FAIRsharing.6L6MjA; Last edited: Jan. 9, 2019, 3:06 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

Other names: cBioPortal

The cBioPortal for Cancer Genomics provides visualization, analysis and download of large-scale cancer genomics data sets.

Webpage:

http://www.cbioportal.org

Licence:

Name: GNU Affero General Public License
URL: http://www.gnu.org/licenses/agpl-3.0.html

Publications:

Publications
More detailed information about this field from each metasource.

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
PMID: 22588877
metasource: Fairsharing.org
version: FAIRsharing.org: cBioPortal; cBioPortal for Cancer Genomics; DOI: https://doi.org/10.25504/FAIRsharing.6L6MjA; Last edited: Jan. 9, 2019, 3:06 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
PMID: 23550210
metasource: Fairsharing.org
version: FAIRsharing.org: cBioPortal; cBioPortal for Cancer Genomics; DOI: https://doi.org/10.25504/FAIRsharing.6L6MjA; Last edited: Jan. 9, 2019, 3:06 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

http://dx.doi.org/10.1126/scisignal.2004088
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data PubMed citations: 6909.

6909 articles citing: The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

BCHE as a Prognostic Biomarker in Endometrial Cancer and Its Correlation with Immunity. PMID:35915658
Comprehensive Pan-Cancer Analysis of Senescence With Cancer Prognosis and Immunotherapy. PMID:35911954
Prognostic impact of PDGFRA gain/amplification and MGMT promoter methylation status in patients with IDH wild-type glioblastoma. PMID:35911637
Molecular Landscape of ERBB2 Alterations in 14,956 Solid Tumors. PMID:35911441
High expression of ZFP36L2 correlates with the prognosis and immune infiltration in lower-grade glioma. PMID:35910229
A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML. PMID:35906694
Proteotranscriptomics of ocular adnexal B-cell lymphoma reveals an oncogenic role of alternative splicing and identifies a diagnostic marker. PMID:35906682
Deoxythymidylate Kinase as a Promising Marker for Predicting Prognosis and Immune Cell Infiltration of Pan-cancer. PMID:35903153
Mutant p53 drives an immune cold tumor immune microenvironment in oral squamous cell carcinoma. PMID:35902768
Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes. PMID:35902588
The hexokinase "HKDC1" interaction with the mitochondria is essential for liver cancer progression. PMID:35902556
JMJD8 Is an M2 Macrophage Biomarker, and It Associates With DNA Damage Repair to Facilitate Stemness Maintenance, Chemoresistance, and Immunosuppression in Pan-Cancer. PMID:35898493
Analysis of the Effect of SNAI Family in Breast Cancer and Immune Cell. PMID:35898399
GRHL2 Expression Functions in Breast Cancer Aggressiveness and Could Serve as Prognostic and Diagnostic Biomarker for Breast Cancer. PMID:35898391
Genomic Predictors of Recurrence Patterns After Complete Resection of Colorectal Liver Metastases and Adjuvant Hepatic Artery Infusion Chemotherapy. PMID:35896920
Pan-Cancer Analysis Reveals the Prognostic Potential of the THAP9/THAP9-AS1 Sense-Antisense Gene Pair in Human Cancers. PMID:35893234
The Identification by Exome Sequencing of Candidate Genes in BRCA-Negative Tunisian Patients at a High Risk of Hereditary Breast/Ovarian Cancer. PMID:35893033
FXYD3 Expression Predicts Poor Prognosis in Renal Cell Carcinoma with Immunosuppressive Tumor Microenvironment. PMID:35892856
Identification of Malignant Cell Populations Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer Using Single-Cell RNA Sequencing. PMID:35892844
AKT1 Transcriptomic Landscape in Breast Cancer Cells. PMID:35892586
Breast Cancer during Pregnancy as a Special Type of Early-Onset Breast Cancer: Analysis of the Tumor Immune Microenvironment and Risk Profiles. PMID:35892583
Biomarkers Regulated by Lipid-Soluble Vitamins in Glioblastoma. PMID:35889829
Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases. PMID:35887358
Integrated Workflow for the Label-Free Isolation and Genomic Analysis of Single Circulating Tumor Cells in Pancreatic Cancer. PMID:35887203
Efficient Identification of the MYC Regulator with the Use of the CRISPR Library and Context-Matched Database Screenings. PMID:35887071
Identification of Antitumor miR-30e-5p Controlled Genes; Diagnostic and Prognostic Biomarkers for Head and Neck Squamous Cell Carcinoma. PMID:35886008
Oleocanthal Attenuates Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence by Targeting SMYD2. PMID:35884603
The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth. PMID:35884550
Genomic Landscape, Clinical Features and Outcomes of Non-Small Cell Lung Cancer Patients Harboring BRAF Alterations of Distinct Functional Classes. PMID:35884534
Targeted Next-Generation Sequencing of Thymic Epithelial Tumours Revealed Pathogenic Variants in KIT, ERBB2, KRAS, and TP53 in 30% of Thymic Carcinomas. PMID:35884448
Focal Adhesion Kinase Provides a Collateral Vulnerability That Can Be Leveraged to Improve mTORC1 Inhibitor Efficacy. PMID:35884439
PRIM2 Promotes Cell Cycle and Tumor Progression in p53-Mutant Lung Cancer. PMID:35884433
Homo and Heterotypic Cellular Cross-Talk in Epithelial Ovarian Cancer Impart Pro-Tumorigenic Properties through Differential Activation of the Notch3 Pathway. PMID:35884426
Interleukin-11: A Potential Biomarker and Molecular Therapeutic Target in Non-Small Cell Lung Cancer. PMID:35883698
Landscape of genetic variants in sporadic meningiomas captured with clinical genomics. PMID:35881312
Oncogene addiction to GNAS in GNASR201 mutant tumors. PMID:35879396
The Aminoacyl-tRNA Synthetase and tRNA Expression Levels Are Deregulated in Cancer and Correlate Independently with Patient Survival. PMID:35877431
Using AI-Based Evolutionary Algorithms to Elucidate Adult Brain Tumor (Glioma) Etiology Associated with IDH1 for Therapeutic Target Identification. PMID:35877430
Deciphering Prognostic Value of TTN and Its Correlation With Immune Infiltration in Lung Adenocarcinoma. PMID:35875159
P-Rex1 Signaling Hub in Lower Grade Glioma Patients, Found by In Silico Data Mining, Correlates With Reduced Survival and Augmented Immune Tumor Microenvironment. PMID:35875157
The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma. PMID:35875075
Comprehensive Analyses of Immune Subtypes of Stomach Adenocarcinoma for mRNA Vaccination. PMID:35874675
Identifying an Immune-Related Gene ST8SIA1 as a Novel Target in Patients With Clear-Cell Renal Cell Carcinoma. PMID:35873547
Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer Analysis. PMID:35873470
Discovering the drivers of clonal hematopoiesis. PMID:35871184
Landscape of somatic alterations in large-scale solid tumors from an Asian population. PMID:35871175
A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer. PMID:35869079
Growth hormone receptor antagonism downregulates ATP-binding cassette transporters contributing to improved drug efficacy against melanoma and hepatocarcinoma in vivo. PMID:35865483
The Hippo Pathway Effector Transcriptional Co-activator With PDZ-Binding Motif Correlates With Clinical Prognosis and Immune Infiltration in Colorectal Cancer. PMID:35865173
Data driven and biophysical insights into the regulation of trafficking vesicles by extracellular matrix stiffness. PMID:35865140
PRMT5 acts as a tumor suppressor by inhibiting Wnt/β-catenin signaling in murine gastric tumorigenesis. PMID:35864961
PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib. PMID:35864202
HIF1α: A Novel Biomarker with Potential Prognostic and Immunotherapy in Pan-cancer. PMID:35860430
Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. PMID:35858357
Tumor antigens and immune subtypes of glioblastoma: the fundamentals of mRNA vaccine and individualized immunotherapy development. PMID:35855914
Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers. PMID:35853939
The splicing factor SF3B4 drives proliferation and invasion in cervical cancer by regulating SPAG5. PMID:35853859
Identification of a Prognostic Transcriptome Signature for Hepatocellular Carcinoma with Lymph Node Metastasis. PMID:35847584
Identification of Potential Antigens for Developing mRNA Vaccine for Immunologically Cold Mesothelioma. PMID:35846349
Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer. PMID:35846126
Expression and Prognostic Role of Glia Maturation Factor-γ in Gliomas. PMID:35845613
Comprehensive Computational Analysis of Honokiol Targets for Cell Cycle Inhibition and Immunotherapy in Metastatic Breast Cancer Stem Cells. PMID:35845599
The TTYH3/MK5 Positive Feedback Loop regulates Tumor Progression via GSK3-β/β-catenin signaling in HCC. PMID:35844789
DCBLD1 Overexpression Is Associated With a Poor Prognosis in Head and Neck Squamous Cell Carcinoma. PMID:35844572
Loss-of-function of the hippo transducer TAZ reduces mammary tumor growth through a myeloid-derived suppressor cell-dependent mechanism. PMID:35840667
Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis. PMID:35840569
Alterations in Somatic Driver Genes Are Associated with Response to Neoadjuvant FOLFIRINOX in Patients with Localized Pancreatic Ductal Adenocarcinoma. PMID:35839413
MUC1 expressing tumor growth was retarded after human mucin 1 (MUC1) plasmid DNA immunization. PMID:35839304
Overexpression of LIMA1 Indicates Poor Prognosis and Promotes Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma. PMID:35837368
Decoding signal transducer and activator of transcription 1 across various cancers through data mining and integrative analysis. PMID:35836889
Screening a novel six critical gene-based system of diagnostic and prognostic biomarkers in prostate adenocarcinoma patients with different clinical variables. PMID:35836886
Overexpressed SNRPB/D1/D3/E/F/G correlate with poor survival and immune infiltration in hepatocellular carcinoma. PMID:35836882
MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms. PMID:35821197
PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance. PMID:35820706
Downregulation of PGM5 expression correlates with tumor progression and poor prognosis in human prostate cancer. PMID:35819729
Identification of mRNA vaccines and conserved ferroptosis related immune landscape for individual precision treatment in bladder cancer. PMID:35818395
Genomic instability genes in lung and colon adenocarcinoma indicate organ specificity of transcriptomic impact on Copy Number Alterations. PMID:35817785
Gallic acid induces T-helper-1-like Treg cells and strengthens immune checkpoint blockade efficacy. PMID:35817479
Extra Spindle Pole Bodies-Like 1 Serves as a Prognostic Biomarker and Promotes Lung Adenocarcinoma Metastasis. PMID:35814478
Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer. PMID:35814476
S645C Point Mutation Suppresses Degradation of EGFR to Promote Progression of Glioblastoma. PMID:35814475
Identification of Novel Tumor Antigens and the Immune Landscapes of Bladder Cancer Patients for mRNA Vaccine Development. PMID:35814377
TRPs in Ovarian Serous Cystadenocarcinoma: The Expression Patterns, Prognostic Roles, and Potential Therapeutic Targets. PMID:35813831
Uterine Sarcoma Presenting as Hypercapnic Respiratory Failure. PMID:35813696
High SLC20A1 Expression Is Associated With Poor Prognosis for Radiotherapy of Estrogen Receptor-positive Breast Cancer. PMID:35813014
The Role of P4HA1 in Multiple Cancer Types and its Potential as a Target in Renal Cell Carcinoma. PMID:35812752
The clinical relevance of unfolded protein response signaling in breast cancer. PMID:35812054
Genetic variation associated with condensate dysregulation in disease. PMID:35809564
Identification of growth hormone receptor as a relevant target for precision medicine in low-EGFR expressing glioblastoma. PMID:35808822
Prognostic Ability of Enhancer RNAs in Metastasis of Non-Small Cell Lung Cancer. PMID:35807355
Prognostic Significance of HMGA1 Expression in Lung Cancer Based on Bioinformatics Analysis. PMID:35805937
Aldehyde Dehydrogenase 1B1 Is Implicated in DNA Damage Response in Human Colorectal Adenocarcinoma. PMID:35805102
High Expression of PRNP Predicts Poor Prognosis in Korean Patients with Gastric Cancer. PMID:35804944
Theranostic Potentials of Gold Nanomaterials in Hematological Malignancies. PMID:35804818
Therapy-related clonal cytopenia as a precursor to therapy-related myeloid neoplasms. PMID:35803921
The role of toll-like receptors (TLRs) in pan-cancer. PMID:35801728
Patients deriving long-term benefit from immune checkpoint inhibitors demonstrate conserved patterns of site-specific mutations. PMID:35798829
CPDR: An R Package of Recommending Personalized Drugs for Cancer Patients by Reversing the Individual's Disease-Related Signature. PMID:35795573
SEMA4D/PlexinB1 promotes AML progression via activation of PI3K/Akt signaling. PMID:35794581
Molecular dissection of a hyper-aggressive CBFB-MYH11/FLT3-ITD-positive acute myeloid leukemia. PMID:35794567
Syringin exerts anti-breast cancer effects through PI3K-AKT and EGFR-RAS-RAF pathways. PMID:35794555
