FAIRsharing.6L6MjA; Last edited: Jan. 9, 2019, 3:06 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

Other names: cBioPortal

The cBioPortal for Cancer Genomics provides visualization, analysis and download of large-scale cancer genomics data sets.

Webpage:

http://www.cbioportal.org

Licence:

Name: GNU Affero General Public License
URL: http://www.gnu.org/licenses/agpl-3.0.html

Publications:

Publications
More detailed information about this field from each metasource.

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
PMID: 22588877
metasource: Fairsharing.org
version: FAIRsharing.org: cBioPortal; cBioPortal for Cancer Genomics; DOI: https://doi.org/10.25504/FAIRsharing.6L6MjA; Last edited: Jan. 9, 2019, 3:06 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
PMID: 23550210
metasource: Fairsharing.org
version: FAIRsharing.org: cBioPortal; cBioPortal for Cancer Genomics; DOI: https://doi.org/10.25504/FAIRsharing.6L6MjA; Last edited: Jan. 9, 2019, 3:06 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

http://dx.doi.org/10.1126/scisignal.2004088
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data PubMed citations: 6909.

6909 articles citing: The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

BCHE as a Prognostic Biomarker in Endometrial Cancer and Its Correlation with Immunity. PMID:35915658
Comprehensive Pan-Cancer Analysis of Senescence With Cancer Prognosis and Immunotherapy. PMID:35911954
Prognostic impact of PDGFRA gain/amplification and MGMT promoter methylation status in patients with IDH wild-type glioblastoma. PMID:35911637
Molecular Landscape of ERBB2 Alterations in 14,956 Solid Tumors. PMID:35911441
High expression of ZFP36L2 correlates with the prognosis and immune infiltration in lower-grade glioma. PMID:35910229
A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML. PMID:35906694
Proteotranscriptomics of ocular adnexal B-cell lymphoma reveals an oncogenic role of alternative splicing and identifies a diagnostic marker. PMID:35906682
Deoxythymidylate Kinase as a Promising Marker for Predicting Prognosis and Immune Cell Infiltration of Pan-cancer. PMID:35903153
Mutant p53 drives an immune cold tumor immune microenvironment in oral squamous cell carcinoma. PMID:35902768
Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes. PMID:35902588
The hexokinase "HKDC1" interaction with the mitochondria is essential for liver cancer progression. PMID:35902556
JMJD8 Is an M2 Macrophage Biomarker, and It Associates With DNA Damage Repair to Facilitate Stemness Maintenance, Chemoresistance, and Immunosuppression in Pan-Cancer. PMID:35898493
Analysis of the Effect of SNAI Family in Breast Cancer and Immune Cell. PMID:35898399
GRHL2 Expression Functions in Breast Cancer Aggressiveness and Could Serve as Prognostic and Diagnostic Biomarker for Breast Cancer. PMID:35898391
Genomic Predictors of Recurrence Patterns After Complete Resection of Colorectal Liver Metastases and Adjuvant Hepatic Artery Infusion Chemotherapy. PMID:35896920
Pan-Cancer Analysis Reveals the Prognostic Potential of the THAP9/THAP9-AS1 Sense-Antisense Gene Pair in Human Cancers. PMID:35893234
The Identification by Exome Sequencing of Candidate Genes in BRCA-Negative Tunisian Patients at a High Risk of Hereditary Breast/Ovarian Cancer. PMID:35893033
FXYD3 Expression Predicts Poor Prognosis in Renal Cell Carcinoma with Immunosuppressive Tumor Microenvironment. PMID:35892856
Identification of Malignant Cell Populations Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer Using Single-Cell RNA Sequencing. PMID:35892844
AKT1 Transcriptomic Landscape in Breast Cancer Cells. PMID:35892586
Breast Cancer during Pregnancy as a Special Type of Early-Onset Breast Cancer: Analysis of the Tumor Immune Microenvironment and Risk Profiles. PMID:35892583
Biomarkers Regulated by Lipid-Soluble Vitamins in Glioblastoma. PMID:35889829
Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases. PMID:35887358
Integrated Workflow for the Label-Free Isolation and Genomic Analysis of Single Circulating Tumor Cells in Pancreatic Cancer. PMID:35887203
Efficient Identification of the MYC Regulator with the Use of the CRISPR Library and Context-Matched Database Screenings. PMID:35887071
Identification of Antitumor miR-30e-5p Controlled Genes; Diagnostic and Prognostic Biomarkers for Head and Neck Squamous Cell Carcinoma. PMID:35886008
Oleocanthal Attenuates Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence by Targeting SMYD2. PMID:35884603
The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth. PMID:35884550
Genomic Landscape, Clinical Features and Outcomes of Non-Small Cell Lung Cancer Patients Harboring BRAF Alterations of Distinct Functional Classes. PMID:35884534
Targeted Next-Generation Sequencing of Thymic Epithelial Tumours Revealed Pathogenic Variants in KIT, ERBB2, KRAS, and TP53 in 30% of Thymic Carcinomas. PMID:35884448
Focal Adhesion Kinase Provides a Collateral Vulnerability That Can Be Leveraged to Improve mTORC1 Inhibitor Efficacy. PMID:35884439
PRIM2 Promotes Cell Cycle and Tumor Progression in p53-Mutant Lung Cancer. PMID:35884433
Homo and Heterotypic Cellular Cross-Talk in Epithelial Ovarian Cancer Impart Pro-Tumorigenic Properties through Differential Activation of the Notch3 Pathway. PMID:35884426
Interleukin-11: A Potential Biomarker and Molecular Therapeutic Target in Non-Small Cell Lung Cancer. PMID:35883698
Landscape of genetic variants in sporadic meningiomas captured with clinical genomics. PMID:35881312
Oncogene addiction to GNAS in GNASR201 mutant tumors. PMID:35879396
The Aminoacyl-tRNA Synthetase and tRNA Expression Levels Are Deregulated in Cancer and Correlate Independently with Patient Survival. PMID:35877431
Using AI-Based Evolutionary Algorithms to Elucidate Adult Brain Tumor (Glioma) Etiology Associated with IDH1 for Therapeutic Target Identification. PMID:35877430
Deciphering Prognostic Value of TTN and Its Correlation With Immune Infiltration in Lung Adenocarcinoma. PMID:35875159
P-Rex1 Signaling Hub in Lower Grade Glioma Patients, Found by In Silico Data Mining, Correlates With Reduced Survival and Augmented Immune Tumor Microenvironment. PMID:35875157
The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma. PMID:35875075
Comprehensive Analyses of Immune Subtypes of Stomach Adenocarcinoma for mRNA Vaccination. PMID:35874675
Identifying an Immune-Related Gene ST8SIA1 as a Novel Target in Patients With Clear-Cell Renal Cell Carcinoma. PMID:35873547
Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer Analysis. PMID:35873470
Discovering the drivers of clonal hematopoiesis. PMID:35871184
Landscape of somatic alterations in large-scale solid tumors from an Asian population. PMID:35871175
A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer. PMID:35869079
Growth hormone receptor antagonism downregulates ATP-binding cassette transporters contributing to improved drug efficacy against melanoma and hepatocarcinoma in vivo. PMID:35865483
The Hippo Pathway Effector Transcriptional Co-activator With PDZ-Binding Motif Correlates With Clinical Prognosis and Immune Infiltration in Colorectal Cancer. PMID:35865173
Data driven and biophysical insights into the regulation of trafficking vesicles by extracellular matrix stiffness. PMID:35865140
PRMT5 acts as a tumor suppressor by inhibiting Wnt/β-catenin signaling in murine gastric tumorigenesis. PMID:35864961
PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib. PMID:35864202
HIF1α: A Novel Biomarker with Potential Prognostic and Immunotherapy in Pan-cancer. PMID:35860430
Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. PMID:35858357
Tumor antigens and immune subtypes of glioblastoma: the fundamentals of mRNA vaccine and individualized immunotherapy development. PMID:35855914
Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers. PMID:35853939
The splicing factor SF3B4 drives proliferation and invasion in cervical cancer by regulating SPAG5. PMID:35853859
Identification of a Prognostic Transcriptome Signature for Hepatocellular Carcinoma with Lymph Node Metastasis. PMID:35847584
Identification of Potential Antigens for Developing mRNA Vaccine for Immunologically Cold Mesothelioma. PMID:35846349
Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer. PMID:35846126
Expression and Prognostic Role of Glia Maturation Factor-γ in Gliomas. PMID:35845613
Comprehensive Computational Analysis of Honokiol Targets for Cell Cycle Inhibition and Immunotherapy in Metastatic Breast Cancer Stem Cells. PMID:35845599
The TTYH3/MK5 Positive Feedback Loop regulates Tumor Progression via GSK3-β/β-catenin signaling in HCC. PMID:35844789
DCBLD1 Overexpression Is Associated With a Poor Prognosis in Head and Neck Squamous Cell Carcinoma. PMID:35844572
Loss-of-function of the hippo transducer TAZ reduces mammary tumor growth through a myeloid-derived suppressor cell-dependent mechanism. PMID:35840667
Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis. PMID:35840569
Alterations in Somatic Driver Genes Are Associated with Response to Neoadjuvant FOLFIRINOX in Patients with Localized Pancreatic Ductal Adenocarcinoma. PMID:35839413
MUC1 expressing tumor growth was retarded after human mucin 1 (MUC1) plasmid DNA immunization. PMID:35839304
Overexpression of LIMA1 Indicates Poor Prognosis and Promotes Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma. PMID:35837368
Decoding signal transducer and activator of transcription 1 across various cancers through data mining and integrative analysis. PMID:35836889
Screening a novel six critical gene-based system of diagnostic and prognostic biomarkers in prostate adenocarcinoma patients with different clinical variables. PMID:35836886
Overexpressed SNRPB/D1/D3/E/F/G correlate with poor survival and immune infiltration in hepatocellular carcinoma. PMID:35836882
MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms. PMID:35821197
PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance. PMID:35820706
Downregulation of PGM5 expression correlates with tumor progression and poor prognosis in human prostate cancer. PMID:35819729
Identification of mRNA vaccines and conserved ferroptosis related immune landscape for individual precision treatment in bladder cancer. PMID:35818395
Genomic instability genes in lung and colon adenocarcinoma indicate organ specificity of transcriptomic impact on Copy Number Alterations. PMID:35817785
Gallic acid induces T-helper-1-like Treg cells and strengthens immune checkpoint blockade efficacy. PMID:35817479
Extra Spindle Pole Bodies-Like 1 Serves as a Prognostic Biomarker and Promotes Lung Adenocarcinoma Metastasis. PMID:35814478
Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer. PMID:35814476
S645C Point Mutation Suppresses Degradation of EGFR to Promote Progression of Glioblastoma. PMID:35814475
Identification of Novel Tumor Antigens and the Immune Landscapes of Bladder Cancer Patients for mRNA Vaccine Development. PMID:35814377
TRPs in Ovarian Serous Cystadenocarcinoma: The Expression Patterns, Prognostic Roles, and Potential Therapeutic Targets. PMID:35813831
Uterine Sarcoma Presenting as Hypercapnic Respiratory Failure. PMID:35813696
High SLC20A1 Expression Is Associated With Poor Prognosis for Radiotherapy of Estrogen Receptor-positive Breast Cancer. PMID:35813014
The Role of P4HA1 in Multiple Cancer Types and its Potential as a Target in Renal Cell Carcinoma. PMID:35812752
The clinical relevance of unfolded protein response signaling in breast cancer. PMID:35812054
Genetic variation associated with condensate dysregulation in disease. PMID:35809564
Identification of growth hormone receptor as a relevant target for precision medicine in low-EGFR expressing glioblastoma. PMID:35808822
Prognostic Ability of Enhancer RNAs in Metastasis of Non-Small Cell Lung Cancer. PMID:35807355
Prognostic Significance of HMGA1 Expression in Lung Cancer Based on Bioinformatics Analysis. PMID:35805937
Aldehyde Dehydrogenase 1B1 Is Implicated in DNA Damage Response in Human Colorectal Adenocarcinoma. PMID:35805102
High Expression of PRNP Predicts Poor Prognosis in Korean Patients with Gastric Cancer. PMID:35804944
Theranostic Potentials of Gold Nanomaterials in Hematological Malignancies. PMID:35804818
Therapy-related clonal cytopenia as a precursor to therapy-related myeloid neoplasms. PMID:35803921
The role of toll-like receptors (TLRs) in pan-cancer. PMID:35801728
Patients deriving long-term benefit from immune checkpoint inhibitors demonstrate conserved patterns of site-specific mutations. PMID:35798829
CPDR: An R Package of Recommending Personalized Drugs for Cancer Patients by Reversing the Individual's Disease-Related Signature. PMID:35795573
SEMA4D/PlexinB1 promotes AML progression via activation of PI3K/Akt signaling. PMID:35794581
Molecular dissection of a hyper-aggressive CBFB-MYH11/FLT3-ITD-positive acute myeloid leukemia. PMID:35794567
Syringin exerts anti-breast cancer effects through PI3K-AKT and EGFR-RAS-RAF pathways. PMID:35794555
Intratumoral PDGFB gene predominantly expressed in endothelial cells is associated with angiogenesis and lymphangiogenesis, but not with metastasis in breast cancer. PMID:35793004
A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic Targets. PMID:35791393
Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. PMID:35788181
SEMA3C Supports Pancreatic Cancer Progression by Regulating the Autophagy Process and Tumor Immune Microenvironment. PMID:35785187
A Comprehensive Pan-Cancer Analysis of the Tumorigenic Role of Matrix Metallopeptidase 7 (MMP7) Across Human Cancers. PMID:35785154
Activation Versus Inhibition of IGF1R: A Dual Role in Breast Tumorigenesis. PMID:35784559
ECM1 is associated with endocrine resistance in ER+ breast cancers. PMID:35784388
Lighting a Fire: Gasdermin-Mediated Pyroptosis Remodels the Glioma Microenvironment and Promotes Immune Checkpoint Blockade Response. PMID:35784306
Genomic Landscape of Metastatic Lymph Nodes and Primary Tumors in Non-Small-Cell Lung Cancer. PMID:35783357
RecQ Helicase Somatic Alterations in Cancer. PMID:35782872
Identification of SHCBP1 as a potential biomarker involving diagnosis, prognosis, and tumor immune microenvironment across multiple cancers. PMID:35782736
TumorDecon: A digital cytometry software. PMID:35782394
Clinical, histopathological, and molecular features of IDH-wildtype indolent diffuse glioma: comparison with typical glioblastoma. PMID:35779193
Correlation of changes in subclonal architecture with progression in the MMRF CoMMpass study. PMID:35777247
ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform. PMID:35776213
Identification of Hub Genes for Early Diagnosis and Predicting Prognosis in Colon Adenocarcinoma. PMID:35774271
Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy. PMID:35773527
Disassembly of α6β4-mediated hemidesmosomal adhesions promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin to focal adhesions. PMID:35773413
YAP1 induces invadopodia formation by transcriptionally activating TIAM1 through enhancer in breast cancer. PMID:35773411
The close interaction between hypoxia-related proteins and metastasis in pancarcinomas. PMID:35773405
N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma. PMID:35773310
Downregulation of DNMT3A Attenuates the Warburg Effect, Proliferation, and Invasion via Promoting the Inhibition of miR-603 on HK2 in Ovarian Cancer. PMID:35770296
Exonuclease 1 is a Potential Diagnostic and Prognostic Biomarker in Hepatocellular Carcinoma. PMID:35769911
Epigenetic dysregulation in meningiomas. PMID:35769412
Is loss of p53 a driver of ductal carcinoma in situ progression? PMID:35764786
Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma. PMID:35761940
Proceedings of the fifth international Molecular Pathological Epidemiology (MPE) meeting. PMID:35759080
Prognostic Implication and Immunological Role of PSMD2 in Lung Adenocarcinoma. PMID:35754829
A Systematic Analysis Reveals the Prognostic and Immunological Role of Reptin/RUVBL2 in Human Tumors. PMID:35754815
A new deep learning technique reveals the exclusive functional contributions of individual cancer mutations. PMID:35753349
Targeting signaling pathways in prostate cancer: mechanisms and clinical trials. PMID:35750683
POC1A, prognostic biomarker of immunosuppressive microenvironment in cancer. PMID:35748773
Precision Medicine in Head and Neck Cancers: Genomic and Preclinical Approaches. PMID:35743639
Targeting Cell Cycle Progression in HER2+ Breast Cancer: An Emerging Treatment Opportunity. PMID:35742993
Gene Expression of the D-Series Resolvin Pathway Predicts Activation of Anti-Tumor Immunity and Clinical Outcomes in Head and Neck Cancer. PMID:35742918
Delineation of Pathogenomic Insights of Breast Cancer in Young Women. PMID:35741056
Identifying the Potential Roles of PBX4 in Human Cancers Based on Integrative Analysis. PMID:35740947
NR2F1, a Tumor Dormancy Marker, Is Expressed Predominantly in Cancer-Associated Fibroblasts and Is Associated with Suppressed Breast Cancer Cell Proliferation. PMID:35740627
MCC Gene Silencing Is a CpG Island Methylator Phenotype-Associated Factor That Predisposes Colon Cancer Cells to Irinotecan and Olaparib. PMID:35740525
Metabolomic Analysis Points to Bioactive Lipid Species and Acireductone Dioxygenase 1 (ADI1) as Potential Therapeutic Targets in Poor Prognosis Endometrial Cancer. PMID:35740505
Impact of Endoluminal Radiofrequency Ablation on Immunity in Pancreatic Cancer and Cholangiocarcinoma. PMID:35740353
Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia. PMID:35739278
Expression and prognosis analysis of mitochondrial ribosomal protein family in breast cancer. PMID:35739158
Efficacy of Ipilimumab vs FOLFOX in Combination With Nivolumab and Trastuzumab in Patients With Previously Untreated ERBB2-Positive Esophagogastric Adenocarcinoma: The AIO INTEGA Randomized Clinical Trial. PMID:35737383
A Case Study of Clinical Response to Rucaparib in a Patient with Metastatic Castration-Resistant Prostate Cancer and a RAD51B Alteration. PMID:35735442
Neuroendocrine pathways and breast cancer progression: a pooled analysis of somatic mutations and gene expression from two large breast cancer cohorts. PMID:35729536
WT1-specific TCRs directed against newly identified peptides install antitumor reactivity against acute myeloid leukemia and ovarian carcinoma. PMID:35728869
Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2. PMID:35727845
Genome-wide mapping of somatic mutation rates uncovers drivers of cancer. PMID:35726091
A comprehensive bioinformatics analysis to identify potential prognostic biomarkers among CC and CXC chemokines in breast cancer. PMID:35725915
Promising prognostic value of Transglutaminase type 2 and its correlation with tumor-infiltrating immune cells in skin cutaneous melanoma. PMID:35725560
Single Circulating-Tumor-Cell-Targeted Sequencing to Identify Somatic Variants in Liquid Biopsies in Non-Small-Cell Lung Cancer Patients. PMID:35723337
Integrated Analysis of ECT2 and COL17A1 as Potential Biomarkers for Pancreatic Cancer. PMID:35722628
Mechanisms of SARS-CoV-2 and Male Infertility: Could Connexin and Pannexin Play a Role? PMID:35721552
CENP-A Regulation and Cancer. PMID:35721491
Functions of three ubiquitin-conjugating enzyme 2 genes in hepatocellular carcinoma diagnosis and prognosis. PMID:35721293
Attenuated ZHX3 expression is predictive of poor outcome for liver cancer: Indication for personalized therapy. PMID:35720472
SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma. PMID:35720314
Dual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma. PMID:35715826
Parallel and private generalized suffix tree construction and query on genomic data. PMID:35715724
MEX3A promotes the malignant progression of ovarian cancer by regulating intron retention in TIMELESS. PMID:35715407
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma. PMID:35712470
Differential Expression of Genes Regulating Store-operated Calcium Entry in Conjunction With Mitochondrial Dynamics as Potential Biomarkers for Cancer: A Single-Cell RNA Analysis. PMID:35711942
Discoidin Domain Receptor 2 Expression as Worse Prognostic Marker in Invasive Breast Cancer. PMID:35711892
Iron commensalism of mesenchymal glioblastoma promotes ferroptosis susceptibility upon dopamine treatment. PMID:35710828
Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer. PMID:35710704
Smurf2 inhibition enhances chemotherapy and radiation sensitivity in non-small-cell lung cancer. PMID:35710591
eIF6 as a Promising Diagnostic and Prognostic Biomarker for Poorer Survival of Cutaneous Melanoma. PMID:35707354
Protein Kinase C Epsilon Overexpression Is Associated With Poor Patient Outcomes in AML and Promotes Daunorubicin Resistance Through p-Glycoprotein-Mediated Drug Efflux. PMID:35707351
Identification of hub genes associated with bladder cancer using bioinformatic analyses. PMID:35706790
An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors. PMID:35705641
Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer. PMID:35705314
The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma. PMID:35703534
Comprehensive bioinformatics analysis of susceptibility genes for developmental dysplasia of the hip. PMID:35702583
Founder BRCA1 mutations in Nepalese population. PMID:35698740
EGFL7 expression profile in IDH-wildtype glioblastomas is associated with poor patient outcome. PMID:35698739
Advances in the systemic treatment of therapeutic approaches in biliary tract cancer. PMID:35696747
Multi-Omics Analysis of MCM2 as a Promising Biomarker in Pan-Cancer. PMID:35693940
Bioinformatic Analysis Identifying PSMB 1/2/3/4/6/8/9/10 as Prognostic Indicators in Clear Cell Renal Cell Carcinoma. PMID:35693739
Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients. PMID:35693094
Gastric cancer with enhanced apical junction pathway has increased metastatic potential and worse clinical outcomes. PMID:35693068
Genomic Validation of Endometrial Cancer Patient-Derived Xenograft Models as a Preclinical Tool. PMID:35682944
No Time to Die: How Kidney Cancer Evades Cell Death. PMID:35682876
SCAMP3 Regulates EGFR and Promotes Proliferation and Migration of Triple-Negative Breast Cancer Cells through the Modulation of AKT, ERK, and STAT3 Signaling Pathways. PMID:35681787
Prediction of Adrenocortical Carcinoma Relapse and Prognosis with a Set of Novel Multigene Panels. PMID:35681785
Targeted Therapy for Adrenocortical Carcinoma: A Genomic-Based Search for Available and Emerging Options. PMID:35681700
A Histone Deacetylase Inhibitor Induces Acetyl-CoA Depletion Leading to Lethal Metabolic Stress in RAS-Pathway Activated Cells. PMID:35681624
Model Cell Lines and Tissues of Different HGSOC Subtypes Differ in Local Estrogen Biosynthesis. PMID:35681563
Robustness of the Autophagy Pathway to Somatic Copy Number Losses. PMID:35681458
GNOSIS: an R Shiny app supporting cancer genomics survival analysis with cBioPortal. PMID:35677713
Clinical Relevance of Estrogen Reactivity in the Breast Cancer Microenvironment. PMID:35677163
Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant. PMID:35676284
Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation. PMID:35672316
Identification of the Putative Tumor Suppressor Characteristics of FAM107A via Pan-Cancer Analysis. PMID:35669436
A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma. PMID:35668194
Quantifying concordant genetic effects of de novo mutations on multiple disorders. PMID:35666111
Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Squamous Cell Carcinomas Identifies KMT2C as a Potential Tumor Suppressor. PMID:35664801
Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression. PMID:35664705
MCM10 is a Prognostic Biomarker and Correlated With Immune Checkpoints in Ovarian Cancer. PMID:35664337
Genetic and Epigenetic Mechanisms Deregulate the CRL2pVHL Complex in Hepatocellular Carcinoma. PMID:35664333
5-HT2B-mediated serotonin activation in enterocytes suppresses colitis-associated cancer initiation and promotes cancer progression. PMID:35664068
Hypoxia-regulated carbonic anhydrase IX (CAIX) protein is an independent prognostic indicator in triple negative breast cancer. PMID:35659359
Integrated proteogenomic characterization of urothelial carcinoma of the bladder. PMID:35659036
An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for Apc mutation-driven intestinal tumorigenesis. PMID:35658010
A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of MEK1/2 Inhibitors in NRAS Mutant Melanoma. PMID:35657206
The evolving landscape of prostate cancer somatic mutations. PMID:35657155
Prognostic and Immunological Role of PPP1R14A as a Pan-Cancer Analysis Candidate. PMID:35656324
DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD. PMID:35655269
Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers. PMID:35654828
Immune landscape of a genetically engineered murine model of glioma compared with human glioma. PMID:35653194
Pan-Cancer Analysis of the Oncogenic and Immunological Role of RCN3: A Potential Biomarker for Prognosis and Immunotherapy. PMID:35651805
Identification of an Inflammatory Response-Related Gene Signature to Predict Survival and Immune Status in Glioma Patients. PMID:35647198
Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer. PMID:35646860
Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis. PMID:35646543
S100A8 as a Promising Biomarker and Oncogenic Immune Protein in the Tumor Microenvironment: An Integrative Pancancer Analysis. PMID:35646116
YOD1 serves as a potential prognostic biomarker for pancreatic cancer. PMID:35642058
Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer. PMID:35641987
Mucinous Histology Is Associated with Resistance to Anti-EGFR Therapy in Patients with Left-Sided RAS/BRAF Wild-Type Metastatic Colorectal Cancer. PMID:35641204
UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer. PMID:35637955
Disclosing Potential Key Genes, Therapeutic Targets and Agents for Non-Small Cell Lung Cancer: Evidence from Integrative Bioinformatics Analysis. PMID:35632527
IL-13Rα2 Status Predicts GB-13 (IL13.E13K-PE4E) Efficacy in High-Grade Glioma. PMID:35631512
Validation of a Novel Three-Dimensional (3D Fusion) Gross Sampling Protocol for Clear Cell Renal Cell Carcinoma to Overcome Intratumoral Heterogeneity: The Meet-Uro 18 Study. PMID:35629151
Correlation of Immunological and Molecular Profiles with Response to Crizotinib in Alveolar Soft Part Sarcoma: An Exploratory Study Related to the EORTC 90101 "CREATE" Trial. PMID:35628499
Involvement of ORAI1/SOCE in Human AML Cell Lines and Primary Cells According to ABCB1 Activity, LSC Compartment and Potential Resistance to Ara-C Exposure. PMID:35628366
Correlation of NTRK1 Downregulation with Low Levels of Tumor-Infiltrating Immune Cells and Poor Prognosis of Prostate Cancer Revealed by Gene Network Analysis. PMID:35627227
MICAL1 Monooxygenase in Autosomal Dominant Lateral Temporal Epilepsy: Role in Cytoskeletal Regulation and Relation to Cancer. PMID:35627100
Multi-Omics Analyses to Identify FCGBP as a Potential Predictor in Head and Neck Squamous Cell Carcinoma. PMID:35626334
Viral and Genomic Drivers of Squamous Cell Neoplasms Arising in the Lacrimal Drainage System. PMID:35626161
RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk. PMID:35626096
Using GPCRs as Molecular Beacons to Target Ovarian Cancer with Nanomedicines. PMID:35625966
Making Invisible RNA Visible: Discriminative Sequencing Methods for RNA Molecules with Specific Terminal Formations. PMID:35625540
Clinical significance and correlation of PD-L1, B7-H3, B7-H4, and TILs in pancreatic cancer. PMID:35624419
Impact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival. PMID:35624283
Histologic and Genotypic Characterization of Lung Cancer in the Inuit Population of the Eastern Canadian Arctic. PMID:35621648
Tanshinone IIA protects against chronic obstructive pulmonary disease via exosome‑shuttled miR‑486‑5p. PMID:35621142
Genetic changes associated with relapse in favorable histology Wilms tumor: A Children's Oncology Group AREN03B2 study. PMID:35617957
Comprehensive Analysis of Prognostic and immune infiltrates for FOXPs Transcription Factors in Human Breast Cancer. PMID:35614183
The impact of ALDH7A1 variants in oral cancer development and prognosis. PMID:35613852
ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1. PMID:35613620
SPINDOC is Highly Expressed in Pan-Cancer Samples and Can Promote the Proliferation, Invasion and Migration of Hepatocellular Carcinoma Cells by Activating Wnt/β-Catenin Signaling Pathway. PMID:35611367
High expression of SLC20A1 is less effective for endocrine therapy and predicts late recurrence in ER-positive breast cancer. PMID:35605014
SOCS3 Acts as an Onco-immunological Biomarker With Value in Assessing the Tumor Microenvironment, Pathological Staging, Histological Subtypes, Therapeutic Effect, and Prognoses of Several Types of Cancer. PMID:35600392
Worldwide Prevalence and Clinical Characteristics of RAS Mutations in Head and Neck Cancer: A Systematic Review and Meta-Analysis. PMID:35600380
NUF2 Is a Potential Immunological and Prognostic Marker for Non-Small-Cell Lung Cancer. PMID:35600043
Cancer genomic profiling identified dihydropyrimidine dehydrogenase deficiency in bladder cancer promotes sensitivity to gemcitabine. PMID:35595780
Alarm Signal S100-Related Signature Is Correlated with Tumor Microenvironment and Predicts Prognosis in Glioma. PMID:35592707
Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells. PMID:35589724
TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signalling. PMID:35589707
Systematic Analysis of E2F Expression and Its Relation in Colorectal Cancer Prognosis. PMID:35585998
Tumor and Constitutional Sequencing for Neurofibromatosis Type 1. PMID:35584348
Non-enzymatic function of WRN RECQL helicase regulates removal of topoisomerase-I-DNA covalent complexes and triggers NF-κB signaling in cancer. PMID:35582959
PWWP2B promotes DNA end resection and homologous recombination. PMID:35582821
RET kinase alterations in targeted cancer therapy. PMID:35582449
Teaching an old dog new tricks: reactivated developmental signaling pathways regulate ABCB1 and chemoresistance in cancer. PMID:35582031
Mutational landscape of normal epithelial cells in Lynch Syndrome patients. PMID:35581206
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF. PMID:35580987
Transcriptional ITPR3 as potential targets and biomarkers for human pancreatic cancer. PMID:35580861
Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer. PMID:35579943
DPYSL2 interacts with JAK1 to mediate breast cancer cell migration. PMID:35575798
A Novel TAF-Related Signature Based on ECM Remodeling Genes Predicts Glioma Prognosis. PMID:35574375
Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation. PMID:35574218
MethylMasteR: A Comparison and Customization of Methylation-Based Copy Number Variation Calling Software in Cancers Harboring Large Scale Chromosomal Deletions. PMID:35573871
GABRP is a potential prognostic biomarker and correlated with immune infiltration and tumor microenvironment in pancreatic cancer. PMID:35571651
Identification of Novel Prognostic Biomarkers Relevant to Immune Infiltration in Lung Adenocarcinoma. PMID:35571056
Integrative analysis identifies CXCL11 as an immune-related prognostic biomarker correlated with cell proliferation and immune infiltration in multiple myeloma microenvironment. PMID:35568859
A bioinformatic analysis of WFDC2 (HE4) expression in high grade serous ovarian cancer reveals tumor-specific changes in metabolic and extracellular matrix gene expression. PMID:35568777
Cell line models for drug discovery in PIK3CA-mutated colorectal cancers. PMID:35568775
The E3 Ubiquitin Ligase Fbxo4 Functions as a Tumor Suppressor: Its Biological Importance and Therapeutic Perspectives. PMID:35565262
Patient-Derived Bladder Cancer Organoid Models in Tumor Biology and Drug Testing: A Systematic Review. PMID:35565191
Updated Functional Roles of NAMPT in Carcinogenesis and Therapeutic Niches. PMID:35565188
Prognostic and Immunotherapeutic Roles of KRAS in Pan-Cancer. PMID:35563733
The Long Non-Coding RNA HOXA-AS2 Promotes Proliferation of Glioma Stem Cells and Modulates Their Inflammation Pathway Mainly through Post-Transcriptional Regulation. PMID:35563134
Identification of HGD and GSTZ1 as Biomarkers Involved Metabolic Reprogramming in Kidney Renal Clear Cell Carcinoma. PMID:35562974
Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma. PMID:35562868
Integrated computational analysis reveals HOX genes cluster as oncogenic drivers in head and neck squamous cell carcinoma. PMID:35562533
SNAT7 regulates mTORC1 via macropinocytosis. PMID:35561222
Assessing the Potential Prognostic and Immunological Role of TK1 in Prostate Cancer. PMID:35559045
A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple Tumors. PMID:35559034
Retracted Article: Long non-coding RNA KCNQ1OT1 promotes osteosarcoma progression by increasing β-catenin activity. PMID:35558611
A Community-Driven, Openly Accessible Molecular Pathway Integrating Knowledge on Malignant Pleural Mesothelioma. PMID:35558518
Multi-Omics Analysis of the Prognosis and Biological Function for TRPV Channel Family in Clear Cell Renal Cell Carcinoma. PMID:35558077
Identification of a novel autophagy-related prognostic signature and small molecule drugs for glioblastoma by bioinformatics. PMID:35550147
CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies. PMID:35550030
Identification of Neoantigens and Construction of Immune Subtypes in Prostate Adenocarcinoma. PMID:35547260
FMRP ligand circZNF609 destabilizes RAC1 mRNA to reduce metastasis in acral melanoma and cutaneous melanoma. PMID:35534866
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. PMID:35534777
Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. PMID:35533575
The Role of CTNNB1 in Endometrial Cancer. PMID:35531470
Mining the prognostic significance and immune infiltration of STAT family members in human breast cancer by bioinformatics analysis. PMID:35531108
ZAP70 Activation Compensates for Loss of Class IA PI3K Isoforms Through Activation of the JAK-STAT3 Pathway. PMID:35530641
The interaction of p53 and DNA repair gene mutations and their impact on tumor mutation burden and immune response in human malignancies. PMID:35530277
Low HECTD1 mRNA expression is associated with poor prognosis and may be correlated with increased mitochondrial respiratory function in breast cancer. PMID:35530276
How often is each gene mutated within the cancer patient population? PMID:35529901
Integrated proteomic analysis of low-grade gliomas reveals contributions of 1p-19q co-deletion to oligodendroglioma. PMID:35526077
Prognostic value and immune characteristics of RUNX gene family in human cancers: a pan-cancer analysis. PMID:35522574
Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration. PMID:35521520
The Apoptotic Resistance of BRCA1-Deficient Ovarian Cancer Cells is Mediated by cAMP. PMID:35517499
Pan-cancer analysis reveals RIPK2 predicts prognosis and promotes immune therapy resistance via triggering cytotoxic T lymphocytes dysfunction. PMID:35508972
Survival-related genes are diversified across cancers but generally enriched in cancer hallmark pathways. PMID:35508961
One-step nucleic acid amplification for intraoperative diagnosis of lymph node metastasis in lung cancer patients: a single-center prospective study. PMID:35508484
Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages. PMID:35508466
BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity. PMID:35507536
VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells. PMID:35505422
Preliminary study on the role of the C5orf46 gene in renal cancer. PMID:35504177
Targeting SHP2 phosphatase in hematological malignancies. PMID:35503226
Essential m6A Methylation Regulator HNRNPC Serves as a Targetable Biomarker for Papillary Renal Cell Carcinoma. PMID:35502201
The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression. PMID:35501464
Olfactory Receptor OR2H1 Is an Effective Target for CAR T Cells in Human Epithelial Tumors. PMID:35499393
Identifying novel SMYD3 interactors on the trail of cancer hallmarks. PMID:35495117
Anchored Multiplex PCR Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA. PMID:35494035
TIM-3 Expression Level on AML Blasts Correlates With Presence of Core Binding Factor Translocations Rather Than Clinical Outcomes. PMID:35494006
Inhibiting 3βHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer. PMID:35492874
Increased expression of RUNX3 inhibits normal human myeloid development. PMID:35490198
Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer. PMID:35488350
Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response. PMID:35488273
Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors. PMID:35484114
Identification of IMPA2 as the hub gene associated with colorectal cancer and liver metastasis by integrated bioinformatics analysis. PMID:35483170
Functional network analysis of p85 and PI3K as potential gene targets and mechanism of oleanolic acid in overcoming breast cancer resistance to tamoxifen. PMID:35482141
ToPP: Tumor online prognostic analysis platform for prognostic feature selection and clinical patient subgroup selection. PMID:35479398
DNA Polymerase Delta 1 Catalytic Subunit (POLD1) as a Prognostic Factor in Clear Cell Renal Cell Carcinoma Patients. PMID:35478106
NSC305787, a pharmacological ezrin inhibitor, exhibits antineoplastic activity in pancreatic cancer cells. PMID:35477813
Structure of human chromatin-remodelling PBAF complex bound to a nucleosome. PMID:35477757
PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy. PMID:35477555
ETS transcription factor ELF3 (ESE-1) is a cell cycle regulator in benign and malignant prostate. PMID:35472129
Role of ANO1 in tumors and tumor immunity. PMID:35471604
Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows. PMID:35468810
Comprehensive analysis of the expression, prognosis, and immune infiltrates for CHDs in human lung cancer. PMID:35467222
Role of the Mosaic Cisternal Maturation Machinery in Glycan Synthesis and Oncogenesis. PMID:35465326
Identification and Validation of Chromobox Family Members as Potential Prognostic Biomarkers and Therapeutic Targets for Human Esophageal Cancer. PMID:35464847
Construction of a Two-Gene Immunogenomic-Related Prognostic Signature in Lung Squamous Cell Carcinoma. PMID:35463955
Lapatinib Suppresses HER2-Overexpressed Cholangiocarcinoma and Overcomes ABCB1- Mediated Gemcitabine Chemoresistance. PMID:35463361
In the Tumor Microenvironment, ETS1 Is an Oncogenic Immune Protein: An Integrative Pancancer Analysis. PMID:35463077
Identification of a Four-Gene Metabolic Signature to Evaluate the Prognosis of Colon Adenocarcinoma Patients. PMID:35462848
Blood-Based Next-Generation Sequencing in Adrenocortical Carcinoma. PMID:35462410
Characterization of transcriptome diversity and in vitro behavior of primary human high-risk breast cells. PMID:35459280
Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer. PMID:35456049
Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia. PMID:35454946
A Bioinformatics Evaluation of the Role of Dual-Specificity Tyrosine-Regulated Kinases in Colorectal Cancer. PMID:35454940
Combined Alcohol Exposure and KRAS Mutation in Human Pancreatic Ductal Epithelial Cells Induces Proliferation and Alters Subtype Signatures Determined by Multi-Omics Analysis. PMID:35454872
The Purinergic Landscape of Non-Small Cell Lung Cancer. PMID:35454832
Comprehensive Analysis Identifies Ameloblastin-Related Competitive Endogenous RNA as a Prognostic Biomarker for Testicular Germ Cell Tumour. PMID:35454778
Prostanoid Signaling in Cancers: Expression and Regulation Patterns of Enzymes and Receptors. PMID:35453789
Extracellular Vesicles Derived from SIPA1high Breast Cancer Cells Enhance Macrophage Infiltration and Cancer Metastasis through Myosin-9. PMID:35453742
Integrated In Silico Analyses Identify PUF60 and SF3A3 as New Spliceosome-Related Breast Cancer RNA-Binding Proteins. PMID:35453681
BRD4 Targets the KEAP1-Nrf2-G6PD Axis and Suppresses Redox Metabolism in Small Cell Lung Cancer. PMID:35453346
Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity. PMID:35449156
Immunogenic Cell Death-Relevant Damage-Associated Molecular Patterns and Sensing Receptors in Triple-Negative Breast Cancer Molecular Subtypes and Implications for Immunotherapy. PMID:35444934
Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Gliomas. PMID:35444654
TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer. PMID:35444240
Evaluation of a seven gene mutational profile as a prognostic factor in a population-based study of clear cell renal cell carcinoma. PMID:35444164
GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers. PMID:35440675
Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts. PMID:35440124
Ubiquitylation of unphosphorylated c-myc by novel E3 ligase SCFFbxl8. PMID:35438057
Co-expression patterns explain how a basic transcriptional role for MYC modulates Wnt and MAPK pathways in colon and lung adenocarcinomas. PMID:35438040
Cross-Platform in-silico Analyses Exploring Tumor Immune Microenvironment with Prognostic Value in Triple-Negative Breast Cancer. PMID:35437353
Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. PMID:35437317
PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer. PMID:35437307
Comprehensive Analysis on Prognosis and Immune Infiltration of Lysyl Oxidase Family Members in Pancreatic Adenocarcinoma With Experimental Verification. PMID:35433829
Up-to-Date Pathologic Classification and Molecular Characteristics of Intrahepatic Cholangiocarcinoma. PMID:35433771
The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients. PMID:35433488
The Prognostic Value and Immune Infiltration of USP10 in Pan-Cancer: A Potential Therapeutic Target. PMID:35433424
Identification and validation of EMT-immune-related prognostic biomarkers CDKN2A, CMTM8 and ILK in colon cancer. PMID:35429970
Identification of Novel Genes and Associated Drugs in Cervical Cancer by Bioinformatics Methods. PMID:35428744
Pan‑cancer analyses reveal the regulation and clinical outcome association of PCLAF in human tumors. PMID:35425993
BAP1-Related ceRNA (NEAT1/miR-10a-5p/SERPINE1) Promotes Proliferation and Migration of Kidney Cancer Cells. PMID:35425712
Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome. PMID:35422502
SLC1A5 Prefers to Play as an Accomplice Rather Than an Opponent in Pancreatic Adenocarcinoma. PMID:35419359
Targeting Epigenetic Regulatory Enzymes for Cancer Therapeutics: Novel Small-Molecule Epidrug Development. PMID:35419278
Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology. PMID:35418942
The Potential Role of Genomic Signature in Stage II Relapsed Colorectal Cancer (CRC) Patients: A Mono-Institutional Study. PMID:35418781
The kinesin KIF20A promotes progression to castration-resistant prostate cancer through autocrine activation of the androgen receptor. PMID:35418689
A pan-cancer analysis of GINS complex subunit 4 to identify its potential role as a biomarker in multiple human cancers. PMID:35411239
Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism. PMID:35411077
EGFR Mutations in Head and Neck Squamous Cell Carcinoma. PMID:35409179
Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma. PMID:35409173
BRCA1/2 Serves as a Biomarker for Poor Prognosis in Breast Carcinoma. PMID:35409110
High Risk-Human Papillomavirus in HNSCC: Present and Future Challenges for Epigenetic Therapies. PMID:35408843
RNA Editing in Glioma as a Sexually Dimorphic Prognostic Factor That Affects mRNA Abundance in Fatty Acid Metabolism and Inflammation Pathways. PMID:35406793
Genetic Clonality as the Hallmark Driving Evolution of Non-Small Cell Lung Cancer. PMID:35406585
TIA1 Loss Exacerbates Fatty Liver Disease but Exerts a Dual Role in Hepatocarcinogenesis. PMID:35406476
CRABP1 in Non-Canonical Activities of Retinoic Acid in Health and Diseases. PMID:35406141
Regulation of growth, invasion and metabolism of breast ductal carcinoma through CCL2/CCR2 signaling interactions with MET receptor tyrosine kinases. PMID:35405500
Integrated bioinformatic pipeline using whole-exome and RNAseq data to identify germline variants correlated with cancer. PMID:35403010
DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination. PMID:35402838
PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? PMID:35402264
