mature form may improve detection of the lung adenocarcinoma. PMID:28540403
Role of Intestinal LXRα in Regulating Post-prandial Lipid Excursion and Diet-Induced Hypercholesterolemia and Hepatic Lipid Accumulation. PMID:28536535
HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses. PMID:28533942
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. PMID:28530674
pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase. PMID:28530236
Role of carbonic anhydrases in skin wound healing. PMID:28524177
Architecture of the human interactome defines protein communities and disease networks. PMID:28514442
Pro-necrotic molecules impact local immunosurveillance in human breast cancer. PMID:28507808
Protein Markers Associated with an ALDH Sub-Population in Colorectal Cancer. PMID:28503055
MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome. PMID:28502612
Homogeneous pancreatic cancer spheroids mimic growth pattern of circulating tumor cell clusters and macrometastases: displaying heterogeneity and crater-like structure on inner layer. PMID:28497169
Revisiting olfactory receptors as putative drivers of cancer. PMID:28492065
Transcriptomics and the Mediterranean Diet: A Systematic Review. PMID:28486416
TSNAD: an integrated software for cancer somatic mutation and tumour-specific neoantigen detection. PMID:28484631
Claudin-4 Expression is Associated With Survival in Ovarian Cancer But Not With Chemotherapy Response. PMID:28481779
Expression and targeting of transcription factor ATF5 in dog gliomas. PMID:28480569
Multi-omics approaches to disease. PMID:28476144
Pancreatic Islet Protein Complexes and Their Dysregulation in Type 2 Diabetes. PMID:28473845
Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer. PMID:28469007
Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes. PMID:28465537
Immunohistochemical evaluation of epithelial ovarian carcinomas identifies three different expression patterns of the MX35 antigen, NaPi2b. PMID:28464843
The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF. PMID:28455445
PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer. PMID:28454353
Tissue Distribution of the MERS-Coronavirus Receptor in Bats. PMID:28446791
Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression. PMID:28445977
Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma. PMID:28445125
Factors influencing biased agonism in recombinant cells expressing the human α1A -adrenoceptor. PMID:28444738
A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. PMID:28444561
Social Behavior of Pet Dogs Is Associated with Peripheral OXTR Methylation. PMID:28443051
Elevated glypican-1 expression is associated with an unfavorable prognosis in pancreatic ductal adenocarcinoma. PMID:28440066
Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease. PMID:28438806
Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence. PMID:28433799
Angiotensin-converting enzyme 2 is a potential therapeutic target for EGFR-mutant lung adenocarcinoma. PMID:28433633
Gastric Proteins MUC5AC and TFF1 as Potential Diagnostic Markers of Colonic Sessile Serrated Adenomas/Polyps. PMID:28430953
Intrinsic protein disorder reduces small-scale gene duplicability. PMID:28430886
Evolutionary changes in lamin expression in the vertebrate lineage. PMID:28430006
Vaccination with inhibin-α provides effective immunotherapy against testicular stromal cell tumors. PMID:28428886
Expression of D-Amino Acid Oxidase (DAO/DAAO) and D-Amino Acid Oxidase Activator (DAOA/G72) during Development and Aging in the Human Post-mortem Brain. PMID:28428746
Precision physiology and rescue of brain ion channel disorders. PMID:28428202
MNS16A tandem repeat minisatellite of human telomerase gene: functional studies in colorectal, lung and prostate cancer. PMID:28427205
The effects of DLEU1 gene expression in Burkitt lymphoma (BL): potential mechanism of chemoimmunotherapy resistance in BL. PMID:28427156
When cancer needs what's non-essential. PMID:28422952
The clinical value, regulatory mechanisms, and gene network of the cancer-testis gene STK31 in pancreatic cancer. PMID:28422722
Global gene expression profiling of healthy human brain and its application in studying neurological disorders. PMID:28420888
Family with sequence similarity 13C (FAM13C) overexpression is an independent prognostic marker in prostate cancer. PMID:28415558
Comparative expression profiling of testis-enriched genes regulated during the development of spermatogonial cells. PMID:28414809
Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques. PMID:28414332
The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease. PMID:28410559
Tspan2: a tetraspanin protein involved in oligodendrogenesis and cancer metastasis. PMID:28408487
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. PMID:28407145
The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis. PMID:28405519
NUSAP1 promotes invasion and metastasis of prostate cancer. PMID:28404898
Shaping proteostasis at the cellular, tissue, and organismal level. PMID:28400444
Machine learning in computational biology to accelerate high-throughput protein expression. PMID:28398465
Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine. PMID:28396636
High-confidence coding and noncoding transcriptome maps. PMID:28396519
Proof-of-Concept Workflow for Establishing Reference Intervals of Human Urine Proteome for Monitoring Physiological and Pathological Changes. PMID:28396014
Emerging proteomics biomarkers and prostate cancer burden in Africa. PMID:28388542
Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility. PMID:28386063
The Proteins API: accessing key integrated protein and genome information. PMID:28383659
Novel RNA biomarkers of prostate cancer revealed by RNA-seq analysis of formalin-fixed samples obtained from Russian patients. PMID:28380430
Detect tissue heterogeneity in gene expression data with BioQC. PMID:28376718
Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci. PMID:28374850
VerSeDa: vertebrate secretome database. PMID:28365718
A Cell-Surface Membrane Protein Signature for Glioblastoma. PMID:28365151
The challenges with the validation of research antibodies. PMID:28357047
BCL6 promotes glioma and serves as a therapeutic target. PMID:28356518
ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. PMID:28351972
Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans. PMID:28346228
PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription. PMID:28345603
A quantitative method for screening and identifying molecular targets for nanomedicine. PMID:28341549
DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation. PMID:28340599
Genotype-based gene signature of glioma risk. PMID:28339748
Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice. PMID:28330952
MCPIP1, alias Regnase-1 binds and cleaves mRNA of C/EBPβ. PMID:28328949
Elevated fecal peptidase D at onset of colitis in Galphai2-/- mice, a mouse model of IBD. PMID:28323866
Visualization of tumor heterogeneity by in situ padlock probe technology in colorectal cancer. PMID:28321501
Inhibitors of GLUT/SLC2A Enhance the Action of BCNU and Temozolomide against High-Grade Gliomas. PMID:28319810
ExCAPE-DB: an integrated large scale dataset facilitating Big Data analysis in chemogenomics. PMID:28316655
The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals. PMID:28300784
Identification of a novel locus associated with skin colour in African-admixed populations. PMID:28300201
IRFinder: assessing the impact of intron retention on mammalian gene expression. PMID:28298237
Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer. PMID:28290516
Proteome-wide Mapping of Endogenous SUMOylation Sites in Mouse Testis. PMID:28289178
Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance. PMID:28287408
Ornithine Aminotransferase, an Important Glutamate-Metabolizing Enzyme at the Crossroads of Multiple Metabolic Pathways. PMID:28272331
Modulation of the Proteostasis Machinery to Overcome Stress Caused by Diminished Levels of t6A-Modified tRNAs in Drosophila. PMID:28272317
Social network architecture of human immune cells unveiled by quantitative proteomics. PMID:28263321
Integrating genomic data from high-throughput studies with computational modeling reveals differences in the molecular basis of hyposalivation between type 1 and type 2 diabetes. PMID:28255753
Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD. PMID:28254760
Let There Be Light! PMID:28248246
Genome-Scale Reconstruction of the Human Astrocyte Metabolic Network. PMID:28243200
DNA breaks and chromatin structural changes enhance the transcription of autoimmune regulator target genes. PMID:28242760
Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells. PMID:28241063
The Heterocellular Emergence of Colorectal Cancer. PMID:28239669
Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer. PMID:28235401
Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid. PMID:28223357
The versatility and paradox of GDF 11. PMID:28223232
Human Nup98 regulates the localization and activity of DExH/D-box helicase DHX9. PMID:28221134
Mutations in KIAA0753 cause Joubert syndrome associated with growth hormone deficiency. PMID:28220259
ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms? PMID:28220105
A Systematic Evaluation of Methods for Tailoring Genome-Scale Metabolic Models. PMID:28215528
Transcriptomic dynamics of breast cancer progression in the MMTV-PyMT mouse model. PMID:28212608
Identification of Extracellular Segments by Mass Spectrometry Improves Topology Prediction of Transmembrane Proteins. PMID:28211907
In situ generated D-peptidic nanofibrils as multifaceted apoptotic inducers to target cancer cells. PMID:28206986
A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFβ signaling and cause autosomal dominant spondylocarpotarsal synostosis. PMID:28205584
Paraneoplastic cerebellar degeneration associated with anti-ITPR1 antibodies. PMID:28203616
Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome. PMID:28196901
Untargeted metabolomics of colonic digests reveals kynurenine pathway metabolites, dityrosine and 3-dehydroxycarnitine as red versus white meat discriminating metabolites. PMID:28195169
Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells. PMID:28194645
Gene-based segregation method for identifying rare variants in family-based sequencing studies. PMID:28191685
The Drosophila Gene Expression Tool (DGET) for expression analyses. PMID:28187709
Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. PMID:28183841
Cloning, expression and molecular characterization of a Cystoisospora suis specific uncharacterized merozoite protein. PMID:28173829
The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients. PMID:28173181
The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men. PMID:28171660
Characterization of H type 1 and type 1 N-acetyllactosamine glycan epitopes on ovarian cancer specifically recognized by the anti-glycan monoclonal antibody mAb-A4. PMID:28167527
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. PMID:28166215
Insights into Diabetic Kidney Disease Using Urinary Proteomics and Bioinformatics. PMID:28159781
Evaluation of [18F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer. PMID:28157626
MISTIC-fusion proteins as antigens for high quality membrane protein antibodies. PMID:28148968
TBK1: a new player in ALS linking autophagy and neuroinflammation. PMID:28148298
Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast. PMID:28122942
GAD1 Gene Expression in Blood of Patients with First-Episode Psychosis. PMID:28122016
Accelerating the search for the missing proteins in the human proteome. PMID:28117396
Bicarbonate-sensing soluble adenylyl cyclase is present in the cell cytoplasm and nucleus of multiple shark tissues. PMID:28108644
Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress. PMID:28107650
A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network. PMID:28105929
Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention? PMID:28105425
Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis. PMID:28104354
GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord. PMID:28103900
Three-Dimensional Bioprinting Nanotechnologies towards Clinical Application of Stem Cells and Their Secretome in Salivary Gland Regeneration. PMID:28090208
FAM83 family oncogenes are broadly involved in human cancers: an integrative multi-omics approach. PMID:28078827
A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis. PMID:28069747
Analysis of Whole Exome Sequencing with Cardiometabolic Traits Using Family-Based Linkage and Association in the IRAS Family Study. PMID:28067407
Differential proteomic and oxidative profiles unveil dysfunctional protein import to adipocyte mitochondria in obesity-associated aging and diabetes. PMID:28064117
Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate. PMID:28059163
Network-Based Approach to Identify Potential Targets and Drugs that Promote Neuroprotection and Neurorepair in Acute Ischemic Stroke. PMID:28054643
A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma. PMID:28052770
PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion. PMID:28051998
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. PMID:28049840
Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View. PMID:28036022
A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival. PMID:28030848
Redox Control of Skeletal Muscle Regeneration. PMID:28027662
On-the-fly selection of cell-specific enhancers, genes, miRNAs and proteins across the human body using SlideBase. PMID:28025337
PD-L1 Is Not Constitutively Expressed on Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-γ and Can Be Expressed in the Tumor Microenvironment. PMID:28018348
Zebrafish Models for Dyslipidemia and Atherosclerosis Research. PMID:28018294
Secreted Proteins Defy the Expression Level-Evolutionary Rate Anticorrelation. PMID:28007979
Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection. PMID:28002492
The pan-cancer pathological regulatory landscape. PMID:28000771
Liver Enzymes and Risk of Ischemic Heart Disease and Type 2 Diabetes Mellitus: A Mendelian Randomization Study. PMID:27996050
Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility. PMID:27996046
Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma. PMID:27993630
Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer. PMID:27980417
Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model. PMID:27980102
Classical complement pathway activation in the nasal tissue of patients with chronic rhinosinusitis. PMID:27979430
Salivary and pellicle proteome: A datamining analysis. PMID:27966577
Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl. PMID:27966365
Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases. PMID:27965669
Gene-specific correlation of RNA and protein levels in human cells and tissues. PMID:27951527
Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer. PMID:27935821
Advances of the HUPO Human Proteome Project with broad applications for life sciences research. PMID:27935328
Expression of Cav1.3 calcium channel in the human and mouse colon: posttranscriptional inhibition by IFNγ. PMID:27932504
RNA sequencing of chorionic villi from recurrent pregnancy loss patients reveals impaired function of basic nuclear and cellular machinery. PMID:27929073
Tollip, an early regulator of the acute inflammatory response in the substantia nigra. PMID:27927222
Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome. PMID:27923875
A highly specific ratiometric two-photon fluorescent probe to detect dipeptidyl peptidase IV in plasma and living systems. PMID:27923191
Control of Gene Expression by RNA Binding Protein Action on Alternative Translation Initiation Sites. PMID:27923063
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. PMID:27920155
Maximising the potential of AKT inhibitors as anti-cancer treatments. PMID:27919797
Hepatocarcinogenesis in transgenic mice carrying hepatitis B virus pre-S/S gene with the sW172* mutation. PMID:27918551
Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation. PMID:27911818
Brain transcriptome atlases: a computational perspective. PMID:27909802
Quantitative and Selective Analysis of Feline Growth Related Proteins Using Parallel Reaction Monitoring High Resolution Mass Spectrometry. PMID:27907059
Sensitivity of GBM cells to cAMP agonist-mediated apoptosis correlates with CD44 expression and agonist resistance with MAPK signaling. PMID:27906173
The TissueNet v.2 database: A quantitative view of protein-protein interactions across human tissues. PMID:27899616
Receptor-Type Protein-Tyrosine Phosphatase ζ and Colony Stimulating Factor-1 Receptor in the Intestine: Cellular Expression and Cytokine- and Chemokine Responses by Interleukin-34 and Colony Stimulating Factor-1. PMID:27898738
The Human Skeletal Muscle Proteome Project: a reappraisal of the current literature. PMID:27897395
IDENTIFYING CANCER SPECIFIC METABOLIC SIGNATURES USING CONSTRAINT-BASED MODELS. PMID:27897000
A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction. PMID:27896283
UGT1A1*6, UGT1A7*3 and UGT1A9*1b polymorphisms are predictive markers for severe toxicity in patients with metastatic gastrointestinal cancer treated with irinotecan-based regimens. PMID:27895797
Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. PMID:27894104
Physiologically-based modeling to predict the clinical behavior of monoclonal antibodies directed against lymphocyte antigens. PMID:27892793
The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4. PMID:27888281
Patterns of ribosomal protein expression specify normal and malignant human cells. PMID:27884178
Personalized Proteomics: The Future of Precision Medicine. PMID:27882306
Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL. PMID:27875259
Quantitative secretomic analysis of pancreatic cancer cells in serum-containing conditioned medium. PMID:27869176
Evaluation of the genetic basis of primary hypoadrenocorticism in Standard Poodles using SNP array genotyping and whole-genome sequencing. PMID:27864587
ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer. PMID:27863473
Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation. PMID:27861515
SNAP23 promotes the malignant process of ovarian cancer. PMID:27855700
Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. PMID:27854507
RNA-seq based transcriptomic map reveals new insights into mouse salivary gland development and maturation. PMID:27852218
[Autoantibody-associated autoimmune encephalitis and cerebellitis : Clinical presentation, diagnostic work-up and treatment]. PMID:27847964
Haploinsufficiency of KMT2B, Encoding the Lysine-Specific Histone Methyltransferase 2B, Results in Early-Onset Generalized Dystonia. PMID:27839873
Adhesion GPCRs in Tumorigenesis. PMID:27832497
Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues. PMID:27824084
Microarray expression profiling identifies genes, including cytokines, and biofunctions, as diapedesis, associated with a brain metastasis from a papillary thyroid carcinoma. PMID:27822408
Illuminating a plant's tissue-specific metabolic diversity using computational metabolomics and information theory. PMID:27821729
Modeling Gene Regulation in Liver Hepatocellular Carcinoma with Random Forests. PMID:27818995
From Proteomic Analysis to Potential Therapeutic Targets: Functional Profile of Two Lung Cancer Cell Lines, A549 and SW900, Widely Studied in Pre-Clinical Research. PMID:27814385
Characterization of a male reproductive transcriptome for Peromyscus eremicus (Cactus mouse). PMID:27812417
Progress in the Chromosome-Centric Human Proteome Project as Highlighted in the Annual Special Issue IV. PMID:27809547
Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx. PMID:27805811
Downregulation of EGFR in hypoxic, diffusion-limited areas of squamous cell carcinomas of the head and neck. PMID:27802455
Path2enet: generation of human pathway-derived networks in an expression specific context. PMID:27801297
Evolutionary hallmarks of the human proteome: chasing the age and coregulation of protein-coding genes. PMID:27801289
RNA-Seq Transcriptomic Responses of Full-Thickness Dermal Excision Wounds to Pseudomonas aeruginosa Acute and Biofilm Infection. PMID:27792773
Upstream Open Reading Frames Located in the Leader of Protein Kinase Mζ mRNA Regulate Its Translation. PMID:27790092
Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy. PMID:27788492
Infantile Hemangioma Originates From A Dysregulated But Not Fully Transformed Multipotent Stem Cell. PMID:27786256
Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy. PMID:27776522
The state of play in higher eukaryote gene annotation. PMID:27773922
Inducible expression of cancer-testis antigens in human prostate cancer. PMID:27769045
Identification of internalin-A-like virulent proteins in Leishmania donovani. PMID:27765050
Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma. PMID:27764136
Equilibrative nucleoside transporters-A review. PMID:27759477
N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models. PMID:27757071
An Ancient Fecundability-Associated Polymorphism Switches a Repressor into an Enhancer of Endometrial TAP2 Expression. PMID:27745831
Molecular classification of Crohn's disease reveals two clinically relevant subtypes. PMID:27742763
The circadian coordination of cell biology. PMID:27738003
Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research. PMID:27713570
Alternative Splicing May Not Be the Key to Proteome Complexity. PMID:27712956
Network analysis of mitonuclear GWAS reveals functional networks and tissue expression profiles of disease-associated genes. PMID:27704213
Profiling cancer testis antigens in non-small-cell lung cancer. PMID:27699219
Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling. PMID:27697518
Targeted next-generation sequencing for TP53, RAS, BRAF, ALK and NF1 mutations in anaplastic thyroid cancer. PMID:27696251
Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions. PMID:27694853
Decreased Expression of SRSF2 Splicing Factor Inhibits Apoptotic Pathways in Renal Cancer. PMID:27690003
Integration of zebrafish fin regeneration genes with expression data of human tumors in silico uncovers potential novel melanoma markers. PMID:27689402
Detection of candidate biomarkers of prostate cancer progression in serum: a depletion-free 3D LC/MS quantitative proteomics pilot study. PMID:27685442
The NIH Protein Capture Reagents Program (PCRP): a standardized protein affinity reagent toolbox. PMID:27684578
Deconvolution of the Human Endothelial Transcriptome. PMID:27684186
Proteomic Analysis of Non-depleted Serum Proteins from Bottlenose Dolphins Uncovers a High Vanin-1 Phenotype. PMID:27667588
Multi-omics Quantification of Species Variation of Escherichia coli Links Molecular Features with Strain Phenotypes. PMID:27667363
A bead-based western for high-throughput cellular signal transduction analyses. PMID:27659302
Isolation and expression of the human gametocyte-specific factor 1 gene (GTSF1) in fetal ovary, oocytes, and preimplantation embryos. PMID:27646122
A novel mouse model for the identification of thioredoxin-1 protein interactions. PMID:27639450
Fluid biomarkers for mild traumatic brain injury and related conditions. PMID:27632903
Validation of specificity of antibodies for immunohistochemistry: the case of ROR2. PMID:27631337
Constructing Bayesian networks by integrating gene expression and copy number data identifies NLGN4Y as a novel regulator of prostate cancer progression. PMID:27626693
PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status. PMID:27626492
Proteomic profiling of human islets collected from frozen pancreata using laser capture microdissection. PMID:27620696
The ever-expanding myokinome: discovery challenges and therapeutic implications. PMID:27616294
Angelman syndrome - insights into a rare neurogenetic disorder. PMID:27615419
Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients. PMID:27612591
Comparative analysis of housekeeping and tissue-specific driver nodes in human protein interaction networks. PMID:27612563
Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor. PMID:27610270
What Signatures Dominantly Associate with Gene Age? PMID:27609935
CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease. PMID:27604409
Putative functions of tissue kallikrein-related peptidases in vaginal fluid. PMID:27603220
Data sources for in vivo molecular profiling of human phenotypes. PMID:27599755
Gene expression of immediate early genes of AP-1 transcription factor in human peripheral blood mononuclear cells in response to ionizing radiation. PMID:27586508
ANGIOGENES: knowledge database for protein-coding and noncoding RNA genes in endothelial cells. PMID:27582018
Detection of Missing Proteins Using the PRIDE Database as a Source of Mass Spectrometry Evidence. PMID:27581094
Pigment epithelium-derived factor (PEDF) normalizes matrix defects in iPSCs derived from Osteogenesis imperfecta Type VI. PMID:27579219
The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation. PMID:27578796
Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules. PMID:27578149
Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder. PMID:27577603
Highlights of the Biology and Disease-driven Human Proteome Project, 2015-2016. PMID:27573249
MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma. PMID:27572323
Mapping the Cell-Surface N-Glycoproteome of Human Hepatocytes Reveals Markers for Selecting a Homogeneous Population of iPSC-Derived Hepatocytes. PMID:27569060
Analysis of ARMC5 expression in human tissues. PMID:27568465
Identification of a novel progenitor cell marker, grainyhead-like 2 in the developing pituitary. PMID:27564454
A Cell-type-resolved Liver Proteome. PMID:27562671
The multi-omic landscape of transcription factor inactivation in cancer. PMID:27562343
Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1. PMID:27556547
Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma. PMID:27545456
Mapping paths: new approaches to dissect eukaryotic signaling circuitry. PMID:27540473
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease. PMID:27532054
Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. PMID:27515689
Pangolin genomes and the evolution of mammalian scales and immunity. PMID:27510566
The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation. PMID:27507887
Genetic mapping of canine fear and aggression. PMID:27503363
A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis. PMID:27503255
The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. PMID:27501152
A Genome-Scale Investigation of How Sequence, Function, and Tree-Based Gene Properties Influence Phylogenetic Inference. PMID:27492233
Prediction of scaffold proteins based on protein interaction and domain architectures. PMID:27490120
Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM). PMID:27489532
Metrics for the Human Proteome Project 2016: Progress on Identifying and Characterizing the Human Proteome, Including Post-Translational Modifications. PMID:27487407
Multiplex matrix network analysis of protein complexes in the human TCR signalosome. PMID:27485017
Association of TGFβ signaling with the maintenance of a quiescent stem cell niche in human oral mucosa. PMID:27480259
Representing and querying disease networks using graph databases. PMID:27462371
Withdrawn: Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. PMID:27454361
Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders. PMID:27453931
Cross-reactivity between annexin A2 and Beta-2-glycoprotein I in animal models of antiphospholipid syndrome. PMID:27449504
Meta-analysis of gene expression profiles identifies differential biomarkers for hepatocellular carcinoma and cholangiocarcinoma. PMID:27448818
The mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy. PMID:27447563
Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition. PMID:27436874
Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use. PMID:27436286
Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study. PMID:27421136
Crowdsourcing biomedical research: leveraging communities as innovation engines. PMID:27418159
Branched multipeptide immunotherapy for glioblastoma using human leukocyte antigen-A*0201-restricted cytotoxic T-lymphocyte epitopes from ERBB2, BIRC5 and CD99. PMID:27409668
Loss of MYC and E-box3 binding contributes to defective MYC-mediated transcriptional suppression of human MC-let-7a-1~let-7d in glioblastoma. PMID:27409345
Delineation of autoantibody repertoire through differential proteogenomics in hepatitis C virus-induced cryoglobulinemia. PMID:27403724
Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks. PMID:27403431
Identification of lung-specific genes by meta-analysis of multiple tissue RNA-seq data. PMID:27398317
Decorin-mediated inhibition of the migration of U87MG glioma cells involves activation of autophagy and suppression of TGF-β signaling. PMID:27398310
Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules. PMID:27385551
Nuclear import sequence identification in hOAS3 protein. PMID:27379722
HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective. PMID:27379525
H11/HSPB8 Restricts HIV-2 Vpx to Restore the Anti-Viral Activity of SAMHD1. PMID:27379031
Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies. PMID:27377311
Computational genomics tools for dissecting tumour-immune cell interactions. PMID:27376489
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. PMID:27374120
Recon 2.2: from reconstruction to model of human metabolism. PMID:27358602
Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels. PMID:27357396
Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells. PMID:27355192
miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy. PMID:27350436
Matricellular TSP-1 as a target of interest for impeding melanoma spreading: towards a therapeutic use for TAX2 peptide. PMID:27349907
P2A-Fluorophore Tagging of BRAF Tightly Links Expression to Fluorescence In Vivo. PMID:27348307
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance. PMID:27345421
Transcriptomic analyses of genes and tissues in inherited sensory neuropathies. PMID:27343803
ImmunoPET for assessing the differential uptake of a CD146-specific monoclonal antibody in lung cancer. PMID:27342417
Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis. PMID:27339464
Beta-3 adrenergic agonists reduce pulmonary vascular resistance and improve right ventricular performance in a porcine model of chronic pulmonary hypertension. PMID:27328822
SRF promotes gastric cancer metastasis through stromal fibroblasts in an SDF1-CXCR4-dependent manner. PMID:27323859
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein. PMID:27323809
Targeted Vaccination against Human α-Lactalbumin for Immunotherapy and Primary Immunoprevention of Triple Negative Breast Cancer. PMID:27322324
Association, characterisation and meta-analysis of SNPs linked to general reading ability in a German dyslexia case-control cohort. PMID:27312598
New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology. PMID:27308565
Advanced Multidimensional Separations in Mass Spectrometry: Navigating the Big Data Deluge. PMID:27306312
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR. PMID:27298316
FOXN3 Regulates Hepatic Glucose Utilization. PMID:27292639
Emergence and Evolution of Hominidae-Specific Coding and Noncoding Genomic Sequences. PMID:27289096
Global, quantitative and dynamic mapping of protein subcellular localization. PMID:27278775
Omics databases on kidney disease: where they can be found and how to benefit from them. PMID:27274817
Association-heterogeneity mapping identifies an Asian-specific association of the GTF2I locus with rheumatoid arthritis. PMID:27272985
Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis. PMID:27264872
ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism. PMID:27260404
Transcriptomic Segregation of Human Autoantigens Useful for the Diagnosis of Autoimmune Diseases. PMID:27259330
A Common Variant at the 14q32 Endometrial Cancer Risk Locus Activates AKT1 through YY1 Binding. PMID:27259051
P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis. PMID:27254077
EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMT. PMID:27253373
Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow. PMID:27250503
The hydrogen sulfide metabolite trimethylsulfonium is found in human urine. PMID:27247020
Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor. PMID:27243554
An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. PMID:27239938
Pigment Epithelium-Derived Factor (PEDF) is a Determinant of Stem Cell Fate: Lessons from an Ultra-Rare Disease. PMID:27239449
Current state of the art for enhancing urine biomarker discovery. PMID:27232439
Data integration to prioritize drugs using genomics and curated data. PMID:27231484
Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria. PMID:27230523
Connexin and pannexin channels in cancer. PMID:27229305
Comparative Proteomic Analysis of Whole-Gut Lavage Fluid and Pancreatic Juice Reveals a Less Invasive Method of Sampling Pancreatic Secretions. PMID:27228405
Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication. PMID:27225481
Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury. PMID:27224670
Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis. PMID:27216817
A novel COL4A1 frameshift mutation in familial kidney disease: the importance of the C-terminal NC1 domain of type IV collagen. PMID:27190376
Emerging role for regulated in development and DNA damage 1 (REDD1) in the regulation of skeletal muscle metabolism. PMID:27189933
Identification of brain-enriched proteins in the cerebrospinal fluid proteome by LC-MS/MS profiling and mining of the Human Protein Atlas. PMID:27186164
Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy. PMID:27185954
Systems-level analysis of human aging genes shed new light on mechanisms of aging. PMID:27179790
Brucella melitensis and Mycobacterium tuberculosis depict overlapping gene expression patterns induced in infected THP-1 macrophages. PMID:27175205
PepPSy: a web server to prioritize gene products in experimental and biocuration workflows. PMID:27173522
Erythropoietin Pathway: A Potential Target for the Treatment of Depression. PMID:27164096
Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response. PMID:27161320
EGFR Activation Leads to Cell Death Independent of PI3K/AKT/mTOR in an AD293 Cell Line. PMID:27153109
Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses. PMID:27152965
Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes. PMID:27152864
The Response of microRNAs to Solar UVR in Skin-Resident Melanocytes Differs between Melanoma Patients and Healthy Persons. PMID:27149382
De novo truncating variants in the AHDC1 gene encoding the AT-hook DNA-binding motif-containing protein 1 are associated with intellectual disability and developmental delay. PMID:27148574
Tetraspanin CD151 Promotes Initial Events in Human Cytomegalovirus Infection. PMID:27147745
NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes. PMID:27144453
Cross-tissue Analysis of Gene and Protein Expression in Normal and Cancer Tissues. PMID:27142790
Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation. PMID:27142428
Five endometrial cancer risk loci identified through genome-wide association analysis. PMID:27135401
Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation. PMID:27127173
Pigment epithelium-derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade. PMID:27127101
BMP2/BMPR1A is linked to tumour progression in dedifferentiated liposarcomas. PMID:27114889
Urate Handling in the Human Body. PMID:27105641
Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners. PMID:27100087
g:Profiler-a web server for functional interpretation of gene lists (2016 update). PMID:27098042
SRC kinase inhibition with saracatinib limits the development of osteolytic bone disease in multiple myeloma. PMID:27095574
Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies. PMID:27094239
HDAC6-mediated EGFR stabilization and activation restrict cell response to sorafenib in non-small cell lung cancer cells. PMID:27090797
Dynamics of Protein Expression Reveals Primary Targets and Secondary Messengers of Estrogen Receptor Alpha Signaling in MCF-7 Breast Cancer Cells. PMID:27067054
Regulating the Rate of Molecular Self-Assembly for Targeting Cancer Cells. PMID:27062481
Clustered mutations in hominid genome evolution are consistent with APOBEC3G enzymatic activity. PMID:27056836
Mouse Sox17 haploinsufficiency leads to female subfertility due to impaired implantation. PMID:27053385
A physiome interoperability roadmap for personalized drug development. PMID:27051513
Specific c-Jun target genes in malignant melanoma. PMID:27050748
Identification of Differentially Expressed Genes through Integrated Study of Alzheimer's Disease Affected Brain Regions. PMID:27050411
PDZ binding kinase (PBK) is a theranostic target for nasopharyngeal carcinoma: driving tumor growth via ROS signaling and correlating with patient survival. PMID:27049917
Genic insights from integrated human proteomics in GeneCards. PMID:27048349
Transcriptomics resources of human tissues and organs. PMID:27044256
Screening of Two ADH4 Variations in a Swedish Cluster Headache Case-Control Material. PMID:27041676
[Caspase-1 regulates autoinflammation in rheumatic diseases]. PMID:27034076
The biology of DHX9 and its potential as a therapeutic target. PMID:27034008
Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome. PMID:27030248
A Systematic Characterization of Aquaporin-9 Expression in Human Normal and Pathological Tissues. PMID:27026296
RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells. PMID:27015414
Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis. PMID:27013584
Utilization of HPASubC for the Identification of Sinusoid-Specific Proteins in the Liver. PMID:27005832
Small ubiquitin-related modifier 1 is involved in hepatocellular carcinoma progression via mediating p65 nuclear translocation. PMID:26993772
Integrin signalling regulates YAP and TAZ to control skin homeostasis. PMID:26989177
Radioimmunotherapy of prostate cancer targeting human kallikrein-related peptidase 2. PMID:26983637
In silico and experimental analyses predict the therapeutic value of an EZH2 inhibitor GSK343 against hepatocellular carcinoma through the induction of metallothionein genes. PMID:26973856
Rare renal ciliopathies in non-consanguineous families that were identified by targeted resequencing. PMID:26968886
Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition. PMID:26967563
Enzyme-Instructed Self-Assembly of Small D-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells. PMID:26966844
Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma. PMID:26956916
Apolipoprotein L1 and Kidney Disease in African Americans. PMID:26947522
Preeclampsia and Inflammatory Preterm Labor Alter the Human Placental Hematopoietic Niche. PMID:26944948
Reconstruction of Tissue-Specific Metabolic Networks Using CORDA. PMID:26942765
The Predictive Link between Matrix and Metastasis. PMID:26942108
Type 1 diabetes cadaveric human pancreata exhibit a unique exocrine tissue proteomic profile. PMID:26935967
Galectin signatures contribute to the heterogeneity of breast cancer and provide new prognostic information and therapeutic targets. PMID:26933916
The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases. PMID:26924986
Label-free proteomic methodology for the analysis of human kidney stone matrix composition. PMID:26924944
An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer. PMID:26921330
The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis. PMID:26920220
Differential mouse-strain specific expression of Junctional Adhesion Molecule (JAM)-B in placental structures. PMID:26914234
Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease. PMID:26911677
Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases. PMID:26893370
Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer. PMID:26882907
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value. PMID:26877874
Single-cell Transcriptome Study as Big Data. PMID:26876720
Mass spectrometric quantification of salivary metanephrines-A study in healthy subjects. PMID:26874200
Circular RNA profile in gliomas revealed by identification tool UROBORUS. PMID:26873924
Drugging Membrane Protein Interactions. PMID:26863923
Simvastatin Sodium Salt and Fluvastatin Interact with Human Gap Junction Gamma-3 Protein. PMID:26863535
Novel SLC19A3 Promoter Deletion and Allelic Silencing in Biotin-Thiamine-Responsive Basal Ganglia Encephalopathy. PMID:26863430
Anoctamin 2 identified as an autoimmune target in multiple sclerosis. PMID:26862169
Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools. PMID:26858650
Family-wide Structural Analysis of Human Numb-Associated Protein Kinases. PMID:26853940
Benchmarking Procedures for High-Throughput Context Specific Reconstruction Algorithms. PMID:26834640
Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway. PMID:26831087
Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1. PMID:26830021
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. PMID:26829750
PDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δ. PMID:26819372
Unraveling Molecular Differences of Gastric Cancer by Label-Free Quantitative Proteomics Analysis. PMID:26805816
Hyperpolarization-activated cation and T-type calcium ion channel expression in porcine and human renal pacemaker tissues. PMID:26805464
Global analysis of human duplicated genes reveals the relative importance of whole-genome duplicates originated in the early vertebrate evolution. PMID:26801093
The biochemical and mass spectrometric profiling of the dystrophin complexome from skeletal muscle. PMID:26793286
Small Molecule Inhibitors of Protein Arginine Methyltransferases. PMID:26789238
Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes. PMID:26783963
Structural basis and function of XRN2 binding by XTB domains. PMID:26779609
Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine. PMID:26779040
A network analysis of cofactor-protein interactions for analyzing associations between human nutrition and diseases. PMID:26777674
A novel BAP1 mutation is associated with melanocytic neoplasms and thyroid cancer. PMID:26774355
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer. PMID:26771841
Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin. PMID:26771485
ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression. PMID:26771237
Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. PMID:26771213
Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A 686. PMID:26760772
Identifying and functionally characterizing tissue-specific and ubiquitously expressed human lncRNAs. PMID:26760768
Human fallopian tube proteome shows high coverage of mesenchymal stem cells associated proteins. PMID:26759384
miR-185 mediates lung epithelial cell death after oxidative stress. PMID:26747785
Galectins are human milk glycan receptors. PMID:26747425
The 5300-year-old Helicobacter pylori genome of the Iceman. PMID:26744403
Pregnancy in a Patient With Primary Membranous Nephropathy and Circulating Anti-PLA2R Antibodies: A Case Report. PMID:26744127
A proteogenomic approach to understand splice isoform functions through sequence and expression-based computational modeling. PMID:26740460
Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. PMID:26736064
Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics. PMID:26732734
ChainRank, a chain prioritisation method for contextualisation of biological networks. PMID:26729273
New Colors for Histology: Optimized Bivariate Color Maps Increase Perceptual Contrast in Histological Images. PMID:26717571
TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. PMID:26701909
Forward Individualized Medicine from Personal Genomes to Interactomes. PMID:26696898
Meta-analysis of RNA-seq expression data across species, tissues and studies. PMID:26694591
The Urinary Bladder Transcriptome and Proteome Defined by Transcriptomics and Antibody-Based Profiling. PMID:26694548
Identification of significantly mutated regions across cancer types highlights a rich landscape of functional molecular alterations. PMID:26691984
Identification of epistatic interactions through genome-wide association studies in sporadic medullary and juvenile papillary thyroid carcinomas. PMID:26690675
Bioinformatics Mining and Modeling Methods for the Identification of Disease Mechanisms in Neurodegenerative Disorders. PMID:26690135
Fundamentals of protein interaction network mapping. PMID:26681426
Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins. PMID:26678612
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors. PMID:26675378
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. PMID:26673895
Rare copy number variants implicated in posterior urethral valves. PMID:26663319
Circulating protein synthesis rates reveal skeletal muscle proteome dynamics. PMID:26657858
Exome Sequencing Identifies Pathogenic and Modifier Mutations in a Child With Sporadic Dilated Cardiomyopathy. PMID:26656454
Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding. PMID:26651948
Integrating Diverse Types of Genomic Data to Identify Genes that Underlie Adverse Pregnancy Phenotypes. PMID:26641094
Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8. PMID:26637978
Phospholipase C-β1 Hypofunction in the Pathogenesis of Schizophrenia. PMID:26635636
Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer. PMID:26633560
Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants. PMID:26633466
Inhibition Profiling of Retroviral Protease Inhibitors Using an HIV-2 Modular System. PMID:26633459
MERAV: a tool for comparing gene expression across human tissues and cell types. PMID:26626150
Regulation of Murine Ovarian Epithelial Carcinoma by Vaccination against the Cytoplasmic Domain of Anti-Müllerian Hormone Receptor II. PMID:26618181
The Elusive Antifibrotic Macrophage. PMID:26618160
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response. PMID:26597527
Lynx: a knowledge base and an analytical workbench for integrative medicine. PMID:26590263
Developing Potential Candidates of Preclinical Preeclampsia. PMID:26580600
Oncogene-Induced Senescence in Pituitary Adenomas--an Immunohistochemical Study. PMID:26573928
Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila. PMID:26567182
Immunocapture strategies in translational proteomics. PMID:26558424
T-cell receptor gene therapy--ready to go viral? PMID:26548533
Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human. PMID:26545399
Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly. PMID:26538313
The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma. PMID:26526617
Germline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid Cancer. PMID:26522472
CAMUR: Knowledge extraction from RNA-seq cancer data through equivalent classification rules. PMID:26519501
Integrated interactions database: tissue-specific view of the human and model organism interactomes. PMID:26516188
NCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings. PMID:26516186
Multiclassifier combinatorial proteomics of organelle shadows at the example of mitochondria in chromatin data. PMID:26510496
Targeted Therapies in Liver Fibrosis: Combining the Best Parts of Platelet-Derived Growth Factor BB and Interferon Gamma. PMID:26501061
SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin. PMID:26497600
Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues. PMID:26496946
The potential clinical impact of the release of two drafts of the human proteome. PMID:26496066
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. PMID:26493500
Qualitative and Quantitative Protein Complex Prediction Through Proteome-Wide Simulations. PMID:26492574
Establishing the Role of PPARβ/δ in Carcinogenesis. PMID:26490384
An evidence-based knowledgebase of metastasis suppressors to identify key pathways relevant to cancer metastasis. PMID:26486520
Cell biology of the future: Nanometer-scale cellular cartography. PMID:26483557
Expression Atlas update--an integrated database of gene and protein expression in humans, animals and plants. PMID:26481351
Erythropoietin Stimulates Tumor Growth via EphB4. PMID:26481148
Tissue matrix arrays for high-throughput screening and systems analysis of cell function. PMID:26480475
The gut microbiota modulates host amino acid and glutathione metabolism in mice. PMID:26475342
Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver. PMID:26473164
The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer. PMID:26452038
The Hox cluster microRNA miR-615: a case study of intronic microRNA evolution. PMID:26451238
MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins. PMID:26450961
The cytotoxicity of the α1-adrenoceptor antagonist prazosin is linked to an endocytotic mechanism equivalent to transport-P. PMID:26449523
Exploring the potential of public proteomics data. PMID:26449181
HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators. PMID:26447468
Recent insights into the biological functions of liver fatty acid binding protein 1. PMID:26443794
Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins. PMID:26437229
Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue. PMID:26434764
MitoMiner v3.1, an update on the mitochondrial proteomics database. PMID:26432830
Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms. PMID:26431381
Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. PMID:26431332
MicroRNAs in placental health and disease. PMID:26428496
Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry. PMID:26417085
Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons. PMID:26416880
Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes. PMID:26406121
A cultured approach to canine urothelial carcinoma: molecular characterization of five cell lines. PMID:26401343
Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. PMID:26394276
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate. PMID:26388830
mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. PMID:26382858
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook. PMID:26377319
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC. PMID:26377184
'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. PMID:26377085
Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers. PMID:26374119
Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality. PMID:26352407
Human protein interaction networks across tissues and diseases. PMID:26347769
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B. PMID:26344709
Panorama of ancient metazoan macromolecular complexes. PMID:26344197
Prediction and validation of enzyme and transporter off-targets for metformin. PMID:26335661
Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal. PMID:26314964
Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis. PMID:26297835
Chromosome Y genetic variants: impact in animal models and on human disease. PMID:26286457
miR-126-3p Inhibits Thyroid Cancer Cell Growth and Metastasis, and Is Associated with Aggressive Thyroid Cancer. PMID:26244545
A Role for Low Density Lipoprotein Receptor-Related Protein 1 in the Cellular Uptake of Tissue Plasminogen Activator in the Lungs. PMID:26231141
Identification and Validation of Protein Biomarkers of Response to Neoadjuvant Platinum Chemotherapy in Muscle Invasive Urothelial Carcinoma. PMID:26230923
Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models. PMID:26224857
Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer. PMID:26222560
Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. PMID:26220980
STIM and ORAI proteins in the nervous system. PMID:26218135
APOL1 Kidney Disease Risk Variants: An Evolving Landscape. PMID:26215860
MI-PVT: A Tool for Visualizing the Chromosome-Centric Human Proteome. PMID:26204236
Mining Missing Membrane Proteins by High-pH Reverse-Phase StageTip Fractionation and Multiple Reaction Monitoring Mass Spectrometry. PMID:26202522
Mitochondrial genomes are retained by selective constraints on protein targeting. PMID:26195779
Structural Bioinformatics Inspection of neXtProt PE5 Proteins in the Human Proteome. PMID:26193931
Structure alignment of membrane proteins: Accuracy of available tools and a consensus strategy. PMID:26178143
Automated Analysis and Classification of Histological Tissue Features by Multi-Dimensional Microscopic Molecular Profiling. PMID:26176839
Implications of pleiotropy: challenges and opportunities for mining Big Data in biomedicine. PMID:26175753
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. PMID:26168014
THOC2 Mutations Implicate mRNA-Export Pathway in X-Linked Intellectual Disability. PMID:26166480
Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells. PMID:26164207
Pigment epithelium-derived factor as a multifunctional regulator of wound healing. PMID:26163443
The extracellular matrix: Tools and insights for the "omics" era. PMID:26163349
Context-Specific Metabolic Model Extraction Based on Regularized Least Squares Optimization. PMID:26158726
Comprehensive comparison of large-scale tissue expression datasets. PMID:26157623
Matricellular proteins of the Cyr61/CTGF/NOV (CCN) family and the nervous system. PMID:26157362
Metrics for the Human Proteome Project 2015: Progress on the Human Proteome and Guidelines for High-Confidence Protein Identification. PMID:26155816
Association between cell cycle gene transcription and tumor size in oral squamous cell carcinoma. PMID:26152289
Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry. PMID:26150155
Post-translational modifications of the cardiac proteome in diabetes and heart failure. PMID:26140508
Personalized medicine going precise: from genomics to microbiomics. PMID:26129865
OCT1 and imatinib transport in CML: is it clinically relevant? PMID:26122430
Complementing tissue characterization by integrating transcriptome profiling from the Human Protein Atlas and from the FANTOM5 consortium. PMID:26117540
Evolutionary trends and functional anatomy of the human expanded autophagy network. PMID:26103419
Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila. PMID:26098872
Extensive rewiring of epithelial-stromal co-expression networks in breast cancer. PMID:26087699
Defining the Human Brain Proteome Using Transcriptomics and Antibody-Based Profiling with a Focus on the Cerebral Cortex. PMID:26076492
The Levels of a Universally Conserved tRNA Modification Regulate Cell Growth. PMID:26063805
Alternatively Spliced Homologous Exons Have Ancient Origins and Are Highly Expressed at the Protein Level. PMID:26061177
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells. PMID:26022688
DeAnnCNV: a tool for online detection and annotation of copy number variations from whole-exome sequencing data. PMID:26013811
MyProteinNet: build up-to-date protein interaction networks for organisms, tissues and user-defined contexts. PMID:25990735
Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. PMID:25979344
Enzyme-instructed self-assembly: a multistep process for potential cancer therapy. PMID:25933032
Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer. PMID:25903835
Manganese homeostasis and utilization in pathogenic bacteria. PMID:25898914
Psoriatic arthritis under a proteomic spotlight: application of novel technologies to advance diagnosis and management. PMID:25895652
Systems medicine: evolution of systems biology from bench to bedside. PMID:25891169
Assessing the impact of mutations found in next generation sequencing data over human signaling pathways. PMID:25883139
Modelling the effect of SPION size in a stent assisted magnetic drug targeting system with interparticle interactions. PMID:25815370
Role of E2-Ub-conjugating enzymes during skeletal muscle atrophy. PMID:25805999
Affinity proteomics to study endogenous protein complexes: pointers, pitfalls, preferences and perspectives. PMID:25757543
Gene expression: spatial characterization of proteomes. PMID:25668785 -
A pathology atlas of the human cancer transcriptome
PubMed citations: 1189.