Intratumoral PDGFB gene predominantly expressed in endothelial cells is associated with angiogenesis and lymphangiogenesis, but not with metastasis in breast cancer. PMID:35793004
A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic Targets. PMID:35791393
Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. PMID:35788181
SEMA3C Supports Pancreatic Cancer Progression by Regulating the Autophagy Process and Tumor Immune Microenvironment. PMID:35785187
A Comprehensive Pan-Cancer Analysis of the Tumorigenic Role of Matrix Metallopeptidase 7 (MMP7) Across Human Cancers. PMID:35785154
Activation Versus Inhibition of IGF1R: A Dual Role in Breast Tumorigenesis. PMID:35784559
ECM1 is associated with endocrine resistance in ER+ breast cancers. PMID:35784388
Lighting a Fire: Gasdermin-Mediated Pyroptosis Remodels the Glioma Microenvironment and Promotes Immune Checkpoint Blockade Response. PMID:35784306
Genomic Landscape of Metastatic Lymph Nodes and Primary Tumors in Non-Small-Cell Lung Cancer. PMID:35783357
RecQ Helicase Somatic Alterations in Cancer. PMID:35782872
Identification of SHCBP1 as a potential biomarker involving diagnosis, prognosis, and tumor immune microenvironment across multiple cancers. PMID:35782736
TumorDecon: A digital cytometry software. PMID:35782394
Clinical, histopathological, and molecular features of IDH-wildtype indolent diffuse glioma: comparison with typical glioblastoma. PMID:35779193
Correlation of changes in subclonal architecture with progression in the MMRF CoMMpass study. PMID:35777247
ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform. PMID:35776213
Identification of Hub Genes for Early Diagnosis and Predicting Prognosis in Colon Adenocarcinoma. PMID:35774271
Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy. PMID:35773527
Disassembly of α6β4-mediated hemidesmosomal adhesions promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin to focal adhesions. PMID:35773413
YAP1 induces invadopodia formation by transcriptionally activating TIAM1 through enhancer in breast cancer. PMID:35773411
The close interaction between hypoxia-related proteins and metastasis in pancarcinomas. PMID:35773405
N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma. PMID:35773310
Downregulation of DNMT3A Attenuates the Warburg Effect, Proliferation, and Invasion via Promoting the Inhibition of miR-603 on HK2 in Ovarian Cancer. PMID:35770296
Exonuclease 1 is a Potential Diagnostic and Prognostic Biomarker in Hepatocellular Carcinoma. PMID:35769911
Epigenetic dysregulation in meningiomas. PMID:35769412
Is loss of p53 a driver of ductal carcinoma in situ progression? PMID:35764786
Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma. PMID:35761940
Proceedings of the fifth international Molecular Pathological Epidemiology (MPE) meeting. PMID:35759080
Prognostic Implication and Immunological Role of PSMD2 in Lung Adenocarcinoma. PMID:35754829
A Systematic Analysis Reveals the Prognostic and Immunological Role of Reptin/RUVBL2 in Human Tumors. PMID:35754815
A new deep learning technique reveals the exclusive functional contributions of individual cancer mutations. PMID:35753349
Targeting signaling pathways in prostate cancer: mechanisms and clinical trials. PMID:35750683
POC1A, prognostic biomarker of immunosuppressive microenvironment in cancer. PMID:35748773
Precision Medicine in Head and Neck Cancers: Genomic and Preclinical Approaches. PMID:35743639
Targeting Cell Cycle Progression in HER2+ Breast Cancer: An Emerging Treatment Opportunity. PMID:35742993
Gene Expression of the D-Series Resolvin Pathway Predicts Activation of Anti-Tumor Immunity and Clinical Outcomes in Head and Neck Cancer. PMID:35742918
Delineation of Pathogenomic Insights of Breast Cancer in Young Women. PMID:35741056
Identifying the Potential Roles of PBX4 in Human Cancers Based on Integrative Analysis. PMID:35740947
NR2F1, a Tumor Dormancy Marker, Is Expressed Predominantly in Cancer-Associated Fibroblasts and Is Associated with Suppressed Breast Cancer Cell Proliferation. PMID:35740627
MCC Gene Silencing Is a CpG Island Methylator Phenotype-Associated Factor That Predisposes Colon Cancer Cells to Irinotecan and Olaparib. PMID:35740525
Metabolomic Analysis Points to Bioactive Lipid Species and Acireductone Dioxygenase 1 (ADI1) as Potential Therapeutic Targets in Poor Prognosis Endometrial Cancer. PMID:35740505
Impact of Endoluminal Radiofrequency Ablation on Immunity in Pancreatic Cancer and Cholangiocarcinoma. PMID:35740353
Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia. PMID:35739278
Expression and prognosis analysis of mitochondrial ribosomal protein family in breast cancer. PMID:35739158
Efficacy of Ipilimumab vs FOLFOX in Combination With Nivolumab and Trastuzumab in Patients With Previously Untreated ERBB2-Positive Esophagogastric Adenocarcinoma: The AIO INTEGA Randomized Clinical Trial. PMID:35737383
A Case Study of Clinical Response to Rucaparib in a Patient with Metastatic Castration-Resistant Prostate Cancer and a RAD51B Alteration. PMID:35735442
Neuroendocrine pathways and breast cancer progression: a pooled analysis of somatic mutations and gene expression from two large breast cancer cohorts. PMID:35729536
WT1-specific TCRs directed against newly identified peptides install antitumor reactivity against acute myeloid leukemia and ovarian carcinoma. PMID:35728869
Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2. PMID:35727845
Genome-wide mapping of somatic mutation rates uncovers drivers of cancer. PMID:35726091
A comprehensive bioinformatics analysis to identify potential prognostic biomarkers among CC and CXC chemokines in breast cancer. PMID:35725915
Promising prognostic value of Transglutaminase type 2 and its correlation with tumor-infiltrating immune cells in skin cutaneous melanoma. PMID:35725560
Single Circulating-Tumor-Cell-Targeted Sequencing to Identify Somatic Variants in Liquid Biopsies in Non-Small-Cell Lung Cancer Patients. PMID:35723337
Integrated Analysis of ECT2 and COL17A1 as Potential Biomarkers for Pancreatic Cancer. PMID:35722628
Mechanisms of SARS-CoV-2 and Male Infertility: Could Connexin and Pannexin Play a Role? PMID:35721552
CENP-A Regulation and Cancer. PMID:35721491
Functions of three ubiquitin-conjugating enzyme 2 genes in hepatocellular carcinoma diagnosis and prognosis. PMID:35721293
Attenuated ZHX3 expression is predictive of poor outcome for liver cancer: Indication for personalized therapy. PMID:35720472
SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma. PMID:35720314
Dual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma. PMID:35715826
Parallel and private generalized suffix tree construction and query on genomic data. PMID:35715724
MEX3A promotes the malignant progression of ovarian cancer by regulating intron retention in TIMELESS. PMID:35715407
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma. PMID:35712470
Differential Expression of Genes Regulating Store-operated Calcium Entry in Conjunction With Mitochondrial Dynamics as Potential Biomarkers for Cancer: A Single-Cell RNA Analysis. PMID:35711942
Discoidin Domain Receptor 2 Expression as Worse Prognostic Marker in Invasive Breast Cancer. PMID:35711892
Iron commensalism of mesenchymal glioblastoma promotes ferroptosis susceptibility upon dopamine treatment. PMID:35710828
Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer. PMID:35710704
Smurf2 inhibition enhances chemotherapy and radiation sensitivity in non-small-cell lung cancer. PMID:35710591
eIF6 as a Promising Diagnostic and Prognostic Biomarker for Poorer Survival of Cutaneous Melanoma. PMID:35707354
Protein Kinase C Epsilon Overexpression Is Associated With Poor Patient Outcomes in AML and Promotes Daunorubicin Resistance Through p-Glycoprotein-Mediated Drug Efflux. PMID:35707351
Identification of hub genes associated with bladder cancer using bioinformatic analyses. PMID:35706790
An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors. PMID:35705641
Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer. PMID:35705314
The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma. PMID:35703534
Comprehensive bioinformatics analysis of susceptibility genes for developmental dysplasia of the hip. PMID:35702583
Founder BRCA1 mutations in Nepalese population. PMID:35698740
EGFL7 expression profile in IDH-wildtype glioblastomas is associated with poor patient outcome. PMID:35698739
Advances in the systemic treatment of therapeutic approaches in biliary tract cancer. PMID:35696747
Multi-Omics Analysis of MCM2 as a Promising Biomarker in Pan-Cancer. PMID:35693940
Bioinformatic Analysis Identifying PSMB 1/2/3/4/6/8/9/10 as Prognostic Indicators in Clear Cell Renal Cell Carcinoma. PMID:35693739
Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients. PMID:35693094
Gastric cancer with enhanced apical junction pathway has increased metastatic potential and worse clinical outcomes. PMID:35693068
Genomic Validation of Endometrial Cancer Patient-Derived Xenograft Models as a Preclinical Tool. PMID:35682944
No Time to Die: How Kidney Cancer Evades Cell Death. PMID:35682876
SCAMP3 Regulates EGFR and Promotes Proliferation and Migration of Triple-Negative Breast Cancer Cells through the Modulation of AKT, ERK, and STAT3 Signaling Pathways. PMID:35681787
Prediction of Adrenocortical Carcinoma Relapse and Prognosis with a Set of Novel Multigene Panels. PMID:35681785
Targeted Therapy for Adrenocortical Carcinoma: A Genomic-Based Search for Available and Emerging Options. PMID:35681700
A Histone Deacetylase Inhibitor Induces Acetyl-CoA Depletion Leading to Lethal Metabolic Stress in RAS-Pathway Activated Cells. PMID:35681624
Model Cell Lines and Tissues of Different HGSOC Subtypes Differ in Local Estrogen Biosynthesis. PMID:35681563
Robustness of the Autophagy Pathway to Somatic Copy Number Losses. PMID:35681458
GNOSIS: an R Shiny app supporting cancer genomics survival analysis with cBioPortal. PMID:35677713
Clinical Relevance of Estrogen Reactivity in the Breast Cancer Microenvironment. PMID:35677163
Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant. PMID:35676284
Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation. PMID:35672316
Identification of the Putative Tumor Suppressor Characteristics of FAM107A via Pan-Cancer Analysis. PMID:35669436
A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma. PMID:35668194
Quantifying concordant genetic effects of de novo mutations on multiple disorders. PMID:35666111
Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Squamous Cell Carcinomas Identifies KMT2C as a Potential Tumor Suppressor. PMID:35664801
Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression. PMID:35664705
MCM10 is a Prognostic Biomarker and Correlated With Immune Checkpoints in Ovarian Cancer. PMID:35664337
Genetic and Epigenetic Mechanisms Deregulate the CRL2pVHL Complex in Hepatocellular Carcinoma. PMID:35664333
5-HT2B-mediated serotonin activation in enterocytes suppresses colitis-associated cancer initiation and promotes cancer progression. PMID:35664068
Hypoxia-regulated carbonic anhydrase IX (CAIX) protein is an independent prognostic indicator in triple negative breast cancer. PMID:35659359
Integrated proteogenomic characterization of urothelial carcinoma of the bladder. PMID:35659036
An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for Apc mutation-driven intestinal tumorigenesis. PMID:35658010
A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of MEK1/2 Inhibitors in NRAS Mutant Melanoma. PMID:35657206
The evolving landscape of prostate cancer somatic mutations. PMID:35657155
Prognostic and Immunological Role of PPP1R14A as a Pan-Cancer Analysis Candidate. PMID:35656324
DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD. PMID:35655269
Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers. PMID:35654828
Immune landscape of a genetically engineered murine model of glioma compared with human glioma. PMID:35653194
Pan-Cancer Analysis of the Oncogenic and Immunological Role of RCN3: A Potential Biomarker for Prognosis and Immunotherapy. PMID:35651805
Identification of an Inflammatory Response-Related Gene Signature to Predict Survival and Immune Status in Glioma Patients. PMID:35647198
Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer. PMID:35646860
Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis. PMID:35646543
S100A8 as a Promising Biomarker and Oncogenic Immune Protein in the Tumor Microenvironment: An Integrative Pancancer Analysis. PMID:35646116
YOD1 serves as a potential prognostic biomarker for pancreatic cancer. PMID:35642058
Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer. PMID:35641987
Mucinous Histology Is Associated with Resistance to Anti-EGFR Therapy in Patients with Left-Sided RAS/BRAF Wild-Type Metastatic Colorectal Cancer. PMID:35641204
UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer. PMID:35637955
Disclosing Potential Key Genes, Therapeutic Targets and Agents for Non-Small Cell Lung Cancer: Evidence from Integrative Bioinformatics Analysis. PMID:35632527
IL-13Rα2 Status Predicts GB-13 (IL13.E13K-PE4E) Efficacy in High-Grade Glioma. PMID:35631512
