R31NJMR9 last accessed: 2022-11-04

disgenet
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

Other names: DisGeNET, A knowledge base for disease genomics, disgenet

DisGeNET is a discovery platform containing one of the largest collections available of genes and variants involved in human diseases. DisGeNET integrates data from expert curated repositories, GWAS catalogues, animal models, and the scientific literature, and covers the whole landscape of human diseases. The current version of DisGeNET (v7.0) contains 1,134,942 gene-disease associations (GDAs), between 21,671 genes and 30,170 diseases, disorders, traits, and clinical or abnormal human phenotypes, and 369,554 variant-disease associations (VDAs), between 194,515 variants and 14,155 diseases, traits, and phenotypes. The data are homogeneously annotated with controlled vocabularies and community-driven ontologies. Additionally, several original metrics are provided to assist the prioritization of genotype-phenotype relationships. The information is accessible through a web interface, a Cytoscape App, an RDF SPARQL endpoint, a REST API, and an R package.

Webpage:

http://www.disgenet.org

Licence:

Name: Disgenet Open Database License
URL: http://www.disgenet.org/legal

Publications: (12)

Publications
More detailed information about this field from each metasource.

DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants
PMID: 27924018
metasource: Fairsharing.org
version: FAIRsharing.org: DisGeNET; DisGeNET: a knowledge base for disease genomics; DOI: https://doi.org/10.25504/FAIRsharing.fssydn; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

The DisGeNET knowledge platform for disease genomics: 2019 update
PMID: 31680165
metasource: Fairsharing.org
version: FAIRsharing.org: DisGeNET; DisGeNET: a knowledge base for disease genomics; DOI: https://doi.org/10.25504/FAIRsharing.fssydn; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes
PMID: 25877637
metasource: Fairsharing.org
version: FAIRsharing.org: DisGeNET; DisGeNET: a knowledge base for disease genomics; DOI: https://doi.org/10.25504/FAIRsharing.fssydn; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

DisGeNET: a Cytoscape plugin to visualize, integrate, search and analyze gene-disease networks
PMID: 20861032
metasource: Fairsharing.org
version: FAIRsharing.org: DisGeNET; DisGeNET: a knowledge base for disease genomics; DOI: https://doi.org/10.25504/FAIRsharing.fssydn; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases
PMID: 21695124
metasource: Fairsharing.org
version: FAIRsharing.org: DisGeNET; DisGeNET: a knowledge base for disease genomics; DOI: https://doi.org/10.25504/FAIRsharing.fssydn; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

https://doi.org/10.1016/j.csbj.2021.05.015
metasource: Fairsharing.org
version: FAIRsharing.org: DisGeNET; DisGeNET: a knowledge base for disease genomics; DOI: https://doi.org/10.25504/FAIRsharing.fssydn; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

http://dx.doi.org/10.1093/database/bav028
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

http://dx.doi.org/10.1093/nar/gkw943
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

http://dx.doi.org/10.1093/bioinformatics/btq538
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

http://dx.doi.org/10.1093/bioinformatics/btw214
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

http://dx.doi.org/10.1371/journal.pone.0020284
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

http://dx.doi.org/10.1093/nar/gkz1021
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants PubMed citations: 727.