1189 articles citing: A pathology atlas of the human cancer transcriptome
Gene Identification and Potential Drug Therapy for Drug-Resistant Melanoma with Bioinformatics and Deep Learning Technology. PMID:35915735
BCHE as a Prognostic Biomarker in Endometrial Cancer and Its Correlation with Immunity. PMID:35915658
Exploration and validation of metastasis-associated genes for skin cutaneous melanoma. PMID:35906389
CC chemokine receptor 7 promotes macrophage recruitment and induces M2-polarization through CC chemokine ligand 19&21 in oral squamous cell carcinoma. PMID:35904690
A comprehensive analysis of ncRNA-mediated interactions reveals potential prognostic biomarkers in prostate adenocarcinoma. PMID:35891787
Differential Transcriptomic Profiles Following Stimulation with Lipopolysaccharide in Intestinal Organoids from Dogs with Inflammatory Bowel Disease and Intestinal Mast Cell Tumor. PMID:35884586
Deciphering Prognostic Value of TTN and Its Correlation With Immune Infiltration in Lung Adenocarcinoma. PMID:35875159
Constraint-Based Reconstruction and Analyses of Metabolic Models: Open-Source Python Tools and Applications to Cancer. PMID:35875150
The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma. PMID:35875075
Expression Patterns of Necroptosis-Related Genes: Predicting Prognosis and Immunotherapeutic Effects in Cutaneous Melanoma. PMID:35874627
Bidirectional Relationship Between Cancer and Heart Failure: Insights on Circulating Biomarkers. PMID:35872912
SMOC2 promotes an epithelial-mesenchymal transition and a pro-metastatic phenotype in epithelial cells of renal cell carcinoma origin. PMID:35869056
Identification of BST2 Contributing to the Development of Glioblastoma Based on Bioinformatics Analysis. PMID:35865015
GRAMD1A Is a Biomarker of Kidney Renal Clear Cell Carcinoma and Is Associated with Immune Infiltration in the Tumour Microenvironment. PMID:35860689
RAD21 Confers Poor Prognosis and Affects Ovarian Cancer Sensitivity to Poly(ADP-Ribose)Polymerase Inhibitors Through DNA Damage Repair. PMID:35860572
APOA1 mRNA and protein in kidney renal clear cell carcinoma correlate with the disease outcome. PMID:35858961
Identification of a Prognostic Transcriptome Signature for Hepatocellular Carcinoma with Lymph Node Metastasis. PMID:35847584
What are housekeeping genes? PMID:35830477
Investigating the impact of RNA integrity variation on the transcriptome of human leukemic cells. PMID:35814037
RELA-induced MiR-21 Exerts Oncogenic Effects on PDAC via Targeting of ARHGAP24. PMID:35812178
Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells. PMID:35806349
MFAP4-Mediated Effects in Elastic Fiber Homeostasis, Integrin Signaling and Cancer, and Its Role in Teleost Fish. PMID:35805199
A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic Targets. PMID:35791393
High expression of N-type calcium channel indicates a favorable prognosis in gliomas. PMID:35777045
Thymoquinone upregulates IL17RD in controlling the growth and metastasis of triple negative breast cancer cells in vitro. PMID:35761256
CircRNA circ_0006156 inhibits the metastasis of prostate cancer by blocking the ubiquitination of S100A9. PMID:35760899
Roles of Cadherin2 in Thyroid Cancer. PMID:35756646
Prognostic Implication and Immunological Role of PSMD2 in Lung Adenocarcinoma. PMID:35754829
TMED2/9/10 Serve as Biomarkers for Poor Prognosis in Head and Neck Squamous Carcinoma. PMID:35754792
Impact of Zinc Transport Mechanisms on Embryonic and Brain Development. PMID:35745255
Comprehensive Integrated Single-Cell Whole Transcriptome Analysis Revealed the p-EMT Tumor Cells-CAFs Communication in Oral Squamous Cell Carcinoma. PMID:35742914
Identification and clinical validation of NUSAP1 as a novel prognostic biomarker in ovarian cancer. PMID:35739489
Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ. PMID:35737091
Expression of GOT2 Is Epigenetically Regulated by DNA Methylation and Correlates with Immune Infiltrates in Clear-Cell Renal Cell Carcinoma. PMID:35735610
A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling. PMID:35729113
New classification for advanced breast cancer patients experiencing disease progression during salvage treatment: a single-center retrospective cohort study. PMID:35722367
The Correlation Between Immune Invasion and SARS-COV-2 Entry Protein ADAM17 in Cancer Patients by Bioinformatic Analysis. PMID:35720350
Comprehensive Analyses of MELK-Associated ceRNA Networks Reveal a Potential Biomarker for Predicting Poor Prognosis and Immunotherapy Efficacy in Hepatocellular Carcinoma. PMID:35693941
Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients. PMID:35693094
Development and Validation of a Novel PPAR Signaling Pathway-Related Predictive Model to Predict Prognosis in Breast Cancer. PMID:35692496
Role of Nucleolin in Endometrial Precancerous Hyperplasia and Carcinogenesis: Ex Vivo and In Silico Study. PMID:35682908
Changes in the Transcriptome Caused by Mutations in the Ribosomal Protein uS10 Associated with a Predisposition to Colorectal Cancer. PMID:35682850
Solute carrier family 2 members 1 and 2 as prognostic biomarkers in hepatocellular carcinoma associated with immune infiltration. PMID:35665115
Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression. PMID:35664705
NAP1L1 Functions as a Novel Prognostic Biomarker Associated With Macrophages and Promotes Tumor Progression by Influencing the Wnt/β-Catenin Pathway in Hepatocellular Carcinoma. PMID:35664324
Prognostic value of disseminated tumor cells in unresectable pancreatic ductal adenocarcinoma: a prospective observational study. PMID:35659265
DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD. PMID:35655269
BARD1 mystery: tumor suppressors are cancer susceptibility genes. PMID:35650591
Cold atmospheric plasmas target breast cancer stemness via modulating AQP3-19Y mediated AQP3-5K and FOXO1 K48-ubiquitination. PMID:35637961
Identifying tumor cells at the single-cell level using machine learning. PMID:35637521
Pyroptosis-related genes regulate proliferation and invasion of pancreatic cancer and serve as the prognostic signature for modeling patient survival. PMID:35633405
Wnt/β-Catenin Signalling and Its Cofactor BCL9L Have an Oncogenic Effect in Bladder Cancer Cells. PMID:35628130
The Overexpression of Fibronectin 1 Promotes Cancer Progression and Associated with M2 Macrophages Polarization in Head and Neck Squamous Cell Carcinoma Patients. PMID:35607361
CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4-Fatty Acid β-Oxidation Pathway. PMID:35603967
Low CRIM1 Levels Predict Poor Prognosis in Breast Cancer Patients. PMID:35600360
A precision medicine approach to metabolic therapy for breast cancer in mice. PMID:35595952
Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking. PMID:35595947
RET in breast cancer: pathogenic implications and mechanisms of drug resistance. PMID:35582269
Tumor immune-gene expression profiles and peripheral immune phenotypes associated with clinical outcomes of locally advanced pancreatic cancer following FOLFIRINOX. PMID:35576696
Comprehensive analyses reveal the carcinogenic and immunological roles of ANLN in human cancers. PMID:35568883
Transcriptome profiling and proteomic validation reveals targets of the androgen receptor signaling in the BT-474 breast cancer cell line. PMID:35568821
Extrachromosomal Circular DNA from TCGA Tumors Is Generated from Common Genomic Loci, Is Characterized by Self-Homology and DNA Motifs near Circle Breakpoints. PMID:35565439
A Novel Machine Learning 13-Gene Signature: Improving Risk Analysis and Survival Prediction for Clear Cell Renal Cell Carcinoma Patients. PMID:35565241
Updated Functional Roles of NAMPT in Carcinogenesis and Therapeutic Niches. PMID:35565188
In Silico, In Vitro, and Clinical Investigations of Cathepsin B and Stefin A mRNA Expression and a Correlation Analysis in Kidney Cancer. PMID:35563761
Innovations in Genomics and Big Data Analytics for Personalized Medicine and Health Care: A Review. PMID:35563034
Whole exome sequencing identifies novel germline variants of SLC15A4 gene as potentially cancer predisposing in familial colorectal cancer. PMID:35562597
Pyroptosis-Related Patterns Predict Tumor Immune Landscape and Immunotherapy Response in Bladder Cancer. PMID:35558555
Integrative Analysis Constructs an Extracellular Matrix-Associated Gene Signature for the Prediction of Survival and Tumor Immunity in Lung Adenocarcinoma. PMID:35557945
Hierarchical network analysis of co-occurring bioentities in literature. PMID:35550589
SKA3 is a prognostic biomarker and associated with immune infiltration in bladder cancer. PMID:35546682
PCMT1 Is a Potential Prognostic Biomarker and Is Correlated with Immune Infiltrates in Breast Cancer. PMID:35535040
Upregulation of PKN1 as a Prognosis Biomarker for Endometrial Cancer. PMID:35533253
NIBAN1, Exploring its Roles in Cell Survival Under Stress Context. PMID:35517496
Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer. PMID:35508649
The prognostic miR-532-5p-correlated ceRNA-mediated lipid droplet accumulation drives nodal metastasis of cervical cancer. PMID:35499057
Construction and Validation of Angiogenesis-Related Prognostic Risk Signature to Facilitate Survival Prediction and Biomarker Excavation of Breast Cancer Patients. PMID:35498539
The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor. PMID:35495622
Individualized pathway activity algorithm identifies oncogenic pathways in pan-cancer analysis. PMID:35487057
Construction and validation of a robust ferroptosis-associated gene signature predictive of prognosis in lung adenocarcinoma. PMID:35482981
CpG Site-Specific Methylation-Modulated Divergent Expression of PRSS3 Transcript Variants Facilitates Nongenetic Intratumor Heterogeneity in Human Hepatocellular Carcinoma. PMID:35480112
The Dysregulation of SOX Family Correlates with DNA Methylation and Immune Microenvironment Characteristics to Predict Prognosis in Hepatocellular Carcinoma. PMID:35465267
HUS1 as a Potential Therapeutic Target in Urothelial Cancer. PMID:35456300
A Method for Unsupervised Semi-Quantification of Inmunohistochemical Staining with Beta Divergences. PMID:35455209
Integrated In Silico Analyses Identify PUF60 and SF3A3 as New Spliceosome-Related Breast Cancer RNA-Binding Proteins. PMID:35453681
Triazole Modified Tetraiodothyroacetic Acid Conjugated to Polyethylene Glycol, a Thyrointegrin αvβ3 Antagonist as a Radio- and Chemo-Sensitizer in Pancreatic Cancer. PMID:35453545
Immune-related biomarkers shared by inflammatory bowel disease and liver cancer. PMID:35452485
USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma. PMID:35449157
Effects of Anticancer Agent P-bi-TAT on Gene Expression Link the Integrin Thyroid Hormone Receptor to Expression of Stemness and Energy Metabolism Genes in Cancer Cells. PMID:35448512
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments. PMID:35447093
Identification of Immune-Related Key Genes as Potential Diagnostic Biomarkers of Sepsis in Children. PMID:35444449
Comprehensive Analysis on Prognosis and Immune Infiltration of Lysyl Oxidase Family Members in Pancreatic Adenocarcinoma With Experimental Verification. PMID:35433829
Major Vault Protein (MVP) Associated With BRAF V600E Mutation Is an Immune Microenvironment-Related Biomarker Promoting the Progression of Papillary Thyroid Cancer via MAPK/ERK and PI3K/AKT Pathways. PMID:35433709
NUSAP1 Could be a Potential Target for Preventing NAFLD Progression to Liver Cancer. PMID:35431924
COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2. PMID:35414771
Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells. PMID:35414100
Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. PMID:35409174
Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer. PMID:35406529
Unravelling Prostate Cancer Heterogeneity Using Spatial Approaches to Lipidomics and Transcriptomics. PMID:35406474
Single-Cell Transcriptome Analysis Reveals the Role of Pancreatic Secretome in COVID-19 Associated Multi-organ Dysfunctions. PMID:35394619
Physical and functional interactome atlas of human receptor tyrosine kinases. PMID:35384245
NRF3 Decreases during Melanoma Carcinogenesis and Is an Independent Prognostic Marker in Melanoma. PMID:35378827
Study on the role of transcription factor SPI1 in the development of glioma. PMID:35361282
Identification of Pathologic and Prognostic Genes in Prostate Cancer Based on Database Mining. PMID:35360870
Molecular Characteristics and Prognostic Role of MFAP2 in Stomach Adenocarcinoma. PMID:35356627
Genome-wide identification and analysis of prognostic features in human cancers. PMID:35354049
The Impact of ACEs on BMI: An Investigation of the Genotype-Environment Effects of BMI. PMID:35342390
Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach. PMID:35339898
GLUT3/SLC2A3 Is an Endogenous Marker of Hypoxia in Prostate Cancer Cell Lines and Patient-Derived Xenograft Tumors. PMID:35328229
A Gene Co-Expression Network-Based Drug Repositioning Approach Identifies Candidates for Treatment of Hepatocellular Carcinoma. PMID:35326724
Systematic analysis of the expression and prognostic value of ITPR1 and correlation with tumor infiltrating immune cells in breast cancer. PMID:35313846
Designed hybrid anticancer nuclear-localized peptide inhibits aggressive cancer cell proliferation. PMID:35308028
Knockdown of RSPH14 inhibits proliferation, migration, and invasion and promotes apoptosis of hepatocellular carcinoma via RelA. PMID:35305640
Roles of Pyroptosis-Related Gene Signature in Prediction of Endometrial Cancer Outcomes. PMID:35299842
RB1 Is an Immune-Related Prognostic Biomarker for Ovarian Cancer. PMID:35299734
A multi-omics-based investigation of the immunological and prognostic impact of necroptosis-related genes in patients with hepatocellular carcinoma. PMID:35293027
PCR-based profiling of transcription factor activity in vivo by a virus-based reporter battery. PMID:35281741
Energy Metabolism-Related Gene Prognostic Index Predicts Biochemical Recurrence for Patients With Prostate Cancer Undergoing Radical Prostatectomy. PMID:35280985
NDF is a transcription factor that stimulates elongation by RNA polymerase II. PMID:35273076
Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 Severity. PMID:35251002
Abnormal expression and the significant prognostic value of aquaporins in clear cell renal cell carcinoma. PMID:35245343
Insulin and cancer: a tangled web. PMID:35244142
Promoter/enhancer-based controllability of regulatory networks. PMID:35241702
A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing. PMID:35241646
Molecular Patterns Based on Immunogenomic Signatures Stratify the Prognosis of Colon Cancer. PMID:35237578
A New Prognostic Risk Score: Based on the Analysis of Autophagy-Related Genes and Renal Cell Carcinoma. PMID:35237298
Complement Factor H in cSCC: Evidence of a Link Between Sun Exposure and Immunosuppression in Skin Cancer Progression. PMID:35223500
High Expression of PLAGL2 is Associated With Poor Prognosis in High-Grade Glioma. PMID:35222518
A Novel Role of Arrhythmia-Related Gene KCNQ1 Revealed by Multi-Omic Analysis: Theragnostic Value and Potential Mechanisms in Lung Adenocarcinoma. PMID:35216393
A hydrodynamic instability drives protein droplet formation on microtubules to nucleate branches. PMID:35211183
Computational Models for Clinical Applications in Personalized Medicine-Guidelines and Recommendations for Data Integration and Model Validation. PMID:35207655
Repair-Assisted Damage Detection Reveals Biological Disparities in Prostate Cancer between African Americans and European Americans. PMID:35205762
A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors. PMID:35205150
Molecular Signature of Tumor-Associated High Endothelial Venules That Can Predict Breast Cancer Survival. PMID:35201289
A Second-Generation Nanoluc-IL27 Fusion Cytokine for Targeted-Gene-Therapy Applications. PMID:35200430
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer. PMID:35197278
[Web-based gene expression analysis-paving the way to decode healthy and diseased ocular tissue]. PMID:35194679
Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment. PMID:35192545
The Role of Muscle Ring Finger-1 (MuRF1), MuRF2, MuRF3, and Atrogin-1 on Bone Microarchitecture In Vivo. PMID:35191000
A Comprehensive Prognostic Analysis of POLD1 in Hepatocellular Carcinoma. PMID:35189839
A robust gene expression signature for NASH in liver expression data. PMID:35173224
Exploring ALDH2 expression and immune infiltration in HNSC and its correlation of prognosis with gender or alcohol intake. PMID:35169188
Antibody Conjugated PLGA Nanocarriers and Superparmagnetic Nanoparticles for Targeted Delivery of Oxaliplatin to Cells from Colorectal Carcinoma. PMID:35163122
Targeting GPCRs and Their Signaling as a Therapeutic Option in Melanoma. PMID:35158973
Rlip Depletion Alters Oncogene Transcription at Multiple Distinct Regulatory Levels. PMID:35158795
Identification of tumor microenvironment-based genes associated with acquired resistance to EGFR Tyrosine Kinase Inhibitor in Lung Adenocarcinoma. PMID:35154456
Identification of a Novel Nomogram to Predict Progression Based on the Circadian Clock and Insights Into the Tumor Immune Microenvironment in Prostate Cancer. PMID:35154101
RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells. PMID:35143476
LncPep: A Resource of Translational Evidences for lncRNAs. PMID:35141219
The Multi-Omics Analysis of Key Genes Regulating EGFR-TKI Resistance, Immune Infiltration, SCLC Transformation in EGFR-Mutant NSCLC. PMID:35140497
CTCFL regulates the PI3K-Akt pathway and it is a target for personalized ovarian cancer therapy. PMID:35132075
Systems-based approaches to study immunometabolism. PMID:35121805
NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer. PMID:35121782
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. PMID:35120601
Somatic mutations in collagens are associated with a distinct tumor environment and overall survival in gastric cancer. PMID:35120467
A comprehensive analysis of the expression and regulation network of lymphocyte-specific protein tyrosine kinase in breast cancer. PMID:35116477
LCN2 as a Potential Diagnostic Biomarker for Ulcerative Colitis-Associated Carcinogenesis Related to Disease Duration. PMID:35111677
Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy. PMID:35107989
ZNF146/OZF and ZNF507 target LINE-1 sequences. PMID:35100360
Meta-imputation of transcriptome from genotypes across multiple datasets by leveraging publicly available summary-level data. PMID:35100255
Novel Classes and Evolutionary Turnover of Histone H2B Variants in the Mammalian Germline. PMID:35099534
Decreased CDKL2 Expression in Clear Cell Renal Cell Carcinoma Predicts Worse Overall Survival. PMID:35096961
The analysis of N6-methyladenosine regulators impacting the immune infiltration in clear cell renal cell carcinoma. PMID:35092501
Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury. PMID:35091838
Integrin-linked kinase (ILK): the known vs. the unknown and perspectives. PMID:35089438
The Age-Specific Features and Clinical Significance of NRF2 and MAPK10 Expression in HCC Patients. PMID:35082522
Comprehensive analysis of prognostic value and immune infiltration of calpains in pancreatic cancer. PMID:35070391
Promoter Methylation-Mediated NPTX2 Silencing Promotes Tumor Growth in Human Prostate Cancer. PMID:35069913
Overexpression of Parkin in clear cell renal cell carcinoma decreases tumor aggressiveness by regulating CKS2 levels. PMID:35059737
SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells. PMID:35055098
Telomere and Telomerase-Associated Proteins in Endometrial Carcinogenesis and Cancer-Associated Survival. PMID:35054812
A Selective Small-Molecule c-Myc Degrader Potently Regresses Lethal c-Myc Overexpressing Tumors. PMID:35048559
Multi-Omics Analysis for Transcriptional Regulation of Immune-Related Targets Using Epigenetic Data: A New Research Direction. PMID:35046932
Identification of PDCD1 and PDCD1LG2 as Prognostic Biomarkers and Associated with Immune Infiltration in Hepatocellular Carcinoma. PMID:35046705
Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction. PMID:35046386
The Mlc1 Promoter Directs Müller Cell-specific Gene Expression in the Retina. PMID:35040915
Association between Arsenic Level, Gene Expression in Asian Population, and In Vitro Carcinogenic Bladder Tumor. PMID:35039759
A Bioinformatic Analysis of Immune-Related Prognostic Genes in Clear Cell Renal Cell Carcinoma Based on TCGA and GEO Databases. PMID:35035230
Loss of circadian gene Timeless induces EMT and tumor progression in colorectal cancer via Zeb1-dependent mechanism. PMID:35034102
The role of metabolic ecosystem in cancer progression - metabolic plasticity and mTOR hyperactivity in tumor tissues. PMID:35029792
ARID1A Is a Prognostic Biomarker and Associated with Immune Infiltrates in Hepatocellular Carcinoma. PMID:35028302
Identification of long non-coding RNAs and RNA binding proteins in breast cancer subtypes. PMID:35027621
Activated leukocyte cell adhesion molecule (ALCAM)/CD166 in pancreatic cancer, a pivotal link to clinical outcome and vascular embolism. PMID:35018233
Topographic mapping of the glioblastoma proteome reveals a triple-axis model of intra-tumoral heterogeneity. PMID:35013227
Bak and Bcl-xL Participate in Regulating Sensitivity of Solid Tumor Derived Cell Lines to Mcl-1 Inhibitors. PMID:35008345
Comprehensive Analysis of the Prognostic Values of the TRIM Family in Hepatocellular Carcinoma. PMID:35004288
Physical Interactions With Bacteria and Protozoan Parasites Establish the Scavenger Receptor SSC4D as a Broad-Spectrum Pattern Recognition Receptor. PMID:35003072
Cytochrome b561 Serves as a Potential Prognostic Biomarker and Target for Breast Cancer. PMID:35002301
Pyroptosis regulators exert crucial functions in prognosis, progression and immune microenvironment of pancreatic adenocarcinoma: a bioinformatic and in vitro research. PMID:35000541
Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models. PMID:34997121
Development of Biomarker Signatures Associated with Anoikis to Predict Prognosis in Endometrial Carcinoma Patients. PMID:34992654
Identification of ubiquitinated substrate proteins and their gene expression patterns in lung adenocarcinoma. PMID:34988201
Genome-wide analysis of genetic predisposition to common polygenic cancers. PMID:34981446
Significance of CD47 and Its Association With Tumor Immune Microenvironment Heterogeneity in Ovarian Cancer. PMID:34966389
Functional analysis of the 1p34.3 risk locus implicates GNL2 in high-grade serous ovarian cancer. PMID:34965383
Inositol Phosphates and Retroviral Assembly: A Cellular Perspective. PMID:34960784
Glycolysis Changes the Microenvironment and Therapeutic Response Under the Driver of Gene Mutation in Esophageal Adenocarcinoma. PMID:34956314
A β-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer. PMID:34954189
Multi-Omics Reveal the Immunological Role and the Theragnostic Value of miR-216a/GDF15 Axis in Human Colon Adenocarcinoma. PMID:34948431
Profiling Glioblastoma Cases with an Expression of DCX, OLIG2 and NES. PMID:34948016
Targeting the Interplay between Cancer Metabolic Reprogramming and Cell Death Pathways as a Viable Therapeutic Path. PMID:34944758
A Gene-Based Machine Learning Classifier Associated to the Colorectal Adenoma-Carcinoma Sequence. PMID:34944753
Reduction of Rapid Proliferating Tumour Cell Lines by Inhibition of the Specific Glycine Transporter GLYT1. PMID:34944586
Evaluation of Placental Alkaline Phosphatase Expression as A Potential Target of Solid Tumors Immunotherapy by Using Gene and Protein Expression Repositories. PMID:34939766
Intra-Tumoral Expression of SLC7A11 Is Associated with Immune Microenvironment, Drug Resistance, and Prognosis in Cancers: A Pan-Cancer Analysis. PMID:34938318
Prognostic biomarker SMARCC1 and its association with immune infiltrates in hepatocellular carcinoma. PMID:34937564
Prognostic Implications and Immune Infiltration Analysis of ALDOA in Lung Adenocarcinoma. PMID:34925439
Subcellular Transcriptomics and Proteomics: A Comparative Methods Review. PMID:34922010
KRAS mutation-independent downregulation of MAPK/PI3K signaling in colorectal cancer. PMID:34919787
NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis. PMID:34919052
Epigenetic loss of heterogeneity from low to high grade localized prostate tumours. PMID:34911933
How Times Have Changed! A Cornucopia of Antigens for Membranous Nephropathy. PMID:34899763
Pharmacological Activation of cGAS for Cancer Immunotherapy. PMID:34899704
Serum Sorbitol Dehydrogenase as a Novel Prognostic Factor for Hepatocellular Carcinoma after Surgical Resection. PMID:34885252
Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity. PMID:34885241
Molecular Activation of the Kv11.1 Channel Reprograms EMT in Colon Cancer by Inhibiting TGFβ Signaling via Activation of Calcineurin. PMID:34885136
Comprehensive Analysis of LPCATs Highlights the Prognostic and Immunological Values of LPCAT1/4 in Hepatocellular Carcinoma. PMID:34876845
Characterization of the GATA Transcription Factor Family and Exploration of Their Relevance to Immune Infiltration and Tumor Microenvironment in Pancreatic Cancer. PMID:34876843
Epstein-Barr Virus+ B Cells in Breast Cancer Immune Response: A Case Report. PMID:34868006
Therapeutic implications of cancer gene amplifications without mRNA overexpression: silence may not be golden. PMID:34857015
Structure based prediction of a novel GPR120 antagonist based on pharmacophore screening and molecular dynamics simulations. PMID:34849208
Identifying the Predictive Role of Oxidative Stress Genes in the Prognosis of Glioma Patients. PMID:34836934
Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers. PMID:34830760
PODNL1 Methylation Serves as a Prognostic Biomarker and Associates with Immune Cell Infiltration and Immune Checkpoint Blockade Response in Lower-Grade Glioma. PMID:34830454
Pathway-Based Personalized Analysis of Pan-Cancer Transcriptomic Data. PMID:34829731
Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies. PMID:34829671
The Role of CDK4 in the Pathogenesis of Pancreatic Cancer. PMID:34828525
The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. PMID:34822775
Feedback Loop Regulation between Pim Kinases and Tax Keeps Human T-Cell Leukemia Virus Type 1 Viral Replication in Check. PMID:34818069
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging. PMID:34811556
Construction of a circular RNA-microRNA-messenger RNA regulatory network of hsa_circ_0043256 in lung cancer by integrated analysis. PMID:34806315
Overexpressing IFITM family genes predict poor prognosis in kidney renal clear cell carcinoma. PMID:34804826
Methionine synthase supports tumour tetrahydrofolate pools. PMID:34799699
A Cholesterol Homeostasis-Related Gene Signature Predicts Prognosis of Endometrial Cancer and Correlates With Immune Infiltration. PMID:34790227
Knockdown of Oligosaccharyltransferase Subunit Ribophorin 1 Induces Endoplasmic-Reticulum-Stress-Dependent Cell Apoptosis in Breast Cancer. PMID:34778038
Genome-wide association study of hospitalized COVID-19 patients in the United Arab Emirates. PMID:34775353
STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker. PMID:34772410
A Prostate Cancer Proteomics Database for SWATH-MS Based Protein Quantification. PMID:34771740
Selective Microfluidic Capture and Detection of Prostate Cancer Cells from Urine without Digital Rectal Examination. PMID:34771706
Prognostic biomarkers for predicting papillary thyroid carcinoma patients at high risk using nine genes of apoptotic pathway. PMID:34767591
Integrated bioinformatics analysis reveals dynamic candidate genes and signaling pathways involved in the progression and prognosis of diffuse large B-cell lymphoma. PMID:34760386
The Oncogenic Role and Immune Infiltration for CARM1 Identified by Pancancer Analysis. PMID:34745258
Low Cell Number Proteomic Analysis Using In-Cell Protease Digests Reveals a Robust Signature for Cell Cycle State Classification. PMID:34742921
Transposable elements that have recently been mobile in the human genome. PMID:34732136
p53/FBXL20 axis negatively regulates the protein stability of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase. PMID:34731788
Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis. PMID:34731617
A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease. PMID:34712920
The correlation of WDR76 expression with survival outcomes and immune infiltrates in lung adenocarcinoma. PMID:34707943
Analysing a Novel RNA-Binding-Protein-Related Prognostic Signature Highly Expressed in Breast Cancer. PMID:34707800
The unfolded protein response links tumor aneuploidy to local immune dysregulation. PMID:34698427
NUAK Kinases: Brain-Ovary Axis. PMID:34685740
The Intersection of Purine and Mitochondrial Metabolism in Cancer. PMID:34685583
The Role of Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 in the Pathogenesis of Human Cancer. PMID:34681622
Identification of Five Hub Genes as Key Prognostic Biomarkers in Liver Cancer via Integrated Bioinformatics Analysis. PMID:34681056
The Clinical and Theranostic Values of Activated Leukocyte Cell Adhesion Molecule (ALCAM)/CD166 in Human Solid Cancers. PMID:34680335
MiRNA-424-5p Suppresses Proliferation, Migration, and Invasion of Clear Cell Renal Cell Carcinoma and Attenuates Expression of O-GlcNAc-Transferase. PMID:34680309
Changes in Protein Structural Motifs upon Post-Translational Modification in Kidney Cancer. PMID:34679534
Study of Clinical Predictive Value and Immune Characterization of SLFN11 in Clear Cell Renal Cell Carcinoma. PMID:34675634
An Autophagy-Related Long Non-Coding RNA Prognostic Signature for Patients with Lung Squamous Carcinoma Based on Bioinformatics Analysis. PMID:34675625
Pan-cancer analysis of pathway-based gene expression pattern at the individual level reveals biomarkers of clinical prognosis. PMID:34671755
The Role of ARID1A in Tumors: Tumor Initiation or Tumor Suppression? PMID:34671561
Bioinformatics Analysis Reveals MCM3 as an Important Prognostic Marker in Cervical Cancer. PMID:34671420
COVID-19 disease and malignant cancers: The impact for the furin gene expression in susceptibility to SARS-CoV-2. PMID:34671211
Deciphering the link between Diabetes mellitus and SARS-CoV-2 infection through differential targeting of microRNAs in the human pancreas. PMID:34669152
MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling. PMID:34663908
CD161, a promising Immune Checkpoint, correlates with Patient Prognosis: A Pan-cancer Analysis. PMID:34659549
Annotation depth confounds direct comparison of gene expression across species. PMID:34654362
Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma. PMID:34649520
Meta-Analysis illustrates possible role of lipopolysaccharide (LPS)-induced tissue injury in nasopharyngeal carcinoma (NPC) pathogenesis. PMID:34648530
Clinical and Tumor Characteristics of Patients with High Serum Levels of Growth Differentiation Factor 15 in Advanced Pancreatic Cancer. PMID:34638326
High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma. PMID:34635011
The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events. PMID:34633481
Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer. PMID:34628286
Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma. PMID:34621750
Exosomal hsa-miR-21-5p is a biomarker for breast cancer diagnosis. PMID:34616615
Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels. PMID:34613776
Landscape of prognostic signatures and immunogenomics of the AXL/GAS6 axis in renal cell carcinoma. PMID:34611307
RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis. PMID:34611297
Determinants of renal cell carcinoma invasion and metastatic competence. PMID:34608135
SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma. PMID:34604392
A New Survival Model Based on ADAMTSs for Prognostic Prediction in Clear Cell Renal Cell Carcinoma. PMID:34603444
Identification of new reference genes with stable expression patterns for gene expression studies using human cancer and normal cell lines. PMID:34593877
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity. PMID:34591642
Interpretation of cancer mutations using a multiscale map of protein systems. PMID:34591613
Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer. PMID:34590601
t(4;12)(q12;p13) ETV6-rearranged AML without eosinophilia does not involve PDGFRA: relevance for imatinib insensitivity. PMID:34587239
Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae. PMID:34586382
Impact of depression and stress on placental DNA methylation in ethnically diverse pregnant women. PMID:34585950
Characterization of Circulating IL-7R Positive Cell Populations for Early Detection of Pancreatic Ductal Adenocarcinoma. PMID:34575268
Vorinostat (SAHA) and Breast Cancer: An Overview. PMID:34572928
Functional Characteristics and Regulated Expression of Alternatively Spliced Tissue Factor: An Update. PMID:34572880
Genome Scale Modeling to Study the Metabolic Competition between Cells in the Tumor Microenvironment. PMID:34572839
Deletion of NEMO Inhibits EMT and Reduces Metastasis in KPC Mice. PMID:34572768
Construction of circRNA-based ceRNA network and its prognosis-associated subnet of clear cell renal cell carcinoma. PMID:34569727
DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. PMID:34568799
Chromobox Homolog 8 (CBX8) in Human Tumor Carcinogenesis and Prognosis: A Pancancer Analysis Using Multiple Databases. PMID:34567093
Structural basis and regulation of the reductive stress response. PMID:34562363
Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome. PMID:34561431
Nucleolar protein 6 promotes cell proliferation and acts as a potential novel prognostic marker for hepatocellular carcinoma. PMID:34561331
Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma. PMID:34556750
RAF1 amplification drives a subset of bladder tumors and confers sensitivity to MAPK-directed therapeutics. PMID:34554931
Gene Expression-Assisted Cancer Prediction Techniques. PMID:34545300
Physical and Functional Interaction of Mitochondrial Single-Stranded DNA-Binding Protein and the Catalytic Subunit of DNA Polymerase Gamma. PMID:34539752
The expression and prognostic value of REXO4 in hepatocellular carcinoma. PMID:34532121
PUM1 represses CDKN1B translation and contributes to prostate cancer progression. PMID:34531333
Deep proteome profiling of human mammary epithelia at lineage and age resolution. PMID:34522866
TRIM25: A central factor in breast cancer. PMID:34513598
ESPL1 Is a Novel Prognostic Biomarker Associated With the Malignant Features of Glioma. PMID:34512713
SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pathway. PMID:34509929
Differential whole-genome doubling and homologous recombination deficiencies across breast cancer subtypes from the Taiwanese population. PMID:34504292
The Expression Profiles and Deregulation of UDP-Glycosyltransferase (UGT) Genes in Human Cancers and Their Association with Clinical Outcomes. PMID:34503303
Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43266-283 in Glioblastoma Stem Cells. PMID:34503072
Identification of the Real Hub Gene and Construction of a Novel Prognostic Signature for Pancreatic Adenocarcinoma Based on the Weighted Gene Co-expression Network Analysis and Least Absolute Shrinkage and Selection Operator Algorithms. PMID:34490033
Clinical and therapeutic relevance of cancer-associated fibroblasts. PMID:34489603
GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma. PMID:34489334
Prognostic role of EGR1 in breast cancer: a systematic review. PMID:34488929
A pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers. PMID:34486492
SAMHD1 in cancer: curse or cure? PMID:34480199
Prospects and challenges of cancer systems medicine: from genes to disease networks. PMID:34471925
Prognostic and Immunological Role of THBS2 in Colorectal cancer. PMID:34471634
Proteome heterogeneity and malignancy detection in pancreatic cyst fluids. PMID:34459141
Multi-Tissue Transcriptomic-Informed In Silico Investigation of Drugs for the Treatment of Dengue Fever Disease. PMID:34452405
HOXB8 Counteracts MAPK/ERK Oncogenic Signaling in a Chicken Embryo Model of Neoplasia. PMID:34445617
Antagonistic Interaction between Histone Deacetylase Inhibitor: Cambinol and Cisplatin-An Isobolographic Analysis in Breast Cancer In Vitro Models. PMID:34445277
A Transcriptomic Analysis of Head and Neck Squamous Cell Carcinomas for Prognostic Indications. PMID:34442426
GDF-15 Predicts In-Hospital Mortality of Critically Ill Patients with Acute Kidney Injury Requiring Continuous Renal Replacement Therapy: A Multicenter Prospective Study. PMID:34441955
Survival-Based Biomarker Module Identification Associated with Oral Squamous Cell Carcinoma (OSCC). PMID:34439992
Thermodynamic Genome-Scale Metabolic Modeling of Metallodrug Resistance in Colorectal Cancer. PMID:34439283
Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential. PMID:34438259
Bothrops Jararaca Snake Venom Modulates Key Cancer-Related Proteins in Breast Tumor Cell Lines. PMID:34437390
Lipid Transporters Beam Signals from Cell Membranes. PMID:34436325
Construction and Verification of a Hypoxia-Related 4-lncRNA Model for Prediction of Breast Cancer. PMID:34429643
DeepHistoClass: A Novel Strategy for Confident Classification of Immunohistochemistry Images Using Deep Learning. PMID:34425263
DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma. PMID:34414037
Screening of DNA Damage Repair Genes Involved in the Prognosis of Triple-Negative Breast Cancer Patients Based on Bioinformatics. PMID:34408776
Bioinformatics analysis of the transcriptional expression of minichromosome maintenance proteins as potential indicators of survival in patients with cervical cancer. PMID:34404366
FK506 binding protein 10: a key actor of collagen crosslinking in clear cell renal cell carcinoma. PMID:34388114
Integrated Bioinformatics Analysis of DNA Methylation Biomarkers in Thyroid Cancer Based on TCGA Database. PMID:34387764
Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma. PMID:34385447
Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation. PMID:34381018
The Partial Role of KLF4 and KLF5 in Gastrointestinal Tumors. PMID:34367275
Netrin-1 in Glioblastoma Neovascularization: The New Partner in Crime? PMID:34361013
Immunohistochemical Evaluation of FGD3 Expression: A New Strong Prognostic Factor in Invasive Breast Cancer. PMID:34359725
Differences in Extracellular Vesicle Protein Cargo Are Dependent on Head and Neck Squamous Cell Carcinoma Cell of Origin and Human Papillomavirus Status. PMID:34359613
The Role of DND1 in Cancers. PMID:34359581
Loss of Lymphotoxin Alpha-Expressing Memory B Cells Correlates with Metastasis of Human Primary Melanoma. PMID:34359321
Exploring the Role of Endoplasmic Reticulum Stress in Hepatocellular Carcinoma through mining of the Human Protein Atlas. PMID:34356495
Pipelines and Systems for Threshold-Avoiding Quantification of LC-MS/MS Data. PMID:34355890
Alterations in protein expression and site-specific N-glycosylation of prostate cancer tissues. PMID:34354152
Proteome-Wide Profiling of Readers for DNA Modification. PMID:34351703
Characterization of Five Transmembrane Proteins: With Focus on the Tweety, Sideroflexin, and YIP1 Domain Families. PMID:34350187
DNA and RNA Sequencing Recapitulated Aberrant Tumor Metabolism in Liver Cancer Cell Lines. PMID:34350138
Cancer cell line microarray as a novel screening method for identification of radioresistance biomarkers in head and neck squamous cell carcinoma. PMID:34320941
Amine oxidase, copper containing 3 exerts anti‑mesenchymal transformation and enhances CD4+ T‑cell recruitment to prolong survival in lung cancer. PMID:34318901
A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells. PMID:34316707
lncRNA-PACER upregulates COX-2 and PGE2 through the NF-κB pathway to promote the proliferation and invasion of colorectal-cancer cells. PMID:34316376
SRSF10: an atypical splicing regulator with critical roles in stress response, organ development, and viral replication. PMID:34315816
Study on HOXBs of Clear Cell Renal Cell Carcinoma and Detection of New Molecular Target. PMID:34306077
KCNN4 is a potential prognostic marker and critical factor affecting the immune status of the tumor microenvironment in kidney renal clear cell carcinoma. PMID:34295732
Clinical Value and Underlying Mechanisms of Upregulated LINC00485 in Hepatocellular Carcinoma. PMID:34290977
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth. PMID:34290111
Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinoma. PMID:34290079
PGK1 Is a Key Target for Anti-Glycolytic Therapy of Ovarian Cancer: Based on the Comprehensive Analysis of Glycolysis-Related Genes. PMID:34277429
Type 1 conventional dendritic cells and interferons are required for spontaneous CD4+ and CD8+ T-cell protective responses to breast cancer. PMID:34277006
TCF11 Has a Potent Tumor-Repressing Effect Than Its Prototypic Nrf1α by Definition of Both Similar Yet Different Regulatory Profiles, With a Striking Disparity From Nrf2. PMID:34268128
Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning. PMID:34258555
Bioinformatics Analysis of Candidate Genes and Pathways Related to Hepatocellular Carcinoma in China: A Study Based on Public Databases. PMID:34257537
Identification of an Metabolic Related Risk Signature Predicts Prognosis in Cervical Cancer and Correlates With Immune Infiltration. PMID:34249930
Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer. PMID:34249755
Identification of an EMT-Related Gene Signature for Predicting Overall Survival in Gastric Cancer. PMID:34249086
Glycolysis-Related Gene Expression Profiling Screen for Prognostic Risk Signature of Pancreatic Ductal Adenocarcinoma. PMID:34249078
Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy. PMID:34246985
Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip. PMID:34239116
A miR-212-3p/SLC6A1 Regulatory Sub-Network for the Prognosis of Hepatocellular Carcinoma. PMID:34234551
Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype. PMID:34233711
Prognostic signature composed of transcription factors accurately predicts the prognosis of gastric cancer patients. PMID:34233659
Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations. PMID:34232958
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma. PMID:34231338
GNRH1 and LTB4R might be novel immune-related prognostic biomarkers in clear cell renal cell carcinoma (ccRCC). PMID:34229684
Prognostic and immunological value of ATP6AP1 in breast cancer: implications for SARS-CoV-2. PMID:34228637
High prevalence of APOA1/C3/A4/A5 alterations in luminal breast cancers among young women in East Asia. PMID:34226567
Genome-wide association study of stimulant dependence. PMID:34226506
Desmoglein 2 (DSG2) Is A Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia. PMID:34224109
Exploring the Metabolic Heterogeneity of Cancers: A Benchmark Study of Context-Specific Models. PMID:34205912
Structure vs. Function of TRIB1-Myeloid Neoplasms and Beyond. PMID:34205360
Patterns of Gene Expression in Cutaneous T-Cell Lymphoma: Systematic Review of Transcriptomic Studies in Mycosis Fungoides. PMID:34204115
PDLIM2 Suppression Inhibit Proliferation and Metastasis in Kidney Cancer. PMID:34203785
On the Need to Tell Apart Fraternal Twins eEF1A1 and eEF1A2, and Their Respective Outfits. PMID:34203525
Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction. PMID:34202278
ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated Heparin. PMID:34200372
In-depth proteomics analysis of sentinel lymph nodes from individuals with endometrial cancer. PMID:34195683
Genomic and Transcriptome Analysis to Identify the Role of the mTOR Pathway in Kidney Renal Clear Cell Carcinoma and Its Potential Therapeutic Significance. PMID:34194607
Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study. PMID:34180758
Infiltrating T-cell abundance combined with EMT-related gene expression as a prognostic factor of colon cancer. PMID:34180352
Quantum processor-inspired machine learning in the biomedical sciences. PMID:34179840
The Identification of Stemness-Related Genes in the Risk of Head and Neck Squamous Cell Carcinoma. PMID:34178686
Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value. PMID:34178669
TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer. PMID:34178620
Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression. PMID:34174926
T-Cell Receptor Mimic Antibodies for Cancer Immunotherapy. PMID:34172530
Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor. PMID:34159897
EGFR-targeted intraoperative fluorescence imaging detects high-grade glioma with panitumumab-IRDye800 in a phase 1 clinical trial. PMID:34158840
Identification of significant genes and therapeutic agents for breast cancer by integrated genomics. PMID:34151730
A Poliovirus Receptor (CD155)-Related Risk Signature Predicts the Prognosis of Bladder Cancer. PMID:34150627
Upregulation of LIMK1 Is Correlated With Poor Prognosis and Immune Infiltrates in Lung Adenocarcinoma. PMID:34149814
CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients. PMID:34149710
Analyzing cancer gene expression data through the lens of normal tissue-specificity. PMID:34143767
Construction of a Myc-associated ceRNA network reveals a prognostic signature in hepatocellular carcinoma. PMID:34141458
DGLinker: flexible knowledge-graph prediction of disease-gene associations. PMID:34125897
Editorial: Application of Systems Biology in Molecular Characterization and Diagnosis of Cancer. PMID:34124153
The increased expression and aberrant methylation of SHC1 in non-small cell lung cancer: Integrative analysis of clinical and bioinformatics databases. PMID:34117717
Human Gastric Cancer Stem Cell (GCSC) Markers Are Prognostic Factors Correlated With Immune Infiltration of Gastric Cancer. PMID:34113647
ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes. PMID:34107900
RNA pull-down confocal nanoscanning (RP-CONA) detects quercetin as pri-miR-7/HuR interaction inhibitor that decreases α-synuclein levels. PMID:34107032
A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy. PMID:34106735
Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancer. PMID:34104539
An integrative microenvironment approach for laryngeal carcinoma: the role of immune/methylation/autophagy signatures on disease clinical prognosis and single-cell genotypes. PMID:34093817
Identification of crucial genes and pathways associated with prostate cancer in multiple databases. PMID:34082608
Tracking the Antibody Immunome in Sporadic Colorectal Cancer by Using Antigen Self-Assembled Protein Arrays. PMID:34072782
GWAS Links New Variant in Long Non-Coding RNA LINC02006 with Colorectal Cancer Susceptibility. PMID:34070617
Validation of Selected Head and Neck Cancer Prognostic Markers from the Pathology Atlas in an Oral Tongue Cancer Cohort. PMID:34069237
GeromiRs Are Downregulated in the Tumor Microenvironment during Colon Cancer Colonization of the Liver in a Murine Metastasis Model. PMID:34062897
Genome-Wide Analysis of Sex Disparities in the Genetic Architecture of Lung and Colorectal Cancers. PMID:34062886
Prostate cancer risk variants of the HOXB genetic locus. PMID:34059701
Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2'-O-methyl gapmer oligonucleotides. PMID:34057477
Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors. PMID:34051140
A Novel Ferroptosis Related Gene Signature for Prognosis Prediction in Patients With Colon Cancer. PMID:34046350
CRED9: A differentially expressed elncRNA regulates expression of transcription factor CEBPA. PMID:34039742
CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells. PMID:34036248
The prognostic value of galactosylceramide-sulfotransferase (Gal3ST1) in human renal cell carcinoma. PMID:34035403
Up-regulated RFC2 predicts unfavorable progression in hepatocellular carcinoma. PMID:34022962
SFRP2 induces a mesenchymal subtype transition by suppression of SOX2 in glioblastoma. PMID:34021259
Comprehensive analysis of the prognostic value and immune function of the IDO1 gene in gynecological cancers. PMID:34017374
Comprehensive analysis of the prognostic value of the chemokine-like factor-like MARVEL transmembrane domain-containing family in gastric cancer. PMID:34012634
ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis. PMID:34007003
PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR. PMID:34002693
A systematic dissection of the epigenomic heterogeneity of lung adenocarcinoma reveals two different subclasses with distinct prognosis and core regulatory networks. PMID:34001209
Polycomb Factor PHF19 Controls Cell Growth and Differentiation Toward Erythroid Pathway in Chronic Myeloid Leukemia Cells. PMID:33996816
Five-gene signature associating with Gleason score serve as novel biomarkers for identifying early recurring events and contributing to early diagnosis for Prostate Adenocarcinoma. PMID:33995639
MTFR2, A Potential Biomarker for Prognosis and Immune Infiltrates, Promotes Progression of Gastric Cancer Based on Bioinformatics Analysis and Experiments. PMID:33995638
HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1. PMID:33990627
Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer. PMID:33981003
Functional inhibition of cancer stemness-related protein DPP4 rescues tyrosine kinase inhibitor resistance in renal cell carcinoma. PMID:33972682
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. PMID:33972514
Validation of the functions and prognostic values of synapse-associated proteins in lower-grade glioma. PMID:33969375
Analysis of the EGFR Amplification and CDKN2A Deletion Regulated Transcriptomic Signatures Reveals the Prognostic Significance of SPATS2L in Patients With Glioma. PMID:33959491
Human cell receptors: potential drug targets to combat COVID-19. PMID:33950300
Down-regulation of microRNA-125b-2-3p is a risk factor for a poor prognosis in hepatocellular carcinoma. PMID:33949293
Immuno-PET Molecular Imaging of RANKL in Cancer. PMID:33946410
Prognostic Significance of Autophagy-Relevant Gene Markers in Colorectal Cancer. PMID:33937013
Identification of SHMT2 as a Potential Prognostic Biomarker and Correlating with Immune Infiltrates in Lung Adenocarcinoma. PMID:33928169
Identification of a ferroptosis-related gene signature predictive model in colon cancer. PMID:33926457
IFN-λ Modulates the Migratory Capacity of Canine Mammary Tumor Cells via Regulation of the Expression of Matrix Metalloproteinases and Their Inhibitors. PMID:33922837
STAT6 Is Critical for the Induction of Regulatory T Cells In Vivo Controlling the Initial Steps of Colitis-Associated Cancer. PMID:33919941
Functional Roles of SPINK1 in Cancers. PMID:33916984
Malignant Pleural Mesothelioma Interactome with 364 Novel Protein-Protein Interactions. PMID:33916178
Functional Fine-Tuning of Metabolic Pathways by the Endocannabinoid System-Implications for Health and Disease. PMID:33915889
A molecular single-cell lung atlas of lethal COVID-19. PMID:33915568
Histone degradation by the proteasome regulates chromatin and cellular plasticity. PMID:33914417
CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Acting in cis. PMID:33910952
Local and CNS-Wide Astrocyte Intracellular Calcium Signaling Attenuation In Vivo with CalExflox Mice. PMID:33903221
Effect of HPV 16 E6 Oncoprotein Variants on the Alterations of the Proteome of C33A Cells. PMID:33893080
Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers. PMID:33869024
Interaction Networks Converging on Immunosuppressive Roles of Granzyme B: Special Niches Within the Tumor Microenvironment. PMID:33868318
Integrated Profiling Identifies CCNA2 as a Potential Biomarker of Immunotherapy in Breast Cancer. PMID:33859479
Systematic analysis of the function and prognostic value of RNA binding proteins in Colon Adenocarcinoma. PMID:33854615
CD8+ T Lymphocyte Coexpression Genes Correlate with Immune Microenvironment and Overall Survival in Breast Cancer. PMID:33854546
TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes. PMID:33849445
iNetModels 2.0: an interactive visualization and database of multi-omics data. PMID:33849075
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones. PMID:33846299
Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations. PMID:33823788
An R package for divergence analysis of omics data. PMID:33819273
Search, access, and explore life science nanopublications on the Web. PMID:33816986
Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer. PMID:33812801
Prognostic and Functional Significant of Heat Shock Proteins (HSPs) in Breast Cancer Unveiled by Multi-Omics Approaches. PMID:33810095
Identifying Molecular Signatures of Distinct Modes of Collective Migration in Response to the Microenvironment Using Three-Dimensional Breast Cancer Models. PMID:33804802
Lipid Rafts Interaction of the ARID3A Transcription Factor with EZRIN and G-Actin Regulates B-Cell Receptor Signaling. PMID:33804610
Grainyhead-Like 3 Influences Migration and Invasion of Urothelial Carcinoma Cells. PMID:33803949
The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases. PMID:33800554
Leptin and Cancer: Updated Functional Roles in Carcinogenesis, Therapeutic Niches, and Developments. PMID:33799880
Tumor Immunometabolism Characterization in Ovarian Cancer With Prognostic and Therapeutic Implications. PMID:33796460
A Critical Role of Peptidylprolyl Isomerase A Pseudogene 22/microRNA-197-3p/Peptidylprolyl Isomerase A Axis in Hepatocellular Carcinoma. PMID:33790943
Differential MUC22 expression by epigenetic alterations in human lung squamous cell carcinoma and adenocarcinoma. PMID:33786615
Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19. PMID:33767597
Differential expression of protein disulfide-isomerase A3 isoforms, PDIA3 and PDIA3N, in human prostate cancer cell lines representing different stages of prostate cancer. PMID:33761087
The exon junction complex core factor eIF4A3 is a key regulator of HPV16 gene expression. PMID:33760064
Essential requirement for JPT2 in NAADP-evoked Ca2+ signaling. PMID:33758061
Tumor-penetrating therapy for β5 integrin-rich pancreas cancer. PMID:33750829
Metabolic alterations and vulnerabilities in hepatocellular carcinoma. PMID:33747521
Nidogen-1 expression is associated with overall survival and temozolomide sensitivity in low-grade glioma patients. PMID:33735110
Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL. PMID:33727310
The role of WDR76 protein in human diseases. PMID:33714259
Integrated analysis of RNA-binding proteins in thyroid cancer. PMID:33711033
Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing. PMID:33708225
Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis. PMID:33707612
Development of a Gene-Based Prediction Model for Recurrence of Colorectal Cancer Using an Ensemble Learning Algorithm. PMID:33692961
Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers. PMID:33692504
A multi-scale integrated analysis identifies KRT8 as a pan-cancer early biomarker. PMID:33691026
SSRP1 Is a Prognostic Biomarker Correlated with CD8+ T Cell Infiltration in Hepatocellular Carcinoma (HCC). PMID:33688504
Expression and prognostic value of transcription-associated cyclin-dependent kinases in human breast cancer. PMID:33686962
Potential role of glucosamine-phosphate N-acetyltransferase 1 in the development of lung adenocarcinoma. PMID:33686019
RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors. PMID:33684443
CD96 Correlates With Immune Infiltration and Impacts Patient Prognosis: A Pan-Cancer Analysis. PMID:33680972
Expression of ADAM Proteases in Bladder Cancer Patients with BCG Failure: A Pilot Study. PMID:33672843
The Multiple Cellular Roles of SMUG1 in Genome Maintenance and Cancer. PMID:33671338
Key Enzymes in Pyrimidine Synthesis, CAD and CPS1, Predict Prognosis in Hepatocellular Carcinoma. PMID:33670206
Abnormal dopamine receptor signaling allows selective therapeutic targeting of neoplastic progenitors in AML patients. PMID:33665638
Zinc Finger Protein CTCF Regulates Extracellular Matrix (ECM)-Related Gene Expression Associated With the Wnt Signaling Pathway in Gastric Cancer. PMID:33665169
Interleukin-1 receptor-associated kinase 4 as a potential biomarker: Overexpression predicts poor prognosis in patients with glioma. PMID:33664818
Interleukin-18 promotes the antitumor ability of natural killer cells in colorectal cancer via the miR-574-3p/TGF-β1 axis. PMID:33660570
Transcriptional Biomarkers in Oral Cancer: An Integrative Analysis and the Cancer Genome Atlas Validation. PMID:33639650
Identification of a Gene Signature for Renal Cell Carcinoma-Associated Fibroblasts Mediating Cancer Progression and Affecting Prognosis. PMID:33634098
Knockdown of RIPK2 Inhibits Proliferation and Migration, and Induces Apoptosis via the NF-κB Signaling Pathway in Gastric Cancer. PMID:33633788
Spatiotemporal dissection of the cell cycle with single-cell proteogenomics. PMID:33627808
Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2. PMID:33609069
Identification of Key Gene Signatures Associated With Bone Metastasis in Castration-Resistant Prostate Cancer Using Co-Expression Analysis. PMID:33604283
Effect of Glucose Variability on Pancreatic Cancer Through Regulation of COL6A1. PMID:33603474
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity. PMID:33594203
Evaluation of prognostic biomarkers in a population-validated Finnish HNSCC patient cohort. PMID:33582846
Transcriptome analysis of the procession from chronic pancreatitis to pancreatic cancer and metastatic pancreatic cancer. PMID:33564087
p53 dynamics vary between tissues and are linked with radiation sensitivity. PMID:33563973
A PSMA-targeted theranostic approach is unlikely to be efficient in serous ovarian cancers. PMID:33559764
Up-regulation of L Antigen Family Member 3 Associates With Aggressive Progression of Breast Cancer. PMID:33552947
Identification of Novel Biomarkers Associated With the Prognosis and Potential Pathogenesis of Breast Cancer via Integrated Bioinformatics Analysis. PMID:33550915
SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation. PMID:33542242
Distinct roles for the RNA-binding protein Staufen1 in prostate cancer. PMID:33541283
PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis. PMID:33531346
Alternative polyadenylation: methods, mechanism, function, and role in cancer. PMID:33526057
DeCompress: tissue compartment deconvolution of targeted mRNA expression panels using compressed sensing. PMID:33524140
Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance. PMID:33513345
Increased SPHK1 and HAS2 Expressions Correlate to Poor Prognosis in Pancreatic Cancer. PMID:33506044
HPAStainR: a Bioconductor and Shiny app to query protein expression patterns in the Human Protein Atlas. PMID:33500778
Disturbed intramitochondrial phosphatidic acid transport impairs cellular stress signaling. PMID:33497623
Exogenous exposure to dihydroxyacetone mimics high fructose induced oxidative stress and mitochondrial dysfunction. PMID:33496975
Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis. PMID:33495413
Transcriptomic characterization reveals prognostic molecular signatures of sorafenib resistance in hepatocellular carcinoma. PMID:33495404
Expression and prognostic analyses of SCAMPs in pancreatic adenocarcinoma. PMID:33493138
The Prognostic Value of DNA Methylation, Post-Translational Modifications and Correlated with Immune Infiltrates in Gynecologic Cancers. PMID:33488112
Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling. PMID:33480129
Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers. PMID:33478099
Terminal Deoxynucleotidyl Transferase Commonly Expresses in Germ Cell Tumors: Evaluation on a Large Series from Multiple Centers. PMID:33469349
A Pound of Flesh: What Cachexia Is and What It Is Not. PMID:33445790
Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro Models. PMID:33445709
Combined RNA/tissue profiling identifies novel Cancer/testis genes. PMID:33426787
Identification of a Transcriptional Prognostic Signature From Five Metabolic Pathways in Oral Squamous Cell Carcinoma. PMID:33425725
Upregulation of RAC3 in bladder cancer predicts adverse clinical outcome and increased tumor immune response. PMID:33425095
ACOX2 is a prognostic marker and impedes the progression of hepatocellular carcinoma via PPARα pathway. PMID:33414412
Integrated bioinformatic analysis of RNA binding proteins in hepatocellular carcinoma. PMID:33411682
Construction of a nine DNA repair-related gene prognostic classifier to predict prognosis in patients with endometrial carcinoma. PMID:33407221
Identifying Personalized Metabolic Signatures in Breast Cancer. PMID:33396819
Macrophage imaging and subset analysis using single-cell RNA sequencing. PMID:33391974
Cytosolic Ca2+ transients during pulsed focused ultrasound generate reactive oxygen species and cause DNA damage in tumor cells. PMID:33391495
Loss of LIMCH1 predicts poor prognosis in patients with surgically resected Lung Adenocarcinoma: A study based on Immunohistochemical Analysis and Bioinformatics. PMID:33391414
Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma. PMID:33390805
piNET-An Automated Proliferation Index Calculator Framework for Ki67 Breast Cancer Images. PMID:33375043
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones. PMID:33374813
Omics Integration Analysis Unravel the Landscape of Driving Mechanisms of Colorectal Cancer. PMID:33369450
Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma. PMID:33365083
Analysis of Pan-omics Data in Human Interactome Network (APODHIN). PMID:33363571
Upregulation of polycistronic microRNA-143 and microRNA-145 in colonocytes suppresses colitis and inflammation-associated colon cancer. PMID:33356812
Germline variation of Ribonuclease H2 genes in ovarian cancer patients. PMID:33353557
Titration of SF3B1 Activity Reveals Distinct Effects on the Transcriptome and Cell Physiology. PMID:33348896
Prognostic relevance of programmed cell death 1 ligand 2 (PDCD1LG2/PD-L2) in patients with advanced stage colon carcinoma treated with chemotherapy. PMID:33339860
Decreasing the Susceptibility of Malignant Cells to Infection Does Not Impact the Overall Efficacy of Myxoma Virus-Based Oncolytic Virotherapy. PMID:33335977
Resorufin Enters the Photodynamic Therapy Arena: A Monoamine Oxidase Activatable Agent for Selective Cytotoxicity. PMID:33335672
IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates. PMID:33324675
Keratin 17 Suppresses Cell Proliferation and Epithelial-Mesenchymal Transition in Pancreatic Cancer. PMID:33324659
