Game-theoretic link relevance indexing on genome-wide expression dataset identifies putative salient genes with potential etiological and diapeutics role in colorectal cancer.
PMID:35927308
Repurposing Drugs via Network Analysis: Opportunities for Psychiatric Disorders.
PMID:35890359
A Method for Bridging Population-Specific Genotypes to Detect Gene Modules Associated with Alzheimer's Disease.
PMID:35883662
Comparative Analysis of Gene Correlation Networks of Breast Cancer Patients Based on Mutations in TP53.
PMID:35883535
Active ingredients and molecular targets of Taraxacum mongolicum against hepatocellular carcinoma: network pharmacology, molecular docking, and molecular dynamics simulation analysis.
PMID:35873910
Network Pharmacology-Based Strategy to Reveal the Mechanism of Cassiae Semen against Cataracts.
PMID:35860180
Total Flavonoids of Drynariae Rhizoma Improve Glucocorticoid-Induced Osteoporosis of Rats: UHPLC-MS-Based Qualitative Analysis, Network Pharmacology Strategy and Pharmacodynamic Validation.
PMID:35846330
A Review of Traditional Chinese Medicine, Buyang Huanwu Decoction for the Treatment of Cerebral Small Vessel Disease.
PMID:35844225
Novel Functional eQTL-SNPs Associated With Susceptibility to Mycoplasma pneumoniae Pneumonia in Children.
PMID:35836993
Downregulated Copper Homeostasis-Related Gene FOXO1 as a Novel Indicator for the Prognosis and Immune Response of Breast Cancer.
PMID:35800988
Systems Pharmacology and Molecular Docking Reveals the Mechanisms of Nux Vomica for the Prevention of Myasthenia Gravis.
PMID:35795289
Distinct Roles of NANOS1 and NANOS3 in the Cell Cycle and NANOS3-PUM1-FOXM1 Axis to Control G2/M Phase in a Human Primordial Germ Cell Model.
PMID:35743036
Pharmacological mechanisms of sodium-glucose co-transporter 2 inhibitors in heart failure with preserved ejection fraction.
PMID:35689186
The Brain Research Hotspot Database (BRHD): A Panoramic Database of the Latest Hotspots in Brain Research.
PMID:35625024
Biomarker Candidates for Tumors Identified from Deep-Profiled Plasma Stem Predominantly from the Low Abundant Area.
PMID:35605973
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease.
PMID:35572351
Discovery of Novel Drug Candidates for Alzheimer's Disease by Molecular Network Modeling.
PMID:35493947
Network Pharmacology Analysis of Huangqi Jianzhong Tang Targets in Gastric Cancer.
PMID:35462892
Molecular Evolutionary Rate Predicts Intraspecific Genetic Polymorphism and Species-Specific Selection.
PMID:35456514
Transcriptomic Analysis of Fumarate Compounds Identifies Unique Effects of Isosorbide Di-(Methyl Fumarate) on NRF2, NF-kappaB and IRF1 Pathway Genes.
PMID:35455458
Exploring the Mechanism through which Phyllanthus emblica L. Extract Exerts Protective Effects against Acute Gouty Arthritis: A Network Pharmacology Study and Experimental Validation.
PMID:35449811
RGMQL: scalable and interoperable computing of heterogeneous omics big data and metadata in R/Bioconductor.
PMID:35392801
Exploring Active Compounds and Mechanisms of Angong Niuhuang Wan on Ischemic Stroke Based on Network Pharmacology and Molecular Docking.
PMID:35388303
Genetics of osteopontin in patients with chronic kidney disease: The German Chronic Kidney Disease study.
PMID:35385482
Diseases 2.0: a weekly updated database of disease-gene associations from text mining and data integration.
PMID:35348648
Revealing Calcium Signaling Pathway as Novel Mechanism of Danhong Injection for Treating Acute Myocardial Infarction by Systems Pharmacology and Experiment Validation.
PMID:35281886
Network Pharmacology Study to Reveal the Potentiality of a Methanol Extract of Caesalpinia sappan L. Wood against Type-2 Diabetes Mellitus.
PMID:35207564
Network pharmacology analysis and molecular docking to unveil the potential mechanisms of San-Huang-Chai-Zhu formula treating cholestasis.
PMID:35196362
BCL2L1 is identified as a target of naringenin in regulating ovarian cancer progression.
PMID:35184257
The Material Basis and Mechanism of Xuefu Zhuyu Decoction in Treating Stable Angina Pectoris and Unstable Angina Pectoris.
