Human Reference Protein Interactome Mapping Project

Other names: HuRI

The Human Reference Protein Interactome Mapping Project (HuRI) is a repository, created by the Center for Cancer Systems Biology (CCSB) at Dana-Farber Cancer Institute, which stores the data from the ongoing work on the first complete reference map of the human protein-protein interactome network. All pairwise combinations of human protein-coding genes are systematically being interrogated to identify which are involved in binary protein-protein interactions. HuRI has grown in several distinct stages primarily defined by the number of human protein-coding genes amenable to screening for which at least one Gateway-cloned Open Reading Frame (ORF) was available at the time of the project. Three proteome-scale human PPI datasets are available via HuRI. PPI datasets generated in systematic screens on smaller sets of our human ORF collection have also been included. Also included are all PPIs identified in screens using different protein isoforms from the same gene as generated by alternative splicing.



alternative splicing high-throughput screening interactome protein interaction

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