Proteomic-Based Machine Learning Analysis Reveals PYGB as a Novel Immunohistochemical Biomarker to Distinguish Inverted Urothelial Papilloma From Low-Grade Papillary Urothelial Carcinoma With Inverted Growth. PMID:35402263
Urine- and Blood-Based Molecular Profiling of Human Prostate Cancer. PMID:35402245
ZNF143 Expression is Associated with COPD and Tumor Microenvironment in Non-Small Cell Lung Cancer. PMID:35400998
Clinicopathologic and molecular characteristics of EGFR-mutant lung adenocarcinomas that transform to small cell lung cancer after TKI therapy. PMID:35399568
The downregulation of fibrinogen-like protein 1 inhibits the proliferation of lung adenocarcinoma via regulating MYC-target genes. PMID:35399566
Development of Tumor Mutation Burden-Related Prognostic Model and Novel Biomarker Identification in Stomach Adenocarcinoma. PMID:35399509
Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors. PMID:35395865
TET1 mutations as a predictive biomarker for immune checkpoint inhibitors in colon adenocarcinoma. PMID:35395805
Construction of Bone Metastasis-Specific Regulation Network Based on Prognostic Stemness-Related Signatures in Prostate Cancer. PMID:35392496
Mammaglobin, GATA-binding protein 3 (GATA3), and epithelial growth factor receptor (EGFR) expression in different breast cancer subtypes and their clinical significance. PMID:35388661
CRIA: An Interactive Gene Selection Algorithm for Cancers Prediction Based on Copy Number Variations. PMID:35386679
The Valuable Role of ARMC1 in Invasive Breast Cancer as a Novel Biomarker. PMID:35378785
The Role of the TP53 Pathway in Predicting Response to Neoadjuvant Therapy in Esophageal Adenocarcinoma. PMID:35377946
Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors. PMID:35373300
Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention. PMID:35373279
Comprehensive Analysis of SMC Gene Family Prognostic Value and Immune Infiltration in Patients With Pancreatic Adenocarcinoma. PMID:35372377
The AlkB Family: Potential Prognostic Biomarkers and Therapeutic Targets in Glioblastoma. PMID:35371987
Prognostic Values and Underlying Regulatory Network of Cohesin Subunits in Esophageal Carcinoma. PMID:35371307
Expression and Regulation Network of HDAC3 in Acute Myeloid Leukemia and the Implication for Targeted Therapy Based on Multidataset Data Mining. PMID:35371279
The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells. PMID:35371049
Cleavage Stimulation Factor Subunit 2: Function Across Cancers and Potential Target for Chemotherapeutic Drugs. PMID:35370655
CEMIP as a potential biomarker and therapeutic target for breast cancer patients. PMID:35370456
Circulating Tumor Cell-Free DNA Genes as Prognostic Gene Signature for Platinum Resistant Ovarian Cancer Diagnosis. PMID:35370397
Retinoblastoma Protein Paralogs and Tumor Suppression. PMID:35368709
One Ferroptosis-Related Gene-Pair Signature Serves as an Original Prognostic Biomarker in Lung Adenocarcinoma. PMID:35368652
cSurvival: a web resource for biomarker interactions in cancer outcomes and in cell lines. PMID:35368077
Mutant p53: it's not all one and the same. PMID:35361963
USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy. PMID:35361799
New Insights Into PTBP3 in Human Cancers: Immune Cell Infiltration, TMB, MSI, PDCD1 and m6A Markers. PMID:35359851
Estrogen-Related Receptors Gene Expression and Copy Number Alteration Association With the Clinicopathologic Characteristics of Breast Cancer. PMID:35359609
Upregulation of Yin-Yang-1 Associates with Proliferation and Glutamine Metabolism in Esophageal Carcinoma. PMID:35359580
Comprehensive Analysis of the Differential Expression and Prognostic Value of Histone Deacetylases in Glioma. PMID:35359455
A Pan-Cancer Bioinformatic Analysis of RAD51 Regarding the Values for Diagnosis, Prognosis, and Therapeutic Prediction. PMID:35359409
Single-Cell RNA Sequencing Revealed a 3-Gene Panel Predicted the Diagnosis and Prognosis of Thyroid Papillary Carcinoma and Associated With Tumor Immune Microenvironment. PMID:35359404
Ultrasensitive profiling of UV-induced mutations identifies thousands of subclinical facial tumors in tuberous sclerosis complex. PMID:35358092
PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer. PMID:35357905
BCL6 and the Notch pathway: a signaling axis leading to a novel druggable biotarget in triple negative breast cancer. PMID:35357654
OmicsView: Omics data analysis through interactive visual analytics. PMID:35356547
SNRPD1/E/F/G Serve as Potential Prognostic Biomarkers in Lung Adenocarcinoma. PMID:35356432
Anatomic position determines oncogenic specificity in melanoma. PMID:35355015
KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis. PMID:35354467
Searching of Clinical Trials Made Easier in cBioPortal Using Patients' Genetic and Clinical Profiles. PMID:35354211
Bioinformatics Analysis Combined With Experiments Predicts PUDP as a Potential Prognostic Biomarker for Hepatocellular Carcinoma Through Its Interaction With Tumor Microenvironment. PMID:35350563
MCL-1 is a clinically targetable vulnerability in breast cancer. PMID:35349392
Multi-omics analyses provide novel biological insights to distinguish lobular ductal types of invasive breast cancers. PMID:35348974
Clinical significance of FBXW7 loss of function in human cancers. PMID:35346215
Prognostic significance of SNCA and its methylation in bladder cancer. PMID:35346107
Aberrant SKP1 Expression: Diverse Mechanisms Impacting Genome and Chromosome Stability. PMID:35345853
A systematic pan-cancer study demonstrates the oncogenic function of heterogeneous nuclear ribonucleoprotein C. PMID:35344508
Four m6A RNA Methylation Gene Signatures and Their Prognostic Values in Lung Adenocarcinoma. PMID:35343834
Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression. PMID:35340765
Glycoprotein hormone α-subunit promotes cell proliferation and tumorigenesis in breast cancer. PMID:35340558
Upregulated phospholipase D2 expression and activity is related to the metastatic properties of melanoma. PMID:35340556
Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers. PMID:35338148
Significant Roles of Notch O-Glycosylation in Cancer. PMID:35335147
Tumor-associated macrophages related signature in glioma. PMID:35332109
Pan-cancer analysis identifies BIRC5 as a prognostic biomarker. PMID:35331169
High Mutation Burden in ER-Positive/HER2-Negative/Luminal Breast Cancers. PMID:35329928
Oncogenic Pathways in Neurodegenerative Diseases. PMID:35328644
LPPR5 Expression in Glioma Affects Growth, Vascular Architecture, and Sunitinib Resistance. PMID:35328529
Gene Expression Analysis of Biphasic Pleural Mesothelioma: New Potential Diagnostic and Prognostic Markers. PMID:35328227
p53 Immunohistochemistry and Mutation Types Mismatching in High-Grade Serous Ovarian Cancer. PMID:35328131
Visualization of the Effect of Assay Size on the Error Profile of Tumor Mutational Burden Measurement. PMID:35327986
Impact of miR-1/miR-133 Clustered miRNAs: PFN2 Facilitates Malignant Phenotypes in Head and Neck Squamous Cell Carcinoma. PMID:35327465
At the Intersection of Cardiology and Oncology: TGFβ as a Clinically Translatable Therapy for TNBC Treatment and as a Major Regulator of Post-Chemotherapy Cardiomyopathy. PMID:35326728
Toward Targeted Therapies in Oesophageal Cancers: An Overview. PMID:35326673
Transcriptional Profiling of Malignant Melanoma Reveals Novel and Potentially Targetable Gene Fusions. PMID:35326655
Circulating Tumor DNA Profiling of a Diffuse Large B Cell Lymphoma Patient with Secondary Acute Myeloid Leukemia. PMID:35326522
SWI/SNF Antagonism of PRC2 Mediates Estrogen-Induced Progesterone Receptor Expression. PMID:35326450
Redox-Related Proteins in Melanoma Progression. PMID:35326089
Bioinformatics Analysis and Identification of Potential Genes Associated with Pathogenesis and Prognosis of Gastric Cancer. PMID:35325407
Urothelial Bladder Carcinomas with High Tumor Mutation Burden Have a Better Prognosis and Targetable Molecular Defects beyond Immunotherapies. PMID:35323317
SWI/SNF Chromatin Remodeling Enzymes in Melanoma. PMID:35323214
Chemokine CCL17 Affects Local Immune Infiltration Characteristics and Early Prognosis Value of Lung Adenocarcinoma. PMID:35321241
Prognostic and biological role of the N-Myc downstream-regulated gene family in hepatocellular carcinoma. PMID:35321174
Comprehensive bioinformatic analysis reveals oncogenic role of H2A.Z isoforms in cervical cancer progression. PMID:35317119
Reductive TCA cycle catalyzed by wild-type IDH2 promotes acute myeloid leukemia and is a metabolic vulnerability for potential targeted therapy. PMID:35313945
Heat Shock Proteins and HSF1 in Cancer. PMID:35311075
The Pan-Cancer Crosstalk Between the EFNA Family and Tumor Microenvironment for Prognosis and Immunotherapy of Gastric Cancer. PMID:35309935
Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium. PMID:35309931
Construction of a Pyroptosis-Related Signature for Prognostic Prediction and Characterization of Immune Microenvironment in Acute Myelogenous Leukemia. PMID:35308573
Evaluation of Targeted Next-Generation Sequencing for the Management of Patients Diagnosed with a Cancer of Unknown Primary. PMID:35305098
The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers. PMID:35304457
p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases. PMID:35304445
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia. PMID:35301220
Multidimensional Analysis of CHMP Family Members in Hepatocellular Carcinoma. PMID:35300135
Identification of IL20RB as a Novel Prognostic and Therapeutic Biomarker in Clear Cell Renal Cell Carcinoma. PMID:35299868
Roles of Pyroptosis-Related Gene Signature in Prediction of Endometrial Cancer Outcomes. PMID:35299842
HER2 expression, copy number variation and survival outcomes in HER2-low non-metastatic breast cancer: an international multicentre cohort study and TCGA-METABRIC analysis. PMID:35296300
DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation. PMID:35296003
The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes. PMID:35294876
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. PMID:35294260
Aberrations in SMAD family of genes among HNSCC patients. PMID:35291342
vWCluster: Vector-valued optimal transport for network based clustering using multi-omics data in breast cancer. PMID:35286348
Evaluation of the Prognostic Relevance of Differential Claudin Gene Expression Highlights Claudin-4 as Being Suppressed by TGFβ1 Inhibitor in Colorectal Cancer. PMID:35281827
Dishevelled-Associated Activator of Morphogenesis 2 (DAAM2) Predicts the Immuno-Hot Phenotype in Pancreatic Adenocarcinoma. PMID:35281277
Anaplastic thyroid cancer: genome-based search for new targeted therapy options. PMID:35275096
Pan-Cancer Transcriptome and Immune Infiltration Analyses Reveal the Oncogenic Role of Far Upstream Element-Binding Protein 1 (FUBP1). PMID:35274005
Comprehensive Analyses of the Immunological and Prognostic Roles of an IQGAP3AR/let-7c-5p/IQGAP3 Axis in Different Types of Human Cancer. PMID:35274003
A saturation-mutagenesis analysis of the interplay between stability and activation in Ras. PMID:35272765
Production and Stabilization of Specific Upregulated Long Noncoding RNA HOXD-AS2 in Glioblastomas Are Mediated by TFE3 and miR-661, Respectively. PMID:35269968
CK1 Is a Druggable Regulator of Microtubule Dynamics and Microtubule-Associated Processes. PMID:35267653
Understanding Retinoblastoma Post-Translational Regulation for the Design of Targeted Cancer Therapies. PMID:35267571
Evaluation of the Clinical Utility of Genomic Profiling to Inform Selection of Clinical Trial Therapy in Salivary Gland Cancer. PMID:35267442
Long Noncoding RNA LOC554202 Predicts a Poor Prognosis and Correlates with Immune Infiltration in Thyroid Cancer. PMID:35265169
MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization. PMID:35264604
Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas. PMID:35264242
RNA-seq and integrated network analysis reveals the hub genes and key pathway of paclitaxel inhibition on Adriamycin resistant diffuse large B cell lymphoma cells. PMID:35263200
Assessment of POLE and POLD1 mutations as prognosis and immunotherapy biomarkers for stomach adenocarcinoma. PMID:35261896
Pan-cancer analysis of osteogenesis imperfecta causing gene SERPINF1. PMID:35261846
H2AX mRNA expression reflects DNA repair, cell proliferation, metastasis, and worse survival in breast cancer. PMID:35261802
Upregulation of Cyclin B2 (CCNB2) in breast cancer contributes to the development of lymphovascular invasion. PMID:35261781
ATP13A3 facilitates polyamine transport in human pancreatic cancer cells. PMID:35260637
Polo-like kinases as potential targets and PLK2 as a novel biomarker for the prognosis of human glioblastoma. PMID:35256538
UBIAD1 and CoQ10 protect melanoma cells from lipid peroxidation-mediated cell death. PMID:35255427
Comprehensive analyses of prognostic biomarkers and immune infiltrates among histone lysine demethylases (KDMs) in hepatocellular carcinoma. PMID:35254477
Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development. PMID:35252866
CNViz: An R/Shiny Application for Interactive Copy Number Variant Visualization in Cancer. PMID:35251754
Computational simulations of identified marine-derived natural bioactive compounds as potential inhibitors of oral cancer. PMID:35251696
A single-nucleotide-polymorphism in the 5'-flanking region of MSX1 gene as a predictive marker candidate for platinum-based therapy of esophageal carcinoma. PMID:35251318
Comprehensive Analysis of HOX Family Members as Novel Diagnostic and Prognostic Markers for Hepatocellular Carcinoma. PMID:35251173
High RAD51 gene expression is associated with aggressive biology and with poor survival in breast cancer. PMID:35249172
Cellular mechanisms underlying response and resistance to CDK4/6 inhibitors in the treatment of hormone receptor-positive breast cancer. PMID:35248122
DrGA: cancer driver gene analysis in a simpler manner. PMID:35247965
RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition. PMID:35247929
Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis. PMID:35246964
Abnormal expression and the significant prognostic value of aquaporins in clear cell renal cell carcinoma. PMID:35245343
DYRK1A suppression attenuates HIF‑1α accumulation and enhances the anti‑liver cancer effects of regorafenib and sorafenib under hypoxic conditions. PMID:35244188
Pan-Cancer Analysis Predicts FOXS1 as a Key Target in Prognosis and Tumor Immunotherapy. PMID:35241932
Pan-cancer analysis of ARID family members as novel biomarkers for immune checkpoint inhibitor therapy. PMID:35239432
Gα12 and Gα13: Versatility in Physiology and Pathology. PMID:35237598
Comprehensive Analysis of Immune Implications and Prognostic Value of SPI1 in Gastric Cancer. PMID:35237521
Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin. PMID:35235808
Computational Resources for the Interpretation of Variations in Cancer. PMID:35230689
Experimental models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor. PMID:35228656
Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) expression in glioblastoma is driven by ETS1- and MYBL2-dependent transcriptional activation. PMID:35228525
Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study. PMID:35227109
Ruthenium(ii)-arene complexes as anti-metastatic agents, and related techniques. PMID:35224494
Diagnostic, Therapeutic, and Prognostic Value of the m6A Writer Complex in Hepatocellular Carcinoma. PMID:35223847
Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms. PMID:35223844
Inhibition of NEK7 Suppressed Hepatocellular Carcinoma Progression by Mediating Cancer Cell Pyroptosis. PMID:35223495
Guanylate-Binding Protein 1 as a Potential Predictor of Immunotherapy: A Pan-Cancer Analysis. PMID:35222540
A DNA-Methylation-Driven Genes Based Prognostic Signature Reveals Immune Microenvironment in Pancreatic Cancer. PMID:35222383
Therapeutic effects of TM4SF5-targeting chimeric and humanized monoclonal antibodies in hepatocellular and colon cancer models. PMID:35211652
Pan-Cancer Analysis of Microfibrillar-Associated Protein 2 (MFAP2) Based on Bioinformatics and qPCR Verification. PMID:35211173
A Review of Circulating Tumor DNA in the Diagnosis and Monitoring of Esophageal Cancer. PMID:35210388
Expression profile and prognostic values of Chromobox family members in human glioblastoma. PMID:35210369
Mutational Landscape and Actionable Target Rates on Advanced Stage Refractory Cancer Patients: A Multicenter Chilean Experience. PMID:35207683
Ki67 and LSD1 Expression in Testicular Germ Cell Tumors Is Not Associated with Patient Outcome: Investigation Using a Digital Pathology Algorithm. PMID:35207551
Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment. PMID:35205761
Global Genomic and Proteomic Analysis Identified Critical Pathways Modulated by Proto-Oncogene PELP1 in TNBC. PMID:35205680
Discoidin Domain Receptor 1 Expression in Colon Cancer: Roles and Prognosis Impact. PMID:35205677
The Role of VHL in the Development of von Hippel-Lindau Disease and Erythrocytosis. PMID:35205407
A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors. PMID:35205150
Identification of Key Proteins from the Alternative Lengthening of Telomeres-Associated Promyelocytic Leukemia Nuclear Bodies Pathway. PMID:35205052
Exploring the Wnt Pathway as a Therapeutic Target for Prostate Cancer. PMID:35204808
Vulnerability of Triple-Negative Breast Cancer to Saponin Formosanin C-Induced Ferroptosis. PMID:35204181
Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma. PMID:35203444
Normal and Neoplastic Growth Suppression by the Extended Myc Network. PMID:35203395
Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer. PMID:35201488
A Case Series of Metastatic Malignant Gastrointestinal Neuroectodermal Tumors and Comprehensive Genomic Profiling Analysis of 20 Cases. PMID:35200608
Identification of the gene expression changes and gene regulatory aspects in ELF3 mutant bladder cancer. PMID:35199247
Robust Prediction of Prognosis and Immunotherapeutic Response for Clear Cell Renal Cell Carcinoma Through Deep Learning Algorithm. PMID:35197975
Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization. PMID:35197571
Survival Genie, a web platform for survival analysis across pediatric and adult cancers. PMID:35197510
Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. PMID:35197475
PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer. PMID:35197445
IDH1/2 mutations in acute myeloid leukemia. PMID:35197370
A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer. PMID:35196489
The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization. PMID:35193494
A Comprehensive Prognostic Analysis of POLD1 in Hepatocellular Carcinoma. PMID:35189839
Comprehensive Analysis of the Prognostic and Immunological Role of PAFAH1B in Pan-Cancer. PMID:35187070
A Prognostic Model for Acute Myeloid Leukemia Based on IL-2/STAT5 Pathway-Related Genes. PMID:35186733
NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model. PMID:35186194
Adult Wilms Tumor: Genetic Evidence of Origin of a Subset of Cases From Metanephric Adenoma. PMID:35184066
New insights on familial colorectal cancer type X syndrome. PMID:35181726
Comprehensive analysis of the expression and significance of CXCLs in human diffuse large B-cell lymphoma. PMID:35181719
PIK3CA co-occurring mutations and copy-number gain in hormone receptor positive and HER2 negative breast cancer. PMID:35181669
RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer. PMID:35179959
Transcriptomic Mapping of Non-Small Cell Lung Cancer K-RAS p.G12C Mutated Tumors: Identification of Surfaceome Targets and Immunologic Correlates. PMID:35178045
Tumor stromal nicotinamide N-methyltransferase overexpression as a prognostic biomarker for poor clinical outcome in early-stage colorectal cancer. PMID:35177765
Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition. PMID:35177674
Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways. PMID:35177083
The Genomics of Colorectal Cancer in Populations with African and European Ancestry. PMID:35176763
MECOM/PRDM3 and PRDM16 Serve as Prognostic-Related Biomarkers and Are Correlated With Immune Cell Infiltration in Lung Adenocarcinoma. PMID:35174083
The Mechanism and Prognostic Value of DNA Polymerase δ Subunits in Hepatocellular Carcinoma: Implications for Precision Therapy. PMID:35173474
YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia. PMID:35170430
A gene signature consisting of ubiquitin ligases and deubiquitinating enzymes of SKP2 is associated with clinical outcome in breast cancer. PMID:35169199
Exploring ALDH2 expression and immune infiltration in HNSC and its correlation of prognosis with gender or alcohol intake. PMID:35169188
ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma. PMID:35167193
A pan-cancer analysis of molecular characteristics and oncogenic role of gasdermins. PMID:35164740
The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells. PMID:35163828
Deciphering Genetic Alterations of Taiwanese Patients with Pancreatic Adenocarcinoma through Targeted Sequencing. PMID:35163506
EVI1 Promotes the Proliferation and Invasive Properties of Human Head and Neck Squamous Cell Carcinoma Cells. PMID:35162973
p53 Promotes Cytokine Expression in Melanoma to Regulate Drug Resistance and Migration. PMID:35159215
Identification of a Gene-Expression-Based Surrogate of Genomic Instability during Oral Carcinogenesis. PMID:35159101
Dissecting TET2 Regulatory Networks in Blood Differentiation and Cancer. PMID:35159097
AKR1B1 as a Prognostic Biomarker of High-Grade Serous Ovarian Cancer. PMID:35159076
Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice. PMID:35159064
Targeting Oncogenic Pathways in the Era of Personalized Oncology: A Systemic Analysis Reveals Highly Mutated Signaling Pathways in Cancer Patients and Potential Therapeutic Targets. PMID:35158934
New Insights on the Genetics of Pheochromocytoma and Paraganglioma and Its Clinical Implications. PMID:35158861
DNA Methylome Changes of Muscle- and Neuronal-Related Processes Precede Bladder Cancer Invasiveness. PMID:35158756
ITIH5-Derived Polypeptides Covering the VIT Domain Suppress the Growth of Human Cancer Cells In Vitro. PMID:35158755
Over-Expression and Prognostic Significance of FATP5, as a New Biomarker, in Colorectal Carcinoma. PMID:35155561
It's Getting Complicated-A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy. PMID:35155432
STIL Acts as an Oncogenetic Driver in a Primary Cilia-Dependent Manner in Human Cancer. PMID:35155425
Comprehensive and Integrative Analysis of Two Novel SARS-CoV-2 Entry Associated Proteases CTSB and CTSL in Healthy Individuals and Cancer Patients. PMID:35155389
A Pan-Cancer Analysis of the Oncogenic Role of Nuclear Transport Factor 2 in Human Cancers. PMID:35155261
A New Strategy to Identify ceRNA-Based CCDC144NL-AS1/SERPINE1 Regulatory Axis as a Novel Prognostic Biomarker for Stomach Adenocarcinoma via High Throughput Transcriptome Data Mining and Computational Verification. PMID:35155200
Intestinal Stem Cell Marker ASCL2 is a Novel Prognostic Predictor in Esophageal Adenocarcinoma. PMID:35154991
The DNA damage repair landscape in Black women with breast cancer. PMID:35154416
Identification of a Novel Nomogram to Predict Progression Based on the Circadian Clock and Insights Into the Tumor Immune Microenvironment in Prostate Cancer. PMID:35154101
Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer. PMID:35153749
Genome Nexus: A Comprehensive Resource for the Annotation and Interpretation of Genomic Variants in Cancer. PMID:35148171
HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer. PMID:35144669
Cancer and COVID-19 Susceptibility and Severity: A Two-Sample Mendelian Randomization and Bioinformatic Analysis. PMID:35141230
Pan-Cancer Analyses Reveal Oncogenic Role and Prognostic Value of F-Box Only Protein 22. PMID:35141150
A platform for oncogenomic reporting and interpretation. PMID:35140225
CPNE1 is a potential prognostic biomarker, associated with immune infiltrates and promotes progression of hepatocellular carcinoma. PMID:35139863
The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders. PMID:35136038
A data management infrastructure for the integration of imaging and omics data in life sciences. PMID:35130839
Chemogenomic and bioinformatic profiling of ERdj paralogs underpins their unique roles in cancer. PMID:35129801
Prognostic Bone Metastasis-Associated Immune-Related Genes Regulated by Transcription Factors in Mesothelioma. PMID:35127947
Identification of Tumor Antigens and Design of mRNA Vaccine for Colorectal Cancer Based on the Immune Subtype. PMID:35127707
Prognostic Implication and Oncogenic Role of PNPO in Pan-Cancer. PMID:35127701
Positive predictive value of ERBB2 copy number gain by tissue or circulating tumor DNA next-generation sequencing across advanced cancers. PMID:35126865
Genetic Alteration, Prognostic and Immunological Role of Acyl-CoA Synthetase Long-Chain Family Member 4 in a Pan-Cancer Analysis. PMID:35126480
Systematic Analysis of Expression and Prognostic Values of Lysyl Oxidase Family in Gastric Cancer. PMID:35126449
When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer. PMID:35123413
Discovery through clinical sequencing in oncology. PMID:35122052
MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination. PMID:35122005
Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumor immunity. PMID:35121862
Exploiting the tumor-suppressive activity of the androgen receptor by CDK4/6 inhibition in castration-resistant prostate cancer. PMID:35121110
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients. PMID:35120664
Bioinformatics analysis of the clinical relevance of CDCA gene family in prostate cancer. PMID:35119046
Gene Expression-Based Predication of RNA Pseudouridine Modification in Tumor Microenvironment and Prognosis of Glioma Patients. PMID:35118063
COL4A family: potential prognostic biomarkers and therapeutic targets for gastric cancer. PMID:35117889
Identification of biomarkers in colon cancer based on bioinformatic analysis. PMID:35117850
Bioinformatics analysis of BUB1 expression and gene regulation network in lung adenocarcinoma. PMID:35117845
KIT/PDGFRA/KDR amplification defines a novel molecular subtype of adenoid cystic carcinoma patients who may benefit from treatment with tyrosine kinase inhibitors. PMID:35117834
GLUT1/3/4 as novel biomarkers for the prognosis of human breast cancer. PMID:35117597
Non-SMC condensin I complex subunit H (NCAPH), a regulator of cell cycle, predicts poor prognosis in lung adenocarcinoma patients: a study mainly based on TCGA and GEO database. PMID:35117357
Epithelial-mesenchymal transition classification of circulating tumor cells in lung and colon cancer patients: potential role in clinical practice. PMID:35117274
Comprehensive analysis of the NME gene family functions in breast cancer. PMID:35117245
High expression of forkhead box M1 (FOXM1) is a poor prognostic biomarker in lung adenocarcinoma. PMID:35117241
Systemic characterization of the SLC family genes reveals SLC26A6 as a novel oncogene in hepatocellular carcinoma. PMID:35116598
Bioinformatic analysis of PLOD family member expression and prognostic value in non-small cell lung cancer. PMID:35116582
PUM1 is upregulated by DNA methylation to suppress antitumor immunity and results in poor prognosis in pancreatic cancer. PMID:35116535
Low expression of AQP9 and its value in hepatocellular carcinoma. PMID:35116505
A rare multiple primary sarcomatoid carcinoma (SCA) of small intestine harboring driver gene mutations: a case report and a literature review. PMID:35116442
Expression of CDK7 correlates with molecular subtypes and predicts clinical outcomes in breast cancer. PMID:35116400
Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer. PMID:35116394
A pan-cancer analysis of the oncogenic role of Keratin 17 (KRT17) in human tumors. PMID:35116305
The role of TRIM51 as a multipurpose biomarker in melanoma. PMID:35116291
Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis. PMID:35115556
Molecular Subtyping Resource: a user-friendly tool for rapid biological discovery from transcriptional data. PMID:35112706
SPARCL1 Is a Novel Prognostic Biomarker and Correlates with Tumor Microenvironment in Colorectal Cancer. PMID:35111844
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation. PMID:35105861
Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer. PMID:35105671
The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression. PMID:35102251
A novel long non-coding RNA regulates the integrin, ITGA2 in breast cancer. PMID:35098437
Malignant solitary fibrous tumor in the central nervous system treated with surgery, radiotherapy and anlotinib: A case report. PMID:35097089
In-Silico Multi-Omics Analysis of the Functional Significance of Calmodulin 1 in Multiple Cancers. PMID:35096010
LINC00467 Is Upregulated by DNA Copy Number Amplification and Hypomethylation and Shows ceRNA Potential in Lung Adenocarcinoma. PMID:35095769
Using Optical Tweezers to Dissect Allosteric Communication Networks in Protein Kinases. PMID:35094342
The oncogenic role of treacle ribosome biogenesis factor 1 (TCOF1) in human tumors: a pan-cancer analysis. PMID:35093935
Rho GTPase gene expression and breast cancer risk: a Mendelian randomization analysis. PMID:35087170
Proteomic profiling of cisplatin-resistant and cisplatin-sensitive germ cell tumour cell lines using quantitative mass spectrometry. PMID:35084545
Evidence for shared genetic risk factors between lymphangioleiomyomatosis and pulmonary function. PMID:35083324
The Age-Specific Features and Clinical Significance of NRF2 and MAPK10 Expression in HCC Patients. PMID:35082522
Modeling Androgen Deprivation Therapy-Induced Prostate Cancer Dormancy and Its Clinical Implications. PMID:35082166
KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas. PMID:35081118
Let's talk about sex: A biological variable in immune response against melanoma. PMID:35076986
Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT. PMID:35075245
Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations. PMID:35075200
Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer. PMID:35075123
A comprehensive characterization of the transcriptome in enzalutamide resistance prostate cancer. PMID:35071476
Genomic Profiling of Chinese Cervical Cancer Patients Reveals Prevalence of DNA Damage Repair Gene Alterations and Related Hypoxia Feature. PMID:35071000
Comprehensive Analysis of Copy Number Variation, Nucleotide Mutation, and Transcription Level of PPAR Pathway-Related Genes in Endometrial Cancer. PMID:35069712
Insights Into the Prognostic Value and Immunological Role of NAAA in Pan-Cancer. PMID:35069601
Classification of bladder cancer cell lines according to regulon activity. PMID:35068946
High expression of PDZ-binding kinase is correlated with poor prognosis and immune infiltrates in hepatocellular carcinoma. PMID:35065633
Characterization of Epigenomic Alterations in HPV16+ Head and Neck Squamous Cell Carcinomas. PMID:35064062
Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma. PMID:35062934
Bioinformatics analysis of recurrent deletion regions in neuroblastoma. PMID:35059899
Prognostic Value and Immune Infiltration Analysis of Nuclear Factor Erythroid-2 Family Members in Ovarian Cancer. PMID:35059466
Histological and molecular plasticity of ALK-positive non-small-cell lung cancer under targeted therapy: a case report. PMID:35058282
EGFR Exon 20 Insertion Mutations in Sinonasal Squamous Cell Carcinoma. PMID:35053553
High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients. PMID:35053500
Increased Expression and Altered Cellular Localization of Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Are Associated with Prostate Cancer Progression. PMID:35053442
Genetic Alterations in Mitochondrial DNA Are Complementary to Nuclear DNA Mutations in Pheochromocytomas. PMID:35053433
Onco-miR-21 Promotes Stat3-Dependent Gastric Cancer Progression. PMID:35053428
Decode the Stable Cell Communications Based on Neuropeptide-Receptors Network in 36746 Tumor Cells. PMID:35052689
The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors. PMID:35049682
Downregulation of m6 A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness. PMID:35048498
The dominant TP53 hotspot mutation in IDH -mutant astrocytoma, R273C, has distinctive pathologic features and sex-specific prognostic implications. PMID:35047821
Expression of TIMPs and MMPs in Ovarian Tumors, Ascites, Ascites-Derived Cells, and Cancer Cell Lines: Characteristic Modulatory Response Before and After Chemotherapy Treatment. PMID:35047406
Comprehensive Analysis of Prognostic Value and Immune Infiltration of the NT5DC Family in Hepatocellular Carcinoma. PMID:35047040
The path to the clinic: a comprehensive review on direct KRASG12C inhibitors. PMID:35045886
Enhancing Radioiodine Incorporation in BRAF-Mutant, Radioiodine-Refractory Thyroid Cancers with Vemurafenib and the Anti-ErbB3 Monoclonal Antibody CDX-3379: Results of a Pilot Clinical Trial. PMID:35045748
Primary tumour immune response and lymph node yields in colon cancer. PMID:35043009
Primary lung cancer in women after previous breast cancer. PMID:35040941
Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer. PMID:35040374
MiR-378a inhibits glucose metabolism by suppressing GLUT1 in prostate cancer. PMID:35039635
Integration of tumour sequencing and case-control data to assess pathogenicity of RAD51C missense variants in familial breast cancer. PMID:35039523
The initial expression alterations occurring to transcription factors during the formation of breast cancer: Evidence from bioinformatics. PMID:35037412
Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover. PMID:35033184
Core promoter mutation contributes to abnormal gene expression in bladder cancer. PMID:35033028
Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomarker. PMID:35033016
The modifying enzyme Tsr3 establishes the hierarchy of Rio kinase binding in 40S ribosome assembly. PMID:35031584
Calcium selective channel TRPV6: Structure, function, and implications in health and disease. PMID:35031425
How can same-gene mutations promote both cancer and developmental disorders? PMID:35030014
Promising novel biomarkers and candidate small-molecule drugs for lung adenocarcinoma: Evidence from bioinformatics analysis of high-throughput data. PMID:35028418
HBXIP induces anoikis resistance by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis and stabilize Prdx1 in breast cancer. PMID:35027562
USP15 and USP4 facilitate lung cancer cell proliferation by regulating the alternative splicing of SRSF1. PMID:35027535
The clinicopathological and molecular characteristics of resected EGFR-mutant lung adenocarcinoma. PMID:35023616
Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma. PMID:35022408
Low RUFY3 expression level is associated with lymph node metastasis in older women with invasive breast cancer. PMID:35018543
Truncating CDKN1A mutations: an insight into the biology of urinary tract carcinomas? PMID:35018253
Galectin-8, cytokines, and the storm. PMID:35015084
Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment. PMID:35013322
Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast. PMID:35013309
Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer. PMID:35013121
PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer. PMID:35013112
Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer. PMID:35012444
Neurofibromatosis Type 1 Gene Alterations Define Specific Features of a Subset of Glioblastomas. PMID:35008787
A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members. PMID:35008511
Secretory Autophagy Forges a Therapy Resistant Microenvironment in Melanoma. PMID:35008395
FoxO3a Inhibits Tamoxifen-Resistant Breast Cancer Progression by Inducing Integrin α5 Expression. PMID:35008379
Bak and Bcl-xL Participate in Regulating Sensitivity of Solid Tumor Derived Cell Lines to Mcl-1 Inhibitors. PMID:35008345
Role of novel cancer gene SLITRK3 to activate NTRK3 in squamous cell lung cancer. PMID:35006496
Integrated bioinformatics and experiments reveal the roles and driving forces for HSF1 in colorectal cancer. PMID:35006040
High Expression of Glycolytic Genes in Clinical Glioblastoma Patients Correlates With Lower Survival. PMID:35004842
CDKN2A Deletion Leading to Hematogenous Metastasis of Human Gastric Carcinoma. PMID:35004325
The mechanism of Raf activation through dimerization. PMID:35003591
Comprehensive Analyses of the Expression, Genetic Alteration, Prognosis Significance, and Interaction Networks of m6A Regulators Across Human Cancers. PMID:35003212
Systematic Pan-Cancer Analysis of KIF23 and a Prediction Model Based on KIF23 in Clear Cell Renal Cell Carcinoma (ccRCC). PMID:35002290
oCEM: Automatic detection and analysis of overlapping co-expressed gene modules. PMID:34998362
Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights. PMID:34996497
Identifying and Validating an Acidosis-Related Signature Associated with Prognosis and Tumor Immune Infiltration Characteristics in Pancreatic Carcinoma. PMID:34993253
Identification of high protein kinase CK2α in HPV(+) oropharyngeal squamous cell carcinoma and correlation with clinical outcomes. PMID:34993017
MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling. PMID:34992146
Development and validation of the new HER2DX assay for predicting pathological response and survival outcome in early-stage HER2-positive breast cancer. PMID:34990895
Metabolite profiling reveals a connection between aldehyde dehydrogenase 1A3 and GABA metabolism in breast cancer metastasis. PMID:34989902
POU2F3 beyond thymic carcinomas: expression across the spectrum of thymomas hints to medullary differentiation in type A thymoma. PMID:34988657
Characterization of the consensus mucosal microbiome of colorectal cancer. PMID:34988460
The Identification of Prognostic and Metastatic Alternative Splicing in Skin Cutaneous Melanoma. PMID:34986671
Overexpression of the PPAR-γ protein in primary Ta/T1 non-muscle-invasive urothelial carcinoma. PMID:34984103
Retinoblastoma protein regulates carcinogen susceptibility at heterochromatic cancer driver loci. PMID:34983823
KRAS Mutations in Squamous Cell Carcinomas of the Lung. PMID:34976827
FNDC3B and BPGM Are Involved in Human Papillomavirus-Mediated Carcinogenesis of Cervical Cancer. PMID:34976823
RNA-binding protein MEX3A controls G1/S transition via regulating the RB/E2F pathway in clear cell renal cell carcinoma. PMID:34976441
rAAV-delivered PTEN therapeutics for prostate cancer. PMID:34976432
Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway. PMID:34975329
Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis. PMID:34973624
Glycogenes in Oncofetal Chondroitin Sulfate Biosynthesis are Differently Expressed and Correlated With Immune Response in Placenta and Colorectal Cancer. PMID:34966741
P4HA1, a Prognostic Biomarker that Correlates With Immune Infiltrates in Lung Adenocarcinoma and Pan-Cancer. PMID:34966739
Splicing Factor DDX23, Transcriptionally Activated by E2F1, Promotes Ovarian Cancer Progression by Regulating FOXM1. PMID:34966670
Identification of the 7-lncRNA Signature as a Prognostic Biomarker for Acute Myeloid Leukemia. PMID:34966465
High Expression of CEMIP Correlates Poor Prognosis and the Tumur Microenvironment in Breast Cancer as a Promisingly Prognostic Biomarker. PMID:34966410
ESR1 hotspot mutations in endometrial stromal sarcoma with high-grade transformation and endocrine treatment. PMID:34961764
Myosin 1b promotes migration, invasion and glycolysis in cervical cancer via ERK/HIF-1α pathway. PMID:34956471
LINC00467, Driven by Copy Number Amplification and DNA Demethylation, Is Associated with Oxidative Lipid Metabolism and Immune Infiltration in Breast Cancer. PMID:34956437
p53 Immunohistochemistry Patterns Are Surrogate Biomarkers for TP53 Mutations in Gastrointestinal Neuroendocrine Neoplasms. PMID:34956360
Genomic analyses of the metastasis-derived prostate cancer cell lines LNCaP, VCaP, and PC3-AR. PMID:34951700
KDM6 Demethylases and Their Roles in Human Cancers. PMID:34950587
High Frequency of Juxtamembrane Domain ERBB2 Mutation in Gastric Cancer. PMID:34949663
MicroRNAs Regulate Cell Cycle and Cell Death Pathways in Glioblastoma. PMID:34948346
Nuclear RNA Exosome and Pervasive Transcription: Dual Sculptors of Genome Function. PMID:34948199
Pharmacological Inhibition of Sonic Hedgehog Signaling Suppresses Tumor Development in a Murine Model of Intrahepatic Cholangiocarcinoma. PMID:34948011
µ-Crystallin Is Associated with Disease Outcome in Head and Neck Squamous Cell Carcinoma. PMID:34945802
Insights of RKIP-Derived Suppression of Prostate Cancer. PMID:34945007
Carnitine Palmitoyltransferase 1 Regulates Prostate Cancer Growth under Hypoxia. PMID:34944922
Transcription Regulation and Genome Rewiring Governing Sensitivity and Resistance to FOXM1 Inhibition in Breast Cancer. PMID:34944900
YB1 Is a Major Contributor to Health Disparities in Triple Negative Breast Cancer. PMID:34944882
Rapid Androgen-Responsive Proteome Is Involved in Prostate Cancer Progression. PMID:34944692
Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases. PMID:34944522
Exploring the Value of BRD9 as a Biomarker, Therapeutic Target and Co-Target in Prostate Cancer. PMID:34944438
Targeting Chondroitin Sulfate Reduces Invasiveness of Glioma Cells by Suppressing CD44 and Integrin β1 Expression. PMID:34944101
TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in Triple-Negative Breast Cancer. PMID:34943938
Association between Altered Oncogenic Signaling Pathways and Overall Survival of Patients with Metastatic Colorectal Cancer. PMID:34943546
Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis. PMID:34941867
Expression and Clinical Significance of Novel Long Noncoding RNA Fibroblast Growth Factor 10AS and FGF10 in Colorectal Cancer. PMID:34939760
KDM4B promotes acute myeloid leukemia associated with AML1-ETO by regulating chromatin accessibility. PMID:34938963
Prognostic biomarker SMARCC1 and its association with immune infiltrates in hepatocellular carcinoma. PMID:34937564
High miR-3609 expression is associated with better prognosis in TNBC based on mining using systematic integrated public sequencing data. PMID:34934431
Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer. PMID:34933180
FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer. PMID:34932854
The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells. PMID:34930366
Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer. PMID:34930255
cbpManager: a web application to streamline the integration of clinical and genomic data in cBioPortal to support the Molecular Tumor Board. PMID:34930224
Comprehensive Analysis of Aldehyde Dehydrogenases (ALDHs) and Its Significant Role in Hepatocellular Carcinoma. PMID:34928471
KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis. PMID:34925656
Identification and Validation of a Novel Pyroptosis-Related Gene Signature for Prognosis Prediction in Soft Tissue Sarcoma. PMID:34925457
Prognostic Implications and Immune Infiltration Analysis of ALDOA in Lung Adenocarcinoma. PMID:34925439
The Systematic Landscape of Nectin Family and Nectin-Like Molecules: Functions and Prognostic Value in Low Grade Glioma. PMID:34925438
A Pan-Cancer Analysis of the Oncogenic Role of Integrin Beta4 (ITGB4) in Human Tumors. PMID:34924769
Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation. PMID:34922480
Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis. PMID:34921158
KRAS mutation-independent downregulation of MAPK/PI3K signaling in colorectal cancer. PMID:34919787
Cancer-derived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart. PMID:34918105
Changes in gene-gene interactions associated with cancer onset and progression are largely independent of changes in gene expression. PMID:34917899
Identifying a Hypoxia-Related Long Non-Coding RNAs Signature to Improve the Prediction of Prognosis and Immunotherapy Response in Hepatocellular Carcinoma. PMID:34917132
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. PMID:34910928
Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach. PMID:34910921
Epidermal Integrin α3β1 Regulates Tumor-Derived Proteases BMP-1, Matrix Metalloprotease-9, and Matrix Metalloprotease-3. PMID:34909716
Integrative analysis reveals methylenetetrahydrofolate dehydrogenase 1-like as an independent shared diagnostic and prognostic biomarker in five different human cancers. PMID:34908119