Validation of a Novel Three-Dimensional (3D Fusion) Gross Sampling Protocol for Clear Cell Renal Cell Carcinoma to Overcome Intratumoral Heterogeneity: The Meet-Uro 18 Study. PMID:35629151
Correlation of Immunological and Molecular Profiles with Response to Crizotinib in Alveolar Soft Part Sarcoma: An Exploratory Study Related to the EORTC 90101 "CREATE" Trial. PMID:35628499
Involvement of ORAI1/SOCE in Human AML Cell Lines and Primary Cells According to ABCB1 Activity, LSC Compartment and Potential Resistance to Ara-C Exposure. PMID:35628366
Correlation of NTRK1 Downregulation with Low Levels of Tumor-Infiltrating Immune Cells and Poor Prognosis of Prostate Cancer Revealed by Gene Network Analysis. PMID:35627227
MICAL1 Monooxygenase in Autosomal Dominant Lateral Temporal Epilepsy: Role in Cytoskeletal Regulation and Relation to Cancer. PMID:35627100
Multi-Omics Analyses to Identify FCGBP as a Potential Predictor in Head and Neck Squamous Cell Carcinoma. PMID:35626334
Viral and Genomic Drivers of Squamous Cell Neoplasms Arising in the Lacrimal Drainage System. PMID:35626161
RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk. PMID:35626096
Using GPCRs as Molecular Beacons to Target Ovarian Cancer with Nanomedicines. PMID:35625966
Making Invisible RNA Visible: Discriminative Sequencing Methods for RNA Molecules with Specific Terminal Formations. PMID:35625540
Clinical significance and correlation of PD-L1, B7-H3, B7-H4, and TILs in pancreatic cancer. PMID:35624419
Impact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival. PMID:35624283
Histologic and Genotypic Characterization of Lung Cancer in the Inuit Population of the Eastern Canadian Arctic. PMID:35621648
Tanshinone IIA protects against chronic obstructive pulmonary disease via exosome‑shuttled miR‑486‑5p. PMID:35621142
Genetic changes associated with relapse in favorable histology Wilms tumor: A Children's Oncology Group AREN03B2 study. PMID:35617957
Comprehensive Analysis of Prognostic and immune infiltrates for FOXPs Transcription Factors in Human Breast Cancer. PMID:35614183
The impact of ALDH7A1 variants in oral cancer development and prognosis. PMID:35613852
ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1. PMID:35613620
SPINDOC is Highly Expressed in Pan-Cancer Samples and Can Promote the Proliferation, Invasion and Migration of Hepatocellular Carcinoma Cells by Activating Wnt/β-Catenin Signaling Pathway. PMID:35611367
High expression of SLC20A1 is less effective for endocrine therapy and predicts late recurrence in ER-positive breast cancer. PMID:35605014
SOCS3 Acts as an Onco-immunological Biomarker With Value in Assessing the Tumor Microenvironment, Pathological Staging, Histological Subtypes, Therapeutic Effect, and Prognoses of Several Types of Cancer. PMID:35600392
Worldwide Prevalence and Clinical Characteristics of RAS Mutations in Head and Neck Cancer: A Systematic Review and Meta-Analysis. PMID:35600380
NUF2 Is a Potential Immunological and Prognostic Marker for Non-Small-Cell Lung Cancer. PMID:35600043
Cancer genomic profiling identified dihydropyrimidine dehydrogenase deficiency in bladder cancer promotes sensitivity to gemcitabine. PMID:35595780
Alarm Signal S100-Related Signature Is Correlated with Tumor Microenvironment and Predicts Prognosis in Glioma. PMID:35592707
Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells. PMID:35589724
TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signalling. PMID:35589707
Systematic Analysis of E2F Expression and Its Relation in Colorectal Cancer Prognosis. PMID:35585998
Tumor and Constitutional Sequencing for Neurofibromatosis Type 1. PMID:35584348
Non-enzymatic function of WRN RECQL helicase regulates removal of topoisomerase-I-DNA covalent complexes and triggers NF-κB signaling in cancer. PMID:35582959
PWWP2B promotes DNA end resection and homologous recombination. PMID:35582821
RET kinase alterations in targeted cancer therapy. PMID:35582449
Teaching an old dog new tricks: reactivated developmental signaling pathways regulate ABCB1 and chemoresistance in cancer. PMID:35582031
Mutational landscape of normal epithelial cells in Lynch Syndrome patients. PMID:35581206
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF. PMID:35580987
Transcriptional ITPR3 as potential targets and biomarkers for human pancreatic cancer. PMID:35580861
Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer. PMID:35579943
DPYSL2 interacts with JAK1 to mediate breast cancer cell migration. PMID:35575798
A Novel TAF-Related Signature Based on ECM Remodeling Genes Predicts Glioma Prognosis. PMID:35574375
Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation. PMID:35574218
MethylMasteR: A Comparison and Customization of Methylation-Based Copy Number Variation Calling Software in Cancers Harboring Large Scale Chromosomal Deletions. PMID:35573871
GABRP is a potential prognostic biomarker and correlated with immune infiltration and tumor microenvironment in pancreatic cancer. PMID:35571651
Identification of Novel Prognostic Biomarkers Relevant to Immune Infiltration in Lung Adenocarcinoma. PMID:35571056
Integrative analysis identifies CXCL11 as an immune-related prognostic biomarker correlated with cell proliferation and immune infiltration in multiple myeloma microenvironment. PMID:35568859
A bioinformatic analysis of WFDC2 (HE4) expression in high grade serous ovarian cancer reveals tumor-specific changes in metabolic and extracellular matrix gene expression. PMID:35568777
Cell line models for drug discovery in PIK3CA-mutated colorectal cancers. PMID:35568775
The E3 Ubiquitin Ligase Fbxo4 Functions as a Tumor Suppressor: Its Biological Importance and Therapeutic Perspectives. PMID:35565262
Patient-Derived Bladder Cancer Organoid Models in Tumor Biology and Drug Testing: A Systematic Review. PMID:35565191
Updated Functional Roles of NAMPT in Carcinogenesis and Therapeutic Niches. PMID:35565188
Prognostic and Immunotherapeutic Roles of KRAS in Pan-Cancer. PMID:35563733
The Long Non-Coding RNA HOXA-AS2 Promotes Proliferation of Glioma Stem Cells and Modulates Their Inflammation Pathway Mainly through Post-Transcriptional Regulation. PMID:35563134
Identification of HGD and GSTZ1 as Biomarkers Involved Metabolic Reprogramming in Kidney Renal Clear Cell Carcinoma. PMID:35562974
Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma. PMID:35562868
Integrated computational analysis reveals HOX genes cluster as oncogenic drivers in head and neck squamous cell carcinoma. PMID:35562533
SNAT7 regulates mTORC1 via macropinocytosis. PMID:35561222
Assessing the Potential Prognostic and Immunological Role of TK1 in Prostate Cancer. PMID:35559045
A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple Tumors. PMID:35559034
Retracted Article: Long non-coding RNA KCNQ1OT1 promotes osteosarcoma progression by increasing β-catenin activity. PMID:35558611
A Community-Driven, Openly Accessible Molecular Pathway Integrating Knowledge on Malignant Pleural Mesothelioma. PMID:35558518
Multi-Omics Analysis of the Prognosis and Biological Function for TRPV Channel Family in Clear Cell Renal Cell Carcinoma. PMID:35558077
Identification of a novel autophagy-related prognostic signature and small molecule drugs for glioblastoma by bioinformatics. PMID:35550147
CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies. PMID:35550030
Identification of Neoantigens and Construction of Immune Subtypes in Prostate Adenocarcinoma. PMID:35547260
FMRP ligand circZNF609 destabilizes RAC1 mRNA to reduce metastasis in acral melanoma and cutaneous melanoma. PMID:35534866
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. PMID:35534777
Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. PMID:35533575
The Role of CTNNB1 in Endometrial Cancer. PMID:35531470
Mining the prognostic significance and immune infiltration of STAT family members in human breast cancer by bioinformatics analysis. PMID:35531108
ZAP70 Activation Compensates for Loss of Class IA PI3K Isoforms Through Activation of the JAK-STAT3 Pathway. PMID:35530641
The interaction of p53 and DNA repair gene mutations and their impact on tumor mutation burden and immune response in human malignancies. PMID:35530277
Low HECTD1 mRNA expression is associated with poor prognosis and may be correlated with increased mitochondrial respiratory function in breast cancer. PMID:35530276
How often is each gene mutated within the cancer patient population? PMID:35529901
Integrated proteomic analysis of low-grade gliomas reveals contributions of 1p-19q co-deletion to oligodendroglioma. PMID:35526077
Prognostic value and immune characteristics of RUNX gene family in human cancers: a pan-cancer analysis. PMID:35522574
Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration. PMID:35521520
The Apoptotic Resistance of BRCA1-Deficient Ovarian Cancer Cells is Mediated by cAMP. PMID:35517499
Pan-cancer analysis reveals RIPK2 predicts prognosis and promotes immune therapy resistance via triggering cytotoxic T lymphocytes dysfunction. PMID:35508972
Survival-related genes are diversified across cancers but generally enriched in cancer hallmark pathways. PMID:35508961
One-step nucleic acid amplification for intraoperative diagnosis of lymph node metastasis in lung cancer patients: a single-center prospective study. PMID:35508484
Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages. PMID:35508466
BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity. PMID:35507536
VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells. PMID:35505422
Preliminary study on the role of the C5orf46 gene in renal cancer. PMID:35504177
Targeting SHP2 phosphatase in hematological malignancies. PMID:35503226
Essential m6A Methylation Regulator HNRNPC Serves as a Targetable Biomarker for Papillary Renal Cell Carcinoma. PMID:35502201
The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression. PMID:35501464
Olfactory Receptor OR2H1 Is an Effective Target for CAR T Cells in Human Epithelial Tumors. PMID:35499393
Identifying novel SMYD3 interactors on the trail of cancer hallmarks. PMID:35495117
Anchored Multiplex PCR Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA. PMID:35494035
TIM-3 Expression Level on AML Blasts Correlates With Presence of Core Binding Factor Translocations Rather Than Clinical Outcomes. PMID:35494006
Inhibiting 3βHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer. PMID:35492874
Increased expression of RUNX3 inhibits normal human myeloid development. PMID:35490198
Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer. PMID:35488350
Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response. PMID:35488273
Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors. PMID:35484114
Identification of IMPA2 as the hub gene associated with colorectal cancer and liver metastasis by integrated bioinformatics analysis. PMID:35483170
Functional network analysis of p85 and PI3K as potential gene targets and mechanism of oleanolic acid in overcoming breast cancer resistance to tamoxifen. PMID:35482141
ToPP: Tumor online prognostic analysis platform for prognostic feature selection and clinical patient subgroup selection. PMID:35479398
DNA Polymerase Delta 1 Catalytic Subunit (POLD1) as a Prognostic Factor in Clear Cell Renal Cell Carcinoma Patients. PMID:35478106
NSC305787, a pharmacological ezrin inhibitor, exhibits antineoplastic activity in pancreatic cancer cells. PMID:35477813
Structure of human chromatin-remodelling PBAF complex bound to a nucleosome. PMID:35477757
PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy. PMID:35477555
ETS transcription factor ELF3 (ESE-1) is a cell cycle regulator in benign and malignant prostate. PMID:35472129
Role of ANO1 in tumors and tumor immunity. PMID:35471604
Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows. PMID:35468810
Comprehensive analysis of the expression, prognosis, and immune infiltrates for CHDs in human lung cancer. PMID:35467222
Role of the Mosaic Cisternal Maturation Machinery in Glycan Synthesis and Oncogenesis. PMID:35465326
Identification and Validation of Chromobox Family Members as Potential Prognostic Biomarkers and Therapeutic Targets for Human Esophageal Cancer. PMID:35464847
Construction of a Two-Gene Immunogenomic-Related Prognostic Signature in Lung Squamous Cell Carcinoma. PMID:35463955
Lapatinib Suppresses HER2-Overexpressed Cholangiocarcinoma and Overcomes ABCB1- Mediated Gemcitabine Chemoresistance. PMID:35463361
In the Tumor Microenvironment, ETS1 Is an Oncogenic Immune Protein: An Integrative Pancancer Analysis. PMID:35463077
Identification of a Four-Gene Metabolic Signature to Evaluate the Prognosis of Colon Adenocarcinoma Patients. PMID:35462848
Blood-Based Next-Generation Sequencing in Adrenocortical Carcinoma. PMID:35462410
Characterization of transcriptome diversity and in vitro behavior of primary human high-risk breast cells. PMID:35459280
Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer. PMID:35456049
Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia. PMID:35454946