PMID:35140797
A Similarity-Based Method for Predicting Enzymatic Functions in Yeast Uncovers a New AMP Hydrolase.
PMID:35123996
Field cancerization profile-based prognosis signatures lead to more robust risk evaluation in hepatocellular carcinoma.
PMID:35118360
Predicting Coupled Herbs for the Treatment of Hypertension Complicated with Coronary Heart Disease in Real-World Data Based on a Complex Network and Machine Learning.
PMID:35103067
Modular characteristics and the mechanism of Chinese medicine's treatment of gastric cancer: a data mining and pharmacology-based identification.
PMID:35071471
Impact of Qi-Invigorating Traditional Chinese Medicines on Diffuse Large B Cell Lymphoma Based on Network Pharmacology and Experimental Validation.
PMID:34955857
Achenbach's Syndrome Revisited: The Paroxysmal Finger Hematoma May Have a Genetic Link.
PMID:34934323
The mining and construction of a knowledge base for gene-disease association in mitochondrial diseases.
PMID:34903783
Using the Symptom Patient Similarity Network to Explore the Difference between the Chinese and Western Medicine Pathways of Ischemic Stroke and its Comorbidities.
PMID:34899950
Uncovering Bupi Yishen Formula Pharmacological Mechanisms Against Chronic Kidney Disease by Network Pharmacology and Experimental Validation.
PMID:34867380
Potential Mechanism of Dingji Fumai Decoction Against Atrial Fibrillation Based on Network Pharmacology, Molecular Docking, and Experimental Verification Integration Strategy.
PMID:34859062
A cross-species approach for the identification of Drosophila male sterility genes.
PMID:34849808
Diversity and molecular network patterns of symptom phenotypes.
PMID:34848731
BDdb: a comprehensive platform for exploration and utilization of birth defect multi-omics data.
PMID:34736471
Knowledge-based approaches to drug discovery for rare diseases.
PMID:34718207
A holistic miRNA-mRNA module discovery.
PMID:34703956
Deep post-GWAS analysis identifies potential risk genes and risk variants for Alzheimer's disease, providing new insights into its disease mechanisms.
PMID:34654853
Targeting cathepsins: A potential link between COVID-19 and associated neurological manifestations.
PMID:34604555
MMP1 and MMP9 are potential prognostic biomarkers and targets for uveal melanoma.
PMID:34587931
Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing.
PMID:34535131
Uncovering the Mechanisms and Molecular Targets of Weibing Formula 1 against Gastritis: Coupling Network Pharmacology with GEO Database.
PMID:34471638
Tetrandrine may treat membranous glomerulopathy via P13K/Akt signaling pathway regulation: therapeutic mechanism validation using Heymann nephritis rat model.
PMID:34463195
Insights into the molecular mechanisms of Huangqi decoction on liver fibrosis via computational systems pharmacology approaches.
PMID:34301291
Network Pharmacological Analysis and Experimental Validation of the Mechanisms of Action of Si-Ni-San Against Liver Fibrosis.
PMID:34276360
Role of Plant-Derived Natural Compounds in Experimental Autoimmune Encephalomyelitis: A Review of the Treatment Potential and Development Strategy.
PMID:34262447
Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
PMID:34250083
Identifying ceRNA Networks Associated With the Susceptibility and Persistence of Atrial Fibrillation Through Weighted Gene Co-Expression Network Analysis.
PMID:34249084
Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation.
PMID:34244696
Identification of viral-mediated pathogenic mechanisms in neurodegenerative diseases using network-based approaches.
PMID:34237135
A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine.
PMID:34221858
Summarizing the Effective Herbs for the Treatment of Hypertensive Nephropathy by Complex Network and Machine Learning.
PMID:34194519
Cytoplasmic long noncoding RNAs are differentially regulated and translated during human neuronal differentiation.
PMID:34193551
Assembling Disease Networks From Causal Interaction Resources.
PMID:34178043
Constructing High-Fidelity Phenotype Knowledge Graphs for Infectious Diseases With a Fine-Grained Semantic Information Model: Development and Usability Study.
PMID:34128811
A Study to Decipher the Potential Effects of Butylphthalide against Central Nervous System Diseases Based on Network Pharmacology and Molecular Docking Integration Strategy.
PMID:34035826
Mapping OMIM Disease-Related Variations on Protein Domains Reveals an Association Among Variation Type, Pfam Models, and Disease Classes.
PMID:34026820
Siteng Fang Reverses Multidrug Resistance in Gastric Cancer: A Network Pharmacology and Molecular Docking Study.
PMID:34026648
An overview of graph databases and their applications in the biomedical domain.