Heterogeneity of non-alcoholic fatty liver disease: Implications for clinical practice and research activity. PMID:34904031
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response. PMID:34903738
LRMP Associates With Immune Infiltrates and Acts as a Prognostic Biomarker in Lung Adenocarcinoma. PMID:34901148
Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics. PMID:34900668
A Network-Centric Framework for the Evaluation of Mutual Exclusivity Tests on Cancer Drivers. PMID:34899838
KRAS signaling in malignant pleural mesothelioma. PMID:34898002
BoxCar and shotgun proteomic analyses reveal molecular networks regulated by UBR5 in prostate cancer. PMID:34897998
High Expression of VAV Gene Family Predicts Poor Prognosis of Acute Myeloid Leukemia. PMID:34894858
MLL4 mediates differentiation and tumor suppression through ferroptosis. PMID:34890228
The Use of Machine Learning to Create a Risk Score to Predict Survival in Patients with Hepatocellular Carcinoma: A TCGA Cohort Analysis. PMID:34888264
A Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF1. PMID:34888238
S100A2 Is a Prognostic Biomarker Involved in Immune Infiltration and Predict Immunotherapy Response in Pancreatic Cancer. PMID:34887861
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1. PMID:34887559
NF-Y subunits overexpression in gastric adenocarcinomas (STAD). PMID:34887475
Sensitizing tumors to anti-PD-1 therapy by promoting NK and CD8+ T cells via pharmacological activation of FOXO3. PMID:34887262
Mismatch Repair Deficiency and Somatic Mutations in Human Sinonasal Tumors. PMID:34885191
An Observational Study on the Molecular Profiling of Primary Melanomas Reveals a Progression Dependence on Mitochondrial Activation. PMID:34885173
Histopathological and Molecular Profiling of Clear Cell Sarcoma and Correlation with Response to Crizotinib: An Exploratory Study Related to EORTC 90101 "CREATE" Trial. PMID:34885165
Pathogen-Induced Epigenetic Modifications in Cancers: Implications for Prevention, Detection and Treatment of Cancers in Africa. PMID:34885162
Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma. PMID:34885146
Stromal Cells Promote Matrix Deposition, Remodelling and an Immunosuppressive Tumour Microenvironment in a 3D Model of Colon Cancer. PMID:34885111
Gene Expression in Barrett's Esophagus Cell Lines Resemble Esophageal Squamous Cell Carcinoma Instead of Esophageal Adenocarcinoma. PMID:34885081
RAP1/TERF2IP-A Multifunctional Player in Cancer Development. PMID:34885080
DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review. PMID:34884835
Targeting Oncogenic Transcriptional Networks in Neuroblastoma: From N-Myc to Epigenetic Drugs. PMID:34884690
Molecular Determinants and Specificity of mRNA with Alternatively-Spliced UPF1 Isoforms, Influenced by an Insertion in the 'Regulatory Loop'. PMID:34884553
Hypomethylation-driven AKT Serine/Threonine Kinase 3 promotes testicular germ cell tumors proliferation and negatively correlates to immune infiltration. PMID:34882061
PRRC2A Promotes Hepatocellular Carcinoma Progression and Associates with Immune Infiltration. PMID:34881207
Computational analysis of cancer genome sequencing data. PMID:34880424
SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects. PMID:34879275
Landscape of the oncogenic role of fatty acid synthase in human tumors. PMID:34879004
Comprehensive Analysis of LPCATs Highlights the Prognostic and Immunological Values of LPCAT1/4 in Hepatocellular Carcinoma. PMID:34876845
Characterization of the GATA Transcription Factor Family and Exploration of Their Relevance to Immune Infiltration and Tumor Microenvironment in Pancreatic Cancer. PMID:34876843
A computational approach for the discovery of significant cancer genes by weighted mutation and asymmetric spreading strength in networks. PMID:34876593
Branching clonal evolution patterns predominate mutational landscape in multiple myeloma. PMID:34873486
A radiogenomics application for prognostic profiling of endometrial cancer. PMID:34873276
Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells. PMID:34871413
Development of a 15-Gene Signature Model as a Prognostic Tool in Sex Hormone-Dependent Cancers. PMID:34869761
Deciphering CHFR Role in Pancreatic Ductal Adenocarcinoma. PMID:34869418
Comprehensive Analysis and Identification of Prognostic Biomarkers and Therapeutic Targets Among FAM83 Family Members for Gastric Cancer. PMID:34869310
OLFML2B Is a Robust Prognostic Biomarker in Bladder Cancer Through Genome-Wide Screening: A Study Based on Seven Cohorts. PMID:34868901
Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma. PMID:34863298
From biobank and data silos into a data commons: convergence to support translational medicine. PMID:34863191
The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis. PMID:34863151
Association of PTPRT mutations with immune checkpoint inhibitors response and outcome in melanoma and non-small cell lung cancer. PMID:34862763
Targeting cancer metabolism in the era of precision oncology. PMID:34862480
Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML. PMID:34862459
Chromosome Missegregation as a Modulator of Radiation Sensitivity. PMID:34861996
Impact of TP53 Genomic Alterations in Large B-Cell Lymphoma Treated With CD19-Chimeric Antigen Receptor T-Cell Therapy. PMID:34860572
Multiomics profiling of the expression and prognosis of MCMs in endometrial carcinoma. PMID:34859821
An Integrative Pan-Cancer Analysis of PBK in Human Tumors. PMID:34859049
Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis. PMID:34858987
Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC. PMID:34858826
Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis. PMID:34858730
PPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer. PMID:34858479
Clinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine. PMID:34858045
miR-17 acts as a tumor suppressor by negatively regulating the miR-17-92 cluster. PMID:34853714
Emergence of mTOR mutation as an acquired resistance mechanism to AKT inhibition, and subsequent response to mTORC1/2 inhibition. PMID:34853384
The prognostic value of TPM1-4 in hepatocellular carcinoma. PMID:34850589
Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers. PMID:34849607
Real-World Approach for Molecular Analysis of Acquired EGFR Tyrosine Kinase Inhibitor Resistance Mechanisms in NSCLC. PMID:34849493
Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model. PMID:34849464
SKA3 Serves as a Biomarker for Poor Prognosis in Kidney Renal Papillary Cell Carcinoma. PMID:34849004
In vivo optical imaging-guided targeted sampling for precise diagnosis and molecular pathology. PMID:34848749
Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma. PMID:34848557
Molecular, clinical, and prognostic implications of PTPN11 mutations in acute myeloid leukemia. PMID:34847232
Genetic and epigenetic regulation of the NRF2-KEAP1 pathway in human lung cancer. PMID:34845361
Selective KRAS G12C inhibitors in non-small cell lung cancer: chemistry, concurrent pathway alterations, and clinical outcomes. PMID:34845311
The NUCKS1-SKP2-p21/p27 axis controls S phase entry. PMID:34845229
Prognostic and Immunological Significance of CXCR2 in Ovarian Cancer: A Promising Target for Survival Outcome and Immunotherapeutic Response Assessment. PMID:34840630
Prognostic Value Estimation of BRIP1 in Breast Cancer by Exploiting Transcriptomics Data Through Bioinformatics Approaches. PMID:34840500
MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance. PMID:34839359
Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients. PMID:34839279
AZD4547 targets the FGFR/Akt/SOX2 axis to overcome paclitaxel resistance in head and neck cancer. PMID:34837170
Bioinformatics Analysis Identifies Precision Treatment with Paclitaxel for Hepatocellular Carcinoma Patients Harboring Mutant TP53 or Wild-Type CTNNB1 Gene. PMID:34834551
Reciprocal Regulation of Hippo and WBP2 Signalling-Implications in Cancer Therapy. PMID:34831354
Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer. PMID:34830941
Melanoma Immunotherapy and Precision Medicine in the Era of Tumor Micro-Tissue Engineering: Where Are We Now and Where Are We Going? PMID:34830940
Cyclin E1 in Murine and Human Liver Cancer: A Promising Target for Therapeutic Intervention during Tumour Progression. PMID:34830835
Integrated Multi-Omics Investigations of Metalloproteinases in Colon Cancer: Focus on MMP2 and MMP9. PMID:34830271
p130Cas Is Correlated with EREG Expression and a Prognostic Factor Depending on Colorectal Cancer Stage and Localization Reducing FOLFIRI Efficacy. PMID:34830244
Patient-Specific Modeling of Diffuse Large B-Cell Lymphoma. PMID:34829885
Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma. PMID:34829830
Identification of NSP3 (SH2D3C) as a Prognostic Biomarker of Tumor Progression and Immune Evasion for Lung Cancer and Evaluation of Organosulfur Compounds from Allium sativum L. as Therapeutic Candidates. PMID:34829812
RANK-C Expression Sensitizes ER-Negative, EGFR-Positive Breast Cancer Cells to EGFR-Tyrosine Kinase Inhibitors (TKIs). PMID:34828291
The Identification of RNA Modification Gene PUS7 as a Potential Biomarker of Ovarian Cancer. PMID:34827123
Identification of LIG1 and LIG3 as prognostic biomarkers in breast cancer. PMID:34825062
A ubiquitous disordered protein interaction module orchestrates transcription elongation. PMID:34822292
Efficacy of Targeted Inhibitors in Metastatic Lung Squamous Cell Carcinoma With EGFR or ALK Alterations. PMID:34820641
Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells. PMID:34820606
KRAS A146 Mutations Are Associated With Distinct Clinical Behavior in Patients With Colorectal Liver Metastases. PMID:34820593
Q-omics: Smart Software for Assisting Oncology and Cancer Research. PMID:34819397
Predicting master transcription factors from pan-cancer expression data. PMID:34818047
Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy. PMID:34815254
TMPRSS4 promotes cancer stem-like properties in prostate cancer cells through upregulation of SOX2 by SLUG and TWIST1. PMID:34809669
Mitotic Errors Promote Genomic Instability and Leukemia in a Novel Mouse Model of Fanconi Anemia. PMID:34804941
Comprehensive Analysis of m6A RNA Methylation Regulators in the Prognosis and Immune Microenvironment of Multiple Myeloma. PMID:34804925
Overexpressing IFITM family genes predict poor prognosis in kidney renal clear cell carcinoma. PMID:34804826
Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer. PMID:34804118
Comprehensive Analysis of m6A RNA Methylation Regulators and the Immune Microenvironment to Aid Immunotherapy in Pancreatic Cancer. PMID:34804059
Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma. PMID:34799547
Hsa-miR-21-3p associates with breast cancer patient survival and targets genes in tumor suppressive pathways. PMID:34797887
PANX1 is a potential prognostic biomarker associated with immune infiltration in pancreatic adenocarcinoma: A pan-cancer analysis. PMID:34796785
Role of FRG1 in predicting the overall survivability in cancers using multivariate based optimal model. PMID:34795329
ZNF76 predicts prognosis and response to platinum chemotherapy in human ovarian cancer. PMID:34793589
A computational in silico approach to predict high-risk coding and non-coding SNPs of human PLCG1 gene. PMID:34793541
SLC7A5 is linked to increased expression of genes related to proliferation and hypoxia in estrogen‑receptor‑positive breast cancer. PMID:34792178
The F-box protein, FBXO7, is required to maintain chromosome stability in humans. PMID:34791250
Low Expression of SLC7A11 Confers Drug Resistance and Worse Survival in Ovarian Cancer via Inhibition of Cell Autophagy as a Competing Endogenous RNA. PMID:34790572
Prognostic and immune infiltrates for the Chromobox (CBX) protein family in human pancreatic adenocarcinoma. PMID:34790394
Prediction and prognostic significance of ALOX12B and PACSIN1 expression in gastric cancer by genome-wide RNA expression and methylation analysis. PMID:34790376
A Cholesterol Homeostasis-Related Gene Signature Predicts Prognosis of Endometrial Cancer and Correlates With Immune Infiltration. PMID:34790227
RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination. PMID:34789768
Clinical and genomic features of SPOP-mutant prostate cancer. PMID:34783071
Discovery proteomics defines androgen-regulated glycoprotein networks in prostate cancer cells, as well as putative biomarkers of prostatic diseases. PMID:34782677
Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers. PMID:34782604
Genomic Alterations in Human Papillomavirus-Positive and -Negative Conjunctival Squamous Cell Carcinomas. PMID:34779821
Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma. PMID:34779417
Radioresistance of Human Cancers: Clinical Implications of Genetic Expression Signatures. PMID:34778082
Molecular Characterization of the Highest Risk Adult Patients With Acute Myeloid Leukemia (AML) Through Multi-Omics Clustering. PMID:34777485
Roles of HMGBs in Prognosis and Immunotherapy: A Pan-Cancer Analysis. PMID:34777483
CSNK2 in cancer: pathophysiology and translational applications. PMID:34773100
Mutant p53 elicits context-dependent pro-tumorigenic phenotypes. PMID:34773073
The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes. PMID:34772942
Papillary Thyroid Cancer Prognosis: An Evolving Field. PMID:34771729
Drug Repositioning Based on the Reversal of Gene Expression Signatures Identifies TOP2A as a Therapeutic Target for Rectal Cancer. PMID:34771654
Genomic Instability of Circulating Tumor DNA as a Prognostic Marker for Pancreatic Cancer Survival: A Prospective Cohort Study. PMID:34771630
Clinical Value of NGS Genomic Studies for Clinical Management of Pediatric and Young Adult Bone Sarcomas. PMID:34771600
Individualized Proteogenomics Reveals the Mutational Landscape of Melanoma Patients in Response to Immunotherapy. PMID:34771574
Elevated Level of Nerve Growth Factor (NGF) in Serum-Derived Exosomes Predicts Poor Survival in Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy. PMID:34771423
Relevance of BRAF Subcellular Localization and Its Interaction with KRAS and KIT Mutations in Skin Melanoma. PMID:34769348
The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors. PMID:34769213
Deciphering the Genomic Landscape and Pharmacological Profile of Uncommon Entities of Adult Rhabdomyosarcomas. PMID:34768995
Systematic Analysis of FASTK Gene Family Alterations in Cancer. PMID:34768773
Alternative polyadenylation: An untapped source for prostate cancer biomarkers and therapeutic targets? PMID:34765448
Different members of the APOBEC3 family of DNA mutators have opposing associations with the landscape of breast cancer. PMID:34765315
Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells. PMID:34764293
TAp63 regulates bone remodeling by modulating the expression of TNFRSF11B/Osteoprotegerin. PMID:34763601
Role of caveolin-1 as a biomarker for radiation resistance and tumor aggression in lung cancer. PMID:34762666
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype. PMID:34762647
The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi-omics study. PMID:34761566
A comprehensive analysis of prefoldins and their implication in cancer. PMID:34761191
The Clinical Significance and Immunization of MSMO1 in Cervical Squamous Cell Carcinoma Based on Bioinformatics Analysis. PMID:34759952
Characterization and prognostic value of LXR splice variants in triple-negative breast cancer. PMID:34755086
Functional drug-target-disease network analysis of gene-phenotype connectivity for curcumin in hepatocellular carcinoma. PMID:34754622
Narrative online guides for the interpretation of digital-pathology images and tissue-atlas data. PMID:34750536
YTH domain family: potential prognostic targets and immune-associated biomarkers in hepatocellular carcinoma. PMID:34747720
Genome Instability and Long Noncoding RNA Reveal Biomarkers for Immunotherapy and Prognosis and Novel Competing Endogenous RNA Mechanism in Colon Adenocarcinoma. PMID:34746134
Re-Identification of Patient Subgroups in Uveal Melanoma. PMID:34745953
Knockdown of LMTK3 in the Endometrioid Adenocarcinoma Cell Line Ishikawa: Inhibition of Growth and Estrogen Receptor α. PMID:34745935
Immunogenomic Landscape Analysis of Prognostic Immune-Related Genes in Hepatocellular Carcinoma. PMID:34745496
Ral GEF with the PH Domain and SH3 Binding Motif 1 Regulated by Splicing Factor Junction Plakoglobin and Pyrimidine Metabolism Are Prognostic in Uterine Carcinosarcoma. PMID:34745385
Recognition of DNA Methylation Molecular Features for Diagnosis and Prognosis in Gastric Cancer. PMID:34745226
ZWINT is a Promising Therapeutic Biomarker Associated with the Immune Microenvironment of Hepatocellular Carcinoma. PMID:34744456
Androgen deprivation‑induced OPHN1 amplification promotes castration‑resistant prostate cancer. PMID:34738630
CDCA7 Facilitates Tumor Progression by Directly Regulating CCNA2 Expression in Esophageal Squamous Cell Carcinoma. PMID:34737951
Tumor-Infiltrating Immune-Related Long Non-Coding RNAs Indicate Prognoses and Response to PD-1 Blockade in Head and Neck Squamous Cell Carcinoma. PMID:34737735
Significance of TEAD Family in Diagnosis, Prognosis and Immune Response for Ovarian Serous Carcinoma. PMID:34737608
Secreted indicators of androgen receptor activity in breast cancer pre-clinical models. PMID:34736512
A prognostic fibroblast-related risk signature in colorectal cancer. PMID:34735373
Effect of mesenchymal-epithelial transition amplification on immune microenvironment and efficacy of immune checkpoint inhibitors in patients with non-small cell lung cancer. PMID:34734027
Prognostic and tumor-immune infiltration cell signatures in tamoxifen-resistant breast cancers. PMID:34733726
Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3. PMID:34733461
Allele-specific genomic data elucidate the role of somatic gain and copy-number neutral loss of heterozygosity in cancer. PMID:34731645
Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. PMID:34731610
The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma. PMID:34731180
ParsVNN: parsimony visible neural networks for uncovering cancer-specific and drug-sensitive genes and pathways. PMID:34729476
CKS2 Overexpression Correlates with Prognosis and Immune Cell Infiltration in Lung Adenocarcinoma: A Comprehensive Study based on Bioinformatics and Experiments. PMID:34729099
Prognostic evaluation and immune infiltration analysis of five bioinformatic selected genes in hepatocellular carcinoma. PMID:34726341
A mixture model for signature discovery from sparse mutation data. PMID:34724984
Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing. PMID:34724198
SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values. PMID:34722629
Conditional ERK3 overexpression cooperates with PTEN deletion to promote lung adenocarcinoma formation in mice. PMID:34719109
ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition. PMID:34718742
RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs. PMID:34718714
EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers. PMID:34718348
T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma. PMID:34717036
The role of PI3'-lipid signalling in melanoma initiation, progression and maintenance. PMID:34717019
Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse. PMID:34716314
PRCC reduces the sensitivity of cancer cells to DNA damage by inhibiting JNK and ATM/ATR pathways and results in a poor prognosis in hepatocellular carcinoma. PMID:34715922
MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer. PMID:34712921
TNFSF13 Is a Novel Onco-Inflammatory Marker and Correlates With Immune Infiltration in Gliomas. PMID:34712225
Oncogene-mediated metabolic gene signature predicts breast cancer outcome. PMID:34711841
Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation. PMID:34711823
Analysing a Novel RNA-Binding-Protein-Related Prognostic Signature Highly Expressed in Breast Cancer. PMID:34707800
CD47 (Cluster of Differentiation 47). PMID:34707698
Multi-Omics Analysis Identified TMED2 as a Shared Potential Biomarker in Six Subtypes of Human Cancer. PMID:34707394
MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling. PMID:34706761
Combined analysis of PTEN, HER2, and hormone receptors status: remodeling breast cancer risk profiling. PMID:34706703
CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation. PMID:34706306
Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-β-catenin-driven M2 macrophage. PMID:34703882
Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers. PMID:34702252
PIM1 phosphorylation of the androgen receptor and 14-3-3 ζ regulates gene transcription in prostate cancer. PMID:34697370
Mechanism of activation and the rewired network: New drug design concepts. PMID:34693559
Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway. PMID:34693224
Integrated bioinformatics analyses of key genes involved in hepatocellular carcinoma immunosuppression. PMID:34691257
Identification of C3 and FN1 as potential biomarkers associated with progression and prognosis for clear cell renal cell carcinoma. PMID:34688260
Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma. PMID:34687603
Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction. PMID:34686865
NUAK Kinases: Brain-Ovary Axis. PMID:34685740
Prognostic Significance of Dysregulated Epigenomic and Chromatin Modifiers in Cervical Cancer. PMID:34685645
Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers. PMID:34685612
Distinct Clinical Impact and Biological Function of Angiopoietin and Angiopoietin-like Proteins in Human Breast Cancer. PMID:34685578
A Mathematical Model of Breast Tumor Progression Based on Immune Infiltration. PMID:34683171
Deregulation of N6-Methyladenosine RNA Modification and Its Erasers FTO/ALKBH5 among the Main Renal Cell Tumor Subtypes. PMID:34683137
Integrated Molecular Characterization to Reveal the Association between Kynurenine 3-Monooxygenase Expression and Tumorigenesis in Human Breast Cancers. PMID:34683090
Prognostic Value of Interleukin-32 Expression and Its Correlation with the Infiltration of Natural Killer Cells in Cutaneous Melanoma. PMID:34682815
The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells. PMID:34681917
Identification of Tumor Antigens in Ovarian Cancers Using Local and Circulating Tumor-Specific Antibodies. PMID:34681879
Molecular Targets and Promising Therapeutics of Triple-Negative Breast Cancer. PMID:34681231
The Intrinsically Disordered Region in the Human STN1 OB-Fold Domain Is Important for Protecting Genome Stability. PMID:34681076
Clinically Translatable Approaches of Inhibiting TGF-β to Target Cancer Stem Cells in TNBC. PMID:34680503
Expression Profile and Prognostic Value of Wnt Signaling Pathway Molecules in Colorectal Cancer. PMID:34680448
Landscape of Immune-Related Markers and Potential Therapeutic Targets in Soft Tissue Sarcoma. PMID:34680396
Precision Oncology of High-Grade Ovarian Cancer Defined through Targeted Sequencing. PMID:34680387
Altered Expression of Shorter p53 Family Isoforms Can Impact Melanoma Aggressiveness. PMID:34680379
Comprehensive Analysis of VEGFR2 Expression in HPV-Positive and -Negative OPSCC Reveals Differing VEGFR2 Expression Patterns. PMID:34680369
Molecular Signature Expands the Landscape of Driver Negative Thyroid Cancers. PMID:34680332
Prognostic Gene Signature for Squamous Cell Carcinoma with a Higher Risk for Treatment Failure and Accelerated MEK-ERK Pathway Activity. PMID:34680330
Brain and Breast Cancer Cells with PTEN Loss of Function Reveal Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Utilizing 3D Scaffolds and Aligned Microfiber Tracts. PMID:34680293
A Systems Approach to Interrogate Gene Expression Patterns in African American Men Presenting with Clinically Localized Prostate Cancer. PMID:34680291
EGFR Exon 20 Insertion in Metastatic Non-Small-Cell Lung Cancer: Survival and Clinical Efficacy of EGFR Tyrosine-Kinase Inhibitor and Chemotherapy. PMID:34680280
Frequent Epigenetic Inactivation of DIRAS-1 and DIRAS-2 Contributes to Chemo-Resistance in Gliomas. PMID:34680261
Luminescence complementation technology for the identification of MYC:TRRAP inhibitors. PMID:34676047
ATR inhibition reverses the resistance of homologous recombination deficient MGMTlow/MMRproficient cancer cells to temozolomide. PMID:34676045
The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor. PMID:34674701
Proteogenomics Reveals Perturbed Signaling Networks in Malignant Melanoma Cells Resistant to BRAF Inhibition. PMID:34673281
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. PMID:34671754
Pan-Cancer Analysis of the Associations of TGFBI Expression With Prognosis and Immune Characteristics. PMID:34671645
Targeting Long Non-Coding RNA TTN-AS1 Suppresses Bladder Cancer Progression. PMID:34671381
Comprehensive landscape of the renin-angiotensin system in Pan-cancer: a potential downstream mediated mechanism of SARS-CoV-2. PMID:34671200
Ecdysoneless Protein Regulates Viral and Cellular mRNA Splicing to Promote Cervical Oncogenesis. PMID:34670863
Prognostic implications of epidermal and platelet-derived growth factor receptor alterations in 2 cohorts of IDHwt glioblastoma. PMID:34667950
Distinction of lymphoid and myeloid clonal hematopoiesis. PMID:34663986
The Effect of Smoking on the Immune Microenvironment and Immunogenicity and Its Relationship With the Prognosis of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer. PMID:34660603
Prognostic Value and Immunological Role of MORF4-Related Gene-Binding Protein in Human Cancers. PMID:34660575
Identification of Therapeutic Targets and Prognostic Biomarkers Among Integrin Subunits in the Skin Cutaneous Melanoma Microenvironment. PMID:34660316
MELK expression in breast cancer is associated with infiltration of immune cell and pathological compete response (pCR) after neoadjuvant chemotherapy. PMID:34659896
A prognostic score based on long-term survivor unique transcriptomic signatures predicts patient survival in pancreatic ductal adenocarcinoma. PMID:34659888
Serine/threonine-protein kinase 24 is an inhibitor of gastric cancer metastasis through suppressing CDH1 gene and enhancing stemness. PMID:34659887
Genomic profiling of DVL-1 and its nuclear role as a transcriptional regulator in triple negative breast cancer. PMID:34659647
Overexpression of P4HA1 associates with poor prognosis and promotes cell proliferation and metastasis of lung adenocarcinoma. PMID:34659558
Identification of Novel Biomarkers Related to Lung Squamous Cell Carcinoma Using Integrated Bioinformatics Analysis. PMID:34659450
Structure-function relationships explain CTCF zinc finger mutation phenotypes in cancer. PMID:34657170
M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way. PMID:34656164
Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation. PMID:34656143
EZH2 inhibition confers PIK3CA-driven lung tumors enhanced sensitivity to PI3K inhibition. PMID:34655667
C/EBPβ induces B-cell acute lymphoblastic leukemia and cooperates with BLNK mutations. PMID:34653294
Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma. PMID:34651586
The Expression Patterns and Prognostic Value of the Proteasome Activator Subunit Gene Family in Gastric Cancer Based on Integrated Analysis. PMID:34650966
Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers. PMID:34649609
Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma. PMID:34649520
The human GID complex engages two independent modules for substrate recruitment. PMID:34647674
Cancer gene mutation frequencies for the U.S. population. PMID:34645806
Stat1 confers sensitivity to radiation in cervical cancer cells by controlling Parp1 levels: a new perspective for Parp1 inhibition. PMID:34642300
Identification of prostate cancer specific methylation biomarkers from a multi-cancer analysis. PMID:34641790
MET Amplification in Non-Small Cell Lung Cancer (NSCLC)-A Consecutive Evaluation Using Next-Generation Sequencing (NGS) in a Real-World Setting. PMID:34638507
TBX2 Drives Neuroendocrine Prostate Cancer through Exosome-Mediated Repression of miR-200c-3p. PMID:34638504
Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity. PMID:34638503
Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate Cancer. PMID:34638338
Targeted Sequencing Revealed Distinct Mutational Profiles of Ocular and Extraocular Sebaceous Carcinomas. PMID:34638295
The Role of the Hedgehog Pathway in Cholangiocarcinoma. PMID:34638259
Overcoming Immunotherapy Resistance by Targeting the Tumor-Intrinsic NLRP3-HSP70 Signaling Axis. PMID:34638239
The Landscape of Transmembrane Protein Family Members in Head and Neck Cancers: Their Biological Role and Diagnostic Utility. PMID:34638224
Phosphorylation of CAP1 regulates lung cancer proliferation, migration, and invasion. PMID:34636991
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma. PMID:34636321
Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly. PMID:34635648
Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters. PMID:34631566
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis. PMID:34630336
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4. PMID:34628485
rPAC: Route based pathway analysis for cohorts of gene expression data sets. PMID:34628030
Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells. PMID:34626204
6q deletion is frequent but unrelated to patient prognosis in breast cancer. PMID:34625909
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms. PMID:34624218
Predicting endometrial cancer subtypes and molecular features from histopathology images using multi-resolution deep learning models. PMID:34622237
LncRNA RNA Component of Mitochondrial RNA-Processing Endoribonuclease Promotes AKT-Dependent Breast Cancer Growth and Migration by Trapping MicroRNA-206. PMID:34621748
mRNA Network: Solution for Tracking Chemotherapy Insensitivity in Small-Cell Lung Cancer. PMID:34621500
The role of ERBB4 mutations in the prognosis of advanced non-small cell lung cancer treated with immune checkpoint inhibitors. PMID:34620079
Molecular implications of HOX genes targeting multiple signaling pathways in cancer. PMID:34617205
CTHRC1 expression is a novel shared diagnostic and prognostic biomarker of survival in six different human cancer subtypes. PMID:34615943
Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squamous NSCLC. PMID:34615542
Targeted Therapy for BRAF Mutant Brain Tumors. PMID:34613491
Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers. PMID:34611484
Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway. PMID:34611298
Genomic characterization of rare molecular subclasses of hepatocellular carcinoma. PMID:34608257
Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors. PMID:34607897
Centrosome Aberrations as Drivers of Chromosomal Instability in Breast Cancer. PMID:34606589
SNX20AR/MiRNA-301a-3p/SNX20 Axis Associated With Cell Proliferation and Immune Infiltration in Lung Adenocarcinoma. PMID:34604311
Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review. PMID:34604242
Estrogen Receptor Is Expressed in Uveal Melanoma: A Potential Target for Therapy. PMID:34604204
Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis. PMID:34603386
Recognition of Tumor-Associated Antigens and Immune Subtypes in Glioma for mRNA Vaccine Development. PMID:34603319
Genetic evolution to tyrosine kinase inhibitory therapy in patients with EGFR-mutated non-small-cell lung cancer. PMID:34599295
Recurrence-associated gene signature in patients with stage I non-small-cell lung cancer. PMID:34599262
Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer. PMID:34596356
Identification of hub genes and candidate drugs in hepatocellular carcinoma by integrated bioinformatics analysis. PMID:34596112
AGTRAP Is a Prognostic Biomarker Correlated With Immune Infiltration in Hepatocellular Carcinoma. PMID:34595113
Genomic evidence suggests that cutaneous neuroendocrine carcinomas can arise from squamous dysplastic precursors. PMID:34593967
BAP1 methylation: a prognostic marker of uveal melanoma metastasis. PMID:34593944
Response to Immune Checkpoint Inhibition as Monotherapy or in Combination With Chemotherapy in Metastatic ROS1-Rearranged Lung Cancers. PMID:34590036
Genomic and Transcriptomic Characterization of Relapsed SCLC Through Rapid Research Autopsy. PMID:34590014
Structural determinants of peptide-dependent TAP1-TAP2 transit passage targeted by viral proteins and altered by cancer-associated mutations. PMID:34589184
MMP1 and MMP9 are potential prognostic biomarkers and targets for uveal melanoma. PMID:34587931
Pan-cancer analysis indicates that MYBL2 is associated with the prognosis and immunotherapy of multiple cancers as an oncogene. PMID:34585645
Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis. PMID:34585630
MXD3 as an onco-immunological biomarker encompassing the tumor microenvironment, disease staging, prognoses, and therapeutic responses in multiple cancer types. PMID:34584637
HNRNPC Promotes Proliferation, Metastasis and Predicts Prognosis in Prostate Cancer. PMID:34584453
Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation. PMID:34584219
Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer. PMID:34583980
Rational Combination of CRM1 Inhibitor Selinexor and Olaparib Shows Synergy in Ovarian Cancer Cell Lines and Mouse Models. PMID:34583979
MLL3 is a de novo cause of endocrine therapy resistance. PMID:34581028
Expanding the spectrum of thyroid carcinoma with somatic DICER1 mutation: a survey of 829 thyroid carcinomas using MSK-IMPACT next-generation sequencing platform. PMID:34580763
Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models. PMID:34576133
Analysis of SYK Gene as a Prognostic Biomarker and Suggested Potential Bioactive Phytochemicals as an Alternative Therapeutic Option for Colorectal Cancer: An In-Silico Pharmaco-Informatics Investigation. PMID:34575665
Epigenetic Silencing of HER2 Expression during Epithelial-Mesenchymal Transition Leads to Trastuzumab Resistance in Breast Cancer. PMID:34575017
Genetic Variants and Somatic Alterations Associated with MITF-E318K Germline Mutation in Melanoma Patients. PMID:34573422
Identifying New Potential Biomarkers in Adrenocortical Tumors Based on mRNA Expression Data Using Machine Learning. PMID:34572898
Elevating CDCA3 Levels Enhances Tyrosine Kinase Inhibitor Sensitivity in TKI-Resistant EGFR Mutant Non-Small-Cell Lung Cancer. PMID:34572879
Mutations in Epigenetic Regulation Genes in Gastric Cancer. PMID:34572812
The Role of p53 in Progression of Cutaneous Squamous Cell Carcinoma. PMID:34572732
A Preclinical Investigation of GBM-N019 as a Potential Inhibitor of Glioblastoma via Exosomal mTOR/CDK6/STAT3 Signaling. PMID:34572040
Plectin in Cancer: From Biomarker to Therapeutic Target. PMID:34571895
CEBPD Potentiates the Macrophage Inflammatory Response but CEBPD Knock-Out Macrophages Fail to Identify CEBPD-Dependent Pro-Inflammatory Transcriptional Programs. PMID:34571881
Metastatic Castration-Resistant Prostate Cancer Remains Dependent on Oncogenic Drivers Found in Primary Tumors. PMID:34568716
Aberrant DNA Methylation-Mediated FOXF2 Dysregulation Is a Prognostic Risk Factor for Gastric Cancer. PMID:34568422
Integrative Analysis of Biomarkers Through Machine Learning Identifies Stemness Features in Colorectal Cancer. PMID:34568334
The Role of Akt in Acquired Cetuximab Resistant Head and Neck Squamous Cell Carcinoma: An In Vitro Study on a Novel Combination Strategy. PMID:34568028
Chromobox Homolog 8 (CBX8) in Human Tumor Carcinogenesis and Prognosis: A Pancancer Analysis Using Multiple Databases. PMID:34567093
Smarca4 Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung. PMID:34561242
Identification of Novel Molecular Therapeutic Targets and Their Potential Prognostic Biomarkers Among Kinesin Superfamily of Proteins in Pancreatic Ductal Adenocarcinoma. PMID:34557409
Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner. PMID:34556788
Copy number alteration of the interferon gene cluster in cancer: Individual patient data meta-analysis prospects to personalized immunotherapy. PMID:34555656
RAF1 amplification drives a subset of bladder tumors and confers sensitivity to MAPK-directed therapeutics. PMID:34554931
Insulin and the insulin receptor collaborate to promote human gastric cancer. PMID:34554347
Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer. PMID:34554200
Single-cell profiling defines the prognostic benefit of CD39high tissue resident memory CD8+ T cells in luminal-like breast cancer. PMID:34552178
Predicting chemotherapy response using a variational autoencoder approach. PMID:34551729
Single-cell DNA and RNA sequencing reveals the dynamics of intra-tumor heterogeneity in a colorectal cancer model. PMID:34548081
Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents. PMID:34545188
The immunotherapy candidate TNFSF4 may help the induction of a promising immunological response in breast carcinomas. PMID:34545132
Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy. PMID:34545095
Identification of ARHGEF38, NETO2, GOLM1, and SAPCD2 Associated With Prostate Cancer Progression by Bioinformatic Analysis and Experimental Validation. PMID:34540835
Comprehensive Analysis of a Nine-Gene Signature Related to Tumor Microenvironment in Lung Adenocarcinoma. PMID:34540825
CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling. PMID:34539851
A Pan-Cancer Analysis of the Prognostic Value and Expression of Adenylate Cyclase 7 (ADCY7) in Human Tumors. PMID:34539183
Shugosin 2 is a biomarker for pathological grading and survival prediction in patients with gliomas. PMID:34535705
Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer. PMID:34535676
An IDO1-related immune gene signature predicts overall survival in acute myeloid leukemia. PMID:34535017
A newly established monoclonal antibody against ERCC1 detects major isoforms of ERCC1 in gastric cancer. PMID:34532603
Increased RBM12 expression predicts poor prognosis in hepatocellular carcinoma based on bioinformatics. PMID:34532138
SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia. PMID:34531253
Genome-wide association studies of survival in 1520 cancer patients treated with bevacizumab-containing regimens. PMID:34528705
RNA-binding proteins of COSMIC importance in cancer. PMID:34523614
An Overview of the Genomic Characterization of Hepatocellular Carcinoma. PMID:34522690
bFGF-mediated phosphorylation of δ-catenin increases its protein stability and the ability to induce the nuclear redistribution of β-catenin. PMID:34522455
Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter. PMID:34520744
The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis. PMID:34520390
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids. PMID:34518665
Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression. PMID:34518527
Targeting Tumor-Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer. PMID:34518296
Integrative analysis reveals clinically relevant molecular fingerprints in pancreatic cancer. PMID:34513290
YTHDF2 is a Potential Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma. PMID:34512342
Pro-Oncogenic c-Met/EGFR, Biomarker Signatures of the Tumor Microenvironment are Clinical and Therapy Response Prognosticators in Colorectal Cancer, and Therapeutic Targets of 3-Phenyl-2H-benzo[e][1,3]-Oxazine-2,4(3H)-Dione Derivatives. PMID:34512327
Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer. PMID:34509979
Comprehensive characterization of somatic variants associated with intronic polyadenylation in human cancers. PMID:34508351
Proteogenomic analysis of pancreatic cancer subtypes. PMID:34506537
Signet ring cell cancer of stomach and gastro-esophageal junction: molecular alterations, stage-stratified treatment approaches, and future challenges. PMID:34505199
Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression. PMID:34505065
Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases. PMID:34505004
The Cancer Epitope Database and Analysis Resource: A Blueprint for the Establishment of a New Bioinformatics Resource for Use by the Cancer Immunology Community. PMID:34504503
Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity. PMID:34504076
Prognostic and Therapeutic Potential of the OIP5 Network in Papillary Renal Cell Carcinoma. PMID:34503297
Targeting CD82/KAI1 for Precision Therapeutics in Surmounting Metastatic Potential in Breast Cancer. PMID:34503296
Playing on the Dark Side: SMYD3 Acts as a Cancer Genome Keeper in Gastrointestinal Malignancies. PMID:34503239
TP53 in Biology and Treatment of Osteosarcoma. PMID:34503094
A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML. PMID:34502319
Unraveling the Relevance of ARL GTPases in Cutaneous Melanoma Prognosis through Integrated Bioinformatics Analysis. PMID:34502169
Zinc Favors Triple-Negative Breast Cancer's Microenvironment Modulation and Cell Plasticity. PMID:34502091
RNA binding motif 47 (RBM47): emerging roles in vertebrate development, RNA editing and cancer. PMID:34499322
Stress-activated kinases as therapeutic targets in pancreatic cancer. PMID:34497429
Dysregulated paired related homeobox 1 impacts on hepatocellular carcinoma phenotypes. PMID:34496784
Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity. PMID:34496233
Transcriptional analysis of the expression, prognostic value and immune infiltration activities of the COMMD protein family in hepatocellular carcinoma. PMID:34493238
Pan-Cancer Analysis Identified C1ORF112 as a Potential Biomarker for Multiple Tumor Types. PMID:34490347
Integrative Analysis of Minichromosome Maintenance Proteins and Their Prognostic Significance in Melanoma. PMID:34490114
Prognostic role of EGR1 in breast cancer: a systematic review. PMID:34488929
The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy. PMID:34488905
Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8. PMID:34488871
Carcinogenic effect of adenylosuccinate lyase (ADSL) in prostate cancer development and progression through the cell cycle pathway. PMID:34488772
Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis. PMID:34488675
Integrated analysis of Solute carrier family-2 members reveals SLC2A4 as an independent favorable prognostic biomarker for breast cancer. PMID:34488531
A pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers. PMID:34486492
Gene expression and prognosis of x-ray repair cross-complementing family members in non-small cell lung cancer. PMID:34486486
Zooming in on the WNT/CTNNB1 Destruction Complex: Functional Mechanistic Details with Implications for Therapeutic Targeting. PMID:34486095
Transcriptomic Analyses Reveal B-Cell Translocation Gene 2 as a Potential Therapeutic Target in Ovarian Cancer. PMID:34485119
Kinase fusion-related thyroid carcinomas: distinct pathologic entities with evolving diagnostic implications. PMID:34484420
Nicardipine Inhibits Breast Cancer Migration via Nrf2/HO-1 Axis and Matrix Metalloproteinase-9 Regulation. PMID:34483918
Cancer testis antigens and genomic instability: More than immunology. PMID:34481156
SAMHD1 in cancer: curse or cure? PMID:34480199
Telomeric zinc-finger associated protein (TZAP) in cancer biology: friend or foe? PMID:34476265
Overexpression of TMEFF1 in Endometrial Carcinoma and the Mechanism Underlying its Promotion of Malignant Behavior in Cancer Cells. PMID:34475991
The Alterations and Potential Roles of MCMs in Breast Cancer. PMID:34475953
Novel diagnostic and prognostic biomarkers of colorectal cancer: Capable to overcome the heterogeneity-specific barrier and valid for global applications. PMID:34473751
The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway. PMID:34471290
Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes. PMID:34470661
Virus-host interactions in carcinogenesis of Epstein-Barr virus-associated gastric carcinoma: Potential roles of lost ARID1A expression in its early stage. PMID:34469459
Integrative overview of IFITMs family based on Bioinformatics analysis. PMID:34466338
Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes. PMID:34465782
Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study. PMID:34464379
Systematic Analysis of Cytostatic TGF-Beta Response in Mesenchymal-Like Hepatocellular Carcinoma Cell Lines. PMID:34463913
Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients. PMID:34461927
Mnt Represses Epithelial Identity To Promote Epithelial-to-Mesenchymal Transition. PMID:34460331