A Bioinformatics Evaluation of the Role of Dual-Specificity Tyrosine-Regulated Kinases in Colorectal Cancer. PMID:35454940
Combined Alcohol Exposure and KRAS Mutation in Human Pancreatic Ductal Epithelial Cells Induces Proliferation and Alters Subtype Signatures Determined by Multi-Omics Analysis. PMID:35454872
The Purinergic Landscape of Non-Small Cell Lung Cancer. PMID:35454832
Comprehensive Analysis Identifies Ameloblastin-Related Competitive Endogenous RNA as a Prognostic Biomarker for Testicular Germ Cell Tumour. PMID:35454778
Prostanoid Signaling in Cancers: Expression and Regulation Patterns of Enzymes and Receptors. PMID:35453789
Extracellular Vesicles Derived from SIPA1high Breast Cancer Cells Enhance Macrophage Infiltration and Cancer Metastasis through Myosin-9. PMID:35453742
Integrated In Silico Analyses Identify PUF60 and SF3A3 as New Spliceosome-Related Breast Cancer RNA-Binding Proteins. PMID:35453681
BRD4 Targets the KEAP1-Nrf2-G6PD Axis and Suppresses Redox Metabolism in Small Cell Lung Cancer. PMID:35453346
Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity. PMID:35449156
Immunogenic Cell Death-Relevant Damage-Associated Molecular Patterns and Sensing Receptors in Triple-Negative Breast Cancer Molecular Subtypes and Implications for Immunotherapy. PMID:35444934
Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Gliomas. PMID:35444654
TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer. PMID:35444240
Evaluation of a seven gene mutational profile as a prognostic factor in a population-based study of clear cell renal cell carcinoma. PMID:35444164
GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers. PMID:35440675
Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts. PMID:35440124
Ubiquitylation of unphosphorylated c-myc by novel E3 ligase SCFFbxl8. PMID:35438057
Co-expression patterns explain how a basic transcriptional role for MYC modulates Wnt and MAPK pathways in colon and lung adenocarcinomas. PMID:35438040
Cross-Platform in-silico Analyses Exploring Tumor Immune Microenvironment with Prognostic Value in Triple-Negative Breast Cancer. PMID:35437353
Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. PMID:35437317
PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer. PMID:35437307
Comprehensive Analysis on Prognosis and Immune Infiltration of Lysyl Oxidase Family Members in Pancreatic Adenocarcinoma With Experimental Verification. PMID:35433829
Up-to-Date Pathologic Classification and Molecular Characteristics of Intrahepatic Cholangiocarcinoma. PMID:35433771
The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients. PMID:35433488
The Prognostic Value and Immune Infiltration of USP10 in Pan-Cancer: A Potential Therapeutic Target. PMID:35433424
Identification and validation of EMT-immune-related prognostic biomarkers CDKN2A, CMTM8 and ILK in colon cancer. PMID:35429970
Identification of Novel Genes and Associated Drugs in Cervical Cancer by Bioinformatics Methods. PMID:35428744
Pan‑cancer analyses reveal the regulation and clinical outcome association of PCLAF in human tumors. PMID:35425993
BAP1-Related ceRNA (NEAT1/miR-10a-5p/SERPINE1) Promotes Proliferation and Migration of Kidney Cancer Cells. PMID:35425712
Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome. PMID:35422502
SLC1A5 Prefers to Play as an Accomplice Rather Than an Opponent in Pancreatic Adenocarcinoma. PMID:35419359
Targeting Epigenetic Regulatory Enzymes for Cancer Therapeutics: Novel Small-Molecule Epidrug Development. PMID:35419278
Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology. PMID:35418942
The Potential Role of Genomic Signature in Stage II Relapsed Colorectal Cancer (CRC) Patients: A Mono-Institutional Study. PMID:35418781
The kinesin KIF20A promotes progression to castration-resistant prostate cancer through autocrine activation of the androgen receptor. PMID:35418689
A pan-cancer analysis of GINS complex subunit 4 to identify its potential role as a biomarker in multiple human cancers. PMID:35411239
Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism. PMID:35411077
EGFR Mutations in Head and Neck Squamous Cell Carcinoma. PMID:35409179
Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma. PMID:35409173
BRCA1/2 Serves as a Biomarker for Poor Prognosis in Breast Carcinoma. PMID:35409110
High Risk-Human Papillomavirus in HNSCC: Present and Future Challenges for Epigenetic Therapies. PMID:35408843
RNA Editing in Glioma as a Sexually Dimorphic Prognostic Factor That Affects mRNA Abundance in Fatty Acid Metabolism and Inflammation Pathways. PMID:35406793
Genetic Clonality as the Hallmark Driving Evolution of Non-Small Cell Lung Cancer. PMID:35406585
TIA1 Loss Exacerbates Fatty Liver Disease but Exerts a Dual Role in Hepatocarcinogenesis. PMID:35406476
CRABP1 in Non-Canonical Activities of Retinoic Acid in Health and Diseases. PMID:35406141
Regulation of growth, invasion and metabolism of breast ductal carcinoma through CCL2/CCR2 signaling interactions with MET receptor tyrosine kinases. PMID:35405500
Integrated bioinformatic pipeline using whole-exome and RNAseq data to identify germline variants correlated with cancer. PMID:35403010
DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination. PMID:35402838
PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? PMID:35402264
Proteomic-Based Machine Learning Analysis Reveals PYGB as a Novel Immunohistochemical Biomarker to Distinguish Inverted Urothelial Papilloma From Low-Grade Papillary Urothelial Carcinoma With Inverted Growth. PMID:35402263
Urine- and Blood-Based Molecular Profiling of Human Prostate Cancer. PMID:35402245
ZNF143 Expression is Associated with COPD and Tumor Microenvironment in Non-Small Cell Lung Cancer. PMID:35400998
Clinicopathologic and molecular characteristics of EGFR-mutant lung adenocarcinomas that transform to small cell lung cancer after TKI therapy. PMID:35399568
The downregulation of fibrinogen-like protein 1 inhibits the proliferation of lung adenocarcinoma via regulating MYC-target genes. PMID:35399566
Development of Tumor Mutation Burden-Related Prognostic Model and Novel Biomarker Identification in Stomach Adenocarcinoma. PMID:35399509
Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors. PMID:35395865
TET1 mutations as a predictive biomarker for immune checkpoint inhibitors in colon adenocarcinoma. PMID:35395805
Construction of Bone Metastasis-Specific Regulation Network Based on Prognostic Stemness-Related Signatures in Prostate Cancer. PMID:35392496
Mammaglobin, GATA-binding protein 3 (GATA3), and epithelial growth factor receptor (EGFR) expression in different breast cancer subtypes and their clinical significance. PMID:35388661
CRIA: An Interactive Gene Selection Algorithm for Cancers Prediction Based on Copy Number Variations. PMID:35386679
The Valuable Role of ARMC1 in Invasive Breast Cancer as a Novel Biomarker. PMID:35378785
The Role of the TP53 Pathway in Predicting Response to Neoadjuvant Therapy in Esophageal Adenocarcinoma. PMID:35377946
Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors. PMID:35373300
Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention. PMID:35373279
Comprehensive Analysis of SMC Gene Family Prognostic Value and Immune Infiltration in Patients With Pancreatic Adenocarcinoma. PMID:35372377
The AlkB Family: Potential Prognostic Biomarkers and Therapeutic Targets in Glioblastoma. PMID:35371987
Prognostic Values and Underlying Regulatory Network of Cohesin Subunits in Esophageal Carcinoma. PMID:35371307
Expression and Regulation Network of HDAC3 in Acute Myeloid Leukemia and the Implication for Targeted Therapy Based on Multidataset Data Mining. PMID:35371279
The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells. PMID:35371049
Cleavage Stimulation Factor Subunit 2: Function Across Cancers and Potential Target for Chemotherapeutic Drugs. PMID:35370655
CEMIP as a potential biomarker and therapeutic target for breast cancer patients. PMID:35370456
Circulating Tumor Cell-Free DNA Genes as Prognostic Gene Signature for Platinum Resistant Ovarian Cancer Diagnosis. PMID:35370397
Retinoblastoma Protein Paralogs and Tumor Suppression. PMID:35368709
One Ferroptosis-Related Gene-Pair Signature Serves as an Original Prognostic Biomarker in Lung Adenocarcinoma. PMID:35368652
cSurvival: a web resource for biomarker interactions in cancer outcomes and in cell lines. PMID:35368077
Mutant p53: it's not all one and the same. PMID:35361963
USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy. PMID:35361799
New Insights Into PTBP3 in Human Cancers: Immune Cell Infiltration, TMB, MSI, PDCD1 and m6A Markers. PMID:35359851
Estrogen-Related Receptors Gene Expression and Copy Number Alteration Association With the Clinicopathologic Characteristics of Breast Cancer. PMID:35359609
Upregulation of Yin-Yang-1 Associates with Proliferation and Glutamine Metabolism in Esophageal Carcinoma. PMID:35359580
Comprehensive Analysis of the Differential Expression and Prognostic Value of Histone Deacetylases in Glioma. PMID:35359455
A Pan-Cancer Bioinformatic Analysis of RAD51 Regarding the Values for Diagnosis, Prognosis, and Therapeutic Prediction. PMID:35359409
Single-Cell RNA Sequencing Revealed a 3-Gene Panel Predicted the Diagnosis and Prognosis of Thyroid Papillary Carcinoma and Associated With Tumor Immune Microenvironment. PMID:35359404
Ultrasensitive profiling of UV-induced mutations identifies thousands of subclinical facial tumors in tuberous sclerosis complex. PMID:35358092
PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer. PMID:35357905
BCL6 and the Notch pathway: a signaling axis leading to a novel druggable biotarget in triple negative breast cancer. PMID:35357654
OmicsView: Omics data analysis through interactive visual analytics. PMID:35356547
SNRPD1/E/F/G Serve as Potential Prognostic Biomarkers in Lung Adenocarcinoma. PMID:35356432
Anatomic position determines oncogenic specificity in melanoma. PMID:35355015
KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis. PMID:35354467
Searching of Clinical Trials Made Easier in cBioPortal Using Patients' Genetic and Clinical Profiles. PMID:35354211
Bioinformatics Analysis Combined With Experiments Predicts PUDP as a Potential Prognostic Biomarker for Hepatocellular Carcinoma Through Its Interaction With Tumor Microenvironment. PMID:35350563
MCL-1 is a clinically targetable vulnerability in breast cancer. PMID:35349392
Multi-omics analyses provide novel biological insights to distinguish lobular ductal types of invasive breast cancers. PMID:35348974
Clinical significance of FBXW7 loss of function in human cancers. PMID:35346215
Prognostic significance of SNCA and its methylation in bladder cancer. PMID:35346107
Aberrant SKP1 Expression: Diverse Mechanisms Impacting Genome and Chromosome Stability. PMID:35345853
A systematic pan-cancer study demonstrates the oncogenic function of heterogeneous nuclear ribonucleoprotein C. PMID:35344508
Four m6A RNA Methylation Gene Signatures and Their Prognostic Values in Lung Adenocarcinoma. PMID:35343834
Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression. PMID:35340765
Glycoprotein hormone α-subunit promotes cell proliferation and tumorigenesis in breast cancer. PMID:35340558
Upregulated phospholipase D2 expression and activity is related to the metastatic properties of melanoma. PMID:35340556
Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers. PMID:35338148
Significant Roles of Notch O-Glycosylation in Cancer. PMID:35335147
Tumor-associated macrophages related signature in glioma. PMID:35332109
Pan-cancer analysis identifies BIRC5 as a prognostic biomarker. PMID:35331169
High Mutation Burden in ER-Positive/HER2-Negative/Luminal Breast Cancers. PMID:35329928
Oncogenic Pathways in Neurodegenerative Diseases. PMID:35328644
LPPR5 Expression in Glioma Affects Growth, Vascular Architecture, and Sunitinib Resistance. PMID:35328529
Gene Expression Analysis of Biphasic Pleural Mesothelioma: New Potential Diagnostic and Prognostic Markers. PMID:35328227
p53 Immunohistochemistry and Mutation Types Mismatching in High-Grade Serous Ovarian Cancer. PMID:35328131
Visualization of the Effect of Assay Size on the Error Profile of Tumor Mutational Burden Measurement. PMID:35327986
Impact of miR-1/miR-133 Clustered miRNAs: PFN2 Facilitates Malignant Phenotypes in Head and Neck Squamous Cell Carcinoma. PMID:35327465
At the Intersection of Cardiology and Oncology: TGFβ as a Clinically Translatable Therapy for TNBC Treatment and as a Major Regulator of Post-Chemotherapy Cardiomyopathy. PMID:35326728
Toward Targeted Therapies in Oesophageal Cancers: An Overview. PMID:35326673
Transcriptional Profiling of Malignant Melanoma Reveals Novel and Potentially Targetable Gene Fusions. PMID:35326655
Circulating Tumor DNA Profiling of a Diffuse Large B Cell Lymphoma Patient with Secondary Acute Myeloid Leukemia. PMID:35326522
SWI/SNF Antagonism of PRC2 Mediates Estrogen-Induced Progesterone Receptor Expression. PMID:35326450
Redox-Related Proteins in Melanoma Progression. PMID:35326089
