LncRNADisease
A surprising finding in human transcriptome analysis is that protein-coding sequences only account for a small portion of the genome transcripts (1). The majority of the human genome transcripts are noncoding RNAs, in particular, long noncoding RNAs (lncRNAs) (2). In recent years, accumulating studies have revealed that a number of lncRNAs are not transcriptional noise but have important functions. More recently, researchers have attempted to understand the relationships between lncRNAs and diseases. Studies have reported that lncRNA dysfunctions are associated with a broad range of diseases (3), including cancers (4), cardiovascular diseases(5), and neurodegeneration diseases (6). The study of lncRNA-disease associations is becoming one of the most important topics of lncRNAs and diseases. For this reason, a high quality lncRNA-disease association database will be helpful in studying the roles of lncRNAs in diseases but is still not available. In this paper, we describe a long noncoding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease. LncRNADisease database collected and curated ~480 entries of experimentally supported lncRNA-disease associations including 166 diseases. LncRNADisease also curated 478 entries of lncRNA interacting partners at various molecular levels, including protein, RNA, miRNA, and DNA.Moreover, we annotated lncRNA-disease associations with genomic information, sequences, references, and species. We normalized the disease name and the type of lncRNA dysfunction and provided a detailed description for each entry. Finally, we developed a bioinformatic method to predict novel lncRNA-disease associations and integrated the method and the predicted associated diseases of 1, 564 human lncRNAs into the database.
Webpage:
http://www.cuilab.cn/lncrnadisease
Publications:
Tags:
human genes and diseases gene-, system- or disease-specific
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