Interferon-Induced Transmembrane Protein 3 Shapes an Inflamed Tumor Microenvironment and Identifies Immuno-Hot Tumors. PMID:34456915
MEX3D is an oncogenic driver in prostate cancer. PMID:34455614
Pan-cancer analysis of the oncogenic role of discs large homolog associated protein 5 (DLGAP5) in human tumors. PMID:34454476
SMAD4 is critical in suppression of BRAF-V600E serrated tumorigenesis. PMID:34453124
Ruthenium Complexes: An Alternative to Platinum Drugs in Colorectal Cancer Treatment. PMID:34452256
Genomic Profiling of Prostate Cancer: An Updated Review. PMID:34448375
Epigenetic Deregulation of the Histone Methyltransferase KMT5B Contributes to Malignant Transformation in Glioblastoma. PMID:34447744
Loss of ARID1A Promotes Hepatocellular Carcinoma Progression via Up-regulation of MYC Transcription. PMID:34447682
Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes. PMID:34446793
Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity. PMID:34446728
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer. PMID:34446716
Syndecan Family Gene and Protein Expression and Their Prognostic Values for Prostate Cancer. PMID:34445387
The SCF Complex Is Essential to Maintain Genome and Chromosome Stability. PMID:34445249
Multi-Omics Analysis of SOX4, SOX11, and SOX12 Expression and the Associated Pathways in Human Cancers. PMID:34442467
Unraveling the Epigenetic Role and Clinical Impact of Histone Deacetylases in Neoplasia. PMID:34441281
Association of TP53 Alteration with Tissue Specificity and Patient Outcome of IDH1-Mutant Glioma. PMID:34440884
Comprehensive Integrative Analysis Reveals the Association of KLF4 with Macrophage Infiltration and Polarization in Lung Cancer Microenvironment. PMID:34440860
Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer. PMID:34440533
Transcriptional Regulation of RUNX1: An Informatics Analysis. PMID:34440349
Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers. PMID:34440228
Non-Coding RNA-Based Biosensors for Early Detection of Liver Cancer. PMID:34440168
Predicting Agents That Can Overcome 5-FU Resistance in Colorectal Cancers via Pharmacogenomic Analysis. PMID:34440086
GNAi2/gip2-Regulated Transcriptome and Its Therapeutic Significance in Ovarian Cancer. PMID:34439877
Chromoanagenesis Landscape in 10,000 TCGA Patients. PMID:34439350
Pan-Cancer Analysis of Immune Complement Signature C3/C5/C3AR1/C5AR1 in Association with Tumor Immune Evasion and Therapy Resistance. PMID:34439277
EVI2B Is a New Prognostic Biomarker in Metastatic Melanoma with IFNgamma Associated Immune Infiltration. PMID:34439264
Hypoxic Jumbo Spheroids On-A-Chip (HOnAChip): Insights into Treatment Efficacy. PMID:34439199
3q26 Amplifications in Cervical Squamous Carcinomas. PMID:34436017
Small cell lung cancer transformation during antitumor therapies: A systematic review. PMID:34435141
Identification of a Costimulatory Molecule Gene Signature to Predict Survival and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma. PMID:34434928
A clinically applicable integrative molecular classification of meningiomas. PMID:34433969
Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma. PMID:34433873
How to Achieve Therapeutic Response in Erlotinib-Resistant Head and Neck Squamous Cell Carcinoma? New Insights from Stable Isotope Labeling with Amino Acids in Cell Culture-Based Quantitative Tyrosine Phosphoproteomics. PMID:34432535
Identification of GNA12-driven gene signatures and key signaling networks in ovarian cancer. PMID:34429759
Elevated mRNA Level of Y-Box Binding Protein 1 Indicates Unfavorable Prognosis Correlated with Macrophage Infiltration and T Cell Exhaustion in Luminal Breast Cancer. PMID:34429650
Mechanisms of targeted therapy resistance in a pediatric glioma driven by ETV6-NTRK3 fusion. PMID:34429303
SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia. PMID:34426610
IL6 and BCL3 Expression Are Potential Biomarkers in Esophageal Squamous Cell Carcinoma. PMID:34422669
DNA repair genes are associated with tumor tissue differentiation and immune environment in lung adenocarcinoma: a bioinformatics analysis based on big data. PMID:34422373
Basic Pan-Cancer Analysis of the Carcinogenic Effects of Cyclin-Dependent Kinase 4 (CDK4) in Human Surface Tumors. PMID:34422248
Predictive Value of the TP53/PIK3CA/ATM Mutation Classifier for Patients With Bladder Cancer Responding to Immune Checkpoint Inhibitor Therapy. PMID:34421886
BC-N102 suppress breast cancer tumorigenesis by interfering with cell cycle regulatory proteins and hormonal signaling, and induction of time-course arrest of cell cycle at G1/G0 phase. PMID:34421361
Effect of LAMA4 on Prognosis and Its Correlation with Immune Infiltration in Gastric Cancer. PMID:34414238
Two Similar Signatures for Predicting the Prognosis and Immunotherapy Efficacy of Stomach Adenocarcinoma Patients. PMID:34414187
DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma. PMID:34414037
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology. PMID:34413304
ATR Inhibitor M6620 (VX-970) Enhances the Effect of Radiation in Non-Small Cell Lung Cancer Brain Metastasis Patient-Derived Xenografts. PMID:34413128
Ten simple rules for creating reusable pathway models for computational analysis and visualization. PMID:34411100
YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer. PMID:34408926
Targeting AXL in NSCLC. PMID:34408519
Recurrent Human Papillomavirus-Related Head and Neck Cancer Undergoes Metabolic Reprogramming and Is Driven by Oxidative Phosphorylation. PMID:34407971
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice. PMID:34406363
Clinical, genetic and pharmacological data support targeting the MEK5/ERK5 module in lung cancer. PMID:34404896
ZNF768 links oncogenic RAS to cellular senescence. PMID:34404770
Bioinformatics analysis of the transcriptional expression of minichromosome maintenance proteins as potential indicators of survival in patients with cervical cancer. PMID:34404366
DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling. PMID:34399732
A novel treatment strategy for lapatinib resistance in a subset of HER2-amplified gastric cancer. PMID:34399705
Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls. PMID:34398495
Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database. PMID:34397798
Prognostic Prediction, Immune Microenvironment, and Drug Resistance Value of Collagen Type I Alpha 1 Chain: From Gastrointestinal Cancers to Pan-Cancer Analysis. PMID:34395525
Potential Role of SWI/SNF Complex Subunit Actin-Like Protein 6A in Cervical Cancer. PMID:34395295
Dissecting the biological heterogeneity of HER2-positive breast cancer. PMID:34392185
MEK inhibition overcomes resistance to EphA2-targeted therapy in uterine cancer. PMID:34391578
Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A. PMID:34390123
Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer. PMID:34389806
Genomic landscape of a mouse model of diffuse-type gastric adenocarcinoma. PMID:34387762
Polyfunctional KLRG-1+CD57+ Senescent CD4+ T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients. PMID:34386013
Prognostic and Immunological Role of Gasdermin E in Pan-Cancer Analysis. PMID:34381728
Comprehensive Analysis of the Expression Characteristics of the Enhancer of the Zeste Homolog 2 Gene in Pan-Cancer. PMID:34381492
Comprehensive Analysis of the Expression and Prognostic Value of SPINT1/2 in Breast Carcinoma. PMID:34381422
A merged microarray meta-dataset for transcriptionally profiling colorectal neoplasm formation and progression. PMID:34381057
A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis. PMID:34381052
Pan-Cancer Survival Classification With Clinicopathological and Targeted Gene Expression Features. PMID:34376966
The evolution of hematopoietic cells under cancer therapy. PMID:34376657
SWI/SNF complex alterations as a biomarker of immunotherapy efficacy in pancreatic cancer. PMID:34375311
Molecular Pathology of Urothelial Carcinoma. PMID:34373092
Evidence for AJUBA-catenin-CDH4-linked differentiation resistance of mesenchymal stem cells implies tumorigenesis and progression of head and neck squamous cell carcinoma: a single-cell transcriptome approach. PMID:34368804
Multi-Omics Integrative Bioinformatics Analyses Reveal Long Non-coding RNA Modulates Genomic Integrity via Competing Endogenous RNA Mechanism and Serves as Novel Biomarkers for Overall Survival in Lung Adenocarcinoma. PMID:34368141
Phosphoinositide Recognition Sites Are Blocked by Metabolite Attachment. PMID:34368138
Acylglycerol Kinase-Targeted Therapies in Oncology. PMID:34368119
PSMB7 Is a Key Gene Involved in the Development of Multiple Myeloma and Resistance to Bortezomib. PMID:34367968
Multi-Omic Analyses of the m5C Regulator ALYREF Reveal Its Essential Roles in Hepatocellular Carcinoma. PMID:34367948
E2F3 drives the epithelial-to-mesenchymal transition, cell invasion, and metastasis in breast cancer. PMID:34365840
Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting. PMID:34364401
Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis. PMID:34364391
hMOB2 deficiency impairs homologous recombination-mediated DNA repair and sensitises cancer cells to PARP inhibitors. PMID:34363951
Polymorphous Low-Grade Neuroepithelial Tumor of the Young (PLNTY): Molecular Profiling Confirms Frequent MAPK Pathway Activation. PMID:34363682
Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction. PMID:34362880
BCL7A as a novel prognostic biomarker for glioma patients. PMID:34362400
NF1-Dependent Transcriptome Regulation in the Melanocyte Lineage and in Melanoma. PMID:34362135
Tumor Promoting Effect of BMP Signaling in Endometrial Cancer. PMID:34360647
The Most Common VHL Point Mutation R167Q in Hereditary VHL Disease Interferes with Cell Plasticity Regulation. PMID:34359798
Glutamatergic Signaling a Therapeutic Vulnerability in Melanoma. PMID:34359771
The Role of DND1 in Cancers. PMID:34359581
Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer. PMID:34356885
Molecular and Pathological Profiling of Corresponding Treatment-Naïve and Neoadjuvant Pazopanib-Treated High-Risk Soft Tissue Sarcoma Samples of the GISG-04/NOPASS Study. PMID:34356494
Context-Dependent Roles of Claudins in Tumorigenesis. PMID:34354941
Increased apoptosis is associated with robust immune cell infiltration and cytolytic activity in breast cancer. PMID:34354867
A novel five-gene score to predict complete pathological response to neoadjuvant chemotherapy in ER-positive/HER2-negative breast cancer. PMID:34354863
Analyzing Roles of NUSAP1 From Clinical, Molecular Mechanism and Immune Perspectives in Hepatocellular Carcinoma. PMID:34354737
Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation. PMID:34352208
Pancreas cancer and BRCA: A critical subset of patients with improving therapeutic outcomes. PMID:34351646
Dual inhibition of FGFR4 and BCL-xL inhibits multi-resistant ovarian cancer with BCL2L1 gain. PMID:34351305
In silico assessment of EpCAM transcriptional expression and determination of the prognostic biomarker for human lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). PMID:34345719
Sensitivity to targeted therapy differs between HER2-amplified breast cancer cells harboring kinase and helical domain mutations in PIK3CA. PMID:34344439
Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study. PMID:34343214
Comprehensive characterization of pathological stage-related genes of papillary thyroid cancer along with survival prediction. PMID:34342109
Revisiting vimentin: a negative surrogate marker of molecularly defined oligodendroglioma in adult type diffuse glioma. PMID:34338912
Linking genome variants to disease: scalable approaches to test the functional impact of human mutations. PMID:34338757
A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. PMID:34337560
An Integrated Deep Network for Cancer Survival Prediction Using Omics Data. PMID:34337396
Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast Cancer. PMID:34336686
A Novel Five-Gene Signature for Prognosis Prediction in Hepatocellular Carcinoma. PMID:34336648
Identification and Validation of a Prognostic Signature for Prostate Cancer Based on Ferroptosis-Related Genes. PMID:34336641
Significant Diagnostic and Prognostic Value of FLAD1 and Related MicroRNAs in Breast Cancer after a Pan-Cancer Analysis. PMID:34336008
Snail1 expression in endothelial cells controls growth, angiogenesis and differentiation of breast tumors. PMID:34335957
Integrative Bioinformatics Study of Tangeretin Potential Targets for Preventing Metastatic Breast Cancer. PMID:34335799
Comprehensive Analysis of the Value of SMYD Family Members in the Prognosis and Immune Infiltration of Malignant Digestive System Tumors. PMID:34335697
SIRT4 and SIRT6 Serve as Novel Prognostic Biomarkers With Competitive Functions in Serous Ovarian Cancer. PMID:34335684
Nucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma. PMID:34334108
Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer. PMID:34329194
Lung adenocarcinoma patients with KEAP1 mutation harboring low immune cell infiltration and low activity of immune environment. PMID:34328274
Glycoprotein non-metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation. PMID:34327762
A Comprehensive Pan-Cancer Analysis of RBM8A Based on Data Mining. PMID:34326876
RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway. PMID:34326698
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer. PMID:34326322
Germ-line mutations in WDR77 predispose to familial papillary thyroid cancer. PMID:34326253
Activation of the ABCB1 Amplicon in Docetaxel- and Cabazitaxel-Resistant Prostate Cancer Cells. PMID:34326198
UCSCXenaShiny: An R/CRAN Package for Interactive Analysis of UCSC Xena Data. PMID:34323947
Pan-Cancer Prognostic Role and Targeting Potential of the Estrogen-Progesterone Axis. PMID:34322374
Bioinformatics Analysis of KIF1A Expression and Gene Regulation Network in Ovarian Carcinoma. PMID:34321916
The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core. PMID:34316696
PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer. PMID:34315821
Construction of a novel mRNA-signature prediction model for prognosis of bladder cancer based on a statistical analysis. PMID:34315402
The role of YTH domain containing 2 in epigenetic modification and immune infiltration of pan-cancer. PMID:34312987
RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer. PMID:34312180
Functional impact of cancer patient-associated Bcl-xL mutations. PMID:34308416
Pan-Cancer Survey of Tumor Mass Dormancy and Underlying Mutational Processes. PMID:34307377
Transcriptomic Analysis Identified ARHGAP Family as a Novel Biomarker Associated With Tumor-Promoting Immune Infiltration and Nanomechanical Characteristics in Bladder Cancer. PMID:34307347
Expression and Clinical Significance of Lactate Dehydrogenase A in Colon Adenocarcinoma. PMID:34307169
Identification of Predictive Biomarkers for Lymph Node Involvement in Obese Women With Endometrial Cancer. PMID:34307159
Genomic alterations and possible druggable mutations in carcinoma of unknown primary (CUP). PMID:34302033
AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B. PMID:34301793
Targeting EGFR Exon 20 Insertions in Non-Small Cell Lung Cancer: Recent Advances and Clinical Updates. PMID:34301786
SPTAN1 Expression Predicts Treatment and Survival Outcomes in Colorectal Cancer. PMID:34298848
Tetranucleotide and Low Microsatellite Instability Are Inversely Associated with the CpG Island Methylator Phenotype in Colorectal Cancer. PMID:34298744
Explainable Artificial Intelligence Reveals Novel Insight into Tumor Microenvironment Conditions Linked with Better Prognosis in Patients with Breast Cancer. PMID:34298668
Methyltransferases in the Pathogenesis of Keratinocyte Cancers. PMID:34298617
circExp database: an online transcriptome platform for human circRNA expressions in cancers. PMID:34296749
KiRNet: Kinase-centered network propagation of pharmacological screen results. PMID:34296206
NEK7 Promotes Pancreatic Cancer Progression And Its Expression Is Correlated With Poor Prognosis. PMID:34295827
De novo and cell line models of human mammary cell transformation reveal an essential role for Yb-1 in multiple stages of human breast cancer. PMID:34294889
Expression patterns and prognostic value of RUNX genes in kidney cancer. PMID:34294773
The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas. PMID:34293822
Collagen XVII inhibits breast cancer cell proliferation and growth through deactivation of the AKT/mTOR signaling pathway. PMID:34293053
Autocrine signaling by receptor tyrosine kinases in urothelial carcinoma of the bladder. PMID:34292953
Liver-Metastasis-Related Genes are Potential Biomarkers for Predicting the Clinical Outcomes of Patients with Pancreatic Adenocarcinoma. PMID:34290570
Preoperative clinical and tumor genomic features associated with pathologic lymph node metastasis in clinical stage I and II lung adenocarcinoma. PMID:34290393
Identification of prognostic long non-coding RNA signature with potential drugs in hepatocellular carcinoma. PMID:34285143
Type 2 dendritic cells mediate control of cytotoxic T cell resistant tumors. PMID:34283809
Single Cell Genetic Profiling of Tumors of Breast Cancer Patients Aged 50 Years and Older Reveals Enormous Intratumor Heterogeneity Independent of Individual Prognosis. PMID:34282768
Pursuit of Gene Fusions in Daily Practice: Evidence from Real-World Data in Wild-Type and Microsatellite Instable Patients. PMID:34282766
Development of a Novel Immune Infiltration-Related ceRNA Network and Prognostic Model for Sarcoma. PMID:34277600
Comprehensive Transcriptomic Analysis Reveals the Role of the Immune Checkpoint HLA-G Molecule in Cancers. PMID:34276642
Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort. PMID:34276383
The Progenetix oncogenomic resource in 2021. PMID:34272855
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. PMID:34270926
A Robust Prognostic Gene Signature Based on eRNAs-Driven Genes in Prostate Cancer. PMID:34267780
KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype. PMID:34263179
A Platform for Validating Colorectal Cancer Driver Genes Using Mouse Organoids. PMID:34262603
Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortia. PMID:34262154
The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling. PMID:34262028
Epithelial Splicing Regulatory Protein 1 Is Overexpressed in Breast Cancer and Predicts Poor Prognosis for Breast Cancer Patients. PMID:34262011
Integrated digital pathology at scale: A solution for clinical diagnostics and cancer research at a large academic medical center. PMID:34260720
Accelerating precision medicine in metastatic prostate cancer. PMID:34258585
Notch1 Deficiency Induces Tumor Cell Accumulation Inside the Bronchiolar Lumen and Increases TAZ Expression in an Autochthonous Kras LSL-G12V Driven Lung Cancer Mouse Model. PMID:34257546
Expression, Prognosis and Gene Regulation Network of NFAT Transcription Factors in Non-Small Cell Lung Cancer. PMID:34257525
A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases. PMID:34253785
PathCNN: interpretable convolutional neural networks for survival prediction and pathway analysis applied to glioblastoma. PMID:34252964
OncoThreads: visualization of large-scale longitudinal cancer molecular data. PMID:34252935
Methylation silencing CDH23 is a poor prognostic marker in diffuse large B-cell lymphoma. PMID:34252883
Data mining-based study of collagen type III alpha 1 (COL3A1) prognostic value and immune exploration in pan-cancer. PMID:34252356
Exceptional Response to Trastuzumab in a Heavily Pretreated Patient With ERBB3-Mutated Metastatic Breast Cancer. PMID:34250408
Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer. PMID:34250404
Identification of Targetable Gene Fusions and Structural Rearrangements to Foster Precision Medicine in KRAS Wild-Type Pancreatic Cancer. PMID:34250383
Novel Markers in Pediatric Acute Lymphoid Leukemia: The Role of ADAM6 in B Cell Leukemia. PMID:34249950
Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer. PMID:34249755
TFPI2 Promotes Perivascular Migration in an Angiotropism Model of Melanoma. PMID:34249699
Association of CLDN6 and CLDN10 With Immune Microenvironment in Ovarian Cancer: A Study of the Claudin Family. PMID:34249076
Pan-Cancer Analysis Identifies Liver Metastases as Negative Predictive Factor for Immune Checkpoint Inhibitors Treatment Outcome. PMID:34248939
Bioinformatics analysis of the role of CXC ligands in the microenvironment of head and neck tumor. PMID:34247149
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine. PMID:34244484
Role of chromosome 1q copy number variation in hepatocellular carcinoma. PMID:34239701
Neuropilin-1: A feasible link between liver pathologies and COVID-19. PMID:34239266
Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells. PMID:34239121
Thioredoxin reductase is a major regulator of metabolism in leukemia cells. PMID:34239044
Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression. PMID:34237057
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis. PMID:34237033
Molecular Associations and Clinical Significance of RAPs in Hepatocellular Carcinoma. PMID:34235179
A miR-212-3p/SLC6A1 Regulatory Sub-Network for the Prognosis of Hepatocellular Carcinoma. PMID:34234551
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma. PMID:34231338
Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication. PMID:34228709
Prognostic and immunological value of ATP6AP1 in breast cancer: implications for SARS-CoV-2. PMID:34228637
Abnormal expression and methylation of PRR34-AS1 are associated with adverse outcomes in acute myeloid leukemia. PMID:34227248
Molecular basis for RASSF10/NPM/RNF2 feedback cascade-mediated regulation of gastric cancer cell proliferation. PMID:34224728
Bioinformatics Analysis of GFAP as a Potential Key Regulator in Different Immune Phenotypes of Prostate Cancer. PMID:34222466
CBX4 Provides an Alternate Mode of Colon Cancer Development via Potential Influences on Circadian Rhythm and Immune Infiltration. PMID:34222240
De Novo Mutation in Non-Tyrosine Kinase Domain of ROS1 as a Potential Predictor of Immune Checkpoint Inhibitors in Melanoma. PMID:34221982
A Novel Immune-Related Prognostic Signature in Head and Neck Squamous Cell Carcinoma. PMID:34220923
On the Use of Topological Features of Metabolic Networks for the Classification of Cancer Samples. PMID:34220296
The pattern of gene copy number alteration (CNAs) in hepatocellular carcinoma: an in silico analysis. PMID:34215297
eVIP2: Expression-based variant impact phenotyping to predict the function of gene variants. PMID:34214079
A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated prostate cancer. PMID:34211036
CACNA1C is a prognostic predictor for patients with ovarian cancer. PMID:34210324
Abnormal Long Non-Coding RNAs Expression Patterns Have the Potential Ability for Predicting Survival and Treatment Response in Breast Cancer. PMID:34209776
Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer. PMID:34209750
Integrative cBioPortal Analysis Revealed Molecular Mechanisms That Regulate EGFR-PI3K-AKT-mTOR Pathway in Diffuse Gliomas of the Brain. PMID:34209611
Regulatory SNPs: Altered Transcription Factor Binding Sites Implicated in Complex Traits and Diseases. PMID:34208629
Upper Aerodigestive Tract Squamous Cell Carcinomas Show Distinct Overall DNA Methylation Profiles and Different Molecular Mechanisms behind WNT Signaling Disruption. PMID:34208581
Evaluation of Darolutamide (ODM201) Efficiency on Androgen Receptor Mutants Reported to Date in Prostate Cancer Patients. PMID:34208290
DNA Methylation Markers from Negative Surgical Margins Can Predict Recurrence of Oral Squamous Cell Carcinoma. PMID:34207933
Clinicopathological Significance of Syndecan-1 in Cholangiocarcinoma: A Study Based on Immunohistochemistry and Public Sequencing Data. PMID:34206469
Gene Expression Profiles Associated with Radio-Responsiveness in Locally Advanced Rectal Cancer. PMID:34205090
Evaluation of Somatic Mutations in Solid Metastatic Pan-Cancer Patients. PMID:34204917
Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types. PMID:34202528
Multiplex Patient-Based Drug Response Assay in Pancreatic Ductal Adenocarcinoma. PMID:34201419
Integrative Transcriptomic Analysis Reveals Distinctive Molecular Traits and Novel Subtypes of Collecting Duct Carcinoma. PMID:34200770
Molecular Characterization of Muellerian Tumors of the Urinary Tract. PMID:34200508
Biphasic α2β1 Integrin Expression in Breast Cancer Metastasis to Bone. PMID:34199096
miRNA Clusters with Up-Regulated Expression in Colorectal Cancer. PMID:34198662
WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-κB activation. PMID:34197030
Comprehensive analysis of cytoskeleton regulatory genes identifies ezrin as a prognostic marker and molecular target in acute myeloid leukemia. PMID:34196912
Analyzing the influence of IL18 in regulation of YAP1 in breast oncogenesis using cBioportal. PMID:34196131
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. PMID:34192534
SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling. PMID:34187905
Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo. PMID:34187574
Functions and clinical significance of KLRG1 in the development of lung adenocarcinoma and immunotherapy. PMID:34187403
Identification of Endogenous Kinase Substrates by Proximity Labeling Combined with Kinase Perturbation and Phosphorylation Motifs. PMID:34186244
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation. PMID:34186021
HAI-1 is an independent predictor of lung cancer mortality and is required for M1 macrophage polarization. PMID:34185790
CRY2 missense mutations suppress P53 and enhance cell growth. PMID:34183418
A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis. PMID:34180355
Quantum processor-inspired machine learning in the biomedical sciences. PMID:34179840
ADHFE1 is a correlative factor of patient survival in cancer. PMID:34179501
MCM4 Is a Novel Biomarker Associated With Genomic Instability, BRCAness Phenotype, and Therapeutic Potentials in Soft-Tissue Sarcoma. PMID:34178990
Prevalence and Spectrum of Germline BRCA1 and BRCA2 Variants of Uncertain Significance in Breast/Ovarian Cancer: Mysterious Signals From the Genome. PMID:34178674
Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value. PMID:34178669
LpCat1 Promotes Malignant Transformation of Hepatocellular Carcinoma Cells by Directly Suppressing STAT1. PMID:34178664
The Gain-of-Function p53 R248W Mutant Promotes Migration by STAT3 Deregulation in Human Pancreatic Cancer Cells. PMID:34178628
p38β - MAPK11 and its role in female cancers. PMID:34174910
SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma. PMID:34173014
A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma. PMID:34172930
MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancer. PMID:34172788
The clinical and molecular significance associated with STING signaling in breast cancer. PMID:34172750
COVID-19 and Malignancy: Exploration of the possible genetic and epigenetic interlinks and overview of the vaccination scenario. PMID:34171559
Regulation of CD47 expression by interferon-gamma in cancer cells. PMID:34171557
Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity. PMID:34171264
SLC15A4 Serves as a Novel Prognostic Biomarker and Target for Lung Adenocarcinoma. PMID:34168674
Molecular alterations in basal cell carcinoma subtypes. PMID:34168209
RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer. PMID:34168046
HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML. PMID:34167558
A comprehensive database for integrated analysis of omics data in autoimmune diseases. PMID:34167460
SLC7A5 serves as a prognostic factor of breast cancer and promotes cell proliferation through activating AKT/mTORC1 signaling pathway. PMID:34164526
Earlier extracranial progression and shorter survival in ALK-rearranged lung cancer with positive liquid rebiopsies. PMID:34164264
Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors. PMID:34163353
Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia. PMID:34162911
CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents. PMID:34161330
Insights of fibroblast growth factor receptor 3 aberrations in pan-cancer and their roles in potential clinical treatment. PMID:34160364
Long-term disease control and survival observed after stereotactic ablative body radiotherapy for oligometastatic breast cancer. PMID:34159748
CALM supports clathrin-coated vesicle completion upon membrane tension increase. PMID:34155137
Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK-YAP Signaling. PMID:34151545
ALKBH1-8 and FTO: Potential Therapeutic Targets and Prognostic Biomarkers in Lung Adenocarcinoma Pathogenesis. PMID:34150745
Expression status and prognostic value of the perilipin family of genes in breast cancer. PMID:34150026
Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells. PMID:34149804
TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma. PMID:34148105
Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. PMID:34145784
Fatty Acid Synthesis in Prostate Cancer: Vulnerability or Epiphenomenon? PMID:34145040
E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer. PMID:34145034
Online database for brain cancer-implicated genes: exploring the subtype-specific mechanisms of brain cancer. PMID:34144671
p85β alters response to EGFR inhibitor in ovarian cancer through p38 MAPK-mediated regulation of DNA repair. PMID:34144267
E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer. PMID:34143182
Construction of a Myc-associated ceRNA network reveals a prognostic signature in hepatocellular carcinoma. PMID:34141458
DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma. PMID:34140574
Erlotinib and Onalespib Lactate Focused on EGFR Exon 20 Insertion Non-Small Cell Lung Cancer (NSCLC): A California Cancer Consortium Phase I/II Trial (NCI 9878). PMID:34140248
Whole-Exome Sequencing Analysis of Oral Squamous Cell Carcinoma Delineated by Tobacco Usage Habits. PMID:34136393
Making fundamental scientific discoveries by combining information from literature, databases, and computational tools - An example. PMID:34136100
Mutant p53s and chromosome 19 microRNA cluster overexpression regulate cancer testis antigen expression and cellular transformation in hepatocellular carcinoma. PMID:34135394
Immunotherapy in endometrial cancer: rationale, practice and perspectives. PMID:34134781
Telomere Attrition and p53 Response 1 (TAPR1): a new player in cancer biology? PMID:34133663
The role of RB1 alteration and 4q12 amplification in IDH-WT glioblastoma. PMID:34131647
Adipogenesis in triple-negative breast cancer is associated with unfavorable tumor immune microenvironment and with worse survival. PMID:34131208
Absent in melanoma 1-like (AIM1L) serves as a novel candidate for overall survival in hepatocellular carcinoma. PMID:34130591
Copy number alterations identify a smoking-associated expression signature predictive of poor outcome in head and neck squamous cell carcinoma. PMID:34130230
Molecular classification and diagnostics of upper urinary tract urothelial carcinoma. PMID:34129823
Immune infiltration phenotypes of prostate adenocarcinoma and their clinical implications. PMID:34128342
Immu-Mela: An open resource for exploring immunotherapy-related multidimensional genomic profiles in melanoma. PMID:34127402
In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function. PMID:34125870
Establishment of Novel Prostate Cancer Risk Subtypes and A Twelve-Gene Prognostic Model. PMID:34124157
IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment. PMID:34123844
Highly connected, non-redundant microRNA functional control in breast cancer molecular subtypes. PMID:34123357
METTL14 Acts as a Potential Regulator of Tumor Immune and Progression in Clear Cell Renal Cell Carcinoma. PMID:34122497
PSMA radioligand therapy for solid tumors other than prostate cancer: background, opportunities, challenges, and first clinical reports. PMID:34120192
The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer. PMID:34118960
Oncogene-regulated release of extracellular vesicles. PMID:34118203
Identification of a Novel Inflamed Tumor Microenvironment Signature as a Predictive Biomarker of Bacillus Calmette-Guérin Immunotherapy in Non-Muscle-Invasive Bladder Cancer. PMID:34117034
Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation. PMID:34116687
Identification of potential diagnostic biomarkers in MMPs for pancreatic carcinoma. PMID:34114996
A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma. PMID:34114970
Human Gastric Cancer Stem Cell (GCSC) Markers Are Prognostic Factors Correlated With Immune Infiltration of Gastric Cancer. PMID:34113647
A Bioinformatics Analysis of the Potential Roles of Aquaporin 4 in Human Brain Tumors: An Immune-Related Process. PMID:34113257
Hyaluronan-mediated motility receptor expression functions as a prognostic biomarker in uterine carcinosarcoma based on bioinformatics analysis. PMID:34111996
Expression pattern and prognostic impact of glycoprotein non-metastatic B (GPNMB) in triple-negative breast cancer. PMID:34108545
Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer. PMID:34108519
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer. PMID:34108441
Heterogeneity in NECTIN4 Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin. PMID:34108177
STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR/MAPK signaling pathway. PMID:34102455
FOXA1 overexpression suppresses interferon signaling and immune response in cancer. PMID:34101624
Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer. PMID:34100918
Alterations in the RTK/Ras/PI3K/AKT pathway serve as potential biomarkers for immunotherapy outcome of diffuse gliomas. PMID:34100771
Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer. PMID:34099734
Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma. PMID:34097975
Integrating Somatic and Germline Next-Generation Sequencing Into Routine Clinical Oncology Practice. PMID:34095711
ITGA3 Is Associated With Immune Cell Infiltration and Serves as a Favorable Prognostic Biomarker for Breast Cancer. PMID:34094951
High Expression of RhoBTB3 Predicts Favorable Chemothrapy Outcomes in non-M3 Acute Myeloid Leukemia. PMID:34093823
Glyoxalase 1 and protein kinase Cλ as potential therapeutic targets for late-stage breast cancer. PMID:34093768
Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM). PMID:34088988
CXCL2/10/12/14 are prognostic biomarkers and correlated with immune infiltration in hepatocellular carcinoma. PMID:34085699
A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance. PMID:34085047
Mice with dysfunctional TGF-β signaling develop altered intestinal microbiome and colorectal cancer resistant to 5FU. PMID:34082069
MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF. PMID:34079078
The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51. PMID:34077419
ENTPD5: identification of splicing variants and their impact on cancer survival. PMID:34075526
A mosaic PIK3CA variant in a young adult with diffuse gastric cancer: case report. PMID:34075207
Pan-cancer analysis of the prognostic value of C12orf75 based on data mining. PMID:34074799
Epithelial-Mesenchymal Transition Gene Signature Related to Prognostic in Colon Adenocarcinoma. PMID:34073426
In-Silico Evaluation of Genetic Alterations in Ovarian Carcinoma and Therapeutic Efficacy of NSC777201, as a Novel Multi-Target Agent for TTK, NEK2, and CDK1. PMID:34072728
PERK/ATF4-Dependent ZFAS1 Upregulation Is Associated with Sorafenib Resistance in Hepatocellular Carcinoma Cells. PMID:34072570
LncRNA PART1 Promotes Proliferation and Migration, Is Associated with Cancer Stem Cells, and Alters the miRNA Landscape in Triple-Negative Breast Cancer. PMID:34072264
Multi-Omics Model Applied to Cancer Genetics. PMID:34072237
Targeting Natural Killer T Cells in Solid Malignancies. PMID:34072042
Enhanced Thermogenesis in Triple-Negative Breast Cancer Is Associated with Pro-Tumor Immune Microenvironment. PMID:34071012
Survival-Critical Genes Associated with Copy Number Alterations in Lung Adenocarcinoma. PMID:34070461
A Keratin 7 and E-Cadherin Signature Is Highly Predictive of Tubo-Ovarian High-Grade Serous Carcinoma Prognosis. PMID:34070214
Prognostic Role of Immune Checkpoint Regulators in Cholangiocarcinoma: A Pilot Study. PMID:34069452
Regulation of the Phosphoinositide Code by Phosphorylation of Membrane Readers. PMID:34069055
Sequence Neighborhoods Enable Reliable Prediction of Pathogenic Mutations in Cancer Genomes. PMID:34068918
ELTD1-An Emerging Silent Actor in Cancer Drama Play. PMID:34068040
Molecular Mechanisms of PD-1 and PD-L1 Activity on a Pan-Cancer Basis: A Bioinformatic Exploratory Study. PMID:34067485
LIMK2-NKX3.1 Engagement Promotes Castration-Resistant Prostate Cancer. PMID:34066036
Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics. PMID:34065652
A Novel Three-Gene Score as a Predictive Biomarker for Pathologically Complete Response after Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer. PMID:34065619
Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells-Relevance for Understanding (Germ Cell) Tumorigenesis. PMID:34065345
RLIP76: A Structural and Functional Triumvirate. PMID:34064388
High glucose induced c-Met activation promotes aggressive phenotype and regulates expression of glucose metabolism genes in HCC cells. PMID:34059694
SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA-deficient cells. PMID:34058059
Utilizing Publicly Available Cancer Clinicogenomic Data on CBioPortal to Compare Epidermal Growth Factor Receptor Mutant and Wildtype Non-Small Cell Lung Cancer. PMID:34055528
A case series of extraneural metastatic glioblastoma at Memorial Sloan Kettering Cancer Center. PMID:34055380
Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis. PMID:34052835
OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis. PMID:34050636
Amplification of RAD54B promotes progression of hepatocellular carcinoma via activating the Wnt/β-catenin signaling. PMID:34049150
Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer. PMID:34047812
Recurrent Somatic MAP2K1 Mutations in Papillary Thyroid Cancer and Colorectal Cancer. PMID:34046359
Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma. PMID:34045512
MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer. PMID:34045467
The effects of ARID1A mutations on colorectal cancer and associations with PD-L1 expression by stromal cells. PMID:34042312
Identification of prognostic and bone metastasis-related alternative splicing signatures in mesothelioma. PMID:34041868
Somatic PIK3R1 variation as a cause of vascular malformations and overgrowth. PMID:34040190
High Response Rate and Durability Driven by HLA Genetic Diversity in Patients with Kidney Cancer Treated with Lenvatinib and Pembrolizumab. PMID:34039647
TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models. PMID:34039392
Cancer cell metabolism connects epigenetic modifications to transcriptional regulation. PMID:34036737
Increased expression of KPNA2 predicts unfavorable prognosis in ovarian cancer patients, possibly by targeting KIF4A signaling. PMID:34034774
Transcription Factor-Binding Site Identification and Enrichment Analysis. PMID:34033108
Mammary epithelial cells have lineage-rooted metabolic identities. PMID:34031589
Improved methods for RNAseq-based alternative splicing analysis. PMID:34031440
In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy. PMID:34031411
driveR: a novel method for prioritizing cancer driver genes using somatic genomics data. PMID:34030627
Identification of combinations of somatic mutations that predict cancer survival and immunotherapy benefit. PMID:34027407
MLH1 Deficiency Down-Regulates TLR4 Expression in Sporadic Colorectal Cancer. PMID:34026821
CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway. PMID:34026424
Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma. PMID:34025662
Role of the ABL tyrosine kinases in the epithelial-mesenchymal transition and the metastatic cascade. PMID:34022881
Upregulated functional gene expression programmes in tumour pericytes mark progression in patients with low-grade glioma. PMID:34018679
Hub biomarkers for the diagnosis and treatment of glioblastoma based on microarray technology. PMID:34018447
Mutation and Copy Number Alterations Analysis of KIF23 in Glioma. PMID:34017355
Mutational signatures impact the evolution of anti-EGFR antibody resistance in colorectal cancer. PMID:34017094
Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer. PMID:34016083
Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma. PMID:34015961
Obscurin: A multitasking giant in the fight against cancer. PMID:34015411
Role of ZBTB7A zinc finger in tumorigenesis and metastasis. PMID:34014468
The Role of Neurodevelopmental Pathways in Brain Tumors. PMID:34012965
Genomic evolutionary trajectory of metastatic squamous cell carcinoma of the lung. PMID:34012793
The roles of the cell division cycle-associated gene family in hepatocellular carcinoma. PMID:34012666
Comprehensive analysis of the prognostic value of the chemokine-like factor-like MARVEL transmembrane domain-containing family in gastric cancer. PMID:34012634
Expression and prognostic significance of thrombospondin gene family in gastric cancer. PMID:34012631
Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer. PMID:34011995
β-arrestin 2 stimulates degradation of HIF-1α and modulates tumor progression of glioblastoma. PMID:34007068
Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure. PMID:34003820
Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1. PMID:34003553
Downregulation of USP18 reduces tumor-infiltrating activated dendritic cells in extranodal diffuse large B cell lymphoma patients. PMID:34001679
The Role of Fibroblast Growth Factor 19 in Hepatocellular Carcinoma. PMID:34000282
Diagnostic, Therapeutic, and Prognostic Value of the Thrombospondin Family in Gastric Cancer. PMID:33996903
Chaperonin-Containing TCP1 Complex (CCT) Promotes Breast Cancer Growth Through Correlations With Key Cell Cycle Regulators. PMID:33996588
MTFR2, A Potential Biomarker for Prognosis and Immune Infiltrates, Promotes Progression of Gastric Cancer Based on Bioinformatics Analysis and Experiments. PMID:33995638
Extracellular Vesicles: A Novel Tool Facilitating Personalized Medicine and Pharmacogenomics in Oncology. PMID:33995103
Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer. PMID:33993095
Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response. PMID:33992077
Enabling Precision Medicine in Cancer Care Through a Molecular Data Warehouse: The Moffitt Experience. PMID:33989014
The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription-replication conflicts. PMID:33986538
FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036. PMID:33980863
Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion. PMID:33980181
BRAFnon-V600E more frequently co-occurs with IDH1/2 mutations in adult patients with gliomas than in patients harboring BRAFV600E but without a survival advantage. PMID:33980169
Expression Pattern and Prognostic Value of EPHA/EFNA in Breast Cancer by Bioinformatics Analysis: Revealing Its Importance in Chemotherapy. PMID:33977106
Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy. PMID:33976322
Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly. PMID:33976187
EGR1/2 Inhibits Papillary Thyroid Carcinoma Cell Growth by Suppressing the Expression of PTEN and BAX. PMID:33973090
Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence. PMID:33972599
Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes. PMID:33972523
Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas. PMID:33972520
AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer. PMID:33972443
Discovery of Candidate DNA Methylation Cancer Driver Genes. PMID:33972312
Knowledge bases and software support for variant interpretation in precision oncology. PMID:33971666
Validation of the functions and prognostic values of synapse-associated proteins in lower-grade glioma. PMID:33969375
Expression pattern of histone lysine-specific demethylase 6B in gastric cancer. PMID:33968207
Neutrophil Elastase Defects in Congenital Neutropenia. PMID:33968054
HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers. PMID:33966634
RFX1: a promising therapeutic arsenal against cancer. PMID:33964962
Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461. PMID:33963218
Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period. PMID:33963205