727 articles citing: DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants

An accurate prediction model of digenic interaction for estimating pathogenic gene pairs of human diseases. PMID:35891796
Pan-cancer integrative analysis of whole-genome De novo somatic point mutations reveals 17 cancer types. PMID:35879674
Identifying Active Compounds and Mechanisms of Citrus changshan-Huyou Y. B. Chang against URTIs-Associated Inflammation by Network Pharmacology in Combination with Molecular Docking. PMID:35873643
Study on the Anti-demyelination Mechanism of Bu-Shen-Yi-Sui Capsule in the Central Nervous System Based on Network Pharmacology and Experimental Verification. PMID:35865997
Comprehensive Assessment of Indian Variations in the Druggable Kinome Landscape Highlights Distinct Insights at the Sequence, Structure and Pharmacogenomic Stratum. PMID:35865963
Prediction of Gastric Cancer-Related Genes Based on the Graph Transformer Network. PMID:35847949
Network pharmacology-based analysis of the effects of puerarin on sarcopenia. PMID:35845507
A systems biology analysis of protein-protein interaction of digestive disorders and Covid-19 virus based on comprehensive gene information. PMID:35845309
Differential gene screening and bioinformatics analysis of epidermal stem cells and dermal fibroblasts during skin aging. PMID:35835980
The Pharmacological Mechanism of Xiyanping Injection for the Treatment of Novel Coronavirus Pneumonia (COVID-19): Based on Network Pharmacology Strategy. PMID:35818408
Sub-GOFA: A tool for Sub-Gene Ontology function analysis in clonal mosaicism using semantic (logical) similarity. PMID:35815201
Network Pharmacology Experiments Show That Emodin Can Exert a Protective Effect on MCAO Rats by Regulating Hif-1α/VEGF-A Signaling. PMID:35811865
Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer's disease risk. PMID:35809216
Transcriptome Profiling of the Dorsomedial Prefrontal Cortex in Suicide Victims. PMID:35806070
Epigenetic Alterations in Cryopreserved Human Spermatozoa: Suspected Potential Functional Defects. PMID:35805194
iPCD: A Comprehensive Data Resource of Regulatory Proteins in Programmed Cell Death. PMID:35805101
Network Pharmacology and Data Mining Approach Reveal the Medication Rule of Traditional Chinese Medicine in the Treatment of Premenstrual Syndrome/Premenstrual Dysphoric Disorder. PMID:35800440
Systems Pharmacology and Molecular Docking Reveals the Mechanisms of Nux Vomica for the Prevention of Myasthenia Gravis. PMID:35795289
Network Pharmacology-Based Strategy to Investigate the Pharmacologic Mechanisms of Coptidis Rhizoma for the Treatment of Alzheimer's Disease. PMID:35795239
Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis. PMID:35792766
SperoPredictor: An Integrated Machine Learning and Molecular Docking-Based Drug Repurposing Framework With Use Case of COVID-19. PMID:35784208
Transcriptome Profiling and Network Analysis Provide Insights Into the Pathogenesis of Vulvar Lichen Sclerosus. PMID:35783265
Global genomic and proteomic analysis indicates co-evolution of Neisseria species and with their human host. PMID:35773545
Qishen Yiqi Dripping Pill Protects Diabetic Nephropathy by Inhibiting the PI3K-AKT Signaling Pathways in Rats. PMID:35754685
Modeling Kaempferol as a Potential Pharmacological Agent for COVID-19/PF Co-Occurrence Based on Bioinformatics and System Pharmacological Tools. PMID:35754492
Differential vulnerability of anterior cingulate cortex cell types to diseases and drugs. PMID:35754044
Network Pharmacology and Bioinformatics Approach Reveals the Multi-Target Pharmacological Mechanism of Fumaria indica in the Treatment of Liver Cancer. PMID:35745580
A Quantitative Proteomic Approach Explores the Possible Mechanisms by Which the Small Molecule Stemazole Promotes the Survival of Human Neural Stem Cells. PMID:35741576
Using BERT to identify drug-target interactions from whole PubMed. PMID:35729494
Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty. PMID:35729321
Integrated Microbiome and Host Transcriptome Profiles Link Parkinson's Disease to Blautia Genus: Evidence From Feces, Blood, and Brain. PMID:35722294
Transcriptome Sequencing Data Reveal LncRNA-miRNA-mRNA Regulatory Network in Calcified Aortic Valve Disease. PMID:35722091
Integrating Network Pharmacology and Experimental Validation to Explore the Key Mechanism of Gubitong Recipe in the Treatment of Osteoarthritis. PMID:35720033
DNA methylation dynamics associated with long-term isolation of simulated space travel. PMID:35712082
Genetic pain loss disorders. PMID:35710757
Multi-view heterogeneous molecular network representation learning for protein-protein interaction prediction. PMID:35710342
A Computational Data Mining Strategy to Identify the Common Genetic Markers of Temporomandibular Joint Disorders and Osteoarthritis. PMID:35707787
Exploring the Effect and Mechanism of Si-Miao-Yong-An Decoction on Abdominal Aortic Aneurysm Based on Mice Experiment and Bioinformatics Analysis. PMID:35685724
Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data. PMID:35680885
Expediting knowledge acquisition by a web framework for Knowledge Graph Exploration and Visualization (KGEV): case studies on COVID-19 and Human Phenotype Ontology. PMID:35655307
Potential biomarkers and molecular mechanisms in preeclampsia progression. PMID:35647297
Detecting Key Functional Components Group and Speculating the Potential Mechanism of Xiao-Xu-Ming Decoction in Treating Stroke. PMID:35646921
Medication Rules in Herbal Medicine for Mild Cognitive Impairment: A Network Pharmacology and Data Mining Study. PMID:35646138
The Brain Research Hotspot Database (BRHD): A Panoramic Database of the Latest Hotspots in Brain Research. PMID:35625024
CancerOmicsNet: a multi-omics network-based approach to anti-cancer drug profiling. PMID:35601606
Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways. PMID:35596156
Exploration of the System-Level Mechanisms of the Herbal Drug FDY003 for Pancreatic Cancer Treatment: A Network Pharmacological Investigation. PMID:35591866
Identifying Alzheimer's genes via brain transcriptome mapping. PMID:35590321
GenePlexus: a web-server for gene discovery using network-based machine learning. PMID:35580053
A network-biology led computational drug repurposing strategy to prioritize therapeutic options for COVID-19. PMID:35578630
Cryptotanshinone Attenuates Amyloid-β42-induced Tau Phosphorylation by Regulating PI3K/Akt/GSK3β Pathway in HT22 Cells. PMID:35575872
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease. PMID:35572351
Andrographolide in atherosclerosis: integrating network pharmacology and in vitro pharmacological evaluation. PMID:35543243
Sparganin A alleviates blood stasis syndrome and its key targets by molecular docking. PMID:35541782
Analyzing and reconciling colocalization and transcriptome-wide association studies from the perspective of inferential reproducibility. PMID:35523146
Systematic Elaboration of the Pharmacological Targets and Potential Mechanisms of ZhiKe GanCao Decoction for Preventing and Delaying Intervertebral Disc Degeneration. PMID:35497916
An integrated network representation of multiple cancer-specific data for graph-based machine learning. PMID:35487924
Exploration in the Therapeutic and Multi-Target Mechanism of Ketamine on Cerebral Ischemia Based on Network Pharmacology and Molecular Docking. PMID:35480991
Mechanism of Jujube (Ziziphus jujuba Mill.) Fruit in the Appetite Regulation Based on Network Pharmacology and Molecular Docking Method. PMID:35480085
Icariin: A Potential Molecule for Treatment of Knee Osteoarthritis. PMID:35479319
Novel Protein-Protein Interactions Highlighting the Crosstalk between Hypoplastic Left Heart Syndrome, Ciliopathies and Neurodevelopmental Delays. PMID:35456433
Multi-Omics Approach Points to the Importance of Oxylipins Metabolism in Early-Stage Breast Cancer. PMID:35454947
Prostanoid Signaling in Cancers: Expression and Regulation Patterns of Enzymes and Receptors. PMID:35453789
Immune-related biomarkers shared by inflammatory bowel disease and liver cancer. PMID:35452485
Integrative analysis of mutated genes and mutational processes reveals novel mutational biomarkers in colorectal cancer. PMID:35439935
Identification of potential pathogenic genes for severe aplastic anemia by whole-exome sequencing. PMID:35435273
Transcriptome Analysis in Hippocampus of Rats Prenatally Exposed to Valproic Acid and Effects of Intranasal Treatment of Oxytocin. PMID:35432011
Potential therapeutic targets and molecular details of anthocyan-treated inflammatory bowel disease: a systematic bioinformatics analysis of network pharmacology. PMID:35423341
Machine learning methods applied to genotyping data capture interactions between single nucleotide variants in late onset Alzheimer's disease. PMID:35415203
Combining biomedical knowledge graphs and text to improve predictions for drug-target interactions and drug-indications. PMID:35402106
Exploration of the Specific Pathology of HXMM Tablet Against Retinal Injury Based on Drug Attack Model to Network Robustness. PMID:35401181
Mechanism of Pilose Antler in Treatment of Osteoporosis Based on Network Pharmacology. PMID:35399830
Single-Cell Transcriptome Analysis Reveals the Role of Pancreatic Secretome in COVID-19 Associated Multi-organ Dysfunctions. PMID:35394619
Identification of Novel Biomarkers With Diagnostic Value and Immune Infiltration in Burn Injury. PMID:35391790
Network-based stage-specific drug repurposing for Alzheimer's disease. PMID:35386099
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. PMID:35379995
Da-Chai-Hu-Tang Protects From Acute Intrahepatic Cholestasis by Inhibiting Hepatic Inflammation and Bile Accumulation via Activation of PPARα. PMID:35370715
Seungmagalgeun-Tang, a Traditional Herbal Formula, Alleviates Skin Inflammation and Depression-Like Behavior in Atopic Dermatitis Mice under Sleep Deprivation Conditions. PMID:35368752
The potential mechanism of Bupleurum against anxiety was predicted by network pharmacology study and molecular docking. PMID:35366129
Unveiling Potential Mechanisms of Spatholobi Caulis against Lung Metastasis of Malignant Tumor by Network Pharmacology and Molecular Docking. PMID:35356244
Application of Transcriptomics for Predicting Protein Interaction Networks, Drug Targets and Drug Candidates. PMID:35356062
Identification of hub genes for adult patients with sepsis via RNA sequencing. PMID:35332254
Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes. PMID:35321029
Network Pharmacology and Molecular Docking Elucidate the Pharmacological Mechanism of the OSTEOWONDER Capsule for Treating Osteoporosis. PMID:35295951
Protecting effect of emodin in experimental autoimmune encephalomyelitis mice by inhibiting microglia activation and inflammation via Myd88/PI3K/Akt/NF-κB signalling pathway. PMID:35287559
Revealing Calcium Signaling Pathway as Novel Mechanism of Danhong Injection for Treating Acute Myocardial Infarction by Systems Pharmacology and Experiment Validation. PMID:35281886
Distinct Epileptogenic Mechanisms Associated with Seizures in Wolf-Hirschhorn Syndrome. PMID:35278209
SAAED: Embedding and Deep Learning Enhance Accurate Prediction of Association Between circRNA and Disease. PMID:35273640
An in silico and in vitro integrated analysis method to reveal the curative mechanisms and pharmacodynamic substances of Bufei granule on chronic obstructive pulmonary disease. PMID:35266101
Pan-human consensus genome significantly improves the accuracy of RNA-seq analyses. PMID:35256454
Immune Cells Profiles in the Different Sites of COVID-19-Affected Lung Lobes in a Single Patient. PMID:35252273
Deciphering Cell-Type-Specific Gene Expression Signatures of Cardiac Diseases Through Reconstruction of Bulk Transcriptomes. PMID:35252172
Host-microbiome protein-protein interactions capture disease-relevant pathways. PMID:35246229
An Integrated Pharmacology-Based Strategy to Investigate the Potential Mechanism of Xiebai San in Treating Pediatric Pneumonia. PMID:35237157
DeepWalk based method to predict lncRNA-miRNA associations via lncRNA-miRNA-disease-protein-drug graph. PMID:35216549
Interferon-β Activity Is Affected by S100B Protein. PMID:35216109
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis. PMID:35210568
African Genomic Medicine Portal: A Web Portal for Biomedical Applications. PMID:35207753
Unlocking the Memory Component of Alzheimer's Disease: Biological Processes and Pathways across Brain Regions. PMID:35204764
Identification of Potential Targets Linked to the Cardiovascular/Alzheimer's Axis through Bioinformatics Approaches. PMID:35203598
Deep neural network prediction of genome-wide transcriptome signatures - beyond the Black-box. PMID:35197482
Pseudoautosomal Region 1 Overdosage Affects the Global Transcriptome in iPSCs From Patients With Klinefelter Syndrome and High-Grade X Chromosome Aneuploidies. PMID:35186953
TRmir: A Comprehensive Resource for Human Transcriptional Regulatory Information of MiRNAs. PMID:35186035
Mechanisms of magnoliae cortex on treating sarcopenia explored by GEO gene sequencing data combined with network pharmacology and molecular docking. PMID:35176999
Deciphering the involvement of iron targets in colorectal cancer: a network biology approach. PMID:35173863
Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis. PMID:35173416
Human Immune System Diseasome Networks and Female Oviductal Microenvironment: New Horizons to be Discovered. PMID:35154249
Network Pharmacology and Molecular Docking-Based Mechanism Study to Reveal the Protective Effect of Salvianolic Acid C in a Rat Model of Ischemic Stroke. PMID:35153756
An Integrative Network Approach to Identify Common Genes for the Therapeutics in Tuberculosis and Its Overlapping Non-Communicable Diseases. PMID:35153741
Identifying patients and assessing variant pathogenicity for an autosomal dominant disease-driving gene. PMID:35146449
Network Pharmacology and Molecular Docking Analysis on Pharmacological Mechanisms of Astragalus membranaceus in the Treatment of Gastric Ulcer. PMID:35140802
Kaempferol and Apigenin suppresses the stemness properties of TNBC cells by modulating Sirtuins. PMID:35129762
Identification of circular RNAs and functional competing endogenous RNA networks in human proximal tubular epithelial cells treated with sodium-glucose cotransporter 2 inhibitor dapagliflozin in diabetic kidney disease. PMID:35129424
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines. PMID:35115730
Network pharmacology and in vitro studies reveal the pharmacological effects and molecular mechanisms of Shenzhi Jiannao prescription against vascular dementia. PMID:35109845
Detecting gene-gene interactions from GWAS using diffusion kernel principal components. PMID:35105309
Signatures of malignant cells and novel therapeutic targets revealed by single-cell sequencing in lung adenocarcinoma. PMID:35102706
Investigation of molecular regulation mechanism under the pathophysiology of subarachnoid hemorrhage. PMID:35087950
Elucidation of Potential Targets of San-Miao-San in the Treatment of Osteoarthritis Based on Network Pharmacology and Molecular Docking Analysis. PMID:35087596
Dynamic Functional Connectivity Alterations and Their Associated Gene Expression Pattern in Autism Spectrum Disorders. PMID:35082596
Modular characteristics and the mechanism of Chinese medicine's treatment of gastric cancer: a data mining and pharmacology-based identification. PMID:35071471
Prediction of the Mechanisms by Which Quercetin Enhances Cisplatin Action in Cervical Cancer: A Network Pharmacology Study and Experimental Validation. PMID:35070983
Erythropoietin Interacts with Specific S100 Proteins. PMID:35053268
Dicer dependent tRNA derived small RNAs promote nascent RNA silencing. PMID:35048990
Multi-scale mechanism of antiviral drug-alike phytoligands from Ayurveda in managing COVID-19 and associated metabolic comorbidities: insights from network pharmacology. PMID:34993740
Network pharmacology reveals the potential mechanism of Baiying Qinghou decoction in treating laryngeal squamous cell carcinoma. PMID:34986125
An effective drug-disease associations prediction model based on graphic representation learning over multi-biomolecular network. PMID:34983364
gGATLDA: lncRNA-disease association prediction based on graph-level graph attention network. PMID:34983363
Network Pharmacology Study on Molecular Mechanisms of Zhishi Xiebai Guizhi Decoction in the Treatment of Coronary Heart Disease. PMID:34966435
Impact of Qi-Invigorating Traditional Chinese Medicines on Diffuse Large B Cell Lymphoma Based on Network Pharmacology and Experimental Validation. PMID:34955857
Genome-Wide Analysis of DNA Methylation in Buccal Cells of Children Conceived through IVF and ICSI. PMID:34946866
In Silico Investigation of the Biological Implications of Complex DNA Damage with Emphasis in Cancer Radiotherapy through a Systems Biology Approach. PMID:34946681
A System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach. PMID:34944525
Predictive Biomarkers for Postmyocardial Infarction Heart Failure Using Machine Learning: A Secondary Analysis of a Cohort Study. PMID:34938340
Detecting Critical Functional Ingredients Group and Mechanism of Xuebijing Injection in Treating Sepsis. PMID:34938184
Identification of Potential Genetic Biomarkers and Target Genes of Peri-Implantitis Using Bioinformatics Tools. PMID:34931168
Transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter. PMID:34931033
Network Integration Analysis and Immune Infiltration Analysis Reveal Potential Biomarkers for Primary Open-Angle Glaucoma. PMID:34926471
Use of a Network-Based Method to Identify Latent Genes Associated with Hearing Loss in Children. PMID:34912812
Competitive endogenous RNA network and pathway-based analysis of LncRNA single-nucleotide polymorphism in myasthenia gravis. PMID:34907261
Shared Molecular Mechanisms between Atherosclerosis and Periodontitis by Analyzing the Transcriptomic Alterations of Peripheral Blood Monocytes. PMID:34899963
Graph Embedding Based Novel Gene Discovery Associated With Diabetes Mellitus. PMID:34899863
Computational Network Pharmacology-Based Strategy to Capture Key Functional Components and Decode the Mechanism of Chai-Hu-Shu-Gan-San in Treating Depression. PMID:34867413
Uncovering Bupi Yishen Formula Pharmacological Mechanisms Against Chronic Kidney Disease by Network Pharmacology and Experimental Validation. PMID:34867380
Potential Mechanism of Dingji Fumai Decoction Against Atrial Fibrillation Based on Network Pharmacology, Molecular Docking, and Experimental Verification Integration Strategy. PMID:34859062
Identification of the Active Constituents and Significant Pathways of Shen-qi-Yi-zhu Decoction on Antigastric Cancer: A Network Pharmacology Research and Experimental Validation. PMID:34853601
TissueNexus: a database of human tissue functional gene networks built with a large compendium of curated RNA-seq data. PMID:34850130
Disentangling genetic feature selection and aggregation in transcriptome-wide association studies. PMID:34849857
MOSES: A New Approach to Integrate Interactome Topology and Functional Features for Disease Gene Prediction. PMID:34828319
Pharmacological Mechanism of Danggui-Sini Formula for Intervertebral Disc Degeneration: A Network Pharmacology Study. PMID:34805401
α-Synuclein antisense transcript SNCA-AS1 regulates synapses- and aging-related genes suggesting its implication in Parkinson's disease. PMID:34799977
HFIP: an integrated multi-omics data and knowledge platform for the precision medicine of heart failure. PMID:34791105
Bioinformatics approach to identify common gene signatures of patients with coronavirus 2019 and lung adenocarcinoma. PMID:34775559
ImmReg: the regulon atlas of immune-related pathways across cancer types. PMID:34755873
FusionGDB 2.0: fusion gene annotation updates aided by deep learning. PMID:34755868
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients. PMID:34746695
Network Biology Approaches to Achieve Precision Medicine in Inflammatory Bowel Disease. PMID:34745229
Comparative Host-Pathogen Interaction Analyses of SARS-CoV2 and Aspergillus fumigatus, and Pathogenesis of COVID-19-Associated Aspergillosis. PMID:34738157
Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis. PMID:34715778
A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease. PMID:34712920
Dissecting the Pathogenesis of Diabetic Retinopathy Based on the Biological ceRNA Network and Genome Variation Disturbance. PMID:34707685
Exploring biological basis of Syndrome differentiation in coronary heart disease patients with two distinct Syndromes by integrated multi-omics and network pharmacology strategy. PMID:34702323
Machine learning applications for therapeutic tasks with genomics data. PMID:34693370
TPSC: a module detection method based on topology potential and spectral clustering in weighted networks and its application in gene co-expression module discovery. PMID:34689740
Genomic Risk Factors for Cervical Cancer. PMID:34680286
Text Mining for Building Biomedical Networks Using Cancer as a Case Study. PMID:34680062
Investigation of the Active Ingredients and Mechanism of Hudi Enteric-Coated Capsules in DSS-Induced Ulcerative Colitis Mice Based on Network Pharmacology and Experimental Verification. PMID:34675488
Investigation on the mechanisms of guiqi huoxue capsule for treating cervical spondylosis based on network pharmacology and molecular docking. PMID:34664825
Time-ordered dysregulated ceRNA networks reveal disease progression and diagnostic biomarkers in ischemic and dilated cardiomyopathy. PMID:34657123
Deep post-GWAS analysis identifies potential risk genes and risk variants for Alzheimer's disease, providing new insights into its disease mechanisms. PMID:34654853
Investigation of anti-osteoporosis mechanisms of Rehmanniae Radix Preparata based on network pharmacology and experimental verification. PMID:34649566
WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway. PMID:34646130
TIGER: The gene expression regulatory variation landscape of human pancreatic islets. PMID:34644572
Exploring the Potential Mechanism of Shennao Fuyuan Tang for Ischemic Stroke Based on Network Pharmacology and Molecular Docking. PMID:34603472
Differentially expressed genes in Alzheimer's disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1. PMID:34589742
Utilizing Network Pharmacology to Explore the Possible Mechanism of Coptidis Rhizoma in Kawasaki Disease. PMID:34589453
Mechanism exploration of Gouqi-wentang formula against type 2 diabetes mellitus by phytochemistry and network pharmacology-based analysis and biological validation. PMID:34579756
Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome. PMID:34570756
Transcriptional and cellular signatures of cortical morphometric remodelling in chronic pain. PMID:34561394
Citrate Synthase and OGDH as Potential Biomarkers of Atherosclerosis under Chronic Stress. PMID:34539976
Characterization of the Potential Role of NTPCR in Epithelial Ovarian Cancer by Integrating Transcriptomic and Metabolomic Analysis. PMID:34539736
Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing. PMID:34535131
Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes. PMID:34526518
Identification of Common Driver Gene Modules and Associations between Cancers through Integrated Network Analysis. PMID:34504716
Network pharmacology-based analysis in determining the mechanisms of Huoxin pill in protecting against myocardial infarction. PMID:34493157
Positive selection of skeleton-related genes during duck domestication revealed by whole genome sequencing. PMID:34488647
An Ovarian Cancer Susceptible Gene Prediction Method Based on Deep Learning Methods. PMID:34485310
TMEA, a Polyphenol in Sanguisorba officinalis, Promotes Thrombocytopoiesis by Upregulating PI3K/Akt Signaling. PMID:34485295
Exploring the Biological Mechanism of Huang Yam in Treating Tumors and Preventing Antitumor Drug-Induced Cardiotoxicity Using Network Pharmacology and Molecular Docking Technology. PMID:34484411
Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis. PMID:34480296
Uncovering the Mechanisms and Molecular Targets of Weibing Formula 1 against Gastritis: Coupling Network Pharmacology with GEO Database. PMID:34471638
Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder. PMID:34471112
Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review. PMID:34447243
Drug Discovery of Spinal Muscular Atrophy (SMA) from the Computational Perspective: A Comprehensive Review. PMID:34445667
Whole-Genome Differentially Hydroxymethylated DNA Regions among Twins Discordant for Cardiovascular Death. PMID:34440357
Network pharmacology-based prediction of the active compounds and mechanism of Buyang Huanwu Decoction for ischemic stroke. PMID:34434264
A global map of associations between types of protein posttranslational modifications and human genetic diseases. PMID:34430807
Molecular Subtypes of Oral Squamous Cell Carcinoma Based on Immunosuppression Genes Using a Deep Learning Approach. PMID:34422810
A convergent molecular network underlying autism and congenital heart disease. PMID:34411509
Mechanism of Fei-Xian Formula in the Treatment of Pulmonary Fibrosis on the Basis of Network Pharmacology Analysis Combined with Molecular Docking Validation. PMID:34394391
Identification of COVID-19 and Dengue Host Factor Interaction Networks Based on Integrative Bioinformatics Analyses. PMID:34394108
Identify Inflammatory Bowel Disease-Related Genes Based on Machine Learning. PMID:34381790
Shiquan Yuzhen Decoction inhibits angiogenesis and tumor apoptosis caused by non-small cell lung cancer and promotes immune response. PMID:34377231
Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis. PMID:34357353
Identification of Novel Susceptible Genes of Gastric Cancer Based on Integrated Omics Data. PMID:34354996
Characterization of Five Transmembrane Proteins: With Focus on the Tweety, Sideroflexin, and YIP1 Domain Families. PMID:34350187
Anti-Autophagy Mechanism of Zhi Gan Prescription Based on Network Pharmacology in Nonalcoholic Steatohepatitis Rats. PMID:34349657
MicroRNA-216b targets HK2 to potentiate autophagy and apoptosis of breast cancer cells via the mTOR signaling pathway. PMID:34345220
TrendyGenes, a computational pipeline for the detection of literature trends in academia and drug discovery. PMID:34344904
Identifying molecular insight of synergistic complexities for SARS-CoV-2 infection with pre-existing type 2 diabetes. PMID:34340124
A Potential circRNA-miRNA-mRNA Regulatory Network in Asthmatic Airway Epithelial Cells Identified by Integrated Analysis of Microarray Datasets. PMID:34336929
Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats. PMID:34321866
Network Pharmacology-Based Mechanistic Investigation of Jinshui Huanxian Formula Acting on Idiopathic Pulmonary Fibrosis. PMID:34306156
Insights into the molecular mechanisms of Huangqi decoction on liver fibrosis via computational systems pharmacology approaches. PMID:34301291
A comprehensive investigation on liver regeneration: a meta-analysis and systems biology approach. PMID:34295986
DeepGP: An Integrated Deep Learning Method for Endocrine Disease Gene Prediction Using Omics Data. PMID:34295899
Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection. PMID:34276672
Detecting lncRNA-Cancer Associations by Combining miRNAs, Genes, and Prognosis With Matrix Factorization. PMID:34262591
The 2021 update of the EPA's adverse outcome pathway database. PMID:34253739
Identifying ceRNA Networks Associated With the Susceptibility and Persistence of Atrial Fibrillation Through Weighted Gene Co-Expression Network Analysis. PMID:34249084
Study on the Molecular Mechanism of the Herbal Couple Sparganii Rhizoma-Curcumae Rhizoma in the Treatment of Lung Cancer Based on Network Pharmacology. PMID:34239587
Towards a global investigation of transcriptomic signatures through co-expression networks and pathway knowledge for the identification of disease mechanisms. PMID:34197603
Summarizing the Effective Herbs for the Treatment of Hypertensive Nephropathy by Complex Network and Machine Learning. PMID:34194519
Whole-Exome Sequencing Analysis of Human Semen Quality in Russian Multiethnic Population. PMID:34178030
Advancing clinical genomics and precision medicine with GVViZ: FAIR bioinformatics platform for variable gene-disease annotation, visualization, and expression analysis. PMID:34174938
Study of the Active Components and Molecular Mechanism of Tripterygium wilfordii in the Treatment of Diabetic Nephropathy. PMID:34164430
Genome-enabled discovery of evolutionary divergence in brains and behavior. PMID:34155279
A network pharmacology approach to determine the underlying mechanisms of action of Yishen Tongluo formula for the treatment of oligoasthenozoospermia. PMID:34153045