"Inflammatory Leiomyosarcoma" and "Histiocyte-rich Rhabdomyoblastic Tumor": a clinicopathological, immunohistochemical and genetic study of 13 cases, with a proposal for reclassification as "Inflammatory Rhabdomyoblastic Tumor". PMID:33318583
Identification and prognostic value of DLGAP5 in endometrial cancer. PMID:33312770
PTRH2: an adhesion regulated molecular switch at the nexus of life, death, and differentiation. PMID:33298880
Prognostic and Predictive Value of a 15 Transcription Factors (TFs) Panel for Hepatocellular Carcinoma. PMID:33293862
MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role. PMID:33293474
Prospects for Using Expression Patterns of Paramyxovirus Receptors as Biomarkers for Oncolytic Virotherapy. PMID:33291506
Abnormal expression of HNRNPA3 in multistep hepatocarcinogenesis. PMID:33281957
CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells. PMID:33251215
A Novel RNA Binding Protein-Related Prognostic Signature for Hepatocellular Carcinoma. PMID:33251144
PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2). PMID:33245768
Multiple functions of TBCK protein in neurodevelopment disorders and tumors. PMID:33240423
Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts. PMID:33237278
BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage. PMID:33236795
Multiorgan Signaling Mobilizes Tumor-Associated Erythroid Cells Expressing Immune Checkpoint Molecules. PMID:33234577
Group 2 Innate Lymphoid Cells: A Double-Edged Sword in Cancer? PMID:33233582
Expression of Pro-Angiogenic Markers Is Enhanced by Blue Light in Human RPE Cells. PMID:33233546
Possible role of glial cell line-derived neurotrophic factor for predicting cognitive impairment in Parkinson's disease: a case-control study. PMID:33229724
Downstream Neighbor of SON (DONSON) Expression Is Enhanced in Phenotypically Aggressive Prostate Cancers. PMID:33228112
FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis. PMID:33219235
Epigenetic Alterations in Keratinocyte Carcinoma. PMID:33212152
Upregulation of ERCC6L is associated with tumor progression and unfavorable prognosis in hepatocellular carcinoma. PMID:33209494
Comprehensive analysis of the prognosis for chromobox family in gastric cancer. PMID:33209489
SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion. PMID:33207694
A Distance-Based Framework for the Characterization of Metabolic Heterogeneity in Large Sets of Genome-Scale Metabolic Models. PMID:33205127
The Expression Profiles of ADME Genes in Human Cancers and Their Associations with Clinical Outcomes. PMID:33202946
Evaluating the biological functions of the prognostic genes identified by the Pathology Atlas in bladder cancer. PMID:33200223
Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment. PMID:33194695
Immune Microenvironment Related Competitive Endogenous RNA Network as Powerful Predictors for Melanoma Prognosis Based on WGCNA Analysis. PMID:33194692
Prognostic Implications of Novel Ten-Gene Signature in Uveal Melanoma. PMID:33194647
Effects of RNA Binding Proteins on the Prognosis and Malignant Progression in Prostate Cancer. PMID:33193734
Integration of Online Omics-Data Resources for Cancer Research. PMID:33193699
TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019. PMID:33193689
Theoretical and in silico Analyses Reveal MYC as a Dynamic Network Biomarker in Colon and Rectal Cancer. PMID:33193630
Expression Profile of GINS Complex Predicts the Prognosis of Pancreatic Cancer Patients. PMID:33192076
A Targeted Bioinformatics Assessment of Adrenocortical Carcinoma Reveals Prognostic Implications of GABA System Gene Expression. PMID:33187258
Effect of Varying Expression of EpCAM on the Efficiency of CTCs Detection by SERS-Based Immunomagnetic Optofluidic Device. PMID:33182636
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4. PMID:33182504
Transcriptomics and Prognosis Analysis to Identify Critical Biomarkers in Invasive Breast Carcinoma. PMID:33176622
The mechanobiome: a goldmine for cancer therapeutics. PMID:33175572
The Interplay between Cancer Biology and the Endocannabinoid System-Significance for Cancer Risk, Prognosis and Response to Treatment. PMID:33167409
Interleukin 25 (IL-25) expression in cholangiocarcinoma. PMID:33163180
The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma. PMID:33154775
Evolution from adherent to suspension: systems biology of HEK293 cell line development. PMID:33149219
The Human Protein Atlas-Spatial localization of the human proteome in health and disease. PMID:33146890
Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment. PMID:33146700
BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling. PMID:33142801
Genomic Analysis of Vascular Invasion in HCC Reveals Molecular Drivers and Predictive Biomarkers. PMID:33140851
Analysis of Melanoma Secretome for Factors That Directly Disrupt the Barrier Integrity of Brain Endothelial Cells. PMID:33139674
Revealing Prognosis-Related Pathways at the Individual Level by a Comprehensive Analysis of Different Cancer Transcription Data. PMID:33138076
Epigenome-Wide Association Study Using Prediagnostic Bloods Identifies New Genomic Regions Associated With Pancreatic Cancer Risk. PMID:33134824
Learning Cell-Type-Specific Gene Regulation Mechanisms by Multi-Attention Based Deep Learning With Regulatory Latent Space. PMID:33133123
Targeting CREB in Cancer Therapy: A Key Candidate or One of Many? An Update. PMID:33126560
SMARCD3 is a potential prognostic marker and therapeutic target in CAFs. PMID:33125346
Construction of novel mRNA-miRNA-lncRNA regulatory networks associated with prognosis of ovarian cancer. PMID:33123295
Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma. PMID:33114768
CCL18 in the Progression of Cancer. PMID:33114763
Functional and genomic characterization of patient-derived xenograft model to study the adaptation to mTORC1 inhibitor in clear cell renal cell carcinoma. PMID:33107222
Expression and Prognostic Analyses of ITGA3, ITGA5, and ITGA6 in Head and Neck Squamous Cell Carcinoma. PMID:33099569
Identification of PKP 2/3 as potential biomarkers of ovarian cancer based on bioinformatics and experiments. PMID:33088217
Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression. PMID:33087347
Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable. PMID:33086039
An immunochemistry-based screen for chemical inhibitors of DNA-protein interactions and its application to human CGGBP1. PMID:33081720
Cancer prognosis prediction using somatic point mutation and copy number variation data: a comparison of gene-level and pathway-based models. PMID:33081688
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands. PMID:33076281
Bromodomain-containing protein 4 regulates interleukin-34 expression in mouse ovarian cancer cells. PMID:33072227
Assessing the Role of Long Noncoding RNA in Nucleus Accumbens in Subjects With Alcohol Dependence. PMID:33067813
A high-stringency blueprint of the human proteome. PMID:33067450
High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro. PMID:33051432
Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis. PMID:33050659
Deep transfer learning for reducing health care disparities arising from biomedical data inequality. PMID:33046699
TRIP13 predicts poor prognosis in clear cell renal cell carcinoma. PMID:33042625
Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer. PMID:33030783
A New Prognostic Risk Model Based on PPAR Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma. PMID:33029112
A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer. PMID:33024794
TYROBP is a potential prognostic biomarker of clear cell renal cell carcinoma. PMID:33015999
Regulation and pharmacological targeting of RAD51 in cancer. PMID:33015624
G-Quadruplex Helicase DHX36/G4R1 Engages Nuclear Lamina Proteins in Quiescent Breast Cancer Cells. PMID:33015511
Immune Checkpoint Blockade Improves Chemotherapy in the PyMT Mammary Carcinoma Mouse Model. PMID:33014872
The Molecular Basis of Malignant Pleural Mesothelioma. PMID:33012428
Cancer diagnostics based on plasma protein biomarkers: hard times but great expectations. PMID:33012111
Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment. PMID:33003469
Embedding covariate adjustments in tree-based automated machine learning for biomedical big data analyses. PMID:32998684
Schlafen 12 Is Prognostically Favorable and Reduces C-Myc and Proliferation in Lung Adenocarcinoma but Not in Lung Squamous Cell Carcinoma. PMID:32987632
PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer. PMID:32985124
KLK3 and TMPRSS2 for molecular lymph-node staging in prostate cancer patients undergoing radical prostatectomy. PMID:32978525
Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery. PMID:32977469
TREND-DB-a transcriptome-wide atlas of the dynamic landscape of alternative polyadenylation. PMID:32976578
Another Consequence of the Warburg Effect? Metabolic Regulation of Na+/H+ Exchangers May Link Aerobic Glycolysis to Cell Growth. PMID:32974190
Identification of key genes and functions of circulating tumor cells in multiple cancers through bioinformatic analysis. PMID:32972417
Bioinformatics analysis and experimental validation of TTK as a biomarker for prognosis in non-small cell lung cancer. PMID:32969465
SPAG5 is associated with unfavorable prognosis in patients with lung adenocarcinoma and promotes proliferation, motility and autophagy in A549 cells. PMID:32968434
Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning. PMID:32967266
Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma. PMID:32963945
Natural Compounds Modulate Drug Transporter Mediated Oral Cancer Treatment. PMID:32957726
Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma. PMID:32951278
Identification of Key Prognostic Biomarker and Its Correlation with Immune Infiltrates in Pancreatic Ductal Adenocarcinoma. PMID:32934754
An era of single-cell genomics consortia. PMID:32929222
Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism. PMID:32927708
Pinpointing Cell Identity in Time and Space. PMID:32923457
Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages. PMID:32923173
Development and validation of a DNA repair gene signature for prognosis prediction in Colon Cancer. PMID:32922534
Identification of Prostate Cancer-Related Circular RNA Through Bioinformatics Analysis. PMID:32922436
TRIM33 Overexpression Inhibits the Progression of Clear Cell Renal Cell Carcinoma In Vivo and In Vitro. PMID:32908919
Integrated PPI- and WGCNA-Retrieval of Hub Gene Signatures Shared Between Barrett's Esophagus and Esophageal Adenocarcinoma. PMID:32903837
Investigating the Role of Telomere and Telomerase Associated Genes and Proteins in Endometrial Cancer. PMID:32899298
GAB2 and GAB3 are expressed in a tumor stage-, grade- and histotype-dependent manner and are associated with shorter progression-free survival in ovarian cancer. PMID:32888136
SHIP2 inhibition alters redox-induced PI3K/AKT and MAP kinase pathways via PTEN over-activation in cervical cancer cells. PMID:32881386
Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer. PMID:32878499
Identification of potential biomarkers and candidate small molecule drugs in glioblastoma. PMID:32874133
Low Baseline Pulmonary Levels of Cytotoxic Lymphocytes as a Predisposing Risk Factor for Severe COVID-19. PMID:32873611
Plasma protein-based signature predicts distant metastasis and induction chemotherapy benefit in Nasopharyngeal Carcinoma. PMID:32863958
Glycogene Expression Profiling of Hepatic Cells by RNA-Seq Analysis for Glyco-Biomarker Identification. PMID:32850363
SBML Level 3: an extensible format for the exchange and reuse of biological models. PMID:32845085
Role of CITED2 in stem cells and cancer. PMID:32831926
NELL1 is a target antigen in malignancy-associated membranous nephropathy. PMID:32828756
The intermembrane space protein Mix23 is a novel stress-induced mitochondrial import factor. PMID:32826315
The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes. PMID:32811853
Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis? PMID:32811540
Downstream neighbor of SON (DONSON) is associated with unfavorable survival across diverse cancers with oncogenic properties in clear cell renal cell carcinoma. PMID:32805676
Decreased Expression of ZNF554 in Gliomas is Associated with the Activation of Tumor Pathways and Shorter Patient Survival. PMID:32796700
Reduced expression of odd-skipped related transcription factor 1 promotes proliferation and invasion of breast cancer cells and indicates poor patient prognosis. PMID:32782611
Expression and clinical significance of methyl-CpG binding domain protein 2 in high-grade serous ovarian cancer. PMID:32782591
Role of CYP4F2 as a novel biomarker regulating malignant phenotypes of liver cancer cells via the Nrf2 signaling axis. PMID:32774486
Identification of Immune-Related Genes Contributing to the Development of Glioblastoma Using Weighted Gene Co-expression Network Analysis. PMID:32765489
Oncogenic Features in Histologically Normal Mucosa: Novel Insights Into Field Effect From a Mega-Analysis of Colorectal Transcriptomes. PMID:32764205
Current Knowledge on the Function of α-Methyl Acyl-CoA Racemase in Human Diseases. PMID:32760737
IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion. PMID:32753652
Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder. PMID:32744794
High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes. PMID:32733792
Mining the prognostic significance of the GINS2 gene in human breast cancer using bioinformatics analysis. PMID:32724372
Construction of a novel prognostic-predicting model correlated to ovarian cancer. PMID:32716025
Integrative Network Fusion: A Multi-Omics Approach in Molecular Profiling. PMID:32714870
Guarding the Genome: CENP-A-Chromatin in Health and Cancer. PMID:32708729
Relationship between a 7-mRNA signature of the pancreatic adenocarcinoma microenvironment and patient prognosis (a STROBE-compliant article). PMID:32702921
RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha. PMID:32697984
PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells. PMID:32692719
A new survival model based on ferroptosis-related genes for prognostic prediction in clear cell renal cell carcinoma. PMID:32688345
An information-theoretic approach for measuring the distance of organ tissue samples using their transcriptomic signatures. PMID:32683449
Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers. PMID:32679804
The Activity of KIF14, Mieap, and EZR in a New Type of the Invasive Component, Torpedo-Like Structures, Predetermines the Metastatic Potential of Breast Cancer. PMID:32679794
Negative feedback regulation by HuR controls TRIM21 expression and function in response to UV radiation. PMID:32678213
WFDC2 suppresses prostate cancer metastasis by modulating EGFR signaling inactivation. PMID:32678075
Identification of cell division cycle 20 as a candidate biomarker and potential therapeutic target in bladder cancer using bioinformatics analysis. PMID:32677673
Integrated analysis of optical mapping and whole-genome sequencing reveals intratumoral genetic heterogeneity in metastatic lung squamous cell carcinoma. PMID:32676329
A COMMON PITUITARY AUTOANTIBODY IN TWO PATIENTS WITH IMMUNE CHECKPOINT INHIBITOR-MEDIATED HYPOPHYSITIS: ZCCHC8. PMID:32671216
Brainstem Organoids From Human Pluripotent Stem Cells. PMID:32670003
PODXL2 maintains cellular stemness and promotes breast cancer development through the Rac1/Akt pathway. PMID:32669966
Radiosensitisation of Hepatocellular Carcinoma Cells by Vandetanib. PMID:32668592
Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing. PMID:32665542
SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis. PMID:32664949
Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells. PMID:32664515
miR-499a promotes PANC-1 cell proliferation by down-regulating PDCD4 expression in pancreatic ductal adenocarcinoma. PMID:32661474
Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis. PMID:32661137
Imputing missing RNA-sequencing data from DNA methylation by using a transfer learning-based neural network. PMID:32649756
SARS-CoV-2, ACE2, and Hydroxychloroquine: Cardiovascular Complications, Therapeutics, and Clinical Readouts in the Current Settings. PMID:32645974
Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome. PMID:32645919
Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis. PMID:32640634
Identification of the Combinatorial Effect of miRNA Family Regulatory Network in Different Growth Patterns of GC. PMID:32637572
A Comprehensive Proteomic SWATH-MS Workflow for Profiling Blood Extracellular Vesicles: A New Avenue for Glioma Tumour Surveillance. PMID:32635403
HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia. PMID:32634239
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections. PMID:32628701
Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits. PMID:32628676
Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells. PMID:32627867
Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities. PMID:32620753
Genes Regulated by HPV 16 E6 and High Expression of NFX1-123 in Cervical Cancers. PMID:32617009
Pituitary Disease in AIP Mutation-Positive Familial Isolated Pituitary Adenoma (FIPA): A Kindred-Based Overview. PMID:32604740
A Translational Pipeline for Overall Survival Prediction of Breast Cancer Patients by Decision-Level Integration of Multi-Omics Data. PMID:32601549
Identification of Prognostic Organic Cation and Anion Transporters in Different Cancer Entities by In Silico Analysis. PMID:32599841
LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway. PMID:32595998
IL-34 is a potential biomarker for the treatment of papillary thyroid cancer. PMID:32573824
PET imaging of soluble epoxide hydrolase in non-human primate brain with [18F]FNDP. PMID:32572592
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. PMID:32554929
The ITGB6 gene: its role in experimental and clinical biology. PMID:32550552
Systemic Proteome Alterations Linked to Early Stage Pancreatic Cancer in Diabetic Patients. PMID:32545216
Met-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations. PMID:32533056
Progesterone/Org inhibits lung adenocarcinoma cell growth via membrane progesterone receptor alpha. PMID:32529777
COVID-19: viral-host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection. PMID:32522207
Perithyroidal Salivary Gland Acinic Cell Carcinoma: Morphological and Molecular Attributes of a Unique Lesion. PMID:32519264
Downexpression of HSD17B6 correlates with clinical prognosis and tumor immune infiltrates in hepatocellular carcinoma. PMID:32514254
Low baseline pulmonary levels of cytotoxic lymphocytes as a predisposing risk factor for severe COVID-19. PMID:32511391
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint. PMID:32508832
Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned so Far. PMID:32498343
Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells. PMID:32492424
Tox21BodyMap: a webtool to map chemical effects on the human body. PMID:32491175
Prognostic gene expression signature revealed the involvement of mutational pathways in cancer genome. PMID:32489468
GLIS2 promotes colorectal cancer through repressing enhancer activation. PMID:32483180
Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis. PMID:32473614
Fractalkine/CX3CL1 in Neoplastic Processes. PMID:32466280
Identification of a Splenic Marginal Zone Lymphoma Signature: Preliminary Findings With Diagnostic Potential. PMID:32457837
A Peptide Link Between Human Cytomegalovirus Infection, Neuronal Migration, and Psychosis. PMID:32457660
Cysteine Cathepsins Inhibition Affects Their Expression and Human Renal Cancer Cell Phenotype. PMID:32455715
Deep-Learning-Based Characterization of Tumor-Infiltrating Lymphocytes in Breast Cancers From Histopathology Images and Multiomics Data. PMID:32453636
YAP1 Withdrawal in Hepatoblastoma Drives Therapeutic Differentiation of Tumor Cells to Functional Hepatocyte-Like Cells. PMID:32452550
Ras and Wnt Interaction Contribute in Prostate Cancer Bone Metastasis. PMID:32443915
Identifying Drug Targets in Pancreatic Ductal Adenocarcinoma Through Machine Learning, Analyzing Biomolecular Networks, and Structural Modeling. PMID:32425783
Radiolabeled cCPE Peptides for SPECT Imaging of Claudin-4 Overexpression in Pancreatic Cancer. PMID:32414951
Impact of Extracellular Matrix Components to Renal Cell Carcinoma Behavior. PMID:32411604
Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme. PMID:32392704
Identification of HMG-box family establishes the significance of SOX6 in the malignant progression of glioblastoma. PMID:32388501
Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. PMID:32382484
Comprehensive Analysis of Fibroblast Growth Factor Receptor (FGFR) Family Genes in Breast Cancer by Integrating Online Databases and Bioinformatics. PMID:32381997
The Impact of Transcription Factor Prospero Homeobox 1 on the Regulation of Thyroid Cancer Malignancy. PMID:32370142
Towards the routine use of in silico screenings for drug discovery using metabolic modelling. PMID:32369553
Genomic landscape of platinum resistant and sensitive testicular cancers. PMID:32366847
High Mobility Group AT-Hook 2 (HMGA2) Oncogenicity in Mesenchymal and Epithelial Neoplasia. PMID:32365712
ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance. PMID:32363112
Genome-Scale Metabolic Modeling of Glioblastoma Reveals Promising Targets for Drug Development. PMID:32362913
Investigating the effect of dependence between conditions with Bayesian Linear Mixed Models for motif activity analysis. PMID:32357166
Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer. PMID:32350277
Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis. PMID:32341162
The Oncogenic Role of CENPA in Hepatocellular Carcinoma Development: Evidence from Bioinformatic Analysis. PMID:32337237
Prognostic significance of age related genes in patients with lower grade glioma. PMID:32328202
Moesin (MSN) as a Novel Proteome-Based Diagnostic Marker for Early Detection of Invasive Bladder Urothelial Carcinoma in Liquid-Based Cytology. PMID:32326232
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression. PMID:32326089
Integrated analysis of the E2F transcription factors across cancer types. PMID:32323836
Quantitative SWATH-Based Proteomic Profiling for Identification of Mechanism-Driven Diagnostic Biomarkers Conferring in the Progression of Metastatic Prostate Cancer. PMID:32322560
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer. PMID:32322170
HECTD1 regulates the expression of SNAIL: Implications for epithelial‑mesenchymal transition. PMID:32319576
A novel 20-gene prognostic score in pancreatic adenocarcinoma. PMID:32310997
Midkine signaling maintains the self-renewal and tumorigenic capacity of glioma initiating cells. PMID:32308772
Mouse models of colorectal cancer: Past, present and future perspectives. PMID:32308343
CREB1 is affected by the microRNAs miR-22-3p, miR-26a-5p, miR-27a-3p, and miR-221-3p and correlates with adverse clinicopathological features in renal cell carcinoma. PMID:32300145
Molecular Targets for Combined Therapeutic Strategies to Limit Glioblastoma Cell Migration and Invasion. PMID:32292341
CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110. PMID:32264921
A Key mRNA-miRNA-lncRNA Competing Endogenous RNA Triple Sub-network Linked to Diagnosis and Prognosis of Hepatocellular Carcinoma. PMID:32257949
KRT17 Functions as a Tumor Promoter and Regulates Proliferation, Migration and Invasion in Pancreatic Cancer via mTOR/S6k1 Pathway. PMID:32256116
The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated? PMID:32255730
Nucleolin-Sle A Glycoforms as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer Cells. PMID:32252346
PRDM16 suppresses HIF-targeted gene expression in kidney cancer. PMID:32251515
Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells. PMID:32249776
A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation. PMID:32243780
Transcriptome analysis reveals gender-specific differences in overall metabolic response of male and female patients in lung adenocarcinoma. PMID:32236130
Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through unfolded protein response and EGFR-Akt pathway modulation. PMID:32235891
Transcriptome Ortholog Alignment Sequence Tools (TOAST) for phylogenomic dataset assembly. PMID:32228442
Suppression of TRPM7 Inhibited Hypoxia-Induced Migration and Invasion of Androgen-Independent Prostate Cancer Cells by Enhancing RACK1-Mediated Degradation of HIF-1α. PMID:32215176
OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine. PMID:32210335
RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors. PMID:32209086
Addressing the heterogeneity in liver diseases using biological networks. PMID:32201876
Pharmacological Modulation of SAMHD1 Activity by CDK4/6 Inhibitors Improves Anticancer Therapy. PMID:32197329
Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis. PMID:32195170
The Identification of Key Gene Expression Signature and Biological Pathways in Metastatic Renal Cell Carcinoma. PMID:32194783
MARCKSL1 promotes the proliferation, migration and invasion of lung adenocarcinoma cells. PMID:32194726
Integrated Analysis of the Functions and Prognostic Values of RNA Binding Proteins in Lung Squamous Cell Carcinoma. PMID:32194639
Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. PMID:32193359
Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and Wnt. PMID:32182224
Identification of key genes and pathways of diagnosis and prognosis in cervical cancer by bioinformatics analysis. PMID:32181600
The transcription factor CUX1 negatively regulates invasion in castrate resistant prostate cancer. PMID:32180898
Men1 maintains exocrine pancreas homeostasis in response to inflammation and oncogenic stress. PMID:32156729
Identification of Core Gene Expression Signature and Key Pathways in Colorectal Cancer. PMID:32153633
Functionally Enigmatic Genes in Cancer: Using TCGA Data to Map the Limitations of Annotations. PMID:32139709
Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis. PMID:32117966
EMT-related gene expression is positively correlated with immunity and may be derived from stromal cells in osteosarcoma. PMID:32117617
c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes. PMID:32117317
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex. PMID:32111735
Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover. PMID:32106628
Immune cell repertoires in breast cancer patients after adjuvant chemotherapy. PMID:32102986
Classification of clear cell renal cell carcinoma based on PKM alternative splicing. PMID:32095654
Pan-cancer mapping of differential protein-protein interactions. PMID:32094374
MMP24 as a Target of YAP is a Potential Prognostic Factor in Cancer Patients. PMID:32093160
Cytokine-Induced Guanylate Binding Protein 1 (GBP1) Release from Human Ovarian Cancer Cells. PMID:32093058
Epigenome-wide association study reveals a molecular signature of response to phylloquinone (vitamin K1) supplementation. PMID:32090699
ITGAV targeting as a therapeutic approach for treatment of metastatic breast cancer. PMID:32064162
Deletion of Von Hippel-Lindau Interferes with Hyper Osmolality Induced Gene Expression and Induces an Unfavorable Gene Expression Pattern. PMID:32059438
Restoration of MARCKS enhances chemosensitivity in cancer. PMID:32056006
YAP1 is an independent prognostic marker in pancreatic cancer and associated with extracellular matrix remodeling. PMID:32054505
Screening and Identification of Key Biomarkers for Bladder Cancer: A Study Based on TCGA and GEO Data. PMID:32047816
Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling. PMID:32042113
Comprehensive analysis of somatic copy number alterations in clear cell renal cell carcinoma. PMID:32039517
Analysis of the Differentially Expressed Genes Induced by Cisplatin Resistance in Oral Squamous Cell Carcinomas and Their Interaction. PMID:32038705
Reaction of carbon monoxide with cystathionine β-synthase: implications on drug efficacies in cancer chemotherapy. PMID:32031001
Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models. PMID:32024199
Exploring Metabolic Consequences of CPS1 and CAD Dysregulation in Hepatocellular Carcinoma by Network Reconstruction. PMID:32021853
PI3K in stemness regulation: from development to cancer. PMID:32010943
Complex impact of DNA methylation on transcriptional dysregulation across 22 human cancer types. PMID:32002550
The omics revolution: beyond genomics. A meeting report. PMID:31997976
Senescence-associated genes and non-coding RNAs function in pancreatic cancer progression. PMID:31997706
GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling. PMID:31989025
SETD2 mutation in renal clear cell carcinoma suppress autophagy via regulation of ATG12. PMID:31988284
Sterol O-Acyl Transferase 1 as a Prognostic Marker of Adrenocortical Carcinoma. PMID:31963898
Plasma Membrane Ca2+ ATPase Isoform 4 (PMCA4) Has an Important Role in Numerous Hallmarks of Pancreatic Cancer. PMID:31963119
MetaOmGraph: a workbench for interactive exploratory data analysis of large expression datasets. PMID:31956905
Pathway analysis of glutamate-mediated, calcium-related signaling in glioma progression. PMID:31954716
Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes. PMID:31953484
Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer. PMID:31945018
Chimeric oncolytic Ad5/3 virus replicates and lyses ovarian cancer cells through desmoglein-2 cell entry receptor. PMID:31944306
Emerging roles of IL-34 in health and disease. PMID:31940023
Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma. PMID:31939622
Sorafenib Inhibits Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in Hepatocellular Carcinoma Cells. PMID:31936661
Integrated assessment of CDK1 upregulation in thyroid cancer. PMID:31934275
Prognostic significance of BZW2 expression in lung adenocarcinoma patients. PMID:31933829
The clinicopathological significance of decreased miR-125b-5p in hepatocellular carcinoma: evidence based on RT-qPCR, microRNA-microarray, and microRNA-sequencing. PMID:31933718
Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes. PMID:31925297
LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer. PMID:31912669
RNA-Seq Analysis Identified XLOC_009190 as Potential Therapeutic Target for Lung Adenocarcinoma. PMID:31908488
Saga of Mcl-1: regulation from transcription to degradation. PMID:31907390
DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation. PMID:31907278
DDX3X Multifunctionally Modulates Tumor Progression and Serves as a Prognostic Indicator to Predict Cancer Outcomes. PMID:31906196
ASPM promotes glioblastoma growth by regulating G1 restriction point progression and Wnt-β-catenin signaling. PMID:31905171
Nuclear up regulation of the BRCA1-associated ubiquitinase BAP1 is associated with tumor aggressiveness in prostate cancers lacking the TMPRSS2:ERG fusion. PMID:31903168
PRAS40 hyperexpression promotes hepatocarcinogenesis. PMID:31901857
Harnessing big 'omics' data and AI for drug discovery in hepatocellular carcinoma. PMID:31900465
FNDC3B is associated with ER stress and poor prognosis in cervical cancer. PMID:31897153
Integrated profiling identifies SLC5A6 and MFAP2 as novel diagnostic and prognostic biomarkers in gastric cancer patients. PMID:31894266
Deletion of low-density lipoprotein-related receptor 5 inhibits liver Cancer cell proliferation via destabilizing Nucleoporin 37. PMID:31881970
Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer. PMID:31875161
A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice. PMID:31873789
Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer. PMID:31871120
Impact Effect of Methyl Tertiary-Butyl Ether "Twelve Months Vapor Inhalation Study in Rats". PMID:31861902
Finding prognostic gene pairs for cancer from patient-specific gene networks. PMID:31856825
Schlafen12 Reduces the Aggressiveness of Triple Negative Breast Cancer through Post-Transcriptional Regulation of ZEB1 That Drives Stem Cell Differentiation. PMID:31838790
MyoD1 suppresses cell migration and invasion by inhibiting FUT4 transcription in human gastric cancer cells. PMID:31831855
Secretome analysis of patient-derived GBM tumor spheres identifies midkine as a potent therapeutic target. PMID:31811117
Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer. PMID:31810358
USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer. PMID:31801945
Genetics and functions of the retinoic acid pathway, with special emphasis on the eye. PMID:31796115
Prognostic value and prospective molecular mechanism of miR-100-5p in hepatocellular carcinoma: A comprehensive study based on 1,258 samples. PMID:31788087
ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation. PMID:31782884
Cancer Stem Cells: Powerful Targets to Improve Current Anticancer Therapeutics. PMID:31781251
Characterization of Hepatocellular Carcinoma Cell Lines Using a Fractionation-Then-Sequencing Approach Reveals Nuclear-Enriched HCC-Associated lncRNAs. PMID:31781161
The multifaceted anti-cancer effects of BRAF-inhibitors. PMID:31762942
DNA Replication and Sister Chromatid Cohesion 1 (DSCC1) of the Replication Factor Complex CTF18-RFC is Critical for Colon Cancer Cell Growth. PMID:31762824
Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma. PMID:31744494
Comprehensive investigation of key biomarkers and pathways in hepatitis B virus-related hepatocellular carcinoma. PMID:31737106
Role of L-Type Amino Acid Transporter 1 (LAT1) for the Selective Cytotoxicity of Sesamol in Human Melanoma Cells. PMID:31717859
BioModels-15 years of sharing computational models in life science. PMID:31701150
Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells. PMID:31699970
TYK2: An Upstream Kinase of STATs in Cancer. PMID:31694222
GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies. PMID:31681577
Context-dependent roles of complement in cancer. PMID:31666715
Downregulation of GRK5 hampers the migration of breast cancer cells. PMID:31664083
PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance. PMID:31655611
MIC_Locator: a novel image-based protein subcellular location multi-label prediction model based on multi-scale monogenic signal representation and intensity encoding strategy. PMID:31655541
Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers. PMID:31637211
IHC Color Histograms for Unsupervised Ki67 Proliferation Index Calculation. PMID:31632956
Differential secretome of pancreatic cancer cells in serum-containing conditioned medium reveals CCT8 as a new biomarker of pancreatic cancer invasion and metastasis. PMID:31632196
Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress. PMID:31625393
Upregulation of C1-inhibitor in pancreatic cancer. PMID:31620245
Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis. PMID:31614548
Identification of RAD54 homolog B as a promising therapeutic target for breast cancer. PMID:31612045
A comprehensive expression landscape of RNA-binding proteins (RBPs) across 16 human cancer types. PMID:31607220
High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer. PMID:31606028
Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages. PMID:31602788
Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis. PMID:31602402
CancerGeneNet: linking driver genes to cancer hallmarks. PMID:31598703
Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer. PMID:31596905
A clonal expression biomarker associates with lung cancer mortality. PMID:31591602
MutEx: a multifaceted gateway for exploring integrative pan-cancer genomic data. PMID:31588509
CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma. PMID:31584877
Role of miR-10b-5p in the prognosis of breast cancer. PMID:31579605
Novel human Ab against vascular endothelial growth factor receptor 2 shows therapeutic potential for leukemia and prostate cancer. PMID:31578782
MicroRNA-424 regulates cisplatin resistance of gastric cancer by targeting SMURF1 based on GEO database and primary validation in human gastric cancer tissues. PMID:31571913
Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling. PMID:31568691
Update on the synergistic effect of HSL and insulin in the treatment of metabolic disorders. PMID:31565213
Zeta-crystallin: a moonlighting player in cancer. PMID:31563996
Common Nevus and Skin Cutaneous Melanoma: Prognostic Genes Identified by Gene Co-Expression Network Analysis. PMID:31557882
SIDT2 RNA Transporter Promotes Lung and Gastrointestinal Tumor Development. PMID:31546103
Myeloid cell-synthesized coagulation factor X dampens antitumor immunity. PMID:31541031
USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity. PMID:31527800
Treating Cancer as an Invasive Species. PMID:31527151
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites. PMID:31519908
Expression of Oncogenic Drivers in 3D Cell Culture Depends on Nuclear ATP Synthesis by NUDT5. PMID:31510016
The Cancer-Associated Genetic Variant Rs3903072 Modulates Immune Cells in the Tumor Microenvironment. PMID:31507631
Editorial: A Novel Monoclonal Antibody-Targeting Angiogenesis by Inhibiting Secreted Frizzled-Related Protein 2. PMID:31502016
Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling. PMID:31501550
HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. PMID:31500569
Discovering human transcription factor physical interactions with genetic variants, novel DNA motifs, and repetitive elements using enhanced yeast one-hybrid assays. PMID:31481462
Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Therapeutic Targets. PMID:31475119
DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases. PMID:31467668
Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27Kip1 signaling axis. PMID:31457089
Progress on Identifying and Characterizing the Human Proteome: 2019 Metrics from the HUPO Human Proteome Project. PMID:31430157
Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer. PMID:31429779
Gene Expression Profiling Analysis Reveals Putative Phytochemotherapeutic Target for Castration-Resistant Prostate Cancer. PMID:31428582
Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells. PMID:31428460
TGF-β-induced transgelin promotes bladder cancer metastasis by regulating epithelial-mesenchymal transition and invadopodia formation. PMID:31420300
Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic Modeling. PMID:31417867
The proteome and its dynamics: A missing piece for integrative multi-omics in schizophrenia. PMID:31416743
Application of the High-throughput TAB-Array for the Discovery of Novel 5-Hydroxymethylcytosine Biomarkers in Pancreatic Ductal Adenocarcinoma. PMID:31413874
Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression. PMID:31411736
Identification of hyper-rewired genomic stress non-oncogene addiction genes across 15 cancer types. PMID:31396397
Identification and Clinical Validation of a Novel 4 Gene-Signature with Prognostic Utility in Colorectal Cancer. PMID:31387239
A serum protein signature of APOE genotypes in centenarians. PMID:31385390
EZH2 Phosphorylation Promotes Self-Renewal of Glioma Stem-Like Cells Through NF-κB Methylation. PMID:31380279
Chemerin and Cancer. PMID:31370263
Targeting Mechanoresponsive Proteins in Pancreatic Cancer: 4-Hydroxyacetophenone Blocks Dissemination and Invasion by Activating MYH14. PMID:31358530
Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis. PMID:31357676
Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome. PMID:31353912
Defining Protein Pattern Differences Among Molecular Subtypes of Diffuse Gliomas Using Mass Spectrometry. PMID:31353322
CSF-1 controls cerebellar microglia and is required for motor function and social interaction. PMID:31350310
The Gene Master Regulators (GMR) Approach Provides Legitimate Targets for Personalized, Time-Sensitive Cancer Gene Therapy. PMID:31349573
Beyond N-Cadherin, Relevance of Cadherins 5, 6 and 17 in Cancer Progression and Metastasis. PMID:31324051
Identifying potential drug targets in hepatocellular carcinoma based on network analysis and one-class support vector machine. PMID:31320657
Clinical update on head and neck cancer: molecular biology and ongoing challenges. PMID:31308358
Redox signals at the ER-mitochondria interface control melanoma progression. PMID:31304984
Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration. PMID:31302749
Correlation Analysis of Histopathology and Proteogenomics Data for Breast Cancer. PMID:31285282
Human Systems Biology and Metabolic Modelling: A Review-From Disease Metabolism to Precision Medicine. PMID:31281846
The role of clonal communication and heterogeneity in breast cancer. PMID:31277602
Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study. PMID:31277479
[Medium-chain acyl-CoA dehydrogenase enhances invasion and metastasis ability of breast cancer cells]. PMID:31270042
Integrating proteomics and transcriptomics for the identification of potential targets in early colorectal cancer. PMID:31268166
COL6A1 promotes metastasis and predicts poor prognosis in patients with pancreatic cancer. PMID:31268154
Single-cell RNA-seq variant analysis for exploration of genetic heterogeneity in cancer. PMID:31267007
TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer. PMID:31262711
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation. PMID:31253574
Leveraging the Role of the Metastatic Associated Protein Anterior Gradient Homologue 2 in Unfolded Protein Degradation: A Novel Therapeutic Biomarker for Cancer. PMID:31247903
miR-6716-5p promotes metastasis of colorectal cancer through downregulating NAT10 expression. PMID:31239781
Transcriptomic Differences between Primary Colorectal Adenocarcinomas and Distant Metastases Reveal Metastatic Colorectal Cancer Subtypes. PMID:31239274
CNBP controls transcription by unfolding DNA G-quadruplex structures. PMID:31219592
Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective. PMID:31216675
PP2A: A Promising Biomarker and Therapeutic Target in Endometrial Cancer. PMID:31214504
The gene regulatory basis of genetic compensation during neural crest induction. PMID:31199790
Gene Expression Indicates Altered Immune Modulation and Signaling Pathway Activation in Ovarian Cancer Patients Resistant to Topotecan. PMID:31195594
Overexpression of NCAPH is upregulated and predicts a poor prognosis in prostate cancer. PMID:31186803
Identification of CTRP1 as a Prognostic Biomarker and Oncogene in Human Glioblastoma. PMID:31183364
Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression. PMID:31171768
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. PMID:31160565
STAG2 loss-of-function mutation induces PD-L1 expression in U2OS cells. PMID:31157248
Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer. PMID:31137727
Epigenetic-Mediated Downregulation of Zinc Finger Protein 671 (ZNF671) Predicts Poor Prognosis in Multiple Solid Tumors. PMID:31134149
Multi-Omic Data Interpretation to Repurpose Subtype Specific Drug Candidates for Breast Cancer. PMID:31134131
Pan-cancer analysis connects tumor matrisome to immune response. PMID:31123708
Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses. PMID:31116490
GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. PMID:31114875
Urinary peptide panel for prognostic assessment of bladder cancer relapse. PMID:31114012
Overexpression of ASPM, CDC20, and TTK Confer a Poorer Prognosis in Breast Cancer Identified by Gene Co-expression Network Analysis. PMID:31106147
Secretomes from metastatic breast cancer cells, enriched for a prognostically unfavorable LCN2 axis, induce anti-inflammatory MSC actions and a tumor-supportive premetastatic lung. PMID:31105883
Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling. PMID:31101498
Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis. PMID:31100640
Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice. PMID:31100067
The prognostic values of matrix metalloproteinases in ovarian cancer. PMID:31099295
Enhanced metastatic potential in the MB49 urothelial carcinoma model. PMID:31092844
Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells. PMID:31068932
Prospective molecular mechanism of COL5A1 in breast cancer based on a microarray, RNA sequencing and immunohistochemistry. PMID:31059074
A Unique Family of Neuronal Signaling Proteins Implicated in Oncogenesis and Tumor Suppression. PMID:31058089
Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. PMID:31057295
Biological Insights into Chemotherapy Resistance in Ovarian Cancer. PMID:31052165
The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State. PMID:31048499
Exploration of prognosis-related microRNA and transcription factor co-regulatory networks across cancer types. PMID:31046554
Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling. PMID:31035605
The Identification of Potential Biomarkers and Biological Pathways in Prostate Cancer. PMID:31031850
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities. PMID:31031003
Altered Expression of DDR1 in Clear Cell Renal Cell Carcinoma Correlates With miR-199a/b-5p and Patients' Outcome. PMID:31018949
Promotion of growth factor signaling as a critical function of β-catenin during HCC progression. PMID:31015417
Genome-Wide CRISPR Screen Reveals Autophagy Disruption as the Convergence Mechanism That Regulates the NRF2 Transcription Factor. PMID:31010806
First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent. PMID:30996782
CDK11 Loss Induces Cell Cycle Dysfunction and Death of BRAF and NRAS Melanoma Cells. PMID:30987032
Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies. PMID:30974124
Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner. PMID:30971297
Interleukin 32 expression in human melanoma. PMID:30953519
BZW2 gene knockdown induces cell growth inhibition, G1 arrest and apoptosis in muscle-invasive bladder cancers: A microarray pathway analysis. PMID:30932331
Improved survival prognostication of node-positive malignant melanoma patients utilizing shotgun proteomics guided by histopathological characterization and genomic data. PMID:30914758
Liver Cancer Gene Discovery Using Gene Targeting, Sleeping Beauty, and CRISPR/Cas9. PMID:30912094
Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning. PMID:30905848
Differentially expressed gene profile and relevant pathways of the traditional Chinese medicine cinobufotalin on MCF‑7 breast cancer cells. PMID:30896874
PTEN arginine methylation by PRMT6 suppresses PI3K-AKT signaling and modulates pre-mRNA splicing. PMID:30886105
A toolset to study functions of Cytosolic non-specific dipeptidase 2 (CNDP2) using Drosophila as a model organism. PMID:30885138
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma. PMID:30872592
The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expression. PMID:30867900
Aberrant DOCK2, GRASP, HIF3A and PKFP Hypermethylation has Potential as a Prognostic Biomarker for Prostate Cancer. PMID:30866497
Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone. PMID:30855230
Differential metabolic activity and discovery of therapeutic targets using summarized metabolic pathway models. PMID:30854222
Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis. PMID:30845770
A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome. PMID:30840886
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion. PMID:30836712
Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide. PMID:30823646
Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail. PMID:30818851
Connexins in cancer: bridging the gap to the clinic. PMID:30814684
MTA2-mediated inhibition of PTEN leads to pancreatic ductal adenocarcinoma carcinogenicity. PMID:30814496
Radiogenomic Analysis of F-18-Fluorodeoxyglucose Positron Emission Tomography and Gene Expression Data Elucidates the Epidemiological Complexity of Colorectal Cancer Landscape. PMID:30809322
CXCR7 promotes melanoma tumorigenesis via Src kinase signaling. PMID:30804329
The prognostic landscape of interactive biological processes presents treatment responses in cancer. PMID:30799199
LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway. PMID:30791942
Comprehensive clinical implications of homeobox A10 in 3,199 cases of non-small cell lung cancer tissue samples combining qRT-PCR, RNA sequencing and microarray data. PMID:30787969
Machine learning analysis of gene expression data reveals novel diagnostic and prognostic biomarkers and identifies therapeutic targets for soft tissue sarcomas. PMID:30785874
New guidelines for DNA methylome studies regarding 5-hydroxymethylcytosine for understanding transcriptional regulation. PMID:30782641
The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation. PMID:30770239
Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring. PMID:30768568
Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions. PMID:30765704
Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment. PMID:30760718
The anti-cancer drug 5-fluorouracil affects cell cycle regulators and potential regulatory long non-coding RNAs in yeast. PMID:30760080
SAMD5 mRNA was overexpressed in prostate cancer and can predict biochemical recurrence after radical prostatectomy. PMID:30739268
Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells. PMID:30729097
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules. PMID:30693281
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. PMID:30692626
Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents. PMID:30689188
Redox inhibition of protein phosphatase PP2A: Potential implications in oncogenesis and its progression. PMID:30686777
Neuroblastoma RAS Viral Oncogene Homolog (NRAS) Is a Novel Prognostic Marker and Contributes to Sorafenib Resistance in Hepatocellular Carcinoma. PMID:30685691
Discovery of KIRREL as a biomarker for prognostic stratification of patients with thin melanoma. PMID:30675360
Integrating clinical, molecular, proteomic and histopathological data within the tissue context: tissunomics. PMID:30667539
miR663a‑TTC22V1 axis inhibits colon cancer metastasis. PMID:30664167
EFNB2 acts as the target of miR-557 to facilitate cell proliferation, migration and invasion in pancreatic ductal adenocarcinoma by bioinformatics analysis and verification. PMID:30662604
Spatial proteomics: a powerful discovery tool for cell biology. PMID:30659282
LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer. PMID:30653260
Uterine double-conditional inactivation of Smad2 and Smad3 in mice causes endometrial dysregulation, infertility, and uterine cancer. PMID:30651315
Alterations in the glycome after HDAC inhibition impact oncogenic potential in epigenetically plastic SW13 cells. PMID:30651077
High KRT8 Expression Independently Predicts Poor Prognosis for Lung Adenocarcinoma Patients. PMID:30634629
Targeted Delivery to Tumors: Multidirectional Strategies to Improve Treatment Efficiency. PMID:30634580
Integrated Analysis of MicroRNA (miRNA) and mRNA Profiles Reveals Reduced Correlation between MicroRNA and Target Gene in Cancer. PMID:30627543
Variations in HPV function are associated with survival in squamous cell carcinoma. PMID:30626753
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. PMID:30619488
Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis. PMID:30606699
Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter. PMID:30600259
Classification of Widely and Rarely Expressed Genes with Recurrent Neural Network. PMID:30595815
Knockout of MTF1 Inhibits the Epithelial to Mesenchymal Transition in Ovarian Cancer Cells. PMID:30588241
RNA element discovery from germ cell to blastocyst. PMID:30576549
High-resolution mapping of cancer cell networks using co-functional interactions. PMID:30573688
Alteration of tumor suppressor BMP5 in sporadic colorectal cancer: a genomic and transcriptomic profiling based study. PMID:30572883
Role of oxidative stress in Retinitis pigmentosa: new involved pathways by an RNA-Seq analysis. PMID:30569795
ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma. PMID:30556643
The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction. PMID:30530495
Systematic identification of mutations and copy number alterations associated with cancer patient prognosis. PMID:30526857
Nonalcoholic Fatty Liver Disease Demonstrates a Pre-fibrotic and Premalignant Molecular Signature. PMID:30519850
RBMS2 inhibits the proliferation by stabilizing P21 mRNA in breast cancer. PMID:30514345
The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes. PMID:30504233
Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes. PMID:30482855
STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability. PMID:30482772
Data-Independent Acquisition Mass Spectrometry To Quantify Protein Levels in FFPE Tumor Biopsies for Molecular Diagnostics. PMID:30481034
Dissecting the Immune Landscape of Acute Myeloid Leukemia. PMID:30477280
Analysis of regulator of G-protein signalling 2 (RGS2) expression and function during prostate cancer progression. PMID:30467386
Crystal structure of human vaccinia-related kinase 1 in complex with AMP-PNP, a non-hydrolyzable ATP analog. PMID:30461091
The poly-omics of ageing through individual-based metabolic modelling. PMID:30453872
MitoMiner v4.0: an updated database of mitochondrial localization evidence, phenotypes and diseases. PMID:30398659
Solute Carrier Family 27 Member 4 (SLC27A4) Enhances Cell Growth, Migration, and Invasion in Breast Cancer Cells. PMID:30388870
Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells. PMID:30385729
TransmiR v2.0: an updated transcription factor-microRNA regulation database. PMID:30371815
Characteristics of the tissue section that influence the staining outcome in immunohistochemistry. PMID:30357509
Genetic expression profile-based screening of genes and pathways associated with papillary thyroid carcinoma. PMID:30344727
Promoter Methylation-Regulated miR-145-5p Inhibits Laryngeal Squamous Cell Carcinoma Progression by Targeting FSCN1. PMID:30341010
Novel MXD4-NUTM1 fusion transcript identified in primary ovarian undifferentiated small round cell sarcoma. PMID:30338611
Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome. PMID:30333754
ESS: A Tool for Genome-Scale Quantification of Essentiality Score for Reaction/Genes in Constraint-Based Modeling. PMID:30323767
Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN-FOS at composite DNA sites. PMID:30315111
Clinical trials involving carbon-ion radiation therapy and the path forward. PMID:30307603
A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein. PMID:30279450
HCCDB: A Database of Hepatocellular Carcinoma Expression Atlas. PMID:30266410
Integrated analysis of transcription factors and targets co-expression profiles reveals reduced correlation between transcription factors and target genes in cancer. PMID:30251028
Identification of potential biomarkers in cervical cancer with combined public mRNA and miRNA expression microarray data analysis. PMID:30250588
A meta-analysis and bioinformatics exploration of the diagnostic value and molecular mechanism of miR-193a-5p in lung cancer. PMID:30250529
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. PMID:30250201
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome. PMID:30242179
Multimodal Meta-Analysis of 1,494 Hepatocellular Carcinoma Samples Reveals Significant Impact of Consensus Driver Genes on Phenotypes. PMID:30242023
Absence of AIF1L contributes to cell migration and a poor prognosis of breast cancer. PMID:30233209
Contribution of allelic imbalance to colorectal cancer. PMID:30202008
FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1, and cell cycle pathways in mouse Leydig tumor cells. PMID:30191630
Joint profiling of chromatin accessibility and gene expression in thousands of single cells. PMID:30166440
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. PMID:30127393
Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma. PMID:30125264
Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project. PMID:30099871
A k-mer based transcriptomics approach for antisense drug discovery targeting the Ewing's family of tumors. PMID:30093970
Proteomic distinction of renal oncocytomas and chromophobe renal cell carcinomas. PMID:30087584
CTCF maintains regulatory homeostasis of cancer pathways. PMID:30086769
Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice. PMID:30086728
Metabolic Network-Based Identification and Prioritization of Anticancer Targets Based on Expression Data in Hepatocellular Carcinoma. PMID:30065658
Biomarkers of Duchenne muscular dystrophy: current findings. PMID:30050384
Identification of integrin drug targets for 17 solid tumor types. PMID:30046394
Analysis of public RNA-sequencing data reveals biological consequences of genetic heterogeneity in cell line populations. PMID:30046134
Liver-enriched Genes are Associated with the Prognosis of Patients with Hepatocellular Carcinoma. PMID:30046116
Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation. PMID:30044385
Regulation of the oncogenic phenotype by the nuclear body protein ZC3H8. PMID:30041613
CAD/POLD2 gene expression is associated with poor overall survival and chemoresistance in bladder urothelial carcinoma. PMID:30038717
VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival. PMID:30027561
Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population. PMID:30012096
Role of hepatoma-derived growth factor in promoting de novo lipogenesis and tumorigenesis in hepatocellular carcinoma. PMID:30004626
Understanding the Representative Gut Microbiota Dysbiosis in Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic Modeling. PMID:29988585
The Identification of Core Gene Expression Signature in Hepatocellular Carcinoma. PMID:29977454
Epimutation and Cancer: Carcinogenesis Viewed as Error-Prone Inheritance of Epigenetic Information. PMID:29971105
Determination of Tumor Margins with Surgical Specimen Mapping Using Near-Infrared Fluorescence. PMID:29967260
Expression of 4E-BP1 and phospho-4E-BP1 correlates with the prognosis of patients with clear cell renal carcinoma. PMID:29942157
Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity. PMID:29938858
Resolution Matters: Correlating Quantitative Proteomics and Nanoscale-Precision Microscopy for Reconstructing Synapse Identity. PMID:29932496
PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology. PMID:29930084
Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors. PMID:29925909
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity. PMID:29925878
TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association. PMID:29921235
Proteome-wide analysis of protein abundance and turnover remodelling during oncogenic transformation of human breast epithelial cells. PMID:29904729
Designer Oncolytic Adenovirus: Coming of Age. PMID:29904022
Re-Evaluating E-Cadherin and β-Catenin: A Pan-Cancer Proteomic Approach with an Emphasis on Breast Cancer. PMID:29879416
Chromatin Landscape Distinguishes the Genomic Loci of Hundreds of Androgen-Receptor-Associated LincRNAs From the Loci of Non-associated LincRNAs. PMID:29875794
Gene expression and prognosis of NOX family members in gastric cancer. PMID:29872318
Comparison of tumor related signaling pathways with known compounds to determine potential agents for lung adenocarcinoma. PMID:29870138
Drug Repositioning for Effective Prostate Cancer Treatment. PMID:29867548
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like family genes activation and regulation during tumorigenesis. PMID:29856501
Overactivated neddylation pathway in human hepatocellular carcinoma. PMID:29846044
A blueprint for human whole-cell modeling. PMID:29806041
Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment. PMID:29784973
Targeting invadopodia-mediated breast cancer metastasis by using ABL kinase inhibitors. PMID:29774130
NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes. PMID:29759984
Aberrant S100A16 expression might be an independent prognostic indicator of unfavorable survival in non-small cell lung adenocarcinoma. PMID:29746588
UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. PMID:29743725
Transcellular transport of cobalamin in aortic endothelial cells. PMID:29741927
Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells. PMID:29729928
Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma. PMID:29728763
The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway. PMID:29722127
Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources. PMID:29695735
Overview on Clinical Relevance of Intra-Tumor Heterogeneity. PMID:29682505
Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival. PMID:29682330
PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin β2 expression. PMID:29669796
In silico cancer research towards 3R. PMID:29649981
Identification of Prognostic Biomarkers by Combined mRNA and miRNA Expression Microarray Analysis in Pancreatic Cancer. PMID:29631214
Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis. PMID:29546479
The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis. PMID:29515971
Enhanced IL-34 expression in Nivolumab-resistant metastatic melanoma. PMID:29515691
Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis. PMID:29515119
Protein kinase C: perfectly balanced. PMID:29513138
Carbonic Anhydrases: Role in pH Control and Cancer. PMID:29495652
Adhesion GPCRs in Kidney Development and Disease. PMID:29468160
Mechanisms of Pulmonary Escape and Dissemination by Cryptococcus neoformans. PMID:29463005
Capping protein regulates actin dynamics during cytokinetic midbody maturation. PMID:29439200
Gene master regulators of papillary and anaplastic thyroid cancers. PMID:29416781
Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction. PMID:29416706
Lnc2Catlas: an atlas of long noncoding RNAs associated with risk of cancers. PMID:29382910
Glypican-1 immunohistochemistry is a novel marker to differentiate epithelioid mesothelioma from lung adenocarcinoma. PMID:29327712
Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. PMID:29301960
Protein Kinase A Distribution Differentiates Human Glioblastoma from Brain Tissue. PMID:29267253
Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer. PMID:29136504
Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer. PMID:29112949
BioModels: expanding horizons to include more modelling approaches and formats. PMID:29106614
KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops. PMID:29079305
TCSBN: a database of tissue and cancer specific biological networks. PMID:29069445
The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance. PMID:29064388
Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells. PMID:29049318
The human protein atlas: A spatial map of the human proteome. PMID:28940711 -
Towards a knowledge-based Human Protein Atlas
PubMed citations: 1089.