Intrahepatic Cholangiocarcinoma with Lymph Node Metastasis: Treatment-Related Outcomes and the Role of Tumor Genomics in Patient Selection. PMID:33963001
EARN: an ensemble machine learning algorithm to predict driver genes in metastatic breast cancer. PMID:33962648
A prognostic model based on seven immune-related genes predicts the overall survival of patients with hepatocellular carcinoma. PMID:33962640
Prognostic value of members of NFAT family for pan-cancer and a prediction model based on NFAT2 in bladder cancer. PMID:33962392
Evaluation of BRCA1 and BRCA2 as Indicators of Response to Immune Checkpoint Inhibitors. PMID:33961040
Analysis of the EGFR Amplification and CDKN2A Deletion Regulated Transcriptomic Signatures Reveals the Prognostic Significance of SPATS2L in Patients With Glioma. PMID:33959491
Developing Precision Medicine for Bladder Cancer. PMID:33958155
Systematic interrogation of mutation groupings reveals divergent downstream expression programs within key cancer genes. PMID:33957863
Smoothened loss is a characteristic of neuroendocrine prostate cancer. PMID:33955576
Predictive Value of KDM5C Alterations for Immune Checkpoint Inhibitors Treatment Outcomes in Patients With Cancer. PMID:33953726
SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site. PMID:33953332
Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes. PMID:33947695
S100A4 Is Involved in Stimulatory Effects Elicited by the FGF2/FGFR1 Signaling Pathway in Triple-Negative Breast Cancer (TNBC) Cells. PMID:33946884
Genomic Characterization of Concurrent Alterations in Non-Small Cell Lung Cancer (NSCLC) Harboring Actionable Mutations. PMID:33946519
Targeting epigenetic mechanisms to overcome venetoclax resistance. PMID:33945824
CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer. PMID:33945523
The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling. PMID:33941855
Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy. PMID:33941852
Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer. PMID:33937026
Advances of Fibroblast Growth Factor/Receptor Signaling Pathway in Hepatocellular Carcinoma and its Pharmacotherapeutic Targets. PMID:33935756
SMYD2 promotes tumorigenesis and metastasis of lung adenocarcinoma through RPS7. PMID:33935284
Comprehensive analysis of prognostic value and immune infiltration of kindlin family members in non-small cell lung cancer. PMID:33934696
MRPL15 is a novel prognostic biomarker and therapeutic target for epithelial ovarian cancer. PMID:33934540
Prostate cancer patient-derived organoids: detailed outcome from a prospective cohort of 81 clinical specimens. PMID:33934365
Targeting the PI3K and MAPK pathways to improve response to HER2-targeted therapies in HER2-positive gastric cancer. PMID:33933113
Identification of inhibitory immune checkpoints and relevant regulatory pathways in breast cancer stem cells. PMID:33932112
Mutant KRAS Downregulates the Receptor for Leukemia Inhibitory Factor (LIF) to Enhance a Signature of Glycolysis in Pancreatic Cancer and Lung Cancer. PMID:33931487
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer. PMID:33931024
Control of Breast Cancer Pathogenesis by Histone Methylation and the Hairless Histone Demethylase. PMID:33928351
Four Novel Prognostic Genes Related to Prostate Cancer Identified Using Co-expression Structure Network Analysis. PMID:33927744
MGA Mutation as a Novel Biomarker for Immune Checkpoint Therapies in Non-Squamous Non-Small Cell Lung Cancer. PMID:33927616
Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort. PMID:33927264
Ten-eleven translocation protein 1 modulates medulloblastoma progression. PMID:33926529
Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex. PMID:33925740
Genomic Correlates of DNA Damage in Breast Cancer Subtypes. PMID:33925616
LAG-3 Blockade with Relatlimab (BMS-986016) Restores Anti-Leukemic Responses in Chronic Lymphocytic Leukemia. PMID:33925565
ING Proteins: Tumour Suppressors or Oncoproteins. PMID:33925563
The Role of Wild-Type RAS in Oncogenic RAS Transformation. PMID:33924994
The ECM Modulator ITIH5 Affects Cell Adhesion, Motility and Chemotherapeutic Response of Basal/Squamous-Like (BASQ) Bladder Cancer Cells. PMID:33924987
The Role of p53 Signaling in Colorectal Cancer. PMID:33924934
KLF5 Is Activated by Gene Amplification in Gastric Cancer and Is Essential for Gastric Cell Proliferation. PMID:33923166
PRKCA Overexpression Is Frequent in Young Oral Tongue Squamous Cell Carcinoma Patients and Is Associated with Poor Prognosis. PMID:33923093
Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. PMID:33922599
The Emerging Clinical Role of Spermine in Prostate Cancer. PMID:33922247
A Bioinformatics Analysis Identifies the Telomerase Inhibitor MST-312 for Treating High-STMN1-Expressing Hepatocellular Carcinoma. PMID:33922244
MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model. PMID:33921698
The Expression Regulation and Biological Function of Autotaxin. PMID:33921676
Melanoma Associated Chitinase 3-Like 1 Promoted Endothelial Cell Activation and Immune Cell Recruitment. PMID:33920100
RNA Expression of DNA Damage Response Genes in Muscle-Invasive Bladder Cancer: Influence on Outcome and Response to Adjuvant Cisplatin-Based Chemotherapy. PMID:33919527
Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses. PMID:33918976
Neuropilin-2 and Its Transcript Variants Correlate with Clinical Outcome in Bladder Cancer. PMID:33918816
Loss of the Metastasis Suppressor NME1, But Not of Its Highly Related Isoform NME2, Induces a Hybrid Epithelial-Mesenchymal State in Cancer Cells. PMID:33918324
CK2 Activity Mediates the Aggressive Molecular Signature of Glioblastoma Multiforme by Inducing Nerve/Glial Antigen (NG)2 Expression. PMID:33918235
Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer. PMID:33918004
The rs599839 A>G Variant Disentangles Cardiovascular Risk and Hepatocellular Carcinoma in NAFLD Patients. PMID:33917919
Tumor Signature Analysis Implicates Hereditary Cancer Genes in Endometrial Cancer Development. PMID:33917078
Neurological Disorders Associated with WWOX Germline Mutations-A Comprehensive Overview. PMID:33916893
Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation. PMID:33916378
Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors. PMID:33914855
Identification of Expression Patterns and Potential Prognostic Significance of m5C-Related Regulators in Head and Neck Squamous Cell Carcinoma. PMID:33912441
A New Insight for the Identification of Oncogenic Variants in Breast and Prostate Cancers in Diverse Human Populations, With a Focus on Latinos. PMID:33912047
Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities. PMID:33910596
Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action. PMID:33909629
Diffuse midline glioma with H3 K27M-mutation in an 83-year-old woman. PMID:33908265
ARHGAP20 Expression Inhibited HCC Progression by Regulating the PI3K-AKT Signaling Pathway. PMID:33907697
The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells. PMID:33907253
Prostate epithelial genes define therapy-relevant prostate cancer molecular subtype. PMID:33903734
The lncRNA GATA3-AS1/miR-495-3p/CENPU axis predicts poor prognosis of breast cancer via the PLK1 signaling pathway. PMID:33902008
Identification of Epithelial-Mesenchymal Transition-Related lncRNAs that Associated With the Prognosis and Immune Microenvironment in Colorectal Cancer. PMID:33898515
Study on the Prognostic Values of Dynactin Genes in Low-Grade Glioma. PMID:33896271
Update on genomic and molecular landscapes of well-differentiated liposarcoma and dedifferentiated liposarcoma. PMID:33893924
Prognostic biomarkers and therapeutic targets in oral squamous cell carcinoma: a study based on cross-database analysis. PMID:33892811
The converging roles of Batten disease proteins in neurodegeneration and cancer. PMID:33889828
HER2 transmembrane domain mutation: comprehensive characteristics and real-world evidence of treatment response in Chinese lung adenocarcinoma. PMID:33889517
Predicting clinical outcomes using cancer progression associated signatures. PMID:33889305
Up to your NEK2 in CIN. PMID:33889296
Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens. PMID:33888849
Surface Expression of Kynurenine 3-Monooxygenase Promotes Proliferation and Metastasis in Triple-Negative Breast Cancers. PMID:33887987
Epidermal growth factor receptor regulates fibrinolytic pathway elements in cervical cancer: functional and prognostic implications. PMID:33886813
Impact of splicing mutations in acute myeloid leukemia treated with hypomethylating agents combined with venetoclax. PMID:33885753
Gene Expression and Data Analysis Pipeline Using Cancer BioPortal in the Classroom. PMID:33884053
Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer. PMID:33883167
CDC20 and PTTG1 are Important Biomarkers and Potential Therapeutic Targets for Metastatic Prostate Cancer. PMID:33881746
PTEN mutations predict benefit from tumor treating fields (TTFields) therapy in patients with recurrent glioblastoma. PMID:33881725
Bioinformatics and In Vitro Studies Reveal the Importance of p53, PPARG and Notch Signaling Pathway in Inhibition of Breast Cancer Stem Cells by Hesperetin. PMID:33880358
MicroRNA-302s Might Regulate ARL4C-Mediated Gastric Cancer Progression via p53 Signaling: Bioinformatics Analysis and Experiments Validation. PMID:33880033
Identification of prognostic biomarkers associated with the occurrence of portal vein tumor thrombus in hepatocellular carcinoma. PMID:33878734
14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia. PMID:33876209
High estrogen receptor alpha activation confers resistance to estrogen deprivation and is required for therapeutic response to estrogen in breast cancer. PMID:33875787
SPRED proteins and their roles in signal transduction, development, and malignancy. PMID:33872193
The Metabolic Landscape of RAS-Driven Cancers from biology to therapy. PMID:33870211
A Non-canonical Wnt Signature Correlates With Lower Survival in Gastric Cancer. PMID:33869179
LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton. PMID:33869174
Mutated DNA Damage Repair Pathways Are Prognostic and Chemosensitivity Markers for Resected Colorectal Cancer Liver Metastases. PMID:33869034
Algorithm-Based Meta-Analysis Reveals the Mechanistic Interaction of the Tumor Suppressor LIMD1 With Non-Small-Cell Lung Carcinoma. PMID:33869018
CD80 expression is upregulated by TP53 activation in human cancer epithelial cells. PMID:33868791
DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression. PMID:33868478
Cytotoxic T-lymphocyte infiltration and chemokine predict long-term patient survival independently of tumor mutational burden in triple-negative breast cancer. PMID:33868461
RRM2B Is Frequently Amplified Across Multiple Tumor Types: Implications for DNA Repair, Cellular Survival, and Cancer Therapy. PMID:33868369
IκBα targeting promotes oxidative stress-dependent cell death. PMID:33863364
A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial. PMID:33862582
CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells. PMID:33861751
Comparison of metastatic castration-resistant prostate cancer in bone with other sites: clinical characteristics, molecular features and immune status. PMID:33859877
FCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress. PMID:33859174
Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis. PMID:33859162
The dystonia gene THAP1 controls DNA double-strand break repair choice. PMID:33857404
CRL4AMBRA1 is a master regulator of D-type cyclins. PMID:33854235
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. PMID:33854232
Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer. PMID:33853832
Metformin impairs cisplatin resistance effects in A549 lung cancer cells through mTOR signaling and other metabolic pathways. PMID:33846781
MAP3K7 Loss Drives Enhanced Androgen Signaling and Independently Confers Risk of Recurrence in Prostate Cancer with Joint Loss of CHD1. PMID:33846123
A cell-to-patient machine learning transfer approach uncovers novel basal-like breast cancer prognostic markers amongst alternative splice variants. PMID:33845831
Relationship of HER2 Alteration and Microsatellite Instability Status in Colorectal Adenocarcinoma. PMID:33844372
Epigenetic and metabolic interplay in cutaneous squamous cell carcinoma. PMID:33844325
Upregulation of GNPNAT1 Predicts Poor Prognosis and Correlates With Immune Infiltration in Lung Adenocarcinoma. PMID:33842535
mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 Are Druggable Candidates for N-(2,4-Difluorophenyl)-2',4'-Difluoro-4-Hydroxybiphenyl-3-Carboxamide (NSC765598), With Consequent Anticancer Implications. PMID:33842373
Colony Stimulating Factor 1 Receptor in Acute Myeloid Leukemia. PMID:33842370
CDKN2A Deletion in Melanoma Excludes T Cell Infiltration by Repressing Chemokine Expression in a Cell Cycle-Dependent Manner. PMID:33842347
Potential targets identified in adenoid cystic carcinoma point out new directions for further research. PMID:33841642
Nuclear factor IB is downregulated in vulvar squamous cell carcinoma (VSCC): Unravelling differentially expressed genes in VSCC through gene expression dataset analysis. PMID:33841565
Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma. PMID:33840169
Beyond Programmed Death-Ligand 1: B7-H6 Emerges as a Potential Immunotherapy Target in SCLC. PMID:33839362
BMP9-ID1 signaling promotes EpCAM-positive cancer stem cell properties in hepatocellular carcinoma. PMID:33834612
Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy. PMID:33834176
Whole-exome sequencing reveals the etiology of the rare primary hepatic mucoepidermoid carcinoma. PMID:33832503
Pan-genomic characterization of high-risk pediatric papillary thyroid carcinoma. PMID:33827048
Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors. PMID:33826903
Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapy. PMID:33822841
Vitamin D receptor upregulates lncRNA TOPORS-AS1 which inhibits the Wnt/β-catenin pathway and associates with favorable prognosis of ovarian cancer. PMID:33820921
A bioinformatic analysis of the inhibin-betaglycan-endoglin/CD105 network reveals prognostic value in multiple solid tumors. PMID:33819300
ORN: Inferring patient-specific dysregulation status of pathway modules in cancer with OR-gate Network. PMID:33819263
Growth Hormone/Insulin Growth Factor Axis in Sex Steroid Associated Disorders and Related Cancers. PMID:33816477
Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first-line platinum chemotherapy in high grade serous ovarian cancer. PMID:33811746
Constitutional 2p16.3 deletion including MSH6 and FBXO11 in a boy with developmental delay and diffuse large B-cell lymphoma. PMID:33811277
The Association between TIF1 Family Members and Cancer Stemness in Solid Tumors. PMID:33810347
Prognostic and Functional Significant of Heat Shock Proteins (HSPs) in Breast Cancer Unveiled by Multi-Omics Approaches. PMID:33810095
The Extracellular Small Leucine-Rich Proteoglycan Biglycan Is a Key Player in Gastric Cancer Aggressiveness. PMID:33809543
Aberrations of Chromosomes 1 and 16 in Breast Cancer: A Framework for Cooperation of Transcriptionally Dysregulated Genes. PMID:33808143
The CXCL2/IL8/CXCR2 Pathway Is Relevant for Brain Tumor Malignancy and Endothelial Cell Function. PMID:33807899
More Than Meets the Eye: Revisiting the Roles of Heat Shock Factor 4 in Health and Diseases. PMID:33807297
Gene Co-Expression Analysis of Human RNASEH2A Reveals Functional Networks Associated with DNA Replication, DNA Damage Response, and Cell Cycle Regulation. PMID:33805806
Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development-Review. PMID:33805800
Candidate Markers of Olaparib Response from Genomic Data Analyses of Human Cancer Cell Lines. PMID:33803939
The MEK1/2 Pathway as a Therapeutic Target in High-Grade Serous Ovarian Carcinoma. PMID:33803586
CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma. PMID:33803245
The Case for GNMT as a Biomarker and a Therapeutic Target in Pancreatic Cancer. PMID:33802396
A Detailed Catalogue of Multi-Omics Methodologies for Identification of Putative Biomarkers and Causal Molecular Networks in Translational Cancer Research. PMID:33802234
Linking Serine/Glycine Metabolism to Radiotherapy Resistance. PMID:33801846
Crk and CrkL as Therapeutic Targets for Cancer Treatment. PMID:33801580
Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis. PMID:33801331
Pathogenic Roles of S100A8 and S100A9 Proteins in Acute Myeloid and Lymphoid Leukemia: Clinical and Therapeutic Impacts. PMID:33801279
The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases. PMID:33800554
Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer. PMID:33799592
Androgen receptor signalling confers clonogenic and migratory advantages in urothelial cell carcinoma of the bladder. PMID:33797847
An In Silico Analysis Identified FZD9 as a Potential Prognostic Biomarker in Triple-Negative Breast Cancer Patients. PMID:33796830
Integrative Analysis of the Expression of SIGLEC Family Members in Lung Adenocarcinoma via Data Mining. PMID:33796453
Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer. PMID:33796412
Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways. PMID:33795256
The m6A Reader YTHDF1 Facilitates the Tumorigenesis and Metastasis of Gastric Cancer via USP14 Translation in an m6A-Dependent Manner. PMID:33791305
CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment. PMID:33791155
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. PMID:33789117
Viruses, cancer and non-self recognition. PMID:33784856
Expanding the genotypic and phenotypic spectrum in a diverse cohort of 104 individuals with Wiedemann-Steiner syndrome. PMID:33783954
Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis. PMID:33783919
Biochemical and structural characterization of analogs of MRE11 breast cancer-associated mutant F237C. PMID:33782469
PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion. PMID:33775697
Immune modulation underpins the anti-cancer activity of HDAC inhibitors. PMID:33773029
FUNGI: Fusion Gene Integration Toolset. PMID:33772596
Interferon regulatory factor 1 (IRF-1) downregulates Checkpoint kinase 1 (CHK1) through miR-195 to upregulate apoptosis and PD-L1 expression in Hepatocellular carcinoma (HCC) cells. PMID:33772151
CENP-A overexpression promotes distinct fates in human cells, depending on p53 status. PMID:33772115
The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer. PMID:33772001
Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity. PMID:33768207
Minerva: a light-weight, narrative image browser for multiplexed tissue images. PMID:33768192
Does Subtelomeric Position of COMMD5 Influence Cancer Progression? PMID:33768002
Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation. PMID:33767702
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway. PMID:33767426
A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells. PMID:33763657
Pan-cancer image-based detection of clinically actionable genetic alterations. PMID:33763651
High KIFC1 expression is associated with poor prognosis in prostate cancer. PMID:33760984
Single-cell analysis reveals metastatic cell heterogeneity in clear cell renal cell carcinoma. PMID:33759378
CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation. PMID:33758365
Overexpression of CCNE1 confers a poorer prognosis in triple-negative breast cancer identified by bioinformatic analysis. PMID:33757543
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. PMID:33756106
Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer. PMID:33756102
LIN28B induces a differentiation program through CDX2 in colon cancer. PMID:33755595
In search for biomarkers and potential drug targets for uterine serous endometrial cancer. PMID:33754208
The origins and genetic interactions of KRAS mutations are allele- and tissue-specific. PMID:33753749
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis. PMID:33753739
Integrated bioinformatic analysis of HNF1A in human cancers. PMID:33752475
The NFIB-ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells. PMID:33751828
NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer. PMID:33750924
A noncanonical AR addiction drives enzalutamide resistance in prostate cancer. PMID:33750801
Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer. PMID:33750350
Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function. PMID:33749663
Immune Modeling Analysis Reveals Immunologic Signatures Associated With Improved Outcomes in High Grade Serous Ovarian Cancer. PMID:33747935
Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma. PMID:33747576
miR-130a-3p promotes cell proliferation and invasion by targeting estrogen receptor α and androgen receptor in cervical cancer. PMID:33747155
Cutaneous Melanoma: Mutational Status and Potential Links to Tertiary Lymphoid Structure Formation. PMID:33746966
Aberrations in circulating ceramide levels are associated with poor clinical outcomes across localised and metastatic prostate cancer. PMID:33746214
Expression and molecular profiles of the AlkB family in ovarian serous carcinoma. PMID:33744868
Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis. PMID:33743547
Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis. PMID:33742106
Swiss-PO: a new tool to analyze the impact of mutations on protein three-dimensional structures for precision oncology. PMID:33737716
TFEB Promotes Prostate Cancer Progression via Regulating ABCA2-Dependent Lysosomal Biogenesis. PMID:33732651
A survey of cancer genome signatures identifies genes connected to distinct chromosomal instability phenotypes. PMID:33731882
Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer. PMID:33731859
Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress. PMID:33731803
Expression and prognosis analysis of GINS subunits in human breast cancer. PMID:33725952
Characterization of genetics in patients with mucosal melanoma treated with immune checkpoint blockade. PMID:33724703
Molecular features of untreated breast cancer and initial metastatic event inform clinical decision-making and predict outcome: long-term results of ESOPE, a single-arm prospective multicenter study. PMID:33722295
Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive (IDHwt) glioma is associated with H3K27me3 depletion and alternative promoter usage. PMID:33720519
G6PD-NF-κB-HGF Signal in Gastric Cancer-Associated Mesenchymal Stem Cells Promotes the Proliferation and Metastasis of Gastric Cancer Cells by Upregulating the Expression of HK2. PMID:33718248
Tumor Molecular Features Predict Endometrial Cancer Patients' Survival After Open or Minimally Invasive Surgeries. PMID:33718224
DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells. PMID:33718139
Identification of a novel immune-related microRNA prognostic model in clear cell renal cell carcinoma. PMID:33718090
Programmed death-ligand 1 expression level as a predictor of EGFR tyrosine kinase inhibitor efficacy in lung adenocarcinoma. PMID:33718015
Do Molecular Profiles of Primary Versus Metastatic Radioiodine Refractory Differentiated Thyroid Cancer Differ? PMID:33716974
SWI/SNF chromatin remodeling complex alterations in meningioma. PMID:33715086
Integrative analysis regarding the correlation between GAS2 family genes and human glioma prognosis. PMID:33713047
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. PMID:33712589
An epithelial-mesenchymal transition-related 5-gene signature predicting the prognosis of hepatocellular carcinoma patients. PMID:33712026
A comprehensive molecular characterization of the 8q22.2 region reveals the prognostic relevance of OSR2 mRNA in muscle invasive bladder cancer. PMID:33711044
Androgen receptor (AR) antagonism triggers acute succinate-mediated adaptive responses to reactivate AR signaling. PMID:33709547
Establishment of Novel DNA Methylation-Based Prostate Cancer Subtypes and a Risk-Predicting Eight-Gene Signature. PMID:33708770
High expression of aldolase A is associated with tumor progression and poor prognosis in hepatocellular carcinoma. PMID:33708434
Increased expression of MCM4 is associated with poor prognosis in patients with hepatocellular carcinoma. PMID:33708433
Identification of Core Genes Related to Progression and Prognosis of Hepatocellular Carcinoma and Small-Molecule Drug Predication. PMID:33708237
Identification of TRIM56 as a Potential Biomarker for Lung Adenocarcinoma. PMID:33707970
Differential alternative RNA splicing and transcription events between tumors from African American and White patients in The Cancer Genome Atlas. PMID:33705884
Significant non-existence of sequences in genomes and proteomes. PMID:33693858
NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer. PMID:33692855
Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response. PMID:33692370
GASC1 promotes hepatocellular carcinoma progression by inhibiting the degradation of ROCK2. PMID:33692332
Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair. PMID:33692124
In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer. PMID:33691672
Interferon regulatory factor 1(IRF-1) activates anti-tumor immunity via CXCL10/CXCR3 axis in hepatocellular carcinoma (HCC). PMID:33689775
FOXQ1 is Differentially Expressed Across Breast Cancer Subtypes with Low Expression Associated with Poor Overall Survival. PMID:33688250
Partial Response to Pyrotinib Plus Capecitabine in an Advanced Breast Cancer Patient with HER2 Amplification and R157W Mutation After Anti-HER2 Treatment: A Case Report and Literature Review. PMID:33688205
Expression and prognostic value of transcription-associated cyclin-dependent kinases in human breast cancer. PMID:33686962
Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors. PMID:33685991
Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with EGFR Exon 20 Insertions. PMID:33685865
Identification of tumor antigens and immune subtypes of cholangiocarcinoma for mRNA vaccine development. PMID:33685460
Deciphering the genetic alterations in matrix metallo-proteinase gene family and its putative association with head and neck squamous cell carcinoma. PMID:33681393
The Prognostic Value and Mechanisms of TMEM16A in Human Cancer. PMID:33681289
CD96 Correlates With Immune Infiltration and Impacts Patient Prognosis: A Pan-Cancer Analysis. PMID:33680972
KRAS mutation in pancreatic cancer. PMID:33676749
Molecular characterization of high-grade serous ovarian cancers occurring in younger and older women. PMID:33674143
Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer. PMID:33673346
Notch Signaling Pathway in Cancer-Review with Bioinformatic Analysis. PMID:33673145
Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer. PMID:33671201
Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics. PMID:33670680
Key Enzymes in Pyrimidine Synthesis, CAD and CPS1, Predict Prognosis in Hepatocellular Carcinoma. PMID:33670206
Downregulation of Cell Cycle and Checkpoint Genes by Class I HDAC Inhibitors Limits Synergism with G2/M Checkpoint Inhibitor MK-1775 in Bladder Cancer Cells. PMID:33670166
Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation. PMID:33669371
Multi-Omics Data Analysis of Gene Expressions and Alterations, Cancer-Associated Fibroblast and Immune Infiltrations, Reveals the Onco-Immune Prognostic Relevance of STAT3/CDK2/4/6 in Human Malignancies. PMID:33668805
Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer. PMID:33667385
Systemic Adaptive Immune Parameters Associated with Neuroblastoma Outcomes: the Significance of Gamma-Delta T Cells. PMID:33666857
E2F1: Cause and Consequence of DNA Replication Stress. PMID:33665206
Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients. PMID:33662628
MRPL13 Promotes Tumor Cell Proliferation, Migration and EMT Process in Breast Cancer Through the PI3K-AKT-mTOR Pathway. PMID:33658859
Integration of comprehensive genomic profiling, tumor mutational burden, and PD-L1 expression to identify novel biomarkers of immunotherapy in non-small cell lung cancer. PMID:33655698
MIG-6 is essential for promoting glucose metabolic reprogramming and tumor growth in triple-negative breast cancer. PMID:33655623
LRP1B mutations are associated with favorable outcomes to immune checkpoint inhibitors across multiple cancer types. PMID:33653800
Guanosine monophosphate synthase upregulation mediates cervical cancer progression by inhibiting the apoptosis of cervical cancer cells via the Stat3/P53 pathway. PMID:33649833
Identification of tumor antigens and immune subtypes of pancreatic adenocarcinoma for mRNA vaccine development. PMID:33648511
Protocol for proteogenomic dissection of intronic splicing enhancer interactome for prediction of individualized cancer prognosis. PMID:33644773
Enolase 1 Correlated With Cancer Progression and Immune-Infiltrating in Multiple Cancer Types: A Pan-Cancer Analysis. PMID:33643901
Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer. PMID:33643710
TMEM52B suppression promotes cancer cell survival and invasion through modulating E-cadherin stability and EGFR activity. PMID:33641663
Comprehensive Review of Molecular Mechanisms and Clinical Features of Invasive Lobular Cancer. PMID:33641217
Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas. PMID:33641091
Mutation-based clustering and classification analysis reveals distinctive age groups and age-related biomarkers for glioma. PMID:33639927
Transcriptional Biomarkers in Oral Cancer: An Integrative Analysis and the Cancer Genome Atlas Validation. PMID:33639650
Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors. PMID:33637626
Activated ALK Cooperates with N-Myc via Wnt/β-Catenin Signaling to Induce Neuroendocrine Prostate Cancer. PMID:33637566
Clinical benefit for clinical sequencing using cancer panel testing. PMID:33635883
Longitudinal CTCs gene expression analysis on metastatic castration-resistant prostate cancer patients treated with docetaxel reveals new potential prognosis markers. PMID:33635497
Low Expression of the Polycomb Protein RING1 Predicts Poor Prognosis in Human Breast Cancer. PMID:33634028
The Role of Interleukin-33 in Head and Neck Squamous Cell Carcinoma Is Determined by Its Cellular Sources in the Tumor Microenvironment. PMID:33634017
Identification and Validation of Efficacy of Immunological Therapy for Lung Cancer From Histopathological Images Based on Deep Learning. PMID:33633793
CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer. PMID:33633150
Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection. PMID:33632928
Susceptibility-Associated Genetic Variation in NEDD9 Contributes to Prostate Cancer Initiation and Progression. PMID:33632899
Comprehensive molecular profiling of Taiwanese breast cancers revealed potential therapeutic targets: prevalence of actionable mutations among 380 targeted sequencing analyses. PMID:33632156
Sparse data embedding and prediction by tropical matrix factorization. PMID:33632116
Potential Mechanism of Immune Evasion Associated with the Master Regulator ASCL2 in Microsatellite Stability in Colorectal Cancer. PMID:33628843
Reduced anoctamin 7 (ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer. PMID:33628598
How to Use Online Tools to Generate New Hypotheses for Mammary Gland Biology Research: A Case Study for Wnt7b. PMID:33625717
Exonuclease 1 (EXO1) is a Potential Prognostic Biomarker and Correlates with Immune Infiltrates in Lung Adenocarcinoma. PMID:33623391
Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes. PMID:33622998
High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability. PMID:33622270
Long non-coding RNA-based signature for predicting prognosis of hepatocellular carcinoma. PMID:33622186
Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A. PMID:33621062
YY1 regulated transcription-based stratification of gastric tumors and identification of potential therapeutic candidates. PMID:33620645
Immune classification of clear cell renal cell carcinoma. PMID:33619294
Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1. PMID:33619228
Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. PMID:33618763
Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Somatic Mutations in CDH1 and Other Clinically Actionable Mutations Imply Early Use of Targeted Agents. PMID:33617508
A Risk Prediction Model for Breast Cancer Based on Immune Genes Related to Early Growth Response Proteins Family. PMID:33614706
Down-Regulation of CIDEA Promoted Tumor Growth and Contributed to Cisplatin Resistance by Regulating the JNK-p21/Bad Signaling Pathways in Esophageal Squamous Cell Carcinoma. PMID:33614508
Autophagy Gene Panel-Based Prognostic Model in Myelodysplastic Syndrome. PMID:33614490
A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells. PMID:33613845
High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma. PMID:33613843
Transcription factor E2F4 is an indicator of poor prognosis and is related to immune infiltration in hepatocellular carcinoma. PMID:33613768
Stratification of Estrogen Receptor-Negative Breast Cancer Patients by Integrating the Somatic Mutations and Transcriptomic Data. PMID:33613637
ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition. PMID:33613118
Functional Prediction of Long Noncoding RNAs in Cutaneous Melanoma Using a Systems Biology Approach. PMID:33613027
Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data. PMID:33606788
Comprehensive Analysis of Prognostic and Immune Infiltrates for E2F Transcription Factors in Human Pancreatic Adenocarcinoma. PMID:33604289
Identification of potential therapeutic target of naringenin in breast cancer stem cells inhibition by bioinformatics and in vitro studies. PMID:33603536
Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression. PMID:33603163
Tumour gene expression signature in primary melanoma predicts long-term outcomes. PMID:33602918
Spatial Analysis and Clinical Significance of HLA Class-I and Class-II Subunit Expression in Non-Small Cell Lung Cancer. PMID:33602682
A distinct repertoire of cancer-associated fibroblasts is enriched in cribriform prostate cancer. PMID:33600062
Exploring the Differential Expression and Prognostic Significance of the COL11A1 Gene in Human Colorectal Carcinoma: An Integrated Bioinformatics Approach. PMID:33597969
Double inhibition and activation mechanisms of Ephexin family RhoGEFs. PMID:33597305
Identification of lipidomic profiles associated with drug-resistant prostate cancer cells. PMID:33596934
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity. PMID:33594203
Comprehensive analysis of macrophage-related multigene signature in the tumor microenvironment of head and neck squamous cancer. PMID:33592580
USP13 regulates the replication stress response by deubiquitinating TopBP1. PMID:33592542
Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. PMID:33591981
Clinical significance of STEAP1 extracellular vesicles in prostate cancer. PMID:33589770
Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. PMID:33588911
Evaluation of the susceptibility and fatality of lung cancer patients towards the COVID-19 infection: A systemic approach through analyzing the ACE2, CXCL10 and their co-expressed genes. PMID:33585826
Construction of Bone Metastasis-Specific Regulation Network Based on Prognostic Stemness-Related Signatures in Breast Invasive Carcinoma. PMID:33585235
Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer. PMID:33585209
The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype. PMID:33585078
Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions. PMID:33581682
Toll-Like Receptor 7 Mediates Inflammation Resolution and Inhibition of Angiogenesis in Non-Small Cell Lung Cancer. PMID:33578955
Differential Expression of a Panel of Ten CNTN1-Associated Genes during Prostate Cancer Progression and the Predictive Properties of the Panel Towards Prostate Cancer Relapse. PMID:33578925
Integrative Genomic Analyses of Patient-Matched Intracranial and Extracranial Metastases Reveal a Novel Brain-Specific Landscape of Genetic Variants in Driver Genes of Malignant Melanoma. PMID:33578810
Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma. PMID:33575479
CLIP4 Shows Putative Tumor Suppressor Characteristics in Breast Cancer: An Integrated Analysis. PMID:33575272
YEATS4 is associated with poor prognosis and promotes epithelial-to-mesenchymal transition and metastasis by regulating ZEB1 expression in breast cancer. PMID:33575079
Increased Expression of DNA2 Was Linked to Poor Prognosis in Breast Cancer. PMID:33574966
Targeted exome sequencing for the identification of common mutational signatures and potential driver mutations for brain metastases and prognosis. PMID:33574918
CC Chemokine Receptors in Lung Adenocarcinoma: The Inflammation-Related Prognostic Biomarkers and Immunotherapeutic Targets. PMID:33574689
Hematologic indices in individuals with pathogenic germline DICER1 variants. PMID:33570641
Solid tumours hijack the histone variant network. PMID:33568791
ZRSR2 overexpression is a frequent and early event in castration-resistant prostate cancer development. PMID:33568749
Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes. PMID:33568675
Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis. PMID:33568630
Integrated bioinformatic analysis identifies COL4A3, COL4A4, and KCNJ1 as key biomarkers in Wilms tumor. PMID:33564352
Inhibition of relaxin autocrine signaling confers therapeutic vulnerability in ovarian cancer. PMID:33561012
Identification of an immune-related risk signature and nomogram predicting the overall survival in patients with endometrial cancer. PMID:33559412
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide. PMID:33558541
Pan-Cancer Analysis Shows TP53 Mutations Modulate the Association of NOX4 with Genetic Programs of Cancer Progression and Clinical Outcome. PMID:33557266
Targeting the Hippo Pathway in Prostate Cancer: What's New? PMID:33557087
Personalized oncology and BRAFK601N melanoma: model development, drug discovery, and clinical correlation. PMID:33555379
Toll-like receptor 4 signaling activates ERG function in prostate cancer and provides a therapeutic target. PMID:33554122
Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer. PMID:33553736
Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer. PMID:33553693
Profiles of alternative splicing landscape in breast cancer and their clinical significance: an integrative analysis based on large-sequencing data. PMID:33553351
Genetic Architectures and Cell-of-Origin in Glioblastoma. PMID:33552990
Prognostic Implications of Pan-Cancer CMTM6 Expression and Its Relationship with the Immune Microenvironment. PMID:33552963
Suppression of p16 alleviates the senescence-associated secretory phenotype. PMID:33550279
Crystal structure of the human PRPK-TPRKB complex. PMID:33547416
NLRC5/CITA expression correlates with efficient response to checkpoint blockade immunotherapy. PMID:33547395
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma. PMID:33547292
Prostate cancer. PMID:33542230
High ROBO3 expression predicts poor survival in non-M3 acute myeloid leukemia. PMID:33541130
Evolutionary Conservation of Structural and Functional Coupling between the BRM AT-Hook and Bromodomain. PMID:33539881
Elevated NSD3 histone methylation activity drives squamous cell lung cancer. PMID:33536620
A short deletion in the DNA-binding domain of STAT3 suppresses growth and progression of colon cancer cells. PMID:33535185
Survival outcomes are associated with genomic instability in luminal breast cancers. PMID:33534788
Glycolytic expression in lower-grade glioma reveals an epigenetic association between IDH mutation status and PDL1/2 expression. PMID:33532725
Carbon ion triggered immunogenic necroptosis of nasopharyngeal carcinoma cells involving necroptotic inhibitor BCL-x. PMID:33531997
Construction of a Glycolysis-related long noncoding RNA signature for predicting survival in endometrial cancer. PMID:33531988
Identification of novel biomarkers and candidate small-molecule drugs in cutaneous melanoma by comprehensive gene microarrays analysis. PMID:33531976
Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling. PMID:33531625
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer. PMID:33531470
Preclinical Evaluation of B7-H3-specific Chimeric Antigen Receptor T Cells for the Treatment of Acute Myeloid Leukemia. PMID:33531429
Hierarchical tumor heterogeneity mediated by cell contact between distinct genetic subclones. PMID:33529175
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. PMID:33529165
Brahma-Related Gene-1 (BRG1) promotes the malignant phenotype of glioblastoma cells. PMID:33528916
Transcriptional E2F1/2/3/6 as potential prognostic biomarkers in cutaneous melanoma. PMID:33527034
CARD11 alteration as a candidate biomarker of skin cutaneous melanoma treated with immune checkpoint blockade. PMID:33527024
Proteasomal Regulation of Mammalian SPT16 in Controlling Transcription. PMID:33526453
Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling. PMID:33526450
Reuse of Molecules for Glioblastoma Therapy. PMID:33525329
NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription. PMID:33520407
Epigenetically silenced linc00261 contributes to the metastasis of hepatocellular carcinoma via inducing the deficiency of FOXA2 transcription. PMID:33520374
Generating Ensembles of Gene Regulatory Networks to Assess Robustness of Disease Modules. PMID:33519907
Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding. PMID:33515600
The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo. PMID:33514834
My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype. PMID:33514395
Restoring the DREAM Complex Inhibits the Proliferation of High-Risk HPV Positive Human Cells. PMID:33513914
Integrin α3β1 Promotes Invasive and Metastatic Properties of Breast Cancer Cells through Induction of the Brn-2 Transcription Factor. PMID:33513758
Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors. PMID:33513287
ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models. PMID:33512452
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer. PMID:33509944
Therapeutic Implications of Detecting MAPK-Activating Alterations in Cutaneous and Unknown Primary Melanomas. PMID:33509808
Molecular and immune signature of HPV-positive oral cavity squamous cell carcinoma. PMID:33509683
OIP5-AS1 specifies p53-driven POX transcription regulated by TRPC6 in glioma. PMID:33508123
Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases. PMID:33507258
Dissecting the Invasion-Associated Long Non-coding RNAs Using Single-Cell RNA-Seq Data of Glioblastoma. PMID:33505440
Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression. PMID:33504618
Cancer of Unknown Primary: Challenges and Progress in Clinical Management. PMID:33504059
K3326X and Other C-Terminal BRCA2 Variants Implicated in Hereditary Cancer Syndromes: A Review. PMID:33503928
Development of a prognostic index based on immunogenomic landscape analysis in glioma. PMID:33503296
PHLPPing the balance: restoration of protein kinase C in cancer. PMID:33502516
High LARGE1 Expression May Predict Benefit from Adjuvant Chemotherapy in Resected Non-Small-Cell Lung Cancer. PMID:33500650
Effective Prediction of Prostate Cancer Recurrence through the IQGAP1 Network. PMID:33498739
Nexus between PI3K/AKT and Estrogen Receptor Signaling in Breast Cancer. PMID:33498407
RSF1 requires CEBP/β and hSNF2H to promote IL-1β-mediated angiogenesis: the clinical and therapeutic relevance of RSF1 overexpression and amplification in myxofibrosarcomas. PMID:33496909
An improved assay for detection of theranostic gene translocations and MET exon 14 skipping in thoracic oncology. PMID:33495574
TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin. PMID:33495197
Immune Resistance in Lung Adenocarcinoma. PMID:33494181
IPPC: an interactive platform for prostate cancer multi-omics data integration and analysis. PMID:33493265
Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers. PMID:33493140
Expression and prognostic analyses of SCAMPs in pancreatic adenocarcinoma. PMID:33493138
Genomic alterations predictive of response to radiosurgery in recurrent IDH-WT glioblastoma. PMID:33492602
COL1A1 Is a Potential Prognostic Biomarker and Correlated with Immune Infiltration in Mesothelioma. PMID:33490271
Analysis of the Prognosis and Therapeutic Value of the CXC Chemokine Family in Head and Neck Squamous Cell Carcinoma. PMID:33489879
BRAF AMP Frequently Co-occurs With IDH1/2, TP53, and ATRX Mutations in Adult Patients With Gliomas and Is Associated With Poorer Survival Than That of Patients Harboring BRAF V600E. PMID:33489866