A structural deep network embedding model for predicting associations between miRNA and disease based on molecular association network. PMID:34135401
A machine learning framework that integrates multi-omics data predicts cancer-related LncRNAs. PMID:34134612
Genome-wide discovery of hidden genes mediating known drug-disease association using KDDANet. PMID:34131148
DGLinker: flexible knowledge-graph prediction of disease-gene associations. PMID:34125897
A framework for automated gene selection in genomic applications. PMID:34113001
Integration of Immunome With Disease-Gene Network Reveals Common Cellular Mechanisms Between IMIDs and Drug Repurposing Strategies. PMID:34108969
Overexpression of DDIT4 and TPTEP1 are associated with metastasis and advanced stages in colorectal cancer patients: a study utilizing bioinformatics prediction and experimental validation. PMID:34107956
Cell Heterogeneity Analysis in Single-Cell RNA-seq Data Using Mixture Exponential Graph and Markov Random Field Model. PMID:34095314
Differentially Expressed Genes and Enriched Signaling Pathways in the Adipose Tissue of Obese People. PMID:34093637
GCSENet: A GCN, CNN and SENet ensemble model for microRNA-disease association prediction. PMID:34081706
miRNAs and Genes Involved in the Interplay between Ocular Hypertension and Primary Open-Angle Glaucoma. Oxidative Stress, Inflammation, and Apoptosis Networks. PMID:34063878
A multiple network-based bioinformatics pipeline for the study of molecular mechanisms in oncological diseases for personalized medicine. PMID:34050359
Kuanxiong Aerosol () in Treatment of Angina Pectoris: A Literature Review and Network Pharmacology. PMID:34047948
Rare protein-coding variants implicate genes involved in risk of suicide death. PMID:34042246
An Integrated Analysis of Network Pharmacology, Molecular Docking, and Experiment Validation to Explore the New Candidate Active Component and Mechanism of Cuscutae Semen-Mori Fructus Coupled-Herbs in Treating Oligoasthenozoospermia. PMID:34040346
Identification of key genes in calcific aortic valve disease via weighted gene co-expression network analysis. PMID:34020624
Utilizing graph machine learning within drug discovery and development. PMID:34013350
An overview of graph databases and their applications in the biomedical domain. PMID:34003247
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. PMID:33972514
Network Pharmacology-Based Prediction of Mechanism of Shenzhuo Formula for Application to DKD. PMID:33968154
Network pharmacology integrated with experimental validation revealed the anti-inflammatory effects of Andrographis paniculata. PMID:33963245
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. PMID:33961781
Prediction of Single-Nucleotide Polymorphisms within microRNAs Binding Sites of Neuronal Genes Related to Multiple Sclerosis: A Preliminary Study. PMID:33959565
Knowledge-Based Biomedical Data Science. PMID:33954284
A resource to explore the discovery of rare diseases and their causative genes. PMID:33947870
A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression. PMID:33937393
Investigating the Biomarkers of the Sasang Constitution via Network Pharmacology Approach. PMID:33936241
The effect of cell isolation methods on the human transcriptome profiling and microbial transcripts of peripheral blood. PMID:33929647
MicroRNAs in the aqueous humor of patients with different types of glaucoma. PMID:33929592
The Underlying Molecular Mechanisms Involved in Traditional Chinese Medicine Smilax china L. for the Treatment of Pelvic Inflammatory Disease. PMID:33927774
Shared Neurodevelopmental Perturbations Can Lead to Intellectual Disability in Individuals with Distinct Rare Chromosome Duplications. PMID:33922640
Study on the Sleep-Improvement Effects of Hemerocallis citrina Baroni in Drosophila melanogaster and Targeted Screening to Identify Its Active Components and Mechanism. PMID:33920660
Obstructive Sleep Apnea and Dementia-Common Gene Associations through Network-Based Identification of Common Driver Genes. PMID:33918603
VB10, a new blood biomarker for differential diagnosis and recovery monitoring of acute viral and bacterial infections. PMID:33906069
A New Framework for Discovering Protein Complex and Disease Association via Mining Multiple Databases. PMID:33905111
The VRNetzer platform enables interactive network analysis in Virtual Reality. PMID:33893283
Network-Based Analysis of Fatal Comorbidities of COVID-19 and Potential Therapeutics. PMID:33891554
The screening of immune-related biomarkers for prognosis of lung adenocarcinoma. PMID:33870858
Shared Molecular Mechanisms between Alzheimer's Disease and Periodontitis Revealed by Transcriptomic Analysis. PMID:33869630
H3ABioNet genomic medicine and microbiome data portals hackathon proceedings. PMID:33864455
Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease patients. PMID:33847347
Discovering key transcriptomic regulators in pancreatic ductal adenocarcinoma using Dirichlet process Gaussian mixture model. PMID:33846515
Artificial intelligence to deep learning: machine intelligence approach for drug discovery. PMID:33844136
Mining the Selective Remodeling of DNA Methylation in Promoter Regions to Identify Robust Gene-Level Associations With Phenotype. PMID:33842534
Exploring the Imbalance of Periodontitis Immune System From the Cellular to Molecular Level. PMID:33841510
MendelVar: gene prioritization at GWAS loci using phenotypic enrichment of Mendelian disease genes. PMID:33836063
Chlorogenic Acid Inhibits Human Glioma U373 Cell Progression via Regulating the SRC/MAPKs Signal Pathway: Based on Network Pharmacology Analysis. PMID:33833498
A study of transposable element-associated structural variations (TASVs) using a de novo-assembled Korean genome. PMID:33833373
MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation. PMID:33826889
Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase. PMID:33824320
Outside-in induction of the IFITM3 trafficking system by infections, including SARS-CoV-2, in the pathobiology of Alzheimer's disease. PMID:33817671
Network bioinformatics analysis provides insight into drug repurposing for COVID-19. PMID:33817623
Network Pharmacology Analysis of Traditional Chinese Medicine Formula Shuang Di Shou Zhen Tablets Treating Nonexudative Age-Related Macular Degeneration. PMID:33815556
A Systematic Review of Genomic Regions and Candidate Genes Underlying Behavioral Traits in Farmed Mammals and Their Link with Human Disorders. PMID:33800722
Cingulate networks associated with gray matter loss in Parkinson's disease show high expression of cholinergic genes in the healthy brain. PMID:33792979
Powerful p-value combination methods to detect incomplete association. PMID:33772054
Silencing of miR-20b-5p Exerts Inhibitory Effect on Diabetic Retinopathy via Inactivation of THBS1 Gene Induced VEGF/Akt/PI3K Pathway. PMID:33758526
Cardiovascular informatics: building a bridge to data harmony. PMID:33751044
A Network Pharmacology-Based Approach to Investigating the Mechanisms of Fushen Granule Effects on Intestinal Barrier Injury in Chronic Renal Failure. PMID:33747100
Systematic elucidation of the mechanism of Jingyin granule in the treatment of Novel Coronavirus (COVID-19) Pneumonia via Network Pharmacology. PMID:33746581
A representation learning model based on variational inference and graph autoencoder for predicting lncRNA-disease associations. PMID:33745450
Identification of disease treatment mechanisms through the multiscale interactome. PMID:33741907
Search and visualization of gene-drug-disease interactions for pharmacogenomics and precision medicine research using GeneDive. PMID:33737208
Boosting GWAS using biological networks: A study on susceptibility to familial breast cancer. PMID:33735170
Synergistic Network Pharmacology for Traditional Chinese Medicine Liangxue Tongyu Formula in Acute Intracerebral Hemorrhagic Stroke. PMID:33727915
Insights into the pathogenesis of psoriatic arthritis from genetic studies. PMID:33712923
Short loop functional commonality identified in leukaemia proteome highlights crucial protein sub-networks. PMID:33709075
An Update on MRMAssayDB: A Comprehensive Resource for Targeted Proteomics Assays in the Community. PMID:33683131
Computational Analysis Indicates That PARP1 Acts as a Histone Deacetylases Interactor Sharing Common Lysine Residues for Acetylation, Ubiquitination, and SUMOylation in Alzheimer's and Parkinson's Disease. PMID:33681613
Genomic and Transcriptomic Analyses Reveals ZNF124 as a Critical Regulator in Highly Aggressive Medulloblastomas. PMID:33681213
The DBSAV Database: Predicting Deleteriousness of Single Amino Acid Variations in the Human Proteome. PMID:33676930
A chromosome-level genome of Astyanax mexicanus surface fish for comparing population-specific genetic differences contributing to trait evolution. PMID:33664263
Molecular characterization of the stress network in individuals at risk for schizophrenia. PMID:33644266
Retroviral integrations contribute to elevated host cancer rates during germline invasion. PMID:33637755
Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy. PMID:33628839
Uncovering the Anti-Lung-Cancer Mechanisms of the Herbal Drug FDY2004 by Network Pharmacology. PMID:33628308
A Network Pharmacology Study on the Molecular Mechanisms of FDY003 for Breast Cancer Treatment. PMID:33628298
The tumor therapy landscape of synthetic lethality. PMID:33627666
Multimodal single-cell/nucleus RNA sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease. PMID:33627474
Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease. PMID:33599610
Systems biology analysis identifies TNFRSF9 as a functional marker of tumor-infiltrating regulatory T-cell enabling clinical outcome prediction in lung cancer. PMID:33598101
Showing NAFLD, as a key connector disease between Alzheimer's disease and diabetes via analysis of systems biology. PMID:33585009
Identification of Functional lncRNAs Associated With Ovarian Endometriosis Based on a ceRNA Network. PMID:33584822
Global variability analysis of mRNA and protein concentrations across and within human tissues. PMID:33575562
A Network Pharmacology Approach to Estimate Potential Targets of the Active Ingredients of Epimedium for Alleviating Mild Cognitive Impairment and Treating Alzheimer's Disease. PMID:33574879
System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of GanDouLing for Wilson's Disease. PMID:33564316
A Systems Biology Approach for Hypothesizing the Effect of Genetic Variants on Neuroimaging Features in Alzheimer's Disease. PMID:33554913
Host Transcriptomic Response Following Administration of Rotavirus Vaccine in Infants' Mimics Wild Type Infection. PMID:33552046
From fuzziness to precision medicine: on the rapidly evolving proteomics with implications in mitochondrial connectivity to rare human disease. PMID:33521598
Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology. PMID:33517789
Evolutionary conservation and divergence of the human brain transcriptome. PMID:33514394
Potential effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification. PMID:33513419
Exploring the mechanism of aidi injection for lung cancer by network pharmacology approach and molecular docking validation. PMID:33506873
Germline copy number variations in BRCA1/2 negative families: Role in the molecular etiology of hereditary breast cancer in Tunisia. PMID:33503040
Network pharmacology integrated molecular docking reveals the bioactive components and potential targets of Morinda officinalis-Lycium barbarum coupled-herbs against oligoasthenozoospermia. PMID:33500463
Breast Cancer-Derived Microvesicles Are the Source of Functional Metabolic Enzymes as Potential Targets for Cancer Therapy. PMID:33499132
Intestinal mRNA expression profile and bioinformatics analysis in a methamphetamine-induced mouse model of inflammatory bowel disease. PMID:33490181
Gene co-expression in the interactome: moving from correlation toward causation via an integrated approach to disease module discovery. PMID:33479222
An empirical meta-analysis of the life sciences linked open data on the web. PMID:33479214
Network Pharmacology Approach to Explore the Potential Mechanisms of Jieduan-Niwan Formula Treating Acute-on-Chronic Liver Failure. PMID:33456481
Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study. PMID:33444408
Internetwork connectivity of molecular networks across species of life. PMID:33441907
Artificial Intelligence in Drug Discovery: A Comprehensive Review of Data-driven and Machine Learning Approaches. PMID:33437151
An ensemble learning approach for modeling the systems biology of drug-induced injury. PMID:33435983
DF-MDA: An effective diffusion-based computational model for predicting miRNA-disease association. PMID:33429082
Prediction of lncRNA-disease associations via an embedding learning HOPE in heterogeneous information networks. PMID:33425486
Transcriptomic landscaping of core genes and pathways of mild and severe psoriasis vulgaris. PMID:33416099
Uncovering the mechanism of Ge-Gen-Qin-Lian decoction for treating ulcerative colitis based on network pharmacology and molecular docking verification. PMID:33409535
Antidiarrheal Effect of Sechang-Zhixie-San on Acute Diarrhea Mice and Network Pharmacology Deciphering Its Characteristics and Potential Mechanisms. PMID:33381214
The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson's Disease Based on a Network Pharmacology Approach. PMID:33381034
Application of Biological Domain Knowledge Based Feature Selection on Gene Expression Data. PMID:33374969
In silico ranking of phenolics for therapeutic effectiveness on cancer stem cells. PMID:33371879
An Investigation of the Molecular Mechanisms Underlying the Analgesic Effect of Jakyak-Gamcho Decoction: A Network Pharmacology Study. PMID:33343676
Identification of Novel Potential Genes Involved in Cancer by Integrated Comparative Analyses. PMID:33334055
Interferon Beta Activity Is Modulated via Binding of Specific S100 Proteins. PMID:33322098
Whole-genome sequencing analysis of Y chromosome microdeletion: a case report. PMID:33317362
A Comparison of Gene Expression Changes in the Blood of Individuals Consuming Diets Supplemented with Olives, Nuts or Long-Chain Omega-3 Fatty Acids. PMID:33302351
A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients. PMID:33293514
Network and Evolutionary Analysis of Human Epigenetic Regulators to Unravel Disease Associations. PMID:33291839
Text mining approaches for dealing with the rapidly expanding literature on COVID-19. PMID:33279995
An Automated Functional Annotation Pipeline That Rapidly Prioritizes Clinically Relevant Genes for Autism Spectrum Disorder. PMID:33261099
What Can Machine Learning Approaches in Genomics Tell Us about the Molecular Basis of Amyotrophic Lateral Sclerosis? PMID:33256133
CD74, a novel predictor for bronchopulmonary dysplasia in preterm infants. PMID:33235138
The IMEx coronavirus interactome: an evolving map of Coronaviridae-host molecular interactions. PMID:33206959
Mechanisms of Core Chinese Herbs against Colorectal Cancer: A Study Based on Data Mining and Network Pharmacology. PMID:33193800
Virtual screening and network pharmacology-based synergistic mechanism identification of multiple components contained in Guanxin V against coronary artery disease. PMID:33187508
Comprehensive mapping of the human cytokine gene regulatory network. PMID:33179750
Revealing the Pharmacological Mechanism of Acorus tatarinowii in the Treatment of Ischemic Stroke Based on Network Pharmacology. PMID:33178313
Integrated analysis of transcriptomic and metabolomic data demonstrates the significant role of pyruvate carboxylase in the progression of ovarian cancer. PMID:33177242
Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID-19. PMID:33140889
A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease. PMID:33138777
The Model of PPARγ-Downregulated Signaling in Psoriasis. PMID:33133175
Systems pharmacology approach uncovers Ligustilide attenuates experimental colitis in mice by inhibiting PPARγ-mediated inflammation pathways. PMID:33130971
A Novel Network Pharmacology Strategy to Decode Mechanism of Lang Chuang Wan in Treating Systemic Lupus Erythematosus. PMID:33117150
High-depth African genomes inform human migration and health. PMID:33116287
Insights into the mechanism of Arnebia euchroma on leukemia via network pharmacology approach. PMID:33109189
Preclinical validation of therapeutic targets predicted by tensor factorization on heterogeneous graphs. PMID:33106501
Systems Level Analysis and Identification of Pathways and Key Genes Associated with Delirium. PMID:33086708
Finding disease modules for cancer and COVID-19 in gene co-expression networks with the Core&Peel method. PMID:33077837
A novel estimator of the interaction matrix in Graphical Gaussian Model of omics data using the entropy of non-equilibrium systems. PMID:33067612
Toward Preparing a Knowledge Base to Explore Potential Drugs and Biomedical Entities Related to COVID-19: Automated Computational Approach. PMID:33055059
Mitochondria under the spotlight: On the implications of mitochondrial dysfunction and its connectivity to neuropsychiatric disorders. PMID:33033576
Single-Cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning. PMID:33021809
Phenotypically Similar Rare Disease Identification from an Integrative Knowledge Graph for Data Harmonization: Preliminary Study. PMID:33006565
iMDA-BN: Identification of miRNA-disease associations based on the biological network and graph embedding algorithm. PMID:33005302
Chronic stepwise cerebral hypoperfusion differentially induces synaptic proteome changes in the frontal cortex, occipital cortex, and hippocampus in rats. PMID:32994510
MicroRNA-203 inhibits epithelial-mesenchymal transition, migration, and invasion of renal cell carcinoma cells via the inactivation of the PI3K/AKT signaling pathway by inhibiting CAV1. PMID:32990143
Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. PMID:32989326
An investigation into the molecular basis of cancer comorbidities in coronavirus infection. PMID:32970391
Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning. PMID:32967266
An optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome. PMID:32954517
Systems pharmacology-based approach to investigate the mechanisms of Danggui-Shaoyao-san prescription for treatment of Alzheimer's disease. PMID:32948180
A network pharmacology study on analgesic mechanism of Yuanhu-Baizhi herb pair. PMID:32948176
Mechanisms of indigo naturalis on treating ulcerative colitis explored by GEO gene chips combined with network pharmacology and molecular docking. PMID:32938944
ANDDigest: a new web-based module of ANDSystem for the search of knowledge in the scientific literature. PMID:32921303
NEMPD: a network embedding-based method for predicting miRNA-disease associations by preserving behavior and attribute information. PMID:32912137
A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation. PMID:32911434
Prediction of drug-target interactions from multi-molecular network based on LINE network representation method. PMID:32894154
Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs. PMID:32879140
Genome-wide pathogenesis interpretation using a heat diffusion-based systems genetics method and implications for gene function annotation. PMID:32869547
Identification of Potential Interacting Proteins With the Extracellular Loops of the Neuronal Glycoprotein M6a by TMT/MS. PMID:32848694
A Pipeline for Integrated Theory and Data-Driven Modeling of Biomedical Data. PMID:32841121
Sex differences in circulating proteins in heart failure with preserved ejection fraction. PMID:32831121
Solid-phase inclusion as a mechanism for regulating unfolded proteins in the mitochondrial matrix. PMID:32821848
Identifying disease trajectories with predicate information from a knowledge graph. PMID:32819419
Network pharmacology suggests biochemical rationale for treating COVID-19 symptoms with a Traditional Chinese Medicine. PMID:32811894
The proteomic analysis of breast cell line exosomes reveals disease patterns and potential biomarkers. PMID:32782317
Exploring protective effect of Glycine tabacina aqueous extract against nephrotic syndrome by network pharmacology and experimental verification. PMID:32765640
MIPDH: A Novel Computational Model for Predicting microRNA-mRNA Interactions by DeepWalk on a Heterogeneous Network. PMID:32715187
A Network Pharmacology Approach to Investigate the Active Compounds and Mechanisms of Musk for Ischemic Stroke. PMID:32714405
Monoamine and genome-wide DNA methylation investigation in behavioral addiction. PMID:32678220
Small-Medium Extracellular Vesicles and Their miRNA Cargo in Retinal Health and Degeneration: Mediators of Homeostasis, and Vehicles for Targeted Gene Therapy. PMID:32670023
Toward heterogeneous information fusion: bipartite graph convolutional networks for in silico drug repurposing. PMID:32657387
A bioinformatics investigation into molecular mechanism of Yinzhihuang granules for treating hepatitis B by network pharmacology and molecular docking verification. PMID:32651427
New Analysis Framework Incorporating Mixed Mutual Information and Scalable Bayesian Networks for Multimodal High Dimensional Genomic and Epigenomic Cancer Data. PMID:32625238
A Comprehensive Network Pharmacology-Based Strategy to Investigate Multiple Mechanisms of HeChan Tablet on Lung Cancer. PMID:32595734
The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions. PMID:32587962
Prediction of Drug-Target Interactions From Multi-Molecular Network Based on Deep Walk Embedding Model. PMID:32582646
Learning Representations to Predict Intermolecular Interactions on Large-Scale Heterogeneous Molecular Association Network. PMID:32580123
A Knowledge-Based Machine Learning Approach to Gene Prioritisation in Amyotrophic Lateral Sclerosis. PMID:32575372
pyMeSHSim: an integrative python package for biomedical named entity recognition, normalization, and comparison of MeSH terms. PMID:32552728
Bioentity2vec: Attribute- and behavior-driven representation for predicting multi-type relationships between bioentities. PMID:32533701
A hybrid deep clustering approach for robust cell type profiling using single-cell RNA-seq data. PMID:32532794
Human gene and disease associations for clinical-genomics and precision medicine research. PMID:32508008
Interpreting molecular similarity between patients as a determinant of disease comorbidity relationships. PMID:32504002
SIRT1 accelerates the progression of activity-based anorexia. PMID:32499508
Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. PMID:32492425
A bibliometric analysis and visualization of medical data mining research. PMID:32481411
Analysis of GWAS-Derived Schizophrenia Genes for Links to Ischemia-Hypoxia Response of the Brain. PMID:32477182
Resveratrol: Multi-Targets Mechanism on Neurodegenerative Diseases Based on Network Pharmacology. PMID:32477148
Anti-Alzheimer's Disease Molecular Mechanism of Acori Tatarinowii Rhizoma Based on Network Pharmacology. PMID:32475979
Predicting miRNA-based disease-disease relationships through network diffusion on multi-omics biological data. PMID:32457435
Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds. PMID:32451392
Uncovering the active compounds and effective mechanisms of the dried mature sarcocarp of Cornus officinalis Sieb. Et Zucc. For the treatment of Alzheimer's disease through a network pharmacology approach. PMID:32450873
Revealing the Common Mechanisms of Scutellarin in Angina Pectoris and Ischemic Stroke Treatment via a Network Pharmacology Approach. PMID:32447519
High Expression of hsa_circRNA_001387 in Nasopharyngeal Carcinoma and the Effect on Efficacy of Radiotherapy. PMID:32440159
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker. PMID:32440005
Clinical Bioinformatics in Precise Diagnosis of Mitochondrial Disease. PMID:32439066
ThETA: transcriptome-driven efficacy estimates for gene-based TArget discovery. PMID:32437556
miRactDB characterizes miRNA-gene relation switch between normal and cancer tissues across pan-cancer. PMID:32436932
Si-Wei-Qing-Gan-Tang Improves Non-Alcoholic Steatohepatitis by Modulating the Nuclear Factor-κB Signal Pathway and Autophagy in Methionine and Choline Deficient Diet-Fed Rats. PMID:32425782
Determinants of transcription factor regulatory range. PMID:32424124
FGviewer: an online visualization tool for functional features of human fusion genes. PMID:32421816
Mutation severity spectrum of rare alleles in the human genome is predictive of disease type. PMID:32413045
Prioritizing Cancer Genes Based on an Improved Random Walk Method. PMID:32411180
Revealing new therapeutic opportunities through drug target prediction: a class imbalance-tolerant machine learning approach. PMID:32399556
Copy number variants and fixed duplications among 198 rhesus macaques (Macaca mulatta). PMID:32392208
Network Pharmacology-Based Exploration of Synergistic Mechanism of Guanxin II Formula (II) for Coronary Heart Disease. PMID:32388823
Predicting the Disease Genes of Multiple Sclerosis Based on Network Representation Learning. PMID:32373160
MACSNVdb: a high-quality SNV database for interspecies genetic divergence investigation among macaques. PMID:32367112
MicroRNA-100 Enhances Autophagy and Suppresses Migration and Invasion of Renal Cell Carcinoma Cells via Disruption of NOX4-Dependent mTOR Pathway. PMID:32356935
A network pharmacology-based study on Alzheimer disease prevention and treatment of Qiong Yu Gao. PMID:32351618
Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis. PMID:32346024
Uncovering the mechanism of the effects of Paeoniae Radix Alba on iron-deficiency anaemia through a network pharmacology-based strategy. PMID:32345291
Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons. PMID:32341540
Drug Research Meets Network Science: Where Are We? PMID:32338900
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. PMID:32325033
LMSM: A modular approach for identifying lncRNA related miRNA sponge modules in breast cancer. PMID:32324747
Systems Pharmacology Approach to Investigate the Mechanism of Kai-Xin-San in Alzheimer's Disease. PMID:32317964
PDZ Domains as Drug Targets. PMID:32313833
Predicting miRNA-disease association from heterogeneous information network with GraRep embedding model. PMID:32313121
Functional Interactomes of Genes Showing Association with Type-2 Diabetes and Its Intermediate Phenotypic Traits Point towards Adipo-Centric Mechanisms in Its Pathophysiology. PMID:32294959
Essential gene prediction in Drosophila melanogaster using machine learning approaches based on sequence and functional features. PMID:32257045
Unveiling new disease, pathway, and gene associations via multi-scale neural network. PMID:32251458
Centenarian Exomes as a Tool for Evaluating the Clinical Relevance of Germline Tumor Suppressor Mutations. PMID:32233832
Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria. PMID:32208162
Identification of Key Components in Colon Adenocarcinoma Using Transcriptome to Interactome Multilayer Framework. PMID:32193399
Prediction of Side Effects Using Comprehensive Similarity Measures. PMID:32190647
MicroRNAs association with azoospermia, oligospermia, asthenozoospermia, and teratozoospermia: a systematic review. PMID:32189180
Network Pharmacology Identifies the Mechanisms of Action of TaohongSiwu Decoction Against Essential Hypertension. PMID:32187175
AllEnricher: a comprehensive gene set function enrichment tool for both model and non-model species. PMID:32183716
Reveals of New Candidate Active Components in Hemerocallis Radix and Its Anti-Depression Action of Mechanism Based on Network Pharmacology Approach. PMID:32182911
Identification of FMR1-regulated molecular networks in human neurodevelopment. PMID:32179589
A learning based framework for diverse biomolecule relationship prediction in molecular association network. PMID:32170157
Diverse types of genomic evidence converge on alcohol use disorder risk genes. PMID:32170004
Transcriptomic Analyses for Identification and Prioritization of Genes Associated With Alzheimer's Disease in Humans. PMID:32154224
Edgetic perturbation signatures represent known and novel cancer biomarkers. PMID:32152446
The influence of rare variants in circulating metabolic biomarkers. PMID:32150548
In silico analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the human GJA3 gene associated with congenital cataract. PMID:32143568
Transcriptomic signatures of brain regional vulnerability to Parkinson's disease. PMID:32139796
Supervised learning is an accurate method for network-based gene classification. PMID:32129827
PHARMIP: An insilico method to predict genetics that underpin adverse drug reactions. PMID:32123669
Investigating the multi-target pharmacological mechanism of danhong injection acting on unstable angina by combined network pharmacology and molecular docking. PMID:32122353