1089 articles citing: Towards a knowledge-based Human Protein Atlas
Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas. PMID:35906698
A Novel Necroptosis-Related Gene Signature in Skin Cutaneous Melanoma Prognosis and Tumor Microenvironment. PMID:35899194
Whole-body metabolic modelling predicts isoleucine dependency of SARS-CoV-2 replication. PMID:35874091
AI-enabled image fraud in scientific publications. PMID:35845832
Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: A key therapeutic target and biomarker in head and neck squamous cell carcinoma. PMID:35837069
HumanMine: advanced data searching, analysis and cross-species comparison. PMID:35820040
Prognostic Value of Stem Cell Index-Related Characteristics in Primary Hepatocellular Carcinoma. PMID:35800238
Formulation of an ovarian cancer vaccine with the squalene-based AddaVax adjuvant inhibits the growth of murine epithelial ovarian carcinomas. PMID:35799868
HS3ST2 expression induces the cell autonomous aggregation of tau. PMID:35760982
NCOA4: An Immunomodulation-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer. PMID:35756082
ASPM and TROAP gene expression as potential malignant tumor markers. PMID:35722431
The Correlation Between Immune Invasion and SARS-COV-2 Entry Protein ADAM17 in Cancer Patients by Bioinformatic Analysis. PMID:35720350
Development of a physiological insulin resistance model in human stem cell-derived adipocytes. PMID:35714187
Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging. PMID:35705636
SCAMP3 Regulates EGFR and Promotes Proliferation and Migration of Triple-Negative Breast Cancer Cells through the Modulation of AKT, ERK, and STAT3 Signaling Pathways. PMID:35681787
Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity. PMID:35625806
Antioxidant and Neuroprotective Effects of Carnosine: Therapeutic Implications in Neurodegenerative Diseases. PMID:35624713
Pan-cancer analyses reveal the genetic and pharmacogenomic landscape of transient receptor potential channels. PMID:35614079
Procollagen C-protease enhancer protein is a prognostic factor for glioma and promotes glioma development by regulating multiple tumor-related pathways and immune microenvironment. PMID:35609253
FLG Is a Potential Biomarker of Prognosis and Immunotherapy in Skin Cutaneous Melanoma. PMID:35607429
Using Weighted Gene Co-Expression Network Analysis to Identify Increased MND1 Expression as a Predictor of Poor Breast Cancer Survival. PMID:35601002
Immune Infiltration Characteristics and a Gene Prognostic Signature Associated With the Immune Infiltration in Head and Neck Squamous Cell Carcinoma. PMID:35586567
Soluble HLA peptidome of pleural effusions is a valuable source for tumor antigens. PMID:35580925
Mitochondrial transcription factor B2 overexpression increases M2 macrophage infiltration via cytosolic mitochondrial DNA-stimulated Interleukin-6 secretion in ovarian cancer. PMID:35577351
Updated Functional Roles of NAMPT in Carcinogenesis and Therapeutic Niches. PMID:35565188
Assessing the Potential Prognostic and Immunological Role of TK1 in Prostate Cancer. PMID:35559045
U2 small nuclear RNA auxiliary factor 2, transcriptionally activated by the transcription factor Dp-1/E2F transcription factor 1 complex, enhances the growth and aerobic glycolysis of leiomyosarcoma cells. PMID:35502531
Pan‑cancer analyses reveal the regulation and clinical outcome association of PCLAF in human tumors. PMID:35425993
Hypothetical protein predicted to be tumor suppressor: a protein functional analysis. PMID:35399005
Knowledge Graphs for Indication Expansion: An Explainable Target-Disease Prediction Method. PMID:35360842
Construction and Validation of Two Hepatocellular Carcinoma-Progression Prognostic Scores Based on Gene Set Variation Analysis. PMID:35356272
Comparing Urinary Glycoproteins among Three Urogenital Cancers and Identifying Prostate Cancer-Specific Glycoproteins. PMID:35350332
Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding. PMID:35333583
The Prognostic Role of CDK9 in Bladder Cancer. PMID:35326643
Detection of copy number variants and genes by chromosomal microarray in an Emirati neurodevelopmental disorders cohort. PMID:35325322
Prognostic and biological role of the N-Myc downstream-regulated gene family in hepatocellular carcinoma. PMID:35321174
UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization. PMID:35313791
Comprehensive Analysis of the Expression and Clinical Significance of THO Complex Members in Hepatocellular Carcinoma. PMID:35300138
Detection of Circulating and Disseminated Tumor Cells and Their Prognostic Value under the Influence of Neoadjuvant Therapy in Esophageal Cancer Patients. PMID:35267585
Host-microbiome protein-protein interactions capture disease-relevant pathways. PMID:35246229
Investigation of an FGFR-Signaling-Related Prognostic Model and Immune Landscape in Head and Neck Squamous Cell Carcinoma. PMID:35237609
Identification of CCL19 as a Novel Immune-Related Biomarker in Diabetic Nephropathy. PMID:35222545
BEND4 as a Candidate Gene for an Infection-Induced Acute Encephalopathy Characterized by a Cyst and Calcification of the Pons and Cerebellar Atrophy. PMID:35221871
The Expression Quantitative Trait Loci in Immune Response Genes Impact the Characteristics and Survival of Colorectal Cancer. PMID:35204406
A Comprehensive Prognostic Analysis of POLD1 in Hepatocellular Carcinoma. PMID:35189839
MYB proto-oncogene like 2 promotes hepatocellular carcinoma growth and glycolysis via binding to the Optic atrophy 3 promoter and activating its expression. PMID:35176941
Network Pharmacology- and Molecular Docking-Based Identification of Potential Phytocompounds from Argyreia capitiformis in the Treatment of Inflammation. PMID:35140801
Gemcitabine-Resistant Biomarkers in Bladder Cancer are Associated with Tumor-Immune Microenvironment. PMID:35127724
Enhancer RNA LINC00242-Induced Expression of PHF10 Drives a Better Prognosis in Pancreatic Adenocarcinoma. PMID:35127503
Multi-omics analysis reveals the BRCA1 mutation and mismatch repair gene signatures associated with survival, protein expression, and copy number alterations in prostate cancer. PMID:35116870
Survival-based bioinformatics analysis to identify hub genes and key pathways in non-small cell lung cancer. PMID:35116861
Sideroflexin1 as a novel tumor marker independently predicts survival in lung adenocarcinoma. PMID:35116859
The role of NLRP3 in the prognosis and immune infiltrates of skin cutaneous melanoma (SKCM). PMID:35116494
Gene expression profile of THZ1-treated nasopharyngeal carcinoma cell lines indicates its involvement in the inhibition of the cell cycle. PMID:35116274
ZERO-INFLATED QUANTILE RANK-SCORE BASED TEST (ZIQRANK) WITH APPLICATION TO SCRNA-SEQ DIFFERENTIAL GENE EXPRESSION ANALYSIS. PMID:35116085
Proteomic profiles in cerebrospinal fluid predicted death and disability in term infants with perinatal asphyxia: A pilot study. PMID:35106835
Signatures of malignant cells and novel therapeutic targets revealed by single-cell sequencing in lung adenocarcinoma. PMID:35102706
Mechanisms contributing to adverse outcomes of COVID-19 in obesity. PMID:35084674
Whole-Tissue Deconvolution and scRNAseq Analysis Identify Altered Endometrial Cellular Compositions and Functionality Associated With Endometriosis. PMID:35069565
TDP-43 Cytoplasmic Translocation in the Skin Fibroblasts of ALS Patients. PMID:35053327
HSP90 promotes radioresistance of cervical cancer cells via reducing FBXO6-mediated CD147 polyubiquitination. PMID:35043518
Association between Arsenic Level, Gene Expression in Asian Population, and In Vitro Carcinogenic Bladder Tumor. PMID:35039759
Exploiting protein family and protein network data to identify novel drug targets for bladder cancer. PMID:35035776
Interpretable Autoencoders Trained on Single Cell Sequencing Data Can Transfer Directly to Data from Unseen Tissues. PMID:35011647
Novel Molecular Targets for Hepatocellular Carcinoma. PMID:35008303
Identification and Mechanism of the PD-1/PD-L1 Genomic Signature SORL1 as Protective Factor in Bladder Cancer. PMID:34976002
A Novel Gene Prognostic Signature Based on Differential DNA Methylation in Breast Cancer. PMID:34956313
Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer's Disease. PMID:34948414
Mapping the Melanoma Plasma Proteome (MPP) Using Single-Shot Proteomics Interfaced with the WiMT Database. PMID:34944842
Reduction of Rapid Proliferating Tumour Cell Lines by Inhibition of the Specific Glycine Transporter GLYT1. PMID:34944586
Comprehensive Analysis Identified ETV7 as a Potential Prognostic Biomarker in Bladder Cancer. PMID:34926692
CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications. PMID:34925370
Unifying heterogeneous expression data to predict targets for CAR-T cell therapy. PMID:34858726
Applications of CRISPR-Cas Technologies to Proteomics. PMID:34828396
Computer-Aided Design for Identifying Anticancer Targets in Genome-Scale Metabolic Models of Colon Cancer. PMID:34827109
Prognostic Significance of TLR2, SMAD3 and Localization-dependent SATB1 in Stage I and II Non-Small-Cell Lung Cancer Patients. PMID:34818944
ATIC inhibits autophagy in hepatocellular cancer through the AKT/FOXO3 pathway and serves as a prognostic signature for modeling patient survival. PMID:34803509
Low-Input RNA-Sequencing in Patients with Cartilage Lesions, Osteoarthritis, and Healthy Cartilage. PMID:34775802
Prognostic biomarkers for predicting papillary thyroid carcinoma patients at high risk using nine genes of apoptotic pathway. PMID:34767591
1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development. PMID:34762852
3-D vascularized breast cancer model to study the role of osteoblast in formation of a pre-metastatic niche. PMID:34754042
Approximate distance correlation for selecting highly interrelated genes across datasets. PMID:34752449
SPTBN2, a New Biomarker of Lung Adenocarcinoma. PMID:34745988
Down-Regulated CLDN10 Predicts Favorable Prognosis and Correlates With Immune Infiltration in Gastric Cancer. PMID:34721537
Non-Invasive Characterization of the Pancreas During Bariatric Surgery via Circulating Pancreatic Specific Cell-free Messenger RNA. PMID:34707641
Construct a Knowledge Graph for China Coronavirus (COVID-19) Patient Information Tracking. PMID:34707418
BAF45b Is Required for Efficient Zika Virus Infection of HAP1 Cells. PMID:34696437
Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. PMID:34675202
The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis. PMID:34669700
Notch signaling in oral pre-cancer and oral cancer. PMID:34633549
Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection. PMID:34621686
Drivers of transcriptional variance in human intestinal epithelial organoids. PMID:34612061
miRNATissueAtlas2: an update to the human miRNA tissue atlas. PMID:34570238
Inflammatory signature in acute-on-chronic liver failure includes increased expression of granulocyte genes ELANE, MPO and CD177. PMID:34552111
Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer's disease. PMID:34514662
Intersection of Redox Chemistry and Ubiquitylation: Post-Translational Modifications Required for Maintaining Cellular Homeostasis and Neuroprotection. PMID:34440890
Molecular Pathways Involved in the Development of Congenital Erythrocytosis. PMID:34440324
Survival-Based Biomarker Module Identification Associated with Oral Squamous Cell Carcinoma (OSCC). PMID:34439992
Basic principles of hydrogel-based tissue transformation technologies and their applications. PMID:34358468
Alterations in plasma hyaluronic acid in patients with clinically stable COPD versus (non)smoking controls. PMID:34354097
Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice. PMID:34340748
PScL-HDeep: image-based prediction of protein subcellular location in human tissue using ensemble learning of handcrafted and deep learned features with two-layer feature selection. PMID:34337652
High-Density Blood Transcriptomics Reveals Precision Immune Signatures of SARS-CoV-2 Infection in Hospitalized Individuals. PMID:34335605
Basic mechanisms of SARS-CoV-2 infection. What endocrine systems could be implicated? PMID:34333732
Bioinformatics Analysis of Expression Profiles and Prognostic Values of the Signal Transducer and Activator of Transcription Family Genes in Glioma. PMID:34276757
In vivo and in vitro human gene essentiality estimations capture contrasting functional constraints. PMID:34268495
Identification of Key Pathways and Genes in Obesity Using Bioinformatics Analysis and Molecular Docking Studies. PMID:34248836
ANANSE: an enhancer network-based computational approach for predicting key transcription factors in cell fate determination. PMID:34244796
Acupuncture Regulates Serum Differentially Expressed Proteins in Patients with Chronic Atrophic Gastritis: A Quantitative iTRAQ Proteomics Study. PMID:34234838
Single-cell nucleic acid profiling in droplets (SNAPD) enables high-throughput analysis of heterogeneous cell populations. PMID:34233007
Aberrant lung lipids cause respiratory impairment in a Mecp2-deficient mouse model of Rett syndrome. PMID:34230964
CODEX multiplexed tissue imaging with DNA-conjugated antibodies. PMID:34215862
Molecular Insights into the Oxygen-Sensing Pathway and Erythropoietin Expression Regulation in Erythropoiesis. PMID:34209205
A Comprehensive Bioinformatics Analysis of Notch Pathways in Bladder Cancer. PMID:34205690
Elucidating the Mechanism of Action of the Attributed Immunomodulatory Role of Eltrombopag in Primary Immune Thrombocytopenia: An In Silico Approach. PMID:34199099
Structural basis of the selective activation of enzyme isoforms: Allosteric response to activators of β1- and β2-containing AMPK complexes. PMID:34194666
A novel approach for studying receptor-ligand interactions on living cells surface by using NUS/T1ρ-NMR methodologies combined with computational techniques: The RGDechi15D-αvβ5 integrin complex. PMID:34188779
VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome. PMID:34183050
Repurposing of Anticancer Stem Cell Drugs in Brain Tumors. PMID:34165342
Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cells. PMID:34158609
Deoxyribonuclease 1-like 3 may be a potential prognostic biomarker associated with immune infiltration in colon cancer. PMID:34157681
Somatic mutation subtypes of lung adenocarcinoma in East Asian reveal divergent biological characteristics and therapeutic vulnerabilities. PMID:34142036
Expression and gene regulation network of TYMS and BCL2L1 in colorectal cancer based on data mining. PMID:34141464
Optimization of a modeling platform to predict oncogenes from genome-scale metabolic networks of non-small-cell lung cancers. PMID:34137202
A stable gene set for prediction of prognosis and efficacy of chemotherapy in gastric cancer. PMID:34112138
Machine learning-aided protein identification from multidimensional signatures. PMID:34109955
Highly Multiplexed Phenotyping of Immunoregulatory Proteins in the Tumor Microenvironment by CODEX Tissue Imaging. PMID:34093591
Exome sequencing reveals variants in known and novel candidate genes for severe sperm motility disorders. PMID:34089056
Genome Evolutionary Dynamics Meets Functional Genomics: A Case Story on the Identification of SLC25A44. PMID:34073512
Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response. PMID:34070078
To Ubiquitinate or Not to Ubiquitinate: TRIM17 in Cell Life and Death. PMID:34069831
New Approach for Untangling the Role of Uncommon Calcium-Binding Proteins in the Central Nervous System. PMID:34069107
Identification of an Altered Matrix Signature in Kidney Aging and Disease. PMID:34049963
Cytotoxicity and growth-inhibiting activity of Astragalus polysaccharides against breast cancer via the regulation of EGFR and ANXA1. PMID:34043154
CNVxplorer: a web tool to assist clinical interpretation of CNVs in rare disease patients. PMID:34019647
Turnover rate of coenzyme A in mouse brain and liver. PMID:34019583
Single cell RNA-seq analysis of the flexor digitorum brevis mouse myofibers. PMID:34001262
NT5DC2 promotes leiomyosarcoma tumour cell growth via stabilizing unpalmitoylated TEAD4 and generating a positive feedback loop. PMID:33993634
Novel compound heterozygous missense variants (c.G955A and c.A1822C) of CACNA2D4 likely causing autosomal recessive retinitis pigmentosa in a Chinese patient. PMID:33927996
The Marine Natural Product Furospinulosin 1 Induces Apoptosis in MDA-MB-231 Triple Negative Breast Cancer Cell Spheroids, But Not in Cells Grown Traditionally with Longer Treatment. PMID:33924764
Generation of a Polyclonal Antibody against the Mouse Metal Transporter ZIP8. PMID:33919173
Functional Roles of SPINK1 in Cancers. PMID:33916984
Balancing precision versus cohort transcriptomic analysis of acute and recovery phase of viral bronchiolitis. PMID:33851876
Chromatin Regulator SRG3 Overexpression Protects against LPS/D-GalN-Induced Sepsis by Increasing IL10-Producing Macrophages and Decreasing IFNγ-Producing NK Cells in the Liver. PMID:33809795
Emerging Role of ODC1 in Neurodevelopmental Disorders and Brain Development. PMID:33806076
Leptin Is Associated with Poor Clinical Outcomes and Promotes Clear Cell Renal Cell Carcinoma Progression. PMID:33804101
Leptin and Cancer: Updated Functional Roles in Carcinogenesis, Therapeutic Niches, and Developments. PMID:33799880
Analysis of human total antibody repertoires in TIF1γ autoantibody positive dermatomyositis. PMID:33772100
Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19. PMID:33767597
Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain. PMID:33742080
Multi-omics approaches for revealing the complexity of cardiovascular disease. PMID:33725119
N-cadherin upregulation mediates adaptive radioresistance in glioblastoma. PMID:33720050
Identification of hub genes in triple-negative breast cancer by integrated bioinformatics analysis. PMID:33708561
Discovery and validation of PZP as a novel serum biomarker for screening lung adenocarcinoma in type 2 diabetes mellitus patients. PMID:33691685
An Apoptotic Gene Signature for the Prognosis of Hepatocellular Carcinoma. PMID:33688206
MicroRNA-mRNA Networks in Pregnancy Complications: A Comprehensive Downstream Analysis of Potential Biomarkers. PMID:33669156
Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner. PMID:33640491
Analysis of Differentially Expressed Genes in the Dentate Gyrus and Anterior Cingulate Cortex in a Mouse Model of Depression. PMID:33628784
Spatiotemporal dissection of the cell cycle with single-cell proteogenomics. PMID:33627808
Evolution, structure and emerging roles of C1ORF112 in DNA replication, DNA damage responses, and cancer. PMID:33625522
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome. PMID:33579698
Omics Playground: a comprehensive self-service platform for visualization, analytics and exploration of Big Omics Data. PMID:33575569
Perinatal granulopoiesis and risk of pediatric asthma. PMID:33565964
Role of the HSP70 Co-Chaperone SIL1 in Health and Disease. PMID:33557244
The clinical significance of glutathione peroxidase 2 in glioblastoma multiforme. PMID:33552592
Functional lncRNA-miRNA-mRNA Networks in Response to Baicalein Treatment in Hepatocellular Carcinoma. PMID:33511213
Increased placental expression of angiotensin-converting enzyme 2, the receptor of SARS-CoV-2, associated with hypoxia in twin anemia-polycythemia sequence (TAPS). PMID:33497931
SARS-CoV-2 and other human coronaviruses: Mapping of protease recognition sites, antigenic variation of spike protein and their grouping through molecular phylogenetics. PMID:33497837
Endogenous Mobilization of Mesenchymal Stromal Cells: A Pathway for Interorgan Communication? PMID:33490065
The Prognostic Impact of Retinoid X Receptor and Thyroid Hormone Receptor alpha in Unifocal vs. Multifocal/Multicentric Breast Cancer. PMID:33478016
Increased expression of CELSR3 indicates a poor prognostic factor for Prostate Cancer. PMID:33442409
Interferon-inducible protein 16 may be a biomarker and prognostic factor in renal cell carcinoma by bioinformatics analysis. PMID:33429832
Exploring gene knockout strategies to identify potential drug targets using genome-scale metabolic models. PMID:33420254
Elucidating the network features and evolutionary attributes of intra- and interspecific protein-protein interactions between human and pathogenic bacteria. PMID:33420198
Circulating MicroRNAs in Relation to Esophageal Adenocarcinoma Diagnosis and Survival. PMID:33403483
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. PMID:33398198
Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure. PMID:33382739
The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells. PMID:33351855
Bioinformatics analysis identifies COL1A1, THBS2 and SPP1 as potential predictors of patient prognosis and immunotherapy response in gastric cancer. PMID:33345281
Tools for the Recognition of Sorting Signals and the Prediction of Subcellular Localization of Proteins From Their Amino Acid Sequences. PMID:33324450
Widespread Aberrant Alternative Splicing despite Molecular Remission in Chronic Myeloid Leukaemia Patients. PMID:33322625
Expression patterns and prognostic values of the cyclin-dependent kinase 1 and cyclin A2 gene cluster in pancreatic adenocarcinoma. PMID:33290118
Overexpression of TPX2 predicts poor clinical outcome and is associated with immune infiltration in hepatic cell cancer. PMID:33285774
Organic Cation Transporters in the Lung-Current and Emerging (Patho)Physiological and Pharmacological Concepts. PMID:33271927
Spatial Proteomic Approach to Characterize Skeletal Muscle Myofibers. PMID:33251806
Thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma. PMID:33240428
COVID-19 endocrinopathy with hindsight from SARS. PMID:33236920
Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-Mediated ARDS. PMID:33214479
Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota. PMID:33208821
Improving target assessment in biomedical research: the GOT-IT recommendations. PMID:33199880
DPPN-SVM: Computational Identification of Mis-Localized Proteins in Cancers by Integrating Differential Gene Expressions With Dynamic Protein-Protein Interaction Networks. PMID:33193746
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. PMID:33147445
The Human Protein Atlas-Spatial localization of the human proteome in health and disease. PMID:33146890
The Complexity and Dynamics of the Tissue Glycoproteome Associated With Prostate Cancer Progression. PMID:33127837
Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function. PMID:33122634
Identification of key genes and pathways for melanoma in the TRIM family. PMID:33118318
Developmental constraint shaped genome evolution and erythrocyte loss in Antarctic fishes following paleoclimate change. PMID:33108368
Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer. PMID:33099724
A high-stringency blueprint of the human proteome. PMID:33067450
Protein-protein and protein-nucleic acid binding residues important for common and rare sequence variants in human. PMID:33050876
Identification of immune checkpoint inhibitors and biomarkers among STAT family in stomach adenocarcinoma. PMID:33042401
The role of herpesvirus 6A and 6B in multiple sclerosis and epilepsy. PMID:33037649
Identification of PLOD Family Genes as Novel Prognostic Biomarkers for Hepatocellular Carcinoma. PMID:33014843
Comprehensive Analysis of the Expression, Relationship to Immune Infiltration and Prognosis of TIM-1 in Cancer. PMID:33014768
Integrative Analysis of Membrane Proteome and MicroRNA Reveals Novel Lung Cancer Metastasis Biomarkers. PMID:33005184
Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development. PMID:32999373
Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics. PMID:32993656
PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer. PMID:32985124
Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries. PMID:32973800
Spritz: A Proteogenomic Database Engine. PMID:32967423
Nutritional Therapy to Modulate Tryptophan Metabolism and Aryl Hydrocarbon-Receptor Signaling Activation in Human Diseases. PMID:32957545
A network pharmacology study on analgesic mechanism of Yuanhu-Baizhi herb pair. PMID:32948176
StoneMod: a database for kidney stone modulatory proteins with experimental evidence. PMID:32934277
Prospective evaluation of the lymph node proteome in dogs with multicentric lymphoma supplemented with sulforaphane. PMID:32926463
Pinpointing Cell Identity in Time and Space. PMID:32923457
Automated classification of protein subcellular localization in immunohistochemistry images to reveal biomarkers in colon cancer. PMID:32907537
SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation. PMID:32905556
Mining Database for the Expression and Clinical Significance of NF-κB Family in Hepatocellular Carcinoma. PMID:32879628
Advances in Astrocyte Computational Models: From Metabolic Reconstructions to Multi-omic Approaches. PMID:32848690
PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation. PMID:32819411
Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane. PMID:32788342
ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs. PMID:32780150
Sexually Dimorphic Crosstalk at the Maternal-Fetal Interface. PMID:32772088
SARS-CoV-2-host dynamics: Increased risk of adverse outcomes of COVID-19 in obesity. PMID:32755835
Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder. PMID:32744794
cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4. PMID:32733276
A Critical Review of Proteomic Studies in Gestational Diabetes Mellitus. PMID:32724825
(Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A. PMID:32718059
Effects of tesamorelin on hepatic transcriptomic signatures in HIV-associated NAFLD. PMID:32701508
Downregulation of LUZP2 Is Correlated with Poor Prognosis of Low-Grade Glioma. PMID:32695826
The prognostic value of leucine-rich repeat-containing G-protein (Lgr5) and its impact on clinicopathological features of colorectal cancer. PMID:32671503
Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells. PMID:32664515
Intellectual Disability and Potassium Channelopathies: A Systematic Review. PMID:32655623
Endocrine Significance of SARS-CoV-2's Reliance on ACE2. PMID:32652001
Serine Incorporator 2 (SERINC2) Expression Predicts an Unfavorable Prognosis of Low-Grade Glioma (LGG): Evidence from Bioinformatics Analysis. PMID:32642801
Clinical validation of the novel HDAC6 radiotracer [18F]EKZ-001 in the human brain. PMID:32638097
The transcriptional signature associated with human motile cilia. PMID:32616903
Analysis of Expression and Its Clinical Significance of the Secreted Phosphoprotein 1 in Lung Adenocarcinoma. PMID:32595698
ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance. PMID:32587767
Identification of an immune-related long non-coding RNA signature and nomogram as prognostic target for muscle-invasive bladder cancer. PMID:32579540
Regulation of cellular senescence by eukaryotic members of the FAH superfamily - A role in calcium homeostasis? PMID:32574647
Downregulation of CLCA4 expression is associated with the development and progression of colorectal cancer. PMID:32565987
A Sample Preparation Protocol for High Throughput Immunofluorescence of Suspension Cells on an Adherent Surface. PMID:32564662
Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor. PMID:32546533
Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS-CoV-2s. PMID:32529643
Immunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II. PMID:32499873
Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation. PMID:32482897
Personalized whole-body models integrate metabolism, physiology, and the gut microbiome. PMID:32463598
The Role of LIN28-let-7-ARID3B Pathway in Placental Development. PMID:32455665
Urinary proteomics links keratan sulfate degradation and lysosomal enzymes to early type 1 diabetes. PMID:32453760
Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks. PMID:32444848
Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract. PMID:32425701
Blood-derived biomarkers correlate with clinical progression in Duchenne muscular dystrophy. PMID:32390640
Promising diagnostic and prognostic value of six genes in human hepatocellular carcinoma. PMID:32355538
Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche. PMID:32354994
A genome wide association study for lung function in the Korean population using an exome array. PMID:32336055
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression. PMID:32326089
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer. PMID:32322170
Consistent RNA sequencing contamination in GTEx and other data sets. PMID:32321923
Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019? PMID:32314868
NCAPG Is a Promising Therapeutic Target Across Different Tumor Types. PMID:32300299
Gene Expression Profiles Identified Novel Urine Biomarkers for Diagnosis and Prognosis of High-Grade Bladder Urothelial Carcinoma. PMID:32292720
TGF-β1 secreted by pancreatic stellate cells promotes stemness and tumourigenicity in pancreatic cancer cells through L1CAM downregulation. PMID:32291413
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review. PMID:32265741
Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex. PMID:32235678
Peroxiredoxins and Immune Infiltrations in Colon Adenocarcinoma: Their Negative Correlations and Clinical Significances, an In Silico Analysis. PMID:32231717
OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine. PMID:32210335
An Integrated Meta-Analysis of Secretome and Proteome Identify Potential Biomarkers of Pancreatic Ductal Adenocarcinoma. PMID:32197468
FAM83A Promotes Lung Cancer Progression by Regulating the Wnt and Hippo Signaling Pathways and Indicates Poor Prognosis. PMID:32195172
Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. PMID:32193359
Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells. PMID:32170109
Fibroblast-specific genome-scale modelling predicts an imbalance in amino acid metabolism in Refsum disease. PMID:32160399
MicroRNA-361-Mediated Inhibition of HSP90 Expression and EMT in Cervical Cancer Is Counteracted by Oncogenic lncRNA NEAT1. PMID:32151082
Development of Potent Forchlorfenuron Analogs and Their Cytotoxic Effect in Cancer Cell Lines. PMID:32094384
Bioinformatics for Renal and Urinary Proteomics: Call for Aggrandization. PMID:32024005
A Unique Regulation Region in the 3' UTR of HLA-G with a Promising Potential. PMID:32019184
An Integrated Model Based on a Six-Gene Signature Predicts Overall Survival in Patients With Hepatocellular Carcinoma. PMID:32010188
A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population. PMID:31975031
Utility of primary cells to examine NPC1 receptor expression in Mops condylurus, a potential Ebola virus reservoir. PMID:31961874
Finding the Keys to the CAR: Identifying Novel Target Antigens for T Cell Redirection Immunotherapies. PMID:31947597
Polycystin 2 is increased in disease to protect against stress-induced cell death. PMID:31941974
Seminal fluid-mediated fitness effects in the simultaneously hermaphroditic flatworm Macrostomum lignano. PMID:31938489
Uncovering the Pharmacological Mechanism of Stemazole in the Treatment of Neurodegenerative Diseases Based on a Network Pharmacology Approach. PMID:31936558
DDX3X Multifunctionally Modulates Tumor Progression and Serves as a Prognostic Indicator to Predict Cancer Outcomes. PMID:31906196
Nuclear up regulation of the BRCA1-associated ubiquitinase BAP1 is associated with tumor aggressiveness in prostate cancers lacking the TMPRSS2:ERG fusion. PMID:31903168
Analysis of Differentially Expressed Genes in Coronary Artery Disease by Integrated Microarray Analysis. PMID:31881747
Genome-Scale Metabolic Modeling with Protein Expressions of Normal and Cancerous Colorectal Tissues for Oncogene Inference. PMID:31881674
An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity. PMID:31852821
Insulin Signaling as a Key Moderator in Myotonic Dystrophy Type 1. PMID:31849810
Relationship between Helicobacter pylori Infection and Plasmacytoid and Myeloid Dendritic Cells in Peripheral Blood and Gastric Mucosa of Children. PMID:31827378
Development of Immature CD4+CD8+T Cells Into Mature CD4+ T Cells Requires Alpha-1 Antitrypsin as Observed by Treatment in HIV-1 Infected and Uninfected Controls. PMID:31824943
Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD. PMID:31805375
HER2, NF-κB, and SATB1 Expression Patterns in Gastric Cancer and Their Correlation with Clinical and Pathological Parameters. PMID:31737131
Downregulation of HDGF inhibits the tumorigenesis of bladder cancer cells by inactivating the PI3K-AKT signaling pathway. PMID:31692549
Tissue-specific expression profiles and positive selection analysis in the tree swallow (Tachycineta bicolor) using a de novo transcriptome assembly. PMID:31676844
ProteomicsDB: a multi-omics and multi-organism resource for life science research. PMID:31665479
4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN. PMID:31660701
MIC_Locator: a novel image-based protein subcellular location multi-label prediction model based on multi-scale monogenic signal representation and intensity encoding strategy. PMID:31655541
Differentially Methylated Super-Enhancers Regulate Target Gene Expression in Human Cancer. PMID:31636280
Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells. PMID:31611601
In silico approach to calculate the transcript capacity. PMID:31610627
High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer. PMID:31606028
Genome-Scale Metabolic Modeling from Yeast to Human Cell Models of Complex Diseases: Latest Advances and Challenges. PMID:31602620
Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis. PMID:31602402
MicroRNA-424 regulates cisplatin resistance of gastric cancer by targeting SMURF1 based on GEO database and primary validation in human gastric cancer tissues. PMID:31571913
The CLN3 gene and protein: What we know. PMID:31568712
DHPS-dependent hypusination of eIF5A1/2 is necessary for TGFβ/fibronectin-induced breast cancer metastasis and associates with prognostically unfavorable genomic alterations in TP53. PMID:31558321
miR-205-5p inhibits human endometriosis progression by targeting ANGPT2 in endometrial stromal cells. PMID:31547870
Down-regulation and clinical significance of miR-7-2-3p in papillary thyroid carcinoma with multiple detecting methods. PMID:31538956
Enabling Web-scale data integration in biomedicine through Linked Open Data. PMID:31531395
Unsupervised machine learning using an imaging mass spectrometry dataset automatically reassembles grey and white matter. PMID:31519997
Aberrant Regulation of RAD51 Promotes Resistance of Neoadjuvant Endocrine Therapy in ER-positive Breast Cancer. PMID:31506496
HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. PMID:31500569
Downregulation of POFUT1 Impairs Secondary Myogenic Fusion Through a Reduced NFATc2/IL-4 Signaling Pathway. PMID:31500188
Breakdown of multiple sclerosis genetics to identify an integrated disease network and potential variant mechanisms. PMID:31482761
DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases. PMID:31467668
Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer. PMID:31467540
WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. PMID:31462314
Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy. PMID:31452838
Divide and conquer: two stem cell populations in squamous epithelia, reserves and the active duty forces. PMID:31451683
Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination. PMID:31437751
Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown. PMID:31434788
Inter-organ communication: a gatekeeper for metabolic health. PMID:31423716
Bringing Microscopy-By-Sequencing into View. PMID:31416630
Characterization of the prognostic values of the NDRG family in gastric cancer. PMID:31384305
Directed evolution as a tool for the selection of oncolytic RNA viruses with desired phenotypes. PMID:31372363
Decreased expression of SLC16A12 mRNA predicts poor prognosis of patients with clear cell renal cell carcinoma. PMID:31348313
The diagnostic and prognostic role of RhoA in hepatocellular carcinoma. PMID:31339860
Anticancer Immunotherapy by MFAP5 Blockade Inhibits Fibrosis and Enhances Chemosensitivity in Ovarian and Pancreatic Cancer. PMID:31332047
Structures of three ependymin-related proteins suggest their function as a hydrophobic molecule binder. PMID:31316816
Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes. PMID:31282863
Co-expression network analysis identified candidate biomarkers in association with progression and prognosis of breast cancer. PMID:31280346
In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes. PMID:31265809
A Circulating Tumor Cell-RNA Assay for Assessment of Androgen Receptor Signaling Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer. PMID:31244925
In silico Prediction of Human Secretory Proteins in Plasma Based on Discrete Firefly Optimization and Application to Cancer Biomarkers Identification. PMID:31244885
In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR. PMID:31244651
mTOR Signaling Pathway Regulates Sperm Quality in Older Men. PMID:31234465
MPZL1 promotes tumor cell proliferation and migration via activation of Src kinase in ovarian cancer. PMID:31233194
p73 regulates epidermal wound healing and induced keratinocyte programming. PMID:31216312
An expanded proteome of cardiac t-tubules. PMID:31202980
In Depth Quantification of Extracellular Matrix Proteins from Human Pancreas. PMID:31200599
Current status and applications of genome-scale metabolic models. PMID:31196170
A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation. PMID:31172184
pH and male fertility: making sense on pH homeodynamics throughout the male reproductive tract. PMID:31165202
Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics. PMID:31149033
Exploiting orthology and de novo transcriptome assembly to refine target sequence information. PMID:31122257
Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells. PMID:31068932
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease. PMID:31061469
The SUMO-Specific Protease Senp2 Regulates SUMOylation, Expression and Function of Human Organic Anion Transporter 3. PMID:31054272
SNW1 is a prognostic biomarker in prostate cancer. PMID:31043167
Expression of LAIR-1 (CD305) on Human Blood Monocytes as a Marker of Hepatic Cirrhosis Progression. PMID:31019980
YAP-independent mechanotransduction drives breast cancer progression. PMID:31015465
Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway. PMID:31001122
Crystal structure of human RIOK2 bound to a specific inhibitor. PMID:30991936
Overexpression of PARPBP Correlates with Tumor Progression and Poor Prognosis in Hepatocellular Carcinoma. PMID:30949905
Bioinformatics analysis of the prognostic value of CCT6A and associated signalling pathways in breast cancer. PMID:30942452
Multifactorial Contribution of Notch Signaling in Head and Neck Squamous Cell Carcinoma. PMID:30917608
Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis. PMID:30906868
Peroxiporins in Cancer. PMID:30893772
Respiratory dysfunction following initiation of mirabegron: A case report. PMID:30886821
Expression of zinc finger transcription factors (ZNF143 and ZNF281) in serous borderline ovarian tumors and low-grade ovarian cancers. PMID:30885238
Identification of Important Effector Proteins in the FOXJ1 Transcriptional Network Associated With Ciliogenesis and Ciliary Function. PMID:30881373
Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer. PMID:30875794
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy. PMID:30873179
GenTree, an integrated resource for analyzing the evolution and function of primate-specific coding genes. PMID:30862647
Increased LGALS3 expression independently predicts shorter overall survival in patients with the proneural subtype of glioblastoma. PMID:30848102
Evolutionary constraints on the complexity of genetic regulatory networks allow predictions of the total number of genetic interactions. PMID:30842463
Phosphorylation of a Conserved Tyrosine in the Papillomavirus E2 Protein Regulates Brd4 Binding and Viral Replication. PMID:30842331
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion. PMID:30836712
Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior. PMID:30814913
Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells. PMID:30810435
Pancreatic acinar differentiation is guided by differential laminin deposition. PMID:30804366
UBTD1 is a mechano-regulator controlling cancer aggressiveness. PMID:30804013
Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren's syndrome differ in molecular signatures and treatment perspectives. PMID:30777133
If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease. PMID:30775245
Overexpression of BUB1B, CCNA2, CDC20, and CDK1 in tumor tissues predicts poor survival in pancreatic ductal adenocarcinoma. PMID:30765611
Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG2M Phase. PMID:30759381
Programmable RNA detection with a fluorescent RNA aptamer using optimized three-way junction formation. PMID:30745364
CENPE expression is associated with its DNA methylation status in esophageal adenocarcinoma and independently predicts unfavorable overall survival. PMID:30716092
Spatial proteomics: a powerful discovery tool for cell biology. PMID:30659282
Expression and clinical significance of basic transcription factor 3 in nasopharyngeal carcinoma. PMID:30655831
A model to predict the function of hypothetical proteins through a nine-point classification scoring schema. PMID:30621574
A region-resolved mucosa proteome of the human stomach. PMID:30604760
Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus. PMID:30591584
Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner. PMID:30567987
A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase. PMID:30563079
Integrin Subunit beta 8 (ITGB8) Upregulation Is an Independent Predictor of Unfavorable Survival of High-Grade Serous Ovarian Carcinoma Patients. PMID:30531684
Stable-protein Pair Analysis as A Novel Strategy to Identify Proteomic Signatures: Application To Seminal Plasma From Infertile Patients. PMID:30518674
Integrated Identification and Quantification Error Probabilities for Shotgun Proteomics. PMID:30482846
TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression. PMID:30479348
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. PMID:30476243
Assembly of a parts list of the human mitotic cell cycle machinery. PMID:30452682
miRNA Mediated Noise Making of 3'UTR Mutations in Cancer. PMID:30424545
Cancer-Associated Function of 2-Cys Peroxiredoxin Subtypes as a Survival Gatekeeper. PMID:30423872
Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma. PMID:30419838
Exploring Seipin: From Biochemistry to Bioinformatics Predictions. PMID:30402103
HAVCR1 expression might be a novel prognostic factor for gastric cancer. PMID:30388143
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro. PMID:30387835
Effect of equiaxial cyclic strain on cardiomyogenic induction in mesenchymal stem cells. PMID:30367393
Salvianolic acid A targeting the transgelin-actin complex to enhance vasoconstriction. PMID:30361065
Targeted Analysis of Serum Proteins Encoded at Known Inflammatory Bowel Disease Risk Loci. PMID:30358838
Druggability of Coronary Artery Disease Risk Loci. PMID:30354342
Genetic expression profile-based screening of genes and pathways associated with papillary thyroid carcinoma. PMID:30344727
Impact of chemotactic factors and receptors on the cancer immune infiltrate: a bioinformatics study revealing homogeneity and heterogeneity among patient cohorts. PMID:30288345
Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes. PMID:30250408
Associations of sirtuins with clinicopathological parameters and prognosis in non-small cell lung cancer. PMID:30237737
Drug Repurposing of Metabolic Agents in Malignant Glioma. PMID:30223473
Identification of Key Pathways and Genes in Anaplastic Thyroid Carcinoma via Integrated Bioinformatics Analysis. PMID:30213925
Protein fishing from single live cells. PMID:30205820
A Computational Method for Classifying Different Human Tissues with Quantitatively Tissue-Specific Expressed Genes. PMID:30205473
In vitro evaluation of dual-antigenic PV1 peptide vaccine in head and neck cancer patients. PMID:30193086
Hypoxia-inducible transgelin 2 selects epithelial-to-mesenchymal transition and γ-radiation-resistant subtypes by focal adhesion kinase-associated insulin-like growth factor 1 receptor activation in non-small-cell lung cancer cells. PMID:30191639
Cross-tissue eQTL enrichment of associations in schizophrenia. PMID:30188921
Meta-analysis of exome array data identifies six novel genetic loci for lung function. PMID:30175238
Deep learning is combined with massive-scale citizen science to improve large-scale image classification. PMID:30125267
Molecular Approaches to Safe and Controlled Engineered T-cell Therapy. PMID:30116611
Identification of pathways and genes associated with cerebral palsy. PMID:30109564
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms. PMID:30101371
KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control. PMID:30061100
Toward mapping the human body at a cellular resolution. PMID:30058989
Characterization of FGD5 Expression in Primary Breast Cancers and Lymph Node Metastases. PMID:30052477
Microarray gene expression profiling in colorectal (HCT116) and hepatocellular (HepG2) carcinoma cell lines treated with Melicope ptelefolia leaf extract reveals transcriptome profiles exhibiting anticancer activity. PMID:30042885
Global Interactomics Uncovers Extensive Organellar Targeting by Zika Virus. PMID:30037810
Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer. PMID:29975776
Expression of 4E-BP1 and phospho-4E-BP1 correlates with the prognosis of patients with clear cell renal carcinoma. PMID:29942157
Papillomavirus E2 protein is regulated by specific fibroblast growth factor receptors. PMID:29885490
Fibroblasts in the Tumor Microenvironment: Shield or Spear? PMID:29883428
Understanding the seminal plasma proteome and its role in male fertility. PMID:29881623
Upregulation of KIF26B, Cell Migration and Proliferation of Human Ovarian Cancer Cell Lines In Vitro, and Patient Outcomes from Human Bioinformatic Analysis. PMID:29880787
Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions-benign adenomas and inflammatory bowel disease. PMID:29875879
Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models. PMID:29856687
Increased GOLM1 Expression Independently Predicts Unfavorable Overall Survival and Recurrence-Free Survival in Lung Adenocarcinoma. PMID:29843532
Proteomic and bioinformatic discovery of biomarkers for diabetic nephropathy. PMID:29805343
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology. PMID:29784938
Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease. PMID:29782846
CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. PMID:29763414
Aberrant S100A16 expression might be an independent prognostic indicator of unfavorable survival in non-small cell lung adenocarcinoma. PMID:29746588
Transcellular transport of cobalamin in aortic endothelial cells. PMID:29741927
Comparative Analysis of Human Genes Frequently and Occasionally Regulated by m6A Modification. PMID:29730206
Genome sequencing in the clinic: the past, present, and future of genomic medicine. PMID:29727589
Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer. PMID:29723302
A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. PMID:29719227
Profiling plasma extracellular vesicle by pluronic block-copolymer based enrichment method unveils features associated with breast cancer aggression, metastasis and invasion. PMID:29696079
Integrated bioinformatics analysis reveals key candidate genes and pathways in breast cancer. PMID:29693125
Cross-species inference of long non-coding RNAs greatly expands the ruminant transcriptome. PMID:29690875
Cardiomyocytes have mosaic patterns of protein expression. PMID:29677652
CTGF/VEGFA-activated Fibroblasts Promote Tumor Migration Through Micro-environmental Modulation. PMID:29669735
[Value of CHCHD2 as a potential marker of non-small cell lung cancer: analysis of 60 cases]. PMID:29643040
A Protein Standard That Emulates Homology for the Characterization of Protein Inference Algorithms. PMID:29631402
TISSUES 2.0: an integrative web resource on mammalian tissue expression. PMID:29617745
Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancer. PMID:29568088
Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions. PMID:29514827
Streptococcus pyogenes Infection and the Human Proteome with a Special Focus on the Immunoglobulin G-cleaving Enzyme IdeS. PMID:29511047
CDCA5 regulates proliferation in hepatocellular carcinoma and has potential as a negative prognostic marker. PMID:29503564
Carbonic Anhydrases: Role in pH Control and Cancer. PMID:29495652
The Gene-Centric Content Management System and Its Application for Cognitive Proteomics. PMID:29473895
CGB5 expression is independently associated with poor overall survival and recurrence-free survival in patients with advanced gastric cancer. PMID:29473345
A cell death assay for assessing the mitochondrial targeting of proteins. PMID:29454998
Tumor microenvironment heterogeneity: challenges and opportunities. PMID:29430386
Peptide Level Turnover Measurements Enable the Study of Proteoform Dynamics. PMID:29414762
Ascending the PEAK1 toward targeting TGFβ during cancer progression: Recent advances and future perspectives. PMID:29392163
Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer. PMID:29382334
Fragility Extraordinaire: Unsolved Mysteries of Chromosome Fragile Sites. PMID:29357071
Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody. PMID:29356983
Dynamic changes in copper homeostasis and post-transcriptional regulation of Atp7a during myogenic differentiation. PMID:29333545
Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells. PMID:29297499
ASAP3 regulates microvilli structure in parietal cells and presents intervention target for gastric acidity. PMID:29263912
Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective. PMID:29258237
Biotinylation by antibody recognition-a method for proximity labeling. PMID:29256494
Rho GDP dissociation inhibitor-β in renal cell carcinoma. PMID:29250194
Transcription and Remodeling Produce Asymmetrically Unwrapped Nucleosomal Intermediates. PMID:29225036
Annotating gene sets by mining large literature collections with protein networks. PMID:29218918
Neovascular Prostate-Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma. PMID:29209626
Diagnostic significance and potential function of miR-338-5p in hepatocellular carcinoma: A bioinformatics study with microarray and RNA sequencing data. PMID:29207053
Identification of hub miRNA biomarkers for bladder cancer by weighted gene coexpression network analysis. PMID:29200870
Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling. PMID:29187877
Tumoral ANXA1 Is a Predictive Marker for Sunitinib Treatment of Renal Cancer Patients. PMID:29187872
Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations. PMID:29162437
LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness. PMID:29137369
Prognostic microRNAs and their potential molecular mechanism in pancreatic cancer: A study based on The Cancer Genome Atlas and bioinformatics investigation. PMID:29115476
NLSdb-major update for database of nuclear localization signals and nuclear export signals. PMID:29106588
High SLC4A11 expression is an independent predictor for poor overall survival in grade 3/4 serous ovarian cancer. PMID:29091960
TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules. PMID:29088312
Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP). PMID:29059175
CR2Cancer: a database for chromatin regulators in human cancer. PMID:29036683
The SysteMHC Atlas project. PMID:28985418
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. PMID:28977666
Nuclear speckles: molecular organization, biological function and role in disease. PMID:28977640
IMOTA: an interactive multi-omics tissue atlas for the analysis of human miRNA-target interactions. PMID:28977416
Kinase-templated abiotic reaction. PMID:28970898
Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis. PMID:28962592
The human protein atlas: A spatial map of the human proteome. PMID:28940711
In situ protein detection with enhanced specificity using DNA-conjugated antibodies and proximity ligation. PMID:28937142
CellNetVis: a web tool for visualization of biological networks using force-directed layout constrained by cellular components. PMID:28929969
Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling. PMID:28925397
The SubCons webserver: A user friendly web interface for state-of-the-art subcellular localization prediction. PMID:28901589
Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in Trypanosoma brucei. PMID:28887303
Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. PMID:28878041
ITGA1 is a pre-malignant biomarker that promotes therapy resistance and metastatic potential in pancreatic cancer. PMID:28855593
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. PMID:28812582
Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth. PMID:28794006
Kinase Activity of Fibroblast Growth Factor Receptor 3 Regulates Activity of the Papillomavirus E2 Protein. PMID:28768864
Interleukin-17C in Human Helicobacter pylori Gastritis. PMID:28739826
Combined deletion and DNA methylation result in silencing of FAM107A gene in laryngeal tumors. PMID:28710449
Crosstalk and the evolvability of intracellular communication. PMID:28691706
Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway. PMID:28674149
Downregulation of adaptor protein MyD88 compromises the angiogenic potential of B16 murine melanoma. PMID:28662055
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. PMID:28659575
Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity. PMID:28625833
Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines. PMID:28621943
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. PMID:28530674
GeMSTONE: orchestrated prioritization of human germline mutations in the cloud. PMID:28521008
Pro-necrotic molecules impact local immunosurveillance in human breast cancer. PMID:28507808
Serological Epithelial Component Proteins Identify Intestinal Complications in Crohn's Disease. PMID:28490445
Multi-omics approaches to disease. PMID:28476144
Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma. PMID:28445125
Social Behavior of Pet Dogs Is Associated with Peripheral OXTR Methylation. PMID:28443051
Quantitative diagnosis of breast tumors by morphometric classification of microenvironmental myoepithelial cells using a machine learning approach. PMID:28440283
B Cell Tolerance to Deiminated Histones in BALB/c, C57BL/6, and Autoimmune-Prone Mouse Strains. PMID:28424695
Tetraspanin 8 (TSPAN 8) as a potential target for radio-immunotherapy of colorectal cancer. PMID:28423546
Machine learning in computational biology to accelerate high-throughput protein expression. PMID:28398465
High-confidence coding and noncoding transcriptome maps. PMID:28396519
Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein Interactions. PMID:28385878
Expression and clinical value of EGFR in human meningiomas. PMID:28367377
Eosinophilic Esophagitis: A Primary Disease of the Esophageal Mucosa. PMID:28363400
ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. PMID:28351972
A quantitative method for screening and identifying molecular targets for nanomedicine. PMID:28341549
Genotype-based gene signature of glioma risk. PMID:28339748
A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis. PMID:28330499
Extracellular Proton Concentrations Impacts LN229 Glioblastoma Tumor Cell Fate via Differential Modulation of Surface Lipids. PMID:28299282
Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer. PMID:28290516
Discovery of circulating proteins associated to knee radiographic osteoarthritis. PMID:28273936
Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway. PMID:28258213
Use of Aleuria alantia Lectin Affinity Chromatography to Enrich Candidate Biomarkers from the Urine of Patients with Bladder Cancer. PMID:28248271
"Omics"-Informed Drug and Biomarker Discovery: Opportunities, Challenges and Future Perspectives. PMID:28248238
Transcriptomic comparison of primary bovine horn core carcinoma culture and parental tissue at early stage. PMID:28246447
A method for characterizing phenotypic changes in highly variable cell populations and its application to high content screening of Arabidopsis thaliana protoplasts. PMID:28245335
A concept for holistic whole body MRI data analysis, Imiomics. PMID:28241015
Human Nup98 regulates the localization and activity of DExH/D-box helicase DHX9. PMID:28221134
ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms? PMID:28220105
A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels. PMID:28194012
Evaluation of [18F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer. PMID:28157626
Identifying the missing proteins in human proteome by biological language model. PMID:28155671
Correlated 5-Hydroxymethylcytosine (5hmC) and Gene Expression Profiles Underpin Gene and Organ-Specific Epigenetic Regulation in Adult Mouse Brain and Liver. PMID:28125731
The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis. PMID:28114279
Peroxiporin Expression Is an Important Factor for Cancer Cell Susceptibility to Therapeutic H2O2: Implications for Pharmacological Ascorbate Therapy. PMID:28107421
Lysozyme association with circulating RNA, extracellular vesicles, and chronic stress. PMID:28053879
Mutations in BOREALIN cause thyroid dysgenesis. PMID:28025328
MetaboSignal: a network-based approach for topological analysis of metabotype regulation via metabolic and signaling pathways. PMID:28011775
New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells. PMID:28009074
Recon2Neo4j: applying graph database technologies for managing comprehensive genome-scale networks. PMID:27993779
Characterization of glomerular extracellular matrix by proteomic analysis of laser-captured microdissected glomeruli. PMID:27988214
Salivary and pellicle proteome: A datamining analysis. PMID:27966577
Functional Analyses of the Crohn's Disease Risk Gene LACC1. PMID:27959965
An Optimized Chromatographic Strategy for Multiplexing In Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases. PMID:27940637
Three-Dimensionally Functionalized Reverse Phase Glycoprotein Array for Cancer Biomarker Discovery and Validation. PMID:27933927
In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. PMID:27927684
Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome. PMID:27923875
Maximising the potential of AKT inhibitors as anti-cancer treatments. PMID:27919797
Hepatocarcinogenesis in transgenic mice carrying hepatitis B virus pre-S/S gene with the sW172* mutation. PMID:27918551
Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up. PMID:27901618
The neXtProt knowledgebase on human proteins: 2017 update. PMID:27899619
Physiologically-based modeling to predict the clinical behavior of monoclonal antibodies directed against lymphocyte antigens. PMID:27892793
SNAP23 promotes the malignant process of ovarian cancer. PMID:27855700
Quantitative GTPase Affinity Purification Identifies Rho Family Protein Interaction Partners. PMID:27852748
Expression Data Analysis for the Identification of Potential Biomarker of Pregnancy Associated Breast Cancer. PMID:27832451
In Silico Analysis Validates Proteomic Findings of Formalin-fixed Paraffin Embedded Cutaneous Squamous Cell Carcinoma Tissue. PMID:27807068
Molecular mechanisms underlying COPD-muscle dysfunction unveiled through a systems medicine approach. PMID:27794560
Identification of internalin-A-like virulent proteins in Leishmania donovani. PMID:27765050
Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma. PMID:27764136
Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer. PMID:27723779
Proteomic Analysis of Non-depleted Serum Proteins from Bottlenose Dolphins Uncovers a High Vanin-1 Phenotype. PMID:27667588
Using reverse-phase protein arrays as pharmacodynamic assays for functional proteomics, biomarker discovery, and drug development in cancer. PMID:27663479
Genomic characterization of liver metastases from colorectal cancer patients. PMID:27662660
PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide. PMID:27661404
Mitochondrial CHCHD-Containing Proteins: Physiologic Functions and Link with Neurodegenerative Diseases. PMID:27631878
Study of apoptosis-related interactions in colorectal cancer. PMID:27629291
Long-term outcome in young women with breast cancer: a population-based study. PMID:27624330
Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study. PMID:27594614
Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma. PMID:27588472
Complex Sources of Variation in Tissue Expression Data: Analysis of the GTEx Lung Transcriptome. PMID:27588449
Decreased expression of stomatin predicts poor prognosis in HER2-positive breast cancer. PMID:27577936
Mapping the Cell-Surface N-Glycoproteome of Human Hepatocytes Reveals Markers for Selecting a Homogeneous Population of iPSC-Derived Hepatocytes. PMID:27569060
Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment. PMID:27558259
Exaptation of Bornavirus-Like Nucleoprotein Elements in Afrotherians. PMID:27518265
Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin. PMID:27484226
Association of TGFβ signaling with the maintenance of a quiescent stem cell niche in human oral mucosa. PMID:27480259
Truncating Mutations in the Adhesion G Protein-Coupled Receptor G2 Gene ADGRG2 Cause an X-Linked Congenital Bilateral Absence of Vas Deferens. PMID:27476656
Integrative Analysis of Microarray Data to Reveal Regulation Patterns in the Pathogenesis of Hepatocellular Carcinoma. PMID:27458175
Computational studies of human class V alcohol dehydrogenase - the odd sibling. PMID:27455956
Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues. PMID:27454740
Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study. PMID:27421136
Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks. PMID:27403431
H11/HSPB8 Restricts HIV-2 Vpx to Restore the Anti-Viral Activity of SAMHD1. PMID:27379031
Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies. PMID:27377311
Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer. PMID:27371729
Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. PMID:27367781
Extent of pre-translational regulation for the control of nucleocytoplasmic protein localization. PMID:27342569
Identification of key genes in glioblastoma-associated stromal cells using bioinformatics analysis. PMID:27313730
Fbw7 and Usp28 - enemies and allies. PMID:27308481
The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression. PMID:27273514
Sox9 overexpression in uterine epithelia induces endometrial gland hyperplasia. PMID:27262401
Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow. PMID:27250503
A pilot study using dynamic contrast enhanced-MRI as a response biomarker of the radioprotective effect of memantine in patients receiving whole brain radiotherapy. PMID:27248467
Paracellular epithelial sodium transport maximizes energy efficiency in the kidney. PMID:27214555
Phenotyping of Leukocytes and Leukocyte-Derived Extracellular Vesicles. PMID:27195303
The calmodulin-binding transcription activator CAMTA1 is required for long-term memory formation in mice. PMID:27194798
Intrahepatic and extrahepatic aminotransferase elevation associated with clinical-therapeutic events in a schizophrenic patient. PMID:27190609
Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis. PMID:27183383
Learning from Heterogeneous Data Sources: An Application in Spatial Proteomics. PMID:27175778
EGFR Activation Leads to Cell Death Independent of PI3K/AKT/mTOR in an AD293 Cell Line. PMID:27153109
Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes. PMID:27152864
BMP2/BMPR1A is linked to tumour progression in dedifferentiated liposarcomas. PMID:27114889
Free and complexed-secretory immunoglobulin A triggers distinct intestinal epithelial cell responses. PMID:27084834
Mouse Sox17 haploinsufficiency leads to female subfertility due to impaired implantation. PMID:27053385
Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas. PMID:27051068
Profiling lethal factor interacting proteins from human stomach using T7 phage display screening. PMID:27035230
The biology of DHX9 and its potential as a therapeutic target. PMID:27034008
A Systematic Characterization of Aquaporin-9 Expression in Human Normal and Pathological Tissues. PMID:27026296
Utilization of HPASubC for the Identification of Sinusoid-Specific Proteins in the Liver. PMID:27005832
Nuclear Localization of the Autism Candidate Gene Neurobeachin and Functional Interaction with the NOTCH1 Intracellular Domain Indicate a Role in Regulating Transcription. PMID:26999814
Integrin signalling regulates YAP and TAZ to control skin homeostasis. PMID:26989177
Heterochromatin Protein 1 Binding Protein 3 Expression as a Candidate Marker of Intrinsic 5-Fluorouracil Resistance. PMID:26976970
In silico and experimental analyses predict the therapeutic value of an EZH2 inhibitor GSK343 against hepatocellular carcinoma through the induction of metallothionein genes. PMID:26973856
Survival kinase genes present prognostic significance in glioblastoma. PMID:26956052
A Human "eFP" Browser for Generating Gene Expression Anatograms. PMID:26954504
Proteomic profiling identifies the inorganic pyrophosphatase (PPA1) protein as a potential biomarker of metastasis in laryngeal squamous cell carcinoma. PMID:26948660
APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis. PMID:26942872
Reconstruction of Tissue-Specific Metabolic Networks Using CORDA. PMID:26942765
Galectin signatures contribute to the heterogeneity of breast cancer and provide new prognostic information and therapeutic targets. PMID:26933916
Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. PMID:26917578
Evaluation of serum and tissue levels of VAP-1 in colorectal cancer. PMID:26912327
Recurrent CDK1 overexpression in laryngeal squamous cell carcinoma. PMID:26912061
The UniProtKB guide to the human proteome. PMID:26896845
Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant. PMID:26885373
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma. PMID:26855150
The contribution of Alu exons to the human proteome. PMID:26821878
Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo. PMID:26821263
CP-CHARM: segmentation-free image classification made accessible. PMID:26817459
PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis. PMID:26784545
A robust nonlinear tissue-component discrimination method for computational pathology. PMID:26779829