PMID:34003247
Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris.
PMID:34003106
EnRank: An Ensemble Method to Detect Pulmonary Hypertension Biomarkers Based on Feature Selection and Machine Learning Models.
PMID:33986767
Deciphering Pharmacological Mechanism of Buyang Huanwu Decoction for Spinal Cord Injury by Network Pharmacology Approach.
PMID:33976706
Not So Dead Genes-Retrocopies as Regulators of Their Disease-Related Progenitors and Hosts.
PMID:33921034
Exploring the Pharmacological Mechanism of Duhuo Jisheng Decoction in Treating Osteoporosis Based on Network Pharmacology.
PMID:33880122
GPCards: An integrated database of genotype-phenotype correlations in human genetic diseases.
PMID:33868597
Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures.
PMID:33847263
Network bioinformatics analysis provides insight into drug repurposing for COVID-19.
PMID:33817623
Identification of New miRNA-mRNA Networks in the Development of Non-syndromic Cleft Lip With or Without Cleft Palate.
PMID:33732700
Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation.
PMID:33645621
The novel roles of virus infection-associated gene CDKN1A in chemoresistance and immune infiltration of glioblastoma.
PMID:33621203
COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders.
PMID:33521688
Network Pharmacology-Based Analysis on the Mechanism of Action of Ephedrae Herba-Cinnamomi Ramulus Couplet Medicines in the Treatment for Psoriasis.
PMID:33513128
A bottom-up approach to creating an ontology for medication indications.
PMID:33484128
A network-based machine-learning framework to identify both functional modules and disease genes.
PMID:33409574
Plasma Exosomal MiRNAs Expression Profile in Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis: Case-Control Study and Analysis of Potential Functions.
PMID:33240042
Network pharmacology, molecular docking integrated surface plasmon resonance technology reveals the mechanism of Toujie Quwen Granules against coronavirus disease 2019 pneumonia.
PMID:33191068
Virtual screening and network pharmacology-based synergistic mechanism identification of multiple components contained in Guanxin V against coronary artery disease.
PMID:33187508
The risk of COVID-19 for pregnant women: Evidences of molecular alterations associated with preeclampsia in SARS-CoV-2 infection.
PMID:33137411
Insights into the mechanism of Arnebia euchroma on leukemia via network pharmacology approach.
PMID:33109189
RNAcentral 2021: secondary structure integration, improved sequence search and new member databases.
PMID:33106848
Clinical Implications of the Genetic Architecture of Dilated Cardiomyopathy.
PMID:33040239
Systematically Exploring the Antitumor Mechanisms of Core Chinese Herbs on Hepatocellular Carcinoma: A Computational Study.
PMID:33014099
Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets.
PMID:32814578
Investigation on the Mechanism of Qubi Formula in Treating Psoriasis Based on Network Pharmacology.
PMID:32655662
Epigenome-450K-wide methylation signatures of active cigarette smoking: The Young Finns Study.
PMID:32583859
Tamoxifen induces fatty liver disease in breast cancer through the MAPK8/FoxO pathway.
PMID:32508033
Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1).
PMID:32419904
The 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Phenotypes.
PMID:32384786
MACSNVdb: a high-quality SNV database for interspecies genetic divergence investigation among macaques.
PMID:32367112
A Network Pharmacology Study on the Mechanisms of the Herbal Extract, Christina Loosestrife, for the Treatment of Nephrolithiasis.
PMID:32241963
Toward Development of the Male Pill: A Decade of Potential Non-hormonal Contraceptive Targets.
PMID:32161754
ncRPheno: a comprehensive database platform for identification and validation of disease related noncoding RNAs.
PMID:32122231
Disentangling the genetics of sarcopenia: prioritization of NUDT3 and KLF5 as genes for lean mass & HLA-DQB1-AS1 for hand grip strength with the associated enhancing SNPs & a scoring system.
PMID:32093658
Identification of Drug-Disease Associations Using Information of Molecular Structures and Clinical Symptoms via Deep Convolutional Neural Network.
PMID:31998700
Pharmacological Chaperones: A Therapeutic Approach for Diseases Caused by Destabilizing Missense Mutations.
PMID:31940970
Genome analysis and knowledge-driven variant interpretation with TGex.
PMID:31888639
Finding prognostic gene pairs for cancer from patient-specific gene networks.
PMID:31856825
The Western Diet Regulates Hippocampal Microvascular Gene Expression: An Integrated Genomic Analyses in Female Mice.
PMID:31836762
Deep learning for inferring gene relationships from single-cell expression data.