ncRPheno: a comprehensive database platform for identification and validation of disease related noncoding RNAs. PMID:32122231
Evaluation of Pathway Activation for a Single Sample Toward Inflammatory Bowel Disease Classification. PMID:32117426
An Investigation of the Mechanism of Rapid Relief of Ulcerative Colitis Induced by Five-flavor Sophora Flavescens Enteric-coated Capsules Based on Network Pharmacology. PMID:32116186
DISNET: a framework for extracting phenotypic disease information from public sources. PMID:32110491
Network Pharmacology-Based Investigation of the System-Level Molecular Mechanisms of the Hematopoietic Activity of Samul-Tang, a Traditional Korean Herbal Formula. PMID:32104198
GenEpi: gene-based epistasis discovery using machine learning. PMID:32093643
Heterogeneous Multi-Layered Network Model for Omics Data Integration and Analysis. PMID:32063919
Exploration of databases and methods supporting drug repurposing: a comprehensive survey. PMID:32055842
Deriving disease modules from the compressed transcriptional space embedded in a deep autoencoder. PMID:32051402
Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain. PMID:32049002
Classification of Trispanins: A Diverse Group of Proteins That Function in Membrane Synthesis and Transport Mechanisms. PMID:32039202
Identifying Synergistic Mechanisms of Multiple Ingredients in Shuangbai Tablets against Proteinuria by Virtual Screening and a Network Pharmacology Approach. PMID:32025234
Study on the mechanisms of compound Kushen injection for the treatment of gastric cancer based on network pharmacology. PMID:32020871
An integrative analysis of genome-wide association study and regulatory SNP annotation datasets identified candidate genes for bipolar disorder. PMID:32009227
Consensus features nested cross-validation. PMID:31985777
Annotating and detecting phenotypic information for chronic obstructive pulmonary disease. PMID:31984360
Patient similarity by joint matrix trifactorization to identify subgroups in acute myeloid leukemia. PMID:31984320
Novel genes exhibiting DNA methylation alterations in Korean patients with chronic lymphocytic leukaemia: a methyl-CpG-binding domain sequencing study. PMID:31974418
Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis. PMID:31952466
miR-26b inhibits total neurite outgrowth, promotes cells apoptosis and downregulates neprilysin in Alzheimer's disease. PMID:31949715
Long non-coding RNA taurine-upregulated gene 1 promotes cells proliferation, migration and invasion while represses apoptosis, and upregulates AURKA expression in hepatocellular carcinoma. PMID:31949695
Domain-mediated interactions for protein subfamily identification. PMID:31937869
Combined network pharmacology and virtual reverse pharmacology approaches for identification of potential targets to treat vascular dementia. PMID:31937840
Uncovering the Pharmacological Mechanism of Stemazole in the Treatment of Neurodegenerative Diseases Based on a Network Pharmacology Approach. PMID:31936558
In silico analysis and high-risk pathogenic phenotype predictions of non-synonymous single nucleotide polymorphisms in human Crystallin beta A4 gene associated with congenital cataract. PMID:31935276
The promise and reality of therapeutic discovery from large cohorts. PMID:31929188
Integrative Construction and Analysis of Molecular Association Network in Human Cells by Fusing Node Attribute and Behavior Information. PMID:31923739
PLAG1 silencing promotes cell chemosensitivity in ovarian cancer via the IGF2 signaling pathway. PMID:31922228
Persistent Exposure to Fusobacterium nucleatum Triggers Chemokine/Cytokine Release and Inhibits the Proliferation and Osteogenic Differentiation Capabilities of Human Gingiva-Derived Mesenchymal Stem Cells. PMID:31921705
Mechanisms of tissue and cell-type specificity in heritable traits and diseases. PMID:31913361
Identification of biomarkers and drug repurposing candidates based on an immune-, inflammation- and membranous glomerulonephritis-associated triplets network for membranous glomerulonephritis. PMID:31910852
Utilizing network pharmacology to explore the underlying mechanism of Radix Salviae in diabetic retinopathy. PMID:31892939
KCTD15 is overexpressed in human childhood B-cell acute lymphoid leukemia. PMID:31882877
Identification of infectious disease-associated host genes using machine learning techniques. PMID:31881961
Identifying miRNA synergism using multiple-intervention causal inference. PMID:31881825
Heterogeneous network embedding enabling accurate disease association predictions. PMID:31865913
Benchmarking network algorithms for contextualizing genes of interest. PMID:31860671
GBDTCDA: Predicting circRNA-disease Associations Based on Gradient Boosting Decision Tree with Multiple Biological Data Fusion. PMID:31853227
The human DEPhOsphorylation Database DEPOD: 2019 update. PMID:31836896
Transcriptomic Characterization of the Human Insular Cortex and Claustrum. PMID:31827426
Working the literature harder: what can text mining and bibliometric analysis reveal? PMID:31822126
Sequence-Derived Markers of Drug Targets and Potentially Druggable Human Proteins. PMID:31803227
DeepMiR2GO: Inferring Functions of Human MicroRNAs Using a Deep Multi-Label Classification Model. PMID:31801264
Omics-based Investigation of Diet-induced Obesity Synergized with HBx, Src, and p53 Mutation Accelerating Hepatocarcinogenesis in Zebrafish Model. PMID:31795276
Construction and Analysis of Molecular Association Network by Combining Behavior Representation and Node Attributes. PMID:31788002
Reconstruction of Cell-type-Specific Interactomes at Single-Cell Resolution. PMID:31786210
Identified the Synergistic Mechanism of Drynariae Rhizoma for Treating Fracture Based on Network Pharmacology. PMID:31781279
An omics perspective on drug target discovery platforms. PMID:31774113
MicroRNA-101 Protects Against Cardiac Remodeling Following Myocardial Infarction via Downregulation of Runt-Related Transcription Factor 1. PMID:31766975
Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol through Integrated System Pharmacology and In Silico Analysis. PMID:31766220
Identifying gene function and module connections by the integration of multispecies expression compendia. PMID:31754022
Discovery of disease- and drug-specific pathways through community structures of a literature network. PMID:31738408
pathDIP 4: an extended pathway annotations and enrichment analysis resource for human, model organisms and domesticated species. PMID:31733064
PCOSBase: a manually curated database of polycystic ovarian syndrome. PMID:31725861
Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects. PMID:31705029
Identifying Cancer-Specific circRNA-RBP Binding Sites Based on Deep Learning. PMID:31703384
Gene- and Disease-Based Expansion of the Knowledge on Inborn Errors of Immunity. PMID:31695696
Proteomic Analysis of Urinary Extracellular Vesicles Reveals a Role for the Complement System in Medullary Sponge Kidney Disease. PMID:31694344
Understanding allergic multimorbidity within the non-eosinophilic interactome. PMID:31693680
CAUSALdb: a database for disease/trait causal variants identified using summary statistics of genome-wide association studies. PMID:31691819
Co-regulation map of the human proteome enables identification of protein functions. PMID:31690884
RareLSD: a manually curated database of lysosomal enzymes associated with rare diseases. PMID:31688938
'One DB to rule them all'-the RING: a Regulatory INteraction Graph combining TFs, genes/proteins, SNPs, diseases and drugs. PMID:31682269
The DisGeNET knowledge platform for disease genomics: 2019 update. PMID:31680165
Meta-Analysis of Gene Expression Changes in the Blood of Patients with Mild Cognitive Impairment and Alzheimer's Disease Dementia. PMID:31671574
The Computational Analysis Conducted on miRNA Target Sites in Association with SNPs at 3'UTR of ADHD-implicated Genes. PMID:31660846
Connections between 3' end processing and DNA damage response: Ten years later. PMID:31657151
The TargetMine Data Warehouse: Enhancement and Updates. PMID:31649722
ExonSkipDB: functional annotation of exon skipping event in human. PMID:31642488
Closing the Gap Between Therapeutic Use and Mode of Action in Remedial Herbs. PMID:31632273
Predicting circRNA-Disease Associations Based on Improved Collaboration Filtering Recommendation System With Multiple Data. PMID:31608124
Inferring Disease-Associated MicroRNAs Using Semi-supervised Multi-Label Graph Convolutional Networks. PMID:31605942
CancerGeneNet: linking driver genes to cancer hallmarks. PMID:31598703
QTLbase: an integrative resource for quantitative trait loci across multiple human molecular phenotypes. PMID:31598699
Debutant iOS app and gene-disease complexities in clinical genomics and precision medicine. PMID:31586224
Inferring Latent Disease-lncRNA Associations by Faster Matrix Completion on a Heterogeneous Network. PMID:31572428
Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. PMID:31536960
Enabling Web-scale data integration in biomedicine through Linked Open Data. PMID:31531395
Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach. PMID:31530902
Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina. PMID:31527661
A genome-wide screen for human salicylic acid (SA)-binding proteins reveals targets through which SA may influence development of various diseases. PMID:31511554
A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. PMID:31494632
Model annotation and discovery with the Physiome Model Repository. PMID:31492098
Crosstalk between microRNAs, the putative target genes and the lncRNA network in metabolic diseases. PMID:31485667
A Radiogenomic Approach for Decoding Molecular Mechanisms Underlying Tumor Progression in Prostate Cancer. PMID:31480766
GATA1 gene silencing inhibits invasion, proliferation and migration of cholangiocarcinoma stem cells via disrupting the PI3K/AKT pathway. PMID:31456644
Construction and Comprehensive Analysis of a Molecular Association Network via lncRNA-miRNA -Disease-Drug-Protein Graph. PMID:31405040
Network Diffusion Approach to Predict LncRNA Disease Associations Using Multi-Type Biological Networks: LION. PMID:31379598
Identification of Prognostic Biomarkers and Drugs Targeting Them in Colon Adenocarcinoma: A Bioinformatic Analysis. PMID:31370719
A Web Tool for Ranking Candidate Drugs Against a Selected Disease Based on a Combination of Functional and Structural Criteria. PMID:31360332
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases. PMID:31358043
Epigenetic alterations are associated with tumor mutation burden in non-small cell lung cancer. PMID:31349879
A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencing. PMID:31349857
Quantifying gene selection in cancer through protein functional alteration bias. PMID:31334812
Insights about multi-targeting and synergistic neuromodulators in Ayurvedic herbs against epilepsy: integrated computational studies on drug-target and protein-protein interaction networks. PMID:31332210
Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases. PMID:31323264
Spatiotemporal Gene Coexpression and Regulation in Mouse Cardiomyocytes of Early Cardiac Morphogenesis. PMID:31322043
Identifying potential drug targets in hepatocellular carcinoma based on network analysis and one-class support vector machine. PMID:31320657
CAGI5: Objective performance assessments of predictions based on the Evolutionary Action equation. PMID:31317604
PhenPath: a tool for characterizing biological functions underlying different phenotypes. PMID:31307376
NGSEA: Network-Based Gene Set Enrichment Analysis for Interpreting Gene Expression Phenotypes with Functional Gene Sets. PMID:31307154
Integrating biomedical research and electronic health records to create knowledge-based biologically meaningful machine-readable embeddings. PMID:31292438
Salivary Flow Alteration in Patients Undergoing Treatment for Schizophrenia: Disease-Drug-Target Gene/Protein Association Study for Side-effects. PMID:31289718
A genome-wide scan statistic framework for whole-genome sequence data analysis. PMID:31289270
Molecular mechanisms linking peri-implantitis and type 2 diabetes mellitus revealed by transcriptomic analysis. PMID:31275749
Identification of long non‑coding RNA‑mediated transcriptional dysregulation triplets reveals global patterns and prognostic biomarkers for ER+/PR+, HER2‑ and triple negative breast cancer. PMID:31257479
In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR. PMID:31244651
mTOR Signaling Pathway Regulates Sperm Quality in Older Men. PMID:31234465
Genetic Variation in Human Gene Regulatory Factors Uncovers Regulatory Roles in Local Adaptation and Disease. PMID:31228201
A linear delay algorithm for enumerating all connected induced subgraphs. PMID:31216984
Protein-Protein Interaction Network Analysis Reveals Several Diseases Highly Associated with Polycystic Ovarian Syndrome. PMID:31216618
Analysis of disease organ as a novel phenotype towards disease genetics understanding. PMID:31207382
The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthood. PMID:31204062
CoCoScore: context-aware co-occurrence scoring for text mining applications using distant supervision. PMID:31199464
Downregulated LRRK2 gene expression inhibits proliferation and migration while promoting the apoptosis of thyroid cancer cells by inhibiting activation of the JNK signaling pathway. PMID:31180559
A Fast and Flexible Framework for Network-Assisted Genomic Association. PMID:31174177
ResMarkerDB: a database of biomarkers of response to antibody therapy in breast and colorectal cancer. PMID:31169290
MENDA: a comprehensive curated resource of metabolic characterization in depression. PMID:31157825
Computational Advances in Drug Safety: Systematic and Mapping Review of Knowledge Engineering Based Approaches. PMID:31156424
Identifying mutation-driven changes in gene functionality that lead to venous thromboembolism. PMID:31144782
Identifying lncRNA-mediated regulatory modules via ChIA-PET network analysis. PMID:31142264
Predicting venous thromboembolism risk from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges. PMID:31140652
Drug repositioning of herbal compounds via a machine-learning approach. PMID:31138103
Comprehensive characterization of immune- and inflammation-associated biomarkers based on multi-omics integration in kidney renal clear cell carcinoma. PMID:31133033
Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets. PMID:31105872
Identification of Putative Regulatory Alterations Leading to Changes in Gene Expression in Chronic Obstructive Pulmonary Disease. PMID:31085807
g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). PMID:31066453
Plasma protein biomarkers and their association with mutually exclusive cardiovascular phenotypes: the FIBRO-TARGETS case-control analyses. PMID:31062082
Differential expression and bioinformatics analysis of circRNA in osteosarcoma. PMID:31036604
Genetic Predispositions of Glucocorticoid Resistance and Therapeutic Outcomes in Polymyalgia Rheumatica and Giant Cell Arteritis. PMID:31035618
Network Medicine in the Age of Biomedical Big Data. PMID:31031797
A bioinformatics investigation into the pharmacological mechanisms of the effect of Fufang Danshen on pain based on methodologies of network pharmacology. PMID:30976033
In silico Characterization of Human Prion-Like Proteins: Beyond Neurological Diseases. PMID:30971948
Building the drug-GO function network to screen significant candidate drugs for myasthenia gravis. PMID:30947317
Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data. PMID:30914061
Measuring the importance of vertices in the weighted human disease network. PMID:30901770
Identifying miRNA-mRNA regulatory relationships in breast cancer with invariant causal prediction. PMID:30876399
Long Noncoding RNA and Protein Interactions: From Experimental Results to Computational Models Based on Network Methods. PMID:30875752
Prioritization of genes involved in endothelial cell apoptosis by their implication in lymphedema using an analysis of associative gene networks with ANDSystem. PMID:30871556
Increased intron retention is a post-transcriptional signature associated with progressive aging and Alzheimer's disease. PMID:30868713
GenCoNet - A Graph Database for the Analysis of Comorbidities by Gene Networks. PMID:30864352
Geometric characterisation of disease modules. PMID:30839777
Compendium of synovial signatures identifies pathologic characteristics for predicting treatment response in rheumatoid arthritis patients. PMID:30831253
Isoform-specific GSK3A activity is negatively correlated with human sperm motility. PMID:30824926
Synergy from gene expression and network mining (SynGeNet) method predicts synergistic drug combinations for diverse melanoma genomic subtypes. PMID:30820351
Prediction of Drug Positioning for Quan-Du-Zhong Capsules Against Hypertensive Nephropathy Based on the Robustness of Disease Network. PMID:30809144
hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids. PMID:30799279
Evolutionary Loss of Genomic Proximity to Conserved Noncoding Elements Impacted the Gene Expression Dynamics During Mammalian Brain Development. PMID:30796012
A Network Pharmacology Approach to Explore Mechanism of Action of Longzuan Tongbi Formula on Rheumatoid Arthritis. PMID:30792744
Prediction of lncRNA-disease associations by integrating diverse heterogeneous information sources with RWR algorithm and positive pointwise mutual information. PMID:30782113
Transcriptome dataset of trunk neural crest cells migrating along the ventral pathway of chick embryos. PMID:30761336
CeModule: an integrative framework for discovering regulatory patterns from genomic data in cancer. PMID:30732558
Systematically Characterizing Chemical Profile and Potential Mechanisms of Qingre Lidan Decoction Acting on Cholelithiasis by Integrating UHPLC-QTOF-MS and Network Target Analysis. PMID:30719056
Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors. PMID:30696729
Region-resolved proteomics profiling of monkey heart. PMID:30644093
Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set. PMID:30602777
Integrating node embeddings and biological annotations for genes to predict disease-gene associations. PMID:30598097
Early-onset inflammatory bowel disease as a model disease to identify key regulators of immune homeostasis mechanisms. PMID:30565237
Integrating molecular networks with genetic variant interpretation for precision medicine. PMID:30548534
PathFX provides mechanistic insights into drug efficacy and safety for regulatory review and therapeutic development. PMID:30532240
Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury. PMID:30515189
Identification of drug repurposing candidates based on a miRNA-mediated drug and pathway network for cardiac hypertrophy and acute myocardial infarction. PMID:30514363
Open Targets Platform: new developments and updates two years on. PMID:30462303
Transcriptomic Characterization of the Human Habenula Highlights Drug Metabolism and the Neuroimmune System. PMID:30429765
HumanNet v2: human gene networks for disease research. PMID:30418591
IID 2018 update: context-specific physical protein-protein interactions in human, model organisms and domesticated species. PMID:30407591
FusionGDB: fusion gene annotation DataBase. PMID:30407583
BioInstaller: a comprehensive R package to construct interactive and reproducible biological data analysis applications based on the R platform. PMID:30402350
Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population. PMID:30402224
Disease networks identify specific conditions and pleiotropy influencing multimorbidity in the general population. PMID:30374096
TransmiR v2.0: an updated transcription factor-microRNA regulation database. PMID:30371815
Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia. PMID:30365130
HMDD v3.0: a database for experimentally supported human microRNA-disease associations. PMID:30364956
Quantitative and systems pharmacology 4. Network-based analysis of drug pleiotropy on coronary artery disease. PMID:30359818
Genome-wide significant regions in 43 Utah high-risk families implicate multiple genes involved in risk for completed suicide. PMID:30353169
Network, Transcriptomic and Genomic Features Differentiate Genes Relevant for Drug Response. PMID:30319692
Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands. PMID:30285606
Positive and balancing selection on SLC18A1 gene associated with psychiatric disorders and human-unique personality traits. PMID:30283697
Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease. PMID:30226566
Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease. PMID:30224808
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. PMID:30224653
Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles. PMID:30219839
LncRNA TUG1 promotes cells proliferation and inhibits cells apoptosis through regulating AURKA in epithelial ovarian cancer cells. PMID:30200102
Using predicate and provenance information from a knowledge graph for drug efficacy screening. PMID:30189889
Rare gene deletions in genetic generalized and Rolandic epilepsies. PMID:30148849
System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia. PMID:30127739
Computational resources associating diseases with genotypes, phenotypes and exposures. PMID:30102366
On entropy and information in gene interaction networks. PMID:30102349
A Network Pharmacology-Based Analysis of Multi-Target, Multi-Pathway, Multi-Compound Treatment for Ovarian Serous Cystadenocarcinoma. PMID:30097905
Celiac disease biomarkers identified by transcriptome analysis of small intestinal biopsies. PMID:30097691
Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography. PMID:30082915
Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer's Disease. PMID:30050590
Automatic extraction of gene-disease associations from literature using joint ensemble learning. PMID:30048465
Using Multi-Scale Genetic, Neuroimaging and Clinical Data for Predicting Alzheimer's Disease and Reconstruction of Relevant Biological Mechanisms. PMID:30042519
Comprehensive identification of immune-associated biomarkers based on network and mRNA expression patterns in membranous glomerulonephritis. PMID:30041664
A Novel Probability Model for LncRNA⁻Disease Association Prediction Based on the Naïve Bayesian Classifier. PMID:29986541
Network-based association analysis to infer new disease-gene relationships using large-scale protein interactions. PMID:29949603
Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology. PMID:29932108
comoRbidity: an R package for the systematic analysis of disease comorbidities. PMID:29897411
CoNVaQ: a web tool for copy number variation-based association studies. PMID:29776329
Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine. PMID:29765977
Metformin directly targets the H3K27me3 demethylase KDM6A/UTX. PMID:29740925
MECP2 variation in Rett syndrome-An overview of current coverage of genetic and phenotype data within existing databases. PMID:29704307
Post genome-wide association analysis: dissecting computational pathway/network-based approaches. PMID:29701762
miR-103 Promotes Neurite Outgrowth and Suppresses Cells Apoptosis by Targeting Prostaglandin-Endoperoxide Synthase 2 in Cellular Models of Alzheimer's Disease. PMID:29674956
Detecting Disease Specific Pathway Substructures through an Integrated Systems Biology Approach. PMID:29657291
Bipartite graphs in systems biology and medicine: a survey of methods and applications. PMID:29648623
The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity. PMID:29631359
From SNPs to pathways: Biological interpretation of type 2 diabetes (T2DM) genome wide association study (GWAS) results. PMID:29617380
Systematic Evaluation of Molecular Networks for Discovery of Disease Genes. PMID:29605183
Protein-protein interaction analysis of Alzheimer`s disease and NAFLD based on systems biology methods unhide common ancestor pathways. PMID:29564062
IMPPAT: A curated database of Indian Medicinal Plants, Phytochemistry And Therapeutics. PMID:29531263
Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks. PMID:29504915
Long non-coding RNA RP11-552M11.4 promotes cells proliferation, migration and invasion by targeting BRCA2 in ovarian cancer. PMID:29478268
Leveraging human genetic and adverse outcome pathway (AOP) data to inform susceptibility in human health risk assessment. PMID:29476236
A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures. PMID:29474920
AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks. PMID:29454060
Lnc2Catlas: an atlas of long noncoding RNAs associated with risk of cancers. PMID:29382910
An integrative functional genomics framework for effective identification of novel regulatory variants in genome-phenome studies. PMID:29378629
MiRNA-mRNA crosstalk in laryngeal squamous cell carcinoma based on the TCGA database. PMID:29332170
A census of P. longum's phytochemicals and their network pharmacological evaluation for identifying novel drug-like molecules against various diseases, with a special focus on neurological disorders. PMID:29320554
Sulfonanilide Derivatives in Identifying Novel Aromatase Inhibitors by Applying Docking, Virtual Screening, and MD Simulations Studies. PMID:29312992
Simultaneous inference of phenotype-associated genes and relevant tissues from GWAS data via Bayesian integration of multiple tissue-specific gene networks. PMID:29300920
Genome variation and conserved regulation identify genomic regions responsible for strain specific phenotypes in rat. PMID:29272997
Personal Cancer Genome Reporter: variant interpretation report for precision oncology. PMID:29272339
The integration of weighted gene association networks based on information entropy. PMID:29272314
Query expansion using MeSH terms for dataset retrieval: OHSU at the bioCADDIE 2016 dataset retrieval challenge. PMID:29220467
Text mining and expert curation to develop a database on psychiatric diseases and their genes. PMID:29220439
Properties of human genes guided by their enrichment in rare and common variants. PMID:29197136
Estimation of the proteomic cancer co-expression sub networks by using association estimators. PMID:29145449
PedAM: a database for Pediatric Disease Annotation and Medicine. PMID:29126123
A systems biology analysis protein-protein interaction of NASH and IBD based on comprehensive gene information. PMID:29118935
eRAM: encyclopedia of rare disease annotations for precision medicine. PMID:29106618
A deep ensemble model to predict miRNA-disease association. PMID:29101378
Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers. PMID:29058630
The online Tabloid Proteome: an annotated database of protein associations. PMID:29040688
DISNOR: a disease network open resource. PMID:29036667
TissGDB: tissue-specific gene database in cancer. PMID:29036590
tmVar 2.0: integrating genomic variant information from literature with dbSNP and ClinVar for precision medicine. PMID:28968638
psygenet2r: a R/Bioconductor package for the analysis of psychiatric disease genes. PMID:28961763
Orthologue chemical space and its influence on target prediction. PMID:28961699
Systematic integration of biomedical knowledge prioritizes drugs for repurposing. PMID:28936969
Extracellular vesicle-packaged miRNA release after short-term exposure to particulate matter is associated with increased coagulation. PMID:28899404
Domain-based prediction of the human isoform interactome provides insights into the functional impact of alternative splicing. PMID:28846689
eDGAR: a database of Disease-Gene Associations with annotated Relationships among genes. PMID:28812536
Reverse Nearest Neighbor Search on a Protein-Protein Interaction Network to Infer Protein-Disease Associations. PMID:28757797
Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling. PMID:28701918
HGPEC: a Cytoscape app for prediction of novel disease-gene and disease-disease associations and evidence collection based on a random walk on heterogeneous network. PMID:28619054
Distinct DNA methylation profiles in subtypes of orofacial cleft. PMID:28603561
Using ChEMBL web services for building applications and data processing workflows relevant to drug discovery. PMID:28602100
Cross-Kingdom Regulation of Putative miRNAs Derived from Happy Tree in Cancer Pathway: A Systems Biology Approach. PMID:28587194
A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data. PMID:28569218
Bioinformatics in translational drug discovery. PMID:28487472
WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit. PMID:28472511
Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations. PMID:28469556
Open Targets: a platform for therapeutic target identification and validation. PMID:27899665
The DisGeNET knowledge platform for disease genomics: 2019 update PubMed citations: 433.