AURA 2: Empowering discovery of post-transcriptional networks. PMID:26779400
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer. PMID:26771841
ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression. PMID:26771237
A draft map of the mouse pluripotent stem cell spatial proteome. PMID:26754106
SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. PMID:26739564
ICAM-1-Targeted, Lcn2 siRNA-Encapsulating Liposomes are Potent Anti-angiogenic Agents for Triple Negative Breast Cancer. PMID:26722369
Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker. PMID:26719704
Phthalate metabolism and kinetics in an in vitro model of testis development. PMID:26689326
ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation. PMID:26680585
Systems Proteomics View of the Endogenous Human Claudin Protein Family. PMID:26680015
Pharmacological Inhibition of O-GlcNAcase Does Not Increase Sensitivity of Glucocorticoid Receptor-Mediated Transrepression. PMID:26670328
Antiviral innate immunity through the lens of systems biology. PMID:26657882
Two Forkhead transcription factors regulate cardiac progenitor specification by controlling the expression of receptors of the fibroblast growth factor and Wnt signaling pathways. PMID:26657774
Phospholipase C-β1 Hypofunction in the Pathogenesis of Schizophrenia. PMID:26635636
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. PMID:26635082
Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants. PMID:26633466
Expression of ALDH1A1 and CD44 in primary head and neck squamous cell carcinoma and their value for carcinogenesis, tumor progression and cancer stem cell identification. PMID:26622836
Phospholipase C Beta 1: a Candidate Signature Gene for Proneural Subtype High-Grade Glioma. PMID:26614510
Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility. PMID:26610392
Genome-Wide Association Study of Golden Retrievers Identifies Germ-Line Risk Factors Predisposing to Mast Cell Tumours. PMID:26588071
Evaluating Serum Markers for Hormone Receptor-Negative Breast Cancer. PMID:26565788
GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles. PMID:26514725
Neural Stem Cells (NSCs) and Proteomics. PMID:26494823
The gut microbiota modulates host amino acid and glutathione metabolism in mice. PMID:26475342
Recent advances in the pathological understanding of eosinophilic esophagitis. PMID:26470602
Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality. PMID:26451775
A proteomic glimpse into human ureter proteome. PMID:26442468
The Nuclear Proteome of a Vertebrate. PMID:26441354
Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins. PMID:26437229
Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue. PMID:26434764
New genes drive the evolution of gene interaction networks in the human and mouse genomes. PMID:26424194
Identification of Circulating Biomarker Candidates for Hepatocellular Carcinoma (HCC): An Integrated Prioritization Approach. PMID:26414287
PUBLIC HEALTH AND EPIDEMIOLOGICAL DATABASES FOR THE ENHANCEMENT OF MEDICAL EDUCATION. PMID:26392847
The expression and post-transcriptional regulation of FSTL1 transcripts in placental trophoblasts. PMID:26386648
Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity. PMID:26378251
Role of insulin-like growth factor-binding proteins in the pathophysiology and tumorigenesis of gastroesophageal cancers. PMID:26369544
The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity. PMID:26358779
Panorama of ancient metazoan macromolecular complexes. PMID:26344197
Prediction and validation of enzyme and transporter off-targets for metformin. PMID:26335661
Network Topologies Decoding Cervical Cancer. PMID:26308848
Identification of a PEAK1/ZEB1 signaling axis during TGFβ/fibronectin-induced EMT in breast cancer. PMID:26297948
A High Through-put Platform for Recombinant Antibodies to Folded Proteins. PMID:26290498
Identifying new targets in leukemogenesis using computational approaches. PMID:26288567
LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2. PMID:26288135
TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma. PMID:26276037
Extensive shift in placental transcriptome profile in preeclampsia and placental origin of adverse pregnancy outcomes. PMID:26268791
PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer. PMID:26267863
From genetics to treatment of eosinophilic esophagitis. PMID:26258919
Exosomes in the Thymus: Antigen Transfer and Vesicles. PMID:26257734
E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade. PMID:26246502
Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer. PMID:26237329
Human metabolic atlas: an online resource for human metabolism. PMID:26209309
Whole exome sequencing in extended families with autism spectrum disorder implicates four candidate genes. PMID:26204995
Structural Bioinformatics Inspection of neXtProt PE5 Proteins in the Human Proteome. PMID:26193931
Reverse phase protein arrays in signaling pathways: a data integration perspective. PMID:26185419
HPASubC: A suite of tools for user subclassification of human protein atlas tissue images. PMID:26167380
PAX5-KIAA1549L: a novel fusion gene in a case of pediatric B-cell precursor acute lymphoblastic leukemia. PMID:26157485
Evaluation of retinol binding protein 4 and carbamoylated haemoglobin as potential renal toxicity biomarkers in adult mice treated with (177)Lu-octreotate. PMID:26116120
Rechecking the Centrality-Lethality Rule in the Scope of Protein Subcellular Localization Interaction Networks. PMID:26115027
Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay. PMID:26114578
The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling. PMID:26109061
Gene expression analysis of skin grafts and cultured keratinocytes using synthetic RNA normalization reveals insights into differentiation and growth control. PMID:26108968
Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma. PMID:26106611
Linking patient outcome to high throughput protein expression data identifies novel regulators of colorectal adenocarcinoma aggressiveness. PMID:26097693
Examination of Epigenetic and other Molecular Factors Associated with mda-9/Syntenin Dysregulation in Cancer Through Integrated Analyses of Public Genomic Datasets. PMID:26093898
HCSD: the human cancer secretome database. PMID:26078477
FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development. PMID:26061565
Identification and characterization of the gene expression profiles for protein coding and non-coding RNAs of pancreatic ductal adenocarcinomas. PMID:26053098
A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. PMID:26030696
High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy. PMID:26026368
SPECTRA: An Integrated Knowledge Base for Comparing Tissue and Tumor-Specific PPI Networks in Human. PMID:26005672
Decorin in Human Colon Cancer: Localization In Vivo and Effect on Cancer Cell Behavior In Vitro. PMID:26001829
UPF0586 Protein C9orf41 Homolog Is Anserine-producing Methyltransferase. PMID:26001783
Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for Cancer Chemoprevention. PMID:26000234
Multidimensional gene search with Genehopper. PMID:25990726
Direct inhibition of retinoic acid catabolism by fluoxetine. PMID:25981674
A repository of assays to quantify 10,000 human proteins by SWATH-MS. PMID:25977788
Prediction of intracellular metabolic states from extracellular metabolomic data. PMID:25972769
Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics. PMID:25970776
ADME SARfari: comparative genomics of drug metabolizing systems. PMID:25964657
A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer. PMID:25948588
Transcriptome profiling identifies p53 as a key player during calreticulin deficiency: Implications in lipid accumulation. PMID:25946468
Understanding multicellular function and disease with human tissue-specific networks. PMID:25915600
BST2/tetherin inhibition of alphavirus exit. PMID:25912717
Vitamin D Receptor Polymorphisms Are Associated with Reduced Esophageal Vitamin D Receptor Expression and Reduced Esophageal Adenocarcinoma Risk. PMID:25910066
Protein microarrays: a new tool for the study of autoantibodies in immunodeficiency. PMID:25904912
Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis. PMID:25902861
Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer. PMID:25898255
Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation. PMID:25895698
Psoriatic arthritis under a proteomic spotlight: application of novel technologies to advance diagnosis and management. PMID:25895652
A mass spectrometric-derived cell surface protein atlas. PMID:25894527
Influence of SNP*SNP interaction on BMI in European American adolescents: findings from the National Longitudinal Study of Adolescent Health. PMID:25893265
The proteomic landscape of triple-negative breast cancer. PMID:25892236
Systems medicine: evolution of systems biology from bench to bedside. PMID:25891169
Multidimensional proteomics for cell biology. PMID:25857810
Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy. PMID:25837326
The MS4A family: counting past 1, 2 and 3. PMID:25835430
Human gastroenteropancreatic expression of melatonin and its receptors MT1 and MT2. PMID:25822611
Dissecting antibodies with regards to linear and conformational epitopes. PMID:25816293
Modelling the effect of SPION size in a stent assisted magnetic drug targeting system with interparticle interactions. PMID:25815370
Immunocapture-Selected Reaction Monitoring Screening Facilitates the Development of ELISA for the Measurement of Native TEX101 in Biological Fluids. PMID:25813379
The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes. PMID:25799151
Arginine depletion by arginine deiminase does not affect whole protein metabolism or muscle fractional protein synthesis rate in mice. PMID:25775142
IGF-Binding Protein 2 - Oncogene or Tumor Suppressor? PMID:25774149
In‑depth mapping of human testicular and epididymal proteins and their functional association with spermatozoa. PMID:25760095
Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters. PMID:25759379
A Grhl2-dependent gene network controls trophoblast branching morphogenesis. PMID:25758223
Protein shedding in urothelial bladder cancer: prognostic implications of soluble urinary EGFR and EpCAM. PMID:25719831
An active role for basement membrane assembly and modification in tissue sculpting. PMID:25717004
miR-27b synergizes with anticancer drugs via p53 activation and CYP1B1 suppression. PMID:25698578
An integrative approach for a network based meta-analysis of viral RNAi screens. PMID:25691914
Visualization of proteomics data using R and bioconductor. PMID:25690415
Affinity proteomics discovers decreased levels of AMFR in plasma from Osteoporosis patients. PMID:25689831
Large scale aggregate microarray analysis reveals three distinct molecular subclasses of human preeclampsia. PMID:25679511
Luzp4 defines a new mRNA export pathway in cancer cells. PMID:25662211
Overexpression of IFN-induced protein with tetratricopeptide repeats 3 (IFIT3) in pancreatic cancer: cellular "pseudoinflammation" contributing to an aggressive phenotype. PMID:25650658
Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1. PMID:25648650
Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis. PMID:25647640
Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling. PMID:25640694
Liver enzymes, metabolomics and genome-wide association studies: from systems biology to the personalized medicine. PMID:25624707
Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel encoded by KCNJ6. PMID:25620207
Evolutionary constraint and disease associations of post-translational modification sites in human genomes. PMID:25611800
C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization. PMID:25605331
Recurrent ZFX mutations in human sporadic parathyroid adenomas. PMID:25594030
SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types. PMID:25594027
The neXtProt knowledgebase on human proteins: current status. PMID:25593349
Amyloid precursor protein interaction network in human testis: sentinel proteins for male reproduction. PMID:25591988
Breast cancer genes PSMC3IP and EPSTI1 play a role in apoptosis regulation. PMID:25590583
Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2. PMID:25580517
Down-regulation of TIMP-1 inhibits cell migration, invasion, and metastatic colonization in lung adenocarcinoma. PMID:25578494
Genome-scale modeling for metabolic engineering. PMID:25578304
Rubella. PMID:25576992
DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance. PMID:25575823
p-CREB expression in human meningiomas: correlation with angiogenesis and recurrence risk. PMID:25563814
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. PMID:25561175
The kidney transcriptome and proteome defined by transcriptomics and antibody-based profiling. PMID:25551756
Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas. PMID:25551685
The human pancreas proteome defined by transcriptomics and antibody-based profiling. PMID:25546435
The transcriptomic and proteomic landscapes of bone marrow and secondary lymphoid tissues. PMID:25541736
An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma. PMID:25535366
Recombinant renewable polyclonal antibodies. PMID:25530082
Tumor antigens as proteogenomic biomarkers in invasive ductal carcinomas. PMID:25521819
The EHEC-host interactome reveals novel targets for the translocated intimin receptor. PMID:25519916
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. PMID:25514926
Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. PMID:25512531
Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma Multiforme. PMID:25502460
Genome-wide association study of kidney function decline in individuals of European descent. PMID:25493955
An improved single-chain Fab platform for efficient display and recombinant expression. PMID:25481745
Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions. PMID:25437919
Prediction of DNA binding motifs from 3D models of transcription factors; identifying TLX3 regulated genes. PMID:25428367
Computational strategies for a system-level understanding of metabolism. PMID:25427076
Bioimaging-based detection of mislocalized proteins in human cancers by semi-supervised learning. PMID:25414362
Expression of human skin-specific genes defined by transcriptomics and antibody-based profiling. PMID:25411189
GWAS identifies four novel eosinophilic esophagitis loci. PMID:25407941
Genetically low vitamin D concentrations and increased mortality: Mendelian randomisation analysis in three large cohorts. PMID:25406188
In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25402006
Multiple mechanisms mediate resistance to sorafenib in urothelial cancer. PMID:25387078
Identification of OLIG2 as the most specific glioblastoma stem cell marker starting from comparative analysis of data from similar DNA chip microarray platforms. PMID:25384509
p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration. PMID:25383540
Evidence for heightened hexokinase II immunoexpression in hepatocyte dysplasia and hepatocellular carcinoma. PMID:25381201
Itch is required for lateral line development in zebrafish. PMID:25369329
Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer. PMID:25368680
TFClass: a classification of human transcription factors and their rodent orthologs. PMID:25361979
Identification of novel tumor-associated cell surface sialoglycoproteins in human glioblastoma tumors using quantitative proteomics. PMID:25360666
Decoding neuroproteomics: integrating the genome, translatome and functional anatomy. PMID:25349915
ComPPI: a cellular compartment-specific database for protein-protein interaction network analysis. PMID:25348397
Genome-wide linkage and exome analyses identify variants of HMCN1 for splenic epidermoid cyst. PMID:25338956
Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue. PMID:25329061
Aberrant levels of histone H3 acetylation induce spermatid anomaly in mouse testis. PMID:25326673
GLUT-1 expression is largely unrelated to both hypoxia and the Warburg phenotype in squamous cell carcinomas of the vulva. PMID:25306097
A clathrin coat assembly role for the muniscin protein central linker revealed by TALEN-mediated gene editing. PMID:25303365
Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity. PMID:25287652
Effect of an anti-human Co-029/tspan8 mouse monoclonal antibody on tumor growth in a nude mouse model. PMID:25285080
Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis. PMID:25284788
CLIP2 as radiation biomarker in papillary thyroid carcinoma. PMID:25284583
Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans. PMID:25250030
Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role. PMID:25225902
Spatiotemporal proteomic analyses during pancreas cancer progression identifies serine/threonine stress kinase 4 (STK4) as a novel candidate biomarker for early stage disease. PMID:25225358
PACE4-based molecular targeting of prostate cancer using an engineered ⁶⁴Cu-radiolabeled peptide inhibitor. PMID:25220591
Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. PMID:25183785
Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma. PMID:25165006
Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer. PMID:25163878
CYP2W1 is highly expressed in adrenal glands and is positively associated with the response to mitotane in adrenocortical carcinoma. PMID:25144458
Transcriptional landscape of glomerular parietal epithelial cells. PMID:25127402
Pregnancy does not increase the local recurrence rate after surgical resection of desmoid-type fibromatosis. PMID:25124238
Drafts of the human proteome. PMID:25101745
Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching. PMID:25097667
Heterogeneous tumor subpopulations cooperate to drive invasion. PMID:25066122
A unique four-hub protein cluster associates to glioblastoma progression. PMID:25050814
Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype. PMID:25038256
New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases. PMID:25036887
Analyzing the first drafts of the human proteome. PMID:25014353
MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome. PMID:25009282
XB130-A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis. PMID:24995146
Highly expressed genes in human high grade gliomas: immunohistochemical analysis of data from the human protein atlas. PMID:24987500
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. PMID:24981863
IIS--Integrated Interactome System: a web-based platform for the annotation, analysis and visualization of protein-metabolite-gene-drug interactions by integrating a variety of data sources and tools. PMID:24949626
Identification of a duplication within the GDF9 gene and novel candidate genes for primary ovarian insufficiency (POI) by a customized high-resolution array comparative genomic hybridization platform. PMID:24939957
Multiple evidence strands suggest that there may be as few as 19,000 human protein-coding genes. PMID:24939910
PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia. PMID:24931394
Genome-wide association analysis identifies six new loci associated with forced vital capacity. PMID:24929828
Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation. PMID:24927551
Affinity proteomics within rare diseases: a BIO-NMD study for blood biomarkers of muscular dystrophies. PMID:24920607
Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis. PMID:24919120
Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells. PMID:24913355
Evaluation of candidate spermatogonial markers ID4 and GPR125 in testes of adult human cadaveric organ donors. PMID:24902969
Biochemical characterization of human gluconokinase and the proposed metabolic impact of gluconic acid as determined by constraint based metabolic network analysis. PMID:24896608
The tumor-associated marker, PVRL4 (nectin-4), is the epithelial receptor for morbilliviruses. PMID:24892636
Exploring mechanisms of diet-colon cancer associations through candidate molecular interaction networks. PMID:24886433
A pan-cancer proteomic perspective on The Cancer Genome Atlas. PMID:24871328
Mass-spectrometry-based draft of the human proteome. PMID:24870543
A draft map of the human proteome. PMID:24870542
Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos. PMID:24858484
Interactions between distant ceRNAs in regulatory networks. PMID:24853754
Robust validation of methylation levels association at CPT1A locus with lipid plasma levels. PMID:24850808
A foundation for reliable spatial proteomics data analysis. PMID:24846987
The use of functional chemical-protein associations to identify multi-pathway renoprotectants. PMID:24830678
Elucidating the interactions between the human gut microbiota and its host through metabolic modeling. PMID:24795748
The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling. PMID:24789573
Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. PMID:24789143
Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction. PMID:24786987
Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. PMID:24776929
Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. PMID:24752081
Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. PMID:24743550
Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. PMID:24741114
Garbage in, garbage out: a critical evaluation of strategies used for validation of immunohistochemical biomarkers. PMID:24725481
Immunoproteomics using polyclonal antibodies and stable isotope-labeled affinity-purified recombinant proteins. PMID:24722731
The dynamic epitranscriptome: N6-methyladenosine and gene expression control. PMID:24713629
SysPTM 2.0: an updated systematic resource for post-translational modification. PMID:24705204
Proteome-wide epitope mapping of antibodies using ultra-dense peptide arrays. PMID:24705123
A human lung xenograft mouse model of Nipah virus infection. PMID:24699832
Whole-genome analysis of temporal gene expression during early transdifferentiation of human lung alveolar epithelial type 2 cells in vitro. PMID:24690998
Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis. PMID:24667490
A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies. PMID:24658685
Translational profiles of medullary myofibroblasts during kidney fibrosis. PMID:24652793
Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. PMID:24646661
Understanding how and why the Gene Ontology and its annotations evolve: the GO within UniProt. PMID:24641996
Nuclear assembly as a target for anti-cancer therapies. PMID:24637400
In silico prediction of protein-protein interactions in human macrophages. PMID:24636261
Decreased decorin expression in the tumor microenvironment. PMID:24634138
Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease. PMID:24628925
Rich annotation of DNA sequencing variants by leveraging the Ensembl Variant Effect Predictor with plugins. PMID:24626529
Expression of histone deacetylases 1, 2 and 3 in urothelial bladder cancer. PMID:24624923
Potential pathway of anti-inflammatory effect by New Zealand honeys. PMID:24623989
CCNA2 is a prognostic biomarker for ER+ breast cancer and tamoxifen resistance. PMID:24622579
ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration. PMID:24618899
BCL2DB: database of BCL-2 family members and BH3-only proteins. PMID:24608034
Quantitative protein localization signatures reveal an association between spatial and functional divergences of proteins. PMID:24603469
A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells. PMID:24596151
COMPARTMENTS: unification and visualization of protein subcellular localization evidence. PMID:24573882
Increased substitution rates surrounding low-complexity regions within primate proteins. PMID:24572016
Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study. PMID:24567419
Expression of neonatal Fc receptor in the eye. PMID:24550358
Identification of oxidized protein hydrolase as a potential prodrug target in prostate cancer. PMID:24512522
PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas. PMID:24510345
Case-only gene-environment interaction between ALAD tagSNPs and occupational lead exposure in prostate cancer. PMID:24500903
Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung. PMID:24500884
Quantitation of human metallothionein isoforms: a family of small, highly conserved, cysteine-rich proteins. PMID:24493013
C2orf62 and TTC17 are involved in actin organization and ciliogenesis in zebrafish and human. PMID:24475127
Pre-B-cell leukemia homeobox interacting protein 1 is overexpressed in astrocytoma and promotes tumor cell growth and migration. PMID:24470547
Inhibiting metastatic breast cancer cell migration via the synergy of targeted, pH-triggered siRNA delivery and chemokine axis blockade. PMID:24467226
Predicting human protein subcellular locations by the ensemble of multiple predictors via protein-protein interaction network with edge clustering coefficients. PMID:24466278
Activation of peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) inhibits human breast cancer cell line tumorigenicity. PMID:24464939
Global analysis reveals the complexity of the human glomerular extracellular matrix. PMID:24436468
Krüppel-like factors in cancer progression: three fingers on the steering wheel. PMID:24429391
Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study. PMID:24426833
The anti-tumor histone deacetylase inhibitor SAHA and the natural flavonoid curcumin exhibit synergistic neuroprotection against amyloid-beta toxicity. PMID:24409332
Constitutive patterns of gene expression regulated by RNA-binding proteins. PMID:24401680
A 660-Kb deletion with antagonistic effects on fertility and milk production segregates at high frequency in Nordic Red cattle: additional evidence for the common occurrence of balancing selection in livestock. PMID:24391517
ALCAM/CD166 is a TGF-β-responsive marker and functional regulator of prostate cancer metastasis to bone. PMID:24385212
Chromatin signature of widespread monoallelic expression. PMID:24381246
Human colonic crypts in culture: segregation of immunochemical markers in normal versus adenoma-derived. PMID:24365748
A novel null homozygous mutation confirms CACNA2D2 as a gene mutated in epileptic encephalopathy. PMID:24358150
PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses. PMID:24337479
Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. PMID:24314139
PaGenBase: a pattern gene database for the global and dynamic understanding of gene function. PMID:24312499
Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. PMID:24309898
CellFinder: a cell data repository. PMID:24304896
Prioritization of cancer marker candidates based on the immunohistochemistry staining images deposited in the human protein atlas. PMID:24303032
Ascites analysis by a microfluidic chip allows tumor-cell profiling. PMID:24297935
A perspective on proteomics in cell biology. PMID:24284280
A cross-platform comparison of affymetrix and Agilent microarrays reveals discordant miRNA expression in lung tumors of c-Raf transgenic mice. PMID:24265725
Detection of the human endogenous retrovirus ERV3-encoded Env-protein in human tissues using antibody-based proteomics. PMID:24262892
Reconstruction and analysis of human kidney-specific metabolic network based on omics data. PMID:24222897
Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression. PMID:24220242
PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling. PMID:24213576
Plasma proteomics, the Human Proteome Project, and cancer-associated alternative splice variant proteins. PMID:24211518
In situ Protein Detection for Companion Diagnostics. PMID:24199171
High-throughput RNA interference screens integrative analysis: Towards a comprehensive understanding of the virus-host interplay. PMID:24175227
Determinants of robustness in spindle assembly checkpoint signalling. PMID:24161933
Sequence signatures extracted from proximal promoters can be used to predict distal enhancers. PMID:24156763
Selectivity analysis of single binder assays used in plasma protein profiling. PMID:24151238
LoQAtE--Localization and Quantitation ATlas of the yeast proteomE. A new tool for multiparametric dissection of single-protein behavior in response to biological perturbations in yeast. PMID:24150937
An essential role for decorin in bladder cancer invasiveness. PMID:24142880
Reassessing target antigens for adoptive T-cell therapy. PMID:24142051
High level of serum AMBP is associated with poor response to paclitaxel-capecitabine chemotherapy in advanced gastric cancer patients. PMID:24135868
Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP. PMID:24113144
The dual role of filamin A in cancer: can't live with (too much of) it, can't live without it. PMID:24108109
Effect of prediabetes on membrane bicarbonate transporters in testis and epididymis. PMID:24105628
Phospho-specific antibodies by design. PMID:24104753
Predicting functional gene interactions with the hierarchical interaction score. PMID:24097268
Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner. PMID:24091309
Cathepsin C is a tissue-specific regulator of squamous carcinogenesis. PMID:24065739
Double-targeting using a TrkC ligand conjugated to dipyrrometheneboron difluoride (BODIPY) based photodynamic therapy (PDT) agent. PMID:24063347
Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle. PMID:24060339
Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. PMID:24043423
TCPA: a resource for cancer functional proteomics data. PMID:24037243
PainNetworks: a web-based resource for the visualisation of pain-related genes in the context of their network associations. PMID:24036287
The evolution of genome-scale models of cancer metabolism. PMID:24027532
PIAS4 is an activator of hypoxia signalling via VHL suppression during growth of pancreatic cancer cells. PMID:24002598
Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia. PMID:23989136
Integration of cardiac proteome biology and medicine by a specialized knowledgebase. PMID:23965338
Pathology imaging informatics for quantitative analysis of whole-slide images. PMID:23959844
metabolicMine: an integrated genomics, genetics and proteomics data warehouse for common metabolic disease research. PMID:23935057
Antibodies biotinylated using a synthetic Z-domain from protein A provide stringent in situ protein detection. PMID:23920108
Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome. PMID:23908630
Disruption of the mouse Jhy gene causes abnormal ciliary microtubule patterning and juvenile hydrocephalus. PMID:23906841
Basic transcription factor 3 is involved in gastric cancer development and progression. PMID:23901224
An analysis of a 'community-driven' reconstruction of the human metabolic network. PMID:23888127
APS8, a polymeric alkylpyridinium salt blocks α7 nAChR and induces apoptosis in non-small cell lung carcinoma. PMID:23880932
Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin. PMID:23879975
Honey bee protein atlas at organ-level resolution. PMID:23878156
LifeMap Discovery™: the embryonic development, stem cells, and regenerative medicine research portal. PMID:23874394
A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. PMID:23871637
Characterization of human thymic exosomes. PMID:23844026
Comparing the Immunoexpression of FUT3 and FUT6 between Prostatic Adenocarcinoma and Benign Prostatic Hyperplasia. PMID:23836950
Using an isolated rat kidney model to identify kidney origin proteins in urine. PMID:23825584
Key genes for modulating information flow play a temporal role as breast tumor coexpression networks are dynamically rewired by letrozole. PMID:23819860
An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression. PMID:23791528
Vandetanib combined with a p38 MAPK inhibitor synergistically reduces glioblastoma cell survival. PMID:23783486
PiHelper: an open source framework for drug-target and antibody-target data. PMID:23766416
An image-based multi-label human protein subcellular localization predictor (iLocator) reveals protein mislocalizations in cancer tissues. PMID:23740749
Autoantibody profiling in multiple sclerosis using arrays of human protein fragments. PMID:23732997
Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure. PMID:23713052
Pathway databases: making chemical and biological sense of the genomic data flood. PMID:23706629
A texture based pattern recognition approach to distinguish melanoma from non-melanoma cells in histopathological tissue microarray sections. PMID:23690928
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. PMID:23685747
Proteome-wide discovery of mislocated proteins in cancer. PMID:23674306
Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis. PMID:23666923
Discovering RNA-protein interactome by using chemical context profiling of the RNA-protein interface. PMID:23665222
Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily. PMID:23659632
Fluorogenic sialic acid glycosides for quantification of sialidase activity upon unnatural substrates. PMID:23639536
RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer. PMID:23635776
Novel insights into obesity and diabetes through genome-scale metabolic modeling. PMID:23630502
Isolation and culture of human spermatogonial stem cells derived from testis biopsy. PMID:23626877
MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL. PMID:23617806
Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy. PMID:23617393
Functional genomic assessment of phosgene-induced acute lung injury in mice. PMID:23590305
Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model. PMID:23569271
The transcription intermediary factor 1β coactivates the androgen receptor. PMID:23563173
Proteasome inhibitor MG-132 induces MCPIP1 expression. PMID:23551903
Elevated ALCAM shedding in colorectal cancer correlates with poor patient outcome. PMID:23539446
Network pharmacology strategies toward multi-target anticancer therapies: from computational models to experimental design principles. PMID:23530504
Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics. PMID:23518503
Immune response profiling identifies autoantibodies specific to Moyamoya patients. PMID:23518061
Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance. PMID:23516528
Integration of clinical data with a genome-scale metabolic model of the human adipocyte. PMID:23511207
Access guide to human proteinpedia. PMID:23504933
Extending the mannose 6-phosphate glycoproteome by high resolution/accuracy mass spectrometry analysis of control and acid phosphatase 5-deficient mice. PMID:23478313
A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. PMID:23459592
A community-driven global reconstruction of human metabolism. PMID:23455439
Peripheral immune cell gene expression changes in advanced non-small cell lung cancer patients treated with first line combination chemotherapy. PMID:23451142
Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. PMID:23435261
Polymorphisms in iron homeostasis genes and urinary cadmium concentrations among nonsmoking women in Argentina and Bangladesh. PMID:23416510
Characterization of ovine Nectin-4, a novel peste des petits ruminants virus receptor. PMID:23388720
Fusion between hematopoietic and epithelial cells in adult human intestine. PMID:23383228
Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice. PMID:23361301
The contribution of systematic approaches to characterizing the proteins and functions of the endoplasmic reticulum. PMID:23359093
Early growth response 3 (Egr3) is highly over-expressed in non-relapsing prostate cancer but not in relapsing prostate cancer. PMID:23342084
Stochastic profiling of transcriptional regulatory heterogeneities in tissues, tumors and cultured cells. PMID:23306461
Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling. PMID:23300935
Parallel immunizations of rabbits using the same antigen yield antibodies with similar, but not identical, epitopes. PMID:23284606
Smg1 haploinsufficiency predisposes to tumor formation and inflammation. PMID:23277562
Unconventional secretion is a major contributor of cancer cell line secretomes. PMID:23268930
The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. PMID:23267855
The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. PMID:23257357
Chromosome 19 annotations with disease speciation: a first report from the Global Research Consortium. PMID:23249167
Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE. PMID:23234303
Multiscale integration of -omic, imaging, and clinical data in biomedical informatics. PMID:23231990
The state of the human proteome in 2012 as viewed through PeptideAtlas. PMID:23215161
Regulation of ROCK activity in cancer. PMID:23204112
Base excision repair in physiology and pathology of the central nervous system. PMID:23203191
TFClass: an expandable hierarchical classification of human transcription factors. PMID:23180794
Analysis of the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) cistrome reveals novel co-regulatory role of ATF4. PMID:23176727
Polyadenylation-dependent control of long noncoding RNA expression by the poly(A)-binding protein nuclear 1. PMID:23166521
Comprehensive analysis of the genome transcriptome and proteome landscapes of three tumor cell lines. PMID:23158748
Dysregulation of RNA polymerase I transcription during disease. PMID:23153826
A gene expression atlas of the domestic pig. PMID:23153189
Mid-gestational gene expression profile in placenta and link to pregnancy complications. PMID:23145134
Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration. PMID:23124355
Validation processes of protein biomarkers in serum--a cross platform comparison. PMID:23112739
Filamin C-related myopathies: pathology and mechanisms. PMID:23109048
Evolution of the human-specific microRNA miR-941. PMID:23093182
Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood samples. PMID:23090970
Popular computational methods to assess multiprotein complexes derived from label-free affinity purification and mass spectrometry (AP-MS) experiments. PMID:23071097
The ontology-based answers (OBA) service: a connector for embedded usage of ontologies in applications. PMID:23060901
Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases. PMID:23054682
Multiplex epitope mapping using bacterial surface display reveals both linear and conformational epitopes. PMID:23050090
IPAD: the Integrated Pathway Analysis Database for Systematic Enrichment Analysis. PMID:23046449
Integrated analysis of tumor samples sheds light on tumor heterogeneity. PMID:23012583
Identification of differentially expressed proteins in direct expressed prostatic secretions of men with organ-confined versus extracapsular prostate cancer. PMID:22986220
High-resolution mapping of linear antibody epitopes using ultrahigh-density peptide microarrays. PMID:22984286
SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome. PMID:22974441
A tool to facilitate clinical biomarker studies--a tissue dictionary based on the Human Protein Atlas. PMID:22971420
A census of human soluble protein complexes. PMID:22939629
Genomic profiling of a human organotypic model of AEC syndrome reveals ZNF750 as an essential downstream target of mutant TP63. PMID:22922031
Postfixation detergent treatment liberates the membrane modelling protein Pex11β from peroxisomal membranes. PMID:22875152
New and improved proteomics technologies for understanding complex biological systems: addressing a grand challenge in the life sciences. PMID:22807061
Cell type specificity of signaling: view from membrane receptors distribution and their downstream transduction networks. PMID:22802048
Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. PMID:22786680
A minimal connected network of transcription factors regulated in human tumors and its application to the quest for universal cancer biomarkers. PMID:22761861
Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions. PMID:22744749
CSE1L, DIDO1 and RBM39 in colorectal adenoma to carcinoma progression. PMID:22711543
Production of tissue microarrays, immunohistochemistry staining and digitalization within the human protein atlas. PMID:22688270
Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain. PMID:22634524
Differential gene expression in the EphA4 knockout spinal cord and analysis of the inflammatory response following spinal cord injury. PMID:22629434
Phosphosignature predicts dasatinib response in non-small cell lung cancer. PMID:22617229
Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT. PMID:22615553
The human proteome - a scientific opportunity for transforming diagnostics, therapeutics, and healthcare. PMID:22583803
Exploring the transcriptome of ciliated cells using in silico dissection of human tissues. PMID:22558177
Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin. PMID:22529955
Bioinformatic identification of proteins with tissue-specific expression for biomarker discovery. PMID:22515324
Scalable in situ hybridization on tissue arrays for validation of novel cancer and tissue-specific biomarkers. PMID:22412953
The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers. PMID:22398720
The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention. PMID:22318237
Advancing cell biology through proteomics in space and time (PROSPECTS). PMID:22311636
A lateral flow protein microarray for rapid and sensitive antibody assays. PMID:22174629
HOMER: a human organ-specific molecular electronic repository. PMID:22165817
A vision for a biomedical cloud. PMID:22142244
neXtProt: a knowledge platform for human proteins. PMID:22139911
TopFIND 2.0--linking protein termini with proteolytic processing and modifications altering protein function. PMID:22102574
dbDEPC 2.0: updated database of differentially expressed proteins in human cancers. PMID:22096234
Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. PMID:22093360
Antibody-based protein profiling of the human chromosome 21. PMID:22042635
Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway. PMID:22038470
Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis. PMID:22037942
Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization. PMID:22002106
A Protein Epitope Signature Tag (PrEST) library allows SILAC-based absolute quantification and multiplexed determination of protein copy numbers in cell lines. PMID:21964433
The gain in brain: novel imaging techniques and multiplexed proteomic imaging of brain tissue ultrastructure. PMID:21944260
Overview of the matrisome--an inventory of extracellular matrix constituents and functions. PMID:21937732
Verification of male infertility biomarkers in seminal plasma by multiplex selected reaction monitoring assay. PMID:21933954
Generation of monospecific antibodies based on affinity capture of polyclonal antibodies. PMID:21898641
Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. PMID:21804561
The AR dependent cell cycle: mechanisms and cancer relevance. PMID:21782001
Deeply dissecting stemness: making sense to non-coding RNAs in stem cells. PMID:21706141
Determinants of antigenicity and specificity in immune response for protein sequences. PMID:21693021
Protein localization as a principal feature of the etiology and comorbidity of genetic diseases. PMID:21613983
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. PMID:21266779 -
A subcellular map of the human proteome
PubMed citations: 896.
896 articles citing: A subcellular map of the human proteome
The Quest for Anti-α-Synuclein Antibody Specificity-Lessons Learnt From Flow Cytometry Analysis. PMID:35911883
The Role of ERBB Signaling Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma and Establishing a Prognostic Risk Assessment Model for Patients. PMID:35903358
lncRNAs Functioned as ceRNA to Sponge miR-15a-5p Affects the Prognosis of Pancreatic Adenocarcinoma and Correlates With Tumor Immune Infiltration. PMID:35899199
Coexpression of TRPML1 and TRPML2 Mucolipin Channels Affects the Survival of Glioblastoma Patients. PMID:35887088
Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage. PMID:35877003
Follistatin-like 1 and its paralogs in heart development and cardiovascular disease. PMID:35867287
Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer. PMID:35846126
COLGALT1 is a potential biomarker for predicting prognosis and immune responses for kidney renal clear cell carcinoma and its mechanisms of ceRNA networks. PMID:35842702
The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. PMID:35840578
Cabin1 domain-containing gene picd-1 interacts with pry-1/Axin to regulate multiple processes in Caenorhabditis elegans. PMID:35835800
DeepBacs for multi-task bacterial image analysis using open-source deep learning approaches. PMID:35810255
Genetic variation associated with condensate dysregulation in disease. PMID:35809564
Advanced Glycation End Products (AGEs) and Chronic Kidney Disease: Does the Modern Diet AGE the Kidney? PMID:35807857
A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic Targets. PMID:35791393
Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter. PMID:35790710
Role of SNAREs in Unconventional Secretion-Focus on the VAMP7-Dependent Secretion. PMID:35784483
Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease. PMID:35782873
Downregulation of DNMT3A Attenuates the Warburg Effect, Proliferation, and Invasion via Promoting the Inhibition of miR-603 on HK2 in Ovarian Cancer. PMID:35770296
Iron-Deficiency in Atopic Diseases: Innate Immune Priming by Allergens and Siderophores. PMID:35769558
Comprehensive analysis of CXCR family members in lung adenocarcinoma with prognostic values. PMID:35768814
Discovering molecular features of intrinsically disordered regions by using evolution for contrastive learning. PMID:35767567
CircRNA circ_0006156 inhibits the metastasis of prostate cancer by blocking the ubiquitination of S100A9. PMID:35760899
The SKBR3 cell-membrane proteome reveals telltales of aberrant cancer cell proliferation and targets for precision medicine applications. PMID:35760832
Comprehensive Analysis of ABCA Family Members in Lung Adenocarcinoma with Prognostic Values. PMID:35759117
Self-supervised learning of cell type specificity from immunohistochemical images. PMID:35758799
Roles of Cadherin2 in Thyroid Cancer. PMID:35756646
Unique SMYD5 Structure Revealed by AlphaFold Correlates with Its Functional Divergence. PMID:35740908
Expression of GOT2 Is Epigenetically Regulated by DNA Methylation and Correlates with Immune Infiltrates in Clear-Cell Renal Cell Carcinoma. PMID:35735610
SubCellBarCode: integrated workflow for robust spatial proteomics by mass spectrometry. PMID:35732783
Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson's disease. PMID:35732154
A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling. PMID:35729113
The Correlation Between Immune Invasion and SARS-COV-2 Entry Protein ADAM17 in Cancer Patients by Bioinformatic Analysis. PMID:35720350
cytoNet: Spatiotemporal network analysis of cell communities. PMID:35696439
Identification of Hub Genes in Colorectal Adenocarcinoma by Integrated Bioinformatics. PMID:35693937
Development and Validation of a Novel PPAR Signaling Pathway-Related Predictive Model to Predict Prognosis in Breast Cancer. PMID:35692496
Screening membraneless organelle participants with machine-learning models that integrate multimodal features. PMID:35687670
Exploratory Investigation of the Plasma Proteome Associated with the Endotheliopathy of Trauma. PMID:35682894
Translocating proteins compartment-specifically alter the fate of epithelial-mesenchymal transition in a compartmentalized Boolean network model. PMID:35680961
Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation. PMID:35676684
An approach to cellular tropism of SARS-CoV-2 through protein-protein interaction and enrichment analysis. PMID:35672403
NAP1L1 Functions as a Novel Prognostic Biomarker Associated With Macrophages and Promotes Tumor Progression by Influencing the Wnt/β-Catenin Pathway in Hepatocellular Carcinoma. PMID:35664324
AnthraxKP: a knowledge graph-based, Anthrax Knowledge Portal mined from biomedical literature. PMID:35653350
Characterisation of a nucleo-adhesome. PMID:35650196
Different Effects on Protein Expression of CDR132L, an Antisense Inhibitor of miR-132, and Standard Therapies for Myocardial Infarction. PMID:35647075
Pattern Analysis of Organellar Maps for Interpretation of Proteomic Data. PMID:35645376
Pyroptosis-related genes regulate proliferation and invasion of pancreatic cancer and serve as the prognostic signature for modeling patient survival. PMID:35633405
Genetic screen identifies non-mitochondrial proteins involved in the maintenance of mitochondrial homeostasis. PMID:35622507
Semaphorin 6D as an independent predictor for better prognosis in clear cell renal cell carcinoma. PMID:35605459
Autoantibody Landscape Revealed by Wet Protein Array: Sum of Autoantibody Levels Reflects Disease Status. PMID:35603173
Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin. PMID:35587511
New biomarker: the gene HLA-DRA associated with low-grade glioma prognosis. PMID:35585639
Updated Functional Roles of NAMPT in Carcinogenesis and Therapeutic Niches. PMID:35565188
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance. PMID:35562425
Peroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells. PMID:35557958
SubcellulaRVis: a web-based tool to simplify and visualise subcellular compartment enrichment. PMID:35536291
PICASSO allows ultra-multiplexed fluorescence imaging of spatially overlapping proteins without reference spectra measurements. PMID:35513404
The prognostic miR-532-5p-correlated ceRNA-mediated lipid droplet accumulation drives nodal metastasis of cervical cancer. PMID:35499057
Construction and Validation of Angiogenesis-Related Prognostic Risk Signature to Facilitate Survival Prediction and Biomarker Excavation of Breast Cancer Patients. PMID:35498539
DeepLoc 2.0: multi-label subcellular localization prediction using protein language models. PMID:35489069
Integrated Analysis of Necroptosis-Related Genes for Prognosis, Immune Microenvironment Infiltration, and Drug Sensitivity in Colon Cancer. PMID:35479956
Size-based isolation and detection of renal carcinoma cells from whole blood. PMID:35463211
Integrated In Silico Analyses Identify PUF60 and SF3A3 as New Spliceosome-Related Breast Cancer RNA-Binding Proteins. PMID:35453681
Reciprocal Regulation of Shh Trafficking and H2O2 Levels via a Noncanonical BOC-Rac1 Pathway. PMID:35453403
Untargeted Metabolomics of Slc13a5 Deficiency Reveal Critical Liver-Brain Axis for Lipid Homeostasis. PMID:35448538
Determining protein polarization proteome-wide using physical dissection of individual Stentor coeruleus cells. PMID:35447087
Glucose metabolism and AD: evidence for a potential diabetes type 3. PMID:35443732
NUSAP1 Could be a Potential Target for Preventing NAFLD Progression to Liver Cancer. PMID:35431924
Membrane marker selection for segmenting single cell spatial proteomics data. PMID:35422106
VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites. PMID:35421371
COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2. PMID:35414771
In Mitosis You Are Not: The NIMA Family of Kinases in Aspergillus, Yeast, and Mammals. PMID:35409400
Unravelling Prostate Cancer Heterogeneity Using Spatial Approaches to Lipidomics and Transcriptomics. PMID:35406474
Proteomic and Single-Cell Transcriptomic Dissection of Human Plasmacytoid Dendritic Cell Response to Influenza Virus. PMID:35401570
Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? PMID:35386996
Predicted coronavirus Nsp5 protease cleavage sites in the human proteome. PMID:35379171
Spatial proteomics reveals subcellular reorganization in human keratinocytes exposed to UVA light. PMID:35372811
Ultrastructural and proteomic profiling of mitochondria-associated endoplasmic reticulum membranes reveal aging signatures in striated muscle. PMID:35368021
Sincast: a computational framework to predict cell identities in single-cell transcriptomes using bulk atlases as references. PMID:35362513
Study on the role of transcription factor SPI1 in the development of glioma. PMID:35361282
The emerging role of mass spectrometry-based proteomics in drug discovery. PMID:35351998
The monoacylglycerol acyltransferase pathway contributes to triacylglycerol synthesis in HepG2 cells. PMID:35322811
Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway. PMID:35318338
Proximity-Dependent Biotinylation Approaches to Explore the Dynamic Compartmentalized Proteome. PMID:35309513
Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease. PMID:35309368
7-Dehydrocholesterol Encapsulated Polymeric Nanoparticles As a Radiation-Responsive Sensitizer for Enhancing Radiation Therapy. PMID:35304816
FAT10 is a Prognostic Biomarker and Correlated With Immune Infiltrates in Skin Cutaneous Melanoma. PMID:35300113
Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma. PMID:35296518
Exploration of the DARTable Genome- a Resource Enabling Data-Driven NAMs for Developmental and Reproductive Toxicity Prediction. PMID:35295108
A multi-omics-based investigation of the immunological and prognostic impact of necroptosis-related genes in patients with hepatocellular carcinoma. PMID:35293027
Salt stress alters membrane lipid content and lipid biosynthesis pathways in the plasma membrane and tonoplast. PMID:35289902
In Vitro Imaging of Lycopene Delivery to Prostate Cancer Cells. PMID:35289593
Advances in Multi-Omics Study of Prognostic Biomarkers of Diffuse Large B-Cell Lymphoma. PMID:35280688
Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety. PMID:35280519
N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion. PMID:35279766
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy. PMID:35276062
OpenCell: Endogenous tagging for the cartography of human cellular organization. PMID:35271311
Identification of a five-gene signature deriving from the vacuolar ATPase (V-ATPase) sub-classifies gliomas and decides prognoses and immune microenvironment alterations. PMID:35266851
A cross-species spatiotemporal proteomic analysis identifies UBE3A-dependent signaling pathways and targets. PMID:35264729
Pan-cancer analysis of osteogenesis imperfecta causing gene SERPINF1. PMID:35261846
A Multielement Prognostic Nomogram Based on a Peripheral Blood Test, Conventional MRI and Clinical Factors for Glioblastoma. PMID:35250826
Novel Therapeutics for Diabetic Retinopathy and Diabetic Macular Edema: A Pathophysiologic Perspective. PMID:35250632
Comprehensive Analysis of Potential Correlation Between Solute Carrier 1A (SLC1A) Family and Lung Adenocarcinoma. PMID:35241927
A Novel Role of Arrhythmia-Related Gene KCNQ1 Revealed by Multi-Omic Analysis: Theragnostic Value and Potential Mechanisms in Lung Adenocarcinoma. PMID:35216393
Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels. PMID:35216288
IL4Rα and IL13Rα1 Are Involved in the Development of Human Gallbladder Cancer. PMID:35207737
Cytoplasmic and Nuclear Functions of cIAP1. PMID:35204822
Leukemia Inhibitory Factor: An Important Cytokine in Pathologies and Cancer. PMID:35204717
Thy-1 (CD90), Integrins and Syndecan 4 are Key Regulators of Skin Wound Healing. PMID:35186924
A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer's disease. PMID:35177665
A human brain vascular atlas reveals diverse mediators of Alzheimer's risk. PMID:35165441
Targeting GPCRs and Their Signaling as a Therapeutic Option in Melanoma. PMID:35158973
Identification of a Novel Nomogram to Predict Progression Based on the Circadian Clock and Insights Into the Tumor Immune Microenvironment in Prostate Cancer. PMID:35154101
Genome-wide RNAi screen identifies novel players in human 60S subunit biogenesis including key enzymes of polyamine metabolism. PMID:35150276
14-3-3 Proteins are Potential Regulators of Liquid-Liquid Phase Separation. PMID:35142991
Human transcription factor protein interaction networks. PMID:35140242
An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking. PMID:35136165
PSL-LCCL: a resource for subcellular protein localization in liver cancer cell line SK_HEP1. PMID:35134877
HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease. PMID:35120281
Computational Methods for Single-Cell Imaging and Omics Data Integration. PMID:35111809
Analysis of the effect of NEKs on the prognosis of patients with non-small-cell lung carcinoma based on bioinformatics. PMID:35105934
Novel Classes and Evolutionary Turnover of Histone H2B Variants in the Mammalian Germline. PMID:35099534
Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury. PMID:35091838
Integrin-linked kinase (ILK): the known vs. the unknown and perspectives. PMID:35089438
Where the Action Is-Leukocyte Recruitment in Atherosclerosis. PMID:35087886
AXIN-AMPK signaling: Implications for healthy aging. PMID:35087668
Simple But Efficacious Enrichment of Integral Membrane Proteins and Their Interactions for In-Depth Membrane Proteomics. PMID:35085786
The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells. PMID:35084980
Serotonin: an overlooked regulator of endocytosis and endosomal sorting? PMID:35076063
Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH. PMID:35076015
Multiple Protein Subcellular Locations Prediction Based on Deep Convolutional Neural Networks with Self-Attention Mechanism. PMID:35066812
CRISPR activation enables high-fidelity reprogramming into human pluripotent stem cells. PMID:35063129
Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B. PMID:35062364
TDP-43 Cytoplasmic Translocation in the Skin Fibroblasts of ALS Patients. PMID:35053327
The Mlc1 Promoter Directs Müller Cell-specific Gene Expression in the Retina. PMID:35040915
A Bioinformatic Analysis of Immune-Related Prognostic Genes in Clear Cell Renal Cell Carcinoma Based on TCGA and GEO Databases. PMID:35035230
Computer-aided design of reversible hybridization chain reaction (CAD-HCR) enables multiplexed single-cell spatial proteomics imaging. PMID:35030012
ARID1A Is a Prognostic Biomarker and Associated with Immune Infiltrates in Hepatocellular Carcinoma. PMID:35028302
The nucleolar δ isoform of adapter protein SH2B1 enhances morphological complexity and function of cultured neurons. PMID:35019135
Comparative Analysis of T-Cell Spatial Proteomics and the Influence of HIV Expression. PMID:35017099
Integrative omics analysis identifies biomarkers of idiopathic pulmonary fibrosis. PMID:35015148
From systems to structure - using genetic data to model protein structures. PMID:35013567
An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes. PMID:35013170
Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression. PMID:35012996
Possible Role of Circulating Bone Marrow Mesenchymal Progenitors in Modulating Inflammation and Promoting Wound Repair. PMID:35008501
Cytosolic Quality Control of Mitochondrial Protein Precursors-The Early Stages of the Organelle Biogenesis. PMID:35008433
Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy. PMID:35005298
Cytochrome b561 Serves as a Potential Prognostic Biomarker and Target for Breast Cancer. PMID:35002301
Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models. PMID:34997121
Identification of ubiquitinated substrate proteins and their gene expression patterns in lung adenocarcinoma. PMID:34988201
Exosomal LBH inhibits epithelial-mesenchymal transition and angiogenesis in nasopharyngeal carcinoma via downregulating VEGFA signaling. PMID:34975330
Super.Complex: A supervised machine learning pipeline for molecular complex detection in protein-interaction networks. PMID:34972161
Quantitative Accuracy and Precision in Multiplexed Single-Cell Proteomics. PMID:34967612
Rich Phase Separation Behavior of Biomolecules. PMID:34966005
C1q/tumor necrosis factor related protein 6 (CTRP6) regulates the phenotypes of high glucose-induced gestational trophoblast cells via peroxisome proliferator-activated receptor gamma (PPARγ) signaling. PMID:34964705
Inositol Phosphates and Retroviral Assembly: A Cellular Perspective. PMID:34960784
Dynamic, but Not Necessarily Disordered, Human-Virus Interactions Mediated through SLiMs in Viral Proteins. PMID:34960638
AHDC1 missense mutations in Xia-Gibbs syndrome. PMID:34950897
Multi-Omics Reveal the Immunological Role and the Theragnostic Value of miR-216a/GDF15 Axis in Human Colon Adenocarcinoma. PMID:34948431
Proteomic Studies of Blood and Vascular Wall in Atherosclerosis. PMID:34948066
The Adenoviral E1B-55k Protein Present in HEK293 Cells Mediates Abnormal Accumulation of Key WNT Signaling Proteins in Large Cytoplasmic Aggregates. PMID:34946869
Deepening into Intracellular Signaling Landscape through Integrative Spatial Proteomics and Transcriptomics in a Lymphoma Model. PMID:34944421
The use of soft X-ray tomography to explore mitochondrial structure and function. PMID:34942399
Comprehensive Analysis of Aldehyde Dehydrogenases (ALDHs) and Its Significant Role in Hepatocellular Carcinoma. PMID:34928471
EASINESS: E. coli Assisted Speedy affINity-maturation Evolution SyStem. PMID:34925322
Subcellular Transcriptomics and Proteomics: A Comparative Methods Review. PMID:34922010
KRAS mutation-independent downregulation of MAPK/PI3K signaling in colorectal cancer. PMID:34919787
MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway. PMID:34910513
Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS-Hook-FHIP complexes. PMID:34882091
Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution. PMID:34876567
B0AT1 Amino Acid Transporter Complexed With SARS-CoV-2 Receptor ACE2 Forms a Heterodimer Functional Unit: In Situ Conformation Using Radiation Inactivation Analysis. PMID:34847569
Alkyne-Tagged Apigenin, a Chemical Tool to Navigate Potential Targets of Flavonoid Anti-Dengue Leads. PMID:34834059
The Rpd3-Complex Regulates Expression of Multiple Cell Surface Recycling Factors in Yeast. PMID:34830359
Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes. PMID:34829980
Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies. PMID:34829671
Applications of CRISPR-Cas Technologies to Proteomics. PMID:34828396
Improving Protein Subcellular Location Classification by Incorporating Three-Dimensional Structure Information. PMID:34827605
A multi-scale map of cell structure fusing protein images and interactions. PMID:34819669
Feedback Loop Regulation between Pim Kinases and Tax Keeps Human T-Cell Leukemia Virus Type 1 Viral Replication in Check. PMID:34818069
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging. PMID:34811556
Clinical Relevance and Prognostic Value of the Neuronal Protein Neuroligin 2 in Breast Cancer. PMID:34804909
Predicting Human Protein Subcellular Locations by Using a Combination of Network and Function Features. PMID:34804131
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. PMID:34800366
ATRX proximal protein associations boast roles beyond histone deposition. PMID:34780483
Deacetylation of Transcription Factors in Carcinogenesis. PMID:34769241
Deliver on Time or Pay the Fine: Scheduling in Membrane Trafficking. PMID:34769203
Prognostic biomarkers for predicting papillary thyroid carcinoma patients at high risk using nine genes of apoptotic pathway. PMID:34767591
The Human Proteoform Project: Defining the human proteome. PMID:34767442
Computational methods for protein localization prediction. PMID:34765098
Identification of hub genes and transcription factor-miRNA-mRNA pathways in mice and human renal ischemia-reperfusion injury. PMID:34754625
Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer's disease brain. PMID:34742335
Advances in integrative African genomics. PMID:34740451
An In-Silico, In-Vitro and In-Vivo Combined Approach to Identify NMNATs as Potential Protein Targets of ProEGCG for Treatment of Endometriosis. PMID:34721014
Fully human recombinant antibodies against EphA2 from a multi-tumor patient immune library suitable for tumor-targeted therapy. PMID:34709992
Analysing a Novel RNA-Binding-Protein-Related Prognostic Signature Highly Expressed in Breast Cancer. PMID:34707800
A working model for condensate RNA-binding proteins as matchmakers for protein complex assembly. PMID:34706978
Predicting subcellular location of protein with evolution information and sequence-based deep learning. PMID:34686152
NUAK Kinases: Brain-Ovary Axis. PMID:34685740
Cellular Protein Phosphatase 2A Regulates Cell Survival Mechanisms in Influenza A Virus Infection. PMID:34681823
Phoenixin as a New Target in the Development of Strategies for Endometriosis Diagnosis and Treatment. PMID:34680544
Development and Validation of a Prognostic Model of RNA-Binding Proteins in Colon Adenocarcinoma: A Study Based on TCGA and GEO Databases. PMID:34675667
COVID-19 disease and malignant cancers: The impact for the furin gene expression in susceptibility to SARS-CoV-2. PMID:34671211
Deciphering the link between Diabetes mellitus and SARS-CoV-2 infection through differential targeting of microRNAs in the human pancreas. PMID:34669152
A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy. PMID:34663427
Lights, Camera, Interaction: Studying Protein-Protein Interactions of the ER Protein Translocase in Living Cells. PMID:34638699
Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer. PMID:34628286
Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma. PMID:34621750
Genetic variants in the p53 pathway influence implantation and pregnancy maintenance in IVF treatments using donor oocytes. PMID:34618298
DeepLearnMOR: a deep-learning framework for fluorescence image-based classification of organelle morphology. PMID:34618108
Testicular Nuclear Receptor 4 Regulates Proliferation and Apoptosis of Bladder Cancer via Bcl-2. PMID:34616769
Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients. PMID:34616010
Transcriptomic analysis revealed increased expression of genes involved in keratinization in the tears of COVID-19 patients. PMID:34615949
Activators of alpha synuclein expression identified by reporter cell line-based high throughput drug screen. PMID:34615900
Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma. PMID:34607313
Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line. PMID:34599159
A protein interaction landscape of breast cancer. PMID:34591612
Impact of depression and stress on placental DNA methylation in ethnically diverse pregnant women. PMID:34585950
The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes. PMID:34577099
Novel Approach Combining Transcriptional and Evolutionary Signatures to Identify New Multiciliation Genes. PMID:34573434
Vorinostat (SAHA) and Breast Cancer: An Overview. PMID:34572928
Circadian Organelles: Rhythms at All Scales. PMID:34572096
Construction of circRNA-based ceRNA network and its prognosis-associated subnet of clear cell renal cell carcinoma. PMID:34569727
Chromobox Homolog 8 (CBX8) in Human Tumor Carcinogenesis and Prognosis: A Pancancer Analysis Using Multiple Databases. PMID:34567093
Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas. PMID:34566896
PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression. PMID:34561473
D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain. PMID:34556581
Pan-cancer proteogenomic investigations identify post-transcriptional kinase targets. PMID:34552204
RNALocate v2.0: an updated resource for RNA subcellular localization with increased coverage and annotation. PMID:34551440
CSCD2: an integrated interactional database of cancer-specific circular RNAs. PMID:34551437
Subcellular proteomics. PMID:34549195
Physical and Functional Interaction of Mitochondrial Single-Stranded DNA-Binding Protein and the Catalytic Subunit of DNA Polymerase Gamma. PMID:34539752
Proteogenomic characterization of pancreatic ductal adenocarcinoma. PMID:34534465
A membrane protein display platform for receptor interactome discovery. PMID:34531301
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. PMID:34530870
Enzymatically Forming Intranuclear Peptide Assemblies for Selectively Killing Human Induced Pluripotent Stem Cells. PMID:34528792
MULocDeep: A deep-learning framework for protein subcellular and suborganellar localization prediction with residue-level interpretation. PMID:34522290
Fluorescence Imaging-Based Discovery of Membrane Domain-Associated Proteins in Mycobacterium smegmatis. PMID:34516286
The molecular mechanism of RIG-I activation and signaling. PMID:34514601
ESPL1 Is a Novel Prognostic Biomarker Associated With the Malignant Features of Glioma. PMID:34512713
Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43266-283 in Glioblastoma Stem Cells. PMID:34503072
Longitudinal peripheral tissue RNA-Seq transcriptomic profiling, hyperalgesia, and wound healing in the rat plantar surgical incision model. PMID:34499774
Proximity labeling and other novel mass spectrometric approaches for spatiotemporal protein dynamics. PMID:34496693
A Novel Ferroptosis-Related Prognostic Signature Reveals Macrophage Infiltration and EMT Status in Bladder Cancer. PMID:34490263
Identification of the Real Hub Gene and Construction of a Novel Prognostic Signature for Pancreatic Adenocarcinoma Based on the Weighted Gene Co-expression Network Analysis and Least Absolute Shrinkage and Selection Operator Algorithms. PMID:34490033
Introducing Thioredoxin-Related Transmembrane Proteins: Emerging Roles of Human TMX and Clinical Implications. PMID:34465218
TLX, an Orphan Nuclear Receptor With Emerging Roles in Physiology and Disease. PMID:34463725
Fluorescent small-molecule agonists as follicle-stimulating hormone receptor imaging tools. PMID:34458765
Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities. PMID:34458747
Survival-Based Biomarker Module Identification Associated with Oral Squamous Cell Carcinoma (OSCC). PMID:34439992
Bothrops Jararaca Snake Venom Modulates Key Cancer-Related Proteins in Breast Tumor Cell Lines. PMID:34437390
Lipid Transporters Beam Signals from Cell Membranes. PMID:34436325
DeepHistoClass: A Novel Strategy for Confident Classification of Immunohistochemistry Images Using Deep Learning. PMID:34425263
Screening of DNA Damage Repair Genes Involved in the Prognosis of Triple-Negative Breast Cancer Patients Based on Bioinformatics. PMID:34408776
Spatiotemporally-resolved mapping of RNA binding proteins via functional proximity labeling reveals a mitochondrial mRNA anchor promoting stress recovery. PMID:34404792
Bioinformatics analysis of the transcriptional expression of minichromosome maintenance proteins as potential indicators of survival in patients with cervical cancer. PMID:34404366
Identification of prognostic and bone metastatic alternative splicing signatures in bladder cancer. PMID:34402716
New mechanistic insights to PLOD1-mediated human vascular disease. PMID:34400365
Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples. PMID:34392148
Expanding the potential genes of inborn errors of immunity through protein interactions. PMID:34391382
The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells. PMID:34374812
Shared genomic segment analysis in a large high-risk chronic lymphocytic leukemia pedigree implicates CXCR4 in inherited risk. PMID:34368645
The Role of DND1 in Cancers. PMID:34359581
Basic principles of hydrogel-based tissue transformation technologies and their applications. PMID:34358468
Pipelines and Systems for Threshold-Avoiding Quantification of LC-MS/MS Data. PMID:34355890
Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements. PMID:34354237
Precision genetic cellular models identify therapies protective against ER stress. PMID:34354042
Characterization of Five Transmembrane Proteins: With Focus on the Tweety, Sideroflexin, and YIP1 Domain Families. PMID:34350187
White button mushroom interrupts tissue AR-mediated TMPRSS2 expression and attenuates pro-inflammatory cytokines in C57BL/6 mice. PMID:34341347
PScL-HDeep: image-based prediction of protein subcellular location in human tissue using ensemble learning of handcrafted and deep learned features with two-layer feature selection. PMID:34337652
Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling. PMID:34337357
Spectrum of Protein Location in Proteomes Captures Evolutionary Relationship Between Species. PMID:34328525
The human melanoma proteome atlas-Defining the molecular pathology. PMID:34323403
The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice. PMID:34315245
A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. PMID:34312566
Scientific Discovery Games for Biomedical Research. PMID:34308269
Identification of Arp2/3 Complex Subunits as Prognostic Biomarkers for Hepatocellular Carcinoma. PMID:34307456
Study on HOXBs of Clear Cell Renal Cell Carcinoma and Detection of New Molecular Target. PMID:34306077
Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer. PMID:34291087
ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease. PMID:34290711
Development and validation of a novel epigenetic-related prognostic signature and candidate drugs for patients with lung adenocarcinoma. PMID:34285141
The promiscuity of the oxytocin-vasopressin systems and their involvement in autism spectrum disorder. PMID:34266588
Single-cell omics analyses with single molecular detection: challenges and perspectives. PMID:34253696
Integrative analysis of key candidate genes and signaling pathways in ovarian cancer by bioinformatics. PMID:34253236
Identification of an Metabolic Related Risk Signature Predicts Prognosis in Cervical Cancer and Correlates With Immune Infiltration. PMID:34249930
Glycolysis-Related Gene Expression Profiling Screen for Prognostic Risk Signature of Pancreatic Ductal Adenocarcinoma. PMID:34249078
MaxDIA enables library-based and library-free data-independent acquisition proteomics. PMID:34239088
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma. PMID:34231338
GNRH1 and LTB4R might be novel immune-related prognostic biomarkers in clear cell renal cell carcinoma (ccRCC). PMID:34229684
Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein. PMID:34201556
RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site. PMID:34193876
Super.Complex: A supervised machine learning pipeline for molecular complex detection in protein-interaction networks. PMID:34189530
A Bayesian semi-parametric model for thermal proteome profiling. PMID:34188175
Chemoproteomic Approach toward Probing the Interactomes of Perfluoroalkyl Substances. PMID:34185510
Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study. PMID:34180758
The Role of GIP Receptor in the CNS for the Pathogenesis of Obesity. PMID:34176784
Dysregulation of the secretory pathway connects Alzheimer's disease genetics to aggregate formation. PMID:34171228
FINER: enhancing the prediction of tissue-specific functions of isoforms by refining isoform interaction networks. PMID:34169280
Endosomal cAMP production broadly impacts the cellular phosphoproteome. PMID:34166681
G protein-coupled receptor kinases are associated with Alzheimer's disease pathology. PMID:34164834
High-resolution transcriptional landscape of xeno-free human induced pluripotent stem cell-derived cerebellar organoids. PMID:34155230
Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation. PMID:34154587
Automated tracking of S. pombe spindle elongation dynamics. PMID:34152622
Identification of significant genes and therapeutic agents for breast cancer by integrated genomics. PMID:34151730
CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients. PMID:34149710
Single-cell image analysis to explore cell-to-cell heterogeneity in isogenic populations. PMID:34139168
Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. PMID:34133714
The increased expression and aberrant methylation of SHC1 in non-small cell lung cancer: Integrative analysis of clinical and bioinformatics databases. PMID:34117717
Differential Regulation of GPCRs-Are GRK Expression Levels the Key? PMID:34109182
A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy. PMID:34106735
Transcriptomics Identify Thrombospondin-2 as a Biomarker for NASH and Advanced Liver Fibrosis. PMID:34105780
A proximity-dependent biotinylation map of a human cell. PMID:34079125
GABARAP ameliorates IL-1β-induced inflammatory responses and osteogenic differentiation in bone marrow-derived stromal cells by activating autophagy. PMID:34078931
ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization. PMID:34074767
The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma. PMID:34067658
Proteomics, Personalized Medicine and Cancer. PMID:34063807
In vivo gene editing via homology-independent targeted integration for adrenoleukodystrophy treatment. PMID:34058389
Gender May Influence the Immunosuppressive Actions of Prednisone in Young Patients With Inflammatory Bowel Disease. PMID:34054855
Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics. PMID:34052751
Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants' spike protein-an in silico analysis. PMID:34038453
Up-regulated RFC2 predicts unfavorable progression in hepatocellular carcinoma. PMID:34022962
µ-Crystallin: A thyroid hormone binding protein. PMID:34020530
Comprehensive analysis of the prognostic value and immune function of the IDO1 gene in gynecological cancers. PMID:34017374
Mitochondrial proteome of mouse oocytes and cisplatin-induced shifts in protein profile. PMID:34017067
Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19. PMID:34009288
Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy. PMID:34000301
MTFR2, A Potential Biomarker for Prognosis and Immune Infiltrates, Promotes Progression of Gastric Cancer Based on Bioinformatics Analysis and Experiments. PMID:33995638
HSP90-dependent PUS7 overexpression facilitates the metastasis of colorectal cancer cells by regulating LASP1 abundance. PMID:33990203
A subcellular map of the human kinome. PMID:33988507
Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer. PMID:33981003
CoffeeProt: an online tool for correlation and functional enrichment of systems genetics data. PMID:33978718
Development and validation of an oxidative stress-associated prognostic risk model for melanoma. PMID:33976978
Validation of the functions and prognostic values of synapse-associated proteins in lower-grade glioma. PMID:33969375
Downregulation of GLYAT Facilitates Tumor Growth and Metastasis and Poor Clinical Outcomes Through the PI3K/AKT/Snail Pathway in Human Breast Cancer. PMID:33968740
Integrated Analysis to Identify a Redox-Related Prognostic Signature for Clear Cell Renal Cell Carcinoma. PMID:33968297
Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa. PMID:33963188
Prognostic value of members of NFAT family for pan-cancer and a prediction model based on NFAT2 in bladder cancer. PMID:33962392
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. PMID:33961781
Ferret Interferon (IFN)-Inducible Transmembrane Proteins Are Upregulated by both IFN-α and Influenza Virus Infection. PMID:33952646
Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence. PMID:33947761
The Human 2-Cys Peroxiredoxins form Widespread, Cysteine-Dependent- and Isoform-Specific Protein-Protein Interactions. PMID:33923941
IFN-λ Modulates the Migratory Capacity of Canine Mammary Tumor Cells via Regulation of the Expression of Matrix Metalloproteinases and Their Inhibitors. PMID:33922837
Multiplexed In Situ Protein Profiling with High-Performance Cleavable Fluorescent Tyramide. PMID:33921211
Functional Roles of SPINK1 in Cancers. PMID:33916984
CRISPR Co-Editing Strategy for Scarless Homology-Directed Genome Editing. PMID:33916763
A molecular single-cell lung atlas of lethal COVID-19. PMID:33915568
CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Acting in cis. PMID:33910952
The occurrence order and cross-talk of different tRNA modifications. PMID:33881742
Statistical mechanics meets single-cell biology. PMID:33875884
Multifactorial Traits of SARS-CoV-2 Cell Entry Related to Diverse Host Proteases and Proteins. PMID:33875625
Establishment and validation of a prognostic signature for lung adenocarcinoma based on metabolism-related genes. PMID:33858449
Development and validation of a prediction model for lung adenocarcinoma based on RNA-binding protein. PMID:33850871
Novel insights in cell cycle dysregulation during prostate cancer progression. PMID:33830069
Regulation of Synaptic Transmission and Plasticity by Protein Phosphatase 1. PMID:33827970
Identifying Molecular Signatures of Distinct Modes of Collective Migration in Response to the Microenvironment Using Three-Dimensional Breast Cancer Models. PMID:33804802
Leptin Is Associated with Poor Clinical Outcomes and Promotes Clear Cell Renal Cell Carcinoma Progression. PMID:33804101
Relevance of 2'-O-Methylation and Pseudouridylation for the Malignant Melanoma. PMID:33803145
Leptin and Cancer: Updated Functional Roles in Carcinogenesis, Therapeutic Niches, and Developments. PMID:33799880
Data science in cell imaging. PMID:33795377
Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B-related hepatocellular carcinoma. PMID:33783990
Atypical focal segmental glomerulosclerosis associated with a new PODXL nonsense variant. PMID:33780168
Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19. PMID:33767597
PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. PMID:33764618
Thiopurines activate an antiviral unfolded protein response that blocks influenza A virus glycoprotein accumulation. PMID:33762409
Knockdown of TMED3 inhibits cell viability and migration and increases apoptosis in human chordoma cells. PMID:33760171
A Novel Metabolism-Related Signature as a Candidate Prognostic Biomarker for Hepatocellular Carcinoma. PMID:33758763
Integrated Redox Proteomic Analysis Highlights New Mechanisms of Sensitivity to Silver Nanoparticles. PMID:33757833
Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans. PMID:33749590
TMBIM6, a potential virus target protein identified by integrated multiomics data analysis in SARS-CoV-2-infected host cells. PMID:33744846
Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes. PMID:33739838
Nidogen-1 expression is associated with overall survival and temozolomide sensitivity in low-grade glioma patients. PMID:33735110
Targeting FAK in anticancer combination therapies. PMID:33731845
Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease. PMID:33730931
The roles of Polycomb repressive complexes in mammalian development and cancer. PMID:33723438
MYCN Drives a Tumor Immunosuppressive Environment Which Impacts Survival in Neuroblastoma. PMID:33718189
Astrocytes, Noradrenaline, α1-Adrenoreceptors, and Neuromodulation: Evidence and Unanswered Questions. PMID:33716677
Human OVCA2 and its homolog FSH3-induced apoptosis in Saccharomyces cerevisiae. PMID:33715035
Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage. PMID:33692365
Increased numbers of nucleoli in a genome-wide RNAi screen reveal proteins that link the cell cycle to RNA polymerase I transcription. PMID:33689394
RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors. PMID:33684443
Harnessing the cDC1-NK Cross-Talk in the Tumor Microenvironment to Battle Cancer. PMID:33679726
Convolutional Neural Network-Based Artificial Intelligence for Classification of Protein Localization Patterns. PMID:33670112
Zinc Finger Protein CTCF Regulates Extracellular Matrix (ECM)-Related Gene Expression Associated With the Wnt Signaling Pathway in Gastric Cancer. PMID:33665169
Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancer. PMID:33664239
Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis. PMID:33663112
A Protocol to Map the Spatial Proteome Using HyperLOPIT in Saccharomyces cerevisiae. PMID:33654815
Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia. PMID:33649590
Phenotypic and protein localization heterogeneity associated with AHDC1 pathogenic protein-truncating alleles in Xia-Gibbs syndrome. PMID:33644933
Two Targets, One Hit: new Anticancer Therapeutics to Prevent Tumorigenesis Without Cardiotoxicity. PMID:33643029
Heterozygous COL9A3 variants cause severe peripheral vitreoretinal degeneration and retinal detachment. PMID:33633367
Spatiotemporal dissection of the cell cycle with single-cell proteogenomics. PMID:33627808
ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition. PMID:33613118
Computational Screening of Phase-separating Proteins. PMID:33610793
Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2. PMID:33609069
Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells. PMID:33589679
COCO/DAND5 inhibits developmental and pathological ocular angiogenesis. PMID:33587337
Human Cerebral Cortex Proteome of Fragile X-Associated Tremor/Ataxia Syndrome. PMID:33585555
Highly Sensitive and Multiplexed Protein Imaging With Cleavable Fluorescent Tyramide Reveals Human Neuronal Heterogeneity. PMID:33585449
Construction of an RNA-Binding Protein-Related Prognostic Model for Pancreatic Adenocarcinoma Based on TCGA and GTEx Databases. PMID:33584809
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome. PMID:33579698
Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs. PMID:33574136
Structural and Functional Diversity among Five RING Finger Proteins from Carassius Auratus Herpesvirus (CaHV). PMID:33562288
Integrated analysis identifies oxidative stress genes associated with progression and prognosis in gastric cancer. PMID:33558567
An expanding spectrum of complications in isolated methylmalonic aciduria. PMID:33554499
Engineered Tools to Study Intercellular Communication. PMID:33552865
Nanoscopic subcellular imaging enabled by ion beam tomography. PMID:33542220
4-Hydroxyphenylpyruvate Dioxygenase-Like Protein Promotes Pancreatic Cancer Cell Progression and Is Associated With Glutamine-Mediated Redox Balance. PMID:33537239
OmicsVolcano: software for intuitive visualization and interactive exploration of high-throughput biological data. PMID:33532728
ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues. PMID:33514423
A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis. PMID:33513212
Peroxisomal Metabolite and Cofactor Transport in Humans. PMID:33505966
DM3Loc: multi-label mRNA subcellular localization prediction and analysis based on multi-head self-attention mechanism. PMID:33503258
Expression and prognostic analyses of SCAMPs in pancreatic adenocarcinoma. PMID:33493138
Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model. PMID:33456582
The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases? PMID:33451033
The maximum growth rate hypothesis is correct for eukaryotic photosynthetic organisms, but not cyanobacteria. PMID:33449358
A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery. PMID:33446713
Investigation of MicroRNA and transcription factor mediated regulatory network for silicosis using systems biology approach. PMID:33446673
Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro Models. PMID:33445709
Design of an Imaging Probe to Monitor Real-Time Redistribution of L-type Voltage-Gated Calcium Channels in Astrocytic Glutamate Signaling. PMID:33432518
Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum. PMID:33419470
Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders. PMID:33414502
Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome. PMID:33406800
Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1. PMID:33402344
Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress. PMID:33398195
Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion. PMID:33398037
The role of Neuropilin-1 in COVID-19. PMID:33395426
Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma. PMID:33390805
Bioinformatics Analyses of Potential miRNA-mRNA Regulatory Axis in HBV-related Hepatocellular Carcinoma. PMID:33390802
Interactions between nascent proteins translated by adjacent ribosomes drive homomer assembly. PMID:33384371
Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia. PMID:33375680
Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition. PMID:33374830
Identification of Hub Prognosis-Associated Oxidative Stress Genes in Pancreatic Cancer Using Integrated Bioinformatics Analysis. PMID:33363572
State of the Field in Multi-Omics Research: From Computational Needs to Data Mining and Sharing. PMID:33362867
Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer. PMID:33342045
Systems biology in cardiovascular disease: a multiomics approach. PMID:33340009
Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains. PMID:33334883
IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates. PMID:33324675
Tools for the Recognition of Sorting Signals and the Prediction of Subcellular Localization of Proteins From Their Amino Acid Sequences. PMID:33324450
Comprehensive analysis of the functions and prognostic significance of RNA-binding proteins in bladder urothelial carcinoma. PMID:33312357
Actin-Membrane Release Initiates Cell Protrusions. PMID:33308479
An APEX2 proximity ligation method for mapping interactions with the nuclear lamina. PMID:33306092
Genetic interaction mapping informs integrative structure determination of protein complexes. PMID:33303586
GCNG: graph convolutional networks for inferring gene interaction from spatial transcriptomics data. PMID:33303016
Identification of SRSF10 as a regulator of SMN2 ISS-N1. PMID:33300159
Visualizing subcellular rearrangements in intact β cells using soft x-ray tomography. PMID:33298443
Identification of a Functional ceRNA Network to Explore Potential Biomarkers for Hepatocellular Carcinoma. PMID:33293827
Tandem Mass Tag-based quantitative proteomics analysis of metabolic associated fatty liver disease induced by high fat diet in mice. PMID:33292312
Prospects for Using Expression Patterns of Paramyxovirus Receptors as Biomarkers for Oncolytic Virotherapy. PMID:33291506
Effect of EGLN1 Genetic Polymorphisms on Hemoglobin Concentration in Andean Highlanders. PMID:33282944
Quantitative Imaging of Biochemistry in Situ and at the Nanoscale. PMID:33274271
Soluble 4R0N Tau Abrogates Endocytic Vesicular Dynamics. PMID:33250760
PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2). PMID:33245768
Multiple functions of TBCK protein in neurodevelopment disorders and tumors. PMID:33240423
Spatial proteomics defines the content of trafficking vesicles captured by golgin tethers. PMID:33239640
Global and Site-Specific Effect of Phosphorylation on Protein Turnover. PMID:33238149
KIAA0101 as a new diagnostic and prognostic marker, and its correlation with gene regulatory networks and immune infiltrates in lung adenocarcinoma. PMID:33231570
Longitudinal Transcriptomic Profiling in Carrageenan-Induced Rat Hind Paw Peripheral Inflammation and Hyperalgesia Reveals Progressive Recruitment of Innate Immune System Components. PMID:33227508
Pooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real time. PMID:33203764
A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project. PMID:33197228
Comprehensive Analysis of ATP6V1s Family Members in Renal Clear Cell Carcinoma With Prognostic Values. PMID:33194650
DPPN-SVM: Computational Identification of Mis-Localized Proteins in Cancers by Integrating Differential Gene Expressions With Dynamic Protein-Protein Interaction Networks. PMID:33193746
Theoretical and in silico Analyses Reveal MYC as a Dynamic Network Biomarker in Colon and Rectal Cancer. PMID:33193630
Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats. PMID:33193103
CRISPR-Mediated Isogenic Cell-SELEX Approach for Generating Highly Specific Aptamers Against Native Membrane Proteins. PMID:33184583
A semi-supervised Bayesian approach for simultaneous protein sub-cellular localisation assignment and novelty detection. PMID:33166281
Genetic and epigenetic factors determining NAFLD risk. PMID:33160101
The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma. PMID:33154775
Modified base-binding EVE and DCD domains: striking diversity of genomic contexts in prokaryotes and predicted involvement in a variety of cellular processes. PMID:33148243
The Human Protein Atlas-Spatial localization of the human proteome in health and disease. PMID:33146890
The Complexity and Dynamics of the Tissue Glycoproteome Associated With Prostate Cancer Progression. PMID:33127837
Systemic analyses of expression patterns and clinical features for GIMAPs family members in lung adenocarcinoma. PMID:33115964
A large-scale optical microscopy image dataset of potato tuber for deep learning based plant cell assessment. PMID:33110087
Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of human NHE3 regulating its expression and activity. PMID:33095475
SON and SRRM2 are essential for nuclear speckle formation. PMID:33095160
Ubiquitomics: An Overview and Future. PMID:33080838
NF-κB2 and RELB offer prognostic information in colorectal cancer and NFKB2 rs7897947 represents a genetic risk factor for disease development. PMID:33074124
Ovarian cancer cells direct monocyte differentiation through a non-canonical pathway. PMID:33069212
A high-stringency blueprint of the human proteome. PMID:33067450
A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions. PMID:33053376
A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling. PMID:33052901
Early-pregnancy transcriptome signatures of preeclampsia: from peripheral blood to placenta. PMID:33046794
Complementary mesoscale dynamics of spectrin and acto-myosin shape membrane territories during mechanoresponse. PMID:33037189
A New Prognostic Risk Model Based on PPAR Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma. PMID:33029112
A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer. PMID:33024794
Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death. PMID:33024077
TOP2A and CENPF are synergistic master regulators activated in cervical cancer. PMID:33023625
Aggregation and disaggregation features of the human proteome. PMID:33022891
G-Quadruplex Helicase DHX36/G4R1 Engages Nuclear Lamina Proteins in Quiescent Breast Cancer Cells. PMID:33015511
Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19. PMID:33000221
Single cell sequencing unraveling genetic basis of severe COVID19 in obesity. PMID:32995660
Cell-Type-Specific Proteogenomic Signal Diffusion for Integrating Multi-Omics Data Predicts Novel Schizophrenia Risk Genes. PMID:32984858
BITS2019: the sixteenth annual meeting of the Italian society of bioinformatics. PMID:32938383
Large-scale prediction and analysis of protein sub-mitochondrial localization with DeepMito. PMID:32938368
Consistency and variation of protein subcellular location annotations. PMID:32935893
Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements. PMID:32934780
TMEM206 is a potential prognostic marker of hepatocellular carcinoma. PMID:32934741
Prognostic effects of the expression of inhibitor of DNA-binding family members on patients with lung adenocarcinoma. PMID:32934711
An era of single-cell genomics consortia. PMID:32929222
Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism. PMID:32927708
Prospective evaluation of the lymph node proteome in dogs with multicentric lymphoma supplemented with sulforaphane. PMID:32926463
Pinpointing Cell Identity in Time and Space. PMID:32923457
The Stress-Like Cancer Cell State Is a Consistent Component of Tumorigenesis. PMID:32910905
Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton's Jelly-Derived Mesenchymal Stem Cells. PMID:32899389
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. PMID:32886496
Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis. PMID:32878998
Low Baseline Pulmonary Levels of Cytotoxic Lymphocytes as a Predisposing Risk Factor for Severe COVID-19. PMID:32873611
Genetics meets proteomics: perspectives for large population-based studies. PMID:32860016
Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion. PMID:32859368
Computer-Aided Whole-Cell Design: Taking a Holistic Approach by Integrating Synthetic With Systems Biology. PMID:32850764
Biological Landscape of Triple Negative Breast Cancers Expressing CTLA-4. PMID:32850353
Novel monoclonal antibodies to the SERINC5 HIV-1 restriction factor detect endogenous andvirion-associated SERINC5. PMID:32835602
Adenosine-Induced NLRP11 in B Lymphoblasts Suppresses Human CD4+ T Helper Cell Responses. PMID:32832566
A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes. PMID:32826910
The intermembrane space protein Mix23 is a novel stress-induced mitochondrial import factor. PMID:32826315
Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells. PMID:32823874
Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development. PMID:32813698
Enzymatic Noncovalent Synthesis. PMID:32812754
The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes. PMID:32811853
Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis? PMID:32811540
Anti-rods/rings autoantibody and IMPDH filaments: an update after fifteen years of discovery. PMID:32805424
Nanoscale Viscosity of Cytoplasm Is Conserved in Human Cell Lines. PMID:32787203
Expression and clinical significance of methyl-CpG binding domain protein 2 in high-grade serous ovarian cancer. PMID:32782591
Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions. PMID:32770072
Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines. PMID:32764586
Current Knowledge on the Function of α-Methyl Acyl-CoA Racemase in Human Diseases. PMID:32760737
Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder. PMID:32744794
Mining the prognostic significance of the GINS2 gene in human breast cancer using bioinformatics analysis. PMID:32724372
Piggybacking on Classical Import and Other Non-Classical Mechanisms of Nuclear Import Appear Highly Prevalent within the Human Proteome. PMID:32718019
The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis. PMID:32717840
Bi-allelic HPDL Variants Cause a Neurodegenerative Disease Ranging from Neonatal Encephalopathy to Adolescent-Onset Spastic Paraplegia. PMID:32707086
Identification of potential markers for type 2 diabetes mellitus via bioinformatics analysis. PMID:32705173
An information-theoretic approach for measuring the distance of organ tissue samples using their transcriptomic signatures. PMID:32683449
Brainstem Organoids From Human Pluripotent Stem Cells. PMID:32670003
Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells. PMID:32664515
Cancer systems immunology. PMID:32657757
Prevention of Neurite Spine Loss Induced by Dopamine D2 Receptor Overactivation in Striatal Neurons. PMID:32655360
Endocrine Significance of SARS-CoV-2's Reliance on ACE2. PMID:32652001
Identification of the Combinatorial Effect of miRNA Family Regulatory Network in Different Growth Patterns of GC. PMID:32637572
A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily. PMID:32636308
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections. PMID:32628701
Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits. PMID:32628676
Targeted chromatin conformation analysis identifies novel distal neural enhancers of ZEB2 in pluripotent stem cell differentiation. PMID:32628253
Proteomic landscape of human coronary artery atherosclerosis. PMID:32626919
Coronavirus disease-19 and fertility: viral host entry protein expression in male and female reproductive tissues. PMID:32622411
Physiological blood-brain transport is impaired with age by a shift in transcytosis. PMID:32612231
Tyramide signal amplification mass spectrometry (TSA-MS) ratio identifies nuclear speckle proteins. PMID:32609799
A distinct talin2 structure directs isoform specificity in cell adhesion. PMID:32605925
BCALM (AC099524.1) Is a Human B Lymphocyte-Specific Long Noncoding RNA That Modulates B Cell Receptor-Mediated Calcium Signaling. PMID:32571842
A Sample Preparation Protocol for High Throughput Immunofluorescence of Suspension Cells on an Adherent Surface. PMID:32564662
Identification of immune and non-immune cells in regenerating axolotl limbs by single-cell sequencing. PMID:32562784
Mass Spectrometry-Based Discovery of in vitro Kinome Substrates. PMID:32547896
A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome. PMID:32521230
Downexpression of HSD17B6 correlates with clinical prognosis and tumor immune infiltrates in hepatocellular carcinoma. PMID:32514254
Low baseline pulmonary levels of cytotoxic lymphocytes as a predisposing risk factor for severe COVID-19. PMID:32511391
L1CAM High Expression Associates with Poor Prognosis in Glioma but Does Not Correlate with C11orf95-RELA Fusion. PMID:32509846
Tetraspanins in the regulation of mast cell function. PMID:32507938
Implications of antibody-dependent enhancement of infection for SARS-CoV-2 countermeasures. PMID:32504046
Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica. PMID:32503977
High-throughput, microscope-based sorting to dissect cellular heterogeneity. PMID:32500953
Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells. PMID:32492424
Tox21BodyMap: a webtool to map chemical effects on the human body. PMID:32491175
The role of 3'UTR-protein complexes in the regulation of protein multifunctionality and subcellular localization. PMID:32484544
Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation. PMID:32482897
Retrieval of germinal zone neural stem cells from the cerebrospinal fluid of premature infants with intraventricular hemorrhage. PMID:32475061
Endometrial profilin 1: a key player in embryo-endometrial crosstalk. PMID:32466630
Integration of Heterogeneous Experimental Data Improves Global Map of Human Protein Complexes. PMID:32457940
Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus. PMID:32447426
Comparative analysis of MACROD1, MACROD2 and TARG1 expression, localisation and interactome. PMID:32427867
Contact-ID, a tool for profiling organelle contact sites, reveals regulatory proteins of mitochondrial-associated membrane formation. PMID:32414919
Spatio-Temporal Roles of ASD-Associated Variants in Human Brain Development. PMID:32403330
The cell line A-to-I RNA editing catalogue. PMID:32383740
Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. PMID:32382484
ECMPride: prediction of human extracellular matrix proteins based on the ideal dataset using hybrid features with domain evidence. PMID:32377454
Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation. PMID:32376919
Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework. PMID:32355332
Comprehensive analysis of the SLC16A gene family in pancreatic cancer via integrated bioinformatics. PMID:32355273
Inferring spatial and signaling relationships between cells from single cell transcriptomic data. PMID:32350282
Organellar Maps Through Proteomic Profiling - A Conceptual Guide. PMID:32345598
Cell Atlas technologies and insights into tissue architecture. PMID:32339226
The Oncogenic Role of CENPA in Hepatocellular Carcinoma Development: Evidence from Bioinformatic Analysis. PMID:32337237
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression. PMID:32326089
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer. PMID:32322170
Direct trafficking pathways from the Golgi apparatus to the plasma membrane. PMID:32317144
Single-Molecule Super-Resolution Microscopy Reveals Heteromeric Complexes of MET and EGFR upon Ligand Activation. PMID:32316583
Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis. PMID:32311335
Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airways. PMID:32303635
A reference map of the human binary protein interactome. PMID:32296183
CSAG1 maintains the integrity of the mitotic centrosome in cells with defective p53. PMID:32295846
Nondestructive analysis of tumor-associated membrane protein MUC1 in living cells based on dual-terminal amplification of a DNA ternary complex. PMID:32292504
Inositol 1,4,5-Trisphosphate Receptors in Human Disease: A Comprehensive Update. PMID:32290556
Pooled Screens Identify GPR108 and TM9SF2 as Host Cell Factors Critical for AAV Transduction. PMID:32280726
Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling. PMID:32275659
The influence of ABCG2 polymorphism on erlotinib efflux in the K562 cell line. PMID:32266784
A Key mRNA-miRNA-lncRNA Competing Endogenous RNA Triple Sub-network Linked to Diagnosis and Prognosis of Hepatocellular Carcinoma. PMID:32257949
Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction. PMID:32251516
3D mesh processing using GAMer 2 to enable reaction-diffusion simulations in realistic cellular geometries. PMID:32251448
Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles. PMID:32245988
An in-silico human cell model reveals the influence of spatial organization on RNA splicing. PMID:32210422
Cellular processes involved in lung cancer cells exposed to direct current electric field. PMID:32210363
Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain. PMID:32198144
An array of 60,000 antibodies for proteome-scale antibody generation and target discovery. PMID:32195335
Exploring the HeLa Dark Mitochondrial Proteome. PMID:32195257
Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma. PMID:32194798
MARCKSL1 promotes the proliferation, migration and invasion of lung adenocarcinoma cells. PMID:32194726
Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. PMID:32193359
Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae. PMID:32182256
Monitoring protein communities and their responses to therapeutics. PMID:32139903
Control of Akt activity and substrate phosphorylation in cells. PMID:32125765
The microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates α-tubulin. PMID:32111740
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex. PMID:32111735
A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. PMID:32109415
Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells. PMID:32099016
Development and validation of a RNA binding protein-associated prognostic model for lung adenocarcinoma. PMID:32087603
The Relevance of Thimet Oligopeptidase in the Regulation of Energy Metabolism and Diet-Induced Obesity. PMID:32079362
[The role of interleukin-11 in osteosarcoma]. PMID:32078699
Comparison of Prostate-Specific Membrane Antigen Expression Levels in Human Salivary Glands to Non-Human Primates and Rodents. PMID:32074455
Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1. PMID:32071079
Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions. PMID:32061923
An isothermal shift assay for proteome scale drug-target identification. PMID:32060372
Restoration of MARCKS enhances chemosensitivity in cancer. PMID:32056006
CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes. PMID:32053779
The biology of ergothioneine, an antioxidant nutraceutical. PMID:32051057
Quantitative Proteomics to Identify Nuclear RNA-Binding Proteins of Malat1. PMID:32050583
The Progress of Multi-Omics Technologies: Determining Function in Lactic Acid Bacteria Using a Systems Level Approach. PMID:32047482
Classification of Trispanins: A Diverse Group of Proteins That Function in Membrane Synthesis and Transport Mechanisms. PMID:32039202
Protein disulfide isomerases are promising targets for predicting the survival and tumor progression in glioma patients. PMID:32023222
In silico approach to predict pancreatic β-cells classically secreted proteins. PMID:32003782
The omics revolution: beyond genomics. A meeting report. PMID:31997976
Microarray Analysis of Differential Gene Expression in Alzheimer's Disease Identifies Potential Biomarkers with Diagnostic Value. PMID:31984950
Biotin proximity tagging favours unfolded proteins and enables the study of intrinsically disordered regions. PMID:31969649
Polycystin 2 is increased in disease to protect against stress-induced cell death. PMID:31941974
IGF-1R inhibitor PQ401 inhibits osteosarcoma cell proliferation, migration and colony formation. PMID:31933976
The clinicopathological significance of decreased miR-125b-5p in hepatocellular carcinoma: evidence based on RT-qPCR, microRNA-microarray, and microRNA-sequencing. PMID:31933718
The TLK1/Nek1 axis contributes to mitochondrial integrity and apoptosis prevention via phosphorylation of VDAC1. PMID:31914854
Improved Single-Cell Proteome Coverage Using Narrow-Bore Packed NanoLC Columns and Ultrasensitive Mass Spectrometry. PMID:31913019
Circadian control of the secretory pathway maintains collagen homeostasis. PMID:31907414
MOCHI enables discovery of heterogeneous interactome modules in 3D nucleome. PMID:31907193
DDX3X Multifunctionally Modulates Tumor Progression and Serves as a Prognostic Indicator to Predict Cancer Outcomes. PMID:31906196
In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects. PMID:31903139
Profiling Cysteine Reactivity and Oxidation in the Endoplasmic Reticulum. PMID:31899610
Kynurenine, 3-OH-kynurenine, and anthranilate are nutrient metabolites that alter H3K4 trimethylation and H2AS40 O-GlcNAcylation at hypothalamus-related loci. PMID:31875008
High Levels of Glutaminase II Pathway Enzymes in Normal and Cancerous Prostate Suggest a Role in 'Glutamine Addiction'. PMID:31861280
Prolargin and matrix metalloproteinase-2 in heart failure after heart transplantation and their association with haemodynamics. PMID:31858729
TcellSubC: An Atlas of the Subcellular Proteome of Human T Cells. PMID:31849937
Proteomics: a powerful tool to study plant responses to biotic stress. PMID:31832077
Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD. PMID:31805375
A Combined Mass Spectrometry and Data Integration Approach to Predict the Mitochondrial Poly(A) RNA Interacting Proteome. PMID:31803741
Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples. PMID:31803426
Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans. PMID:31792237
The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data. PMID:31784565
miR-590-3p and Its Downstream Target Genes in HCC Cell Lines. PMID:31781476
Analysis of the Human Protein Atlas Image Classification competition. PMID:31780840
The great hairball gambit. PMID:31770365
Modeling population heterogeneity from microbial communities to immune response in cells. PMID:31768606
Regulation of small heat-shock proteins by hetero-oligomer formation. PMID:31767683
Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake. PMID:31757851
Is MYND Domain-Mediated Assembly of SMYD3 Complexes Involved in Calcium Dependent Signaling? PMID:31737645
Interferon-induced transmembrane proteins inhibit cell fusion mediated by trophoblast syncytins. PMID:31735710
Genetic variation in CFTR and modifier loci may modulate cystic fibrosis disease severity. PMID:31734115
Deep Profiling of Cellular Heterogeneity by Emerging Single-Cell Proteomic Technologies. PMID:31729152
Learning complex subcellular distribution patterns of proteins via analysis of immunohistochemistry images. PMID:31722369
System-based approaches as prognostic tools for glioblastoma. PMID:31718568
Fat cadherins in mouse models of degenerative ataxias. PMID:31695130
Co-regulation map of the human proteome enables identification of protein functions. PMID:31690884
Phase-separated condensates of metabolic complexes in living cells: Purinosome and glucosome. PMID:31668224
A Comparative Study of Target Engagement Assays for HDAC1 Inhibitor Profiling. PMID:31662025
MIC_Locator: a novel image-based protein subcellular location multi-label prediction model based on multi-scale monogenic signal representation and intensity encoding strategy. PMID:31655541
A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer. PMID:31640758
Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress. PMID:31625393
Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress. PMID:31591269
PhaSepDB: a database of liquid-liquid phase separation related proteins. PMID:31584089
Proteome Mapping of a Cyanobacterium Reveals Distinct Compartment Organization and Cell-Dispersed Metabolism. PMID:31578229
Coloring Cell Complexity: The Case for an Expansive Fluorophore Palette. PMID:31572774
Unbiased Thiol-Labeling and Top-Down Proteomic Analyses Implicate Multiple Proteins in the Late Steps of Regulated Secretion. PMID:31569819
JCPyV-Induced MAPK Signaling Activates Transcription Factors during Infection. PMID:31561471
Optical estimation of absolute membrane potential using fluorescence lifetime imaging. PMID:31545164
Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles. PMID:31544965
Discovery of high-confidence human protein-coding genes and exons by whole-genome PhyloCSF helps elucidate 118 GWAS loci. PMID:31537640
Evolution-based screening enables genome-wide prioritization and discovery of DNA repair genes. PMID:31501324
HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. PMID:31500569
The Spectrinome: The Interactome of a Scaffold Protein Creating Nuclear and Cytoplasmic Connectivity and Function. PMID:31483159
Learning unsupervised feature representations for single cell microscopy images with paired cell inpainting. PMID:31479439
Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme. PMID:31478652
DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases. PMID:31467668
EXTL3-interacting endometriosis-specific serum factors induce colony formation of endometrial stromal cells. PMID:31467315
Cell type- and tissue-specific functions of ecto-5'-nucleotidase (CD73). PMID:31461341
Progress on Identifying and Characterizing the Human Proteome: 2019 Metrics from the HUPO Human Proteome Project. PMID:31430157
Localization-specific distributions of protein pI in human proteome are governed by local pH and membrane charge. PMID:31429701
Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells. PMID:31428460
Deciphering GRINA/Lifeguard1: Nuclear Location, Ca2+ Homeostasis and Vesicle Transport. PMID:31426446
Stimulated upregulation of HO-1 is associated with inadequate response of gastric and ovarian cancer cell lines to hyperthermia and cisplatin treatment. PMID:31423266
The endosomal sorting adaptor HD-PTP is required for ephrin-B:EphB signalling in cellular collapse and spinal motor axon guidance. PMID:31420572
The proteome and its dynamics: A missing piece for integrative multi-omics in schizophrenia. PMID:31416743
Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus. PMID:31409686
The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification. PMID:31403225
Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome. PMID:31368359
Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome. PMID:31353912
The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. PMID:31328227
Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer. PMID:31324173
Benchmarking subcellular localization and variant tolerance predictors on membrane proteins. PMID:31307390
Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study. PMID:31277479
Integrating proteomics and transcriptomics for the identification of potential targets in early colorectal cancer. PMID:31268166
Separating Golgi Proteins from Cis to Trans Reveals Underlying Properties of Cisternal Localization. PMID:31266899
The Zebrafish Cytochrome b5/Cytochrome b5 Reductase/NADH System Efficiently Reduces Cytoglobins 1 and 2: Conserved Activity of Cytochrome b5/Cytochrome b5 Reductases during Vertebrate Evolution. PMID:31257865
Inferring Interaction Networks From Multi-Omics Data. PMID:31249591
Leveraging the Role of the Metastatic Associated Protein Anterior Gradient Homologue 2 in Unfolded Protein Degradation: A Novel Therapeutic Biomarker for Cancer. PMID:31247903
Biological Pathway Specificity in the Cell-Does Molecular Diversity Matter? PMID:31245864
Atlas of Subcellular RNA Localization Revealed by APEX-Seq. PMID:31230715
DeepMito: accurate prediction of protein sub-mitochondrial localization using convolutional neural networks. PMID:31218353
Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective. PMID:31216675
The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease. PMID:31214167
A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation. PMID:31172184
The Expanding Role of MT1-MMP in Cancer Progression. PMID:31137480
Deep learning for cellular image analysis. PMID:31133758
The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination. PMID:31127291
A Bioconductor workflow for the Bayesian analysis of spatial proteomics. PMID:31119032
Secretomes from metastatic breast cancer cells, enriched for a prognostically unfavorable LCN2 axis, induce anti-inflammatory MSC actions and a tumor-supportive premetastatic lung. PMID:31105883
Simultaneous Improvement in the Precision, Accuracy, and Robustness of Label-free Proteome Quantification by Optimizing Data Manipulation Chains. PMID:31097671
Dystrophin is expressed in smooth muscle and afferent nerve fibers in the rat urinary bladder. PMID:31095755
Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. PMID:31094706
Myg1 exonuclease couples the nuclear and mitochondrial translational programs through RNA processing. PMID:31081026
A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins. PMID:31078383
A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model. PMID:31061415
Prospective molecular mechanism of COL5A1 in breast cancer based on a microarray, RNA sequencing and immunohistochemistry. PMID:31059074
Redox-Dependent Loss of Flavin by Mitochondrial Complex I in Brain Ischemia/Reperfusion Injury. PMID:31037949
Altered Expression of DDR1 in Clear Cell Renal Cell Carcinoma Correlates With miR-199a/b-5p and Patients' Outcome. PMID:31018949
Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer. PMID:30999966
Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS. PMID:30970188
In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta. PMID:30958262
Proteomic studies of bone and skeletal health outcomes. PMID:30954730
Proximity-dependent proteomics of the Chlamydia trachomatis inclusion membrane reveals functional interactions with endoplasmic reticulum exit sites. PMID:30943267
BZW2 gene knockdown induces cell growth inhibition, G1 arrest and apoptosis in muscle-invasive bladder cancers: A microarray pathway analysis. PMID:30932331
Cell maps on the human genome. PMID:30930962
HMG CoA reductase expression as a prognostic factor in Korean patients with breast cancer: A retrospective study. PMID:30921201
Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications. PMID:30917677
Modulating protein-protein interaction networks in protein homeostasis. PMID:30913483
Targeting hormone refractory prostate cancer by in vivo selected DNA libraries in an orthotopic xenograft mouse model. PMID:30899039
Identification of Important Effector Proteins in the FOXJ1 Transcriptional Network Associated With Ciliogenesis and Ciliary Function. PMID:30881373
Cellular response to small molecules that selectively stall protein synthesis by the ribosome. PMID:30875366
Comprehensive analysis of the GATA transcription factor gene family in breast carcinoma using gene microarrays, online databases and integrated bioinformatics. PMID:30872657
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma. PMID:30872592
A novel Microproteomic Approach Using Laser Capture Microdissection to Study Cellular Protrusions. PMID:30866487
Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone. PMID:30855230
High Expression B3GAT3 Is Related with Poor Prognosis of Liver Cancer. PMID:30847403
Quantifying Tip60 (Kat5) stratifies breast cancer. PMID:30846725
Geometric characterisation of disease modules. PMID:30839777
Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation. PMID:30837475
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion. PMID:30836712
Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail. PMID:30818851
Integrated machine learning pipeline for aberrant biomarker enrichment (i-mAB): characterizing clusters of differentiation within a compendium of systemic lupus erythematosus patients. PMID:30815180
An integrative systems genetic analysis of mammalian lipid metabolism. PMID:30814737
Comprehensive clinical implications of homeobox A10 in 3,199 cases of non-small cell lung cancer tissue samples combining qRT-PCR, RNA sequencing and microarray data. PMID:30787969
Unsupervised identification of disease states from high-dimensional physiological and histopathological profiles. PMID:30782979
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues. PMID:30777892
Systems Biology Approaches Toward Understanding Primary Mitochondrial Diseases. PMID:30774647
Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring. PMID:30768568
Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila. PMID:30763317
The proteostasis network and its decline in ageing. PMID:30733602
Myosin Va interacts with the exosomal protein spermine synthase. PMID:30733278
Assessing sub-cellular resolution in spatial proteomics experiments. PMID:30711721
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules. PMID:30693281
Combining LOPIT with differential ultracentrifugation for high-resolution spatial proteomics. PMID:30659192
Comprehensive identification of RNA-protein interactions in any organism using orthogonal organic phase separation (OOPS). PMID:30607034
Cellular landmarks of Trypanosoma brucei and Leishmania mexicana. PMID:30550896
ALK expression favorably impacts the prognosis of NRAS-mutated metastatic melanomas. PMID:30546443
Antibody-Linked Fluorogen-Activating Proteins for Antigen Detection and Cell Ablation. PMID:30543409
Pre-mRNA modifications and their role in nuclear processing. PMID:30533247
Integrin Subunit beta 8 (ITGB8) Upregulation Is an Independent Predictor of Unfavorable Survival of High-Grade Serous Ovarian Carcinoma Patients. PMID:30531684
The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction. PMID:30530495
VIPER is a genetically encoded peptide tag for fluorescence and electron microscopy. PMID:30518560
The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes. PMID:30504233
The subcellular organisation of Saccharomyces cerevisiae. PMID:30503867
De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay. PMID:30500825
A Bayesian mixture modelling approach for spatial proteomics. PMID:30481170
Data-Independent Acquisition Mass Spectrometry To Quantify Protein Levels in FFPE Tumor Biopsies for Molecular Diagnostics. PMID:30481034
Proteomics of nucleocytoplasmic partitioning. PMID:30472625
MitoMiner v4.0: an updated database of mitochondrial localization evidence, phenotypes and diseases. PMID:30398659
Solute Carrier Family 27 Member 4 (SLC27A4) Enhances Cell Growth, Migration, and Invasion in Breast Cancer Cells. PMID:30388870
Translocatome: a novel resource for the analysis of protein translocation between cellular organelles. PMID:30380112
The in silico human surfaceome. PMID:30373828
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. PMID:30367059
Specific Modification of Aged Proteasomes Revealed by Tag-Exchangeable Knock-In Mice. PMID:30348842
Location is everything: protein translocations as a viral infection strategy. PMID:30339987
GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking. PMID:30333138
Clinical efficacy of sublingual immunotherapy is associated with restoration of steady-state serum lipocalin 2 after SLIT: a pilot study. PMID:30323863
Screening of candidate substrates and coupling ions of transporters by thermostability shift assays. PMID:30320551
The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease. PMID:30319631
Understanding molecular mechanisms of disease through spatial proteomics. PMID:30308467
LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway. PMID:30301939
The combination of everolimus and terameprocol exerts synergistic antiproliferative effects in endometrial cancer: molecular role of insulin-like growth factor binding protein 2. PMID:30298385
Autoantibodies Against Perilipin 1 as a Cause of Acquired Generalized Lipodystrophy. PMID:30283460
A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles. PMID:30266947
A recap of RNA recapping. PMID:30252202
A meta-analysis and bioinformatics exploration of the diagnostic value and molecular mechanism of miR-193a-5p in lung cancer. PMID:30250529
Vimentin Diversity in Health and Disease. PMID:30248895
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome. PMID:30242179
Cell-Permeable Activity-Based Ubiquitin Probes Enable Intracellular Profiling of Human Deubiquitinases. PMID:30240200
Targeted Analysis of Lysosomal Directed Proteins and Their Sites of Mannose-6-phosphate Modification. PMID:30237200
Selective Forces Related to Spinocerebellar Ataxia Type 2. PMID:30219976
RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome. PMID:30166341
Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1. PMID:30159402
Region-Resolved Quantitative Proteome Profiling Reveals Molecular Dynamics Associated With Chronic Pain in the PNS and Spinal Cord. PMID:30154697
Transfer RNA genes experience exceptionally elevated mutation rates. PMID:30127029
Efficient proximity labeling in living cells and organisms with TurboID. PMID:30125270
Deep learning is combined with massive-scale citizen science to improve large-scale image classification. PMID:30125267
Analysis of eIF2B bodies and their relationships with stress granules and P-bodies. PMID:30115954
Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project. PMID:30099871
Prognostic values of the inhibitor of DNA‑binding family members in breast cancer. PMID:30066902
Pan-Cancer Analysis Reveals the Functional Importance of Protein Lysine Modification in Cancer Development. PMID:30065750
Quanti.us: a tool for rapid, flexible, crowd-based annotation of images. PMID:30065368
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. PMID:30053424
Identification of integrin drug targets for 17 solid tumor types. PMID:30046394
Mapping the Genetic Landscape of Human Cells. PMID:30033366
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. PMID:30021884
Quantifying compartment-associated variations of protein abundance in proteomics data. PMID:29967062
Six novel susceptibility loci for coronary artery disease and cerebral infarction identified by longitudinal exome-wide association studies in a Japanese population. PMID:29963304
Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins. PMID:29954413
The Effect of GPRC5a on the Proliferation, Migration Ability, Chemotherapy Resistance, and Phosphorylation of GSK-3β in Pancreatic Cancer. PMID:29949874
Resolution Matters: Correlating Quantitative Proteomics and Nanoscale-Precision Microscopy for Reconstructing Synapse Identity. PMID:29932496
Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases. PMID:29926844
A Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease. PMID:29924966
Prediction of subcellular location of apoptosis proteins by incorporating PsePSSM and DCCA coefficient based on LFDA dimensionality reduction. PMID:29914358
Chromatin Succinylation Correlates with Active Gene Expression and Is Perturbed by Defective TCA Cycle Metabolism. PMID:29888767
From Atoms to Cells: Using Mesoscale Landscapes to Construct Visual Narratives. PMID:29885327
Upregulation of KIF26B, Cell Migration and Proliferation of Human Ovarian Cancer Cell Lines In Vitro, and Patient Outcomes from Human Bioinformatic Analysis. PMID:29880787
Comparison of tumor related signaling pathways with known compounds to determine potential agents for lung adenocarcinoma. PMID:29870138
KIAA0100 Modulates Cancer Cell Aggression Behavior of MDA-MB-231 through Microtubule and Heat Shock Proteins. PMID:29867023
Severe neurocognitive and growth disorders due to variation in THOC2, an essential component of nuclear mRNA export machinery. PMID:29851191
Toward Small-Molecule Inhibition of Protein-Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions. PMID:29848279
The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones. PMID:29844425
Casein kinase 1α: biological mechanisms and theranostic potential. PMID:29793495
Genetic identification of brain cell types underlying schizophrenia. PMID:29785013
Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens. PMID:29778836
Redistribution of SERCA calcium pump conformers during intracellular calcium signaling. PMID:29764938
Correcting mistakes in predicting distributions. PMID:29762646
Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates. PMID:29752409
Transcellular transport of cobalamin in aortic endothelial cells. PMID:29741927
Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells. PMID:29729928
The tale of two talins - two isoforms to fine-tune integrin signalling. PMID:29723415
Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription. PMID:29712969
Pervasive Protein Thermal Stability Variation during the Cell Cycle. PMID:29706546
An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein. PMID:29638216
The latent geometry of the human protein interaction network. PMID:29635317
Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins. PMID:29620521
Peptide Sharing Between Viruses and DLX Proteins: A Potential Cross-Reactivity Pathway to Neuropsychiatric Disorders. PMID:29618965
HLA-G peptide preferences change in transformed cells: impact on the binding motif. PMID:29602958
The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair. PMID:29599527
A Structured Workflow for Mapping Human Sin3 Histone Deacetylase Complex Interactions Using Halo-MudPIT Affinity-Purification Mass Spectrometry. PMID:29599190
Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic β Cell. PMID:29570991
ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease. PMID:29556082
Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs. PMID:29539586
The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis. PMID:29515971
Mapping of Human FOXP2 Enhancers Reveals Complex Regulation. PMID:29515369
Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism. PMID:29514978
Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides. PMID:29514240
The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein. PMID:29499066
Carbonic Anhydrases: Role in pH Control and Cancer. PMID:29495652
Unique Phenotypic Characteristics of Recently Transmitted HIV-1 Subtype C Envelope Glycoprotein gp120: Use of CXCR6 Coreceptor by Transmitted Founder Viruses. PMID:29491151
GCN5L1/BLOS1 Links Acetylation, Organelle Remodeling, and Metabolism. PMID:29477615
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. PMID:29472497
Adhesion GPCRs in Kidney Development and Disease. PMID:29468160
An in silico argument for mitochondrial microRNA as a determinant of primary non function in liver transplantation. PMID:29449571
The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy. PMID:29445380
Role of Protein Phosphatase 1 and Inhibitor of Protein Phosphatase 1 in Nitric Oxide-Dependent Inhibition of the DNA Damage Response in Pancreatic β-Cells. PMID:29444892
Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number. PMID:29444442
Human expression patterns: qualitative and quantitative analysis of thrombospondin-1 under physiological and pathological conditions. PMID:29441713
Fatty acid-binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation. PMID:29440395
GeneGini: Assessment via the Gini Coefficient of Reference "Housekeeping" Genes and Diverse Human Transporter Expression Profiles. PMID:29428416
Peptide Level Turnover Measurements Enable the Study of Proteoform Dynamics. PMID:29414762
ABCA7 and Pathogenic Pathways of Alzheimer's Disease. PMID:29401741
Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology. PMID:29350411
Spatiotemporal allele organization by allele-specific CRISPR live-cell imaging (SNP-CLING). PMID:29343869
Stat3-mediated alterations in lysosomal membrane protein composition. PMID:29343516
Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients. PMID:29309586
Accurate prediction of subcellular location of apoptosis proteins combining Chou's PseAAC and PsePSSM based on wavelet denoising. PMID:29296195
Using single-cell multiple omics approaches to resolve tumor heterogeneity. PMID:29285690
The Human Cell Atlas. PMID:29206104
The OncoPPi Portal: an integrative resource to explore and prioritize protein-protein interactions for cancer target discovery. PMID:29186335
Interaction profiling of RNA-binding ubiquitin ligases reveals a link between posttranscriptional regulation and the ubiquitin system. PMID:29185492
Three-dimensional imaging reveals endo(sarco)plasmic reticulum-containing invaginations within the nucleoplasm of muscle. PMID:29167149
A Role of Sp1 Binding Motifs in Basal and Large T-Antigen-Induced Promoter Activities of Human Polyomavirus HPyV9 and Its Variant UF-1. PMID:29135936
Region and cell-type resolved quantitative proteomic map of the human heart. PMID:29133944
Electrophoretic cytometry of adherent cells. PMID:29120467
NLSdb-major update for database of nuclear localization signals and nuclear export signals. PMID:29106588
Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase. PMID:29104065
High SLC4A11 expression is an independent predictor for poor overall survival in grade 3/4 serous ovarian cancer. PMID:29091960
Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells. PMID:29089484
Framework and resource for more than 11,000 gene-transcript-protein-reaction associations in human metabolism. PMID:29078384
TCSBN: a database of tissue and cancer specific biological networks. PMID:29069445
Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging. PMID:29051264
Chronic β2 -adrenoceptor agonist treatment alters muscle proteome and functional adaptations induced by high intensity training in young men. PMID:28983994
RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs. PMID:28981715
The human protein atlas: A spatial map of the human proteome. PMID:28940711
Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project. PMID:28853897
Network analyses identify liver-specific targets for treating liver diseases. PMID:28827398
New Challenges to Study Heterogeneity in Cancer Redox Metabolism. PMID:28744456
Aspirin Prevention of Colorectal Cancer: Focus on NF-κB Signalling and the Nucleolus. PMID:28718829 -
A human protein atlas for normal and cancer tissues based on antibody proteomics
PubMed citations: 577.