PMID:31822622
A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Kang-Bai-Ling for Treatment of Vitiligo.
PMID:31781265
PCOSBase: a manually curated database of polycystic ovarian syndrome.
PMID:31725861
Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects.
PMID:31705029
RareLSD: a manually curated database of lysosomal enzymes associated with rare diseases.
PMID:31688938
Systematic large-scale meta-analysis identifies miRNA-429/200a/b and miRNA-141/200c clusters as biomarkers for necrotizing enterocolitis in newborn.
PMID:31383782
A Web Tool for Ranking Candidate Drugs Against a Selected Disease Based on a Combination of Functional and Structural Criteria.
PMID:31360332
Clustered microRNAs hsa-miR-221-3p/hsa-miR-222-3p and their targeted genes might be prognostic predictors for hepatocellular carcinoma.
PMID:31258758
Protein-Protein Interaction Network Analysis Reveals Several Diseases Highly Associated with Polycystic Ovarian Syndrome.
PMID:31216618
Bioinformatics analysis of the regulatory lncRNA‑miRNA‑mRNA network and drug prediction in patients with hypertrophic cardiomyopathy.
PMID:31180540
Gene pathogenicity prediction of Mendelian diseases via the random forest algorithm.
PMID:31069506
Analysis of a nanoparticle‑enriched fraction of plasma reveals miRNA candidates for Down syndrome pathogenesis.
PMID:31017260
[From symptom to diagnosis-symptom checkers re-evaluated : Are symptom checkers finally sufficient and accurate to use? An update from the ENT perspective].
PMID:30993374
Prioritization of genes involved in endothelial cell apoptosis by their implication in lymphedema using an analysis of associative gene networks with ANDSystem.
PMID:30871556
Herb Target Prediction Based on Representation Learning of Symptom related Heterogeneous Network.
PMID:30867892
GenCoNet - A Graph Database for the Analysis of Comorbidities by Gene Networks.
PMID:30864352
Analyzing a co-occurrence gene-interaction network to identify disease-gene association.
PMID:30736752
Intronic CNVs and gene expression variation in human populations.
PMID:30677042
GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis.
PMID:30524706
The Chinese herbal formula Fuzheng Quxie Decoction attenuates cognitive impairment and protects cerebrovascular function in SAMP8 mice.
PMID:30519025
Downregulation of exosomal let-7a-5p in dust exposed- workers contributes to lung cancer development.
PMID:30497474
PreMedKB: an integrated precision medicine knowledgebase for interpreting relationships between diseases, genes, variants and drugs.
PMID:30407536
Zika Virus Infection of Human Mesenchymal Stem Cells Promotes Differential Expression of Proteins Linked to Several Neurological Diseases.
PMID:30377986
Heterogeneous network embedding for identifying symptom candidate genes.
PMID:30357378
Simulation of the Dynamics of Primary Immunodeficiencies in B Cells.
PMID:30116248
Computational resources associating diseases with genotypes, phenotypes and exposures.
PMID:30102366
A data-driven, knowledge-based approach to biomarker discovery: application to circulating microRNA markers of colorectal cancer prognosis.
PMID:29872543
Community-driven roadmap for integrated disease maps.
PMID:29688273
A Systems Approach to Refine Disease Taxonomy by Integrating Phenotypic and Molecular Networks.
PMID:29669699
BIOPYDB: A Dynamic Human Cell Specific Biochemical Pathway Database with Advanced Computational Analyses Platform.
PMID:29547394
Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks.
PMID:29504915
Lnc2Catlas: an atlas of long noncoding RNAs associated with risk of cancers.
PMID:29382910
Up-regulated Pro-inflammatory MicroRNAs (miRNAs) in Alzheimer's disease (AD) and Age-Related Macular Degeneration (AMD).
PMID:29302837
PGA: post-GWAS analysis for disease gene identification.
PMID:29300829
Integrated rare variant-based risk gene prioritization in disease case-control sequencing studies.
PMID:29281626
Gene expression profiles indicate tissue-specific obesity regulation changes and strong obesity relevant tissues.
PMID:29151593
PedAM: a database for Pediatric Disease Annotation and Medicine.
PMID:29126123
eRAM: encyclopedia of rare disease annotations for precision medicine.
PMID:29106618
Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills.
PMID:29038583
Formalizing drug indications on the road to therapeutic intent.
PMID:29016968
Characterization of Soft Amyloid Cores in Human Prion-Like Proteins.
PMID:28935930
Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect.
PMID:28830434
eDGAR: a database of Disease-Gene Associations with annotated Relationships among genes.
PMID:28812536