433 articles citing: The DisGeNET knowledge platform for disease genomics: 2019 update

Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder. PMID:35922419
Antidepressant Mechanism of Kaixinsan and Its Active Compounds Based on Upregulation of Antioxidant Thioredoxin. PMID:35911169
Biological interacting units identified in human protein networks reveal tissue-functional diversification and its impact on disease. PMID:35891788
Repurposing Drugs via Network Analysis: Opportunities for Psychiatric Disorders. PMID:35890359
Exploring Quercetin Anti-Osteoporosis Pharmacological Mechanisms with In Silico and In Vivo Models. PMID:35888070
Functional Genomics Analysis to Disentangle the Role of Genetic Variants in Major Depression. PMID:35886042
Network Proximity-Based Drug Repurposing Strategy for Early and Late Stages of Primary Biliary Cholangitis. PMID:35884999
Active ingredients and molecular targets of Taraxacum mongolicum against hepatocellular carcinoma: network pharmacology, molecular docking, and molecular dynamics simulation analysis. PMID:35873910
Unravelling genetic variants of a swedish family with high risk of prostate cancer. PMID:35870994
orsum: a Python package for filtering and comparing enrichment analyses using a simple principle. PMID:35870894
Qing`e Pill Inhibits Osteoblast Ferroptosis via ATM Serine/Threonine Kinase (ATM) and the PI3K/AKT Pathway in Primary Osteoporosis. PMID:35865965
NTD-DR: Nonnegative tensor decomposition for drug repositioning. PMID:35862409
Traumatic MicroRNAs: Deconvolving the Signal After Severe Traumatic Brain Injury. PMID:35852739
Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer's disease. PMID:35849618
HumanMine: advanced data searching, analysis and cross-species comparison. PMID:35820040
Qin Huang formula enhances the effect of Adriamycin in B-cell lymphoma via increasing tumor infiltrating lymphocytes by targeting toll-like receptor signaling pathway. PMID:35818037
Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Berberine in the Treatment of Ischaemic Stroke. PMID:35815278
The Potential Mechanisms of Cinobufotalin Treating Colon Adenocarcinoma by Network Pharmacology. PMID:35814224
Network Pharmacology and In Vivo Experimental Validation to Uncover the Renoprotective Mechanisms of Fangji Huangqi Decoction on Nephrotic Syndrome. PMID:35722158
Brevilin A Isolated from Centipeda minima Induces Apoptosis in Human Gastric Cancer Cells via an Extrinsic Apoptotic Signaling Pathway. PMID:35807611
Network-Based Approaches for Disease-Gene Association Prediction Using Protein-Protein Interaction Networks. PMID:35806415
Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis. PMID:35792766
A network pharmacology approach to explore and validate the potential targets of ginsenoside on osteoporosis. PMID:35791093
[Therapeutic mechanism of emodin for treatment of rheumatoid arthritis: a network pharmacology-based analysis]. PMID:35790443
Exploring the Mechanism of Hawthorn Leaves Against Coronary Heart Disease Using Network Pharmacology and Molecular Docking. PMID:35783840
Deeper insights into long-term survival heterogeneity of pancreatic ductal adenocarcinoma (PDAC) patients using integrative individual- and group-level transcriptome network analyses. PMID:35773268
Differential vulnerability of anterior cingulate cortex cell types to diseases and drugs. PMID:35754044
Exploring the possible molecular targeting mechanism of Saussurea involucrata in the treatment of COVID-19 based on bioinformatics and network pharmacology. PMID:35751193
Spatio-temporal dynamics of pathogenic variants associated with monogenic disorders reconstructed with ancient DNA. PMID:35749392
TCGA-My: A Systematic Repository for Systems Biology of Malaysian Colorectal Cancer. PMID:35743803
Network pharmacology integrated molecular dynamics reveals the bioactive compounds and potential targets of Tinospora crispa Linn. as insulin sensitizer. PMID:35737707
mGWAS-Explorer: Linking SNPs, Genes, Metabolites, and Diseases for Functional Insights. PMID:35736459
Deepening the knowledge of rare diseases dependent on angiogenesis through semantic similarity clustering and network analysis. PMID:35731990
Protective Effects and Mechanisms of Yinchen Linggui Zhugan Decoction in HFD-Induced Nonalcoholic Fatty Liver Disease Rats Based on Network Pharmacology and Experimental Verification. PMID:35721171
Bioinformatics and System Biology Approach to Reveal the Interaction Network and the Therapeutic Implications for Non-Small Cell Lung Cancer Patients With COVID-19. PMID:35721149
SFARI genes and where to find them; modelling Autism Spectrum Disorder specific gene expression dysregulation with RNA-seq data. PMID:35710789
A Computational Data Mining Strategy to Identify the Common Genetic Markers of Temporomandibular Joint Disorders and Osteoarthritis. PMID:35707787
Calycosin prevents IL-1β-induced articular chondrocyte damage in osteoarthritis through regulating the PI3K/AKT/FoxO1 pathway. PMID:35705795
Network approaches for modeling the effect of drugs and diseases. PMID:35704883
Exploration of the Mechanism of Salvianolic Acid for Injection Against Ischemic Stroke: A Research Based on Computational Prediction and Experimental Validation. PMID:35694259
Pharmacological mechanisms of sodium-glucose co-transporter 2 inhibitors in heart failure with preserved ejection fraction. PMID:35689186
DisPhaseDB: An integrative database of diseases related variations in liquid-liquid phase separation proteins. PMID:35685370
Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach. PMID:35676267
Exploring the comorbidity mechanisms between asthma and idiopathic pulmonary fibrosis and the pharmacological mechanisms of Bu-Shen-Yi-Qi decoction therapy via network pharmacology. PMID:35672815
Network pharmacology and experimental verification based research into the effect and mechanism of Aucklandiae Radix-Amomi Fructus against gastric cancer. PMID:35672352
A Network Pharmacology Analysis of Cytotoxic Triterpenes Isolated from Euphorbia abyssinica Latex Supported by Drug-likeness and ADMET Studies. PMID:35664578
Dysregulation of microRNAs and tRNA-derived ncRNAs in mesothelial and mesothelioma cell lines after asbestiform fiber exposure. PMID:35654808
Medication Rules in Herbal Medicine for Mild Cognitive Impairment: A Network Pharmacology and Data Mining Study. PMID:35646138
Resveratrol Ameliorates Lipopolysaccharide-Induced Sudden Sensorineural Hearing Loss in In Vitro Model through Multitarget Antiapoptotic Mechanism Based on Network Pharmacology and Molecular Docking. PMID:35646137
Deciphering the Effects and Mechanisms of Yi-Fei-San-Jie-pill on Non-Small Cell Lung Cancer With Integrating Network Target Analysis and Experimental Validation. PMID:35645820
Whole-Genome Sequencing of 100 Genomes Identifies a Distinctive Genetic Susceptibility Profile of Qatari Patients with Hypertension. PMID:35629146
DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease. PMID:35626643
Transcriptomal Insights of Heart Failure from Normality to Recovery. PMID:35625658
Mechanism of Fructus Mume Pills Underlying Their Protective Effects in Rats with Acetic Acid-Inducedulcerative Colitis via the Regulation of Inflammatory Cytokines and the VEGF-PI3K/Akt-eNOS Signaling Pathway. PMID:35620404
Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. PMID:35617485
A Simple Standard for Sharing Ontological Mappings (SSSOM). PMID:35616100
Identifying drivers of breast cancer metastasis in progressively invasive subpopulations of zebrafish-xenografted MDA-MB-231. PMID:35614362
Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain. PMID:35614064
Integrated Gut-Heart Axis and Network Pharmacology to Reveal the Mechanisms of the Huoxue Wentong Formula Against Myocardial Ischemia. PMID:35600966
Mechanism of Peitu Shengjin Formula Shenlingbaizhu Powder in Treating Bronchial Asthma and Allergic Colitis through Different Diseases with Simultaneous Treatment Based on Network Pharmacology and Molecular Docking. PMID:35586697
Clinical Evidence and Potential Mechanisms of Complementary Treatment of Ling Gui Zhu Gan Formula for the Management of Serum Lipids and Obesity. PMID:35586687
Brief Developmental Exposure to Fluoxetine Causes Life-Long Alteration of the Brain Transcriptome in Zebrafish. PMID:35573988
BioTAGME: A Comprehensive Platform for Biological Knowledge Network Analysis. PMID:35571058
Chemical Diversity and Potential Target Network of Woody Peony Flower Essential Oil from Eleven Representative Cultivars (Paeonia × suffruticosa Andr.). PMID:35566179
A Novel Machine Learning 13-Gene Signature: Improving Risk Analysis and Survival Prediction for Clear Cell Renal Cell Carcinoma Patients. PMID:35565241
Enhancer RNA AL928768.3 from the IGH Locus Regulates MYC Expression and Controls the Proliferation and Chemoresistance of Burkitt Lymphoma Cells with IGH/MYC Translocation. PMID:35563017
SynLethDB 2.0: a web-based knowledge graph database on synthetic lethality for novel anticancer drug discovery. PMID:35562840
A Community-Driven, Openly Accessible Molecular Pathway Integrating Knowledge on Malignant Pleural Mesothelioma. PMID:35558518
pubmedKB: an interactive web server for exploring biomedical entity relations in the biomedical literature. PMID:35536289
Network Pharmacology and Molecular Docking-Based Strategy to Investigate the Multitarget Mechanisms of Shenqi Yizhi Granule on Alzheimer's Disease. PMID:35535155
Network pharmacology of iridoid glycosides from Eucommia ulmoides Oliver against osteoporosis. PMID:35523810
Integrated Network Pharmacology and Metabolomics Analysis to Reveal the Potential Mechanism of Siwu Paste on Aplastic Anemia Induced by Chemotherapy Drugs. PMID:35517983
A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets. PMID:35513850
A game changer for bipolar disorder diagnosis using RNA editing-based biomarkers. PMID:35504874
Bringing machine learning to research on intellectual and developmental disabilities: taking inspiration from neurological diseases. PMID:35501679
Discovery of Novel Drug Candidates for Alzheimer's Disease by Molecular Network Modeling. PMID:35493947
Dan-Shen-Yin Granules Prevent Hypoxia-Induced Pulmonary Hypertension via STAT3/HIF-1α/VEGF and FAK/AKT Signaling Pathways. PMID:35479305
The mid-secretory endometrial transcriptomic landscape in endometriosis: a meta-analysis. PMID:35464885
Bioinformatics and System Biology Approach to Identify the Influences of COVID-19 on Rheumatoid Arthritis. PMID:35464423
Artificial Intelligence Uncovers Natural MMP Inhibitor Crocin as a Potential Treatment of Thoracic Aortic Aneurysm and Dissection. PMID:35463768
Application of Proteogenomics to Urine Analysis towards the Identification of Novel Biomarkers of Prostate Cancer: An Exploratory Study. PMID:35454907
Darling: A Web Application for Detecting Disease-Related Biomedical Entity Associations with Literature Mining. PMID:35454109
Comprehensive network medicine-based drug repositioning via integration of therapeutic efficacy and side effects. PMID:35443763
Identification of potential pathogenic genes for severe aplastic anemia by whole-exome sequencing. PMID:35435273
Co-expression analysis to identify key modules and hub genes associated with COVID-19 in platelets. PMID:35421970
A Comparison of Network-Based Methods for Drug Repurposing along with an Application to Human Complex Diseases. PMID:35409062
Polyploidy as a Fundamental Phenomenon in Evolution, Development, Adaptation and Diseases. PMID:35408902
The Anti-Constipation Effects of Raffino-Oligosaccharide on Gut Function in Mice Using Neurotransmitter Analyses, 16S rRNA Sequencing and Targeted Screening. PMID:35408632
Investigation of the Effect of Curcumin on Protein Targets in NAFLD Using Bioinformatic Analysis. PMID:35405942
Construction of disease-specific cytokine profiles by associating disease genes with immune responses. PMID:35404985
Network Pharmacologic Analysis of Dendrobium officinale Extract Inhibiting the Proliferation of Gastric Cancer Cells. PMID:35401206
Efficacy and Pharmacological Mechanism of Poria cocos-Based Formulas Combined With Chemotherapy for Ovarian Cancer: A Integrated Systems Pharmacology Study. PMID:35401186
A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Rhizoma Dioscoreae Nipponicae in the Treatment of Asthma. PMID:35399637
RGMQL: scalable and interoperable computing of heterogeneous omics big data and metadata in R/Bioconductor. PMID:35392801
Identification of host transcriptome-guided repurposable drugs for SARS-CoV-1 infections and their validation with SARS-CoV-2 infections by using the integrated bioinformatics approaches. PMID:35390032
Providing Adverse Outcome Pathways from the AOP-Wiki in a Semantic Web Format to Increase Usability and Accessibility of the Content. PMID:35388368
Molecular Mechanism Underlying Effects of Wumeiwan on Steroid-Dependent Asthma: A Network Pharmacology, Molecular Docking, and Experimental Verification Study. PMID:35386850
Expansion of Schizophrenia Gene Network Knowledge Using Machine Learning Selected Signals From Dorsolateral Prefrontal Cortex and Amygdala RNA-seq Data. PMID:35386517
Analysis of Gene-Environment Interactions Related to Developmental Disorders. PMID:35370658
TBGA: a large-scale Gene-Disease Association dataset for Biomedical Relation Extraction. PMID:35361129
Application of Transcriptomics for Predicting Protein Interaction Networks, Drug Targets and Drug Candidates. PMID:35356062
Elucidating the Synergistic Effect of Multiple Chinese Herbal Prescriptions in the Treatment of Post-stroke Neurological Damage. PMID:35355727
Diseases 2.0: a weekly updated database of disease-gene associations from text mining and data integration. PMID:35348648
Mitigation of Gastric Damage Using Cinnamomum cassia Extract: Network Pharmacological Analysis of Active Compounds and Protection Effects in Rats. PMID:35336597
Uncovering the Pharmacological Mechanisms of Gexia-Zhuyu Formula (GXZY) in Treating Liver Cirrhosis by an Integrative Pharmacology Strategy. PMID:35330838
Functional Enrichment Analysis of Regulatory Elements. PMID:35327392
Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes. PMID:35321029
Analysis of Genes Associated with Both Neural Tube Defects and Neuroectodermal Tumors. PMID:35318299
Novel prevention insights into depletion of oxidative stress status through regular exercise and grape seed effective substance in heart ischemia rat model. PMID:35311161
Human pancreatic islet miRNA-mRNA networks of altered miRNAs due to glycemic status. PMID:35310942
Unsuppressed Striatal Activity and Genetic Risk for Schizophrenia Associated With Individual Cognitive Performance Under Social Competition. PMID:35307738
Beacon v2 and Beacon networks: A "lingua franca" for federated data discovery in biomedical genomics, and beyond. PMID:35297548
Network Pharmacology and Molecular Docking Elucidate the Pharmacological Mechanism of the OSTEOWONDER Capsule for Treating Osteoporosis. PMID:35295951
Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis. PMID:35287308
Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing. PMID:35277538
A Hybrid Machine Learning and Network Analysis Approach Reveals Two Parkinson's Disease Subtypes from 115 RNA-Seq Post-Mortem Brain Samples. PMID:35269707
In silico drug repositioning based on integrated drug targets and canonical correlation analysis. PMID:35249529
Chinese herbal decoction astragalus and angelica exerts its therapeutic effect on renal interstitial fibrosis through the inhibition of MAPK, PI3K-Akt and TNF signaling pathways. PMID:35224164
Inferring Retinal Degeneration-Related Genes Based on Xgboost. PMID:35223997
Mapping the gene network landscape of Alzheimer's disease through integrating genomics and transcriptomics. PMID:35213535
African Genomic Medicine Portal: A Web Portal for Biomedical Applications. PMID:35207753
Network Pharmacology Study to Reveal the Potentiality of a Methanol Extract of Caesalpinia sappan L. Wood against Type-2 Diabetes Mellitus. PMID:35207564
Development of Gene Expression-Based Random Forest Model for Predicting Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancer. PMID:35205629
Phosphoproteomic Analysis of Breast Cancer-Derived Small Extracellular Vesicles Reveals Disease-Specific Phosphorylated Enzymes. PMID:35203617
Human bronchial epithelial cells from patients with asthma have an altered gene expression profile. PMID:35198626
Network pharmacology analysis and molecular docking to unveil the potential mechanisms of San-Huang-Chai-Zhu formula treating cholestasis. PMID:35196362
Comprehensive Network Analysis Identified SIRT7, NTRK2, and CHI3L1 as New Potential Markers for Intervertebral Disc Degeneration. PMID:35190738
Pseudoautosomal Region 1 Overdosage Affects the Global Transcriptome in iPSCs From Patients With Klinefelter Syndrome and High-Grade X Chromosome Aneuploidies. PMID:35186953
Integrative OMICS Data-Driven Procedure Using a Derivatized Meta-Analysis Approach. PMID:35186042
Progesterone Inhibits the Establishment of Activation-Associated Chromatin During TH1 Differentiation. PMID:35185927
The RD-Connect Genome-Phenome Analysis Platform: Accelerating diagnosis, research, and gene discovery for rare diseases. PMID:35178824
A Network Pharmacology Study on the Active Components and Targets of the Radix Ginseng and Radix Bupleuri Herb Pair for Treating Nonalcoholic Fatty Liver Disease. PMID:35178098
Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes. PMID:35175464
Revealing Cavin-2 Gene Function in Lung Based on Multi-Omics Data Analysis Method. PMID:35174175
Deciphering the involvement of iron targets in colorectal cancer: a network biology approach. PMID:35173863
Significant modulations of linc001128 and linc0938 with miR-24-3p and miR-30c-5p in Parkinson disease. PMID:35173238
Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification. PMID:35170400
CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system. PMID:35156780
Human Immune System Diseasome Networks and Female Oviductal Microenvironment: New Horizons to be Discovered. PMID:35154249
Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry. PMID:35150639
Genome-wide RNAi screen identifies novel players in human 60S subunit biogenesis including key enzymes of polyamine metabolism. PMID:35150276
Altered Circulating MicroRNA Profiles After Endurance Training: A Cohort Study of Ultramarathon Runners. PMID:35145424
Diosgenin From Dioscorea Nipponica Rhizoma Against Graves' Disease-On Network Pharmacology and Experimental Evaluation. PMID:35140607
Interpretable network-guided epistasis detection. PMID:35134928
Identification of circular RNAs and functional competing endogenous RNA networks in human proximal tubular epithelial cells treated with sodium-glucose cotransporter 2 inhibitor dapagliflozin in diabetic kidney disease. PMID:35129424
A Systematic Analysis on the Genes and Their Interaction Underlying the Comorbidity of Alzheimer's Disease and Major Depressive Disorder. PMID:35126089
A knowledge graph to interpret clinical proteomics data. PMID:35102292
A network pharmacology approach to predict potential targets and mechanisms of "Ramulus Cinnamomi (cassiae) - Paeonia lactiflora" herb pair in the treatment of chronic pain with comorbid anxiety and depression. PMID:35098831
Large-Scale Gastric Cancer Susceptibility Gene Identification Based on Gradient Boosting Decision Tree. PMID:35096975
Evaluating Eosinophilic Colitis as a Unique Disease Using Colonic Molecular Profiles: A Multi-Site Study. PMID:35085569
Ontology-based identification and prioritization of candidate drugs for epilepsy from literature. PMID:35073996
Epigenetic landscape of drug responses revealed through large-scale ChIP-seq data analyses. PMID:35073843
The structural coverage of the human proteome before and after AlphaFold. PMID:35073311
Associations Among PCSK9 Levels, Atherosclerosis-Derived Extracellular Vesicles, and Their miRNA Content in Adults With Obesity. PMID:35071356
Identification of putative genetic variants in major depressive disorder patients in Pakistan. PMID:35040003
NETME: on-the-fly knowledge network construction from biomedical literature. PMID:35013714
Single-cell chromatin accessibility landscape in kidney identifies additional cell-of-origin in heterogenous papillary renal cell carcinoma. PMID:35013217
A network-based integration for understanding racial disparity in prostate cancer. PMID:34998235
Target Deconvolution of Fenofibrate in Nonalcoholic Fatty Liver Disease Using Bioinformatics Analysis. PMID:34988225
Prediction of lncRNA-disease association based on a Laplace normalized random walk with restart algorithm on heterogeneous networks. PMID:34983367
Qingwei San treats oral ulcer subjected to stomach heat syndrome in db/db mice by targeting TLR4/MyD88/NF-κB pathway. PMID:34980192
Impact of Qi-Invigorating Traditional Chinese Medicines on Diffuse Large B Cell Lymphoma Based on Network Pharmacology and Experimental Validation. PMID:34955857
Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses. PMID:34955724
In Silico Investigation of the Biological Implications of Complex DNA Damage with Emphasis in Cancer Radiotherapy through a Systems Biology Approach. PMID:34946681
8-Hydroxydaidzein Downregulates JAK/STAT, MMP, Oxidative Phosphorylation, and PI3K/AKT Pathways in K562 Cells. PMID:34944720
Combined Anti-Adipogenic Effects of Hispidulin and p-Synephrine on 3T3-L1 Adipocytes. PMID:34944408
Anticancer Action of Xiaoxianxiong Tang in Non-Small Cell Lung Cancer by Pharmacological Analysis and Experimental Validation. PMID:34938346
Pan-cancer classification by regularized multi-task learning. PMID:34930937
Network Integration Analysis and Immune Infiltration Analysis Reveal Potential Biomarkers for Primary Open-Angle Glaucoma. PMID:34926471
Protein network analysis to prioritize key genes in amyotrophic lateral sclerosis. PMID:34918006
XDeathDB: a visualization platform for cell death molecular interactions. PMID:34907160
Identification of homologous human miRNAs as antivirals towards COVID-19 genome. PMID:34901760
Shared Molecular Mechanisms between Atherosclerosis and Periodontitis by Analyzing the Transcriptomic Alterations of Peripheral Blood Monocytes. PMID:34899963
Graph Embedding Based Novel Gene Discovery Associated With Diabetes Mellitus. PMID:34899863
Identifying imaging genetic associations via regional morphometricity estimation. PMID:34890140
Predicting deleterious missense genetic variants via integrative supervised nonnegative matrix tri-factorization. PMID:34887492
Exploration of Dark Chemical Genomics Space via Portal Learning: Applied to Targeting the Undruggable Genome and COVID-19 Anti-Infective Polypharmacology. PMID:34873596
Potential Molecular Targets of Tenofovir Disoproxil Fumarate for Alleviating Chronic Liver Diseases via a Non-Antiviral Effect in a Normal Mouse Model. PMID:34869594
LIMD2 is a Prognostic and Predictive Marker in Patients With Esophageal Cancer Based on a ceRNA Network Analysis. PMID:34868263
Applications of the SR4G Transgenic Zebrafish Line for Biomonitoring of Stress-Disrupting Compounds: A Proof-of-Concept Study. PMID:34867778
Exploring cell-specific miRNA regulation with single-cell miRNA-mRNA co-sequencing data. PMID:34856921
CircNet 2.0: an updated database for exploring circular RNA regulatory networks in cancers. PMID:34850139
Diversity and molecular network patterns of symptom phenotypes. PMID:34848731
Uncovering the action mechanism of homoharringtonine against colorectal cancer by using network pharmacology and experimental evaluation. PMID:34847838
Pathway Enrichment Analysis of Microarray Data Fom Human Penis of Diabetic and Peyronie's Patients, in Comparison With Diabetic Rat Erectile Dysfunction Models. PMID:34838480
Overexpression of melanoma-associated antigen A2 has a clinical significance in embryonal carcinoma and is associated with tumor progression. PMID:34837545
Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans. PMID:34832615
Network medicine for disease module identification and drug repurposing with the NeDRex platform. PMID:34824199
Annotating and prioritizing genomic variants using the Ensembl Variant Effect Predictor-A tutorial. PMID:34816521
Identification of Immunological Biomarkers of Atopic Dermatitis by Integrated Analysis to Determine Molecular Targets for Diagnosis and Therapy. PMID:34815693
Molecular and in vivo phenotyping of missense variants of the human glucagon receptor. PMID:34801547
HFIP: an integrated multi-omics data and knowledge platform for the precision medicine of heart failure. PMID:34791105
MoG+: a database of genomic variations across three mouse subspecies for biomedical research. PMID:34782917
Growth of Biological Complexity from Prokaryotes to Hominids Reflected in the Human Genome. PMID:34769071
IID 2021: towards context-specific protein interaction analyses by increased coverage, enhanced annotation and enrichment analysis. PMID:34755877
HumanNet v3: an improved database of human gene networks for disease research. PMID:34747468
BDdb: a comprehensive platform for exploration and utilization of birth defect multi-omics data. PMID:34736471
Identification of a Putative Enhancer RNA for EGFR in Hyper-Accessible Regions in Esophageal Squamous Cell Carcinoma Cells by Analysis of Chromatin Accessibility Landscapes. PMID:34722266
TcoFBase: a comprehensive database for decoding the regulatory transcription co-factors in human and mouse. PMID:34718747
RNAPhaSep: a resource of RNAs undergoing phase separation. PMID:34718740
RPS: a comprehensive database of RNAs involved in liquid-liquid phase separation. PMID:34718734
Centrality of drug targets in protein networks. PMID:34715787
A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease. PMID:34712920
Magnolol upregulates CHRM1 to attenuate Amyloid-β-triggered neuronal injury through regulating the cAMP/PKA/CREB pathway. PMID:34705126
Classifying diseases by using biological features to identify potential nosological models. PMID:34702888
Network Pharmacology-Based Strategy to Investigate Pharmacological Mechanisms of the Drug Pair Astragalus-Angelica for Treatment of Male Infertility. PMID:34697550
Text Mining for Building Biomedical Networks Using Cancer as a Case Study. PMID:34680062
webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study. PMID:34669946
Urinary proteomics investigations into contrast-induced acute kidney injury. PMID:34669736