Bioinformatics Analysis and Identification of Potential Genes Associated with Pathogenesis and Prognosis of Gastric Cancer. PMID:35325407
Urothelial Bladder Carcinomas with High Tumor Mutation Burden Have a Better Prognosis and Targetable Molecular Defects beyond Immunotherapies. PMID:35323317
SWI/SNF Chromatin Remodeling Enzymes in Melanoma. PMID:35323214
Chemokine CCL17 Affects Local Immune Infiltration Characteristics and Early Prognosis Value of Lung Adenocarcinoma. PMID:35321241
Prognostic and biological role of the N-Myc downstream-regulated gene family in hepatocellular carcinoma. PMID:35321174
Comprehensive bioinformatic analysis reveals oncogenic role of H2A.Z isoforms in cervical cancer progression. PMID:35317119
Reductive TCA cycle catalyzed by wild-type IDH2 promotes acute myeloid leukemia and is a metabolic vulnerability for potential targeted therapy. PMID:35313945
Heat Shock Proteins and HSF1 in Cancer. PMID:35311075
The Pan-Cancer Crosstalk Between the EFNA Family and Tumor Microenvironment for Prognosis and Immunotherapy of Gastric Cancer. PMID:35309935
Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium. PMID:35309931
Construction of a Pyroptosis-Related Signature for Prognostic Prediction and Characterization of Immune Microenvironment in Acute Myelogenous Leukemia. PMID:35308573
Evaluation of Targeted Next-Generation Sequencing for the Management of Patients Diagnosed with a Cancer of Unknown Primary. PMID:35305098
The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers. PMID:35304457
p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases. PMID:35304445
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia. PMID:35301220
Multidimensional Analysis of CHMP Family Members in Hepatocellular Carcinoma. PMID:35300135
Identification of IL20RB as a Novel Prognostic and Therapeutic Biomarker in Clear Cell Renal Cell Carcinoma. PMID:35299868
Roles of Pyroptosis-Related Gene Signature in Prediction of Endometrial Cancer Outcomes. PMID:35299842
HER2 expression, copy number variation and survival outcomes in HER2-low non-metastatic breast cancer: an international multicentre cohort study and TCGA-METABRIC analysis. PMID:35296300
DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation. PMID:35296003
The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes. PMID:35294876
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. PMID:35294260
Aberrations in SMAD family of genes among HNSCC patients. PMID:35291342
vWCluster: Vector-valued optimal transport for network based clustering using multi-omics data in breast cancer. PMID:35286348
Evaluation of the Prognostic Relevance of Differential Claudin Gene Expression Highlights Claudin-4 as Being Suppressed by TGFβ1 Inhibitor in Colorectal Cancer. PMID:35281827
Dishevelled-Associated Activator of Morphogenesis 2 (DAAM2) Predicts the Immuno-Hot Phenotype in Pancreatic Adenocarcinoma. PMID:35281277
Anaplastic thyroid cancer: genome-based search for new targeted therapy options. PMID:35275096
Pan-Cancer Transcriptome and Immune Infiltration Analyses Reveal the Oncogenic Role of Far Upstream Element-Binding Protein 1 (FUBP1). PMID:35274005
Comprehensive Analyses of the Immunological and Prognostic Roles of an IQGAP3AR/let-7c-5p/IQGAP3 Axis in Different Types of Human Cancer. PMID:35274003
A saturation-mutagenesis analysis of the interplay between stability and activation in Ras. PMID:35272765
Production and Stabilization of Specific Upregulated Long Noncoding RNA HOXD-AS2 in Glioblastomas Are Mediated by TFE3 and miR-661, Respectively. PMID:35269968
CK1 Is a Druggable Regulator of Microtubule Dynamics and Microtubule-Associated Processes. PMID:35267653
Understanding Retinoblastoma Post-Translational Regulation for the Design of Targeted Cancer Therapies. PMID:35267571
Evaluation of the Clinical Utility of Genomic Profiling to Inform Selection of Clinical Trial Therapy in Salivary Gland Cancer. PMID:35267442
Long Noncoding RNA LOC554202 Predicts a Poor Prognosis and Correlates with Immune Infiltration in Thyroid Cancer. PMID:35265169
MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization. PMID:35264604
Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas. PMID:35264242
RNA-seq and integrated network analysis reveals the hub genes and key pathway of paclitaxel inhibition on Adriamycin resistant diffuse large B cell lymphoma cells. PMID:35263200
Assessment of POLE and POLD1 mutations as prognosis and immunotherapy biomarkers for stomach adenocarcinoma. PMID:35261896
Pan-cancer analysis of osteogenesis imperfecta causing gene SERPINF1. PMID:35261846
H2AX mRNA expression reflects DNA repair, cell proliferation, metastasis, and worse survival in breast cancer. PMID:35261802
Upregulation of Cyclin B2 (CCNB2) in breast cancer contributes to the development of lymphovascular invasion. PMID:35261781
ATP13A3 facilitates polyamine transport in human pancreatic cancer cells. PMID:35260637
Polo-like kinases as potential targets and PLK2 as a novel biomarker for the prognosis of human glioblastoma. PMID:35256538
UBIAD1 and CoQ10 protect melanoma cells from lipid peroxidation-mediated cell death. PMID:35255427
Comprehensive analyses of prognostic biomarkers and immune infiltrates among histone lysine demethylases (KDMs) in hepatocellular carcinoma. PMID:35254477
Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development. PMID:35252866
CNViz: An R/Shiny Application for Interactive Copy Number Variant Visualization in Cancer. PMID:35251754
Computational simulations of identified marine-derived natural bioactive compounds as potential inhibitors of oral cancer. PMID:35251696
A single-nucleotide-polymorphism in the 5'-flanking region of MSX1 gene as a predictive marker candidate for platinum-based therapy of esophageal carcinoma. PMID:35251318
Comprehensive Analysis of HOX Family Members as Novel Diagnostic and Prognostic Markers for Hepatocellular Carcinoma. PMID:35251173
High RAD51 gene expression is associated with aggressive biology and with poor survival in breast cancer. PMID:35249172
Cellular mechanisms underlying response and resistance to CDK4/6 inhibitors in the treatment of hormone receptor-positive breast cancer. PMID:35248122
DrGA: cancer driver gene analysis in a simpler manner. PMID:35247965
RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition. PMID:35247929
Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis. PMID:35246964
Abnormal expression and the significant prognostic value of aquaporins in clear cell renal cell carcinoma. PMID:35245343
DYRK1A suppression attenuates HIF‑1α accumulation and enhances the anti‑liver cancer effects of regorafenib and sorafenib under hypoxic conditions. PMID:35244188
Pan-Cancer Analysis Predicts FOXS1 as a Key Target in Prognosis and Tumor Immunotherapy. PMID:35241932
Pan-cancer analysis of ARID family members as novel biomarkers for immune checkpoint inhibitor therapy. PMID:35239432
Gα12 and Gα13: Versatility in Physiology and Pathology. PMID:35237598
Comprehensive Analysis of Immune Implications and Prognostic Value of SPI1 in Gastric Cancer. PMID:35237521
Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin. PMID:35235808
Computational Resources for the Interpretation of Variations in Cancer. PMID:35230689
Experimental models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor. PMID:35228656
Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) expression in glioblastoma is driven by ETS1- and MYBL2-dependent transcriptional activation. PMID:35228525
Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study. PMID:35227109
Ruthenium(ii)-arene complexes as anti-metastatic agents, and related techniques. PMID:35224494
Diagnostic, Therapeutic, and Prognostic Value of the m6A Writer Complex in Hepatocellular Carcinoma. PMID:35223847
Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms. PMID:35223844
Inhibition of NEK7 Suppressed Hepatocellular Carcinoma Progression by Mediating Cancer Cell Pyroptosis. PMID:35223495
Guanylate-Binding Protein 1 as a Potential Predictor of Immunotherapy: A Pan-Cancer Analysis. PMID:35222540
A DNA-Methylation-Driven Genes Based Prognostic Signature Reveals Immune Microenvironment in Pancreatic Cancer. PMID:35222383
Therapeutic effects of TM4SF5-targeting chimeric and humanized monoclonal antibodies in hepatocellular and colon cancer models. PMID:35211652
Pan-Cancer Analysis of Microfibrillar-Associated Protein 2 (MFAP2) Based on Bioinformatics and qPCR Verification. PMID:35211173
A Review of Circulating Tumor DNA in the Diagnosis and Monitoring of Esophageal Cancer. PMID:35210388
Expression profile and prognostic values of Chromobox family members in human glioblastoma. PMID:35210369
Mutational Landscape and Actionable Target Rates on Advanced Stage Refractory Cancer Patients: A Multicenter Chilean Experience. PMID:35207683
Ki67 and LSD1 Expression in Testicular Germ Cell Tumors Is Not Associated with Patient Outcome: Investigation Using a Digital Pathology Algorithm. PMID:35207551
Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment. PMID:35205761
Global Genomic and Proteomic Analysis Identified Critical Pathways Modulated by Proto-Oncogene PELP1 in TNBC. PMID:35205680
Discoidin Domain Receptor 1 Expression in Colon Cancer: Roles and Prognosis Impact. PMID:35205677
The Role of VHL in the Development of von Hippel-Lindau Disease and Erythrocytosis. PMID:35205407
A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors. PMID:35205150
Identification of Key Proteins from the Alternative Lengthening of Telomeres-Associated Promyelocytic Leukemia Nuclear Bodies Pathway. PMID:35205052
Exploring the Wnt Pathway as a Therapeutic Target for Prostate Cancer. PMID:35204808
Vulnerability of Triple-Negative Breast Cancer to Saponin Formosanin C-Induced Ferroptosis. PMID:35204181
Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma. PMID:35203444
Normal and Neoplastic Growth Suppression by the Extended Myc Network. PMID:35203395
Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer. PMID:35201488
A Case Series of Metastatic Malignant Gastrointestinal Neuroectodermal Tumors and Comprehensive Genomic Profiling Analysis of 20 Cases. PMID:35200608
Identification of the gene expression changes and gene regulatory aspects in ELF3 mutant bladder cancer. PMID:35199247
Robust Prediction of Prognosis and Immunotherapeutic Response for Clear Cell Renal Cell Carcinoma Through Deep Learning Algorithm. PMID:35197975
Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization. PMID:35197571
Survival Genie, a web platform for survival analysis across pediatric and adult cancers. PMID:35197510
Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. PMID:35197475
PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer. PMID:35197445
IDH1/2 mutations in acute myeloid leukemia. PMID:35197370
A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer. PMID:35196489
The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization. PMID:35193494
A Comprehensive Prognostic Analysis of POLD1 in Hepatocellular Carcinoma. PMID:35189839
Comprehensive Analysis of the Prognostic and Immunological Role of PAFAH1B in Pan-Cancer. PMID:35187070
A Prognostic Model for Acute Myeloid Leukemia Based on IL-2/STAT5 Pathway-Related Genes. PMID:35186733
NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model. PMID:35186194
Adult Wilms Tumor: Genetic Evidence of Origin of a Subset of Cases From Metanephric Adenoma. PMID:35184066
New insights on familial colorectal cancer type X syndrome. PMID:35181726
Comprehensive analysis of the expression and significance of CXCLs in human diffuse large B-cell lymphoma. PMID:35181719
PIK3CA co-occurring mutations and copy-number gain in hormone receptor positive and HER2 negative breast cancer. PMID:35181669
RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer. PMID:35179959
Transcriptomic Mapping of Non-Small Cell Lung Cancer K-RAS p.G12C Mutated Tumors: Identification of Surfaceome Targets and Immunologic Correlates. PMID:35178045
Tumor stromal nicotinamide N-methyltransferase overexpression as a prognostic biomarker for poor clinical outcome in early-stage colorectal cancer. PMID:35177765
Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition. PMID:35177674
Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways. PMID:35177083
The Genomics of Colorectal Cancer in Populations with African and European Ancestry. PMID:35176763
MECOM/PRDM3 and PRDM16 Serve as Prognostic-Related Biomarkers and Are Correlated With Immune Cell Infiltration in Lung Adenocarcinoma. PMID:35174083
The Mechanism and Prognostic Value of DNA Polymerase δ Subunits in Hepatocellular Carcinoma: Implications for Precision Therapy. PMID:35173474
YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia. PMID:35170430
A gene signature consisting of ubiquitin ligases and deubiquitinating enzymes of SKP2 is associated with clinical outcome in breast cancer. PMID:35169199
Exploring ALDH2 expression and immune infiltration in HNSC and its correlation of prognosis with gender or alcohol intake. PMID:35169188
ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma. PMID:35167193
A pan-cancer analysis of molecular characteristics and oncogenic role of gasdermins. PMID:35164740
The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells. PMID:35163828
Deciphering Genetic Alterations of Taiwanese Patients with Pancreatic Adenocarcinoma through Targeted Sequencing. PMID:35163506
EVI1 Promotes the Proliferation and Invasive Properties of Human Head and Neck Squamous Cell Carcinoma Cells. PMID:35162973
p53 Promotes Cytokine Expression in Melanoma to Regulate Drug Resistance and Migration. PMID:35159215
Identification of a Gene-Expression-Based Surrogate of Genomic Instability during Oral Carcinogenesis. PMID:35159101
Dissecting TET2 Regulatory Networks in Blood Differentiation and Cancer. PMID:35159097
AKR1B1 as a Prognostic Biomarker of High-Grade Serous Ovarian Cancer. PMID:35159076
Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice. PMID:35159064
Targeting Oncogenic Pathways in the Era of Personalized Oncology: A Systemic Analysis Reveals Highly Mutated Signaling Pathways in Cancer Patients and Potential Therapeutic Targets. PMID:35158934
New Insights on the Genetics of Pheochromocytoma and Paraganglioma and Its Clinical Implications. PMID:35158861
DNA Methylome Changes of Muscle- and Neuronal-Related Processes Precede Bladder Cancer Invasiveness. PMID:35158756
ITIH5-Derived Polypeptides Covering the VIT Domain Suppress the Growth of Human Cancer Cells In Vitro. PMID:35158755
Over-Expression and Prognostic Significance of FATP5, as a New Biomarker, in Colorectal Carcinoma. PMID:35155561
It's Getting Complicated-A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy. PMID:35155432
STIL Acts as an Oncogenetic Driver in a Primary Cilia-Dependent Manner in Human Cancer. PMID:35155425
Comprehensive and Integrative Analysis of Two Novel SARS-CoV-2 Entry Associated Proteases CTSB and CTSL in Healthy Individuals and Cancer Patients. PMID:35155389
A Pan-Cancer Analysis of the Oncogenic Role of Nuclear Transport Factor 2 in Human Cancers. PMID:35155261
A New Strategy to Identify ceRNA-Based CCDC144NL-AS1/SERPINE1 Regulatory Axis as a Novel Prognostic Biomarker for Stomach Adenocarcinoma via High Throughput Transcriptome Data Mining and Computational Verification. PMID:35155200
Intestinal Stem Cell Marker ASCL2 is a Novel Prognostic Predictor in Esophageal Adenocarcinoma. PMID:35154991
The DNA damage repair landscape in Black women with breast cancer. PMID:35154416
Identification of a Novel Nomogram to Predict Progression Based on the Circadian Clock and Insights Into the Tumor Immune Microenvironment in Prostate Cancer. PMID:35154101
Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer. PMID:35153749
Genome Nexus: A Comprehensive Resource for the Annotation and Interpretation of Genomic Variants in Cancer. PMID:35148171
HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer. PMID:35144669
Cancer and COVID-19 Susceptibility and Severity: A Two-Sample Mendelian Randomization and Bioinformatic Analysis. PMID:35141230
Pan-Cancer Analyses Reveal Oncogenic Role and Prognostic Value of F-Box Only Protein 22. PMID:35141150
A platform for oncogenomic reporting and interpretation. PMID:35140225
CPNE1 is a potential prognostic biomarker, associated with immune infiltrates and promotes progression of hepatocellular carcinoma. PMID:35139863
The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders. PMID:35136038
A data management infrastructure for the integration of imaging and omics data in life sciences. PMID:35130839
Chemogenomic and bioinformatic profiling of ERdj paralogs underpins their unique roles in cancer. PMID:35129801
Prognostic Bone Metastasis-Associated Immune-Related Genes Regulated by Transcription Factors in Mesothelioma. PMID:35127947
Identification of Tumor Antigens and Design of mRNA Vaccine for Colorectal Cancer Based on the Immune Subtype. PMID:35127707
Prognostic Implication and Oncogenic Role of PNPO in Pan-Cancer. PMID:35127701
Positive predictive value of ERBB2 copy number gain by tissue or circulating tumor DNA next-generation sequencing across advanced cancers. PMID:35126865
Genetic Alteration, Prognostic and Immunological Role of Acyl-CoA Synthetase Long-Chain Family Member 4 in a Pan-Cancer Analysis. PMID:35126480
Systematic Analysis of Expression and Prognostic Values of Lysyl Oxidase Family in Gastric Cancer. PMID:35126449
When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer. PMID:35123413
Discovery through clinical sequencing in oncology. PMID:35122052
MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination. PMID:35122005
Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumor immunity. PMID:35121862
Exploiting the tumor-suppressive activity of the androgen receptor by CDK4/6 inhibition in castration-resistant prostate cancer. PMID:35121110
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients. PMID:35120664
Bioinformatics analysis of the clinical relevance of CDCA gene family in prostate cancer. PMID:35119046
Gene Expression-Based Predication of RNA Pseudouridine Modification in Tumor Microenvironment and Prognosis of Glioma Patients. PMID:35118063
COL4A family: potential prognostic biomarkers and therapeutic targets for gastric cancer. PMID:35117889
Identification of biomarkers in colon cancer based on bioinformatic analysis. PMID:35117850
Bioinformatics analysis of BUB1 expression and gene regulation network in lung adenocarcinoma. PMID:35117845
KIT/PDGFRA/KDR amplification defines a novel molecular subtype of adenoid cystic carcinoma patients who may benefit from treatment with tyrosine kinase inhibitors. PMID:35117834
GLUT1/3/4 as novel biomarkers for the prognosis of human breast cancer. PMID:35117597
Non-SMC condensin I complex subunit H (NCAPH), a regulator of cell cycle, predicts poor prognosis in lung adenocarcinoma patients: a study mainly based on TCGA and GEO database. PMID:35117357
Epithelial-mesenchymal transition classification of circulating tumor cells in lung and colon cancer patients: potential role in clinical practice. PMID:35117274
Comprehensive analysis of the NME gene family functions in breast cancer. PMID:35117245
High expression of forkhead box M1 (FOXM1) is a poor prognostic biomarker in lung adenocarcinoma. PMID:35117241
Systemic characterization of the SLC family genes reveals SLC26A6 as a novel oncogene in hepatocellular carcinoma. PMID:35116598
Bioinformatic analysis of PLOD family member expression and prognostic value in non-small cell lung cancer. PMID:35116582
PUM1 is upregulated by DNA methylation to suppress antitumor immunity and results in poor prognosis in pancreatic cancer. PMID:35116535
Low expression of AQP9 and its value in hepatocellular carcinoma. PMID:35116505
A rare multiple primary sarcomatoid carcinoma (SCA) of small intestine harboring driver gene mutations: a case report and a literature review. PMID:35116442
Expression of CDK7 correlates with molecular subtypes and predicts clinical outcomes in breast cancer. PMID:35116400
Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer. PMID:35116394
A pan-cancer analysis of the oncogenic role of Keratin 17 (KRT17) in human tumors. PMID:35116305
The role of TRIM51 as a multipurpose biomarker in melanoma. PMID:35116291
Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis. PMID:35115556
Molecular Subtyping Resource: a user-friendly tool for rapid biological discovery from transcriptional data. PMID:35112706
SPARCL1 Is a Novel Prognostic Biomarker and Correlates with Tumor Microenvironment in Colorectal Cancer. PMID:35111844
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation. PMID:35105861
Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer. PMID:35105671
The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression. PMID:35102251
A novel long non-coding RNA regulates the integrin, ITGA2 in breast cancer. PMID:35098437
Malignant solitary fibrous tumor in the central nervous system treated with surgery, radiotherapy and anlotinib: A case report. PMID:35097089
In-Silico Multi-Omics Analysis of the Functional Significance of Calmodulin 1 in Multiple Cancers. PMID:35096010
LINC00467 Is Upregulated by DNA Copy Number Amplification and Hypomethylation and Shows ceRNA Potential in Lung Adenocarcinoma. PMID:35095769
Using Optical Tweezers to Dissect Allosteric Communication Networks in Protein Kinases. PMID:35094342
The oncogenic role of treacle ribosome biogenesis factor 1 (TCOF1) in human tumors: a pan-cancer analysis. PMID:35093935
Rho GTPase gene expression and breast cancer risk: a Mendelian randomization analysis. PMID:35087170
Proteomic profiling of cisplatin-resistant and cisplatin-sensitive germ cell tumour cell lines using quantitative mass spectrometry. PMID:35084545
Evidence for shared genetic risk factors between lymphangioleiomyomatosis and pulmonary function. PMID:35083324
The Age-Specific Features and Clinical Significance of NRF2 and MAPK10 Expression in HCC Patients. PMID:35082522
Modeling Androgen Deprivation Therapy-Induced Prostate Cancer Dormancy and Its Clinical Implications. PMID:35082166
KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas. PMID:35081118
Let's talk about sex: A biological variable in immune response against melanoma. PMID:35076986
Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT. PMID:35075245
Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations. PMID:35075200
Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer. PMID:35075123
A comprehensive characterization of the transcriptome in enzalutamide resistance prostate cancer. PMID:35071476
Genomic Profiling of Chinese Cervical Cancer Patients Reveals Prevalence of DNA Damage Repair Gene Alterations and Related Hypoxia Feature. PMID:35071000
Comprehensive Analysis of Copy Number Variation, Nucleotide Mutation, and Transcription Level of PPAR Pathway-Related Genes in Endometrial Cancer. PMID:35069712
Insights Into the Prognostic Value and Immunological Role of NAAA in Pan-Cancer. PMID:35069601
Classification of bladder cancer cell lines according to regulon activity. PMID:35068946
High expression of PDZ-binding kinase is correlated with poor prognosis and immune infiltrates in hepatocellular carcinoma. PMID:35065633
Characterization of Epigenomic Alterations in HPV16+ Head and Neck Squamous Cell Carcinomas. PMID:35064062
Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma. PMID:35062934
Bioinformatics analysis of recurrent deletion regions in neuroblastoma. PMID:35059899
Prognostic Value and Immune Infiltration Analysis of Nuclear Factor Erythroid-2 Family Members in Ovarian Cancer. PMID:35059466
Histological and molecular plasticity of ALK-positive non-small-cell lung cancer under targeted therapy: a case report. PMID:35058282
EGFR Exon 20 Insertion Mutations in Sinonasal Squamous Cell Carcinoma. PMID:35053553
High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients. PMID:35053500
Increased Expression and Altered Cellular Localization of Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Are Associated with Prostate Cancer Progression. PMID:35053442
Genetic Alterations in Mitochondrial DNA Are Complementary to Nuclear DNA Mutations in Pheochromocytomas. PMID:35053433
Onco-miR-21 Promotes Stat3-Dependent Gastric Cancer Progression. PMID:35053428
Decode the Stable Cell Communications Based on Neuropeptide-Receptors Network in 36746 Tumor Cells. PMID:35052689
The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors. PMID:35049682
Downregulation of m6 A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness. PMID:35048498
The dominant TP53 hotspot mutation in IDH -mutant astrocytoma, R273C, has distinctive pathologic features and sex-specific prognostic implications. PMID:35047821
Expression of TIMPs and MMPs in Ovarian Tumors, Ascites, Ascites-Derived Cells, and Cancer Cell Lines: Characteristic Modulatory Response Before and After Chemotherapy Treatment. PMID:35047406
Comprehensive Analysis of Prognostic Value and Immune Infiltration of the NT5DC Family in Hepatocellular Carcinoma. PMID:35047040
The path to the clinic: a comprehensive review on direct KRASG12C inhibitors. PMID:35045886
Enhancing Radioiodine Incorporation in BRAF-Mutant, Radioiodine-Refractory Thyroid Cancers with Vemurafenib and the Anti-ErbB3 Monoclonal Antibody CDX-3379: Results of a Pilot Clinical Trial. PMID:35045748
Primary tumour immune response and lymph node yields in colon cancer. PMID:35043009
Primary lung cancer in women after previous breast cancer. PMID:35040941
Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer. PMID:35040374
MiR-378a inhibits glucose metabolism by suppressing GLUT1 in prostate cancer. PMID:35039635
Integration of tumour sequencing and case-control data to assess pathogenicity of RAD51C missense variants in familial breast cancer. PMID:35039523
The initial expression alterations occurring to transcription factors during the formation of breast cancer: Evidence from bioinformatics. PMID:35037412
Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover. PMID:35033184