KYNU, a novel potential target that underpins CD44-promoted breast tumour cell invasion. PMID:33486887
Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia. PMID:33485366
The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer. PMID:33483585
Online informatics resources to facilitate cancer target and chemical probe discovery. PMID:33479663
L-Selectin expression is associated with inflammatory microenvironment and favourable prognosis in breast cancer. PMID:33479593
Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells. PMID:33475085
Liquid biopsy enters the clinic - implementation issues and future challenges. PMID:33473219
CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer. PMID:33471959
Identification of Prognostic Biomarkers and Molecular Targets Among JAK Family in Breast Cancer. PMID:33469338
Tumor infiltrating lymphocyte clusters are associated with response to immune checkpoint inhibition in BRAF V600E/K mutated malignant melanomas. PMID:33469107
Triple-Negative Breast Cancer and the COVID-19 Pandemic: Clinical Management Perspectives and Potential Consequences of Infection. PMID:33467411
The Taming of Nuclear Factor Erythroid-2-Related Factor-2 (Nrf2) Deglycation by Fructosamine-3-Kinase (FN3K)-Inhibitors-A Novel Strategy to Combat Cancers. PMID:33466626
Mechanisms of Resistance to KRASG12C Inhibitors. PMID:33466360
Molecular Changes in Retinoblastoma beyond RB1: Findings from Next-Generation Sequencing. PMID:33466343
A novel immunogenomic prognostic signature in lung squamous carcinoma. PMID:33466167
Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma. PMID:33461580
CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer. PMID:33461170
Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer. PMID:33457104
MRPL27 contributes to unfavorable overall survival and disease-free survival from cholangiocarcinoma patients. PMID:33456351
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair. PMID:33452241
Secretoglobin 3A2 eliminates human cancer cells through pyroptosis. PMID:33452234
AhR and Cancer: From Gene Profiling to Targeted Therapy. PMID:33451095
Correlation of genomic alterations and PD-L1 expression in thymoma. PMID:33447447
Genomic alterations in thymoma-molecular pathogenesis? PMID:33447444
CD117/c-kit defines a prostate CSC-like subpopulation driving progression and TKI resistance. PMID:33446896
Roles of the BAP1 Tumor Suppressor in Cell Metabolism. PMID:33446574
Characterization of SOX2, OCT4 and NANOG in Ovarian Cancer Tumor-Initiating Cells. PMID:33445692
Combined assay of Circulating Tumor DNA and Protein Biomarkers for early noninvasive detection and prognosis of Non-Small Cell Lung Cancer. PMID:33442424
Transcript levels of keratin 1/5/6/14/15/16/17 as potential prognostic indicators in melanoma patients. PMID:33441834
Lipid droplet biogenesis and COX-2 pathway activation are triggered by Barrett's esophagus and adenocarcinoma, but not esophageal squamous cell carcinoma risk factors. PMID:33441691
Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy. PMID:33441554
Integrate analysis of the promote function of Cell division cycle-associated protein family to pancreatic adenocarcinoma. PMID:33437202
A modular master regulator landscape controls cancer transcriptional identity. PMID:33434495
Cell-Intrinsic Tumorigenic Functions of PPARγ in Bladder Urothelial Carcinoma. PMID:33431608
XXYLT1 methylation contributes to the occurrence of lung adenocarcinoma: Methylation and lung adenocarcinoma. PMID:33429795
Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2). PMID:33428613
Relevance of STK11 Mutations Regarding Immune Cell Infiltration, Drug Sensitivity, and Cellular Processes in Lung Adenocarcinoma. PMID:33425731
Downregulation of Brain Enriched Type 2 MAGEs Is Associated With Immune Infiltration and Poor Prognosis in Glioma. PMID:33425727
PD-L1 and PD-L2 Expression in Cervical Cancer: Regulation and Biomarker Potential. PMID:33424844
A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance. PMID:33420373
Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype. PMID:33420368
EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma. PMID:33420027
Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy. PMID:33417860
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. PMID:33417831
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma. PMID:33414994
Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth. PMID:33414169
Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway. PMID:33412308
Integrated bioinformatic analysis of RNA binding proteins in hepatocellular carcinoma. PMID:33411682
Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation. PMID:33408774
Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer. PMID:33407715
Development of nomogram based on immune-related gene FGFR4 for advanced non-small cell lung cancer patients with sensitivity to immune checkpoint inhibitors. PMID:33407583
Construction of a nine DNA repair-related gene prognostic classifier to predict prognosis in patients with endometrial carcinoma. PMID:33407221
Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein. PMID:33405952
Prognostic implication of glycolysis related gene signature in non-small cell lung cancer. PMID:33403045
Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway. PMID:33403043
BRCA1/2 pathogenic variants in triple-negative versus luminal-like breast cancers: genotype-phenotype correlation in a cohort of 531 patients. PMID:33403015
Identification of a novel six autophagy-related genes signature for the prognostic and a miRNA-related autophagy predictor for anti-PD-1 therapy responses in prostate cancer. PMID:33402116
Pseudogene Annexin A2 Pseudogene 1 Contributes to Hepatocellular Carcinoma Progression by Modulating Its Parental Gene ANXA2 via miRNA-376a-3p. PMID:33398718
Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies. PMID:33398072
Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer. PMID:33397968
Targeting Lymphotoxin Beta and Paired Box 5: a potential therapeutic strategy for soft tissue sarcoma metastasis. PMID:33397394
The ITIM-Containing Receptor: Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) Modulates Immune Response and Confers Poor Prognosis in Invasive Breast Carcinoma. PMID:33396670
The Impact of Immunofunctional Phenotyping on the Malfunction of the Cancer Immunity Cycle in Breast Cancer. PMID:33396390
Cyclin-dependent Kinase 1 and Aurora Kinase choreograph mitotic storage and redistribution of a growth factor receptor. PMID:33395410
Interplay Between EGFR and the Platelet-Activating Factor/PAF Receptor Signaling Axis Mediates Aggressive Behavior of Cervical Cancer. PMID:33392068
Using The Cancer Genome Atlas as an Inquiry Tool in the Undergraduate Classroom. PMID:33391340
Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma. PMID:33390805
Discovery of acquired molecular signature on immune checkpoint inhibitors in paired tumor tissues. PMID:33389015
SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma. PMID:33387348
Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency. PMID:33385162
Functional Gene Expression Differentiation of the Notch Signaling Pathway in Female Reproductive Tract Tissues-A Comprehensive Review With Analysis. PMID:33384996
HOXA5 Expression Is Elevated in Breast Cancer and Is Transcriptionally Regulated by Estradiol. PMID:33384715
Genomic and transcriptomic landscape of conjunctival melanoma. PMID:33383577
Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer. PMID:33383310
HeartBioPortal2.0: new developments and updates for genetic ancestry and cardiometabolic quantitative traits in diverse human populations. PMID:33382884
Targeting BRD9 for Cancer Treatment: A New Strategy. PMID:33380808
USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells. PMID:33378683
Hypoxic exposure activates the B cell-specific Moloney murine leukaemia virus integration site 1/PI3K/Akt axis and promotes EMT in leukaemia stem cells. PMID:33376531
Effect of let-7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma. PMID:33376529
Characterizing TP53 mutations in ovarian carcinomas with and without concurrent BRCA1 or BRCA2 mutations. PMID:33375991
AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer? PMID:33375416
High Risk α-HPV E6 Impairs Translesion Synthesis by Blocking POLη Induction. PMID:33374731
Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma. PMID:33369458
Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes-Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans. PMID:33368437
Transcription factor networks of oligodendrogliomas treated with adjuvant radiotherapy or observation inform prognosis. PMID:33367753
m5C RNA Methylation Primarily Affects the ErbB and PI3K-Akt Signaling Pathways in Gastrointestinal Cancer. PMID:33365328
Overexpression of rhophilin 2 promotes pancreatic ductal adenocarcinoma. PMID:33365087
Systematic Analysis of Expression Profiles and Prognostic Significance for FAM83 Family in Non-small-Cell Lung Cancer. PMID:33363204
Beyond TNBC: Repositioning of Clofazimine Against a Broad Range of Wnt-Dependent Cancers. PMID:33363033
AUNIP Expression Is Correlated With Immune Infiltration and Is a Candidate Diagnostic and Prognostic Biomarker for Hepatocellular Carcinoma and Lung Adenocarcinoma. PMID:33363020
Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer. PMID:33363011
Alterations in TP53 Are a Potential Biomarker of Bladder Cancer Patients Who Benefit From Immune Checkpoint Inhibition. PMID:33356494
Molecular Network Profiling in Intestinal- and Diffuse-Type Gastric Cancer. PMID:33353109
AKR1C3 Is Associated with Better Survival of Patients with Endometrial Carcinomas. PMID:33352741
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification. PMID:33350495
Cytoskeletal Control and Wnt Signaling-APC's Dual Contributions in Stem Cell Division and Colorectal Cancer. PMID:33348689
Bioinformatics analysis identifies COL1A1, THBS2 and SPP1 as potential predictors of patient prognosis and immunotherapy response in gastric cancer. PMID:33345281
Identification of the Roles of Chromobox Family Members in Gastric Cancer: A Study Based on Multiple Datasets. PMID:33344640
Hypoxia-Associated Prognostic Markers and Competing Endogenous RNA Co-Expression Networks in Breast Cancer. PMID:33344235
Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer. PMID:33342055
Key pathways in prostate cancer with SPOP mutation identified by bioinformatic analysis. PMID:33336059
Attenuation of SRC Kinase Activity Augments PARP Inhibitor-mediated Synthetic Lethality in BRCA2-altered Prostate Tumors. PMID:33334906
A Critical Role for Fas-Mediated Off-Target Tumor Killing in T-cell Immunotherapy. PMID:33334730
The PARP Inhibitor Olaparib Modulates the Transcriptional Regulatory Networks of Long Non-Coding RNAs during Vasculogenic Mimicry. PMID:33333852
Prognostic Biomarker TP53 Mutations for Immune Checkpoint Blockade Therapy and Its Association With Tumor Microenvironment of Lung Adenocarcinoma. PMID:33330629
Increased NFATC4 Correlates With Poor Prognosis of AML Through Recruiting Regulatory T Cells. PMID:33329712
Drug Response Associated With and Prognostic lncRNAs Mediated by DNA Methylation and Transcription Factors in Colon Cancer. PMID:33329694
Identification of Mutated Peptides in Bladder Cancer From Exomic Sequencing Data Reveals Negative Correlation Between Mutation-Specific Immunoreactivity and Inflammation. PMID:33329543
Identification of Interleukin-9 Producing Immune Cells in Endometrial Carcinoma and Establishment of a Prognostic Nomogram. PMID:33329510
Oncology and Pharmacogenomics Insights in Polycystic Ovary Syndrome: An Integrative Analysis. PMID:33329391
FIREWORKS: a bottom-up approach to integrative coessentiality network analysis. PMID:33328249
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. PMID:33326793
Identification of Metabolism-Associated Prostate Cancer Subtypes and Construction of a Prognostic Risk Model. PMID:33324566
Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II-practical challenges. PMID:33323463
Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer. PMID:33322840
CDKN2A-Inactivated Pancreatic Ductal Adenocarcinoma Exhibits Therapeutic Sensitivity to Paclitaxel: A Bioinformatics Study. PMID:33322698
The Molecular 'Myc-anisms' Behind Myc-Driven Tumorigenesis and the Relevant Myc-Directed Therapeutics. PMID:33322239
Activation of the Ion Channel TRPV4 Induces Epithelial to Mesenchymal Transition in Breast Cancer Cells. PMID:33322037
Regulation of ST6GAL1 sialyltransferase expression in cancer cells. PMID:33320246
Prognostic value of intratumoral lymphocyte-to-monocyte ratio and M0 macrophage enrichment in tumor immune microenvironment of melanoma. PMID:33318782
Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity. PMID:33318037
Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres. PMID:33317554
Expression of PAWR predicts prognosis of ovarian cancer. PMID:33317551
Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells. PMID:33316932
A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death. PMID:33314700
Role of SPTSSB-Regulated de Novo Sphingolipid Synthesis in Prostate Cancer Depends on Androgen Receptor Signaling. PMID:33313495
CCTs as new biomarkers for the prognosis of head and neck squamous cancer. PMID:33313411
Genomic analysis of the prognostic effect of tumor-associated neutrophil-related genes across 15 solid cancer types: an immune perspective. PMID:33313252
Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma. PMID:33312955
Updates on "Cancer Genomics and Epigenomics". PMID:33312884
Circulating tumor DNA analysis of metastatic renal cell carcinoma. PMID:33312563
Targeted massively parallel sequencing of mature lymphoid neoplasms: assessment of empirical application and diagnostic utility in routine clinical practice. PMID:33311649
Intron retention is a robust marker of intertumoral heterogeneity in pancreatic ductal adenocarcinoma. PMID:33311498
Differential genetic mutations of ectoderm, mesoderm, and endoderm-derived tumors in TCGA database. PMID:33308219
A Gene Mutation Signature Predicting Immunotherapy Benefits in Patients With NSCLC. PMID:33307194
SPRED1 deletion confers resistance to MAPK inhibition in melanoma. PMID:33306107
Computational methods for detecting cancer hotspots. PMID:33304455
M1 Polarization Markers Are Upregulated in Basal-Like Breast Cancer Molecular Subtype and Associated With Favorable Patient Outcome. PMID:33304345
The conformational and mutational landscape of the ubiquitin-like marker for autophagosome formation in cancer. PMID:33302793
Angiogenesis-Related Gene Expression Signatures Predicting Prognosis in Gastric Cancer Patients. PMID:33302481
The role of the SWI/SNF chromatin remodeling complex in pancreatic ductal adenocarcinoma. PMID:33301642
A metastasis map of human cancer cell lines. PMID:33299191
Genomic investigation of co-targeting tumor immune microenvironment and immune checkpoints in pan-cancer immunotherapy. PMID:33299118
BMP signaling is a therapeutic target in ovarian cancer. PMID:33298901
The ZNF750-RAC1 axis as potential prognostic factor for breast cancer. PMID:33298895
Identification of Genes Required for Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells In Vitro. PMID:33298586
Human Papillomavirus 16 (HPV16) E2 Repression of TWIST1 Transcription Is a Potential Mediator of HPV16 Cancer Outcomes. PMID:33298572
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer. PMID:33298139
Multi-Omics Analysis Identifying Key Biomarkers in Ovarian Cancer. PMID:33297760
Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer. PMID:33294279
MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role. PMID:33293474
Recurrent SETD2 mutation in NPM1-mutated acute myeloid leukemia. PMID:33292784
Assessing immune infiltration and the tumor microenvironment for the diagnosis and prognosis of sarcoma. PMID:33292275
Evaluation of Clinicopathological and Molecular Parameters on Disease Recurrence of Papillary Thyroid Cancer Patient: A Retrospective Observational Study. PMID:33291668
Identification of "regulation of RhoA activity panel" as a prognostic and predictive biomarker for gastric cancer. PMID:33288739
The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma. PMID:33287763
Identification of a four-gene panel predicting overall survival for lung adenocarcinoma. PMID:33287749
Focus on DNA Glycosylases-A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets. PMID:33287345
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer. PMID:33282948
β-hydroxybutyrate does not alter the effects of glucose deprivation on breast cancer cells. PMID:33281976
PARPBP is a prognostic marker and confers anthracycline resistance to breast cancer. PMID:33281951
Immune-Related Gene-Based Novel Subtypes to Establish a Model Predicting the Risk of Prostate Cancer. PMID:33281882
SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence. PMID:33277667
An integrated approach to biomarker discovery reveals gene signatures highly predictive of cancer progression. PMID:33277589
NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis. PMID:33276631
Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration-resistant prostate cancer. PMID:33275817
A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3. PMID:33273692
Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma. PMID:33272983
Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas. PMID:33271120
Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors. PMID:33270827
G Protein-Coupled receptors and heterotrimeric G proteins as cancer drivers. PMID:33270228
The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer. PMID:33270085
Oncogenic Roles of RAD51AP1 in Tumor Tissues Related to Overall Survival and Disease-Free Survival in Hepatocellular Carcinoma. PMID:33269607
Multi-Omics Database Analysis of Aminoacyl-tRNA Synthetases in Cancer. PMID:33266490
Construction of a Novel Multigene Panel Potently Predicting Poor Prognosis in Patients with Clear Cell Renal Cell Carcinoma. PMID:33266355
Differential Effects of Cancer-Associated Mutations Enriched in Helix H3 of PPARγ. PMID:33266062
Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer. PMID:33264619
Exome sequencing identifies ARID2 as a novel tumor suppressor in early-onset sporadic rectal cancer. PMID:33262464
Functional characterization of uveal melanoma oncogenes. PMID:33262460
Degree of Early Estrogen Response Predict Survival after Endocrine Therapy in Primary and Metastatic ER-Positive Breast Cancer. PMID:33260779
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression. PMID:33257795
ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin's lymphoma and testicular cancer cells. PMID:33257682
Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups. PMID:33256706
Lectin-Like Transcript 1 (LLT1) Checkpoint: A Novel Independent Prognostic Factor in HPV-Negative Oropharyngeal Squamous Cell Carcinoma. PMID:33255617
TET2/IDH1/2/WT1 and NPM1 Mutations Influence the RUNX1 Expression Correlations in Acute Myeloid Leukemia. PMID:33255417
Effective RNA Knockdown Using CRISPR-Cas13a and Molecular Targeting of the EML4-ALK Transcript in H3122 Lung Cancer Cells. PMID:33255340
Targeted Sequencing of Pancreatic Adenocarcinomas from Patients with Metachronous Pulmonary Metastases. PMID:33255265
Identification of potential biomarkers for lung adenocarcinoma. PMID:33251353
VarStack: a web tool for data retrieval to interpret somatic variants in cancer. PMID:33247936
Overexpression of BASP1 Indicates a Poor Prognosis in Head and Neck Squamous Cell Carcinoma. PMID:33247706
c-KIT-ERK1/2 signaling activated ELK1 and upregulated carcinoembryonic antigen expression to promote colorectal cancer progression. PMID:33247506
Premature termination codons in SOD1 causing Amyotrophic Lateral Sclerosis are predicted to escape the nonsense-mediated mRNA decay. PMID:33244158
Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics. PMID:33244070
Lower mutant-allele tumor heterogeneity is a biomarker in FGFR3-mutant bladder cancer for better prognosis. PMID:33243261
The discovery of AVIL as a bona fide oncogene in glioblastoma. PMID:33241106
CDK5 Inhibition Abrogates TNBC Stem-Cell Property and Enhances Anti-PD-1 Therapy. PMID:33240752
Improving existing analysis pipeline to identify and analyze cancer driver genes using multi-omics data. PMID:33239644
Prognostic Value of Gastrokine-2 (GKN2) and Its Correlation with Tumor-Infiltrating Immune Cells in Lung Cancer and Gastric Cancers. PMID:33235482
Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells. PMID:33232921
Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis. PMID:33232824
Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. PMID:33232662
Discovering novel driver mutations from pan-cancer analysis of mutational and gene expression profiles. PMID:33232371
Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer. PMID:33231569
Pan-cancer methylation analysis reveals an inverse correlation of tumor immunogenicity with methylation aberrancy. PMID:33230567
Identification of transcription factor co-regulators that drive prostate cancer progression. PMID:33230156
SWI/SNF Alterations in Squamous Bladder Cancers. PMID:33227989
Clinicopathological and immunological characterization of RNA m6 A methylation regulators in ovarian cancer. PMID:33225598
A Clinical Genomics-Guided Prioritizing Strategy Enables Selecting Proper Cancer Cell Lines for Biomedical Research. PMID:33225250
Cell Plasticity-Related Phenotypes and Taxanes Resistance in Castration-Resistant Prostate Cancer. PMID:33224888
In Search of TGCT Biomarkers: A Comprehensive In Silico and Histopathological Analysis. PMID:33224314
Clinical and molecular distinctions in patients with refractory colon cancer who benefit from regorafenib treatment. PMID:33224274
FGFR3 Alterations in the Era of Immunotherapy for Urothelial Bladder Cancer. PMID:33224141
Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma. PMID:33223751
A novel miRNA inhibits metastasis of prostate cancer via decreasing CREBBP-mediated histone acetylation. PMID:33221996
CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer. PMID:33218188
Genetic Mutations and Variants in the Susceptibility of Familial Non-Medullary Thyroid Cancer. PMID:33218058
Genomic Amplification and Functional Dependency of the Gamma Actin Gene ACTG1 in Uterine Cancer. PMID:33217970
MEK is a promising target in the basal subtype of bladder cancer. PMID:33216841
Frequency and prognostic value of mutations associated with the homologous recombination DNA repair pathway in a large pan cancer cohort. PMID:33214570
Integrated Multi-Tumor Radio-Genomic Marker of Outcomes in Patients with High Serous Ovarian Carcinoma. PMID:33212885
Functional role of vitronectin in breast cancer. PMID:33211735
Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA. PMID:33210317
Angiogenesis related gene expression significantly associated with the prognostic role of an urothelial bladder carcinoma. PMID:33209684
Upregulation of ERCC6L is associated with tumor progression and unfavorable prognosis in hepatocellular carcinoma. PMID:33209494
Expression and prognostic value of Chromobox family members in gastric cancer. PMID:33209492
Comprehensive analysis of the prognosis for chromobox family in gastric cancer. PMID:33209489
The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer. PMID:33205077
Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality. PMID:33205017
A prognostic risk model based on immune-related genes predicts overall survival of patients with hepatocellular carcinoma. PMID:33204848
Somatic mutational landscapes of adherens junctions and their functional consequences in cutaneous melanoma development. PMID:33204327
TP53 mutations and CDKN2A mutations/deletions are highly recurrent molecular alterations in the malignant progression of sinonasal papillomas. PMID:33203919
ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL. PMID:33203881
Cancer Stem Cells and the Slow Cycling Phenotype: How to Cut the Gordian Knot Driving Resistance to Therapy in Melanoma. PMID:33202944
USP25 Regulates EGFR Fate by Modulating EGF-Induced Ubiquitylation Dynamics. PMID:33202887
Biomarker Development for Metastatic Renal Cell Carcinoma: Omics, Antigens, T-cells, and Beyond. PMID:33202724
Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer. PMID:33199492
EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers. PMID:33199443
E3 Ubiquitin Ligase TRIP12: Regulation, Structure, and Physiopathological Functions. PMID:33198194
Plasmacytoid Dendritic Cell (pDC) Infiltration Correlate with Tumor Infiltrating Lymphocytes, Cancer Immunity, and Better Survival in Triple Negative Breast Cancer (TNBC) More Strongly than Conventional Dendritic Cell (cDC). PMID:33198125
Mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon: detailed molecular characterisation of two cases indicates a distinct colorectal cancer entity. PMID:33197299
CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics. PMID:33196823
PAXX, Not NHEJ1 Is an Independent Prognosticator in Colon Cancer. PMID:33195430
The Landscape of Coronavirus Disease 2019 (COVID-19) and Integrated Analysis SARS-CoV-2 Receptors and Potential Inhibitors in Lung Adenocarcinoma Patients. PMID:33195212
Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter? PMID:33194757
Molecular and Clinical Characterization of a Novel Prognostic and Immunologic Biomarker FAM111A in Diffuse Lower-Grade Glioma. PMID:33194678
The Resistance Mechanisms of Lung Cancer Immunotherapy. PMID:33194652
Development and validation of a survival model based on autophagy-associated genes for predicting prognosis of hepatocellular carcinoma. PMID:33194067
Integration of Online Omics-Data Resources for Cancer Research. PMID:33193699
Multi-Omics Analysis Detects Novel Prognostic Subgroups of Breast Cancer. PMID:33193681
Theoretical and in silico Analyses Reveal MYC as a Dynamic Network Biomarker in Colon and Rectal Cancer. PMID:33193630
Data mining combined with experiments to validate CEP55 as a prognostic biomarker in colorectal cancer. PMID:33190424
Prognostic roles of metabolic reprogramming-associated genes in patients with hepatocellular carcinoma. PMID:33188160
SLX4IP Promotes Telomere Maintenance in Androgen Receptor-Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization. PMID:33188147
A Targeted Bioinformatics Assessment of Adrenocortical Carcinoma Reveals Prognostic Implications of GABA System Gene Expression. PMID:33187258
Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq. PMID:33184288
Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival. PMID:33182511
Spectrum of Mesenchymal-Epithelial Transition Aberrations and Potential Clinical Implications: Insights From Integrative Pancancer Analysis. PMID:33178590
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer. PMID:33177715
PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways. PMID:33177155
5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts. PMID:33176741
HNF1B inhibits cell proliferation via repression of SMAD6 expression in prostate cancer. PMID:33174391
Combination of lysine-specific demethylase 6A (KDM6A) and mismatch repair (MMR) status is a potential prognostic factor in colorectal cancer. PMID:33174323
Integrative Analysis of HNF1B mRNA in Human Cancers Based on Data Mining. PMID:33173410
Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing. PMID:33173047
Cold-inducible RNA binding protein promotes breast cancer cell malignancy by regulating Cystatin C levels. PMID:33172965
Clinical and mutational profiles of adult medulloblastoma groups. PMID:33172502
Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis. PMID:33172155
Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells. PMID:33171110
Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions. PMID:33168106
EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer. PMID:33167919
Potential roles of PBRM1 on immune infiltration in cholangiocarcinoma. PMID:33165423
Isocitrate dehydrogenase 3A, a rate-limiting enzyme of the TCA cycle, promotes hepatocellular carcinoma migration and invasion through regulation of MTA1, a core component of the NuRD complex. PMID:33163266
Roles for the FCRL6 Immunoreceptor in Tumor Immunology. PMID:33162991
HCK can serve as novel prognostic biomarker and therapeutic target for Breast Cancer patients. PMID:33162805
Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA. PMID:33161228
Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome. PMID:33158447
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. PMID:33157015
Early Gastric Cancer: identification of molecular markers able to distinguish submucosa-penetrating lesions with different prognosis. PMID:33156452
Overexpression of Rhophilin Rho GTPase-binding protein 2 promotes hepatocellular carcinoma. PMID:33154780
Characterization of Mutational Status, Spheroid Formation, and Drug Response of a New Genomically-Stable Human Ovarian Clear Cell Carcinoma Cell Line, 105C. PMID:33153119
Differential Expression of PEG10 Contributes to Aggressive Disease in Early Versus Late-Onset Colorectal Cancer. PMID:33149023
Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells. PMID:33148662
Neuroendocrine tumours of the breast: a genomic comparison with mucinous breast cancers and neuroendocrine tumours of other anatomic sites. PMID:33148628
Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations. PMID:33147938
Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment. PMID:33146700
Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion. PMID:33144694
Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients. PMID:33144586
"Serine and One-Carbon Metabolism in Breast Cancer Metastasis"-Letter. PMID:33144383
GBAF, a small BAF sub-complex with big implications: a systematic review. PMID:33143733
Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer. PMID:33142117
Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47phox. PMID:33139577
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status. PMID:33138032
Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation. PMID:33137094
netboxr: Automated discovery of biological process modules by network analysis in R. PMID:33137091
Characterization of the Tumor Immune Microenvironment Identifies M0 Macrophage-Enriched Cluster as a Poor Prognostic Factor in Hepatocellular Carcinoma. PMID:33136432
TERT promoter mutation associated with multifocal phenotype and poor prognosis in patients with IDH wild-type glioblastoma. PMID:33134923
Crosstalk Between MYC and lncRNAs in Hematological Malignancies. PMID:33134177
Chaperones and Ubiquitin Ligases Balance Mutant p53 Protein Stability in Esophageal and Other Digestive Cancers. PMID:33130332
TIM3 expression on tumor cells predicts response to anti-PD-1 therapy for renal cancer. PMID:33129110
Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression. PMID:33127842
Trametinib Induces the Stabilization of a Dual GNAQ p.Gly48Leu- and FGFR4 p.Cys172Gly-Mutated Uveal Melanoma. The Role of Molecular Modelling in Personalized Oncology. PMID:33126538
YAP/TAZ Signalling in Colorectal Cancer: Lessons from Consensus Molecular Subtypes. PMID:33126419
Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state. PMID:33125139
Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia. PMID:33123685
ATP6AP2 is Overexpressed in Breast Cancer and Promotes Breast Cancer Progression. PMID:33122944
Screening and identification of key genes and pathways in metastatic uveal melanoma based on gene expression using bioinformatic analysis. PMID:33120861
Multiomic Integration of Public Oncology Databases in Bioconductor. PMID:33119407
Comprehensive Analysis of Prognostic Markers for Acute Myeloid Leukemia Based on Four Metabolic Genes. PMID:33117716
TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L. PMID:33115448
Non-Canonical Functions of the Gamma-Tubulin Meshwork in the Regulation of the Nuclear Architecture. PMID:33114224
USP1 Regulates TAZ Protein Stability Through Ubiquitin Modifications in Breast Cancer. PMID:33114077
Comprehensive analysis of the expression of SLC30A family genes and prognosis in human gastric cancer. PMID:33110097
Naturally occurring hotspot cancer mutations in Gα13 promote oncogenic signaling. PMID:33109615
WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer. PMID:33109540
Functional and genomic characterization of patient-derived xenograft model to study the adaptation to mTORC1 inhibitor in clear cell renal cell carcinoma. PMID:33107222
RNA-binding protein DDX3 mediates posttranscriptional regulation of androgen receptor: A mechanism of castration resistance. PMID:33106406
Prognostic Significance of Oxidation Pathway Mutations in Recurrent Laryngeal Squamous Cell Carcinoma. PMID:33105726
MN1 overexpression with varying tumor grade is a promising predictor of survival of glioma patients. PMID:33105486
Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis. PMID:33102693
DEC2 Serves as Potential Tumor Suppressor in Breast Carcinoma. PMID:33101542
Small interfering RNA-mediated knockdown of KRT80 suppresses colorectal cancer proliferation. PMID:33101466
Development and Validation of an Immune-Related lncRNA Signature for Predicting the Prognosis of Hepatocellular Carcinoma. PMID:33101369
Emerging epigenetic therapeutics for myeloid leukemia: modulating demethylase activity with ascorbate. PMID:33099992
Functional network analysis reveals potential repurposing of β-blocker atenolol for pancreatic cancer therapy. PMID:33098056
Mutations and mechanisms of WNT pathway tumour suppressors in cancer. PMID:33097916
Keap1 inhibition sensitizes head and neck squamous cell carcinoma cells to ionizing radiation via impaired non-homologous end joining and induced autophagy. PMID:33087706
Abundance of Regulatory T Cell (Treg) as a Predictive Biomarker for Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer. PMID:33086518
A Bioinformatic Pipeline Places STAT5A as a miR-650 Target in Poorly Differentiated Aggressive Breast Cancer. PMID:33086498
CKS2 and RMI2 are two prognostic biomarkers of lung adenocarcinoma. PMID:33083148
Validation and clinical application of a targeted next-generation sequencing gene panel for solid and hematologic malignancies. PMID:33083132
Bioinformatic analysis of the expression and prognostic value of chromobox family proteins in human breast cancer. PMID:33082469
Inhibiting insulin and mTOR signaling by afatinib and crizotinib combination fosters broad cytotoxic effects in cutaneous malignant melanoma. PMID:33082316
Multiomics integrative analysis for gene signatures and prognostic values of m6A regulators in pancreatic adenocarcinoma: a retrospective study in The Cancer Genome Atlas project. PMID:33082301
Common gene signatures and key pathways in hypopharyngeal and esophageal squamous cell carcinoma: Evidence from bioinformatic analysis. PMID:33080677
Cytosolic pH regulates proliferation and tumour growth by promoting expression of cyclin D1. PMID:33077976
Melanoma Stem Cell-Like Phenotype and Significant Suppression of Immune Response within a Tumor Are Regulated by TRIM28 Protein. PMID:33076560
Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression. PMID:33076392
SWI/SNF inactivation in the endometrial epithelium leads to loss of epithelial integrity. PMID:33075803
The prognostic significance of interferon-stimulated gene 15 (ISG15) in invasive breast cancer. PMID:33073304
RUNX2 interacts with BRG1 to target CD44 for promoting invasion and migration of colorectal cancer cells. PMID:33071648
Sunitinib in Patients with Metastatic Colorectal Cancer (mCRC) with FLT-3 Amplification: Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) Study. PMID:33068284
Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity. PMID:33067454
CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer. PMID:33066224
Gene amplification of YB-1 in castration-resistant prostate cancer in association with aberrant androgen receptor expression. PMID:33064355
MEK inhibition activates STAT signaling to increase breast cancer immunogenicity via MHC-I expression. PMID:33062958
Interactive Verification Analysis of Multiple Sequencing Data for Identifying Potential Biomarker of Lung Adenocarcinoma. PMID:33062704
Association Between Succinate Receptor SUCNR1 Expression and Immune Infiltrates in Ovarian Cancer. PMID:33062639
The role of m6A-related genes in the prognosis and immune microenvironment of pancreatic adenocarcinoma. PMID:33062408
Novel sequential treatment with palbociclib enhances the effect of cisplatin in RB-proficient triple-negative breast cancer. PMID:33061853
Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patients. PMID:33061814
Oleate acid-stimulated HMMR expression by CEBPα is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma. PMID:33061798
Identification and characterization of functional long noncoding RNAs in cancer. PMID:33058262
TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML. PMID:33057635
Clinical characteristics and prognostic implications of BRCA-associated tumors in males: a pan-tumor survey. PMID:33054725
Comprehensive Exome Analysis of Immunocompetent Metastatic Head and Neck Cancer Models Reveals Patient Relevant Landscapes. PMID:33053752
Estrogen Regulation of mTOR Signaling and Mitochondrial Function in Invasive Lobular Carcinoma Cell Lines Requires WNT4. PMID:33053661
In silico investigation of heparanase-correlated genes in breast cancer subtypes. PMID:33053017
POC1A acts as a promising prognostic biomarker associated with high tumor immune cell infiltration in gastric cancer. PMID:33052878
Characterization of the expression and prognostic value of 14-3-3 isoforms in breast cancer. PMID:33052135
Genotype-Phenotype Features of Germline Variants of the TMEM127 Pheochromocytoma Susceptibility Gene: A 10-Year Update. PMID:33051659
Clinicopathologic significance of protein lysine methyltransferases in cancer. PMID:33050946
Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors. PMID:33050470
Inhibition of ACK1 delays and overcomes acquired resistance of EGFR mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib. PMID:33049499
A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC. PMID:33049034
Identification of a prognostic gene signature based on an immunogenomic landscape analysis of bladder cancer. PMID:33048468
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD). PMID:33046988
Loss of ACSM3 confers worsened prognosis and immune exclusion to cutaneous melanoma. PMID:33046979
Deubiquitinase PSMD7 regulates cell fate and is associated with disease progression in breast cancer. PMID:33042429
Comprehensive characterization of functional eRNAs in lung adenocarcinoma reveals novel regulators and a prognosis-related molecular subtype. PMID:33042282
Association between copy-number alteration of +20q, -14q and -18p and cross-sensitivity to tyrosine kinase inhibitors in clear-cell renal cell carcinoma. PMID:33041663
Inhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer. PMID:33041328
CUP-AI-Dx: A tool for inferring cancer tissue of origin and molecular subtype using RNA gene-expression data and artificial intelligence. PMID:33039710
Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression. PMID:33039351
Spliceosomal factor mutations and mis-splicing in MDS. PMID:33038983
Allele-Specific Role of ERBB2 in the Oncogenic Function of EGFR L861Q in EGFR-Mutant Lung Cancers. PMID:33038514
Bioinformatic Identification of Potential Hub Genes in Muscle-Invasive Bladder Urothelial Carcinoma. PMID:33035117
Identification of a new pseudogenes/lncRNAs-hsa-miR-26b-5p-COL12A1 competing endogenous RNA network associated with prognosis of pancreatic cancer using bioinformatics analysis. PMID:33027767
ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells. PMID:33024871
Computational assessment of MCM2 transcriptional expression and identification of the prognostic biomarker for human breast cancer. PMID:33024849
Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome. PMID:33020491
Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. PMID:33020180
Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors. PMID:33016929
Identification of TYROBP and C1QB as Two Novel Key Genes With Prognostic Value in Gastric Cancer by Network Analysis. PMID:33014868
Discoidin Domain Receptors in Melanoma: Potential Therapeutic Targets to Overcome MAPK Inhibitor Resistance. PMID:33014862
Serpin peptidase inhibitor clade A member 1-overexpression in gastric cancer promotes tumor progression in vitro and is associated with poor prognosis. PMID:33014156
Knockdown of CSNK2ß suppresses MDA-MB231 cell growth, induces apoptosis, inhibits migration and invasion. PMID:33013272
Additional genetic alterations in BRAF-mutant gliomas correlate with histologic diagnoses. PMID:33009979
Biopathological Significance of PIWI-piRNA Pathway Deregulation in Invasive Breast Carcinomas. PMID:33008024
Transcriptome Profiling Reveals New Insights into the Immune Microenvironment and Upregulation of Novel Biomarkers in Metastatic Uveal Melanoma. PMID:33008022
MicroRNA-31 Regulates Expression of Wntless in Both Drosophila melanogaster and Human Oral Cancer Cells. PMID:33007980
Identification of Plasma Glycosphingolipids as Potential Biomarkers for Prostate Cancer (PCa) Status. PMID:33007922
Inflammatory Breast Cancer: Clinical Implications of Genomic Alterations and Mutational Profiling. PMID:33007869
Secretion of pro-oncogenic AGR2 protein in cancer. PMID:33005802
Regulating Methylation at H3K27: A Trick or Treat for Cancer Cell Plasticity. PMID:33003334
T follicular helper phenotype predicts response to histone deacetylase inhibitors in relapsed/refractory peripheral T-cell lymphoma. PMID:33002132
Role of serine 365 in BRAF V600E sensitivity to RAF inhibition. PMID:33000894
Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer. PMID:32999000
Omics-Based Platforms: Current Status and Potential Use for Cholangiocarcinoma. PMID:32998289
Two Sides of the Same Coin: The Roles of KLF6 in Physiology and Pathophysiology. PMID:32998281
The authors reply: Comment on "The expression landscape of cachexia-inducing factors in human cancers" by Freire et al. PMID:32996709
ITPKC as a Prognostic and Predictive Biomarker of Neoadjuvant Chemotherapy for Triple Negative Breast Cancer. PMID:32992708
Comprehensive Analysis of the Expression and Prognosis for SFRPs in Breast Carcinoma. PMID:32990024
Loss of UTX/KDM6A and the activation of FGFR3 converge to regulate differentiation gene-expression programs in bladder cancer. PMID:32989154
Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer. PMID:32988402
Beyond Traditional Morphological Characterization of Lung Neuroendocrine Neoplasms: In Silico Study of Next-Generation Sequencing Mutations Analysis across the Four World Health Organization Defined Groups. PMID:32987854
Role of POT1 in Human Cancer. PMID:32987645
Integrative Bioinformatics Analysis Reveals Potential Target Genes and TNFα Signaling Inhibition by Brazilin in Metastatic Breast Cancer Cells. PMID:32986377
The Construction of Bone Metastasis-Specific Prognostic Model and Co-expressed Network of Alternative Splicing in Breast Cancer. PMID:32984314
Complement C7 (C7), a Potential Tumor Suppressor, Is an Immune-Related Prognostic Biomarker in Prostate Cancer (PC). PMID:32984006
Enhanced Anticancer Effect of a Combination of S-adenosylmethionine (SAM) and Immune Checkpoint Inhibitor (ICPi) in a Syngeneic Mouse Model of Advanced Melanoma. PMID:32983966
Favorable Immune Microenvironment in Patients with EGFR and MAPK Co-Mutations. PMID:32982525
Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C. PMID:32980867
Overexpression of wild type or a Q311E mutant MB21D2 promotes a pro-oncogenic phenotype in HNSCC. PMID:32979859
Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz. PMID:32978601
EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer. PMID:32978523
Intrahepatic cholangiocarcinomas with IDH1/2 mutation-associated hypermethylation at selective genes and their clinicopathological features. PMID:32978444
Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor. PMID:32978388
A single-cell survey of cellular hierarchy in acute myeloid leukemia. PMID:32977829
Next-Generation Analytics for Omics Data. PMID:32976776
Multiple Chromoanasynthesis in a Rare Case of Sporadic Renal Leiomyosarcoma: A Case Report. PMID:32974204