Drug repurposing improves disease targeting 11-fold and can be augmented by network module targeting, applied to COVID-19. PMID:34667255
Integrating heterogeneous data to facilitate COVID-19 drug repurposing. PMID:34666181
PopHumanVar: an interactive application for the functional characterization and prioritization of adaptive genomic variants in humans. PMID:34664660
Network Pharmacology-Based and Molecular Docking-Based Analysis of Suanzaoren Decoction for the Treatment of Parkinson's Disease with Sleep Disorder. PMID:34660782
Large Scale Identification of Osteosarcoma Pathogenic Genes by Multiple Extreme Learning Machine. PMID:34646831
Risk Prediction of Cardiovascular Events by Exploration of Molecular Data with Explainable Artificial Intelligence. PMID:34638627
Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants. PMID:34636724
TSMDA: Target and symptom-based computational model for miRNA-disease-association prediction. PMID:34631283
A meta-analysis of prognostic biomarkers in neonatal retinal hemorrhage. PMID:34623569
COVID-19 knowledge graph from semantic integration of biomedical literature and databases. PMID:34613368
SicknessMiner: a deep-learning-driven text-mining tool to abridge disease-disease associations. PMID:34607568
Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type and Shank2-Mutant Mice. PMID:34594187
COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19. PMID:34593915
COVIDium: a COVID-19 resource compendium. PMID:34585731
Idebenone-Activating Autophagic Degradation of α-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson's Disease: A Network Pharmacological Approach. PMID:34567221
Exploring the Molecular Mechanism of Liuwei Dihuang Pills for Treating Diabetic Nephropathy by Combined Network Pharmacology and Molecular Docking. PMID:34552655
Sex-dependent gene co-expression in the human body. PMID:34548535
Xiaoyu Xiezhuo Drink Protects against Ischemia-Reperfusion Acute Kidney Injury in Aged Mice through Inhibiting the TGF-β1/Smad3 and HIF1 Signaling Pathways. PMID:34545331
Potential mechanism of Ziyin Tongluo Formula in the treatment of postmenopausal osteoporosis: based on network pharmacology and ovariectomized rat model. PMID:34530875
Network Pharmacology-Based Analysis on the Potential Biological Mechanisms of Sinisan Against Non-Alcoholic Fatty Liver Disease. PMID:34512330
CancerMIRNome: an interactive analysis and visualization database for miRNome profiles of human cancer. PMID:34500460
Transcriptional progression during meiotic prophase I reveals sex-specific features and X chromosome dynamics in human fetal female germline. PMID:34499650
NOCICEPTRA: Gene and microRNA Signatures and Their Trajectories Characterizing Human iPSC-Derived Nociceptor Maturation. PMID:34486248
An Ovarian Cancer Susceptible Gene Prediction Method Based on Deep Learning Methods. PMID:34485310
A data-driven methodology towards evaluating the potential of drug repurposing hypotheses. PMID:34471499
A validated generally applicable approach using the systematic assessment of disease modules by GWAS reveals a multi-omic module strongly associated with risk factors in multiple sclerosis. PMID:34461822
Mnt Represses Epithelial Identity To Promote Epithelial-to-Mesenchymal Transition. PMID:34460331
Neonatal Exposure to BPA, BDE-99, and PCB Produces Persistent Changes in Hepatic Transcriptome Associated With Gut Dysbiosis in Adult Mouse Livers. PMID:34453844
Inference of an Integrative, Executable Network for Rheumatoid Arthritis Combining Data-Driven Machine Learning Approaches and a State-of-the-Art Mechanistic Disease Map. PMID:34442429
Biomolecule and Bioentity Interaction Databases in Systems Biology: A Comprehensive Review. PMID:34439912
Phosphoproteomics Identifies Significant Biomarkers Associated with the Proliferation and Metastasis of Prostate Cancer. PMID:34437425
A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke. PMID:34434246
Ameliorative Effects and Mechanism of Buyang Huanwu Decoction on Pulmonary Vascular Remodeling: Network and Experimental Analyses. PMID:34422208
Identification of Potential Bioactive Ingredients and Mechanisms of the Guanxin Suhe Pill on Angina Pectoris by Integrating Network Pharmacology and Molecular Docking. PMID:34422068
SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs. PMID:34413339
Prediction of Genetic Factors of Hyperthyroidism Based on Gene Interaction Network. PMID:34409035
Cox-sMBPLS: An Algorithm for Disease Survival Prediction and Multi-Omics Module Discovery Incorporating Cis-Regulatory Quantitative Effects. PMID:34408773
Network Pharmacology and Experimental Evidence: PI3K/AKT Signaling Pathway is Involved in the Antidepressive Roles of Chaihu Shugan San. PMID:34385814
Formononetin protects against ox-LDL-induced endothelial dysfunction by activating PPAR-γ signaling based on network pharmacology and experimental validation. PMID:34369277
Derivation and Molecular Characterization of a Morphological Subpopulation of Human iPSC Astrocytes Reveal a Potential Role in Schizophrenia and Clozapine Response. PMID:34357384
A Network Pharmacology Approach to Investigate the Mechanism of Erjing Prescription in Type 2 Diabetes. PMID:34349832
Mapping Autoantibodies in Children With Acute Rheumatic Fever. PMID:34335616
A Combined Network Pharmacology and Molecular Docking Approach to Investigate Candidate Active Components and Multitarget Mechanisms of Hemerocallis Flowers on Antidepressant Effect. PMID:34306154
A comprehensive investigation on liver regeneration: a meta-analysis and systems biology approach. PMID:34295986
X-chromosome influences on neuroanatomical variation in humans. PMID:34294918
PPI-MASS: An Interactive Web Server to Identify Protein-Protein Interactions From Mass Spectrometry-Based Proteomics Data. PMID:34277709
Role of Plant-Derived Natural Compounds in Experimental Autoimmune Encephalomyelitis: A Review of the Treatment Potential and Development Strategy. PMID:34262447
DNA methylation analysis reveals epimutation hotspots in patients with dilated cardiomyopathy-associated laminopathies. PMID:34246298
An integrative network-based approach for drug target indication expansion. PMID:34242265
Integrative Analysis of Incongruous Cancer Genomics and Proteomics Datasets. PMID:34236668
ORA , FCS , and PT Strategies in Functional Enrichment Analysis. PMID:34236661
RENET2: high-performance full-text gene-disease relation extraction with iterative training data expansion. PMID:34235433
REVA as A Well-curated Database for Human Expression-modulating Variants. PMID:34224878
A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine. PMID:34221858
Is there a relationship between psoriasis and hepatitis C? A meta-analysis and bioinformatics investigation. PMID:34215260
Translational Proteomics Analysis of Anthracycline-Induced Cardiotoxicity From Cardiac Microtissues to Human Heart Biopsies. PMID:34211507
Gypenosides Alleviate Cone Cell Death in a Zebrafish Model of Retinitis Pigmentosa. PMID:34209942
Toward a Coronavirus Knowledge Graph. PMID:34209818
Leveraging network analysis to evaluate biomedical named entity recognition tools. PMID:34188248
Mapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment. PMID:34184731
Pan-Cancer Metastasis Prediction Based on Graph Deep Learning Method. PMID:34179004
Assembling Disease Networks From Causal Interaction Resources. PMID:34178043
Gene Dosage- and Age-Dependent Differential Transcriptomic Changes in the Prefrontal Cortex of Shank2-Mutant Mice. PMID:34177464
Therapeutic effects of Sheng Xue Fang in a cyclophosphamide-induced anaemia mouse model. PMID:34176428
Sulforaphane improves mitochondrial metabolism in fibroblasts from patients with fragile X-associated tremor and ataxia syndrome. PMID:34153466
Construction and Analysis of the Dysregulated ceRNA Network and Identification of Risk Long Noncoding RNAs in Breast Cancer. PMID:34149805
The DisGeNET cytoscape app: Exploring and visualizing disease genomics data. PMID:34136095
Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology. PMID:34135558
Genome-wide discovery of hidden genes mediating known drug-disease association using KDDANet. PMID:34131148
DGLinker: flexible knowledge-graph prediction of disease-gene associations. PMID:34125897
Exploring polyps to colon carcinoma voyage: can blocking the crossroad halt the sequence? PMID:34115239
A framework for automated gene selection in genomic applications. PMID:34113001
Genomic insights into body size evolution in Carnivora support Peto's paradox. PMID:34107880
The association between hypertension and nonalcoholic fatty liver disease (NAFLD): literature evidence and systems biology analysis. PMID:34096467
Integrating Spatial Transcriptomics and Single-Cell RNA-seq Reveals the Gene Expression Profling of the Human Embryonic Liver. PMID:34095116
Cruxome: a powerful tool for annotating, interpreting and reporting genetic variants. PMID:34082700
GATCDA: Predicting circRNA-Disease Associations Based on Graph Attention Network. PMID:34070678
Predicting COVID-19-Comorbidity Pathway Crosstalk-Based Targets and Drugs: Towards Personalized COVID-19 Management. PMID:34067609
Cascading from SARS-CoV-2 to Parkinson's Disease through Protein-Protein Interactions. PMID:34066091
Multiple Reaction Monitoring-Based Targeted Assays for the Validation of Protein Biomarkers in Brain Tumors. PMID:34055594
Systems Pharmacology and In Silico Docking Analysis Uncover Association of CA2, PPARG, RXRA, and VDR with the Mechanisms Underlying the Shi Zhen Tea Formula Effect on Eczema. PMID:34055023
Progesterone Dampens Immune Responses in In Vitro Activated CD4+ T Cells and Affects Genes Associated With Autoimmune Diseases That Improve During Pregnancy. PMID:34054852
Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma. PMID:34050187
A Study to Decipher the Potential Effects of Butylphthalide against Central Nervous System Diseases Based on Network Pharmacology and Molecular Docking Integration Strategy. PMID:34035826
Mapping OMIM Disease-Related Variations on Protein Domains Reveals an Association Among Variation Type, Pfam Models, and Disease Classes. PMID:34026820
Integrated Pharmacological Analysis on the Mechanism of Fuyou Formula in Treating Precocious Puberty. PMID:34025416
Host pharmacogenetic factors that may affect liver neoplasm incidence upon using direct-acting antivirals for treating hepatitis C infection. PMID:34013078
Risk of Non-Alcoholic Fatty Liver Disease in Xanthelasma Palpebrarum. PMID:34012287
Characterization and comparison of gene-centered human interactomes. PMID:34010955
Investigation of the Mechanism of Traditional Chinese Medicines in Angiogenesis through Network Pharmacology and Data Mining. PMID:34007289
Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis. PMID:34004362
Integrative biochemical, proteomics and metabolomics cerebrospinal fluid biomarkers predict clinical conversion to multiple sclerosis. PMID:33997784
Network Pharmacology-Based Investigation of the Therapeutic Mechanisms of Action of Danning Tablets in Nonalcoholic Fatty Liver Disease. PMID:33995543
Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions. PMID:33988505
IDSM ChemWebRDF: SPARQLing small-molecule datasets. PMID:33980298
Deciphering Pharmacological Mechanism of Buyang Huanwu Decoction for Spinal Cord Injury by Network Pharmacology Approach. PMID:33976706
Melatonin: Multi-Target Mechanism Against Diminished Ovarian Reserve Based on Network Pharmacology. PMID:33959095
A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression. PMID:33937393
Disparities in COVID-19 severities and casualties across ethnic groups around the globe and patterns of ACE2 and PIR variants. PMID:33933634
MicroRNAs in the aqueous humor of patients with different types of glaucoma. PMID:33929592
Integrated analysis and identification of nine-gene signature associated to oral squamous cell carcinoma pathogenesis. PMID:33928003
Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness. PMID:33924911
Comorbidities and Susceptibility to COVID-19: A Generalized Gene Set Data Mining Approach. PMID:33924631
Proteomic and Bioinformatic Investigation of Altered Pathways in Neuroglobin-Deficient Breast Cancer Cells. PMID:33924212
Shared Neurodevelopmental Perturbations Can Lead to Intellectual Disability in Individuals with Distinct Rare Chromosome Duplications. PMID:33922640
Study on the Sleep-Improvement Effects of Hemerocallis citrina Baroni in Drosophila melanogaster and Targeted Screening to Identify Its Active Components and Mechanism. PMID:33920660
Key Disease Mechanisms Linked to Alzheimer's Disease in the Entorhinal Cortex. PMID:33920138
A Network Medicine Approach for Drug Repurposing in Duchenne Muscular Dystrophy. PMID:33918694
Human Endogenous Retroviruses in Glioblastoma Multiforme. PMID:33917421
Genetic etiologies associated with infantile hydrocephalus in a Chinese infantile cohort. PMID:33914258
The microRNA analysis portal is a next-generation tool for exploring and analyzing miRNA-focused data in the literature. PMID:33903708
Familial Psychosis Associated With a Missense Mutation at MACF1 Gene Combined With the Rare Duplications DUP3p26.3 and DUP16q23.3, Affecting the CNTN6 and CDH13 Genes. PMID:33897758
Finding associations in a heterogeneous setting: statistical test for aberration enrichment. PMID:33892787
MultiVERSE: a multiplex and multiplex-heterogeneous network embedding approach. PMID:33888761
Exploring the Pharmacological Mechanism of Duhuo Jisheng Decoction in Treating Osteoporosis Based on Network Pharmacology. PMID:33880122
An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies. PMID:33875015
The Use of Traditional Chinese Medicine in Relieving EGFR-TKI-Associated Diarrhea Based on Network Pharmacology and Data Mining. PMID:33868436
A Survey of Compound Heterozygous Variants in Pediatric Cancers and Structural Birth Defects. PMID:33828584
miRSM: an R package to infer and analyse miRNA sponge modules in heterogeneous data. PMID:33822666
Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins. PMID:33820928
CogNet: classification of gene expression data based on ranked active-subnetwork-oriented KEGG pathway enrichment analysis. PMID:33816987
Search, access, and explore life science nanopublications on the Web. PMID:33816986
ScanBious: Survey for Obesity Genes Using PubMed Abstracts and DisGeNET. PMID:33805313
The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells. PMID:33799834
Comorbidity between Alzheimer's disease and major depression: a behavioural and transcriptomic characterization study in mice. PMID:33795014
Network based multifactorial modelling of miRNA-target interactions. PMID:33777541
The Diabetes Syndrome - A Collection of Conditions with Common, Interrelated Pathophysiologic Mechanisms. PMID:33776471
Dysregulation of MicroRNAs and PIWI-Interacting RNAs in a Caenorhabditis elegans Parkinson's Disease Model Overexpressing Human α-Synuclein and Influence of tdp-1. PMID:33762903
A small molecule compound berberine as an orally active therapeutic candidate against COVID-19 and SARS: A computational and mechanistic study. PMID:33749932
Leveraging the cell lineage to predict cell-type specificity of regulatory variation from bulk genomics. PMID:33734353
Towards realizing the vision of precision medicine: AI based prediction of clinical drug response. PMID:33734308
Transcriptional profiling reveals the transcription factor networks regulating the survival of striatal neurons. PMID:33712552
A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes' interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19. PMID:33684134
Knowledge-Guided "Community Network" Analysis Reveals the Functional Modules and Candidate Targets in Non-Small-Cell Lung Cancer. PMID:33669233
The Implications of ncRNAs in the Development of Human Diseases. PMID:33668203
A chromosome-level genome of Astyanax mexicanus surface fish for comparing population-specific genetic differences contributing to trait evolution. PMID:33664263
Benchmarking network-based gene prioritization methods for cerebral small vessel disease. PMID:33634312
Discovering pathways in benign prostate hyperplasia: A functional genomics pilot study. PMID:33603850
Predicting Biomedical Interactions With Higher-Order Graph Convolutional Networks. PMID:33587705
The CLAIRE COVID-19 initiative: approach, experiences and recommendations. PMID:33584129
Guidelines for biomarker discovery in endometrium: correcting for menstrual cycle bias reveals new genes associated with uterine disorders. PMID:33576824
Membrane Interactome of a Recombinant Fragment of Human Surfactant Protein D Reveals GRP78 as a Novel Binding Partner in PC3, a Metastatic Prostate Cancer Cell Line. PMID:33542717
The Functional Impact of Alternative Splicing on the Survival Prognosis of Triple-Negative Breast Cancer. PMID:33519909
Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology. PMID:33517789
Evolutionary conservation and divergence of the human brain transcriptome. PMID:33514394
Network Pharmacology-Based Analysis on the Mechanism of Action of Ephedrae Herba-Cinnamomi Ramulus Couplet Medicines in the Treatment for Psoriasis. PMID:33513128
Similarities and dissimilarities between psychiatric cluster disorders. PMID:33504954
Network Pharmacology Analysis of the Therapeutic Mechanisms Underlying Beimu-Gualou Formula Activity against Bronchiectasis with In Silico Molecular Docking Validation. PMID:33488758
Study of the active ingredients and mechanism of Sparganii rhizoma in gastric cancer based on HPLC-Q-TOF-MS/MS and network pharmacology. PMID:33479376
Large-scale regulatory and signaling network assembly through linked open data. PMID:33459761
Pharmacological Network Reveals the Active Mechanism of Qi-Replenishing, Spleen-Strengthening, Phlegm-Dispelling, and Blood-Nourishing Fufang on Coronary Heart Disease. PMID:33456482
Establishment and application of information resource of mutant mice in RIKEN BioResource Research Center. PMID:33455583
Exploring the treatment of COVID-19 with Yinqiao powder based on network pharmacology. PMID:33452734
Internetwork connectivity of molecular networks across species of life. PMID:33441907
Artificial Intelligence in Drug Discovery: A Comprehensive Review of Data-driven and Machine Learning Approaches. PMID:33437151
Systems Pharmacology-Based Identification of Mechanisms of Action of Bolbostemma paniculatum for the Treatment of Hepatocellular Carcinoma. PMID:33436534
Revealing mechanism of Caulis Sargentodoxae for the treatment of ulcerative colitis based on network pharmacology approach. PMID:33432986
Exploring the Antitumor Mechanisms of Zingiberis Rhizoma Combined with Coptidis Rhizoma Using a Network Pharmacology Approach. PMID:33426081
Identify Molecular Mechanisms of Jiangzhi Decoction on Nonalcoholic Fatty Liver Disease by Network Pharmacology Analysis and Experimental Validation. PMID:33415161
Prediction of hub genes of Alzheimer's disease using a protein interaction network and functional enrichment analysis. PMID:33412755
Uncovering the mechanism of Ge-Gen-Qin-Lian decoction for treating ulcerative colitis based on network pharmacology and molecular docking verification. PMID:33409535
MiBiOmics: an interactive web application for multi-omics data exploration and integration. PMID:33407076
The status of causality in biological databases: data resources and data retrieval possibilities to support logical modeling. PMID:33378765
Unraveling Targetable Systemic and Cell-Type-Specific Molecular Phenotypes of Alzheimer's and Parkinson's Brains With Digital Cytometry. PMID:33362460
Oncology and Pharmacogenomics Insights in Polycystic Ovary Syndrome: An Integrative Analysis. PMID:33329391
Tensor-Decomposition-Based Unsupervised Feature Extraction Applied to Prostate Cancer Multiomics Data. PMID:33322492
Mechanism of Action of Bu-Fei-Yi-Shen Formula in Treating Chronic Obstructive Pulmonary Disease Based on Network Pharmacology Analysis and Molecular Docking Validation. PMID:33313323
Cellular correlates of cortical thinning throughout the lifespan. PMID:33311571
Exploring the Possible Mechanism and Drug Targets of Huang-Qi-Gui-Zhi-Wu-Wu Decoction for the Treatment of Chemotherapy-Induced Peripheral Neuropathy on Network Pharmacology. PMID:33299447
Mining of gene modules and identification of key genes in head and neck squamous cell carcinoma based on gene co-expression network analysis. PMID:33285674
Study on Medication Rules of Traditional Chinese Medicine against Antineoplastic Drug-Induced Cardiotoxicity Based on Network Pharmacology and Data Mining. PMID:33281914
CovMulNet19, Integrating Proteins, Diseases, Drugs, and Symptoms: A Network Medicine Approach to COVID-19. PMID:33274348
SkipGNN: predicting molecular interactions with skip-graph networks. PMID:33273494
HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine. PMID:33264402
Drug2ways: Reasoning over causal paths in biological networks for drug discovery. PMID:33264280
Natural variation of the cardiac transcriptome in humans. PMID:33258390
What Can Machine Learning Approaches in Genomics Tell Us about the Molecular Basis of Amyotrophic Lateral Sclerosis? PMID:33256133
UniProt: the universal protein knowledgebase in 2021. PMID:33237286
Investigating the Multitarget Mechanism of Traditional Chinese Medicine Prescription for Cancer-Related Pain by Using Network Pharmacology and Molecular Docking Approach. PMID:33224254
Moving targets in drug discovery. PMID:33214619
Open Targets Platform: supporting systematic drug-target identification and prioritisation. PMID:33196847
Systematic Analysis of Competing Endogenous RNA Networks in Diffuse Large B-Cell Lymphoma and Hodgkin's Lymphoma. PMID:33193722
Integrating Pharmacology and Gut Microbiota Analysis to Explore the Mechanism of Citri Reticulatae Pericarpium Against Reserpine-Induced Spleen Deficiency in Rats. PMID:33192528
Bioinformatic analysis of SMN1-ACE/ACE2 interactions hinted at a potential protective effect of spinal muscular atrophy against COVID-19-induced lung injury. PMID:33190150
Virtual screening and network pharmacology-based synergistic mechanism identification of multiple components contained in Guanxin V against coronary artery disease. PMID:33187508
Revealing the Pharmacological Mechanism of Acorus tatarinowii in the Treatment of Ischemic Stroke Based on Network Pharmacology. PMID:33178313
ASDmiR: A Stepwise Method to Uncover miRNA Regulation Related to Autism Spectrum Disorder. PMID:33173536
Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy. PMID:33173052
Landscape of active enhancers developed de novo in cirrhosis and conserved in hepatocellular carcinoma. PMID:33163263
TCRD and Pharos 2021: mining the human proteome for disease biology. PMID:33156327
Tumor cell endogenous HIF-1α activity induces aberrant angiogenesis and interacts with TRAF6 pathway required for colorectal cancer development. PMID:33142239
Systematic analysis to identify transcriptome-wide dysregulation of Alzheimer's disease in genes and isoforms. PMID:33140241
Ensembl 2021. PMID:33137190
Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19. PMID:33131530
Upregulation of miR-9 and miR-193b over human Th17 cell differentiation. PMID:33128433
Molecular Targets and Pathways Contributing to the Effects of Wenxin Keli on Atrial Fibrillation Based on a Network Pharmacology Approach. PMID:33123211
Protein-driven mechanism of multiorgan damage in COVID-19. PMID:33103107
System biological investigations of hydroxychloroquine and azithromycin targets and their implications in QT interval prolongation. PMID:33098839
VARAdb: a comprehensive variation annotation database for human. PMID:33095866
Understand variability of COVID-19 through population and tissue variations in expression of SARS-CoV-2 host genes. PMID:33072849
STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology. PMID:33046834
Protein ontology on the semantic web for knowledge discovery. PMID:33046717
Uncovering the protective mechanism of Taohong Siwu decoction against diabetic retinopathy via HIF-1 signaling pathway based on network analysis and experimental validation. PMID:33023593
RMVar: an updated database of functional variants involved in RNA modifications. PMID:33021671
Coordinated analysis of exon and intron data reveals novel differential gene expression changes. PMID:32973253
SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol. PMID:32957927
Data-Driven Modeling of Knowledge Assemblies in Understanding Comorbidity Between Type 2 Diabetes Mellitus and Alzheimer's Disease. PMID:32925069
In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age. PMID:32898168
PCOSKBR2: a database of genes, diseases, pathways, and networks associated with polycystic ovary syndrome. PMID:32895427
High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients. PMID:32873298
Fractional diffusion on the human proteome as an alternative to the multi-organ damage of SARS-CoV-2. PMID:32872802
CaNDis: a web server for investigation of causal relationships between diseases, drugs and drug targets. PMID:32871004
Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders. PMID:32857118
Neurological manifestations of COVID-19: available evidences and a new paradigm. PMID:32839951
NetCore: a network propagation approach using node coreness. PMID:32735660
Merging microarray studies to identify a common gene expression signature to several structural heart diseases. PMID:32670412
Core regulatory circuitries in defining cancer cell identity across the malignant spectrum. PMID:32634370
Data and Text Mining Help Identify Key Proteins Involved in the Molecular Mechanisms Shared by SARS-CoV-2 and HIV-1. PMID:32604797
A Knowledge-Based Machine Learning Approach to Gene Prioritisation in Amyotrophic Lateral Sclerosis. PMID:32575372
An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer. PMID:32455963
COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms. PMID:32371892
The Sodium Channel B4-Subunits are Dysregulated in Temporal Lobe Epilepsy Drug-Resistant Patients. PMID:32331418
Circulating RNA Transcriptome of Pregnant Women with TSH Just Above the Trimester-Specific Reference and its Correlation with the Hypertensive Phenotype. PMID:32296081
The 27th annual Nucleic Acids Research database issue and molecular biology database collection. PMID:31906604
DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes PubMed citations: 341.