Core promoter mutation contributes to abnormal gene expression in bladder cancer. PMID:35033028
Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomarker. PMID:35033016
The modifying enzyme Tsr3 establishes the hierarchy of Rio kinase binding in 40S ribosome assembly. PMID:35031584
Calcium selective channel TRPV6: Structure, function, and implications in health and disease. PMID:35031425
How can same-gene mutations promote both cancer and developmental disorders? PMID:35030014
Promising novel biomarkers and candidate small-molecule drugs for lung adenocarcinoma: Evidence from bioinformatics analysis of high-throughput data. PMID:35028418
HBXIP induces anoikis resistance by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis and stabilize Prdx1 in breast cancer. PMID:35027562
USP15 and USP4 facilitate lung cancer cell proliferation by regulating the alternative splicing of SRSF1. PMID:35027535
The clinicopathological and molecular characteristics of resected EGFR-mutant lung adenocarcinoma. PMID:35023616
Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma. PMID:35022408
Low RUFY3 expression level is associated with lymph node metastasis in older women with invasive breast cancer. PMID:35018543
Truncating CDKN1A mutations: an insight into the biology of urinary tract carcinomas? PMID:35018253
Galectin-8, cytokines, and the storm. PMID:35015084
Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment. PMID:35013322
Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast. PMID:35013309
Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer. PMID:35013121
PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer. PMID:35013112
Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer. PMID:35012444
Neurofibromatosis Type 1 Gene Alterations Define Specific Features of a Subset of Glioblastomas. PMID:35008787
A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members. PMID:35008511
Secretory Autophagy Forges a Therapy Resistant Microenvironment in Melanoma. PMID:35008395
FoxO3a Inhibits Tamoxifen-Resistant Breast Cancer Progression by Inducing Integrin α5 Expression. PMID:35008379
Bak and Bcl-xL Participate in Regulating Sensitivity of Solid Tumor Derived Cell Lines to Mcl-1 Inhibitors. PMID:35008345
Role of novel cancer gene SLITRK3 to activate NTRK3 in squamous cell lung cancer. PMID:35006496
Integrated bioinformatics and experiments reveal the roles and driving forces for HSF1 in colorectal cancer. PMID:35006040
High Expression of Glycolytic Genes in Clinical Glioblastoma Patients Correlates With Lower Survival. PMID:35004842
CDKN2A Deletion Leading to Hematogenous Metastasis of Human Gastric Carcinoma. PMID:35004325
The mechanism of Raf activation through dimerization. PMID:35003591
Comprehensive Analyses of the Expression, Genetic Alteration, Prognosis Significance, and Interaction Networks of m6A Regulators Across Human Cancers. PMID:35003212
Systematic Pan-Cancer Analysis of KIF23 and a Prediction Model Based on KIF23 in Clear Cell Renal Cell Carcinoma (ccRCC). PMID:35002290
oCEM: Automatic detection and analysis of overlapping co-expressed gene modules. PMID:34998362
Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights. PMID:34996497
Identifying and Validating an Acidosis-Related Signature Associated with Prognosis and Tumor Immune Infiltration Characteristics in Pancreatic Carcinoma. PMID:34993253
Identification of high protein kinase CK2α in HPV(+) oropharyngeal squamous cell carcinoma and correlation with clinical outcomes. PMID:34993017
MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling. PMID:34992146
Development and validation of the new HER2DX assay for predicting pathological response and survival outcome in early-stage HER2-positive breast cancer. PMID:34990895
Metabolite profiling reveals a connection between aldehyde dehydrogenase 1A3 and GABA metabolism in breast cancer metastasis. PMID:34989902
POU2F3 beyond thymic carcinomas: expression across the spectrum of thymomas hints to medullary differentiation in type A thymoma. PMID:34988657
Characterization of the consensus mucosal microbiome of colorectal cancer. PMID:34988460
The Identification of Prognostic and Metastatic Alternative Splicing in Skin Cutaneous Melanoma. PMID:34986671
Overexpression of the PPAR-γ protein in primary Ta/T1 non-muscle-invasive urothelial carcinoma. PMID:34984103
Retinoblastoma protein regulates carcinogen susceptibility at heterochromatic cancer driver loci. PMID:34983823
KRAS Mutations in Squamous Cell Carcinomas of the Lung. PMID:34976827
FNDC3B and BPGM Are Involved in Human Papillomavirus-Mediated Carcinogenesis of Cervical Cancer. PMID:34976823
RNA-binding protein MEX3A controls G1/S transition via regulating the RB/E2F pathway in clear cell renal cell carcinoma. PMID:34976441
rAAV-delivered PTEN therapeutics for prostate cancer. PMID:34976432
Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway. PMID:34975329
Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis. PMID:34973624
Glycogenes in Oncofetal Chondroitin Sulfate Biosynthesis are Differently Expressed and Correlated With Immune Response in Placenta and Colorectal Cancer. PMID:34966741
P4HA1, a Prognostic Biomarker that Correlates With Immune Infiltrates in Lung Adenocarcinoma and Pan-Cancer. PMID:34966739
Splicing Factor DDX23, Transcriptionally Activated by E2F1, Promotes Ovarian Cancer Progression by Regulating FOXM1. PMID:34966670
Identification of the 7-lncRNA Signature as a Prognostic Biomarker for Acute Myeloid Leukemia. PMID:34966465
High Expression of CEMIP Correlates Poor Prognosis and the Tumur Microenvironment in Breast Cancer as a Promisingly Prognostic Biomarker. PMID:34966410
ESR1 hotspot mutations in endometrial stromal sarcoma with high-grade transformation and endocrine treatment. PMID:34961764
Myosin 1b promotes migration, invasion and glycolysis in cervical cancer via ERK/HIF-1α pathway. PMID:34956471
LINC00467, Driven by Copy Number Amplification and DNA Demethylation, Is Associated with Oxidative Lipid Metabolism and Immune Infiltration in Breast Cancer. PMID:34956437
p53 Immunohistochemistry Patterns Are Surrogate Biomarkers for TP53 Mutations in Gastrointestinal Neuroendocrine Neoplasms. PMID:34956360
Genomic analyses of the metastasis-derived prostate cancer cell lines LNCaP, VCaP, and PC3-AR. PMID:34951700
KDM6 Demethylases and Their Roles in Human Cancers. PMID:34950587
High Frequency of Juxtamembrane Domain ERBB2 Mutation in Gastric Cancer. PMID:34949663
MicroRNAs Regulate Cell Cycle and Cell Death Pathways in Glioblastoma. PMID:34948346
Nuclear RNA Exosome and Pervasive Transcription: Dual Sculptors of Genome Function. PMID:34948199
Pharmacological Inhibition of Sonic Hedgehog Signaling Suppresses Tumor Development in a Murine Model of Intrahepatic Cholangiocarcinoma. PMID:34948011
µ-Crystallin Is Associated with Disease Outcome in Head and Neck Squamous Cell Carcinoma. PMID:34945802
Insights of RKIP-Derived Suppression of Prostate Cancer. PMID:34945007
Carnitine Palmitoyltransferase 1 Regulates Prostate Cancer Growth under Hypoxia. PMID:34944922
Transcription Regulation and Genome Rewiring Governing Sensitivity and Resistance to FOXM1 Inhibition in Breast Cancer. PMID:34944900
YB1 Is a Major Contributor to Health Disparities in Triple Negative Breast Cancer. PMID:34944882
Rapid Androgen-Responsive Proteome Is Involved in Prostate Cancer Progression. PMID:34944692
Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases. PMID:34944522
Exploring the Value of BRD9 as a Biomarker, Therapeutic Target and Co-Target in Prostate Cancer. PMID:34944438
Targeting Chondroitin Sulfate Reduces Invasiveness of Glioma Cells by Suppressing CD44 and Integrin β1 Expression. PMID:34944101
TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in Triple-Negative Breast Cancer. PMID:34943938
Association between Altered Oncogenic Signaling Pathways and Overall Survival of Patients with Metastatic Colorectal Cancer. PMID:34943546
Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis. PMID:34941867
Expression and Clinical Significance of Novel Long Noncoding RNA Fibroblast Growth Factor 10AS and FGF10 in Colorectal Cancer. PMID:34939760
KDM4B promotes acute myeloid leukemia associated with AML1-ETO by regulating chromatin accessibility. PMID:34938963
Prognostic biomarker SMARCC1 and its association with immune infiltrates in hepatocellular carcinoma. PMID:34937564
High miR-3609 expression is associated with better prognosis in TNBC based on mining using systematic integrated public sequencing data. PMID:34934431
Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer. PMID:34933180
FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer. PMID:34932854
The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells. PMID:34930366
Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer. PMID:34930255
cbpManager: a web application to streamline the integration of clinical and genomic data in cBioPortal to support the Molecular Tumor Board. PMID:34930224
Comprehensive Analysis of Aldehyde Dehydrogenases (ALDHs) and Its Significant Role in Hepatocellular Carcinoma. PMID:34928471
KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis. PMID:34925656
Identification and Validation of a Novel Pyroptosis-Related Gene Signature for Prognosis Prediction in Soft Tissue Sarcoma. PMID:34925457
Prognostic Implications and Immune Infiltration Analysis of ALDOA in Lung Adenocarcinoma. PMID:34925439
The Systematic Landscape of Nectin Family and Nectin-Like Molecules: Functions and Prognostic Value in Low Grade Glioma. PMID:34925438
A Pan-Cancer Analysis of the Oncogenic Role of Integrin Beta4 (ITGB4) in Human Tumors. PMID:34924769
Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation. PMID:34922480
Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis. PMID:34921158
KRAS mutation-independent downregulation of MAPK/PI3K signaling in colorectal cancer. PMID:34919787
Cancer-derived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart. PMID:34918105
Changes in gene-gene interactions associated with cancer onset and progression are largely independent of changes in gene expression. PMID:34917899
Identifying a Hypoxia-Related Long Non-Coding RNAs Signature to Improve the Prediction of Prognosis and Immunotherapy Response in Hepatocellular Carcinoma. PMID:34917132
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. PMID:34910928
Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach. PMID:34910921
Epidermal Integrin α3β1 Regulates Tumor-Derived Proteases BMP-1, Matrix Metalloprotease-9, and Matrix Metalloprotease-3. PMID:34909716
Integrative analysis reveals methylenetetrahydrofolate dehydrogenase 1-like as an independent shared diagnostic and prognostic biomarker in five different human cancers. PMID:34908119
Heterogeneity of non-alcoholic fatty liver disease: Implications for clinical practice and research activity. PMID:34904031
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response. PMID:34903738
LRMP Associates With Immune Infiltrates and Acts as a Prognostic Biomarker in Lung Adenocarcinoma. PMID:34901148
Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics. PMID:34900668
A Network-Centric Framework for the Evaluation of Mutual Exclusivity Tests on Cancer Drivers. PMID:34899838
KRAS signaling in malignant pleural mesothelioma. PMID:34898002
BoxCar and shotgun proteomic analyses reveal molecular networks regulated by UBR5 in prostate cancer. PMID:34897998
High Expression of VAV Gene Family Predicts Poor Prognosis of Acute Myeloid Leukemia. PMID:34894858
MLL4 mediates differentiation and tumor suppression through ferroptosis. PMID:34890228
The Use of Machine Learning to Create a Risk Score to Predict Survival in Patients with Hepatocellular Carcinoma: A TCGA Cohort Analysis. PMID:34888264
A Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF1. PMID:34888238
S100A2 Is a Prognostic Biomarker Involved in Immune Infiltration and Predict Immunotherapy Response in Pancreatic Cancer. PMID:34887861
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1. PMID:34887559
NF-Y subunits overexpression in gastric adenocarcinomas (STAD). PMID:34887475
Sensitizing tumors to anti-PD-1 therapy by promoting NK and CD8+ T cells via pharmacological activation of FOXO3. PMID:34887262
Mismatch Repair Deficiency and Somatic Mutations in Human Sinonasal Tumors. PMID:34885191
An Observational Study on the Molecular Profiling of Primary Melanomas Reveals a Progression Dependence on Mitochondrial Activation. PMID:34885173
Histopathological and Molecular Profiling of Clear Cell Sarcoma and Correlation with Response to Crizotinib: An Exploratory Study Related to EORTC 90101 "CREATE" Trial. PMID:34885165
Pathogen-Induced Epigenetic Modifications in Cancers: Implications for Prevention, Detection and Treatment of Cancers in Africa. PMID:34885162
Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma. PMID:34885146
Stromal Cells Promote Matrix Deposition, Remodelling and an Immunosuppressive Tumour Microenvironment in a 3D Model of Colon Cancer. PMID:34885111
