Laminin Database

Other names: Laminin database, laminin_database

Laminins (LM) correspond to a large number of heretotrimeric glycoproteins, playing and a major role in several cell functions, including differentiation, proliferation, adhesion, and migration [1-3]. In addition to binding to other extracellular matrix proteins, laminins bind specific cell membrane receptors, several of them are integrins, such as α3β1, α6β1, α6β4 and α7β1 [2, 4].For example, laminin-mediated interactions are relevant for the entrance of T cell precursors into the thymus [5, 6], the migration of developing thymocytes, both in mice and humans [7, 8 , 9], as well as in peripheral lymphoid organs [10, 11]. Also, activated T cells use laminin receptors to migrate across endothelial barriers, as exemplified by the role of laminin isoforms in leukocyte extravasation in the central nervous system [12, 13].Moreover, the effector immune function in rejection of heart grafts can be abrogated by blocking laminin- α6β1 interaction with antibodies specific for the ligand or the corresponding receptor [14, 15]. In fact, blockade of the α6β1 receptor also prevents neutrophils to cross basement lamina [16]. Lastly, laminins are presently demonstrated to be involved in pathophysiology and/or pathogenesis in neuromuscular and neurodegenerative diseases [17, 18, 19, 20].Taking together, one can easily realize the high degree of biological complexity in laminin-mediated interactions, in both health and disease. The Laminin Database provides a comprehensive repository for public data concerning laminins and related proteins, which is collected and manually curated and annotated, allowing the user to easily retrieve highthroughput data available, but so far dispersed in the net. Further, external links are provided underlying data infrastructure for services such as Ensembl, UniProt and NCBI. The LM Database includes the 16 known laminins, 10 integrin type receptors, 9 non integrin type receptors and 6 extracellular laminin-binding proteins.For each protein provided at the database, the following items are stored: summary, information concerning protein details, gene structure, gene expression and tissue distribution, therapy and reference(s) to relevant paper(s). The information can be retrieved for three particular organisms, Homo sapiens, Mus musculus and Ratus novergicus. The database is available on line at you wish to make contributions to or comment on the database, please contact [email protected]




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