341 articles citing: DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes

Network Pharmacology-Based Strategy to Investigate the Mechanisms of Cibotium barometz in Treating Osteoarthritis. PMID:35873632
Identification of Molecular Targets and Potential Mechanisms of Yinchen Wuling San Against Head and Neck Squamous Cell Carcinoma by Network Pharmacology and Molecular Docking. PMID:35873484
Analysis of Lymphoma-Related Genes with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes Enrichment. PMID:35795312
Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis. PMID:35792766
A Computational Data Mining Strategy to Identify the Common Genetic Markers of Temporomandibular Joint Disorders and Osteoarthritis. PMID:35707787
Molecular Targets and Mechanisms of Hedyotis diffusa-Scutellaria barbata Herb Pair for the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking. PMID:35707465
Network approaches for modeling the effect of drugs and diseases. PMID:35704883
How can natural language processing help model informed drug development?: a review. PMID:35702625
Transcriptomal Insights of Heart Failure from Normality to Recovery. PMID:35625658
GenePlexus: a web-server for gene discovery using network-based machine learning. PMID:35580053
Exploring Molecular Mechanisms of Aloe barbadmsis Miller on Diphenoxylate-Induced Constipation in Mice. PMID:35571728
Network pharmacology combined with molecular docking to explore the potential mechanisms for the antioxidant activity of Rheum tanguticum seeds. PMID:35505340
A game changer for bipolar disorder diagnosis using RNA editing-based biomarkers. PMID:35504874
The Mechanism of Dendrobium officinale as a Treatment for Hyperlipidemia Based on Network Pharmacology and Experimental Validation. PMID:35502176
Molecular Evolutionary Rate Predicts Intraspecific Genetic Polymorphism and Species-Specific Selection. PMID:35456514
Transcriptomic Analysis of Fumarate Compounds Identifies Unique Effects of Isosorbide Di-(Methyl Fumarate) on NRF2, NF-kappaB and IRF1 Pathway Genes. PMID:35455458
Identification of potential pathogenic genes for severe aplastic anemia by whole-exome sequencing. PMID:35435273
Mouse models of immune dysfunction: their neuroanatomical differences reflect their anxiety-behavioural phenotype. PMID:35422470
Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers. PMID:35410466
B4GALT5 high expression associated with poor prognosis of hepatocellular carcinoma. PMID:35410157
Genetics Matters: Voyaging from the Past into the Future of Humanity and Sustainability. PMID:35409335
Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration. PMID:35370556
INPUT: An intelligent network pharmacology platform unique for traditional Chinese medicine. PMID:35356545
Protein interaction networks provide insight into fetal origins of chronic obstructive pulmonary disease. PMID:35331221
Screening the Significant Hub Genes by Comparing Tumor Cells, Normoxic and Hypoxic Glioblastoma Stem-like Cell Lines Using Co-Expression Analysis in Glioblastoma. PMID:35328072
Analysis of Genes Associated with Both Neural Tube Defects and Neuroectodermal Tumors. PMID:35318299
Cell cycle arrest is an important mechanism of action of compound Kushen injection in the prevention of colorectal cancer. PMID:35288618
Systematic understanding of anti-tumor mechanisms of Tamarixetin through network and experimental analyses. PMID:35273218
Mechanisms of Vitamin C Regulating Immune and Inflammation Associated with Neonatal Hypoxic-Ischemic Encephalopathy Based on Network Pharmacology and Molecular Simulation Technology. PMID:35198034
Pseudoautosomal Region 1 Overdosage Affects the Global Transcriptome in iPSCs From Patients With Klinefelter Syndrome and High-Grade X Chromosome Aneuploidies. PMID:35186953
Integrative OMICS Data-Driven Procedure Using a Derivatized Meta-Analysis Approach. PMID:35186042
Human Immune System Diseasome Networks and Female Oviductal Microenvironment: New Horizons to be Discovered. PMID:35154249
Prioritization of putatively detrimental variants in euploid miscarriages. PMID:35132093
Detecting gene-gene interactions from GWAS using diffusion kernel principal components. PMID:35105309
A New Prospect for the Treatment of Nephrotic Syndrome Based on Network Pharmacology Analysis. PMID:35098155
Smell Detection Agent Optimisation Framework and Systems Biology Approach to Detect Dys-Regulated Subnetwork in Cancer Data. PMID:35053185
Computer-Aided Drug Design (CADD) to De-Orphanize Marine Molecules: Finding Potential Therapeutic Agents for Neurodegenerative and Cardiovascular Diseases. PMID:35049908
Pharmacological Mechanisms of Tinglizi against Chronic Heart Failure Determined by Network Pharmacology and Molecular Docking. PMID:35035498
Re-wiring and gene expression changes of AC025034.1 and ATP2B1 play complex roles in early-to-late breast cancer progression. PMID:35031021
Network pharmacology reveals the potential mechanism of Baiying Qinghou decoction in treating laryngeal squamous cell carcinoma. PMID:34986125
An integrated brain-specific network identifies genes associated with neuropathologic and clinical traits of Alzheimer's disease. PMID:34953465
A Random Walk-Based Method to Identify Candidate Genes Associated With Lymphoma. PMID:34899868
Graph Embedding Based Novel Gene Discovery Associated With Diabetes Mellitus. PMID:34899863
(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells. PMID:34884975
Disentangling genetic feature selection and aggregation in transcriptome-wide association studies. PMID:34849857
Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge. PMID:34834924
Using Comorbidity Pattern Analysis to Detect Reliable Methylated Genes in Colorectal Cancer Verified by Stool DNA Test. PMID:34680934
Text Mining for Building Biomedical Networks Using Cancer as a Case Study. PMID:34680062
Elevated level of the soluble receptor for advanced glycation end-products involved in sarcopenia: an observational study. PMID:34620111
A Network Pharmacology Study on the Molecular Mechanism of Protocatechualdehyde in the Treatment of Diabetic Cataract. PMID:34594100
Prioritizing Susceptible Genes for Thyroid Cancer Based on Gene Interaction Network. PMID:34497810
Reconstruction of the Cytokine Signaling in Lysosomal Storage Diseases by Literature Mining and Network Analysis. PMID:34490253
Drug repurposing for COVID-19 using computational screening: Is Fostamatinib/R406 a potential candidate? PMID:34455072
Promising Anticancer Activity of [Bis(1,8-quinolato)palladium (II)] Alone and in Combination. PMID:34445176
Comprior: facilitating the implementation and automated benchmarking of prior knowledge-based feature selection approaches on gene expression data sets. PMID:34384353
MicroRNA-216b targets HK2 to potentiate autophagy and apoptosis of breast cancer cells via the mTOR signaling pathway. PMID:34345220
The Potential Effect of Rhizoma coptidis on Polycystic Ovary Syndrome Based on Network Pharmacology and Molecular Docking. PMID:34306142
A comprehensive investigation on liver regeneration: a meta-analysis and systems biology approach. PMID:34295986
The conserved ASTN2/BRINP1 locus at 9q33.1-33.2 is associated with major psychiatric disorders in a large pedigree from Southern Spain. PMID:34267256
Identification of viral-mediated pathogenic mechanisms in neurodegenerative diseases using network-based approaches. PMID:34237135
Predicting miRNA-Disease Association Based on Modularity Preserving Heterogeneous Network Embedding. PMID:34178973
Genome-wide discovery of hidden genes mediating known drug-disease association using KDDANet. PMID:34131148
Identification and Tissue-Specific Characterization of Novel SHOX-Regulated Genes in Zebrafish Highlights SOX Family Members Among Other Genes. PMID:34122528
A framework for automated gene selection in genomic applications. PMID:34113001
Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma. PMID:34101353
High glucose induced c-Met activation promotes aggressive phenotype and regulates expression of glucose metabolism genes in HCC cells. PMID:34059694
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis. PMID:34031600
A Combined Phytochemistry and Network Pharmacology Approach to Reveal Potential Anti-NSCLC Effective Substances and Mechanisms in Marsdenia tenacissima (Roxb.) Moon (Stem). PMID:33994999
Prediction of Synergistic Drug Combinations for Prostate Cancer by Transcriptomic and Network Characteristics. PMID:33986671
IDSM ChemWebRDF: SPARQLing small-molecule datasets. PMID:33980298
The Relationship Between Menopause and Metabolic Syndrome: Experimental and Bioinformatics Analysis. PMID:33973091
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. PMID:33972514
A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression. PMID:33937393
MicroRNAs in the aqueous humor of patients with different types of glaucoma. PMID:33929592
Study on the Sleep-Improvement Effects of Hemerocallis citrina Baroni in Drosophila melanogaster and Targeted Screening to Identify Its Active Components and Mechanism. PMID:33920660
Identification of potential candidate genes for lip and oral cavity cancer using network analysis. PMID:33840168
Application and evaluation of knowledge graph embeddings in biomedical data. PMID:33816992
Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis. PMID:33781493
A Network Pharmacology to Explore the Mechanism of Calculus Bovis in the Treatment of Ischemic Stroke. PMID:33778069
Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution. PMID:33731941
Integration of summary data from GWAS and eQTL studies identified novel risk genes for coronary artery disease. PMID:33725943
Decoding the Mechanism of Huanglian Jiedu Decoction in Treating Pneumonia Based on Network Pharmacology and Molecular Docking. PMID:33681222
System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of GanDouLing for Wilson's Disease. PMID:33564316
Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology. PMID:33517789
Contextualized Protein-Protein Interactions. PMID:33511361
Similarities and dissimilarities between psychiatric cluster disorders. PMID:33504954
Internetwork connectivity of molecular networks across species of life. PMID:33441907
Artificial Intelligence in Drug Discovery: A Comprehensive Review of Data-driven and Machine Learning Approaches. PMID:33437151
MicroPhenoDB Associates Metagenomic Data with Pathogenic Microbes, Microbial Core Genes, and Human Disease Phenotypes. PMID:33418085
Pathway Maps of Orphan and Complex Diseases Using an Integrative Computational Approach. PMID:33376724
Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway. PMID:33344651
Predicting Metabolite-Disease Associations Based on Spy Strategy and ABC Algorithm. PMID:33344506
Systems biology in cardiovascular disease: a multiomics approach. PMID:33340009
PDmethDB: A curated Parkinson's disease associated methylation information database. PMID:33304468
Genetic Polymorphism of ADORA2A Is Associated With the Risk of Epilepsy and Predisposition to Neurologic Comorbidity in Chinese Southern Children. PMID:33262686
Endocrine disrupting chemicals and COVID-19 relationships: A computational systems biology approach. PMID:33223326
Revealing the Pharmacological Mechanism of Acorus tatarinowii in the Treatment of Ischemic Stroke Based on Network Pharmacology. PMID:33178313
Discover novel disease-associated genes based on regulatory networks of long-range chromatin interactions. PMID:33096239
Comprehensive Analysis of RNA-Seq Gene Expression Profiling of Brain Transcriptomes Reveals Novel Genes, Regulators, and Pathways in Autism Spectrum Disorder. PMID:33080834
Free Wanderer Powder regulates AMPA receptor homeostasis in chronic restraint stress-induced rat model of depression with liver-depression and spleen-deficiency syndrome. PMID:33052137
Guanxinshutong Alleviates Atherosclerosis by Suppressing Oxidative Stress and Proinflammation in ApoE-/- Mice. PMID:33014098
RepCOOL: computational drug repositioning via integrating heterogeneous biological networks. PMID:33008415
CSVS, a crowdsourcing database of the Spanish population genetic variability. PMID:32990755
A Network Pharmacological Approach to Investigate the Mechanism of Action of Active Ingredients of Epimedii Herba and Their Potential Targets in Treatment of Alzheimer's Disease. PMID:32980851
Cilia interactome with predicted protein-protein interactions reveals connections to Alzheimer's disease, aging and other neuropsychiatric processes. PMID:32973177
Integrative genomics analysis of various omics data and networks identify risk genes and variants vulnerable to childhood-onset asthma. PMID:32867763
Non-BRAF Mutant Melanoma: Molecular Features and Therapeutical Implications. PMID:32850962
Network-based modeling of drug effects on disease module in systemic sclerosis. PMID:32770109
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases. PMID:32707033
Identification of early stage recurrence endometrial cancer biomarkers using bioinformatics tools. PMID:32705231
Endocrine disrupting chemicals and COVID-19 relationships: a computational systems biology approach. PMID:32699854
Investigation on the Mechanism of Qubi Formula in Treating Psoriasis Based on Network Pharmacology. PMID:32655662
A bioinformatics investigation into the pharmacological mechanisms of javanica oil emulsion injection in non-small cell lung cancer based on network pharmacology methodologies. PMID:32503508
The common pathophysiologic threads between Asian Indian diabetic's 'Thin Fat Phenotype' and partial lipodystrophy: the peripheral adipose tissue transcriptomic evidences. PMID:32491965
Establishment of a CALU, AURKA, and MCM2 gene panel for discrimination of metastasis from primary colon and lung cancers. PMID:32469983
Predicting miRNA-based disease-disease relationships through network diffusion on multi-omics biological data. PMID:32457435
An Analysis of the Anti-Neuropathic Effects of Qi She Pill Based on Network Pharmacology. PMID:32454869
Post-translational Modification Crosstalk and Hotspots in Sirtuin Interactors Implicated in Cardiovascular Diseases. PMID:32425973
Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study. PMID:32393985
Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases. PMID:32358504
BioHackathon 2015: Semantics of data for life sciences and reproducible research. PMID:32308977
Integrated querying and version control of context-specific biological networks. PMID:32294194
Investigation of cardiovascular protective effect of Shenmai injection by network pharmacology and pharmacological evaluation. PMID:32293408
Ephrin-B1 Is a Novel Biomarker of Bladder Cancer Aggressiveness. Studies in Murine Models and in Human Samples. PMID:32292715
Network Structure Analysis Identifying Key Genes of Autism and Its Mechanism. PMID:32273901
An Integrated Pharmacology-Based Analysis for Antidepressant Mechanism of Chinese Herbal Formula Xiao-Yao-San. PMID:32256358
CLING: Candidate Cancer-Related lncRNA Prioritization via Integrating Multiple Biological Networks. PMID:32211391
Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria. PMID:32197664
Network Pharmacology Identifies the Mechanisms of Action of TaohongSiwu Decoction Against Essential Hypertension. PMID:32187175
Development and validation of a lipogenic genes panel for diagnosis and recurrence of colorectal cancer. PMID:32155177
The influence of rare variants in circulating metabolic biomarkers. PMID:32150548
Supervised learning is an accurate method for network-based gene classification. PMID:32129827
A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. PMID:32109415
Discovery of inflammatory bowel disease-associated miRNAs using a novel bipartite clustering approach. PMID:32093721
Loss of phosphatase activity in PTEN (phosphatase and tensin homolog deleted on chromosome ten) results in endometrial carcinoma in humans: An in-silico study. PMID:32042934
Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome. PMID:32041952
Gene Prioritization through Consensus Strategy, Enrichment Methodologies Analysis, and Networking for Osteosarcoma Pathogenesis. PMID:32033398
Based on network pharmacology to explore the molecular mechanisms of astragalus membranaceus for treating T2 diabetes mellitus. PMID:31930034
A Network-Based Method for Mechanistic Investigation and Neuroprotective Effect on Post-treatment of Senkyunolid-H Against Cerebral Ischemic Stroke in Mouse. PMID:31920923
Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer. PMID:31885751
N-Terminal Truncated Myb with New Transcriptional Activity Produced Through Use of an Alternative MYB Promoter in Salivary Gland Adenoid Cystic Carcinoma. PMID:31877778
On the hunt for the alternate host of Hemileia vastatrix. PMID:31871671
Benchmarking network algorithms for contextualizing genes of interest. PMID:31860671
The human DEPhOsphorylation Database DEPOD: 2019 update. PMID:31836896
Identification of common genetic markers of paroxysmal neurological disorders using a network analysis approach. PMID:31808001
Multivariable regulation of gene expression plasticity in metazoans. PMID:31795914
Using Network Pharmacology to Explore Potential Treatment Mechanism for Coronary Heart Disease Using Chuanxiong and Jiangxiang Essential Oils in Jingzhi Guanxin Prescriptions. PMID:31772600
The DisGeNET knowledge platform for disease genomics: 2019 update. PMID:31680165
An integrated epigenome and transcriptome analysis identifies PAX2 as a master regulator of drug resistance in high grade pancreatic ductal adenocarcinoma. PMID:31622355
Investigating the Multi-Target Pharmacological Mechanism of Hedyotis diffusa Willd Acting on Prostate Cancer: A Network Pharmacology Approach. PMID:31600936
Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach. PMID:31530902
A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. PMID:31494632
Model annotation and discovery with the Physiome Model Repository. PMID:31492098
Potentially repurposable drugs for schizophrenia identified from its interactome. PMID:31481665
A Radiogenomic Approach for Decoding Molecular Mechanisms Underlying Tumor Progression in Prostate Cancer. PMID:31480766
Astrocytes are direct cellular targets of lithium treatment: novel roles for lysyl oxidase and peroxisome-proliferator activated receptor-γ as astroglial targets of lithium. PMID:31477687
GATA1 gene silencing inhibits invasion, proliferation and migration of cholangiocarcinoma stem cells via disrupting the PI3K/AKT pathway. PMID:31456644
HPO-Shuffle: an associated gene prioritization strategy and its application in drug repurposing for the treatment of canine epilepsy. PMID:31427480
Evolutionary history of disease-susceptibility loci identified in longitudinal exome-wide association studies. PMID:31402603
Discovery of stroke-related blood biomarkers from gene expression network models. PMID:31391037
Avian Binocularity and Adaptation to Nocturnal Environments: Genomic Insights from a Highly Derived Visual Phenotype. PMID:31386143
Identification of Prognostic Biomarkers and Drugs Targeting Them in Colon Adenocarcinoma: A Bioinformatic Analysis. PMID:31370719
RITAN: rapid integration of term annotation and network resources. PMID:31355053
Integrating biomedical research and electronic health records to create knowledge-based biologically meaningful machine-readable embeddings. PMID:31292438
Prioritizing target-disease associations with novel safety and efficacy scoring methods. PMID:31285471
MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women. PMID:31211819
Identify the Key Active Ingredients and Pharmacological Mechanisms of Compound XiongShao Capsule in Treating Diabetic Peripheral Neuropathy by Network Pharmacology Approach. PMID:31210774
Systems Chemical Genetics-Based Drug Discovery: Prioritizing Agents Targeting Multiple/Reliable Disease-Associated Genes as Drug Candidates. PMID:31191604
Downregulated LRRK2 gene expression inhibits proliferation and migration while promoting the apoptosis of thyroid cancer cells by inhibiting activation of the JNK signaling pathway. PMID:31180559
Identifying Clinical Terms in Medical Text Using Ontology-Guided Machine Learning. PMID:31094361
OsteoporosAtlas: a human osteoporosis-related gene database. PMID:31086734
Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B. PMID:31086659
PGxO and PGxLOD: a reconciliation of pharmacogenomic knowledge of various provenances, enabling further comparison. PMID:30999867
HumCFS: a database of fragile sites in human chromosomes. PMID:30999860
Exploring the cross-phenotype network region of disease modules reveals concordant and discordant pathways between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. PMID:30997486
In silico Characterization of Human Prion-Like Proteins: Beyond Neurological Diseases. PMID:30971948
FCMDAP: using miRNA family and cluster information to improve the prediction accuracy of disease related miRNAs. PMID:30953512
NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis. PMID:30931480
MorCVD: A Unified Database for Host-Pathogen Protein-Protein Interactions of Cardiovascular Diseases Related to Microbes. PMID:30858555
Integrative Gene Selection on Gene Expression Data: Providing Biological Context to Traditional Approaches. PMID:30785707
Association between DNA methylation in obesity-related genes and body mass index percentile in adolescents. PMID:30765773
Identification of Alzheimer's Disease-Related Genes Based on Data Integration Method. PMID:30740125
Network Pharmacology Integrated Molecular Docking Reveals the Antiosteosarcoma Mechanism of Biochanin A. PMID:30723510
Risk gene-set and pathways in 22q11.2 deletion-related schizophrenia: a genealogical molecular approach. PMID:30710087
NeuroMuscleDB: a Database of Genes Associated with Muscle Development, Neuromuscular Diseases, Ageing, and Neurodegeneration. PMID:30684219
Epigallocatechin‑3‑gallate modulates long non‑coding RNA and mRNA expression profiles in lung cancer cells. PMID:30628683
The Importance of Biologic Knowledge and Gene Expression Context for Genomic Data Interpretation. PMID:30619486
Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and [18F]-Flutemetamol PET Scan Result. PMID:30618716
Global analysis of N6-methyladenosine functions and its disease association using deep learning and network-based methods. PMID:30601803
Construction of a long non‑coding RNA-mediated competitive endogenous RNA network reveals global patterns and regulatory markers in gestational diabetes. PMID:30569156
PathFX provides mechanistic insights into drug efficacy and safety for regulatory review and therapeutic development. PMID:30532240
GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis. PMID:30524706
Drug repositioning using drug-disease vectors based on an integrated network. PMID:30463505
Open Targets Platform: new developments and updates two years on. PMID:30462303
Gene prioritization, communality analysis, networking and metabolic integrated pathway to better understand breast cancer pathogenesis. PMID:30420728
C/VDdb: A multi-omics expression profiling database for a knowledge-driven approach in cardiovascular disease (CVD). PMID:30419069
Gene's hubs in retinal diseases: A retinal disease network. PMID:30417144
Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population. PMID:30402224
PWCDA: Path Weighted Method for Predicting circRNA-Disease Associations. PMID:30384427
Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia. PMID:30365130
Heterogeneous network embedding for identifying symptom candidate genes. PMID:30357378
Genome-wide significant regions in 43 Utah high-risk families implicate multiple genes involved in risk for completed suicide. PMID:30353169
Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease. PMID:30343673
HACER: an atlas of human active enhancers to interpret regulatory variants. PMID:30247654
Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease. PMID:30226566
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. PMID:30224653
Drug Repurposing of Metabolic Agents in Malignant Glioma. PMID:30223473
An analysis of aging-related genes derived from the Genotype-Tissue Expression project (GTEx). PMID:30155276
Burkitt lymphoma-associated network construction and important network motif analysis. PMID:30127896
Phenotype-oriented network analysis for discovering pharmacological effects of natural compounds. PMID:30076354
Searching the overlap between network modules with specific betweeness (S2B) and its application to cross-disease analysis. PMID:30068933
Assembly and Analysis of Unmapped Genome Sequence Reads Reveal Novel Sequence and Variation in Dogs. PMID:30022108
An integrative network-based approach to identify novel disease genes and pathways: a case study in the context of inflammatory bowel disease. PMID:30005591
Network-based approach to prediction and population-based validation of in silico drug repurposing. PMID:30002366
Phenotype-driven gene prioritization for rare diseases using graph convolution on heterogeneous networks. PMID:29980210
Six novel susceptibility loci for coronary artery disease and cerebral infarction identified by longitudinal exome-wide association studies in a Japanese population. PMID:29963304
Gene prioritization using Bayesian matrix factorization with genomic and phenotypic side information. PMID:29949967
Whole-exome sequencing in maya indigenous families: variant in PPP1R3A is associated with type 2 diabetes. PMID:29948331
Computational analysis of mRNA expression profiling in the inner ear reveals candidate transcription factors associated with proliferation, differentiation, and deafness. PMID:29929553
Changing Trends in Computational Drug Repositioning. PMID:29874824
DEXTER: Disease-Expression Relation Extraction from Text. PMID:29860481
Differential Connectivity in Colorectal Cancer Gene Expression Network. PMID:29843204
A workflow for the integrative transcriptomic description of molecular pathology and the suggestion of normalizing compounds, exemplified by Parkinson's disease. PMID:29784986
Multiclass classification for skin cancer profiling based on the integration of heterogeneous gene expression series. PMID:29750795
SRMDAP: SimRank and Density-Based Clustering Recommender Model for miRNA-Disease Association Prediction. PMID:29750163
A TRPV2 interactome-based signature for prognosis in glioblastoma patients. PMID:29719613
MECP2 variation in Rett syndrome-An overview of current coverage of genetic and phenotype data within existing databases. PMID:29704307
The SNPcurator: literature mining of enriched SNP-disease associations. PMID:29688369
Navigating the disease landscape: knowledge representations for contextualizing molecular signatures. PMID:29684165
Detecting Disease Specific Pathway Substructures through an Integrated Systems Biology Approach. PMID:29657291
A Network Pharmacology Approach to Uncover the Multiple Mechanisms of Hedyotis diffusa Willd. on Colorectal Cancer. PMID:29619072
Systematic Evaluation of Molecular Networks for Discovery of Disease Genes. PMID:29605183
Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks. PMID:29504915
Identification of Shared Molecular Signatures Indicate the Susceptibility of Endometriosis to Multiple Sclerosis. PMID:29503661
A systems biology approach to predictive developmental neurotoxicity of a larvicide used in the prevention of Zika virus transmission. PMID:29476864
pBRIT: gene prioritization by correlating functional and phenotypic annotations through integrative data fusion. PMID:29452392
Differential gene expression induced by anti-cancer agent plumbagin is mediated by androgen receptor in prostate cancer cells. PMID:29426892
Integrated Theory- and Data-driven Feature Selection in Gene Expression Data Analysis. PMID:29422764
An integrative functional genomics framework for effective identification of novel regulatory variants in genome-phenome studies. PMID:29378629
Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease. PMID:29361464
TPGLDA: Novel prediction of associations between lncRNAs and diseases via lncRNA-disease-gene tripartite graph. PMID:29348552
Identification of three genetic variants as novel susceptibility loci for body mass index in a Japanese population. PMID:29341862
ModuleDiscoverer: Identification of regulatory modules in protein-protein interaction networks. PMID:29323246
Predicting binary, discrete and continued lncRNA-disease associations via a unified framework based on graph regression. PMID:29322937
Sulfonanilide Derivatives in Identifying Novel Aromatase Inhibitors by Applying Docking, Virtual Screening, and MD Simulations Studies. PMID:29312992
Genome variation and conserved regulation identify genomic regions responsible for strain specific phenotypes in rat. PMID:29272997
Co-expression Network Approach Reveals Functional Similarities among Diseases Affecting Human Skeletal Muscle. PMID:29249983
Hepatic Dysfunction Caused by Consumption of a High-Fat Diet. PMID:29241556
Integrative Analysis to Identify Common Genetic Markers of Metabolic Syndrome, Dementia, and Diabetes. PMID:29229897
Estimation of the proteomic cancer co-expression sub networks by using association estimators. PMID:29145449
Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors. PMID:29126409
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population. PMID:29124443
eRAM: encyclopedia of rare disease annotations for precision medicine. PMID:29106618
FMNL2 with Functions Related to the Cytoskeleton is Partially Regulated by PAX6. PMID:29090051
HEDD: Human Enhancer Disease Database. PMID:29077884
Biological function integrated prediction of severe radiographic progression in rheumatoid arthritis: a nested case control study. PMID:29065906
Systems Biology Genetic Approach Identifies Serotonin Pathway as a Possible Target for Obstructive Sleep Apnea: Results from a Literature Search Review. PMID:29057124
MD-Miner: a network-based approach for personalized drug repositioning. PMID:28984195
Timing and localization of human dystrophin isoform expression provide insights into the cognitive phenotype of Duchenne muscular dystrophy. PMID:28974727
BioCarian: search engine for exploratory searches in heterogeneous biological databases. PMID:28969593
Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson's disease: a longitudinal cohort study and validation. PMID:28958801
Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States. PMID:28957322
SciLite: a platform for displaying text-mined annotations as a means to link research articles with biological data. PMID:28948232
Age-Related Changes in Topological Degradation of White Matter Networks and Gene Expression in Chronic Schizophrenia. PMID:28946750
Systematic integration of biomedical knowledge prioritizes drugs for repurposing. PMID:28936969
PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma. PMID:28925389
Development of zebrafish medulloblastoma-like PNET model by TALEN-mediated somatic gene inactivation. PMID:28903419
Gene-disease associations identify a connectome with shared molecular pathways in human cholangiopathies. PMID:28865156
In silico prediction of novel therapeutic targets using gene-disease association data. PMID:28851378
Domain-based prediction of the human isoform interactome provides insights into the functional impact of alternative splicing. PMID:28846689
Integrative network and transcriptomics-based approach predicts genotype- specific drug combinations for melanoma. PMID:28815138
Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis. PMID:28789679
T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders. PMID:28761062
Genetic and functional characterization of disease associations explains comorbidity. PMID:28740175
Genome-Wide Linkage Analysis of Large Multiple Multigenerational Families Identifies Novel Genetic Loci for Coronary Artery Disease. PMID:28710368
CSmiRTar: Condition-Specific microRNA targets database. PMID:28704505
Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling. PMID:28701918
Arete - candidate gene prioritization using biological network topology with additional evidence types. PMID:28694847
Comorbidities in the diseasome are more apparent than real: What Bayesian filtering reveals about the comorbidities of depression. PMID:28644851
Biomedical text mining for research rigor and integrity: tasks, challenges, directions. PMID:28633401
brain-coX: investigating and visualising gene co-expression in seven human brain transcriptomic datasets. PMID:28595657
Integrative information theoretic network analysis for genome-wide association study of aspirin exacerbated respiratory disease in Korean population. PMID:28589859
Literature evidence in open targets - a target validation platform. PMID:28587637
Identification of oral cancer related candidate genes by integrating protein-protein interactions, gene ontology, pathway analysis and immunohistochemistry. PMID:28559546
GLADIATOR: a global approach for elucidating disease modules. PMID:28549478
Recent advances in predicting gene-disease associations. PMID:28529714
Architecture of the human interactome defines protein communities and disease networks. PMID:28514442
QueryOR: a comprehensive web platform for genetic variant analysis and prioritization. PMID:28454514
VEXOR: an integrative environment for prioritization of functional variants in fine-mapping analysis. PMID:28453673
Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects. PMID:28449705
Neuro-symbolic representation learning on biological knowledge graphs. PMID:28449114
Mining Exosomal Genes for Pancreatic Cancer Targets. PMID:28446531
Gene ORGANizer: linking genes to the organs they affect. PMID:28444223
Human fetal heart specific coexpression network involves congenital heart disease/defect candidate genes. PMID:28436429
Learning from biomedical linked data to suggest valid pharmacogenes. PMID:28427468
Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk-an exploratory study. PMID:28396702
The anatomy of phenotype ontologies: principles, properties and applications. PMID:28387809
DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining. PMID:28387604
Drug repurposing from the perspective of pharmaceutical companies. PMID:28369768
Systematic protein-protein interaction mapping for clinically relevant human GPCRs. PMID:28298427
Identification of Candidate Genes Related to Inflammatory Bowel Disease Using Minimum Redundancy Maximum Relevance, Incremental Feature Selection, and the Shortest-Path Approach. PMID:28293637
A network-based method for mechanistic investigation of Shexiang Baoxin Pill's treatment of cardiovascular diseases. PMID:28272527
Genome-wide analysis of differential RNA editing in epilepsy. PMID:28250018
Characterizing the "POAGome": A bioinformatics-driven approach to primary open-angle glaucoma. PMID:28223208
FocusHeuristics - expression-data-driven network optimization and disease gene prediction. PMID:28205611
An approach to infer putative disease-specific mechanisms using neighboring gene networks. PMID:28200075
Accurately annotate compound effects of genetic variants using a context-sensitive framework. PMID:28158838
Construction of an miRNA-regulated drug-pathway network reveals drug repurposing candidates for myasthenia gravis. PMID:28075449
An analysis of disease-gene relationship from Medline abstracts by DigSee. PMID:28054646
POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins. PMID:28053162
Network Analysis Identifies Disease-Specific Pathways for Parkinson's Disease. PMID:28004338
DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants. PMID:27924018
Brain transcriptome atlases: a computational perspective. PMID:27909802
mutLBSgeneDB: mutated ligand binding site gene DataBase. PMID:27907895
MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search. PMID:27899610
DISCOVERY OF FUNCTIONAL AND DISEASE PATHWAYS BY COMMUNITY DETECTION IN PROTEIN-PROTEIN INTERACTION NETWORKS. PMID:27896987
Large-scale identification of adverse drug reaction-related proteins through a random walk model. PMID:27805066
HIPPIE v2.0: enhancing meaningfulness and reliability of protein-protein interaction networks. PMID:27794551
TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions. PMID:27789689
Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns. PMID:27774140
Fusing literature and full network data improves disease similarity computation. PMID:27578323
In Search of 'Birth Month Genes': Using Existing Data Repositories to Locate Genes Underlying Birth Month-Disease Relationships. PMID:27570668
Causal Mechanistic Regulatory Network for Glioblastoma Deciphered Using Systems Genetics Network Analysis. PMID:27426982
Using the Semantic Web for Rapid Integration of WikiPathways with Other Biological Online Data Resources. PMID:27336457
Purifying selection shapes the coincident SNP distribution of primate coding sequences. PMID:27255481
DNetDB: The human disease network database based on dysfunctional regulation mechanism. PMID:27209279
Candidate gene networks and blood biomarkers of methamphetamine-associated psychosis: an integrative RNA-sequencing report. PMID:27163203
DisGeNET-RDF: harnessing the innovative power of the Semantic Web to explore the genetic basis of diseases. PMID:27153650
Building a glaucoma interaction network using a text mining approach. PMID:27152122
Uncovering disease mechanisms through network biology in the era of Next Generation Sequencing. PMID:27080396
A Consensus Network of Gene Regulatory Factors in the Human Frontal Lobe. PMID:27014338
A Continuous Correlated Beta Process Model for Genetic Ancestry in Admixed Populations. PMID:26966908
Using Multi-objective Optimization to Identify Dynamical Network Biomarkers as Early-warning Signals of Complex Diseases. PMID:26906975
PCOSKB: A KnowledgeBase on genes, diseases, ontology terms and biochemical pathways associated with PolyCystic Ovary Syndrome. PMID:26578565
A functional module-based exploration between inflammation and cancer in esophagus. PMID:26489668
WikiPathways: capturing the full diversity of pathway knowledge. PMID:26481357
Revealing potential molecular targets bridging colitis and colorectal cancer based on multidimensional integration strategy. PMID:26461477
Profiling RNA editing in human tissues: towards the inosinome Atlas. PMID:26449202
Allele, phenotype and disease data at Mouse Genome Informatics: improving access and analysis. PMID:26162703
A pipeline for the systematic identification of non-redundant full-ORF cDNAs for polymorphic and evolutionary divergent genomes: Application to the ascidian Ciona intestinalis. PMID:26025923
PsyGeNET: a knowledge platform on psychiatric disorders and their genes. PMID:25964630
DisGeNET: a Cytoscape plugin to visualize, integrate, search and analyze gene-disease networks PubMed citations: 88.