577 articles citing: A human protein atlas for normal and cancer tissues based on antibody proteomics
Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature. PMID:35907972
Role of Glycolysis/Gluconeogenesis and HIF-1 Signaling Pathways in Rats with Dental Fluorosis Integrated Proteomics and Metabolomics Analysis. PMID:35897842
Biodistribution and Cellular Internalization of Inactivated SARS-CoV-2 in Wild-Type Mice. PMID:35886958
Integrated Bioinformatics Analysis of the Hub Genes Involved in Irinotecan Resistance in Colorectal Cancer. PMID:35885025
Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7. PMID:35867177
Potentiality of Exosomal Proteins as Novel Cancer Biomarkers for Liquid Biopsy. PMID:35757760
Metabolomic Analysis Points to Bioactive Lipid Species and Acireductone Dioxygenase 1 (ADI1) as Potential Therapeutic Targets in Poor Prognosis Endometrial Cancer. PMID:35740505
The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated. PMID:35681770
The Ramp Atlas: facilitating tissue and cell-specific ramp sequence analyses through an intuitive web interface. PMID:35664804
Modulation of Tumor Immune Microenvironment and Prognostic Value of Ferroptosis-Related Genes, and Candidate Target Drugs in Glioblastoma Multiforme. PMID:35571123
Identification of Candidate Genes Regulating Carcass Depth and Hind Leg Circumference in Simmental Beef Cattle Using Illumina Bovine Beadchip and Next-Generation Sequencing Analyses. PMID:35565529
Updated Functional Roles of NAMPT in Carcinogenesis and Therapeutic Niches. PMID:35565188
NIBAN1, Exploring its Roles in Cell Survival Under Stress Context. PMID:35517496
Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer. PMID:35508649
Functional and pathologic association of aminoacyl-tRNA synthetases with cancer. PMID:35501376
Targeting TNFR2: A Novel Breakthrough in the Treatment of Cancer. PMID:35494080
NUSAP1 Could be a Potential Target for Preventing NAFLD Progression to Liver Cancer. PMID:35431924
RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression. PMID:35428760
Proteomic-Based Machine Learning Analysis Reveals PYGB as a Novel Immunohistochemical Biomarker to Distinguish Inverted Urothelial Papilloma From Low-Grade Papillary Urothelial Carcinoma With Inverted Growth. PMID:35402263
What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy? PMID:35388168
The yellow brick road to nuclear membrane mechanotransduction. PMID:35382443
Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach. PMID:35339898
CHST4 might promote the malignancy of cholangiocarcinoma. PMID:35294478
Cytosolic O-GlcNAcylation and PNG1 maintain Drosophila gut homeostasis by regulating proliferation and apoptosis. PMID:35294432
Plasma Protein Levels Analysis in Multiple Sclerosis Sardinian Families Identified C9 and CYP24A1 as Candidate Biomarkers. PMID:35207439
Identification of Tissue-Specific Gene Clusters Induced by DNA Demethylation in Lung Adenocarcinoma: More Than Germline Genes. PMID:35205751
Loss of MAGEC3 Expression Is Associated with Prognosis in Advanced Ovarian Cancers. PMID:35158998
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study. PMID:35106505
Mendelian randomization analyses implicate biogenesis of translation machinery in human aging. PMID:35078808
Syndecan-4 Is a Key Facilitator of the SARS-CoV-2 Delta Variant's Superior Transmission. PMID:35054983
Comprehensive Analysis of the Prognostic Values of the TRIM Family in Hepatocellular Carcinoma. PMID:35004288
As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma. PMID:35002505
Reduction of Rapid Proliferating Tumour Cell Lines by Inhibition of the Specific Glycine Transporter GLYT1. PMID:34944586
Subcellular Transcriptomics and Proteomics: A Comparative Methods Review. PMID:34922010
Anti-Tumor Necrosis Factor Receptor 2 Antibody Combined With Anti-PD-L1 Therapy Exerts Robust Antitumor Effects in Breast Cancer. PMID:34900985
Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics. PMID:34900668
GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus. PMID:34893534
Comprehensive Analysis of REST/NRSF Gene in Glioma and Its ceRNA Network Identification. PMID:34859007
Gossypol Treatment Restores Insufficient Apoptotic Function of DFF40/CAD in Human Glioblastoma Cells. PMID:34771741
DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell Biology and Human Diseases. PMID:34768967
Prognostic biomarkers for predicting papillary thyroid carcinoma patients at high risk using nine genes of apoptotic pathway. PMID:34767591
Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle. PMID:34752468
SPTBN2, a New Biomarker of Lung Adenocarcinoma. PMID:34745988
The TNF-α/TNFR2 Pathway: Targeting a Brake to Release the Anti-tumor Immune Response. PMID:34712661
Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas. PMID:34680577
Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma. PMID:34621750
Multiomics-based analyses of KPNA2 highlight its multiple potentials in hepatocellular carcinoma. PMID:34616632
RUNX2 and LAMC2: promising pancreatic cancer biomarkers identified by an integrative data mining of pancreatic adenocarcinoma tissues. PMID:34606473
Dermal Olfactory Receptor OR51B5 Is Essential for Survival and Collagen Synthesis in Human Dermal Fibroblast (Hs68 Cells). PMID:34502185
A 14-Marker Multiplexed Imaging Panel for Prognostic Biomarkers and Tumor Heterogeneity in Head and Neck Squamous Cell Carcinoma. PMID:34490110
GSK2126458 has the potential to inhibit the proliferation of pancreatic cancer uncovered by bioinformatics analysis and pharmacological experiments. PMID:34461940
Survival-Based Biomarker Module Identification Associated with Oral Squamous Cell Carcinoma (OSCC). PMID:34439992
Investigation of Anti-Tumor Effects of an MLK1 Inhibitor in Prostate and Pancreatic Cancers. PMID:34439974
A ChIP-exo screen of 887 Protein Capture Reagents Program transcription factor antibodies in human cells. PMID:34426512
High Matrix Metalloproteinase 28 Expression is Associated with Poor Prognosis in Pancreatic Adenocarcinoma. PMID:34408436
A proteogenomic portrait of lung squamous cell carcinoma. PMID:34358469
Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice. PMID:34340748
CDK10 in Gastrointestinal Cancers: Dual Roles as a Tumor Suppressor and Oncogene. PMID:34277407
Identification of an EMT-Related Gene Signature for Predicting Overall Survival in Gastric Cancer. PMID:34249086
Components and Mechanisms of Nuclear Mechanotransduction. PMID:34213953
Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study. PMID:34151794
KDF1, a Novel Tumor Suppressor in Clear Cell Renal Cell Carcinoma. PMID:34136411
Making fundamental scientific discoveries by combining information from literature, databases, and computational tools - An example. PMID:34136100
Expression of Parkin, APC, APE1, and Bcl-xL in Colorectal Polyps. PMID:34126796
Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma. PMID:34115569
In-Silico Evaluation of Genetic Alterations in Ovarian Carcinoma and Therapeutic Efficacy of NSC777201, as a Novel Multi-Target Agent for TTK, NEK2, and CDK1. PMID:34072728
Impact of histological response after neoadjuvant therapy on podocalyxin as a prognostic marker in pancreatic cancer. PMID:33972616
Hypoxia Constructing the Prognostic Model of Colorectal Adenocarcinoma and Related to the Immune Microenvironment. PMID:33959617
Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches. PMID:33925358
Generation of a Polyclonal Antibody against the Mouse Metal Transporter ZIP8. PMID:33919173
Functional Roles of SPINK1 in Cancers. PMID:33916984
Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11. PMID:33901943
Identification of Basp1 as a novel angiogenesis-regulating gene by multi-model system studies. PMID:33899275
Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli. PMID:33893305
SLC39A8/Zinc Suppresses the Progression of Clear Cell Renal Cell Carcinoma. PMID:33869056
Integrative Pan-Cancer Analysis Reveals Decreased Melatonergic Gene Expression in Carcinogenesis and RORA as a Prognostic Marker for Hepatocellular Carcinoma. PMID:33842355
Proteomic comparison between different tissue preservation methods for identification of promising biomarkers of urothelial bladder cancer. PMID:33828141
The Association between TIF1 Family Members and Cancer Stemness in Solid Tumors. PMID:33810347
Leptin Is Associated with Poor Clinical Outcomes and Promotes Clear Cell Renal Cell Carcinoma Progression. PMID:33804101
Combined De-Repression of Chemoresistance Associated Mitogen-Activated Protein Kinase 14 and Activating Transcription Factor 2 by Loss of microRNA-622 in Hepatocellular Carcinoma. PMID:33803354
Leptin and Cancer: Updated Functional Roles in Carcinogenesis, Therapeutic Niches, and Developments. PMID:33799880
Integrated analysis of RNA-binding proteins in thyroid cancer. PMID:33711033
Tie-2, G-CSF, and Leptin as Promising Diagnostic Biomarkers for Endometrial Cancer: A Pilot Study. PMID:33671851
Colloidal Stability and Cytotoxicity of Polydopamine-Conjugated Gold Nanorods against Prostate Cancer Cell Lines. PMID:33670890
Key Enzymes in Pyrimidine Synthesis, CAD and CPS1, Predict Prognosis in Hepatocellular Carcinoma. PMID:33670206
Suppression of ELF4 in ulcerative colitis predisposes host to colorectal cancer. PMID:33665583
Reflections on the HUPO Human Proteome Project, the Flagship Project of the Human Proteome Organization, at 10 Years. PMID:33640492
The doxorubicin-induced cell motility network is under the control of the ceramide-activated protein phosphatase 1 alpha. PMID:33583073
CLIP4 Shows Putative Tumor Suppressor Characteristics in Breast Cancer: An Integrated Analysis. PMID:33575272
SWATH-MS Based Proteomic Profiling of Prostate Cancer Cells Reveals Adaptive Molecular Mechanisms in Response to Anti-Androgen Therapy. PMID:33572476
Harnessing Tumor Necrosis Factor Alpha to Achieve Effective Cancer Immunotherapy. PMID:33540543
TNF-TNFR2 Signal Plays a Decisive Role in the Activation of CD4+Foxp3+ Regulatory T Cells: Implications in the Treatment of Autoimmune Diseases and Cancer. PMID:33523452
Expression and gene regulatory network of SNHG1 in hepatocellular carcinoma. PMID:33499863
Thalidomide and its metabolite 5-hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF. PMID:33470442
GATA3 somatic mutations are associated with clinicopathological features and expression profile in TCGA breast cancer patients. PMID:33462316
Multiple microarray analyses identify key genes associated with the development of Non-Small Cell Lung Cancer from Chronic Obstructive Pulmonary Disease. PMID:33442399
PLZF and PLZF-MAPK10 can predict the prognosis of postoperative patients with hepatocellular carcinoma. PMID:33425116
Intracellular leucine-rich alpha-2-glycoprotein-1 competes with Apaf-1 for binding cytochrome c in protecting MCF-7 breast cancer cells from apoptosis. PMID:33386492
Decreasing the Susceptibility of Malignant Cells to Infection Does Not Impact the Overall Efficacy of Myxoma Virus-Based Oncolytic Virotherapy. PMID:33335977
Multi-Omics Database Analysis of Aminoacyl-tRNA Synthetases in Cancer. PMID:33266490
Synthesis, Kinetic and Conformational Studies of 2-Substituted-5-(β-d-glucopyranosyl)-pyrimidin-4-ones as Potential Inhibitors of Glycogen Phosphorylase. PMID:33266408
BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage. PMID:33236795
Downstream Neighbor of SON (DONSON) Expression Is Enhanced in Phenotypically Aggressive Prostate Cancers. PMID:33228112
Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment. PMID:33194695
MicroRNA-1269a Promotes Proliferation and Arrest of Apoptosis of Glioma Cells by Directly Targeting ATRX. PMID:33194637
Potential SARS-CoV-2 interactions with proteins involved in trophoblast functions - An in-silico study. PMID:33126048
SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer. PMID:33122723
Silencing of sinusoidal DDR1 reduces murine liver metastasis by colon carcinoma. PMID:33110221
Novel deletion mutations of the PIH1D3 gene in an infertile young man with primary ciliary dyskinesia and his cousin with Kartagener's syndrome. PMID:33106461
A high-stringency blueprint of the human proteome. PMID:33067450
Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis. PMID:33050659
Total Matrix Ca2+ Modulates Ca2+ Efflux via the Ca2+/H+ Exchanger in Cardiac Mitochondria. PMID:33041851
Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer. PMID:33030783
Prognostic Score-based Clinical Factors and Metabolism-related Biomarkers for Predicting the Progression of Hepatocellular Carcinoma. PMID:33013158
Annexin A7 Regulates Endometrial Receptivity. PMID:32923441
Integrated PPI- and WGCNA-Retrieval of Hub Gene Signatures Shared Between Barrett's Esophagus and Esophageal Adenocarcinoma. PMID:32903837
Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish. PMID:32868902
DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas. PMID:32838940
Zooming into the Dark Side of Human Annexin-S100 Complexes: Dynamic Alliance of Flexible Partners. PMID:32824294
Combining Gene-Disease Associations with Single-Cell Gene Expression Data Provides Anatomy-Specific Subnetworks in Age-Related Macular Degeneration. PMID:32789304
A Microdosing Study with 99mTc-PHC-102 for the SPECT/CT Imaging of Primary and Metastatic Lesions in Renal Cell Carcinoma Patients. PMID:32680925
Integrated analysis of optical mapping and whole-genome sequencing reveals intratumoral genetic heterogeneity in metastatic lung squamous cell carcinoma. PMID:32676329
A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells. PMID:32669955
Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells. PMID:32664515
Intellectual Disability and Potassium Channelopathies: A Systematic Review. PMID:32655623
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma. PMID:32649874
MicroRNAs as Guardians of the Prostate: Those Who Stand before Cancer. What Do We Really Know about the Role of microRNAs in Prostate Biology? PMID:32645914
Prognostic role of immune cells in hepatocellular carcinoma. PMID:32636725
Morphological Profiling Identifies a Common Mode of Action for Small Molecules with Different Targets. PMID:32618075
Expression and prognosis analysis of DNMT family in acute myeloid leukemia. PMID:32597790
Analysis of Expression and Its Clinical Significance of the Secreted Phosphoprotein 1 in Lung Adenocarcinoma. PMID:32595698
Characterization of RNA-Binding Motif 3 (RBM3) Protein Levels and Nuclear Architecture Changes in Aggressive and Recurrent Prostate Cancer. PMID:32587951
Maspin as a Prognostic Marker for Early Stage Colorectal Cancer With Microsatellite Instability. PMID:32587829
Identification of Cell-Surface Proteins Endocytosed by Human Brain Microvascular Endothelial Cells In Vitro. PMID:32585920
Regulation of cellular senescence by eukaryotic members of the FAH superfamily - A role in calcium homeostasis? PMID:32574647
NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways. PMID:32559195
Estrogen Formation and Inactivation Following TBI: What we Know and Where we Could go. PMID:32547495
Met-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations. PMID:32533056
BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27. PMID:32517789
Sub-zeptomole Detection of Biomarker Proteins Using a Microfluidic Immunoarray with Nanostructured Sensors. PMID:32433882
Comprehensive transcriptomic analysis identifies novel regulators of lung adenocarcinoma. PMID:32415511
Grainyhead-Like Genes Family May Act as Novel Biomarkers in Colon Cancer. PMID:32368082
Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance. PMID:32345725
Cell Atlas technologies and insights into tissue architecture. PMID:32339226
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression. PMID:32326089
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer. PMID:32322170
PTHrP, A Biomarker for CNS Metastasis in Triple-Negative Breast Cancer and Selection for Adjuvant Chemotherapy in Node-Negative Disease. PMID:32296756
Prognostic value of increased expression of RBM8A in gastric cancer. PMID:32294703
Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor. PMID:32293552
Molecular Targets for Combined Therapeutic Strategies to Limit Glioblastoma Cell Migration and Invasion. PMID:32292341
Considerations for Using the Vasculature as a Coordinate System to Map All the Cells in the Human Body. PMID:32232057
TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration. PMID:32228863
OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine. PMID:32210335
Expression and prognosis analysis of TET family in acute myeloid leukemia. PMID:32209730
FKBP4 is a malignant indicator in luminal A subtype of breast cancer. PMID:32194784
Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. PMID:32193359
Membrane mucins of the intestine at a glance. PMID:32169835
Prolyl 4-hydroxylase alpha 1 protein expression risk-stratifies early stage colorectal cancer. PMID:32166002
Validation of Novel Prognostic Biomarkers for Early-Stage Clear-Cell, Endometrioid and Mucinous Ovarian Carcinomas Using Immunohistochemistry. PMID:32133296
Control of tissue morphogenesis by the HOX gene Ultrabithorax. PMID:32122911
Small Molecule Binds with Lymphocyte Antigen 6K to Induce Cancer Cell Death. PMID:32098321
Peripheral-to-central immune communication at the area postrema glial-barrier following bleomycin-induced sterile lung injury in adult rats. PMID:32097765
New technologies to analyse protein function: an intrinsic disorder perspective. PMID:32089835
Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D. PMID:32082316
Mutual Regulation of RNA Silencing and the IFN Response as an Antiviral Defense System in Mammalian Cells. PMID:32079277
HMI-PRED: A Web Server for Structural Prediction of Host-Microbe Interactions Based on Interface Mimicry. PMID:32061934
SurfaceGenie: a web-based application for prioritizing cell-type-specific marker candidates. PMID:32053146
Limited utility of qPCR-based detection of tumor-specific circulating mRNAs in whole blood from clear cell renal cell carcinoma patients. PMID:32013938
PDAC-ANN: an artificial neural network to predict pancreatic ductal adenocarcinoma based on gene expression. PMID:32005189
Utility of primary cells to examine NPC1 receptor expression in Mops condylurus, a potential Ebola virus reservoir. PMID:31961874
Tripartite factors leading to molecular divergence between human and murine smooth muscle. PMID:31945134
Sorafenib Inhibits Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in Hepatocellular Carcinoma Cells. PMID:31936661
Inflammasome expression is higher in ovarian tumors than in normal ovary. PMID:31923221
Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association. PMID:31911620
DDX3X Multifunctionally Modulates Tumor Progression and Serves as a Prognostic Indicator to Predict Cancer Outcomes. PMID:31906196
RAB6C is an independent prognostic factor of estrogen receptor-positive/progesterone receptor-negative breast cancer. PMID:31897114
Spatially multiplexed RNA in situ hybridization to reveal tumor heterogeneity. PMID:31853536
Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry. PMID:31826992
Clinical roles of miR-136-5p and its target metadherin in thyroid carcinoma. PMID:31814886
Oncoviruses Can Drive Cancer by Rewiring Signaling Pathways Through Interface Mimicry. PMID:31803618
Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants. PMID:31750562
Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis. PMID:31748414
Integrative proteomic and phosphoproteomic profiling of prostate cell lines. PMID:31675377
Downregulation of GRK5 hampers the migration of breast cancer cells. PMID:31664083
Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis. PMID:31602402
Multiplexed analysis of the secretin-like GPCR-RAMP interactome. PMID:31555726
Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian carcinomas. PMID:31533654
Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells. PMID:31523390
HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. PMID:31500569
DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases. PMID:31467668
Multi-functionality of proteins involved in GPCR and G protein signaling: making sense of structure-function continuum with intrinsic disorder-based proteoforms. PMID:31428838
Th17 Cells in Helicobacter pylori Infection: a Dichotomy of Help and Harm. PMID:31427446
Secretome profiling of PC3/nKR cells, a novel highly migrating prostate cancer subline derived from PC3 cells. PMID:31404090
Exploring the Extracellular Regulation of the Tumor Angiogenic Interaction Network Using a Systems Biology Model. PMID:31379588
Directed evolution as a tool for the selection of oncolytic RNA viruses with desired phenotypes. PMID:31372363
Circulating CASK is associated with recurrent focal segmental glomerulosclerosis after transplantation. PMID:31356645
L1TD1 - a prognostic marker for colon cancer. PMID:31337362
Anticancer Immunotherapy by MFAP5 Blockade Inhibits Fibrosis and Enhances Chemosensitivity in Ovarian and Pancreatic Cancer. PMID:31332047
Benchmarking subcellular localization and variant tolerance predictors on membrane proteins. PMID:31307390
Genome-wide functional association networks: background, data & state-of-the-art resources. PMID:31281921
Gold nanoparticles stabilized with four kinds of amino acid-derived carbon dots for colorimetric and visual discrimination of proteins and microorganisms. PMID:31280372
Comparison of Human Tissue Microarray to Human Pericyte Transcriptome Yields Novel Perivascular Cell Markers. PMID:31264500
Dissecting the expression landscape of cytochromes P450 in hepatocellular carcinoma: towards novel molecular biomarkers. PMID:31258835
Identification of CTRP1 as a Prognostic Biomarker and Oncogene in Human Glioblastoma. PMID:31183364
A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation. PMID:31172184
Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients. PMID:31156624
Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma. PMID:31154438
Plasma protein profiling reveals candidate biomarkers for multiple sclerosis treatment. PMID:31141529
The Structural and Functional Diversity of Intrinsically Disordered Regions in Transmembrane Proteins. PMID:31139867
Usefulness of gene expression profiling of bronchoalveolar lavage cells in acute lung allograft rejection. PMID:31122726
ZNF277 regulates ovarian cancer cell proliferation and invasion through inhibition of PTEN. PMID:31114246
Expression profile and functional role of S100A14 in human cancer. PMID:31105881
Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling. PMID:31087223
TRPV2 Calcium Channel Gene Expression and Outcomes in Gastric Cancer Patients: A Clinically Relevant Association. PMID:31083561
STAT6 knockdown using multiple siRNA sequences inhibits proliferation and induces apoptosis of human colorectal and breast cancer cell lines. PMID:31075146
Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells. PMID:31068932
Network Medicine in the Age of Biomedical Big Data. PMID:31031797
Systems Biology Reveals NR2F6 and TGFB1 as Key Regulators of Feed Efficiency in Beef Cattle. PMID:30967894
Interleukin 32 expression in human melanoma. PMID:30953519
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion. PMID:30836712
Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail. PMID:30818851
MTA2-mediated inhibition of PTEN leads to pancreatic ductal adenocarcinoma carcinogenicity. PMID:30814496
If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease. PMID:30775245
Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability. PMID:30735487
The novel sugar transporter SLC50A1 as a potential serum-based diagnostic and prognostic biomarker for breast cancer. PMID:30697078
Carbonic Anhydrase 6 Gene Variation influences Oral Microbiota Composition and Caries Risk in Swedish adolescents. PMID:30679524
Unique roles of tryptophanyl-tRNA synthetase in immune control and its therapeutic implications. PMID:30613102
ErbB2-driven downregulation of the transcription factor Irf6 in breast epithelial cells is required for their 3D growth. PMID:30545388
Loss of Ca2+/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease. PMID:30525042
Chemical Biology of Protein N-Terminal Methyltransferases. PMID:30479015
Open Targets Platform: new developments and updates two years on. PMID:30462303
Stress and interferon signalling-mediated apoptosis contributes to pleiotropic anticancer responses induced by targeting NGLY1. PMID:30385822
Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome. PMID:30356161
Interface-Based Structural Prediction of Novel Host-Pathogen Interactions. PMID:30298406
Impact of chemotactic factors and receptors on the cancer immune infiltrate: a bioinformatics study revealing homogeneity and heterogeneity among patient cohorts. PMID:30288345
High RNA-binding Motif Protein 3 Expression Is Associated with Improved Clinical Outcomes in Invasive Breast Cancer. PMID:30275857
A Computational Method for Classifying Different Human Tissues with Quantitatively Tissue-Specific Expressed Genes. PMID:30205473
Targeting the Multidrug Transporter Ptch1 Potentiates Chemotherapy Efficiency. PMID:30110910
A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction. PMID:30097758
Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma. PMID:30072578
Frequent CLDN18-ARHGAP fusion in highly metastatic diffuse-type gastric cancer with relatively early onset. PMID:30034621
A pilot study to profile salivary angiogenic factors to detect head and neck cancers. PMID:30001714
Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons. PMID:29997469
Expression of periaxin (PRX) specifically in the human cerebrovascular system: PDZ domain-mediated strengthening of endothelial barrier function. PMID:29968755
Autocrine Fibronectin Inhibits Breast Cancer Metastasis. PMID:29934326
Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality. PMID:29888466
Papillomavirus E2 protein is regulated by specific fibroblast growth factor receptors. PMID:29885490
Precision histology: how deep learning is poised to revitalize histomorphology for personalized cancer care. PMID:29872706
Analysis of the effect of promoter type and skin pretreatment on antigen expression and antibody response after gene gun-based immunization. PMID:29856790
Intrinsic Disorder and Posttranslational Modifications: The Darker Side of the Biological Dark Matter. PMID:29780404
CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells. PMID:29742423
Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6. PMID:29716651
Profiling plasma extracellular vesicle by pluronic block-copolymer based enrichment method unveils features associated with breast cancer aggression, metastasis and invasion. PMID:29696079
Significance of aquaporins' expression in the prognosis of gastric cancer. PMID:29678898
In silico cancer research towards 3R. PMID:29649981
The impact of tumor receptor heterogeneity on the response to anti-angiogenic cancer treatment. PMID:29623971
The Significance of Tumor Necrosis Factor Receptor Type II in CD8+ Regulatory T Cells and CD8+ Effector T Cells. PMID:29623079
Cost-effective generation of precise label-free quantitative proteomes in high-throughput by microLC and data-independent acquisition. PMID:29531254
Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour. PMID:29516617
The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis. PMID:29515971
Carbonic Anhydrases: Role in pH Control and Cancer. PMID:29495652
The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer. PMID:29495625
Tumor microenvironment heterogeneity: challenges and opportunities. PMID:29430386
Identification of proteins with the CDw75 epitope in human colorectal cancer. PMID:29391890
Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer. PMID:29382334
Somatic APC mosaicism and oligogenic inheritance in genetically unsolved colorectal adenomatous polyposis patients. PMID:29367705
Impact of FHIT loss on the translation of cancer-associated mRNAs. PMID:29282095
Protein biomarkers for subtyping breast cancer and implications for future research. PMID:29271260
Mutational Analysis of ZFY in Sporadic Parathyroid Adenomas. PMID:29264489
Large-scale identification of human cerebrovascular proteins: Inter-tissue and intracerebral vascular protein diversity. PMID:29190776
Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling. PMID:29187877
Prediction of Host-Pathogen Interactions for Helicobacter pylori by Interface Mimicry and Implications to Gastric Cancer. PMID:29106933
FLNA is implicated in pulmonary neuroendocrine tumors aggressiveness and progression. PMID:29100390
Increased IFRD1 Expression in Human Colon Cancers Predicts Reduced Patient Survival. PMID:29094309
Helicobacter pylori Affects the Antigen Presentation Activity of Macrophages Modulating the Expression of the Immune Receptor CD300E through miR-4270. PMID:29085364
Activation of Wnt-β-catenin pathway in basal-parabasal layers of normal cervical epithelium comparable during development of uterine cervical carcinoma. PMID:29079964
Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults. PMID:29064406
Role of PLZF as a tumor suppressor in prostate cancer. PMID:29050363
The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. PMID:28980860
Layilin is critical for mediating hyaluronan 35kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo. PMID:28978412
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. PMID:28977666
The human protein atlas: A spatial map of the human proteome. PMID:28940711
Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells. PMID:28933585
Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer. PMID:28881726
Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia. PMID:28870994
CTLA-4/CD80 pathway regulates T cell infiltration into pancreatic cancer. PMID:28856392
Serum fibronectin distinguishes the early stages of hepatocellular carcinoma. PMID:28842594
Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis. PMID:28831120
CRISPR-Cas9 Mediated Labelling Allows for Single Molecule Imaging and Resolution. PMID:28814796
A systems approach reveals distinct metabolic strategies among the NCI-60 cancer cell lines. PMID:28806730
Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth. PMID:28794006
Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling. PMID:28790300
Kinase Activity of Fibroblast Growth Factor Receptor 3 Regulates Activity of the Papillomavirus E2 Protein. PMID:28768864
KIBRA attains oncogenic activity by repressing RASSF1A. PMID:28664913
Affimer proteins are versatile and renewable affinity reagents. PMID:28654419
Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines. PMID:28545079
Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer. PMID:28515422
Pro-necrotic molecules impact local immunosurveillance in human breast cancer. PMID:28507808
The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome. PMID:28385950
Exploring the antigenic response to multiplexed immunizations in a chicken model of antibody production. PMID:28367512
Quantitative Shotgun Proteomics Unveils Candidate Novel Esophageal Adenocarcinoma (EAC)-specific Proteins. PMID:28336725
Effects of different kinds of essentiality on sequence evolution of human testis proteins. PMID:28272493
Let There Be Light! PMID:28248246
X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3. PMID:28176794
Protein Bioinformatics Databases and Resources. PMID:28150231
Crosstalk between the nucleolus and the DNA damage response. PMID:28112326
Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy. PMID:28097229
Glycine decarboxylase and HIF-1α expression are negative prognostic factors in primary resected early-stage non-small cell lung cancer. PMID:28062918
A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma. PMID:28052770
Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders. PMID:28008606
Epithelial ovarian carcinoma diagnosis by desorption electrospray ionization mass spectrometry imaging. PMID:27976698
Serum Autoantibody Profiling of Patients with Paraneoplastic and Non-Paraneoplastic Autoimmune Retinopathy. PMID:27930731
Distinct outcomes of CRL-Nedd8 pathway inhibition reveal cancer cell plasticity. PMID:27906189
Physiologically-based modeling to predict the clinical behavior of monoclonal antibodies directed against lymphocyte antigens. PMID:27892793
SNAP23 promotes the malignant process of ovarian cancer. PMID:27855700
p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept. PMID:27834926
Expression Data Analysis for the Identification of Potential Biomarker of Pregnancy Associated Breast Cancer. PMID:27832451
The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro. PMID:27755550
Determining protein biomarkers for DLBCL using FFPE tissues from HIV negative and HIV positive patients. PMID:27696080
Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat. PMID:27669419
Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells. PMID:27610411
Putative functions of tissue kallikrein-related peptidases in vaginal fluid. PMID:27603220
TissueWikiMobile: an Integrative Protein Expression Image Browser for Pathological Knowledge Sharing and Annotation on a Mobile Device. PMID:27532057
BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis. PMID:27528616
Pangolin genomes and the evolution of mammalian scales and immunity. PMID:27510566
The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts. PMID:27494403
Quantitative proteomic analysis for novel biomarkers of buccal squamous cell carcinoma arising in background of oral submucous fibrosis. PMID:27485544
Association of TGFβ signaling with the maintenance of a quiescent stem cell niche in human oral mucosa. PMID:27480259
Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome. PMID:27453469
Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks. PMID:27403431
Nuclear import sequence identification in hOAS3 protein. PMID:27379722
H11/HSPB8 Restricts HIV-2 Vpx to Restore the Anti-Viral Activity of SAMHD1. PMID:27379031
Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies. PMID:27377311
Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells. PMID:27344174
Cross-talk between the Tissue Factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer. PMID:27246245
Current state of the art for enhancing urine biomarker discovery. PMID:27232439
Assembly of eIF3 Mediated by Mutually Dependent Subunit Insertion. PMID:27210288
The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation. PMID:27203112
Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses. PMID:27152965
A recurrent de novo CTBP1 mutation is associated with developmental delay, hypotonia, ataxia, and tooth enamel defects. PMID:27094857
Proximity assays for sensitive quantification of proteins. PMID:27077033
HNdb: an integrated database of gene and protein information on head and neck squamous cell carcinoma. PMID:27013077
Integrin signalling regulates YAP and TAZ to control skin homeostasis. PMID:26989177
In silico and experimental analyses predict the therapeutic value of an EZH2 inhibitor GSK343 against hepatocellular carcinoma through the induction of metallothionein genes. PMID:26973856
APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis. PMID:26942872
Combined Secretomics and Transcriptomics Revealed Cancer-Derived GDF15 is Involved in Diffuse-Type Gastric Cancer Progression and Fibroblast Activation. PMID:26892343
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value. PMID:26877874
Overexpression of Kinesin Associated Protein 3 (KIFAP3) in Breast Cancer. PMID:26843789
A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. PMID:26823433
Expression of N-Acetylglucosaminyltransferase III Suppresses α2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to α2,6-Sialylation Levels. PMID:26801611
Global analysis of human duplicated genes reveals the relative importance of whole-genome duplicates originated in the early vertebrate evolution. PMID:26801093
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer. PMID:26771841
ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression. PMID:26771237
Proteomic Analysis of Epithelial to Mesenchymal Transition (EMT) Reveals Cross-talk between SNAIL and HDAC1 Proteins in Breast Cancer Cells. PMID:26764010
SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. PMID:26739564
Podocalyxin as a Prognostic Marker in Gastric Cancer. PMID:26674770
Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities. PMID:26644354
Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants. PMID:26633466
Evidence that 2-hydroxyglutarate is not readily metabolized in colorectal carcinoma cells. PMID:26629338
Hypermethylation of genes in testicular embryonal carcinomas. PMID:26625006
The potential role of PHF6 as an oncogene: a genotranscriptomic/proteomic meta-analysis. PMID:26561469
Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human. PMID:26545399
Germline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid Cancer. PMID:26522472
Use of HCA in subproteome-immunization and screening of hybridoma supernatants to define distinct antibody binding patterns. PMID:26521976
Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways. PMID:26517691
Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration. PMID:26464514
Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer. PMID:26462181
The cytotoxicity of the α1-adrenoceptor antagonist prazosin is linked to an endocytotic mechanism equivalent to transport-P. PMID:26449523
Identification of Circulating Biomarker Candidates for Hepatocellular Carcinoma (HCC): An Integrated Prioritization Approach. PMID:26414287
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. PMID:26403541
Comparative Analysis of Label-Free and 8-Plex iTRAQ Approach for Quantitative Tissue Proteomic Analysis. PMID:26331617
E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade. PMID:26246502
MI-PVT: A Tool for Visualizing the Chromosome-Centric Human Proteome. PMID:26204236
Transcriptional Perturbations in Graft Rejection. PMID:26154388
The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling. PMID:26109061
Metrabase: a cheminformatics and bioinformatics database for small molecule transporter data analysis and (Q)SAR modeling. PMID:26106450
Species-Related Differences in the Proteome of Rat and Human Pancreatic Beta Cells. PMID:26064985
Podocalyxin Is a Marker of Poor Prognosis in Pancreatic Ductal Adenocarcinoma. PMID:26053486
Multidimensional gene search with Genehopper. PMID:25990726
Protein microarrays: a new tool for the study of autoantibodies in immunodeficiency. PMID:25904912
Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer. PMID:25903835
Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis. PMID:25902861
Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer. PMID:25898255
Psoriatic arthritis under a proteomic spotlight: application of novel technologies to advance diagnosis and management. PMID:25895652
Dissecting antibodies with regards to linear and conformational epitopes. PMID:25816293
Peroxiredoxins: hidden players in the antioxidant defence of human spermatozoa. PMID:25780579
Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry. PMID:25737130
Visualization of proteomics data using R and bioconductor. PMID:25690415
Genetic variants modulating CRIPTO serum levels identified by genome-wide association study in Cilento isolates. PMID:25629528
Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel encoded by KCNJ6. PMID:25620207
Solid-phase cloning for high-throughput assembly of single and multiple DNA parts. PMID:25618848
DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance. PMID:25575823
Immunohistochemical detection of FLAG-tagged endogenous proteins in knock-in mice. PMID:25575566
Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas. PMID:25551685
The transcriptomic and proteomic landscapes of bone marrow and secondary lymphoid tissues. PMID:25541736
The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans. PMID:25491313
Automated analysis of immunohistochemistry images identifies candidate location biomarkers for cancers. PMID:25489103
Systems Medicine: from molecular features and models to the clinic in COPD. PMID:25471042
Anti-inflammatory effect of Qingwen Baidu Decoction (清瘟败毒饮) in sepsis rats. PMID:25428340
Identification of OLIG2 as the most specific glioblastoma stem cell marker starting from comparative analysis of data from similar DNA chip microarray platforms. PMID:25384509
CLIP2 as radiation biomarker in papillary thyroid carcinoma. PMID:25284583
Galectin expression profiling identifies galectin-1 and Galectin-9Δ5 as prognostic factors in stage I/II non-small cell lung cancer. PMID:25259711
Making proteomics data accessible and reusable: current state of proteomics databases and repositories. PMID:25158685
Preliminary characterization of IL32 in basal-like/triple negative compared to other types of breast cell lines and tissues. PMID:25100201
Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching. PMID:25097667
Many local pattern texture features: which is better for image-based multilabel human protein subcellular localization classification? PMID:25050396
Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: II. Role of human ZIP9 in testosterone-induced prostate and breast cancer cell apoptosis. PMID:25014355
Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer. PMID:25011585
A comparative study of two PODXL antibodies in 840 colorectal cancer patients. PMID:25004935
Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells. PMID:24913355
Structural bioinformatics of the interactome. PMID:24895853
Membrane protein profiling of human colon reveals distinct regional differences. PMID:24889196
A foundation for reliable spatial proteomics data analysis. PMID:24846987
Bottom-Up Mass Spectrometry-Based Proteomics as an Investigative Analytical Tool for Discovery and Quantification of Proteins in Biological Samples. PMID:24761338
Garbage in, garbage out: a critical evaluation of strategies used for validation of immunohistochemical biomarkers. PMID:24725481
A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies. PMID:24658685
Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. PMID:24646661
Decreased decorin expression in the tumor microenvironment. PMID:24634138
Quantitation of human metallothionein isoforms: a family of small, highly conserved, cysteine-rich proteins. PMID:24493013
Pre-B-cell leukemia homeobox interacting protein 1 is overexpressed in astrocytoma and promotes tumor cell growth and migration. PMID:24470547
Inhibiting metastatic breast cancer cell migration via the synergy of targeted, pH-triggered siRNA delivery and chemokine axis blockade. PMID:24467226
Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study. PMID:24426833
Prioritization of cancer marker candidates based on the immunohistochemistry staining images deposited in the human protein atlas. PMID:24303032
Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D₃-MARRS. PMID:24292207
BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane. PMID:24260471
Cooperative behavior of the nuclear receptor superfamily and its deregulation in prostate cancer. PMID:24104552
The human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis. PMID:24098529
Successful triple immunoenzymatic method employing primary antibodies from same species and same immunoglobulin subclass. PMID:24085271
Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells. PMID:24075906
Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. PMID:24043423
MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer. PMID:23955085
Antibodies biotinylated using a synthetic Z-domain from protein A provide stringent in situ protein detection. PMID:23920108
Mifepristone-exposured human endometrial endothelial cells in vitro. PMID:23885098
Bioinformatics for spermatogenesis: annotation of male reproduction based on proteomics. PMID:23852026
Autoantibody profiling in multiple sclerosis using arrays of human protein fragments. PMID:23732997
Variable metastatic potentials correlate with differential plectin and vimentin expression in syngeneic androgen independent prostate cancer cells. PMID:23717685
Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure. PMID:23713052
N-6-adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms and arsenic methylation in Andean women. PMID:23665909
Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy. PMID:23617393
European H16N3 gull influenza virus attaches to the human respiratory tract and eye. PMID:23593303
Knockdown of PPAR δ gene promotes the growth of colon cancer and reduces the sensitivity to bevacizumab in nude mice model. PMID:23593291
Evaluation of epigenetic modulation of cyclooxygenase-2 as a prognostic marker for hepatocellular carcinoma. PMID:23552739
Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer. PMID:23547718
Integration of clinical data with a genome-scale metabolic model of the human adipocyte. PMID:23511207
GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role. PMID:23451275
Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. PMID:23435261
Complex roles of filamin-A mediated cytoskeleton network in cancer progression. PMID:23388158
RUNX1: A microRNA hub in normal and malignant hematopoiesis. PMID:23344057
Two new cases of anti-Ca (anti-ARHGAP26/GRAF) autoantibody-associated cerebellar ataxia. PMID:23320754
Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids. PMID:23230278
Automated analysis and reannotation of subcellular locations in confocal images from the Human Protein Atlas. PMID:23226299
Regulation of ROCK activity in cancer. PMID:23204112
A gene expression atlas of the domestic pig. PMID:23153189
Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis. PMID:23131994
A tool to facilitate clinical biomarker studies--a tissue dictionary based on the Human Protein Atlas. PMID:22971420
Influencing factors on the NMP-22 urine assay: an experimental model. PMID:22928931
Postfixation detergent treatment liberates the membrane modelling protein Pex11β from peroxisomal membranes. PMID:22875152
The promyelocytic leukemia zinc finger protein: two decades of molecular oncology. PMID:22822476
Rac1 activation driven by 14-3-3ζ dimerization promotes prostate cancer cell-matrix interactions, motility and transendothelial migration. PMID:22808202
Validation of podocalyxin-like protein as a biomarker of poor prognosis in colorectal cancer. PMID:22769594
CSE1L, DIDO1 and RBM39 in colorectal adenoma to carcinoma progression. PMID:22711543
Overexpression of ribosome binding protein 1 (RRBP1) in breast cancer. PMID:22709790
Production of tissue microarrays, immunohistochemistry staining and digitalization within the human protein atlas. PMID:22688270
Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT. PMID:22615553
Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). PMID:22611424
Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes. PMID:22499770
Automatic filtering and substantiation of drug safety signals. PMID:22496632
LARP7 is a potential tumor suppressor gene in gastric cancer. PMID:22488152
Differentiating rectal carcinoma by an immunohistological analysis of carcinomas of pelvic organs based on the NCBI Literature Survey and the Human Protein Atlas database. PMID:22441574
Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. PMID:22424930
Scalable in situ hybridization on tissue arrays for validation of novel cancer and tissue-specific biomarkers. PMID:22412953
Identification of prostate-enriched proteins by in-depth proteomic analyses of expressed prostatic secretions in urine. PMID:22339264
Development of novel mouse hybridomas producing monoclonal antibodies specific to human and mouse nucleolar protein SURF-6. PMID:22316485
Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer. PMID:22228101
Functional regulation of pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1/HPIP) in erythroid differentiation. PMID:22187427
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. PMID:22159717
Antibody-based protein profiling of the human chromosome 21. PMID:22042635
Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis. PMID:22037942
RUNX1 and its understudied role in breast cancer. PMID:22024923
SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering. PMID:22015608
A Protein Epitope Signature Tag (PrEST) library allows SILAC-based absolute quantification and multiplexed determination of protein copy numbers in cell lines. PMID:21964433
High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression. PMID:21955582
Discovery of lung cancer biomarkers by profiling the plasma proteome with monoclonal antibody libraries. PMID:21947365
Air1 zinc knuckles 4 and 5 and a conserved IWRXY motif are critical for the function and integrity of the Trf4/5-Air1/2-Mtr4 polyadenylation (TRAMP) RNA quality control complex. PMID:21878619
Overexpression of podocalyxin-like protein is an independent factor of poor prognosis in colorectal cancer. PMID:21829192
Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: an analysis of 215 cases from the Malmö Diet and Cancer Study. PMID:21777469
Toponostics of invasive ductal breast carcinoma: combination of spatial protein expression imaging and quantitative proteome signature analysis. PMID:21738817
Deeply dissecting stemness: making sense to non-coding RNAs in stem cells. PMID:21706141
Translational database selection and multiplexed sequence capture for up front filtering of reliable breast cancer biomarker candidates. PMID:21698250
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases. PMID:21681677
Antibodies on demand: a fast method for the production of human scFvs with minimal amounts of antigen. PMID:21635725
Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases. PMID:21626272
A Graphical Model to Determine the Subcellular Protein Location in Artificial Tissues. PMID:21625289
Identification and characterization of human leukocyte antigen class I ligands in renal cell carcinoma cells. PMID:21595034
Tumor-targeted RNA-interference: functional non-viral nanovectors. PMID:21572539
A roadmap to generate renewable protein binders to the human proteome. PMID:21572409
Stromal expression of β-arrestin-1 predicts clinical outcome and tamoxifen response in breast cancer. PMID:21497294
The Structural Biology Knowledgebase: a portal to protein structures, sequences, functions, and methods. PMID:21472436
Growth differentiation factor 15: a prognostic marker for recurrence in colorectal cancer. PMID:21468045
A cell spot microarray method for production of high density siRNA transfection microarrays. PMID:21443765
Histochemical localization of caldesmon in the CNS and ganglia of the mouse. PMID:21411712
Functional characterization of peroxisome proliferator-activated receptor-β/δ expression in colon cancer. PMID:21400612
Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. PMID:21346778
Multiplexed protein analysis using encoded antibody-conjugated microbeads. PMID:21247950
Global expression of cell surface proteins in embryonic stem cells. PMID:21209962
An informatics-assisted label-free approach for personalized tissue membrane proteomics: case study on colorectal cancer. PMID:21209152
Genomics and proteomics in stem cell research: the road ahead. PMID:21190000
Defining the transcriptome and proteome in three functionally different human cell lines. PMID:21179022
Differential expression of anterior gradient gene AGR2 in prostate cancer. PMID:21144054
Towards a knowledge-based Human Protein Atlas. PMID:21139605
Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer. PMID:20727170
Antibody-based proteomics: fast-tracking molecular diagnostics in oncology. PMID:20720569
Binding of pro-prion to filamin A: by design or an unfortunate blunder. PMID:20697352
Toward next generation plasma profiling via heat-induced epitope retrieval and array-based assays. PMID:20682762
Gene expression analysis after receptor tyrosine kinase activation reveals new potential melanoma proteins. PMID:20663135
Automated Analysis of Human Protein Atlas Immunofluorescence Images. PMID:20628548
Automated Proteome-Wide Determination of Subcellular Location Using High Throughput Microscopy. PMID:20622996
Proteomics data repositories: providing a safe haven for your data and acting as a springboard for further research. PMID:20615486
Methyl CpG binding protein 2 (MeCP2) enhances photodimer formation at methyl-CpG sites but suppresses dimer deamination. PMID:20601406
Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon. PMID:20529129
Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787. PMID:20516370
Bioinformatic identification and characterization of human endothelial cell-restricted genes. PMID:20509943
Antibody array-based technologies for cancer protein profiling and functional proteomic analyses using serum and tissue specimens. PMID:20358423
O Labeling for a Quantitative Proteomic Analysis of Glycoproteins in Hepatocellular Carcinoma. PMID:20357908
In-depth proteomic analyses of direct expressed prostatic secretions. PMID:20334419
Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display. PMID:20164216
Protein subcellular localization profiling of breast cancer cells by dissociable antibody microarray staining. PMID:20127686
A generative model of microtubule distributions, and indirect estimation of its parameters from fluorescence microscopy images. PMID:20104579
Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. PMID:20068171
Secretagogin is a Ca2+-binding protein specifying subpopulations of telencephalic neurons. PMID:20018755
Development of an automatic quantification method for cancer tissue microarray study. PMID:19964806
The impact of tissue fixatives on morphology and antibody-based protein profiling in tissues and cells. PMID:19901271
Perspectives of targeted mass spectrometry for protein biomarker verification. PMID:19818677
Urinary proteomic profiling for diagnostic bladder cancer biomarkers. PMID:19811072
Cancer proteomics--an evolving battlefield. Conference on Cancer Proteomics 2009: Mechanistic Insights, Technological Advances & Molecular Medicine. PMID:19798100
Efficient framework for automated classification of subcellular patterns in budding yeast. PMID:19753630
A community standard format for the representation of protein affinity reagents. PMID:19674966
Proteomics Discovery of Disease Biomarkers. PMID:19578516
Glomerular protein levels of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 are lower in diabetic subjects. PMID:19506087
Toward digital staining using imaging mass spectrometry and random forests. PMID:19469555
Posttranscriptional down-regulation of small ribosomal subunit proteins correlates with reduction of 18S rRNA in RPS19 deficiency. PMID:19454283
Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. PMID:19351664
14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival. PMID:19318578
A multi-Fc-species system for recombinant antibody production. PMID:19245715
Creation, validation, and quantitative analysis of protein expression in vascular tissue microarrays. PMID:19211265
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. PMID:19133145
SysZNF: the C2H2 zinc finger gene database. PMID:18974185
Human Proteinpedia: a unified discovery resource for proteomics research. PMID:18948298
Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer. PMID:18947395
Combining results from lectin affinity chromatography and glycocapture approaches substantially improves the coverage of the glycoproteome. PMID:18923192
The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury. PMID:18834514
Proteomic changes during intestinal cell maturation in vivo. PMID:18824147
[Virtual microscopy in systems pathology]. PMID:18820917
Identification of a new WASP and FKBP-like (WAFL) protein in inflammatory bowel disease: a potential marker gene for ulcerative colitis. PMID:18654788
Parallel gene expression profiling of mantle cell lymphoma - how do we transform 'omics data into clinical practice. PMID:18645603
2DB: a Proteomics database for storage, analysis, presentation, and retrieval of information from mass spectrometric experiments. PMID:18605993
Human Proteinpedia as a resource for clinical proteomics. PMID:18573810
Conserved footprints of APOBEC3G on Hypermutated human immunodeficiency virus type 1 and human endogenous retrovirus HERV-K(HML2) sequences. PMID:18562517
The epitope space of the human proteome. PMID:18359855
Prognostic ability of a panel of immunohistochemistry markers - retailoring of an 'old solution'. PMID:18331621
In silico detection of sequence variations modifying transcriptional regulation. PMID:18208319
Linking the ovarian cancer transcriptome and immunome. PMID:18173842
Blocking endogenous peroxidases: a cautionary note for immunohistochemistry. PMID:18053079
Application of phage display to high throughput antibody generation and characterization. PMID:18047641
The glomerular transcriptome and a predicted protein-protein interaction network. PMID:18032794
The Stanford Tissue Microarray Database. PMID:17989087
Evaluation of staphylococcal cell surface display and flow cytometry for postselectional characterization of affinity proteins in combinatorial protein engineering applications. PMID:17873070
Microarray analysis of gliomas reveals chromosomal position-associated gene expression patterns and identifies potential immunotherapy targets. PMID:17634744
Maturation of the mammalian secretome. PMID:17472737
From bytes to bedside: data integration and computational biology for translational cancer research. PMID:17319736
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics. PMID:16957166
Tissue microarrays as a platform for proteomic investigation. PMID:16953460
The subcellular localization of the mammalian proteome comes a fraction closer. PMID:16938898
Advances and challenges in liquid chromatography-mass spectrometry-based proteomics profiling for clinical applications. PMID:16887931
High throughput protein expression screening in the nervous system--needs and limitations. PMID:16793899
AbMiner: a bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies. PMID:16600027
Recent advances of protein microarrays. PMID:16376134 -
The Human Protein Atlas--a tool for pathology
PubMed citations: 350.