Mutational Landscape of Esophageal Squamous Cell Carcinoma in an Indian Cohort. PMID:32974170
Comparison of Stage 4 and Stage 4s Neuroblastoma Identifies Autophagy-Related Gene and LncRNA Signatures Associated With Prognosis. PMID:32974147
Systemic Expression Analysis Reveals Prognostic Significance of WIPI3 in Hepatocellular Carcinoma. PMID:32973867
Comprehensive analysis on the expression levels and prognostic values of LOX family genes in kidney renal clear cell carcinoma. PMID:32970930
Prognostic landscape of tumor-infiltrating immune cells and immune-related genes in the tumor microenvironment of gastric cancer. PMID:32969836
Identification of diagnostic and prognostic biomarkers, and candidate targeted agents for hepatitis B virus-associated early stage hepatocellular carcinoma based on RNA-sequencing data. PMID:32968453
USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress. PMID:32968046
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. PMID:32966766
Multi-scale supervised clustering-based feature selection for tumor classification and identification of biomarkers and targets on genomic data. PMID:32962626
Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer. PMID:32962246
The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer. PMID:32957504
Targeting protein tyrosine kinase 6 in cancer. PMID:32956764
Analysis, identification and visualization of subgroups in genomics. PMID:32954413
Novel Potential Therapeutic Target for E2F1 and Prognostic Factors of E2F1/2/3/5/7/8 in Human Gastric Cancer. PMID:32953933
Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma. PMID:32951278
Association of PD-L1 and IDO1 expression with JAK-STAT pathway activation in soft-tissue leiomyosarcoma. PMID:32951108
Bioinformatics Data Mining Repurposes the JAK2 (Janus Kinase 2) Inhibitor Fedratinib for Treating Pancreatic Ductal Adenocarcinoma by Reversing the KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog)-Driven Gene Signature. PMID:32947833
Apolipoprotein C2 - CD36 Promotes Leukemia Growth and Presents a Targetable Axis in Acute Myeloid Leukemia. PMID:32944714
The critical role of BAP1 mutation in the prognosis and treatment selection of kidney renal clear cell carcinoma. PMID:32944533
N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours. PMID:32942614
Expression signature, prognosis value, and immune characteristics of Siglec-15 identified by pan-cancer analysis. PMID:32939323
Role of GATA3 exon 6 germline mutations in breast cancer progression in Egyptian female patients. PMID:32938228
Identification, Validation, and Functional Annotations of Genome-Wide Profile Variation between Melanocytic Nevus and Malignant Melanoma. PMID:32934956
Down syndrome iPSC model: endothelial perspective on tumor development. PMID:32934781
Identification of Key Prognostic Biomarker and Its Correlation with Immune Infiltrates in Pancreatic Ductal Adenocarcinoma. PMID:32934754
TMEM206 is a potential prognostic marker of hepatocellular carcinoma. PMID:32934741
Breast Cancer Cell Detection and Characterization from Breast Milk-Derived Cells. PMID:32934021
Intra-Tumoral Angiogenesis Is Associated with Inflammation, Immune Reaction and Metastatic Recurrence in Breast Cancer. PMID:32933189
FAM64A: A Novel Oncogenic Target of Lung Adenocarcinoma Regulated by Both Strands of miR-99a (miR-99a-5p and miR-99a-3p). PMID:32932948
Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis. PMID:32932846
Distinct cell-types in the prostate share an aging signature suggestive of metabolic reprogramming. PMID:32929410
Genome and transcriptome profiling of FBXW family in human prostate cancer. PMID:32929407
Triple Aberrant Prostate Cancer (TAPC) - Aggregate role of aberrations in TP53, PTEN and RB1 on ETS gene fusions and prognosis in metastatic castrate resistant prostate cancer. PMID:32929406
Tumor immune profiles noninvasively estimated by FDG PET with deep learning correlate with immunotherapy response in lung adenocarcinoma. PMID:32929383
EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy. PMID:32929368
HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma. PMID:32929358
Identification of glycogene-type and validation of ST3GAL6 as a biomarker predicts clinical outcome and cancer cell invasion in urinary bladder cancer. PMID:32929335
Histopathological imaging features- versus molecular measurements-based cancer prognosis modeling. PMID:32929170
Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney. PMID:32928875
HLA Class I Binding of Mutant EGFR Peptides in NSCLC Is Associated With Improved Survival. PMID:32927123
The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome. PMID:32926574
TENET 2.0: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma. PMID:32925947
Response of Brain Metastases From PIK3CA-Mutant Breast Cancer to Alpelisib. PMID:32923889
Comparison of Annotation Services for Next-Generation Sequencing in a Large-Scale Precision Oncology Program. PMID:32923873
METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth. PMID:32923617
Small extracellular vesicles modulated by αVβ3 integrin induce neuroendocrine differentiation in recipient cancer cells. PMID:32922691
ATM Mutations Benefit Bladder Cancer Patients Treated With Immune Checkpoint Inhibitors by Acting on the Tumor Immune Microenvironment. PMID:32922441
Identification of angiotensin-converting enzyme 2 (ACE2) protein as the potential biomarker in SARS-CoV-2 infection-related lung cancer using computational analyses. PMID:32916258
Using The Cancer Genome Atlas data to refine the 8th edition of the American Joint Committee on Cancer staging for papillary thyroid carcinoma. PMID:32915437
Mutational Landscape in Resected Periampullary Adenocarcinoma: Relationship With Morphology and Clinical Outcome. PMID:32914025
Genomic Analysis of Metastatic Solid Tumors in Veterans: Findings From the VHA National Precision Oncology Program. PMID:32914016
Genomic Resistance Patterns to Second-Generation Androgen Blockade in Paired Tumor Biopsies of Metastatic Castration-Resistant Prostate Cancer. PMID:32913968
Identification and validation of novel metastasis-related signatures of clear cell renal cell carcinoma using gene expression databases. PMID:32913492
Differences in tumour characteristics of Hepatocellular Carcinoma between patients with and without Cirrhosis: A population-based study. PMID:32913474
Systematic Analysis of the Clinical Relevance of Cell Division Cycle Associated Family in Endometrial Carcinoma. PMID:32913454
GMIEC: a shiny application for the identification of gene-targeted drugs for precision medicine. PMID:32912170
The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs. PMID:32911332
SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells. PMID:32909943
Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns. PMID:32907621
CCAAT/Enhancer-Binding Protein Delta (C/EBPδ): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells. PMID:32906832
Transcriptomic and functional pathway features were associated with survival after pathological complete response to neoadjuvant chemotherapy in breast cancer. PMID:32905537
The m6A readers YTHDF1 and YTHDF3 aberrations associated with metastasis and predict poor prognosis in breast cancer patients. PMID:32905518
Integrative Analysis of the IQ Motif-Containing GTPase-Activating Protein Family Indicates That the IQGAP3-PIK3C2B Axis Promotes Invasion in Colon Cancer. PMID:32903879
Rho GDP-Dissociation Inhibitor 2 Inhibits C-X-C Chemokine Receptor Type 4-Mediated Acute Lymphoblastic Leukemia Cell Migration. PMID:32903764
Artificial Intelligence to Decode Cancer Mechanism: Beyond Patient Stratification for Precision Oncology. PMID:32903628
Prognosis of Lung Adenocarcinoma Patients With NTRK3 Mutations to Immune Checkpoint Inhibitors. PMID:32903385
CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes. PMID:32900797
Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma. PMID:32899449
RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling. PMID:32899426
Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples. PMID:32899175
Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression. PMID:32895052
Identification of a metabolism-related gene expression prognostic model in endometrial carcinoma patients. PMID:32894095
CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade. PMID:32887696
A hypoxia-related signature for clinically predicting diagnosis, prognosis and immune microenvironment of hepatocellular carcinoma patients. PMID:32887635
Prognostic Values for the mRNA Expression of the ADAMTS Family of Genes in Gastric Cancer. PMID:32884571
CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus-Associated Head and Neck Cancers. PMID:32883697
Genomics and Functional Genomics of Malignant Pleural Mesothelioma. PMID:32882916
Cancer-Specific Immune Prognostic Signature in Solid Tumors and Its Relation to Immune Checkpoint Therapies. PMID:32882873
Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development in the Drosophila larval brain. PMID:32878945
Most Commonly Mutated Genes in High-Grade Serous Ovarian Carcinoma Are Nonessential for Ovarian Surface Epithelial Stem Cell Transformation. PMID:32877668
Immortalization of human primary prostate epithelial cells via CRISPR inactivation of the CDKN2A locus and expression of telomerase. PMID:32873916
The HMGB1-2 Ovarian Cancer Interactome. The Role of HMGB Proteins and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and Drug-Response. PMID:32867128
Roles for MDC1 in cancer development and treatment. PMID:32866776
Transcriptional and immunohistological assessment of immune infiltration in pancreatic cancer. PMID:32866185
Aberrant RNA Splicing in Cancer. PMID:32864546
Chromatin remodelling comes into focus. PMID:32864100
m6A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer. PMID:32863943
Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets. PMID:32863893
27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression. PMID:32861706
Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer. PMID:32860789
β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion. PMID:32860047
XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition. PMID:32859985
Impact of genetic alterations on outcomes of patients with stage I nonsmall cell lung cancer: An analysis of the cancer genome atlas data. PMID:32857918
Germline DNMT3A mutation in familial acute myeloid leukaemia. PMID:32856987
DLBCL with amplification of JAK2/PD-L2 exhibits PMBCL-like CNA pattern and worse clinical outcome resembling those with MYD88 L265P mutation. PMID:32854650
Detection of Germline Mutations in a Cohort of 139 Patients with Bilateral Breast Cancer by Multi-Gene Panel Testing: Impact of Pathogenic Variants in Other Genes beyond BRCA1/2. PMID:32854451
Biological Landscape of Triple Negative Breast Cancers Expressing CTLA-4. PMID:32850353
Genetic Alterations and Transcriptional Expression of m6A RNA Methylation Regulators Drive a Malignant Phenotype and Have Clinical Prognostic Impact in Hepatocellular Carcinoma. PMID:32850303
Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers. PMID:32847042
An immune scores-based nomogram for predicting overall survival in patients with clear cell renal cell carcinoma. PMID:32846785
Association of MUC16 Mutation With Response to Immune Checkpoint Inhibitors in Solid Tumors. PMID:32845327
A robust 11-genes prognostic model can predict overall survival in bladder cancer patients based on five cohorts. PMID:32843852
Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma. PMID:32843721
Endometrial Cancer as a Metabolic Disease with Dysregulated PI3K Signaling: Shedding Light on Novel Therapeutic Strategies. PMID:32842547
Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate. PMID:32839463
DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas. PMID:32838940
Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain. PMID:32838755
Protein kinase A inhibitor proteins (PKIs) divert GPCR-Gαs-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth. PMID:32830375
Expression Profile and Prognostic Values of Mini-Chromosome Maintenance Families (MCMs) in Breast Cancer. PMID:32830194
OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity. PMID:32826889
Neoadjuvant metformin added to conventional chemotherapy synergizes anti-proliferative effects in ovarian cancer. PMID:32825834
Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications. PMID:32825279
Role of Adipose Tissue-Derived Autotaxin, Lysophosphatidate Signaling, and Inflammation in the Progression and Treatment of Breast Cancer. PMID:32824846
Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3. PMID:32824461
Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer. PMID:32824360
YB-1 Knockdown Inhibits the Proliferation of Mesothelioma Cells through Multiple Mechanisms. PMID:32823952
Clonal Hematopoiesis in Liquid Biopsy: From Biological Noise to Valuable Clinical Implications. PMID:32823942
Cyclin E2 Promotes Whole Genome Doubling in Breast Cancer. PMID:32823571
Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing. PMID:32822576
Coordinated dysregulation of cancer progression by the HER family and p21-activated kinases. PMID:32820388
Hippo/MST blocks breast cancer by downregulating WBP2 oncogene expression via miRNA processor Dicer. PMID:32820148
Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression. PMID:32820145
Down-regulation of tenascin-C inhibits breast cancer cells development by cell growth, migration, and adhesion impairment. PMID:32817625
A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers. PMID:32817551
SUMOylation of E2F1 Regulates Expression of EZH2. PMID:32816857
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition. PMID:32816843
Deficiency of pseudogene UPAT leads to hepatocellular carcinoma progression and forms a positive feedback loop with ZEB1. PMID:32808348
FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity. PMID:32807875
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints. PMID:32807787
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice. PMID:32807776
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy. PMID:32807225
Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer. PMID:32807223
1-Chromonyl-5-Imidazolylpentadienone Demonstrates Anti-Cancer Action against TNBC and Exhibits Synergism with Paclitaxel. PMID:32806551
Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma. PMID:32801999
Analyses of DNA Methylation Involved in the Activation of Nuclear Karyopherin Alpha 2 Leading to Identify the Progression and Prognostic Significance Across Human Breast Cancer. PMID:32801900
Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. PMID:32796891
Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1. PMID:32796628
Expression of p42.3 in non-small cell lung cancer. PMID:32793664
An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants. PMID:32792368
Subunits of ARID1 serve as novel biomarkers for the sensitivity to immune checkpoint inhibitors and prognosis of advanced non-small cell lung cancer. PMID:32791957
The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma. PMID:32791233
PARP Inhibitors and Prostate Cancer: To Infinity and Beyond BRCA. PMID:32790034
Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide. PMID:32785847
Design and Testing of a Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA. PMID:32785074
Pre-Existing Tumoral B Cell Infiltration and Impaired Genome Maintenance Correlate with Response to Chemoradiotherapy in Locally Advanced Rectal Cancer. PMID:32784964
Notch Transduction in Non-Small Cell Lung Cancer. PMID:32784481
High expression of EMP1 predicts a poor prognosis and correlates with immune infiltrates in bladder urothelial carcinoma. PMID:32782602
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. PMID:32782249
Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer. PMID:32781581
A compendium of mutational cancer driver genes. PMID:32778778
Expanding cancer predisposition genes with ultra-rare cancer-exclusive human variations. PMID:32778766
Current Status of SUMOylation Inhibitors. PMID:32778019
Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer. PMID:32777161
Associations of novel variants in PIK3C3, INSR and MAP3K4 of the ATM pathway genes with pancreatic cancer risk. PMID:32775006
Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast cancer. PMID:32774770
Prognostic value and therapeutic implications of ZHX family member expression in human gastric cancer. PMID:32774706
Somatic mutations in genes associated with mismatch repair predict survival in patients with metastatic cancer receiving immune checkpoint inhibitors. PMID:32774500
Integrated genetic and epigenetic analysis of cancer-related genes in non-ampullary duodenal adenomas and intramucosal adenocarcinomas. PMID:32770675
Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis. PMID:32768595
A phase 2 trial of buparlisib in patients with platinum-resistant metastatic urothelial carcinoma. PMID:32767682
The molecular functions of RIT1 and its contribution to human disease. PMID:32766847
Bioinformatics analysis shows that TOP2A functions as a key candidate gene in the progression of cervical cancer. PMID:32765860
Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer. PMID:32765584
Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence. PMID:32764696
iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome. PMID:32764607
Alternative splicing reverses the cell-intrinsic and cell-extrinsic pro-oncogenic potentials of YAP1. PMID:32763976
High frequency of exon 20 S768I EGFR mutation detected in malignant pleural effusions: A poor prognosticator of NSCLC. PMID:32761886
ROS1-dependent cancers - biology, diagnostics and therapeutics. PMID:32760015
EPHA5 mutation predicts the durable clinical benefit of immune checkpoint inhibitors in patients with lung adenocarcinoma. PMID:32759987
Comprehensive Analysis of Expression, Clinicopathological Association and Potential Prognostic Significance of RABs in Pancreatic Cancer. PMID:32759795
Collagen Type III Alpha 1 chain regulated by GATA-Binding Protein 6 affects Type II IFN response and propanoate metabolism in the recurrence of lower grade glioma. PMID:32757451
Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant. PMID:32756902
The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency. PMID:32755579
Myc linked to dysregulation of cholesterol transport and storage in nonsmall cell lung cancer. PMID:32753459
Unravelling the Role of miR-20b-5p, CCNB1, HMGA2 and E2F7 in Development and Progression of Non-Small Cell Lung Cancer (NSCLC). PMID:32752229
PLEKHS1 Over-Expression is Associated with Metastases and Poor Outcomes in Papillary Thyroid Carcinoma. PMID:32752127
Genomic Database Analysis of Uterine Leiomyosarcoma Mutational Profile. PMID:32751892
Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy. PMID:32751840
Oncogenic Serine 45-Deleted β-Catenin Remains Susceptible to Wnt Stimulation and APC Regulation in Human Colonocytes. PMID:32751567
Metastasis of Uveal Melanoma with Monosomy-3 Is Associated with a Less Glycogenetic Gene Expression Profile and the Dysregulation of Glycogen Storage. PMID:32751097
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer. PMID:32749453
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes. PMID:32747829
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy. PMID:32747819
Prognostic implication and functional annotations of APOBEC3G expression in patients with Melanoma. PMID:32742470
Aberrant methylation and microRNA-target regulation are associated with downregulated NEURL1B: a diagnostic and prognostic target in colon cancer. PMID:32742189
Molecular profiling of immune cell-enriched Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) interacting protein USP13. PMID:32735883
Identification of candidate mediators of chemoresponse in breast cancer through therapy-driven selection of somatic variants. PMID:32734521
Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma. PMID:32733646
X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis. PMID:32732223
Comprehensive Cohort Analysis of Mutational Spectrum in Early Onset Breast Cancer Patients. PMID:32731431
An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. PMID:32729927
Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities. PMID:32727735
PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas. PMID:32727536
Identification of hub genes involved in the occurrence and development of hepatocellular carcinoma via bioinformatics analysis. PMID:32724412
Mining the prognostic significance of the GINS2 gene in human breast cancer using bioinformatics analysis. PMID:32724372
PD-L1 expression increased by IFN-γ via JAK2-STAT1 signaling and predicts a poor survival in colorectal cancer. PMID:32724352
Neratinib in patients with HER2-mutant, metastatic cervical cancer: Findings from the phase 2 SUMMIT basket trial. PMID:32723675
PARP Inhibitor Resistance Mechanisms and Implications for Post-Progression Combination Therapies. PMID:32722408
Pan-Cancer Analysis of the Genomic Alterations and Mutations of the Matrisome. PMID:32722287
Comprehensive Genomic Analysis Reveals the Prognostic Role of LRRK2 Copy-Number Variations in Human Malignancies. PMID:32722212
Transcriptomic Profile of Lymphovascular Invasion, a Known Risk Factor of Pancreatic Ductal Adenocarcinoma Metastasis. PMID:32722116
Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. PMID:32721948
RAS/MAPK Pathway Driver Alterations Are Significantly Associated With Oncogenic KIT Mutations in Germ-cell Tumors. PMID:32721511
Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal adenocarcinoma. PMID:32719550
Comprehensive analysis of the expression and prognosis for CDCAs in head and neck squamous cell carcinoma. PMID:32716971
Construction of a novel prognostic-predicting model correlated to ovarian cancer. PMID:32716025
Cancer-Testis Gene Expression in Hepatocellular Carcinoma: Identification of Prognostic Markers and Potential Targets for Immunotherapy. PMID:32715976
Development and implementation of the SUM breast cancer cell line functional genomics knowledge base. PMID:32715085
Characterisation of Ovarian Cancer Cell Line NIH-OVCAR3 and Implications of Genomic, Transcriptomic, Proteomic and Functional DNA Damage Response Biomarkers for Therapeutic Targeting. PMID:32709004
TCGA Pan-Cancer Genomic Analysis of Alternative Lengthening of Telomeres (ALT) Related Genes. PMID:32708340
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer. PMID:32708015
Chemically Induced Hypoxia Enhances miRNA Functions in Breast Cancer. PMID:32707933
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution. PMID:32707077
FAK inhibition radiosensitizes pancreatic ductal adenocarcinoma cells in vitro. PMID:32705304
Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma. PMID:32704163
Identifying the novel key genes in renal cell carcinoma by bioinformatics analysis and cell experiments. PMID:32699530
Establishment of the prognostic index of lung squamous cell carcinoma based on immunogenomic landscape analysis. PMID:32699529
Establishment of a novel cell cycle-related prognostic signature predicting prognosis in patients with endometrial cancer. PMID:32699528
Integration of Genomic Medicine in Pathology Resident Training. PMID:32696061
Novel Potential Biomarkers Associated With Epithelial to Mesenchymal Transition and Bladder Cancer Prognosis Identified by Integrated Bioinformatic Analysis. PMID:32695668
SFRP1 increases TMPRSS2-ERG expression promoting neoplastic features in prostate cancer in vitro and in vivo. PMID:32694934
Selenium detoxification is required for cancer-cell survival. PMID:32694795
Identifying strategies to target the metabolic flexibility of tumours. PMID:32694609
Bioinformatics analysis of gene expression profile of serous ovarian carcinomas to screen key genes and pathways. PMID:32693821
Increased nuclear factor I/B expression in prostate cancer correlates with AR expression. PMID:32692871
PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells. PMID:32692719
BRD4 regulates key transcription factors that drive epithelial-mesenchymal transition in castration-resistant prostate cancer. PMID:32690869
BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency. PMID:32690724
Clinical significance of EPHX2 deregulation in prostate cancer. PMID:32687069
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. PMID:32686647
Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in Stomach Adenocarcinoma. PMID:32685482
Combined analysis of RNA-sequence and microarray data reveals effective metabolism-based prognostic signature for neuroblastoma. PMID:32683778
Analysis of the "centrosome-ome" identifies MCPH1 deletion as a cause of centrosome amplification in human cancer. PMID:32681070
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer. PMID:32679108
TGFβ2-mediated epithelial-mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance. PMID:32678313
Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer. PMID:32678307
Class IA PI3K regulatory subunits: p110-independent roles and structures. PMID:32677674
Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma. PMID:32676580
Radiomics Features Predict CIC Mutation Status in Lower Grade Glioma. PMID:32676453
Prostate cancer biology & genomics. PMID:32676435
The prognostic value and potential mechanism of Matrix Metalloproteinases among Prostate Cancer. PMID:32669958
Disparate survival of late-stage male oropharyngeal cancer in Appalachia. PMID:32669588
CCR2 of Tumor Microenvironmental Cells Is a Relevant Modulator of Glioma Biology. PMID:32668709
Analysis of the expression and genetic alteration of CLDN18 in gastric cancer. PMID:32668412
Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma. PMID:32667929
The roles of histone variants in fine-tuning chromatin organization and function. PMID:32665685
ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader-Follower Relationship That Drives Collective Invasion. PMID:32661136
High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients. PMID:32658903
Analysis of deubiquitinase OTUD5 as a biomarker and therapeutic target for cervical cancer by bioinformatic analysis. PMID:32655987
ZFHX3 mutation as a protective biomarker for immune checkpoint blockade in non-small cell lung cancer. PMID:32653938
A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma. PMID:32651364
Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency. PMID:32651270
Cell Lineage-Based Stratification for Glioblastoma. PMID:32649888
The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer. PMID:32649682
Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea. PMID:32649211
Novel monoclonal antibody against integrin α3 shows therapeutic potential for ovarian cancer. PMID:32648337
Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells. PMID:32647287
Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution. PMID:32647202
MicroRNAs as Guardians of the Prostate: Those Who Stand before Cancer. What Do We Really Know about the Role of microRNAs in Prostate Biology? PMID:32645914
Association of Independent Prognostic Factors and Treatment Modality With Survival and Recurrence Outcomes in Breast Cancer. PMID:32644137
BRIT1 dysfunction confers synergistic inhibition of hepatocellular carcinoma by targeting poly (ADP-ribose) polymerases and PI3K. PMID:32642299
Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis. PMID:32640634
Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene. PMID:32639993
Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade. PMID:32639068
Characterization of TNNC1 as a Novel Tumor Suppressor of Lung Adenocarcinoma. PMID:32638704
Prognostic Significance of the Pluripotency Factors NANOG, SOX2, and OCT4 in Head and Neck Squamous Cell Carcinomas. PMID:32635524
Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma. PMID:32635224
Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design. PMID:32634377
MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC. PMID:32634121
Bioinformatics analysis of high-throughput data to validate potential novel biomarkers and small molecule drugs for glioblastoma multiforme. PMID:32634050
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling. PMID:32630372
L1CAM, CA9, KLK6, HPN, and ALDH1A1 as Potential Serum Markers in Primary and Metastatic Colorectal Cancer Screening. PMID:32630086
Contribution of Immune Cells to Glucocorticoid Receptor Expression in Breast Cancer. PMID:32629782
Application of cAMP-dependent catalytic subunit β (PRKACB) Low Expression in Predicting Worse Overall Survival: A Potential Therapeutic Target for Colorectal Carcinoma. PMID:32626531
Development and validation of a novel immune-related prognostic model in lung squamous cell carcinoma. PMID:32624696
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target. PMID:32620742
Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions. PMID:32619551
A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue. PMID:32619021
Sustained response to pembrolizumab without prior chemotherapy in high-grade serous ovarian carcinoma with CSMD3 mutation. PMID:32613071
The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer. PMID:32612943
Evaluation of Gene Expression Data From Cybrids and Tumours Highlights Elevated NDRG1-Driven Proliferation in Triple-Negative Breast Cancer. PMID:32612361
miRNA Clusters with Down-Regulated Expression in Human Colorectal Cancer and Their Regulation. PMID:32610706
PTEN Protein Loss and Loss-of-Function Mutations in Gastric Cancers: The Relationship with Microsatellite Instability, EBV, HER2, and PD-L1 Expression. PMID:32610572
KIT and Melanoma: Biological Insights and Clinical Implications. PMID:32608199
ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells. PMID:32606936
Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes. PMID:32605315
Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer. PMID:32603375
Glioma escape signature and clonal development under immune pressure. PMID:32603315
Functional network analysis reveals an immune tolerance mechanism in cancer. PMID:32601217
Tumor Immune Microenvironment Clusters in Localized Prostate Adenocarcinoma: Prognostic Impact of Macrophage Enriched/Plasma Cell Non-Enriched Subtypes. PMID:32599760
Elevated expression of minichromosome maintenance 3 indicates poor outcomes and promotes G1/S cell cycle progression, proliferation, migration and invasion in colorectal cancer. PMID:32597491
miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway. PMID:32596290
Intrinsic and Extrinsic Factors Governing the Transcriptional Regulation of ESR1. PMID:32592004
Systematic Analysis of Spleen Tyrosine Kinase Expression and its Clinical Outcomes in Various Cancers. PMID:32587490
Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer. PMID:32586284
Molecular genetic profiling reveals novel association between FLT3 mutation and survival in glioma. PMID:32583303
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development. PMID:32579928
The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development. PMID:32576626
Phosphodiesterase SMPDL3B Gene Expression as Independent Outcome Prediction Marker in Localized Prostate Cancer. PMID:32575490
Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells. PMID:32571254
ZEB1/miR-200c/AGR2: A New Regulatory Loop Modulating the Epithelial-Mesenchymal Transition in Lung Adenocarcinomas. PMID:32570918
Rare Tumor-Normal Matched Whole Exome Sequencing Identifies Novel Genomic Pathogenic Germline and Somatic Aberrations. PMID:32570879
AML chemoresistance: The role of mutant TP53 subclonal expansion and therapy strategy. PMID:32569759
Prevalence of disease-causing genes in Japanese patients with BRCA1/2-wildtype hereditary breast and ovarian cancer syndrome. PMID:32566746
Bioinformatics analysis of prognosis-related long non-coding RNAs in invasive breast carcinoma. PMID:32565939
FAM83H and SCRIB stabilize β-catenin and stimulate progression of gastric carcinoma. PMID:32564009
Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice. PMID:32561853
The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways. PMID:32561656
Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress. PMID:32559414
CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma. PMID:32555149
Association of molecular characteristics with survival in advanced non-small cell lung cancer patients treated with checkpoint inhibitors. PMID:32554069
MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans. PMID:32553107
Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer. PMID:32552862
Ubiquilin Networking in Cancers. PMID:32549375
Big Data-Based Identification of Multi-Gene Prognostic Signatures in Liver Cancer. PMID:32547951
Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach. PMID:32546937
MicroRNA-17-5p regulates EMT by targeting vimentin in colorectal cancer. PMID:32546833
Cotargeting of XPO1 Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Acute Myeloid Leukemia. PMID:32545904
Neutrophil Extracellular Traps (NETs) Promote Pro-Metastatic Phenotype in Human Breast Cancer Cells through Epithelial-Mesenchymal Transition. PMID:32545405
(-)-Oleocanthal as a Dual c-MET-COX2 Inhibitor for the Control of Lung Cancer. PMID:32545325
Unveiling prognostics biomarkers of tyrosine metabolism reprogramming in liver cancer by cross-platform gene expression analyses. PMID:32542016
Gene expression and prognosis of sirtuin family members in ovarian cancer. PMID:32541517
HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma. PMID:32540961
Molecular Landscape of BRAF-Mutant NSCLC Reveals an Association Between Clonality and Driver Mutations and Identifies Targetable Non-V600 Driver Mutations. PMID:32540409
Identification of methylation-driven genes related to the prognosis of papillary renal cell carcinoma: a study based on The Cancer Genome Atlas. PMID:32536823
Comprehensive analysis of LDHAP5 pseudogene expression and potential pathogenesis in ovarian serous cystadenocarcinoma. PMID:32536817
Why Great Mitotic Inhibitors Make Poor Cancer Drugs. PMID:32536592
Deep learning-based classification and mutation prediction from histopathological images of hepatocellular carcinoma. PMID:32536036
Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma. PMID:32534597
Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator. PMID:32533515
Mediator complex subunit 16 is down-regulated in papillary thyroid cancer, leading to increased transforming growth factor-β signaling and radioiodine resistance. PMID:32532820
Update on GNA Alterations in Cancer: Implications for Uveal Melanoma Treatment. PMID:32532044
Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells. PMID:32528731
miR-410 induces both epithelial-mesenchymal transition and radioresistance through activation of the PI3K/mTOR pathway in non-small cell lung cancer. PMID:32528035
Tissue- and development-stage-specific mRNA and heterogeneous CNV signatures of human ribosomal proteins in normal and cancer samples. PMID:32525984
Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells. PMID:32525891
Myotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma. PMID:32522977
Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer. PMID:32521267
Oncogenic Gene-Expression Programs in Leiomyosarcoma and Characterization of Conventional, Inflammatory, and Uterogenic Subtypes. PMID:32518213
Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein. PMID:32518090
Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression. PMID:32517178
Long Non-Coding RNA HAND2-AS1 Acts as a Tumor Suppressor in High-Grade Serous Ovarian Carcinoma. PMID:32517089
MET-dependent solid tumours - molecular diagnosis and targeted therapy. PMID:32514147
Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells. PMID:32513814
Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma. PMID:32513387
Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes. PMID:32513296
An Overview of Candidate Therapeutic Target Genes in Ovarian Cancer. PMID:32512900
Omics Integration Analyses Reveal the Early Evolution of Malignancy in Breast Cancer. PMID:32512721
G9a Is SETting the Stage for Colorectal Oncogenesis. PMID:32512705
Identifying multiple collagen gene family members as potential gastric cancer biomarkers using integrated bioinformatics analysis. PMID:32509452
Identification of SOCS family members with prognostic values in human ovarian cancer. PMID:32509179
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint. PMID:32508832
Calreticulin couples with immune checkpoints in pancreatic cancer. PMID:32508042
HK3 is correlated with immune infiltrates and predicts response to immunotherapy in non-small cell lung cancer. PMID:32508023
Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination. PMID:32502392
Unleashing the Diagnostic, Prognostic and Therapeutic Potential of the Neuronostatin/GPR107 System in Prostate Cancer. PMID:32498336
WHSC1 monomethylates histone H1 and induces stem-cell like features in squamous cell carcinoma of the head and neck. PMID:32497898
In vivo modeling of metastatic human high-grade serous ovarian cancer in mice. PMID:32497036
Co-Regulation of Immune Checkpoint PD-L1 with Interferon-Gamma Signaling is Associated with a Survival Benefit in Renal Cell Cancer. PMID:32495158
Identification of prognostic gene biomarkers for metastatic skin cancer using data mining. PMID:32494360
RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability. PMID:32494026
GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors. PMID:32493985
FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors. PMID:32493400
FGFR4: A promising therapeutic target for breast cancer and other solid tumors. PMID:32492514
Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in lung cancer. PMID:32492203
Lysophosphatidic acid reverses Temsirolimus-induced changes in lipid droplets and mitochondrial networks in renal cancer cells. PMID:32492043
Study of Caspase 8 mutation in oral cancer and adjacent precancer tissues and implication in progression. PMID:32492030
Radiomics-based nomogram using CT imaging for noninvasive preoperative prediction of early recurrence in patients with hepatocellular carcinoma. PMID:32490826
Guizhi Fuling Decoction inhibiting the PI3K and MAPK pathways in breast cancer cells revealed by HTS2 technology and systems pharmacology. PMID:32489526
Blood-based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Pancreatic Cancer and its Value to Guide Clinical Treatment. PMID:32489450
Nine glycolysis-related gene signature predicting the survival of patients with endometrial adenocarcinoma. PMID:32489319
Fibroblasts as a Biological Marker for Curative Resection in Pancreatic Ductal Adenocarcinoma. PMID:32485981
TRPM4 is overexpressed in breast cancer associated with estrogen response and epithelial-mesenchymal transition gene sets. PMID:32484822
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer. PMID:32483383
Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival. PMID:32481602
A Novel Nomogram Based on Immune Scores for Predicting Survival in Patients with Early-Stage Non-Small Cell Lung Cancer (NSCLC). PMID:32479428
Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models. PMID:32478869
Co-Occurring Alterations of ERBB2 Exon 20 Insertion in Non-Small Cell Lung Cancer (NSCLC) and the Potential Indicator of Response to Afatinib. PMID:32477948
Multifaceted regulation of Notch signaling by glycosylation. PMID:32472127
The Tumor Suppressor TGFBR3 Blocks Lymph Node Metastasis in Head and Neck Cancer. PMID:32471132
Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers. PMID:32467608
Strategies for Functional Interrogation of Big Cancer Data Using Drosophila Cancer Models. PMID:32466549
Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases. PMID:32462403
The SLC Family Are Candidate Diagnostic and Prognostic Biomarkers in Clear Cell Renal Cell Carcinoma. PMID:32461965
Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes. PMID:32461624
Epigenetic downregulation of desmin in gall bladder cancer reveals its potential role in disease progression. PMID:32461394
Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma. PMID:32460791
RAC1 as a Therapeutic Target in Malignant Melanoma. PMID:32460002
Immunoscore Predicts Survival in Early-Stage Lung Adenocarcinoma Patients. PMID:32457841
Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer. PMID:32457491
Molecular patterns in salivary duct carcinoma identify prognostic subgroups. PMID:32457410
An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer. PMID:32455963
Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer. PMID:32455851
ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer. PMID:32454461
An up-to-date overview of computational polypharmacology in modern drug discovery. PMID:32452701
CVCDAP: an integrated platform for molecular and clinical analysis of cancer virtual cohorts. PMID:32449936
Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival. PMID:32445177
Visualizing and interpreting cancer genomics data via the Xena platform. PMID:32444850
Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks. PMID:32444848
SNHG7 is a lncRNA oncogene controlled by Insulin-like Growth Factor signaling through a negative feedback loop to tightly regulate proliferation. PMID:32444795
Loss of Spry1 reduces growth of BRAFV600-mutant cutaneous melanoma and improves response to targeted therapy. PMID:32444628
Screening and identification of key biomarkers for retinoblastoma: Evidence from bioinformatics analysis. PMID:32443297
The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer. PMID:32440535
Targeting eIF3f Suppresses the Growth of Prostate Cancer Cells by Inhibiting Akt Signaling. PMID:32440143
Core Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network. PMID:32439761
First-line pembrolizumab and trastuzumab in HER2-positive oesophageal, gastric, or gastro-oesophageal junction cancer: an open-label, single-arm, phase 2 trial. PMID:32437664
Proliferation-associated long noncoding RNA, TMPO-AS1, is a potential therapeutic target for triple-negative breast cancer. PMID:32437068
Molecular Biological Features of Nottingham Histological Grade 3 Breast Cancers. PMID:32436191
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth. PMID:32433953
Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that PTEN Loss Contributes to Cetuximab Resistance in Head and Neck Cancer. PMID:32430488
Direct comparison shows that mRNA-based diagnostics incorporate information which cannot be learned directly from genomic mutations. PMID:32429832
Epigenetic Alterations in Oesophageal Cancer: Expression and Role of the Involved Enzymes. PMID:32429269
A novel role for NUAK1 in promoting ovarian cancer metastasis through regulation of fibronectin production in spheroids. PMID:32429240
SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation. PMID:32427938
Detecting Cancer Survival Related Gene Markers Based on Rectified Factor Network. PMID:32426342
Identification of potential novel differentially-expressed genes and their role in invasion and migration in renal cell carcinoma. PMID:32420905
Characterization of FANCL variants observed in patient cancer cells. PMID:32420600
Screening and Identification of Differentially Expressed Genes Expressed among Left and Right Colon Adenocarcinoma. PMID:32420374
Long-term survival with targeted therapy in an advanced non-small cell lung cancer patient based on genetic profiling. PMID:32420078
Integrative Analysis of Periostin in Primary and Advanced Prostate Cancer. PMID:32416542
Performance of four platforms for KRAS mutation detection in plasma cell-free DNA: ddPCR, Idylla, COBAS z480 and BEAMing. PMID:32415199
CRISPR screening identifies M1AP as a new MYC regulator with a promoter-reporter system. PMID:32411526
Sulfiredoxin as a Potential Therapeutic Target for Advanced and Metastatic Prostate Cancer. PMID:32411320
Mining the role of angiopoietin-like protein family in gastric cancer and seeking potential therapeutic targets by integrative bioinformatics analysis. PMID:32410376
Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model. PMID:32408898
Identification of transforming growth factor beta induced (TGFBI) as an immune-related prognostic factor in clear cell renal cell carcinoma (ccRCC). PMID:32406866
GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17. PMID:32405532
Frequency and spectrum of PIK3CA somatic mutations in breast cancer. PMID:32404150