88 articles citing: DisGeNET: a Cytoscape plugin to visualize, integrate, search and analyze gene-disease networks

XGBG: A Novel Method for Identifying Ovarian Carcinoma Susceptible Genes Based on Deep Learning. PMID:35646648
The mid-secretory endometrial transcriptomic landscape in endometriosis: a meta-analysis. PMID:35464885
DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). PMID:35325185
Human Immune System Diseasome Networks and Female Oviductal Microenvironment: New Horizons to be Discovered. PMID:35154249
New Potential of Roxatidine Acetate Hydrochloride on Atopic Dermatitis Mouse Model, Human Keratinocytes, and Human Skin Equivalent Model. PMID:35002730
Systematic analysis of Long non-coding RNAs reveals diagnostic biomarkers and potential therapeutic drugs for intervertebral disc degeneration. PMID:34402383
Identification of Novel Susceptible Genes of Gastric Cancer Based on Integrated Omics Data. PMID:34354996
TrendyGenes, a computational pipeline for the detection of literature trends in academia and drug discovery. PMID:34344904
DeepGP: An Integrated Deep Learning Method for Endocrine Disease Gene Prediction Using Omics Data. PMID:34295899
Mechanism of protective effect of xuan-bai-cheng-qi decoction on LPS-induced acute lung injury based on an integrated network pharmacology and RNA-sequencing approach. PMID:34183011
miRNAs Potentially Involved in Post Lung Transplant-Obliterative Bronchiolitis: The Role of miR-21-5p. PMID:33804639
Constitution of a comprehensive phytochemical profile and network pharmacology based investigation to decipher molecular mechanisms of Teucrium polium L. in the treatment of type 2 diabetes mellitus. PMID:33150068
Named Entity Recognition and Relation Detection for Biomedical Information Extraction. PMID:32984300
Identification of early stage recurrence endometrial cancer biomarkers using bioinformatics tools. PMID:32705231
BioHackathon 2015: Semantics of data for life sciences and reproducible research. PMID:32308977
Prediction of new associations between ncRNAs and diseases exploiting multi-type hierarchical clustering. PMID:32093606
Systematic analysis of lncRNA and microRNA dynamic features reveals diagnostic and prognostic biomarkers of myocardial infarction. PMID:31927529
TopControl: A Tool to Prioritize Candidate Disease-associated Genes based on Topological Network Features. PMID:31857653
A novel algorithm based on bi-random walks to identify disease-related lncRNAs. PMID:31760932
Biomarker identification of hepatocellular carcinoma using a methodical literature mining strategy. PMID:31725857
The DisGeNET knowledge platform for disease genomics: 2019 update. PMID:31680165
A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. PMID:31494632
Systematic identification and analysis of dysregulated miRNA and transcription factor feed-forward loops in hypertrophic cardiomyopathy. PMID:30338905
PTMD: A Database of Human Disease-associated Post-translational Modifications. PMID:30244175
Computational resources associating diseases with genotypes, phenotypes and exposures. PMID:30102366
DEXTER: Disease-Expression Relation Extraction from Text. PMID:29860481
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. PMID:29808027
Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain. PMID:29435496
Protein-protein interaction analysis to identify biomarker networks for endometriosis. PMID:29201163
An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer. PMID:29152079
Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors. PMID:29126409
Chromosome preference of disease genes and vectorization for the prediction of non-coding disease genes. PMID:29108274
MD-Miner: a network-based approach for personalized drug repositioning. PMID:28984195
Integrative Systems Biology Investigation of Fabry Disease. PMID:28933415
RNA-Seq of Human Neural Progenitor Cells Exposed to Lead (Pb) Reveals Transcriptome Dynamics, Splicing Alterations and Disease Risk Associations. PMID:28903495
Genetic and functional characterization of disease associations explains comorbidity. PMID:28740175
Genome-Wide Linkage Analysis of Large Multiple Multigenerational Families Identifies Novel Genetic Loci for Coronary Artery Disease. PMID:28710368
A simple mathematical approach to the analysis of polypharmacology and polyspecificity data. PMID:28690829
Enriching plausible new hypothesis generation in PubMed. PMID:28678852
Randomization Strategies Affect Motif Significance Analysis in TF-miRNA-Gene Regulatory Networks. PMID:28675749
GenePANDA-a novel network-based gene prioritizing tool for complex diseases. PMID:28252032
Genome-wide analysis of differential RNA editing in epilepsy. PMID:28250018
Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain. PMID:28238550
Characterizing the "POAGome": A bioinformatics-driven approach to primary open-angle glaucoma. PMID:28223208
DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants. PMID:27924018
DiseaseMeth version 2.0: a major expansion and update of the human disease methylation database. PMID:27899673
Review on Graph Clustering and Subgraph Similarity Based Analysis of Neurological Disorders. PMID:27258269
An Integrated Data Driven Approach to Drug Repositioning Using Gene-Disease Associations. PMID:27196054
Building a glaucoma interaction network using a text mining approach. PMID:27152122
Integrating text mining, data mining, and network analysis for identifying genetic breast cancer trends. PMID:27112211
New strategy for drug discovery by large-scale association analysis of molecular networks of different species. PMID:26912056
Mining integrated semantic networks for drug repositioning opportunities. PMID:26844016
Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa). PMID:26814189
Integrated Transcriptomic-Proteomic Analysis Using a Proteogenomic Workflow Refines Rat Genome Annotation. PMID:26560066
Cell type-selective disease-association of genes under high regulatory load. PMID:26338775
Exploring the cellular basis of human disease through a large-scale mapping of deleterious genes to cell types. PMID:26330083
MicroRNA and transcription factor mediated regulatory network analysis reveals critical regulators and regulatory modules in myocardial infarction. PMID:26258537
Molecular Architecture of Spinal Cord Injury Protein Interaction Network. PMID:26241741
How to build personalized multi-omics comorbidity profiles. PMID:26157799
TFmiR: a web server for constructing and analyzing disease-specific transcription factor and miRNA co-regulatory networks. PMID:25943543
Pathway reporter genes define molecular phenotypes of human cells. PMID:25903797
Extraction of relations between genes and diseases from text and large-scale data analysis: implications for translational research. PMID:25886734
DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes. PMID:25877637
Biological databases for human research. PMID:25712261
Discovery of new candidate genes related to brain development using protein interaction information. PMID:25635857
ncPred: ncRNA-Disease Association Prediction through Tripartite Network-Based Inference. PMID:25566534
Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014. PMID:25531178
Associating disease-related genetic variants in intergenic regions to the genes they impact. PMID:25374782
Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization. PMID:25352550
Organ system heterogeneity DB: a database for the visualization of phenotypes at the organ system level. PMID:25313158
Molecularly and clinically related drugs and diseases are enriched in phenotypically similar drug-disease pairs. PMID:25276232
Network medicine analysis of COPD multimorbidities. PMID:25248857
Systematic analysis of gene properties influencing organ system phenotypes in mammalian perturbations. PMID:25061072
A knowledge-driven approach to extract disease-related biomarkers from the literature. PMID:24839601
Clinical proteomic biomarkers: relevant issues on study design & technical considerations in biomarker development. PMID:24679154
Prioritizing disease-linked variants, genes, and pathways with an interactive whole-genome analysis pipeline. PMID:24478219
Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes. PMID:24474197
A computational framework to infer human disease-associated long noncoding RNAs. PMID:24392133
Integrated analysis of transcript-level regulation of metabolism reveals disease-relevant nodes of the human metabolic network. PMID:24198249
Detection of differentially methylated gene promoters in failing and nonfailing human left ventricle myocardium using computation analysis. PMID:23695888
Choline protects against cardiac hypertrophy induced by increased after-load. PMID:23493786
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review. PMID:23384594
ChemProt-2.0: visual navigation in a disease chemical biology database. PMID:23185041
State of the art in silico tools for the study of signaling pathways in cancer. PMID:22837650
Automatic filtering and substantiation of drug safety signals. PMID:22496632
Charting the NF-κB pathway interactome map. PMID:22403694
iCTNet: a Cytoscape plugin to produce and analyze integrative complex traits networks. PMID:21943367
Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases. PMID:21695124
Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases PubMed citations: 67.

67 articles citing: Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases

Identification of hub pathways and drug candidates in gastric cancer through systems biology. PMID:35650297
The mid-secretory endometrial transcriptomic landscape in endometriosis: a meta-analysis. PMID:35464885
Scaling up oligogenic diseases research with OLIDA: the Oligogenic Diseases Database. PMID:35411390
Human Immune System Diseasome Networks and Female Oviductal Microenvironment: New Horizons to be Discovered. PMID:35154249
Translational Informatics for Natural Products as Antidepressant Agents. PMID:35127696
Case Report: A Disease Phenotype of Rett Syndrome and Neurofibromatosis Resulting from A Bilocus Variant Combination. PMID:35122187
A multiple network-based bioinformatics pipeline for the study of molecular mechanisms in oncological diseases for personalized medicine. PMID:34050359
Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19. PMID:33123533
Unsupervised Learning and Multipartite Network Models: A Promising Approach for Understanding Traditional Medicine. PMID:32982738
Integrated Analysis of Tissue-Specific Promoter Methylation and Gene Expression Profile in Complex Diseases. PMID:32709145
Seeking Windows of Opportunity to Shape Lifelong Immune Health: A Network-Based Strategy to Predict and Prioritize Markers of Early Life Immune Modulation. PMID:32362896
Predicting disease-causing variant combinations. PMID:31127050
Mechanism-based disease similarity. PMID:30854526
Functional homogeneity and specificity of topological modules in human proteome. PMID:30717667
Integrating molecular networks with genetic variant interpretation for precision medicine. PMID:30548534
OligoPVP: Phenotype-driven analysis of individual genomic information to prioritize oligogenic disease variants. PMID:30279426
Gene prioritization using Bayesian matrix factorization with genomic and phenotypic side information. PMID:29949967
Differential gene expression induced by anti-cancer agent plumbagin is mediated by androgen receptor in prostate cancer cells. PMID:29426892
Systematic identification of latent disease-gene associations from PubMed articles. PMID:29373609
Use of methylation profiling to identify significant differentially methylated genes in bone marrow mesenchymal stromal cells from acute myeloid leukemia. PMID:29207054
Computational derivation of a molecular framework for hair follicle biology from disease genes. PMID:29176608
Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors. PMID:29126409
Strength of functional signature correlates with effect size in autism. PMID:28687074
Data on overlapping brain disorders and emerging drug targets in human Dopamine Receptors Interaction Network. PMID:28480319
Characterizing the "POAGome": A bioinformatics-driven approach to primary open-angle glaucoma. PMID:28223208
An approach to infer putative disease-specific mechanisms using neighboring gene networks. PMID:28200075
PERCH: A Unified Framework for Disease Gene Prioritization. PMID:27995669
Fusing literature and full network data improves disease similarity computation. PMID:27578323
Context-specific functional module based drug efficacy prediction. PMID:27490093
Identify bilayer modules via pseudo-3D clustering: applications to miRNA-gene bilayer networks. PMID:27484480
Gene-Disease Interaction Retrieval from Multiple Sources: A Network Based Method. PMID:27478829
Representing and querying disease networks using graph databases. PMID:27462371
An Integrated Data Driven Approach to Drug Repositioning Using Gene-Disease Associations. PMID:27196054
Building a glaucoma interaction network using a text mining approach. PMID:27152122
The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation. PMID:27145901
Integrating text mining, data mining, and network analysis for identifying genetic breast cancer trends. PMID:27112211
Systems psychopharmacology: A network approach to developing novel therapies. PMID:27014599
Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa). PMID:26814189
Integrative analysis of human protein, function and disease networks. PMID:26399914
Cell type-selective disease-association of genes under high regulatory load. PMID:26338775
Exploring the cellular basis of human disease through a large-scale mapping of deleterious genes to cell types. PMID:26330083
Enrichment Analysis Identifies Functional MicroRNA-Disease Associations in Humans. PMID:26296081
Novel scripts for improved annotation and selection of variants from whole exome sequencing in cancer research. PMID:26150983
DeCoaD: determining correlations among diseases using protein interaction networks. PMID:26047952
DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes. PMID:25877637
Applications of systems approaches in the study of rheumatic diseases. PMID:25750554
The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network. PMID:25687571
Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. PMID:25544563
Insights from systems pharmacology into cardiovascular drug discovery and therapy. PMID:25539592
Locus heterogeneity disease genes encode proteins with high interconnectivity in the human protein interaction network. PMID:25538735
Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014. PMID:25531178
In silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases. PMID:25486901
Diffusion of information throughout the host interactome reveals gene expression variations in network proximity to target proteins of hepatitis C virus. PMID:25461596
Protein-protein interaction networks (PPI) and complex diseases. PMID:25436094
Network Analysis of Cancer-focused Association Network Reveals Distinct Network Association Patterns. PMID:25368509
Relating diseases by integrating gene associations and information flow through protein interaction network. PMID:25360770
Network analysis identifies SOD2 mRNA as a potential biomarker for Parkinson's disease. PMID:25279756
Molecularly and clinically related drugs and diseases are enriched in phenotypically similar drug-disease pairs. PMID:25276232
Predicting disease associations via biological network analysis. PMID:25228247
Network-based analysis reveals distinct association patterns in a semantic MEDLINE-based drug-disease-gene network. PMID:25170419
Systematic analysis of gene properties influencing organ system phenotypes in mammalian perturbations. PMID:25061072
A computational framework to infer human disease-associated long noncoding RNAs. PMID:24392133
MalaCards: an integrated compendium for diseases and their annotation. PMID:23584832
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review. PMID:23384594
Inferring novel gene-disease associations using Medical Subject Heading Over-representation Profiles. PMID:23021552
Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates. PMID:22870394
Formal concept analysis of disease similarity. PMID:22779049

https://doi.org/10.1016/j.csbj.2021.05.015

http://dx.doi.org/10.1093/database/bav028

http://dx.doi.org/10.1093/nar/gkw943

http://dx.doi.org/10.1093/bioinformatics/btq538

http://dx.doi.org/10.1093/bioinformatics/btw214

http://dx.doi.org/10.1371/journal.pone.0020284

http://dx.doi.org/10.1093/nar/gkz1021

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disease
metasource: Fairsharing.org
version: FAIRsharing.org: DisGeNET; DisGeNET: a knowledge base for disease genomics; DOI: https://doi.org/10.25504/FAIRsharing.fssydn; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

metasource: re3data.org
version: re3data.org: DisGeNET; editing status 2021-09-09; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31NJMR9 last accessed: 2022-11-04

gene
metasource: Fairsharing.org
version: FAIRsharing.org: DisGeNET; DisGeNET: a knowledge base for disease genomics; DOI: https://doi.org/10.25504/FAIRsharing.fssydn; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

genetic polymorphism
metasource: Fairsharing.org
version: FAIRsharing.org: DisGeNET; DisGeNET: a knowledge base for disease genomics; DOI: https://doi.org/10.25504/FAIRsharing.fssydn; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

mutation
metasource: Fairsharing.org
version: FAIRsharing.org: DisGeNET; DisGeNET: a knowledge base for disease genomics; DOI: https://doi.org/10.25504/FAIRsharing.fssydn; Last edited: July 7, 2021, 8:36 a.m.; Last accessed: Jan 03 2022 7:07 p.m.

human genes and diseases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

gene-, system- or disease-specific databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

covid-19
metasource: re3data.org
version: re3data.org: DisGeNET; editing status 2021-09-09; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31NJMR9 last accessed: 2022-11-04

fair
metasource: re3data.org
version: re3data.org: DisGeNET; editing status 2021-09-09; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R31NJMR9 last accessed: 2022-11-04

molecular interactions, pathways and networks
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

biomedical science
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

genetic variation
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

natural language processing
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

ontology and terminology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

bioinformatics
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

data integration and warehousing
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

data identity and mapping
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

translational medicine
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

pathology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

genotype and phenotype
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

medical informatics
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

rare diseases
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:12.659186

disease gene polymorphism mutation human genes and diseases gene-, system- or disease-specific covid-19 molecular interactions, pathways and networks biomedical science genetic variation natural language processing ontology and terminology bioinformatics data integration and warehousing data identity and mapping translational medicine pathology genotype and phenotype medical informatics rare diseases

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DISNOR

Pharmacogenomics Knowledge Base

Open Targets

LncRNADisease

Gephebase

Database of Genotypes and Phenotypes

GEneSTATION

Mitochondrial Disease Sequence Data Resource

DDMGD

ClinVar

GWAS Central

MalaCards

Human disease methylation database

Human Phenotype Ontology

G2Cdb

PCOSKB

ImmunoBase

Comparative Toxicogenomics Database

Gene Ontology

Disease Ontology