Other names: dbmae

Autosomal monoallelic expression (MAE) refers to mitotically stable, epigenetically controlled allele-specific expression of autosomal genes, with the initial non-predetermined ('random') choice of thetranscriptional activity of the two alleles maintained in a given clonal cell lineage [recent reviewsinclude refs. (1-3)]. The database of autosomal monoallelic expression (dbMAE) incorporates datafrom multiple recent reports of genome-wide analyses. These include transcriptome-wide analysesof allelic imbalance in clonal cell populations based on sequence polymorphisms, as well as indirectidentification, based on a specific chromatin signature present in MAE gene bodies. The databasemaintains a clear distinction between these types of evidence, listing the entry's MAE statusaccording to all available sources. The user can also access the full set of data for each gene. At thetime of publication, the database contains MAE calls for over 700 human and 16,000 mouse geneswith experimental evidence of allelic bias as assessed in four tissue types. There are close to 5,000corresponding positively confirmed instances of biallelic expression in human and more than 21,000in mouse. In addition, the database includes MAE and biallelic calls based on genome-widechromatin analysis for seven human and 21 murine cell types and tissues.




human genes and diseases general human genetics epigenetics gene expression genetic variation rare diseases

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