350 articles citing: The Human Protein Atlas--a tool for pathology
Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas. PMID:35906698
The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma. PMID:35875075
Contribution of septins to human platelet structure and function. PMID:35832887
MFAP4-Mediated Effects in Elastic Fiber Homeostasis, Integrin Signaling and Cancer, and Its Role in Teleost Fish. PMID:35805199
Syringin exerts anti-breast cancer effects through PI3K-AKT and EGFR-RAS-RAF pathways. PMID:35794555
PIK3R3, a regulatory subunit of PI3K, modulates ovarian cancer stem cells and ovarian cancer development and progression by integrative analysis. PMID:35761259
ASPM and TROAP gene expression as potential malignant tumor markers. PMID:35722431
Comprehensive Analysis of the Expression and Prognosis for MCM4 in Uterine Corpus Endometrial Carcinoma. PMID:35719366
Expression of apoptosis-related proteins in the pathogenesis of endometrial clear cell carcinoma. PMID:35698635
Low CRIM1 Levels Predict Poor Prognosis in Breast Cancer Patients. PMID:35600360
Prognostic Biomarker KIF18A and Its Correlations With Immune Infiltrates and Mitosis in Glioma. PMID:35591854
The E3 Ubiquitin Ligase Fbxo4 Functions as a Tumor Suppressor: Its Biological Importance and Therapeutic Perspectives. PMID:35565262
Identification of immune-related biomarkers associated with tumorigenesis and prognosis in skin cutaneous melanoma. PMID:35530289
Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancer. PMID:35436325
NUSAP1 Could be a Potential Target for Preventing NAFLD Progression to Liver Cancer. PMID:35431924
Prognostic Relevance of ZNF844 and Chr 19p13.2 KRAB-Zinc Finger Proteins in Clear Cell Renal Carcinoma. PMID:35430565
PTPN14 Mutations and Cervical Cancer. PMID:35403138
Characterization of Pyroptosis-Related Subtypes via RNA-Seq and ScRNA-Seq to Predict Chemo-Immunotherapy Response in Triple-Negative Breast Cancer. PMID:35386285
A Pan-Cancer Bioinformatic Analysis of RAD51 Regarding the Values for Diagnosis, Prognosis, and Therapeutic Prediction. PMID:35359409
PUMILIO proteins promote colorectal cancer growth via suppressing p21. PMID:35338151
Evaluation of the Prognostic Relevance of Differential Claudin Gene Expression Highlights Claudin-4 as Being Suppressed by TGFβ1 Inhibitor in Colorectal Cancer. PMID:35281827
HIDTI: integration of heterogeneous information to predict drug-target interactions. PMID:35260608
Identification of key genes associated with polycystic ovary syndrome (PCOS) and ovarian cancer using an integrated bioinformatics analysis. PMID:35227296
Guanylate-Binding Protein 1 as a Potential Predictor of Immunotherapy: A Pan-Cancer Analysis. PMID:35222540
High Expression of PLAGL2 is Associated With Poor Prognosis in High-Grade Glioma. PMID:35222518
Molecular Signature of Tumor-Associated High Endothelial Venules That Can Predict Breast Cancer Survival. PMID:35201289
Postnatal expression of IGF2 is the norm in amniote vertebrates. PMID:35193406
Quantitative Estimation of Protein in Sprouts of Vigna radiate (Mung Beans), Lens culinaris (Lentils), and Cicer arietinum (Chickpeas) by Kjeldahl and Lowry Methods. PMID:35164080
Up-Regulation of Cyclooxygenase-2 (COX-2) Expression by Temozolomide (TMZ) in Human Glioblastoma (GBM) Cell Lines. PMID:35163465
Characterization of Pipefish Immune Cell Populations Through Single-Cell Transcriptomics. PMID:35154138
CPNE1 is a potential prognostic biomarker, associated with immune infiltrates and promotes progression of hepatocellular carcinoma. PMID:35139863
EMG1 interacts with NOP14 to regulate the growth, migration, and invasion of melanoma cells via the Wnt/β-catenin pathway. PMID:35117729
A comprehensive bioinformatics analysis to identify a candidate prognostic biomarker for ovarian cancer. PMID:35116478
Comprehensive Analysis of Cell Cycle-Related Genes in Patients With Prostate Cancer. PMID:35087757
HIF-1α Is a Rational Target for Future Ovarian Cancer Therapies. PMID:35004308
piRNAQuest V.2: an updated resource for searching through the piRNAome of multiple species. PMID:34965192
Mapping the Melanoma Plasma Proteome (MPP) Using Single-Shot Proteomics Interfaced with the WiMT Database. PMID:34944842
A System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach. PMID:34944525
Prognostic biomarker SMARCC1 and its association with immune infiltrates in hepatocellular carcinoma. PMID:34937564
Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics. PMID:34900668
Gene Network Analysis of Hepatocellular Carcinoma Identifies Modules Associated with Disease Progression, Survival, and Chemo Drug Resistance. PMID:34898998
Epstein-Barr Virus+ B Cells in Breast Cancer Immune Response: A Case Report. PMID:34868006
B0AT1 Amino Acid Transporter Complexed With SARS-CoV-2 Receptor ACE2 Forms a Heterodimer Functional Unit: In Situ Conformation Using Radiation Inactivation Analysis. PMID:34847569
Prognostic characterization of immune molecular subtypes in non-small cell lung cancer to immunotherapy. PMID:34844602
The Identification of RNA Modification Gene PUS7 as a Potential Biomarker of Ovarian Cancer. PMID:34827123
In silico Methods for Identification of Potential Therapeutic Targets. PMID:34826045
Retinaldehyde Dehydrogenase Inhibition-Related Adverse Outcome Pathway: Potential Risk of Retinoic Acid Synthesis Inhibition during Embryogenesis. PMID:34822523
Predicting Human Protein Subcellular Locations by Using a Combination of Network and Function Features. PMID:34804131
The possible role of SRMS in colorectal cancer by bioinformatics analysis. PMID:34781983
Prognostic biomarkers for predicting papillary thyroid carcinoma patients at high risk using nine genes of apoptotic pathway. PMID:34767591
Non-Invasive Characterization of the Pancreas During Bariatric Surgery via Circulating Pancreatic Specific Cell-free Messenger RNA. PMID:34707641
Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors. PMID:34706560
In silico assessment of a novel single-molecule protein fingerprinting method employing fragmentation and nanopore detection. PMID:34703997
Identification and validation of an autophagy-related signature for predicting survival in lower-grade glioma. PMID:34696669
Integrated bioinformatics analyses of key genes involved in hepatocellular carcinoma immunosuppression. PMID:34691257
The Role of Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 in the Pathogenesis of Human Cancer. PMID:34681622
Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma. PMID:34649520
Expression and clinical significance of TIMELESS in glioma. PMID:34646412
Long non‑coding RNA HHIP‑AS1 inhibits lung cancer epithelial‑mesenchymal transition and stemness by regulating PCDHGA9. PMID:34643245
Current Development and Application of Anaerobic Glycolytic Enzymes in Urothelial Cancer. PMID:34638949
A New Approach for Prostate Cancer Diagnosis by miRNA Profiling of Prostate-Derived Plasma Small Extracellular Vesicles. PMID:34572021
miRNATissueAtlas2: an update to the human miRNA tissue atlas. PMID:34570238
Novel Insight Into Glycosaminoglycan Biosynthesis Based on Gene Expression Profiles. PMID:34552927
Suppression of ANT2 by miR-137 Inhibits Prostate Tumorigenesis. PMID:34539732
CXCL9 Is a Potential Biomarker of Immune Infiltration Associated With Favorable Prognosis in ER-Negative Breast Cancer. PMID:34527583
Tune the channel: TRPM8 targeting in prostate cancer. PMID:34514058
Association of Circulating, Inflammatory-Response Exosomal mRNAs With Acute Myocardial Infarction. PMID:34490374
Integrative Analysis of Minichromosome Maintenance Proteins and Their Prognostic Significance in Melanoma. PMID:34490114
Caveolin-1, a Key Mediator Across Multiple Pathways in Glioblastoma and an Independent Negative Biomarker of Patient Survival. PMID:34490102
Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation. PMID:34482382
Elevated tumor expression of Astroprincin (FAM171A1) is an independent marker of poor prognosis in colon cancer. PMID:34481452
Intersection of Redox Chemistry and Ubiquitylation: Post-Translational Modifications Required for Maintaining Cellular Homeostasis and Neuroprotection. PMID:34440890
Biomolecule and Bioentity Interaction Databases in Systems Biology: A Comprehensive Review. PMID:34439912
The Identification of Zinc-Finger Protein 433 as a Possible Prognostic Biomarker for Clear-Cell Renal Cell Carcinoma. PMID:34439859
Probing Synergistic Targets by Natural Compounds for Hepatocellular Carcinoma. PMID:34395446
Expression and prognostic significance of CBX2 in colorectal cancer: database mining for CBX family members in malignancies and vitro analyses. PMID:34321009
A miR-212-3p/SLC6A1 Regulatory Sub-Network for the Prognosis of Hepatocellular Carcinoma. PMID:34234551
High IER5 Gene Expression Is Associated With Poor Prognosis in Glioma Patients. PMID:34222249
TGM4: an immunogenic prostate-restricted antigen. PMID:34193566
Identification of significant genes and therapeutic agents for breast cancer by integrated genomics. PMID:34151730
Multiple Reaction Monitoring-Based Targeted Assays for the Validation of Protein Biomarkers in Brain Tumors. PMID:34055594
Identification of potential diagnostic and prognostic biomarkers for LUAD based on TCGA and GEO databases. PMID:34017995
Impact of histological response after neoadjuvant therapy on podocalyxin as a prognostic marker in pancreatic cancer. PMID:33972616
Ferret Interferon (IFN)-Inducible Transmembrane Proteins Are Upregulated by both IFN-α and Influenza Virus Infection. PMID:33952646
The effect of cell isolation methods on the human transcriptome profiling and microbial transcripts of peripheral blood. PMID:33929647
The Leloir Cycle in Glioblastoma: Galactose Scavenging and Metabolic Remodeling. PMID:33920278
Evidence for a Negative Correlation between Human Reactive Enamine-Imine Intermediate Deaminase A (RIDA) Activity and Cell Proliferation Rate: Role of Lysine Succinylation of RIDA. PMID:33916919
Prognostic Signature for Lung Adenocarcinoma Patients Based on Cell-Cycle-Related Genes. PMID:33869220
Search, access, and explore life science nanopublications on the Web. PMID:33816986
Relevance of 2'-O-Methylation and Pseudouridylation for the Malignant Melanoma. PMID:33803145
Proteomics Profiling of Neuron-Derived Small Extracellular Vesicles from Human Plasma: Enabling Single-Subject Analysis. PMID:33799461
Pan-cancer analysis identifies ITIH1 as a novel prognostic indicator for hepatocellular carcinoma. PMID:33744857
Galectin-4 as a Novel Biomarker of Neonatal Intestinal Injury. PMID:33738671
Kidney involvement in coronavirus-associated diseases (Review). PMID:33732334
High expression of aldolase A is associated with tumor progression and poor prognosis in hepatocellular carcinoma. PMID:33708434
Identification of theranostic factors for patients developing metastasis after surgery for early-stage lung adenocarcinoma. PMID:33664854
Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients. PMID:33633121
Effect of Glucose Variability on Pancreatic Cancer Through Regulation of COL6A1. PMID:33603474
V-ATPase Inhibition Decreases Mutant Androgen Receptor Activity in Castrate-resistant Prostate Cancer. PMID:33563753
Inhibition of relaxin autocrine signaling confers therapeutic vulnerability in ovarian cancer. PMID:33561012
Identification of Hub Genes Associated With Immune Infiltration and Predict Prognosis in Hepatocellular Carcinoma via Bioinformatics Approaches. PMID:33505422
Spermatogonial Gene Networks Selectively Couple to Glutathione and Pentose Phosphate Metabolism but Not Cysteine Biosynthesis. PMID:33458605
Primary Sjogren syndrome increases the risk of bisphosphonate-related osteonecrosis of the jaw. PMID:33452297
Transcript levels of keratin 1/5/6/14/15/16/17 as potential prognostic indicators in melanoma patients. PMID:33441834
Cytosolic Ca2+ transients during pulsed focused ultrasound generate reactive oxygen species and cause DNA damage in tumor cells. PMID:33391495
Identification of tumor-associated macrophage subsets that are associated with breast cancer prognosis. PMID:33377644
Immunohistochemical Analysis of PGC-1α and ERRα Expression Reveals Their Clinical Significance in Human Ovarian Cancer. PMID:33376354
Novel RB1 and MET Gene Mutations in a Case with Bilateral Retinoblastoma Followed by Multiple Metastatic Osteosarcoma. PMID:33375764
Glioblastoma CUSA Fluid Protein Profiling: A Comparative Investigation of the Core and Peripheral Tumor Zones. PMID:33374813
Potential benefits of dietary seaweeds as protection against COVID-19. PMID:33341894
CCTs as new biomarkers for the prognosis of head and neck squamous cancer. PMID:33313411
GJA1 Expression and Its Prognostic Value in Cervical Cancer. PMID:33299882
Overexpression of FAM234B Predicts Poor Prognosis in Patients with Luminal Breast Cancer. PMID:33299353
Exploration in the Mechanism of Kaempferol for the Treatment of Gastric Cancer Based on Network Pharmacology. PMID:33145355
Lymphocyte antigen 6 superfamily member D is a marker of urothelial and squamous differentiation: implications for risk stratification of bladder cancer. PMID:33042546
Screening of autophagy genes as prognostic indicators for glioma patients. PMID:33042422
Prognostic Score-based Clinical Factors and Metabolism-related Biomarkers for Predicting the Progression of Hepatocellular Carcinoma. PMID:33013158
Single cell sequencing unraveling genetic basis of severe COVID19 in obesity. PMID:32995660
Prognostic value of aberrantly expressed methylation genes in human hepatocellular carcinoma. PMID:32955083
Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma. PMID:32951278
Prospective evaluation of the lymph node proteome in dogs with multicentric lymphoma supplemented with sulforaphane. PMID:32926463
Identification and validation of a prognostic index based on a metabolic-genomic landscape analysis of ovarian cancer. PMID:32880385
[Pharmacology and Clinical Evaluation of Ensartinib Hydrochloride Capsule]. PMID:32838492
Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt. PMID:32814826
Gene expression of the IGF hormones and IGF binding proteins across time and tissues in a model reptile. PMID:32776803
Screening potential microRNAs associated with pancreatic cancer: Data mining based on RNA sequencing and microarrays. PMID:32765765
Prognostic implication and functional annotations of APOBEC3G expression in patients with Melanoma. PMID:32742470
The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis. PMID:32717840
Identification of potential markers for type 2 diabetes mellitus via bioinformatics analysis. PMID:32705173
Autophagy and Tumor Database: ATdb, a novel database connecting autophagy and tumor. PMID:32681639
Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers. PMID:32679804
Integrated analysis of optical mapping and whole-genome sequencing reveals intratumoral genetic heterogeneity in metastatic lung squamous cell carcinoma. PMID:32676329
Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells. PMID:32664515
Epigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Non-Small Cell Lung Cancer. PMID:32646968
High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer. PMID:32627041
Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection. PMID:32602627
Elevated expression of minichromosome maintenance 3 indicates poor outcomes and promotes G1/S cell cycle progression, proliferation, migration and invasion in colorectal cancer. PMID:32597491
Silver(I) metallodrugs of thiosemicarbazones and naproxen: biocompatibility, in vitro anti-proliferative activity and in silico interaction studies with EGFR, VEGFR2 and LOX receptors. PMID:32440336
RNA-Binding Proteins in Acute Leukemias. PMID:32408494
Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. PMID:32382484
The New Biomarker for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) Based on Public Database Mining. PMID:32351997
Non-invasive urinary sediment double-immunostaining predicts BK polyomavirus associated-nephropathy in kidney transplant recipients. PMID:32309382
Oncogene inference optimization using constraint-based modelling incorporated with protein expression in normal and tumour tissues. PMID:32269785
Silencing of keratin 17 by lentivirus-mediated short hairpin RNA inhibits the proliferation of PANC-1 human pancreatic cancer cells. PMID:32269627
Keratin 36, a specific marker of tongue filiform papillae, is downregulated in squamous cell carcinoma of the mobile tongue. PMID:32257198
Characterization of the relationship between FLI1 and immune infiltrate level in tumour immune microenvironment for breast cancer. PMID:32249526
Pseudogene-gene functional networks are prognostic of patient survival in breast cancer. PMID:32241256
Decreased Expression of NUSAP1 Predicts Poor Overall Survival in Cervical Cancer. PMID:32226503
Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. PMID:32193359
Upregulation of desmoglein 2 and its clinical value in lung adenocarcinoma: a comprehensive analysis by multiple bioinformatics methods. PMID:32095325
Pan-tissue transcriptome analysis of long noncoding RNAs in the American beaver Castor canadensis. PMID:32050897
MYOCD and SMAD3/SMAD4 form a positive feedback loop and drive TGF-β-induced epithelial-mesenchymal transition in non-small cell lung cancer. PMID:32029901
Autophagy-related gene P4HB: a novel diagnosis and prognosis marker for kidney renal clear cell carcinoma. PMID:32003756
Utility of primary cells to examine NPC1 receptor expression in Mops condylurus, a potential Ebola virus reservoir. PMID:31961874
Peptidomic Analysis of Urine from Youths with Early Type 1 Diabetes Reveals Novel Bioactivity of Uromodulin Peptides In Vitro. PMID:31879271
A genome-scale CRISPR/Cas9 knockout screening reveals SH3D21 as a sensitizer for gemcitabine. PMID:31844142
Expression and potential prognostic value of histone family gene signature in breast cancer. PMID:31772649
Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis. PMID:31748414
Tissue-Wide Gene Expression Analysis of Sodium/Phosphate Co-Transporters in Pigs. PMID:31717287
Investigating Novel Genes Potentially Involved in Endometrial Adenocarcinoma using Next-Generation Sequencing and Bioinformatic Approaches. PMID:31692912
Identification of RAD54 homolog B as a promising therapeutic target for breast cancer. PMID:31612045
Zeta-crystallin: a moonlighting player in cancer. PMID:31563996
Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma. PMID:31545501
miR-125a-5p inhibits tumorigenesis in hepatocellular carcinoma. PMID:31527306
Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development. PMID:31505876
HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. PMID:31500569
Molecular modelling and docking of Mus musculus HMGB1 inflammatory protein with CGA. PMID:31485132
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information. PMID:31475990
Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer. PMID:31467540
Post-transcriptional Regulation of Colorectal Cancer: A Focus on RNA-Binding Proteins. PMID:31440515
Compression-induced expression of glycolysis genes in CAFs correlates with EMT and angiogenesis gene expression in breast cancer. PMID:31428701
BolA family member 2 enhances cell proliferation and predicts a poor prognosis in hepatocellular carcinoma with tumor hemorrhage. PMID:31413749
DNA hypermethylation of aurora kinase A in hepatitis C virus‑positive hepatocellular carcinoma. PMID:31322223
Paucimannosidic glycoepitopes inhibit tumorigenic processes in glioblastoma multiforme. PMID:31320997
Identification of potential diagnostic and therapeutic target genes for lung squamous cell carcinoma. PMID:31289486
COL6A1 promotes metastasis and predicts poor prognosis in patients with pancreatic cancer. PMID:31268154
Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients. PMID:31167651
17-Hydroxy Wortmannin Restores TRAIL's Response by Ameliorating Increased Beclin 1 Level and Autophagy Function in TRAIL-Resistant Colon Cancer Cells. PMID:31092562
Targeting Tumor Vascular CD99 Inhibits Tumor Growth. PMID:31001265
Down syndrome mouse models have an abnormal enteric nervous system. PMID:30998504
Overexpression of CKS2 is associated with a poor prognosis and promotes cell proliferation and invasion in breast cancer. PMID:30957190
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme. PMID:30867843
Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics. PMID:30784661
If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease. PMID:30775245
Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR. PMID:30719032
A Retrospective Analysis of the Cartilage Kunitz Protease Inhibitory Proteins Identifies These as Members of the Inter-α-Trypsin Inhibitor Superfamily with Potential Roles in the Protection of the Articulatory Surface. PMID:30678366
Differential expression of RNA exosome subunits in the amphibian Lithobates catesbeianus during reproductive and non-reproductive periods. PMID:30665462
Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes. PMID:30658994
Identification of candidate target genes for endometrial cancer, such as ANO1, using weighted gene co-expression network analysis. PMID:30651795
Whole-exome sequencing reveals SALL4 variants in premature ovarian insufficiency: an update on genotype-phenotype correlations. PMID:30603774
Ovarian Cancer Prognostic Prediction Model Using RNA Sequencing Data. PMID:30602093
Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bio-orthogonally Conjugated Drug. PMID:30540482
C/VDdb: A multi-omics expression profiling database for a knowledge-driven approach in cardiovascular disease (CVD). PMID:30419069
Chromosome 17 Missing Proteins: Recent Progress and Future Directions as Part of the neXt-MP50 Challenge. PMID:30280577
SERPINB7 Expression Predicts Poor Pancreatic Cancer Survival Upon Gemcitabine Treatment. PMID:30245304
An autoantibody identifies arrhythmogenic right ventricular cardiomyopathy and participates in its pathogenesis. PMID:30239670
FOXC1 induces cancer stem cell-like properties through upregulation of beta-catenin in NSCLC. PMID:30189871
Fenton reactions drive nucleotide and ATP syntheses in cancer. PMID:30016460
RNA Sequencing and Pathway Analysis Identify Important Pathways Involved in Hypertrichosis and Intellectual Disability in Patients with Wiedemann-Steiner Syndrome. PMID:30014449
Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer. PMID:30005601
Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population. PMID:29945935
Towards personalized tumor markers. PMID:29872704
Response to the comment on "Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma" by Bielamowicz et al. PMID:29788442
Ensartinib (X-396) in ALK-Positive Non-Small Cell Lung Cancer: Results from a First-in-Human Phase I/II, Multicenter Study. PMID:29563138
Genome-wide analysis of endogenously expressed ZEB2 binding sites reveals inverse correlations between ZEB2 and GalNAc-transferase GALNT3 in human tumors. PMID:29516288
Atypical chemokine receptor CCRL2 is overexpressed in prostate cancer cells. PMID:29497024
Two protein-coding genes act as a novel clinical signature to predict prognosis in patients with ovarian serous cystadenocarcinoma. PMID:29456732
Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer. PMID:29382334
Doxycycline inhibits breast cancer EMT and metastasis through PAR-1/NF-κB/miR-17/E-cadherin pathway. PMID:29285218
Protein biomarkers for subtyping breast cancer and implications for future research. PMID:29271260
MiR-3613-3p affects cell proliferation and cell cycle in hepatocellular carcinoma. PMID:29190974
Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling. PMID:29187877
IGFBP-4 expression is adversely associated with lung cancer prognosis. PMID:29163706
Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy. PMID:29100430
MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease. PMID:28987423
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. PMID:28977666
Modeling of RAS complexes supports roles in cancer for less studied partners. PMID:28815022
Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis. PMID:28742074
Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology. PMID:28697345
Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts. PMID:28510153
Pro-necrotic molecules impact local immunosurveillance in human breast cancer. PMID:28507808
Protein Markers Associated with an ALDH Sub-Population in Colorectal Cancer. PMID:28503055
Human Cytomegalovirus-Induced Degradation of CYTIP Modulates Dendritic Cell Adhesion and Migration. PMID:28484459
Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer. PMID:28341962
Extracellular Proton Concentrations Impacts LN229 Glioblastoma Tumor Cell Fate via Differential Modulation of Surface Lipids. PMID:28299282
Insights into Diabetic Kidney Disease Using Urinary Proteomics and Bioinformatics. PMID:28159781
Overexpression of cytochrome P450 2A6 in adrenocortical carcinoma. PMID:28073588
The Human Skeletal Muscle Proteome Project: a reappraisal of the current literature. PMID:27897395
Physiologically-based modeling to predict the clinical behavior of monoclonal antibodies directed against lymphocyte antigens. PMID:27892793
Suppression of cytochrome P450 4B1: An early event in adrenocortical tumorigenesis. PMID:27865598
SNAP23 promotes the malignant process of ovarian cancer. PMID:27855700
Expression Data Analysis for the Identification of Potential Biomarker of Pregnancy Associated Breast Cancer. PMID:27832451
High Caveolin-1 Expression in Tumor Stroma Is Associated with a Favourable Outcome in Prostate Cancer Patients Managed by Watchful Waiting. PMID:27764093
Determining protein biomarkers for DLBCL using FFPE tissues from HIV negative and HIV positive patients. PMID:27696080
Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry. PMID:27670688
Pangolin genomes and the evolution of mammalian scales and immunity. PMID:27510566
Identification of susceptibility gene associated with female primary Sjögren's syndrome in Han Chinese by genome-wide association study. PMID:27503288
Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks. PMID:27403431
Nuclear import sequence identification in hOAS3 protein. PMID:27379722
H11/HSPB8 Restricts HIV-2 Vpx to Restore the Anti-Viral Activity of SAMHD1. PMID:27379031
Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies. PMID:27377311
Expression of CCL21 in Ewing sarcoma shows an inverse correlation with metastases and is a candidate target for immunotherapy. PMID:27369431
Two genetic variants in telomerase-associated protein 1 are associated with stomach cancer risk. PMID:27305982
Current state of the art for enhancing urine biomarker discovery. PMID:27232439
Pan-cancer analyses of the nuclear receptor superfamily. PMID:27200367
Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation. PMID:27180681
De novo truncating variants in the AHDC1 gene encoding the AT-hook DNA-binding motif-containing protein 1 are associated with intellectual disability and developmental delay. PMID:27148574
Commercially available antibodies can be applied in quantitative multiplexed peptide immunoaffinity enrichment targeted mass spectrometry assays. PMID:27094115
Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome. PMID:27030248
EPIG-Seq: extracting patterns and identifying co-expressed genes from RNA-Seq data. PMID:27004791
Integrin signalling regulates YAP and TAZ to control skin homeostasis. PMID:26989177
Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival. PMID:26979459
In silico and experimental analyses predict the therapeutic value of an EZH2 inhibitor GSK343 against hepatocellular carcinoma through the induction of metallothionein genes. PMID:26973856
Distribution of miRNA expression across human tissues. PMID:26921406
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value. PMID:26877874
Ankyrin Repeat Domain 1 is Up-regulated During Hepatitis C Virus Infection and Regulates Hepatitis C Virus Entry. PMID:26860204
Hyperpolarization-activated cation and T-type calcium ion channel expression in porcine and human renal pacemaker tissues. PMID:26805464
Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications. PMID:26791754
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer. PMID:26771841
ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression. PMID:26771237
Pan-cancer analysis for studying cancer stage using protein expression data. PMID:26738195
Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins. PMID:26724866
New Colors for Histology: Optimized Bivariate Color Maps Increase Perceptual Contrast in Histological Images. PMID:26717571
The Urinary Bladder Transcriptome and Proteome Defined by Transcriptomics and Antibody-Based Profiling. PMID:26694548
Podocalyxin as a Prognostic Marker in Gastric Cancer. PMID:26674770
Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants. PMID:26633466
Experimental detection of short regulatory motifs in eukaryotic proteins: tips for good practice as well as for bad. PMID:26581338
FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas. PMID:26494976
Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality. PMID:26451775
Siaα2-3Galβ1- Receptor Genetic Variants Are Associated with Influenza A(H1N1)pdm09 Severity. PMID:26436774
Identification of Circulating Biomarker Candidates for Hepatocellular Carcinoma (HCC): An Integrated Prioritization Approach. PMID:26414287
A cultured approach to canine urothelial carcinoma: molecular characterization of five cell lines. PMID:26401343
Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer. PMID:26237329
The extracellular matrix: Tools and insights for the "omics" era. PMID:26163349
Extensive rewiring of epithelial-stromal co-expression networks in breast cancer. PMID:26087699
Defining the Human Brain Proteome Using Transcriptomics and Antibody-Based Profiling with a Focus on the Cerebral Cortex. PMID:26076492
Podocalyxin Is a Marker of Poor Prognosis in Pancreatic Ductal Adenocarcinoma. PMID:26053486
The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice. PMID:26021489
Interactive Effects of N6AMT1 and As3MT in Arsenic Biomethylation. PMID:25997655
Podocyte p53 Limits the Severity of Experimental Alport Syndrome. PMID:25967122
A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues. PMID:25911998
Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression. PMID:25693195
The kidney transcriptome and proteome defined by transcriptomics and antibody-based profiling. PMID:25551756
Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas. PMID:25551685
The transcriptomic and proteomic landscapes of bone marrow and secondary lymphoid tissues. PMID:25541736
Old, new and emerging functions of caspases. PMID:25526085
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion. PMID:25400580
Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis. PMID:25397670
Identification of OLIG2 as the most specific glioblastoma stem cell marker starting from comparative analysis of data from similar DNA chip microarray platforms. PMID:25384509
Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue. PMID:25329061
Many local pattern texture features: which is better for image-based multilabel human protein subcellular localization classification? PMID:25050396
Deregulated expression of annexin-A2 and galectin-3 is associated with metastasis in gastric cancer patients. PMID:25034653
A comparative study of two PODXL antibodies in 840 colorectal cancer patients. PMID:25004935
Dysplastic hepatocytes develop nuclear inclusions in a mouse model of viral hepatitis. PMID:24932583
The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling. PMID:24789573
Whole-genome analysis of temporal gene expression during early transdifferentiation of human lung alveolar epithelial type 2 cells in vitro. PMID:24690998
Expression and prognostic significance of the polymeric immunoglobulin receptor in epithelial ovarian cancer. PMID:24568264
Lessons from a BACE1 inhibitor trial: off-site but not off base. PMID:24530026
Inhibiting metastatic breast cancer cell migration via the synergy of targeted, pH-triggered siRNA delivery and chemokine axis blockade. PMID:24467226
IGFBP3, a transcriptional target of homeobox D10, is correlated with the prognosis of gastric cancer. PMID:24386080
Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. PMID:24309898
Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma. PMID:23976835
Integration of cardiac proteome biology and medicine by a specialized knowledgebase. PMID:23965338
An image-based multi-label human protein subcellular localization predictor (iLocator) reveals protein mislocalizations in cancer tissues. PMID:23740749
Variable metastatic potentials correlate with differential plectin and vimentin expression in syngeneic androgen independent prostate cancer cells. PMID:23717685
Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure. PMID:23713052
A texture based pattern recognition approach to distinguish melanoma from non-melanoma cells in histopathological tissue microarray sections. PMID:23690928
Low ERK phosphorylation in cancer-associated fibroblasts is associated with tamoxifen resistance in pre-menopausal breast cancer. PMID:23029174
Finding biomarkers in non-model species: literature mining of transcription factors involved in bovine embryo development. PMID:22931563
The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival. PMID:22772059
Validation of podocalyxin-like protein as a biomarker of poor prognosis in colorectal cancer. PMID:22769594
Production of tissue microarrays, immunohistochemistry staining and digitalization within the human protein atlas. PMID:22688270
Opportunities and challenges for nutritional proteomics in cancer prevention. PMID:22649262
Of mice and men: a comparative study of cancer-associated fibroblasts in mammary carcinoma. PMID:22432595
Discovery of dachshund 2 protein as a novel biomarker of poor prognosis in epithelial ovarian cancer. PMID:22284433
A vision for a biomedical cloud. PMID:22142244
Mechanistic modeling of the effects of myoferlin on tumor cell invasion. PMID:22135466
GLUT 5 is not over-expressed in breast cancer cells and patient breast cancer tissues. PMID:22073218
Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism. PMID:22056600
Antibody-based protein profiling of the human chromosome 21. PMID:22042635
High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression. PMID:21955582
Overview of the matrisome--an inventory of extracellular matrix constituents and functions. PMID:21937732
The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide. PMID:21840852
Overexpression of podocalyxin-like protein is an independent factor of poor prognosis in colorectal cancer. PMID:21829192
RBM3-regulated genes promote DNA integrity and affect clinical outcome in epithelial ovarian cancer. PMID:21804916
Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: an analysis of 215 cases from the Malmö Diet and Cancer Study. PMID:21777469
Toponostics of invasive ductal breast carcinoma: combination of spatial protein expression imaging and quantitative proteome signature analysis. PMID:21738817
Integrated proteomic profiling of cell line conditioned media and pancreatic juice for the identification of pancreatic cancer biomarkers. PMID:21653254
Stromal expression of β-arrestin-1 predicts clinical outcome and tamoxifen response in breast cancer. PMID:21497294
Growth differentiation factor 15: a prognostic marker for recurrence in colorectal cancer. PMID:21468045
ALK1 as an emerging target for antiangiogenic therapy of cancer. PMID:21467543
Disease and phenotype data at Ensembl. PMID:21400687
Characterizations and validations of novel antibodies toward translational research. PMID:21137080
Dual sources of vitronectin in the human lower urinary tract: synthesis by urothelium vs. extravasation from the bloodstream. PMID:21048021
TcoF-DB: dragon database for human transcription co-factors and transcription factor interacting proteins. PMID:20965969
ChemProt: a disease chemical biology database. PMID:20935044
eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease. PMID:20927385
MatrixDB, the extracellular matrix interaction database. PMID:20852260
Caspase-8 as a therapeutic target in cancer. PMID:20817393
Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer. PMID:20727170
Antibody-based proteomics: fast-tracking molecular diagnostics in oncology. PMID:20720569
Minimum information about a protein affinity reagent (MIAPAR). PMID:20622827
A multilevel data integration resource for breast cancer study. PMID:20525248
In-depth proteomic analyses of direct expressed prostatic secretions. PMID:20334419
Primary ex vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis. PMID:19935705
The impact of tissue fixatives on morphology and antibody-based protein profiling in tissues and cells. PMID:19901271
Proteomics, pathway array and signaling network-based medicine in cancer. PMID:19863813
Cancer proteomics--an evolving battlefield. Conference on Cancer Proteomics 2009: Mechanistic Insights, Technological Advances & Molecular Medicine. PMID:19798100
Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology. PMID:19536202
Cancer-associated regulation of alternative splicing. PMID:19448617 -
A genecentric Human Protein Atlas for expression profiles based on antibodies
PubMed citations: 269.
269 articles citing: A genecentric Human Protein Atlas for expression profiles based on antibodies
Multi-Omics Interdisciplinary Research Integration to Accelerate Dementia Biomarker Development (MIRIADE). PMID:35903119
The Correlation Between Immune Invasion and SARS-COV-2 Entry Protein ADAM17 in Cancer Patients by Bioinformatic Analysis. PMID:35720350
Analytical Considerations of Large-Scale Aptamer-Based Datasets for Translational Applications. PMID:35565358
Bilayer Forming Phospholipids as Targets for Cancer Therapy. PMID:35563655
Generation of Thermally Stable Affinity Pairs for Sensitive, Specific Immunoassays. PMID:35482202
NUSAP1 Could be a Potential Target for Preventing NAFLD Progression to Liver Cancer. PMID:35431924
ACAN, MDFI, and CHST1 as Candidate Genes in Gastric Cancer: A Comprehensive Insilco Analysis. PMID:35225482
As a prognostic biomarker of clear cell renal cell carcinoma RUFY4 predicts immunotherapy responsiveness in a PDL1-related manner. PMID:35135552
Integrin-linked kinase (ILK): the known vs. the unknown and perspectives. PMID:35089438
Development of DNA Aptamers to Visualize Release of Mycobacterial Membrane-Derived Extracellular Vesicles in Infected Macrophages. PMID:35056102
Reverse phase protein arrays in acute leukemia: investigative and methodological challenges. PMID:34965151
Nonspecific binding of common anti-CFTR antibodies in ciliated cells of human airway epithelium. PMID:34853321
Prognostic biomarkers for predicting papillary thyroid carcinoma patients at high risk using nine genes of apoptotic pathway. PMID:34767591
PRMT5: An Emerging Target for Pancreatic Adenocarcinoma. PMID:34680285
Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer. PMID:34556703
Expanding the family of extracellular chaperones: Identification of human plasma proteins with chaperone activity. PMID:34553437
Subcellular proteomics. PMID:34549195
Survival-Based Biomarker Module Identification Associated with Oral Squamous Cell Carcinoma (OSCC). PMID:34439992
ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes. PMID:34354120
Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients. PMID:34343625
A novel G-quadruplex aptamer-based spike trimeric antigen test for the detection of SARS-CoV-2. PMID:34188971
Novel Morbillivirus as Putative Cause of Fetal Death and Encephalitis among Swine. PMID:34152961
Considerations on Using Antibodies for Studying the Dynorphins/Kappa Opioid Receptor System. PMID:34085120
Validation of Isoform- and Mutation-Specific RAS Antibodies. PMID:33977472
Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli. PMID:33893305
Epitope-directed monoclonal antibody production using a mixed antigen cocktail facilitates antibody characterization and validation. PMID:33824395
Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19. PMID:33767597
Imaging VIPER-labeled Cellular Proteins by Correlative Light and Electron Microscopy. PMID:33654913
Generation of CoilR Probe Peptides for VIPER-labeling of Cellular Proteins. PMID:33654912
Role of the HSP70 Co-Chaperone SIL1 in Health and Disease. PMID:33557244
Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling. PMID:33531625
Data-Driven Discovery of Molecular Targets for Antibody-Drug Conjugates in Cancer Treatment. PMID:33490264
Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass. PMID:33442236
Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H. PMID:33247206
Systematic Analysis of Protein-Protein and Gene-Environment Interactions to Decipher the Cognitive Mechanisms of Autism Spectrum Disorder. PMID:33165687
Lack of PPARβ/δ-Inactivated SGK-1 Is Implicated in Liver Carcinogenesis. PMID:33083492
A Novel KRAS Antibody Highlights a Regulation Mechanism of Post-Translational Modifications of KRAS during Tumorigenesis. PMID:32887255
Antibody validation for protein expression on tissue slides: a protocol for immunohistochemistry. PMID:32852223
Congruence of Transcription Programs in Adult Stem Cell-Derived Jejunum Organoids and Original Tissue During Long-Term Culture. PMID:32714922
Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells. PMID:32664515
Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling via PHLPP1 in colorectal cancer. PMID:32587773
A proof of concept phase I/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory/relapsed AML patients not eligible for intensive therapy. PMID:32561840
The effect of journal guidelines on the reporting of antibody validation. PMID:32547887
The iron-regulated surface determinant B (IsdB) protein from Staphylococcus aureus acts as a receptor for the host protein vitronectin. PMID:32499371
Recent advances in mass spectrometry based clinical proteomics: applications to cancer research. PMID:32489335
Endometrial profilin 1: a key player in embryo-endometrial crosstalk. PMID:32466630
Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. PMID:32382484
Built-in RNA-mediated chaperone (chaperna) for antigen folding tailored to immunized hosts. PMID:32297972
An array of 60,000 antibodies for proteome-scale antibody generation and target discovery. PMID:32195335
Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. PMID:32193359
Profound intellectual disability caused by homozygous TRAPPC9 pathogenic variant in a man from Malta. PMID:32162493
Validation of Novel Prognostic Biomarkers for Early-Stage Clear-Cell, Endometrioid and Mucinous Ovarian Carcinomas Using Immunohistochemistry. PMID:32133296
Comparison of Prostate-Specific Membrane Antigen Expression Levels in Human Salivary Glands to Non-Human Primates and Rodents. PMID:32074455
Anything You Can Do, I Can Do Better: Can Aptamers Replace Antibodies in Clinical Diagnostic Applications? PMID:31801185
In silico approach to calculate the transcript capacity. PMID:31610627
A Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensics. PMID:31581533
Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian carcinomas. PMID:31533654
Generating Single Cell-Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9. PMID:31503414
HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. PMID:31500569
A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. PMID:31494632
Divide and conquer: two stem cell populations in squamous epithelia, reserves and the active duty forces. PMID:31451683
Plug-and-Play Protein Modification Using Homology-Independent Universal Genome Engineering. PMID:31272828
Dissecting the expression landscape of cytochromes P450 in hepatocellular carcinoma: towards novel molecular biomarkers. PMID:31258835
Klotho: An Elephant in Aging Research. PMID:30843026
Isolating pulmonary microvascular endothelial cells ex vivo: Implications for pulmonary arterial hypertension, and a caution on the use of commercial biomaterials. PMID:30811450
If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease. PMID:30775245
The 3rd Antibody Validation meeting: Bath UK 20-21 st September 2018. PMID:30647913
miRNAmotif-A Tool for the Prediction of Pre-miRNA⁻Protein Interactions. PMID:30562930
A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages. PMID:30333026
Enhanced validation of antibodies for research applications. PMID:30297845
Chronic methamphetamine self-administration dysregulates 5-HT2A and mGlu2 receptor expression in the rat prefrontal and perirhinal cortex: Comparison to chronic phencyclidine and MK-801. PMID:30240581
Single-cell mobility shift electrophoresis reports protein localization to the cell membrane. PMID:30234203
Recent advances in the understanding and treatment of acute myeloid leukemia. PMID:30135719
Autocrine Fibronectin Inhibits Breast Cancer Metastasis. PMID:29934326
Introducing the Affinity Binder Knockdown Initiative⿿A public⿿private partnership for validation of affinity reagents. PMID:29900101
Dying cells expose a nuclear antigen cross-reacting with anti-PD-1 monoclonal antibodies. PMID:29892077
C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases. PMID:29775578
Identification of differential expression lncRNAs in gastric cancer using transcriptome sequencing and bioinformatics analyses. PMID:29693709
Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. PMID:29686080
Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia. PMID:29527516
Overexpressed genes in malignant pleural mesothelioma: implications in clinical management. PMID:29507807
Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. PMID:29323137
Protein purification and analysis: next generation Western blotting techniques. PMID:28974114
Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. PMID:28951536
Authentication of collagen VI antibodies. PMID:28755659
The ABCs of finding a good antibody: How to find a good antibody, validate it, and publish meaningful data. PMID:28713558
The m6A pathway facilitates sex determination in Drosophila. PMID:28675155
KIBRA attains oncogenic activity by repressing RASSF1A. PMID:28664913
Affimer proteins are versatile and renewable affinity reagents. PMID:28654419
Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing. PMID:28595269
Design and operation of an automated high-throughput monoclonal antibody facility. PMID:28510179
Family with sequence similarity 13C (FAM13C) overexpression is an independent prognostic marker in prostate cancer. PMID:28415558
"Omics"-Informed Drug and Biomarker Discovery: Opportunities, Challenges and Future Perspectives. PMID:28248238
A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer. PMID:28169991
Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells. PMID:28121627
Physiologically-based modeling to predict the clinical behavior of monoclonal antibodies directed against lymphocyte antigens. PMID:27892793
Comparative analysis of housekeeping and tissue-specific driver nodes in human protein interaction networks. PMID:27612563
TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions. PMID:27609421
m(6)A RNA methylation promotes XIST-mediated transcriptional repression. PMID:27602518
The CD47 "don't eat me signal" is highly expressed in human ovarian cancer. PMID:27569584
Global profiling of alternative RNA splicing events provides insights into molecular differences between various types of hepatocellular carcinoma. PMID:27565572
Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues. PMID:27454740
Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks. PMID:27403431
H11/HSPB8 Restricts HIV-2 Vpx to Restore the Anti-Viral Activity of SAMHD1. PMID:27379031
Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies. PMID:27377311
Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer. PMID:27371729
Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives. PMID:27316347
Predicting Ovarian Cancer Patients' Clinical Response to Platinum-Based Chemotherapy by Their Tumor Proteomic Signatures. PMID:27312948
Current state of the art for enhancing urine biomarker discovery. PMID:27232439
Hepatitis C virus and neurological damage. PMID:27134702
Quality Issues of Research Antibodies. PMID:27013861
Integrin signalling regulates YAP and TAZ to control skin homeostasis. PMID:26989177
In silico and experimental analyses predict the therapeutic value of an EZH2 inhibitor GSK343 against hepatocellular carcinoma through the induction of metallothionein genes. PMID:26973856
Antibody Engineering & Therapeutics, the annual meeting of The Antibody Society December 7-10, 2015, San Diego, CA, USA. PMID:26909869
The intestinal distribution pattern of appetite- and glucose regulatory peptides in mice, rats and pigs. PMID:26830025
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer. PMID:26771841
S-100 Negative Granular Cell Tumor of the Oral Cavity. PMID:26643916
Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants. PMID:26633466
Oligonucleotide aptamers: A next-generation technology for the capture and detection of circulating tumor cells. PMID:26631715
Research antibodies: do not use them to stain your reputation. PMID:26628686
Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells. PMID:26609053
The potential role of PHF6 as an oncogene: a genotranscriptomic/proteomic meta-analysis. PMID:26561469
Immunocapture strategies in translational proteomics. PMID:26558424
Evaluating markers of epithelial-mesenchymal transition to identify cancer patients at risk for metastatic disease. PMID:26507436
Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions. PMID:26483192
Microtubule Associated Protein 1b (MAP1B) Is a Marker of the Microtubular Cytoskeleton in Podocytes but Is Not Essential for the Function of the Kidney Filtration Barrier in Mice. PMID:26448484
Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins. PMID:26437229
The European antibody network's practical guide to finding and validating suitable antibodies for research. PMID:26418356
A cytoplasmic C-terminal fragment of Syndecan-1 is generated by sequential proteolysis and antagonizes Syndecan-1 dependent lung tumor cell migration. PMID:26378057
A High Through-put Platform for Recombinant Antibodies to Folded Proteins. PMID:26290498
Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS). PMID:26287535
A Multi-Breed Genome-Wide Association Analysis for Canine Hypothyroidism Identifies a Shared Major Risk Locus on CFA12. PMID:26261983
High-Level HOOK3 Expression Is an Independent Predictor of Poor Prognosis Associated with Genomic Instability in Prostate Cancer. PMID:26230842
Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia. PMID:26137202
Emergent Properties of the Metaphase Spindle. PMID:26134313
Reproducibility crisis: Blame it on the antibodies. PMID:25993940
MyProteinNet: build up-to-date protein interaction networks for organisms, tissues and user-defined contexts. PMID:25990735
A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation. PMID:25912030
Generating Recombinant Antibodies against Putative Biomarkers of Retinal Injury. PMID:25902199
IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression. PMID:25848980
Quantitative tandem mass-spectrometry of skin tissue reveals putative psoriatic arthritis biomarkers. PMID:25678896
Reproducibility: Standardize antibodies used in research. PMID:25652980
Characterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach. PMID:25530170
Epigenetics in the hematologic malignancies. PMID:25472952
Mitochondrial targets for pharmacological intervention in human disease. PMID:25367773
Hidden treasures in "ancient" microarrays: gene-expression portrays biology and potential resistance pathways of major lung cancer subtypes and normal tissue. PMID:25325012
Identification of psoriatic arthritis mediators in synovial fluid by quantitative mass spectrometry. PMID:25097465
A unique four-hub protein cluster associates to glioblastoma progression. PMID:25050814
Many local pattern texture features: which is better for image-based multilabel human protein subcellular localization classification? PMID:25050396
Comparative analysis of human tissue interactomes reveals factors leading to tissue-specific manifestation of hereditary diseases. PMID:24921629
Prioritization of cancer marker candidates based on the immunohistochemistry staining images deposited in the human protein atlas. PMID:24303032
Detection of the human endogenous retrovirus ERV3-encoded Env-protein in human tissues using antibody-based proteomics. PMID:24262892
FHOD1, a formin upregulated in epithelial-mesenchymal transition, participates in cancer cell migration and invasion. PMID:24086398
DNA sequencing methods in human genetics and disease research. PMID:24049638
Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells. PMID:24040395
Graft-versus-host disease biomarkers: omics and personalized medicine. PMID:23959582
Finding the right antibody for the job. PMID:23900250
Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction. PMID:23675462
Knockdown of PPAR δ gene promotes the growth of colon cancer and reduces the sensitivity to bevacizumab in nude mice model. PMID:23593291
A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis. PMID:23334424
Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential. PMID:23288492
Parallel immunizations of rabbits using the same antigen yield antibodies with similar, but not identical, epitopes. PMID:23284606
Contextualization procedure and modeling of monocyte specific TLR signaling. PMID:23236359
Multiscale integration of -omic, imaging, and clinical data in biomedical informatics. PMID:23231990
Automated analysis and reannotation of subcellular locations in confocal images from the Human Protein Atlas. PMID:23226299
Retinoid differentiation therapy for common types of acute myeloid leukemia. PMID:23213553
The TissueNet database of human tissue protein-protein interactions. PMID:23193266
Discovery and validation of graft-versus-host disease biomarkers. PMID:23165480
Expression of the coiled coil domain containing protein 116 in the pancreatic islets and endocrine pancreatic tumors. PMID:23072936
Improving international research with clinical specimens: 5 achievable objectives. PMID:22998582
Selfish spermatogonial selection: evidence from an immunohistochemical screen in testes of elderly men. PMID:22879958
Potassium channel KIR4.1 as an immune target in multiple sclerosis. PMID:22784115
In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers. PMID:22761400
Transcriptional response of BALB/c mouse thyroids following in vivo astatine-211 exposure reveals distinct gene expression profiles. PMID:22697397
Production of tissue microarrays, immunohistochemistry staining and digitalization within the human protein atlas. PMID:22688270
Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. PMID:22675468
Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT. PMID:22615553
Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). PMID:22611424
Breaking the LSD1/KDM1A addiction: therapeutic targeting of the epigenetic modifier in AML. PMID:22516254
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. PMID:22406747
SACK-expanded hair follicle stem cells display asymmetric nuclear Lgr5 expression with non-random sister chromatid segregation. PMID:22355691
Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. PMID:22307071
Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women. PMID:22277732
Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients. PMID:22260418
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. PMID:22231558
The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer. PMID:22194470
Profiling of autoantibodies in IgA nephropathy, an integrative antibiomics approach. PMID:22157707
Hepatitis C virus infects the endothelial cells of the blood-brain barrier. PMID:22138189
Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase. PMID:22079122
Sensitive single-molecule protein quantification and protein complex detection in a microarray format. PMID:22038904
Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis. PMID:22037942
The Histone Database: an integrated resource for histones and histone fold-containing proteins. PMID:22025671
Regulation of the C. elegans molt by pqn-47. PMID:21989027
A Protein Epitope Signature Tag (PrEST) library allows SILAC-based absolute quantification and multiplexed determination of protein copy numbers in cell lines. PMID:21964433
Expression profiling of autism candidate genes during human brain development implicates central immune signaling pathways. PMID:21935439
Generation of monospecific antibodies based on affinity capture of polyclonal antibodies. PMID:21898641
Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes. PMID:21843636
A resource for discovering specific and universal biomarkers for distributed stem cells. PMID:21818293
The human proteome project: current state and future direction. PMID:21742803
OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia. PMID:21706474
Keratin 19 epithelial patterns in cirrhotic stroma parallel hepatocarcinogenesis. PMID:21704007
Secretome-based identification of ULBP2 as a novel serum marker for pancreatic cancer detection. PMID:21625447
Autoantigen discovery with a synthetic human peptidome. PMID:21602805
Gamma interferon modulates myogenesis through the major histocompatibility complex class II transactivator, CIITA. PMID:21576360
A roadmap to generate renewable protein binders to the human proteome. PMID:21572409
Wnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells. PMID:21494638
Role of complement cascade in abdominal aortic aneurysms. PMID:21493888
Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation. PMID:21478550
Functional characterization of peroxisome proliferator-activated receptor-β/δ expression in colon cancer. PMID:21400612
Progress in mining the human proteome for disease applications. PMID:21375461
Overview: the maturing of proteomics in cardiovascular research. PMID:21335431
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. PMID:21329510
Detecting protein-protein interactions in vesicular stomatitis virus using a cytoplasmic yeast two hybrid system. PMID:21320532
Charting a course for genomic medicine from base pairs to bedside. PMID:21307933
Do cell junction protein mutations cause an airway phenotype in mice or humans? PMID:21297078
Calcium/NFAT signalling promotes early nephrogenesis. PMID:21295565
Multiplexed protein analysis using encoded antibody-conjugated microbeads. PMID:21247950
Identification of MST1/STK4 and SULF1 proteins as autoantibody targets for the diagnosis of colorectal cancer by using phage microarrays. PMID:21228115
Phage display for the generation of antibodies for proteome research, diagnostics and therapy. PMID:21221060
Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. PMID:21220695
Global expression of cell surface proteins in embryonic stem cells. PMID:21209962
Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability. PMID:21209843
Defining the transcriptome and proteome in three functionally different human cell lines. PMID:21179022
Towards a knowledge-based Human Protein Atlas. PMID:21139605
Analysis of transcript and protein overlap in a human osteosarcoma cell line. PMID:21126332
Sugar transporters for intercellular exchange and nutrition of pathogens. PMID:21107422
CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. PMID:21098087
Laminin database: a tool to retrieve high-throughput and curated data for studies on laminins. PMID:21087995
Dual sources of vitronectin in the human lower urinary tract: synthesis by urothelium vs. extravasation from the bloodstream. PMID:21048021
Subdivision of the MDR superfamily of medium-chain dehydrogenases/reductases through iterative hidden Markov model refinement. PMID:20979641
Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions. PMID:20959820
Patronin regulates the microtubule network by protecting microtubule minus ends. PMID:20946984
Granulovacuolar degeneration (GVD) bodies of Alzheimer's disease (AD) resemble late-stage autophagic organelles. PMID:20946470
Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2. PMID:20863412
In situ proteomic analysis of human breast cancer epithelial cells using laser capture microdissection: annotation by protein set enrichment analysis and gene ontology. PMID:20739354
The grand challenge to decipher the cancer proteome. PMID:20733593
Antibody-based proteomics: fast-tracking molecular diagnostics in oncology. PMID:20720569
Toward next generation plasma profiling via heat-induced epitope retrieval and array-based assays. PMID:20682762
Gene expression analysis after receptor tyrosine kinase activation reveals new potential melanoma proteins. PMID:20663135
Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. PMID:20639884
Stress signaling by Tec tyrosine kinase in the ischemic myocardium. PMID:20543088
Hepatitis C virus infection of neuroepithelioma cell lines. PMID:20538002
Measurement of single-cell dynamics. PMID:20535203
Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787. PMID:20516370
Bioinformatic identification and characterization of human endothelial cell-restricted genes. PMID:20509943
QuickGO: a user tutorial for the web-based Gene Ontology browser. PMID:20157483
Protein subcellular localization profiling of breast cancer cells by dissociable antibody microarray staining. PMID:20127686
A gene-centric human proteome project: HUPO--the Human Proteome organization. PMID:20124355
Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. PMID:20068171
The SP-C promoter facilitates alveolar type II epithelial cell-specific plasmid nuclear import and gene expression. PMID:20054353
Use of proteomics in radiobiological research: current state of the art. PMID:20049610
A global view of protein expression in human cells, tissues, and organs. PMID:20029370
Network-based Identification of novel cancer genes. PMID:19959820
The impact of tissue fixatives on morphology and antibody-based protein profiling in tissues and cells. PMID:19901271
The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells. PMID:19901269
Proteomics, pathway array and signaling network-based medicine in cancer. PMID:19863813
Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature. PMID:19837982
Cancer proteomics--an evolving battlefield. Conference on Cancer Proteomics 2009: Mechanistic Insights, Technological Advances & Molecular Medicine. PMID:19798100
Negative regulators of insulin signaling revealed in a genome-wide functional screen. PMID:19727444
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. PMID:19715320
A community standard format for the representation of protein affinity reagents. PMID:19674966
NDRG4 is required for cell cycle progression and survival in glioblastoma cells. PMID:19592488
Contributions of quantitative proteomics to understanding membrane microdomains. PMID:19578161
Cardiovascular proteomics: implications for clinical applications. PMID:19389553
The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. PMID:19371741
Development of reverse phase protein microarrays for the validation of clusterin, a mid-abundant blood biomarker. PMID:19348683
TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. PMID:19129465
Loss of Rap1GAP in papillary thyroid cancer. PMID:19066305
G2Cdb: the Genes to Cognition database. PMID:18984621 -
Transcriptomics resources of human tissues and organs
PubMed citations: 49.
49 articles citing: Transcriptomics resources of human tissues and organs
Dynamic human liver proteome atlas reveals functional insights into disease pathways. PMID:35579278
A High-Quality Haplotype-Resolved Genome of Common Bermudagrass (Cynodon dactylon L.) Provides Insights Into Polyploid Genome Stability and Prostrate Growth. PMID:35548270
Oligogenic heterozygous inheritance of sperm abnormalities in mouse. PMID:35451961
Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells. PMID:34999972
Mass Spectrometry-Based Proteomics Reveal Alcohol Dehydrogenase 1B as a Blood Biomarker Candidate to Monitor Acetaminophen-Induced Liver Injury. PMID:34681731
Targeting the Transcriptome Through Globally Acting Components. PMID:34603400
Surfaceome Profiling of Rhabdomyosarcoma Reveals B7-H3 as a Mediator of Immune Evasion. PMID:34572755
Organ-Specific Transcriptome Analysis Identifies Candidate Genes Involved in the Stem Specialization of Bermudagrass (Cynodon dactylon L.). PMID:34249097
The origins and genetic interactions of KRAS mutations are allele- and tissue-specific. PMID:33753749
Reflections on the HUPO Human Proteome Project, the Flagship Project of the Human Proteome Organization, at 10 Years. PMID:33640492
A Trans-Omics Comparison Reveals Common Gene Expression Strategies in Four Model Organisms and Exposes Similarities and Differences between Them. PMID:33562654
Melanoma Single-Cell Biology in Experimental and Clinical Settings. PMID:33535416
Combined RNA/tissue profiling identifies novel Cancer/testis genes. PMID:33426787
The Human Protein Atlas-Spatial localization of the human proteome in health and disease. PMID:33146890
The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues. PMID:33008593
The protein expression profile of ACE2 in human tissues. PMID:32715618
A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells. PMID:32669955
Edgetic perturbation signatures represent known and novel cancer biomarkers. PMID:32152446
Mechanisms of tissue and cell-type specificity in heritable traits and diseases. PMID:31913361
On the inconsistent treatment of gene-protein-reaction rules in context-specific metabolic models. PMID:31722383
Novel functional proteins coded by the human genome discovered in metastases of melanoma patients. PMID:31599373
Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. PMID:31553721
LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway. PMID:30791942
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues. PMID:30777892
Genomic evidence of Y chromosome microchimerism in the endometrium during endometriosis and in cases of infertility. PMID:30760267
Neurons with Complex Karyotypes Are Rare in Aged Human Neocortex. PMID:30673605
The Importance of Biologic Knowledge and Gene Expression Context for Genomic Data Interpretation. PMID:30619486
How many cadherins do human endothelial cells express? PMID:30552441
Lost in Translation: Traversing the Complex Path from Genomics to Therapeutics in Autism Spectrum Disorder. PMID:30359605
Human Urinary mRNA as a Biomarker of Cardiovascular Disease. PMID:30354328
Tissue-Specific Profiling of Oxidative Stress-Associated Transcriptome in a Healthy Mouse Model. PMID:30326626
Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome. PMID:30065722
ATP binding cassette (ABC) transporters: expression and clinical value in glioblastoma. PMID:29520610
The Gene-Centric Content Management System and Its Application for Cognitive Proteomics. PMID:29473895
Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density. PMID:29444691
High-resolution spatiotemporal transcriptome mapping of tomato fruit development and ripening. PMID:29371663
An RNA-Seq atlas of gene expression in mouse and rat normal tissues. PMID:29231921
Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project. PMID:28853897
Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome. PMID:28845240
Network analyses identify liver-specific targets for treating liver diseases. PMID:28827398
New Challenges to Study Heterogeneity in Cancer Redox Metabolism. PMID:28744456
Proteomics and metabolomics in ageing research: from biomarkers to systems biology. PMID:28698311
Relevance of tissue specific subunit expression in channelopathies. PMID:28669898
mTFkb: a knowledgebase for fundamental annotation of mouse transcription factors. PMID:28596516
On the effects of alternative optima in context-specific metabolic model predictions. PMID:28557990
Models of global gene expression define major domains of cell type and tissue identity. PMID:28426095
Functional Genomics, Genetics, and Bioinformatics 2016. PMID:27995138
Metrics for the Human Proteome Project 2016: Progress on Identifying and Characterizing the Human Proteome, Including Post-Translational Modifications. PMID:27487407
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance. PMID:27345421 - http://dx.doi.org/10.1126/science.1260419
Tags:
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More detailed information about this field from each metasource.
antibody
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
biological imaging
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
blood
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
brain
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
cancer
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
cell line
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
cellular localization
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
gene expression
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
mass spectrometry assay
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
medical imaging
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
molecular structure
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
protein
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
protein expression
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
protein localization
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
structure
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
tissue
metasource: Fairsharing.org
version: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
rna
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
cell biology
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
cell lines
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
histology
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
human
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
pathology
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
proteomics
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
gene and protein families
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
oncology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
structural biology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
protein targeting and localisation
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
model organisms
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
humans
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
Tags
More detailed information about this field from each metasource.
antibody
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
biological imaging
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
blood
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
brain
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
cancer
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: re3data.org
version: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
cell line
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
cellular localization
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
gene expression
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:27:04.256341
mass spectrometry assay
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
medical imaging
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
molecular structure
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
protein
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
protein expression
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
protein localization
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
structure
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
tissue
metasource: Fairsharing.orgversion: FAIRsharing.org: HPA; Human Protein Atlas; DOI: https://doi.org/10.25504/FAIRsharing.j0t0pe; Last edited: March 10, 2021, 8:35 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
rna
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
cell biology
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
cell lines
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
histology
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
human
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
pathology
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
proteomics
metasource: re3data.orgversion: re3data.org: The Human Protein Atlas; editing status 2022-02-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R35S55 last accessed: 2022-11-04
gene and protein families
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:04.256341
oncology
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:04.256341
structural biology
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:04.256341
protein targeting and localisation
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:04.256341
model organisms
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:04.256341
humans
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:27:04.256341
antibody biological imaging blood brain cancer cell line cellular localization gene expression mass spectrometry assay medical imaging molecular structure protein protein expression protein localization structure tissue rna cell biology cell lines histology human pathology proteomics gene and protein families oncology structural biology protein targeting and localisation model organisms humans
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