HIP1R Expression and Its Association with PD-1 Pathway Blockade Response in Refractory Advanced NonSmall Cell Lung Cancer: A Gene Set Enrichment Analysis. PMID:32403421
Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies. PMID:32403323
In silico analyses identify lncRNAs: WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors. PMID:32401758
CD37 high expression as a potential biomarker and association with poor outcome in acute myeloid leukemia. PMID:32400873
Diagnostic, progressive and prognostic performance of m6A methylation RNA regulators in lung adenocarcinoma. PMID:32398949
Systematic Multiomic Analysis of Ly75 Gene Expression and Its Prognostic Value Through the Infiltration of Natural Killer (NK) Cells in Skin Cutaneous Melanoma. PMID:32397120
Emerging Therapeutic Implications of STK11 Mutation: Case Series. PMID:32396674
Lower Levels of Adiponectin and Its Receptor Adipor1 in the Uveal Melanomas With Monosomy-3. PMID:32396633
CD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancer. PMID:32395395
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. PMID:32393580
Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation. PMID:32393311
E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells. PMID:32391871
The roles of MASPIN expression and subcellular localization in non-small cell lung cancer. PMID:32391558
PBRM1 suppresses tumor growth as a novel p53 acetylation reader. PMID:32391422
Progesterone receptor promotes degradation of STAT2 to inhibit the interferon response in breast cancer. PMID:32391191
Epididymal protein 3A is upregulated and promotes cell proliferation in non-small cell lung cancer. PMID:32391105
Elevated TNFRSF4 gene expression is a predictor of poor prognosis in non-M3 acute myeloid leukemia. PMID:32390761
Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation. PMID:32386122
p85β regulates autophagic degradation of AXL to activate oncogenic signaling. PMID:32385243
Analysis of TP53 aflatoxin signature mutation in hepatocellular carcinomas from Guatemala: A cross-sectional study (2016-2017). PMID:32382660
Expression of yhwaz and gene regulation network in hepatocellular carcinoma. PMID:32382342
Overexpression of LBX2 associated with tumor progression and poor prognosis in colorectal cancer. PMID:32382328
MUC15 inhibits cancer metastasis via PI3K/AKT signaling in renal cell carcinoma. PMID:32382053
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling. PMID:32381551
CCNE1 Amplification as a Predictive Biomarker of Chemotherapy Resistance in Epithelial Ovarian Cancer. PMID:32380689
Identification and validation of the angiogenic genes for constructing diagnostic, prognostic, and recurrence models for hepatocellular carcinoma. PMID:32379058
Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells. PMID:32377817
Androgen attenuates the inactivating phospho-Ser-127 modification of yes-associated protein 1 (YAP1) and promotes YAP1 nuclear abundance and activity. PMID:32376689
The molecular basis of selective DNA binding by the BRG1 AT-hook and bromodomain. PMID:32376391
A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer. PMID:32371585
Establishment and Validation of an Individualized Cell Cycle Process-Related Gene Signature to Predict Cancer-Specific Survival in Patients with Bladder Cancer. PMID:32370292
Molecular Signatures of JMJD10/MINA53 in Gastric Cancer. PMID:32370161
Complement factor H-deficient mice develop spontaneous hepatic tumors. PMID:32369457
The roles and mechanisms of YTH domain-containing proteins in cancer development and progression. PMID:32368386
IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils. PMID:32366475
The Influence of Methylating Mutations on Acute Myeloid Leukemia: Preliminary Analysis on 56 Patients. PMID:32365516
Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases. PMID:32365229
Regulation of eIF2α by RNF4 Promotes Melanoma Tumorigenesis and Therapy Resistance. PMID:32360601
Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth. PMID:32358581
Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer. PMID:32357907
The Clinical Significance of PIWIL3 and PIWIL4 Expression in Pancreatic Cancer. PMID:32357464
Development of a prognostic index of colon adenocarcinoma based on immunogenomic landscape analysis. PMID:32355728
DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres. PMID:32355220
Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity. PMID:32355214
Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish. PMID:32354205
The Role of Crosstalk between AR3 and E2F1 in Drug Resistance in Prostate Cancer Cells. PMID:32354165
Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors. PMID:32352724
Gas6 expression is reduced in advanced breast cancers. PMID:32352034
BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression. PMID:32352029
Comparative proteogenomics profiling of non-small and small lung carcinoma cell lines using mass spectrometry. PMID:32351780
Erlotinib sensitivity of MAPK1p.D321N mutation in head and neck squamous cell carcinoma. PMID:32351709
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation. PMID:32350249
Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma: A Functional Assessment Based on Actin Three-Dimensional Structures. PMID:32349449
The F-box protein FBXL16 up-regulates the stability of C-MYC oncoprotein by antagonizing the activity of the F-box protein FBW7. PMID:32345600
Association Between Spatial Heterogeneity Within Nonmetastatic Gastroesophageal Adenocarcinomas and Survival. PMID:32338752
Identification of a metabolic gene panel to predict the prognosis of myelodysplastic syndrome. PMID:32337851
The Oncogenic Role of CENPA in Hepatocellular Carcinoma Development: Evidence from Bioinformatic Analysis. PMID:32337237
LRG1 May Accelerate the Progression of ccRCC via the TGF-β Pathway. PMID:32337221
Kinome multigenic panel identified novel druggable EPHB4-V871I somatic variant in high-risk neuroblastoma. PMID:32336043
Identification of METTL3 as an Adverse Prognostic Biomarker in Hepatocellular Carcinoma. PMID:32333311
HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity. PMID:32331382
Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors. PMID:32331249
Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy. PMID:32325691
Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis. PMID:32325032
Identification of lung adenocarcinoma biomarkers based on bioinformatic analysis and human samples. PMID:32323809
Targeting Rac and Cdc42 GEFs in Metastatic Cancer. PMID:32322580
High-throughput gene screen reveals modulators of nuclear shape. PMID:32320319
An Effective Graph Clustering Method to Identify Cancer Driver Modules. PMID:32318558
Robust Biomarker Screening Using Spares Learning Approach for Liver Cancer Prognosis. PMID:32318552
Pan-cancer Analysis of CDK12 Alterations Identifies a Subset of Prostate Cancers with Distinct Genomic and Clinical Characteristics. PMID:32317181
Prognostic significance of an invasive leader cell-derived mutation cluster on chromosome 16q. PMID:32315457
Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone. PMID:32314873
ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes. PMID:32313225
Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model. PMID:32313004
TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism. PMID:32312982
A novel 20-gene prognostic score in pancreatic adenocarcinoma. PMID:32310997
Long Non-Coding RNA LEF1-AS1 Promotes Migration, Invasion and Metastasis of Colon Cancer Cells Through miR-30-5p/SOX9 Axis. PMID:32308428
Overexpression of COL24A1 in Hepatocellular Carcinoma Predicts Poor Prognosis: A Study Based on Multiple Databases, Clinical Samples and Cell Lines. PMID:32308416
The SWI/SNF complex in cancer - biology, biomarkers and therapy. PMID:32303701
Plasma membrane expression of G protein-coupled estrogen receptor (GPER)/G protein-coupled receptor 30 (GPR30) is associated with worse outcome in metachronous contralateral breast cancer. PMID:32302351
A Five-Genes-Based Prognostic Signature for Cervical Cancer Overall Survival Prediction. PMID:32300605
CREB1 is affected by the microRNAs miR-22-3p, miR-26a-5p, miR-27a-3p, and miR-221-3p and correlates with adverse clinicopathological features in renal cell carcinoma. PMID:32300145
Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer. PMID:32300050
Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib. PMID:32297440
Comprehensive Analysis of AR Alterations in Circulating Tumor DNA from Patients with Advanced Prostate Cancer. PMID:32297439
Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer. PMID:32295144
Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington's Disease. PMID:32295075
Identification of CELSR2 as a novel prognostic biomarker for hepatocellular carcinoma. PMID:32293343
A negative storage model for precise but compact storage of genetic variation data. PMID:32293013
Mutational landscape and characteristics of ERBB2 in non-small cell lung cancer. PMID:32291971
Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. PMID:32289751
Re-definition of claudin-low as a breast cancer phenotype. PMID:32286297
MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling. PMID:32286266
Lymphovascular invasion in breast cancer is associated with gene expression signatures of cell proliferation but not lymphangiogenesis or immune response. PMID:32285241
The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma. PMID:32284793
Characterization of the prognostic values and response to immunotherapy/chemotherapy of Krüppel-like factors in prostate cancer. PMID:32281273
Transcriptomic Analysis of Glioma Based on IDH Status Identifies ACAA2 as a Prognostic Factor in Lower Grade Glioma. PMID:32280672
Peroxisome proliferator-activated receptor gamma as a theragnostic target for mesenchymal-type glioblastoma patients. PMID:32280134
A novel diagnostic system to evaluate epidermal growth factor receptor impact as a prognostic and therapeutic indicator for lung adenocarcinoma. PMID:32277151
High-Throughput Sequencing Identifies 3 Novel Susceptibility Genes for Hereditary Melanoma. PMID:32276436
The Receptor Tyrosine Kinase RON and Its Isoforms as Therapeutic Targets in Ewing Sarcoma. PMID:32272784
DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation. PMID:32264658
Evaluation of X-Ray Repair Cross-Complementing Family Members as Potential Biomarkers for Predicting Progression and Prognosis in Hepatocellular Carcinoma. PMID:32258128
On the Role of Artificial Intelligence in Genomics to Enhance Precision Medicine. PMID:32256101
STK11 mutation status is associated with decreased survival in meningiomas. PMID:32253637
Genomics of MPNST (GeM) Consortium: Rationale and Study Design for Multi-Omic Characterization of NF1-Associated and Sporadic MPNSTs. PMID:32252413
The pan-cancer landscape of netrin family reveals potential oncogenic biomarkers. PMID:32251318
CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation. PMID:32249801
Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells. PMID:32249776
The Mystery of Rap1 Suppression of Oncogenic Ras. PMID:32249186
Proteomic profiling of FBXW7-mutant serous endometrial cancer cells reveals upregulation of PADI2, a potential therapeutic target. PMID:32248654
Actionable Potentials of Less Frequently Mutated Genes in Colorectal Cancer and Their Roles in Precision Medicine. PMID:32245111
Recognition Dynamics of Cancer Mutations on the ERp57-Tapasin Interface. PMID:32244998
The Missing Lnc: The Potential of Targeting Triple-Negative Breast Cancer and Cancer Stem Cells by Inhibiting Long Non-Coding RNAs. PMID:32244924
SAMHD1 Functions and Human Diseases. PMID:32244340
KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer. PMID:32243837
Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts. PMID:32240795
A genomic and epigenomic atlas of prostate cancer in Asian populations. PMID:32238934
Meta-Analysis Based on Nonconvex Regularization. PMID:32238826
Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis. PMID:32238586
Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy. PMID:32238357
RNF43 mutation is associated with aggressive tumor biology along with BRAF V600E mutation in right-sided colorectal cancer. PMID:32236609
Development of a prognostic index and screening of potential biomarkers based on immunogenomic landscape analysis of colorectal cancer. PMID:32235004
LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma. PMID:32234847
Metastatic Melanoma Patient-Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition. PMID:32234759
Beyond repression of Nrf2: An update on Keap1. PMID:32234331
Controversies around the function of LARP1. PMID:32233986
Histone methyltransferase SETD2: a potential tumor suppressor in solid cancers. PMID:32231741
Landscape of BRIP1 molecular lesions in gastrointestinal cancers from published genomic studies. PMID:32231423
Bioinformatics Analysis of Prognostic Tumor Microenvironment-Related Genes in the Tumor Microenvironment of Hepatocellular Carcinoma. PMID:32231177
Vitamin D Suppresses Ovarian Cancer Growth and Invasion by Targeting Long Non-Coding RNA CCAT2. PMID:32230936
Extracellular Protease ADAMTS1 Is Required at Early Stages of Human Uveal Melanoma Development by Inducing Stemness and Endothelial-Like Features on Tumor Cells. PMID:32230715
A comprehensive analysis of IDO1 expression with tumour-infiltrating immune cells and mutation burden in gynaecologic and breast cancers. PMID:32227579
Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine. PMID:32226924
Upregulation of deubiquitinase PSMD14 in lung adenocarcinoma (LUAD) and its prognostic significance. PMID:32226511
Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation. PMID:32226312
Nucleotide binding domain and leucine-rich repeat pyrin domain-containing protein 12: characterization of its binding to hematopoietic cell kinase. PMID:32226298
Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2. PMID:32224897
Complete response to anti-PD-L1 antibody in a metastatic bladder cancer associated with novel MSH4 mutation and microsatellite instability. PMID:32221012
Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts. PMID:32220884
Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer. PMID:32219437
Transcription levels and prognostic significance of the NFI family members in human cancers. PMID:32219034
Intratumoral heterogeneity of glutaminase and lactate dehydrogenase A protein expression in colorectal cancer. PMID:32218849
VIRMA-Dependent N6-Methyladenosine Modifications Regulate the Expression of Long Non-Coding RNAs CCAT1 and CCAT2 in Prostate Cancer. PMID:32218194
Identification and validation of dichotomous immune subtypes based on intratumoral immune cells infiltration in clear cell renal cell carcinoma patients. PMID:32217761
High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC. PMID:32216563
Identification of prognostic long noncoding RNAs associated with spontaneous regression of neuroblastoma. PMID:32216054
Microbiome analyses of blood and tissues suggest cancer diagnostic approach. PMID:32214244
Coordination of mRNA and tRNA methylations by TRMT10A. PMID:32213595
Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis. PMID:32213586
RNF168-Mediated Ubiquitin Signaling Inhibits the Viability of BRCA1-Null Cancers. PMID:32213544
Cytokines secreted by stromal cells in TNBC microenvironment as potential targets for cancer therapy. PMID:32213106
Cellular processes involved in lung cancer cells exposed to direct current electric field. PMID:32210363
OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine. PMID:32210335
The Frequency of Ras Mutations in Cancer. PMID:32209560
Wild-Type IDH1 and Mutant IDH1 Opposingly Regulate Podoplanin Expression in Glioma. PMID:32208352
Recent Improvements in Genomic and Transcriptomic Understanding of Anaplastic and Poorly Differentiated Thyroid Cancers. PMID:32207263
Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer. PMID:32206093
Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis. PMID:32205868
Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. PMID:32205440
Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells. PMID:32203164
Comprehensive bioinformatic analysis of Wnt1 and Wnt1-associated diseases. PMID:32201670
CD148 Serves as a Prognostic Marker of Gastric Cancer and Hinders Tumor Progression by Dephosphorylating EGFR. PMID:32201537
Integrative Analysis of Siglec-15 mRNA in Human Cancers Based on Data Mining. PMID:32201516
Dissenting degradation: Deubiquitinases in cell cycle and cancer. PMID:32201366
Comparative genomic profiling of glandular bladder tumours. PMID:32198650
Dual regulation of p53 by the ribosome maturation factor SBDS. PMID:32198344
The tubal epigenome - An emerging target for ovarian cancer. PMID:32197795
Cancer Genetics and Therapeutic Opportunities in Urologic Practice. PMID:32197306
Immune and Stroma Related Genes in Breast Cancer: A Comprehensive Analysis of Tumor Microenvironment Based on the Cancer Genome Atlas (TCGA) Database. PMID:32195260
The HIPPO pathway in gynecological malignancies. PMID:32195031
FGD1 promotes tumor progression and regulates tumor immune response in osteosarcoma via inhibiting PTEN activity. PMID:32194840
Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma. PMID:32194798
FKBP4 is a malignant indicator in luminal A subtype of breast cancer. PMID:32194784
ZW10 interacting kinetochore protein may serve as a prognostic biomarker for human breast cancer: An integrated bioinformatics analysis. PMID:32194714
FBW7 in hematological tumors. PMID:32194657
Integrated analysis of gene expression and DNA methylation profiles in ovarian cancer. PMID:32192517
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome. PMID:32188943
Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies. PMID:32188707
Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer. PMID:32188493
Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma. PMID:32188490
Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis. PMID:32187176
Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. PMID:32184446
The Oncogenic Potential of the Centromeric Border Protein FAM84B of the 8q24.21 Gene Desert. PMID:32183428
ATM-Deficient Cancers Provide New Opportunities for Precision Oncology. PMID:32183301
The Role of Polycomb Repressive Complex in Malignant Peripheral Nerve Sheath Tumor. PMID:32182803
Identification of key genes and pathways of diagnosis and prognosis in cervical cancer by bioinformatics analysis. PMID:32181600
Identification of 13 Key Genes Correlated With Progression and Prognosis in Hepatocellular Carcinoma by Weighted Gene Co-expression Network Analysis. PMID:32180800
Gene Expression Alterations and Molecular Analysis of CHEK1 in Solid Tumors. PMID:32178478
Hormone Receptor-Positive/Human Epidermal Growth Receptor 2-Negative Metastatic Breast Cancer in Young Women: Emerging Data in the Era of Molecularly Targeted Agents. PMID:32176406
The construction and analysis of tumor-infiltrating immune cells and ceRNA networks in metastatic adrenal cortical carcinoma. PMID:32175564
Systematical Analysis of the Cancer Genome Atlas Database Reveals EMCN/MUC15 Combination as a Prognostic Signature for Gastric Cancer. PMID:32175327
FBXW4 Is Highly Expressed and Associated With Poor Survival in Acute Myeloid Leukemia. PMID:32175272
Gene mutations distinguishing gastric from colorectal and esophageal adenocarcinomas. PMID:32175104
Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma. PMID:32169869
SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism. PMID:32166001
Tumor mutational burden is associated with poor outcomes in diffuse glioma. PMID:32164609
Identification of potential novel biomarkers to differentiate malignant thyroid nodules with cytological indeterminate. PMID:32164602
Metagenomic characterization of lysine acetyltransferases in human cancer and their association with clinicopathologic features. PMID:32162442
Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors. PMID:32161105
Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma. PMID:32158696
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways. PMID:32156008
Integrated analysis of gene expression, alteration and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer. PMID:32154045
Targeting Chromosomal Architectural HMGB Proteins Could Be the Next Frontier in Cancer Therapy. PMID:32152151
Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer. PMID:32150102
CancerLivER: a database of liver cancer gene expression resources and biomarkers. PMID:32147717
NBIA: a network-based integrative analysis framework - applied to pathway analysis. PMID:32144346
Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain. PMID:32143622
Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer. PMID:32142667
OncoMX: A Knowledgebase for Exploring Cancer Biomarkers in the Context of Related Cancer and Healthy Data. PMID:32142370
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy. PMID:32139506
PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models. PMID:32139402
Non-Thermal Plasma Induces Antileukemic Effect Through mTOR Ubiquitination. PMID:32131492
Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. PMID:32128997
Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer. PMID:32127696
HDMAC: A Web-Based Interactive Program for High-Dimensional Analysis of Molecular Alterations in Cancer. PMID:32127576
Muscleblind-like 2 controls the hypoxia response of cancer cells. PMID:32127384
CDK1 and CDC20 overexpression in patients with colorectal cancer are associated with poor prognosis: evidence from integrated bioinformatics analysis. PMID:32127012
Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis. PMID:32123305
Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells. PMID:32123273
Mutations in the coat complex II component SEC23B promote colorectal cancer metastasis. PMID:32123160
A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets. PMID:32123069
Prioritizing Gene Cascading Paths to Model Colorectal Cancer Through Engineered Organoids. PMID:32117908
Comprehensive Review of Web Servers and Bioinformatics Tools for Cancer Prognosis Analysis. PMID:32117725
Germ Cell-Specific Gene 1-Like Protein Regulated by Splicing Factor CUGBP Elav-Like Family Member 5 and Primary Bile Acid Biosynthesis are Prognostic in Glioblastoma Multiforme. PMID:32117422
Programmed death-ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21-gene and 70-gene signatures in estrogen receptor-positive disease. PMID:32115850
XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary. PMID:32115573
Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells. PMID:32112300
FKBP9 promotes the malignant behavior of glioblastoma cells and confers resistance to endoplasmic reticulum stress inducers. PMID:32111229
Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover. PMID:32106628
Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma. PMID:32104684
Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer. PMID:32103870
Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3. PMID:32102440
Identification of Potential Prognostic Long Non-Coding RNA Biomarkers for Predicting Recurrence in Patients with Cervical Cancer. PMID:32099468
Strategies for Increasing the Effectiveness of Aromatase Inhibitors in Locally Advanced Breast Cancer: An Evidence-Based Review on Current Options. PMID:32099464
Small Molecule Binds with Lymphocyte Antigen 6K to Induce Cancer Cell Death. PMID:32098321
A transcriptional co-expression network-based approach to identify prognostic biomarkers in gastric carcinoma. PMID:32095347
A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma. PMID:32093809
Increased Expression of Micro-RNA-23a Mediates Chemoresistance to Cytarabine in Acute Myeloid Leukemia. PMID:32093419
Identification of Genes Associated with the Metastasis of Pheochromocytoma/Paraganglioma Based on Weighted Gene Coexpression Network Analysis. PMID:32090084
Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers. PMID:32087759
Transcriptome Analysis Identifies ALCAM Overexpression as a Prognosis Biomarker in Laryngeal Squamous Cell Carcinoma. PMID:32085563
Risk score based on expression of five novel genes predicts survival in soft tissue sarcoma. PMID:32084007
Genetic alterations of malignant pleural mesothelioma: association with tumor heterogeneity and overall survival. PMID:32083805
Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma. PMID:32083006
PVT1 Long Non-coding RNA in Gastrointestinal Cancer. PMID:32083000
Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer. PMID:32080887
The clinical and prognostic significance of FOXN3 downregulation in acute myeloid leukaemia. PMID:32078244
Effects of MIR143 on rat sarcoma signaling networks in solid tumors: A brief overview. PMID:32077199
Multi-omics Data Integration, Interpretation, and Its Application. PMID:32076369
Dickkopf-2 (DKK2) as Context Dependent Factor in Patients with Esophageal Adenocarcinoma. PMID:32075129
Epigenetics of SFRP1: The Dual Roles in Human Cancers. PMID:32074995
Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy. PMID:32074012
Fallopian tube initiation of high grade serous ovarian cancer and ovarian metastasis: Mechanisms and therapeutic implications. PMID:32067992
Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis. PMID:32067422
Homologous recombination deficiency status-based classification of high-grade serous ovarian carcinoma. PMID:32066851
DNA repair gene expression is associated with differential prognosis between HPV16 and HPV18 positive cervical cancer patients following radiation therapy. PMID:32066835
Machine Learning and Bioinformatics Models to Identify Pathways that Mediate Influences of Welding Fumes on Cancer Progression. PMID:32066756
A role for caveola-forming proteins caveolin-1 and CAVIN1 in the pro-invasive response of glioblastoma to osmotic and hydrostatic pressure. PMID:32065471
Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery. PMID:32064048
Ubiquitin-specific peptide 22 acts as an oncogene in gastric cancer in a son of sevenless 1-dependent manner. PMID:32063746
Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer. PMID:32061630
Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers. PMID:32059806
The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis. PMID:32057095
Detection of pancreatic ductal adenocarcinoma with galectin-9 serum levels. PMID:32055023
LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance. PMID:32054769
Mechanical regulation of glycolysis via cytoskeleton architecture. PMID:32051585
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically. PMID:32051553
Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal. PMID:32050609
Screening and Identification of Key Biomarkers for Bladder Cancer: A Study Based on TCGA and GEO Data. PMID:32047816
RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice. PMID:32047266
Development and validation of a novel immune-related prognostic model in hepatocellular carcinoma. PMID:32046766
Separated Siamese Twins: Intronic Small Nucleolar RNAs and Matched Host Genes May be Altered in Conjunction or Separately in Multiple Cancer Types. PMID:32046192
Novel ESCC-related gene ZNF750 as potential Prognostic biomarker and inhibits Epithelial-Mesenchymal Transition through directly depressing SNAI1 promoter in ESCC. PMID:32042337
Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts. PMID:32042320
Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling. PMID:32042113
The role of RICTOR amplification in targeted therapy and drug resistance. PMID:32041519
Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night. PMID:32041394
Gene Expression Signature Predictive of Neuroendocrine Transformation in Prostate Adenocarcinoma. PMID:32041153
Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae. PMID:32041123
APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. PMID:32037952
MET targeting: time for a rematch. PMID:32034310
Cyclin-Dependent Kinase and Antioxidant Gene Expression in Cancers with Poor Therapeutic Response. PMID:32033319
Synergy between Non-Thermal Plasma with Radiation Therapy and Olaparib in a Panel of Breast Cancer Cell Lines. PMID:32033118
Identifying multi-hit carcinogenic gene combinations: Scaling up a weighted set cover algorithm using compressed binary matrix representation on a GPU. PMID:32029803
Individual-patient prediction of meningioma malignancy and survival using the Surveillance, Epidemiology, and End Results database. PMID:32025573
Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model. PMID:32025000
Biologically Aggressive Phenotype and Anti-cancer Immunity Counterbalance in Breast Cancer with High Mutation Rate. PMID:32024876
Molecular profiling identifies synchronous endometrial and ovarian cancers as metastatic endometrial cancer with favorable clinical outcome. PMID:32022266
Oncogene-dependent function of BRG1 in hepatocarcinogenesis. PMID:32019910
Probing the mutational landscape of regulators of G protein signaling proteins in cancer. PMID:32019900
Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches. PMID:32019869
Integrative analysis of highly mutated genes in hepatitis B virus-related hepatic carcinoma. PMID:32017470
Identification of cancer driver genes based on nucleotide context. PMID:32015527
Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer. PMID:32015486
Synthetic Lethal Targeting of Mitotic Checkpoints in HPV-Negative Head and Neck Cancer. PMID:32012873
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer. PMID:32012149
Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics. PMID:32010623
Genomic Features and Clinical Characteristics of Adolescents and Young Adults With Cholangiocarcinoma. PMID:32010606
Cyclin D1 expression as a potential prognostic factor in advanced KRAS-mutant non-small cell lung cancer. PMID:32010574
Comparative expression analysis in small cell lung carcinoma reveals neuroendocrine pattern change in primary tumor versus lymph node metastases. PMID:32010572
Grainyhead-like transcription factors in cancer - Focus on recent developments. PMID:32008358
Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone. PMID:32007910
Comprehensive analysis of inhibitor of differentiation/DNA-binding gene family in lung cancer using bioinformatics methods. PMID:32003423
Clinical characteristics of malignant melanoma in central China and predictors of metastasis. PMID:32002034
Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients. PMID:32000721
Bioinformatics-Based Discovery of CKLF-Like MARVEL Transmembrane Member 5 as a Novel Biomarker for Breast Cancer. PMID:31998718
Phase II Trial of Cabozantinib in Recurrent/Metastatic Endometrial Cancer: A Study of the Princess Margaret, Chicago, and California Consortia (NCI9322/PHL86). PMID:31992589
Evidence-Based Network Approach to Recommending Targeted Cancer Therapies. PMID:31990579
Carcinogenesis effects of E2F transcription factor 8 (E2F8) in hepatocellular carcinoma outcomes: an integrated bioinformatic report. PMID:31990034
PIK3CA gene aberrancy and role in targeted therapy of solid malignancies. PMID:31988478
Low-frequency TP53 hotspot mutation contributes to chemoresistance through clonal expansion in acute myeloid leukemia. PMID:31988438
Machine Learning and Network Analyses Reveal Disease Subtypes of Pancreatic Cancer and their Molecular Characteristics. PMID:31988390
Lipid desaturation-associated endoplasmic reticulum stress regulates MYCN gene expression in hepatocellular carcinoma cells. PMID:31988297
Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28. PMID:31982308
Mesothelioma: Hippo pathway as a target, lessons from COMMAND. PMID:31976036
Replisome genes regulation by antitumor miR-101-5p in clear cell renal cell carcinoma. PMID:31975570
Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing. PMID:31974171
A Multi-Omics Analysis of Bone Morphogenetic Protein 5 (BMP5) mRNA Expression and Clinical Prognostic Outcomes in Different Cancers Using Bioinformatics Approaches. PMID:31973134
Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia. PMID:31971569
Genetic alterations of interleukin-17 and related genes in human prostate cancer. PMID:31970232
IDH1-R132H mutation radiosensitizes U87MG glioma cells via epigenetic downregulation of TIGAR. PMID:31966064
Downregulation of LINC01140 is associated with adverse features of breast cancer. PMID:31966045
Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis. PMID:31964905
A qualitative transcriptional signature for predicting the biochemical recurrence risk of prostate cancer patients after radical prostatectomy. PMID:31961962
HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair. PMID:31960047
Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers. PMID:31959902
Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity. PMID:31959836
Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression. PMID:31957540
Germline mutations of SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type and in SMARCA4-deficient undifferentiated uterine sarcoma: Clinical features of a single family and comparison of large cohorts. PMID:31954538
Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes. PMID:31953484
Single-molecule detection of cancer mutations using a novel PCR-LDR-qPCR assay. PMID:31950578
Clinical relevance of somatic mutations in main driver genes detected in gastric cancer patients by next-generation DNA sequencing. PMID:31949278
Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis. PMID:31949145
Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment. PMID:31944090
Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer. PMID:31942683
MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer. PMID:31942031
FOXD3 Regulates VISTA Expression in Melanoma. PMID:31940493
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. PMID:31940491
Clinical implication of UCA1 in non-small cell lung cancer and its effect on caspase-3/7 activation and apoptosis induction in vitro. PMID:31938341
Cell adhesion in cancer: Beyond the migration of single cells. PMID:31937589
Sorafenib Inhibits Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in Hepatocellular Carcinoma Cells. PMID:31936661
Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis. PMID:31935372
Prognostic value of epithelial-mesenchymal transition related genes: SLUG and QKI in breast cancer patients. PMID:31934023
The clinical significance of CHEK1 in breast cancer: a high-throughput data analysis and immunohistochemical study. PMID:31933717
C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts. PMID:31931851
Trametinib Activity in Patients with Solid Tumors and Lymphomas Harboring BRAF Non-V600 Mutations or Fusions: Results from NCI-MATCH (EAY131). PMID:31924734
Emerging Functions of Human IFIT Proteins in Cancer. PMID:31921891
Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4. PMID:31921386
TRIP13 regulates DNA repair pathway choice through REV7 conformational change. PMID:31915374
Generating Stable Knockout Zebrafish Lines by Deleting Large Chromosomal Fragments Using Multiple gRNAs. PMID:31915253
Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance. PMID:31914141
Integrative network analysis identifies cell-specific trans regulators of m6A. PMID:31912146
The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors. PMID:31911857
Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR-Mutant Lung Cancer. PMID:31911548
Omics-based integrated analysis identified ATRX as a biomarker associated with glioma diagnosis and prognosis. PMID:31908895
Amyloid Beta (A4) Precursor Protein: A Potential Biomarker for Recurrent Nasopharyngeal Carcinoma. PMID:31908537
Genetic analysis of pleomorphic and florid lobular carcinoma in situ variants: frequent ERBB2/ERBB3 alterations and clonal relationship to classic lobular carcinoma in situ and invasive lobular carcinoma. PMID:31907376
High MYC mRNA Expression Is More Clinically Relevant than MYC DNA Amplification in Triple-Negative Breast Cancer. PMID:31905596
SIRPB1 promotes prostate cancer cell proliferation via Akt activation. PMID:31905248
The prognostic value of tumor mutation burden in EGFR-mutant advanced lung adenocarcinoma, an analysis based on cBioPortal data base. PMID:31903239
Multi-cancer V-ATPase molecular signatures: A distinctive balance of subunit C isoforms in esophageal carcinoma. PMID:31901859
Aberrant Epidermal Growth Factor Receptor RNA Splice Products Are Among the Most Frequent Somatic Alterations in Clear Cell Renal Cell Carcinoma and Are Associated with a Poor Response to Immunotherapy. PMID:31901438
Retained or altered expression of major histocompatibility complex class I in patient-derived xenograft models in breast cancer. PMID:31900802
Spitz melanoma is a distinct subset of spitzoid melanoma. PMID:31900433
A regulatory role for CHD2 in myelopoiesis. PMID:31900031
TRPV6 as A Target for Cancer Therapy. PMID:31897233
Bioinformatics analysis of the expression of HOXC13 and its role in the prognosis of breast cancer. PMID:31897205
POLR1B is upregulated and promotes cell proliferation in non-small cell lung cancer. PMID:31897183
Genome-wide analysis reveals the emerging roles of long non-coding RNAs in cancer. PMID:31897174
FNDC3B is associated with ER stress and poor prognosis in cervical cancer. PMID:31897153
BATF acts as an oncogene in non-small cell lung cancer. PMID:31897131
ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity. PMID:31895940
Short-Term Environmental Conditioning Enhances Tumorigenic Potential of Triple-Negative Breast Cancer Cells. PMID:31893233
High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation. PMID:31892360
Comprehensive analysis of DNA methylation and gene expression profiles in cholangiocarcinoma. PMID:31889904
Structure and regulation of human epithelial cell transforming 2 protein. PMID:31888991
Discovering Rare Genes Contributing to Cancer Stemness and Invasive Potential by GBM Single-Cell Transcriptional Analysis. PMID:31888172
Insulin-Like Growth Factor Binding Protein 5-A Probable Target of Kidney Renal Papillary Renal Cell Carcinoma. PMID:31886201
The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer. PMID:31880305
Genetic links between endometriosis and cancers in women. PMID:31879572
Single Nucleotide Polymorphism rs6942067 Is a Risk Factor in Young and in Non-Smoking Patients with HPV Negative Head and Neck Squamous Cell Carcinoma. PMID:31878157
Genomics of lethal prostate cancer at diagnosis and castration resistance. PMID:31874108
Fluorouracil sensitivity in a head and neck squamous cell carcinoma with a somatic DPYD structural variant. PMID:31871216
Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity. PMID:31869219
SMAD4 Somatic Mutations in Head and Neck Carcinoma Are Associated With Tumor Progression. PMID:31867281
The Thyroid Hormone Receptor-RUNX2 Axis: A Novel Tumor Suppressive Pathway in Breast Cancer. PMID:31865591
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth. PMID:31863007
Reactive Oxygen Species Drive Proliferation in Acute Myeloid Leukemia via the Glycolytic Regulator PFKFB3. PMID:31862780
Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma. PMID:31862696
Modulation of proliferation factors in lung adenocarcinoma with an analysis of the transcriptional consequences of genomic EGFR activation. PMID:31857847
Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer. PMID:31852841
Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma. PMID:31852831
Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition. PMID:31852795
Screening, identification and validation of CCND1 and PECAM1/CD31 for predicting prognosis in renal cell carcinoma patients. PMID:31850854
Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer. PMID:31849319
RHPCG: a database of the Regulation of the Hippo Pathway in Cancer Genome. PMID:31848596
ERK1 indicates good prognosis and inhibits breast cancer progression by suppressing YAP1 signaling. PMID:31848326
FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1. PMID:31846430
Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer. PMID:31844668
Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer. PMID:31842906
Preoperative plasma fatty acid metabolites inform risk of prostate cancer progression and may be used for personalized patient stratification. PMID:31842810
A systematic analysis of immune genes and overall survival in cancer patients. PMID:31842801
Temporal VEGFA responsive genes in HUVECs: Gene signatures and potential ligands/receptors fine-tuning angiogenesis. PMID:31840205
Systematic expression analysis of WEE family kinases reveals the importance of PKMYT1 in breast carcinogenesis. PMID:31837068
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas. PMID:31836708
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy. PMID:31836706
Prostate-Derived ETS Factor (PDEF) Modulates Yes Associated Protein 1 (YAP1) in Prostate Cancer Cells: A Potential Cross-Talk between PDEF and Hippo Signaling. PMID:31835563
Harmonization of Tumor Mutational Burden Quantification and Association With Response to Immune Checkpoint Blockade in Non-Small-Cell Lung Cancer. PMID:31832578
Dickkopf-related protein 1, a new biomarker for local immune status and poor prognosis among patients with colorectal liver Oligometastases: a retrospective study. PMID:31830954
Long Noncoding RNA PTTG3P Expression Is an Unfavorable Prognostic Marker for Patients With Hepatocellular Carcinoma. PMID:31829099
Integrative Analysis Reveals Comprehensive Altered Metabolic Genes Linking with Tumor Epigenetics Modification in Pan-Cancer. PMID:31828117
Clinical significance of stromal ER and PR expression in periampullary adenocarcinoma. PMID:31827798
NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis. PMID:31827722
MAP2K1 is a potential therapeutic target in erlotinib resistant head and neck squamous cell carcinoma. PMID:31827134
Alterations of the interactome of Bcl-2 proteins in breast cancer at the transcriptional, mutational and structural level. PMID:31825969
A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. PMID:31825826
NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma. PMID:31824170
Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer. PMID:31822799
Transient receptor potential cation channel subfamily V and breast cancer. PMID:31822791
PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization. PMID:31822657
Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer. PMID:31822495
Prognostic value of immune-related genes in clear cell renal cell carcinoma. PMID:31821170
High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer. PMID:31819188
Increased inflammatory lipid metabolism and anaplerotic mitochondrial activation follow acquired resistance to vemurafenib in BRAF-mutant melanoma cells. PMID:31819183
Aberrant activation of hepatocyte growth factor/MET signaling promotes β-catenin-mediated prostatic tumorigenesis. PMID:31819003
RASSF10 Is a TGFβ-Target That Regulates ASPP2 and E-Cadherin Expression and Acts as Tumor Suppressor That Is Epigenetically Downregulated in Advanced Cancer. PMID:31817988
Newly Developed CK1-Specific Inhibitors Show Specifically Stronger Effects on CK1 Mutants and Colon Cancer Cell Lines. PMID:31817920
Pannexin1 Is Associated with Enhanced Epithelial-To-Mesenchymal Transition in Human Patient Breast Cancer Tissues and in Breast Cancer Cell Lines. PMID:31817827
TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-κB Signaling Cascade. PMID:31817720
Collagen prolyl 4-hydroxylase 2 predicts worse prognosis and promotes glycolysis in cervical cancer. PMID:31814898
Identification of potential core genes in metastatic renal cell carcinoma using bioinformatics analysis. PMID:31814889
Development and preclinical pharmacology of a novel dCK inhibitor, DI-87. PMID:31812677
The most common RNF43 mutant G659Vfs*41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis. PMID:31811196
Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress. PMID:31809739
Bioinformatics Analysis of Expression and Alterations of BARD1 in Breast Cancer. PMID:31808361
Reduced expression of microRNA-139-5p in hepatocellular carcinoma results in a poor outcome: An exploration the roles of microRNA-139-5p in tumorigenesis, advancement and prognosis at the molecular biological level using an integrated meta-analysis and bioinformatic investigation. PMID:31807180
Identification of key candidate