Gene Expression in Barrett's Esophagus Cell Lines Resemble Esophageal Squamous Cell Carcinoma Instead of Esophageal Adenocarcinoma. PMID:34885081
RAP1/TERF2IP-A Multifunctional Player in Cancer Development. PMID:34885080
DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review. PMID:34884835
Targeting Oncogenic Transcriptional Networks in Neuroblastoma: From N-Myc to Epigenetic Drugs. PMID:34884690
Molecular Determinants and Specificity of mRNA with Alternatively-Spliced UPF1 Isoforms, Influenced by an Insertion in the 'Regulatory Loop'. PMID:34884553
Hypomethylation-driven AKT Serine/Threonine Kinase 3 promotes testicular germ cell tumors proliferation and negatively correlates to immune infiltration. PMID:34882061
PRRC2A Promotes Hepatocellular Carcinoma Progression and Associates with Immune Infiltration. PMID:34881207
Computational analysis of cancer genome sequencing data. PMID:34880424
SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects. PMID:34879275
Landscape of the oncogenic role of fatty acid synthase in human tumors. PMID:34879004
Comprehensive Analysis of LPCATs Highlights the Prognostic and Immunological Values of LPCAT1/4 in Hepatocellular Carcinoma. PMID:34876845
Characterization of the GATA Transcription Factor Family and Exploration of Their Relevance to Immune Infiltration and Tumor Microenvironment in Pancreatic Cancer. PMID:34876843
A computational approach for the discovery of significant cancer genes by weighted mutation and asymmetric spreading strength in networks. PMID:34876593
Branching clonal evolution patterns predominate mutational landscape in multiple myeloma. PMID:34873486
A radiogenomics application for prognostic profiling of endometrial cancer. PMID:34873276
Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells. PMID:34871413
Development of a 15-Gene Signature Model as a Prognostic Tool in Sex Hormone-Dependent Cancers. PMID:34869761
Deciphering CHFR Role in Pancreatic Ductal Adenocarcinoma. PMID:34869418
Comprehensive Analysis and Identification of Prognostic Biomarkers and Therapeutic Targets Among FAM83 Family Members for Gastric Cancer. PMID:34869310
OLFML2B Is a Robust Prognostic Biomarker in Bladder Cancer Through Genome-Wide Screening: A Study Based on Seven Cohorts. PMID:34868901
Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma. PMID:34863298
From biobank and data silos into a data commons: convergence to support translational medicine. PMID:34863191
The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis. PMID:34863151
Association of PTPRT mutations with immune checkpoint inhibitors response and outcome in melanoma and non-small cell lung cancer. PMID:34862763
Targeting cancer metabolism in the era of precision oncology. PMID:34862480
Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML. PMID:34862459
Chromosome Missegregation as a Modulator of Radiation Sensitivity. PMID:34861996
Impact of TP53 Genomic Alterations in Large B-Cell Lymphoma Treated With CD19-Chimeric Antigen Receptor T-Cell Therapy. PMID:34860572
Multiomics profiling of the expression and prognosis of MCMs in endometrial carcinoma. PMID:34859821
An Integrative Pan-Cancer Analysis of PBK in Human Tumors. PMID:34859049
Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis. PMID:34858987
Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC. PMID:34858826
Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis. PMID:34858730
PPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer. PMID:34858479
Clinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine. PMID:34858045
miR-17 acts as a tumor suppressor by negatively regulating the miR-17-92 cluster. PMID:34853714
Emergence of mTOR mutation as an acquired resistance mechanism to AKT inhibition, and subsequent response to mTORC1/2 inhibition. PMID:34853384
The prognostic value of TPM1-4 in hepatocellular carcinoma. PMID:34850589
Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers. PMID:34849607
Real-World Approach for Molecular Analysis of Acquired EGFR Tyrosine Kinase Inhibitor Resistance Mechanisms in NSCLC. PMID:34849493
Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model. PMID:34849464
SKA3 Serves as a Biomarker for Poor Prognosis in Kidney Renal Papillary Cell Carcinoma. PMID:34849004
In vivo optical imaging-guided targeted sampling for precise diagnosis and molecular pathology. PMID:34848749
Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma. PMID:34848557
Molecular, clinical, and prognostic implications of PTPN11 mutations in acute myeloid leukemia. PMID:34847232
Genetic and epigenetic regulation of the NRF2-KEAP1 pathway in human lung cancer. PMID:34845361
Selective KRAS G12C inhibitors in non-small cell lung cancer: chemistry, concurrent pathway alterations, and clinical outcomes. PMID:34845311
The NUCKS1-SKP2-p21/p27 axis controls S phase entry. PMID:34845229
Prognostic and Immunological Significance of CXCR2 in Ovarian Cancer: A Promising Target for Survival Outcome and Immunotherapeutic Response Assessment. PMID:34840630
Prognostic Value Estimation of BRIP1 in Breast Cancer by Exploiting Transcriptomics Data Through Bioinformatics Approaches. PMID:34840500
MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance. PMID:34839359
Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients. PMID:34839279
AZD4547 targets the FGFR/Akt/SOX2 axis to overcome paclitaxel resistance in head and neck cancer. PMID:34837170
Bioinformatics Analysis Identifies Precision Treatment with Paclitaxel for Hepatocellular Carcinoma Patients Harboring Mutant TP53 or Wild-Type CTNNB1 Gene. PMID:34834551
Reciprocal Regulation of Hippo and WBP2 Signalling-Implications in Cancer Therapy. PMID:34831354
Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer. PMID:34830941
Melanoma Immunotherapy and Precision Medicine in the Era of Tumor Micro-Tissue Engineering: Where Are We Now and Where Are We Going? PMID:34830940
Cyclin E1 in Murine and Human Liver Cancer: A Promising Target for Therapeutic Intervention during Tumour Progression. PMID:34830835
Integrated Multi-Omics Investigations of Metalloproteinases in Colon Cancer: Focus on MMP2 and MMP9. PMID:34830271
p130Cas Is Correlated with EREG Expression and a Prognostic Factor Depending on Colorectal Cancer Stage and Localization Reducing FOLFIRI Efficacy. PMID:34830244
Patient-Specific Modeling of Diffuse Large B-Cell Lymphoma. PMID:34829885
Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma. PMID:34829830
Identification of NSP3 (SH2D3C) as a Prognostic Biomarker of Tumor Progression and Immune Evasion for Lung Cancer and Evaluation of Organosulfur Compounds from Allium sativum L. as Therapeutic Candidates. PMID:34829812
RANK-C Expression Sensitizes ER-Negative, EGFR-Positive Breast Cancer Cells to EGFR-Tyrosine Kinase Inhibitors (TKIs). PMID:34828291
The Identification of RNA Modification Gene PUS7 as a Potential Biomarker of Ovarian Cancer. PMID:34827123
Identification of LIG1 and LIG3 as prognostic biomarkers in breast cancer. PMID:34825062
A ubiquitous disordered protein interaction module orchestrates transcription elongation. PMID:34822292
Efficacy of Targeted Inhibitors in Metastatic Lung Squamous Cell Carcinoma With EGFR or ALK Alterations. PMID:34820641
Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells. PMID:34820606
KRAS A146 Mutations Are Associated With Distinct Clinical Behavior in Patients With Colorectal Liver Metastases. PMID:34820593
Q-omics: Smart Software for Assisting Oncology and Cancer Research. PMID:34819397
Predicting master transcription factors from pan-cancer expression data. PMID:34818047
Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy. PMID:34815254
TMPRSS4 promotes cancer stem-like properties in prostate cancer cells through upregulation of SOX2 by SLUG and TWIST1. PMID:34809669
Mitotic Errors Promote Genomic Instability and Leukemia in a Novel Mouse Model of Fanconi Anemia. PMID:34804941
Comprehensive Analysis of m6A RNA Methylation Regulators in the Prognosis and Immune Microenvironment of Multiple Myeloma. PMID:34804925
Overexpressing IFITM family genes predict poor prognosis in kidney renal clear cell carcinoma. PMID:34804826
Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer. PMID:34804118
Comprehensive Analysis of m6A RNA Methylation Regulators and the Immune Microenvironment to Aid Immunotherapy in Pancreatic Cancer. PMID:34804059
Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma. PMID:34799547
Hsa-miR-21-3p associates with breast cancer patient survival and targets genes in tumor suppressive pathways. PMID:34797887
PANX1 is a potential prognostic biomarker associated with immune infiltration in pancreatic adenocarcinoma: A pan-cancer analysis. PMID:34796785
Role of FRG1 in predicting the overall survivability in cancers using multivariate based optimal model. PMID:34795329
ZNF76 predicts prognosis and response to platinum chemotherapy in human ovarian cancer. PMID:34793589
A computational in silico approach to predict high-risk coding and non-coding SNPs of human PLCG1 gene. PMID:34793541
SLC7A5 is linked to increased expression of genes related to proliferation and hypoxia in estrogen‑receptor‑positive breast cancer. PMID:34792178
The F-box protein, FBXO7, is required to maintain chromosome stability in humans. PMID:34791250
Low Expression of SLC7A11 Confers Drug Resistance and Worse Survival in Ovarian Cancer via Inhibition of Cell Autophagy as a Competing Endogenous RNA. PMID:34790572
Prognostic and immune infiltrates for the Chromobox (CBX) protein family in human pancreatic adenocarcinoma. PMID:34790394
Prediction and prognostic significance of ALOX12B and PACSIN1 expression in gastric cancer by genome-wide RNA expression and methylation analysis. PMID:34790376
A Cholesterol Homeostasis-Related Gene Signature Predicts Prognosis of Endometrial Cancer and Correlates With Immune Infiltration. PMID:34790227
RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination. PMID:34789768
Clinical and genomic features of SPOP-mutant prostate cancer. PMID:34783071
Discovery proteomics defines androgen-regulated glycoprotein networks in prostate cancer cells, as well as putative biomarkers of prostatic diseases. PMID:34782677
Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers. PMID:34782604
Genomic Alterations in Human Papillomavirus-Positive and -Negative Conjunctival Squamous Cell Carcinomas. PMID:34779821
Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma. PMID:34779417
Radioresistance of Human Cancers: Clinical Implications of Genetic Expression Signatures. PMID:34778082
Molecular Characterization of the Highest Risk Adult Patients With Acute Myeloid Leukemia (AML) Through Multi-Omics Clustering. PMID:34777485
Roles of HMGBs in Prognosis and Immunotherapy: A Pan-Cancer Analysis. PMID:34777483
CSNK2 in cancer: pathophysiology and translational applications. PMID:34773100
Mutant p53 elicits context-dependent pro-tumorigenic phenotypes. PMID:34773073
The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes. PMID:34772942
Papillary Thyroid Cancer Prognosis: An Evolving Field. PMID:34771729
Drug Repositioning Based on the Reversal of Gene Expression Signatures Identifies TOP2A as a Therapeutic Target for Rectal Cancer. PMID:34771654
Genomic Instability of Circulating Tumor DNA as a Prognostic Marker for Pancreatic Cancer Survival: A Prospective Cohort Study. PMID:34771630
Clinical Value of NGS Genomic Studies for Clinical Management of Pediatric and Young Adult Bone Sarcomas. PMID:34771600
Individualized Proteogenomics Reveals the Mutational Landscape of Melanoma Patients in Response to Immunotherapy. PMID:34771574
Elevated Level of Nerve Growth Factor (NGF) in Serum-Derived Exosomes Predicts Poor Survival in Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy. PMID:34771423
Relevance of BRAF Subcellular Localization and Its Interaction with KRAS and KIT Mutations in Skin Melanoma. PMID:34769348
The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors. PMID:34769213
Deciphering the Genomic Landscape and Pharmacological Profile of Uncommon Entities of Adult Rhabdomyosarcomas. PMID:34768995
Systematic Analysis of FASTK Gene Family Alterations in Cancer. PMID:34768773
Alternative polyadenylation: An untapped source for prostate cancer biomarkers and therapeutic targets? PMID:34765448
Different members of the APOBEC3 family of DNA mutators have opposing associations with the landscape of breast cancer. PMID:34765315
Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells. PMID:34764293
TAp63 regulates bone remodeling by modulating the expression of TNFRSF11B/Osteoprotegerin. PMID:34763601
Role of caveolin-1 as a biomarker for radiation resistance and tumor aggression in lung cancer. PMID:34762666
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype. PMID:34762647
The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi-omics study. PMID:34761566
A comprehensive analysis of prefoldins and their implication in cancer. PMID:34761191
The Clinical Significance and Immunization of MSMO1 in Cervical Squamous Cell Carcinoma Based on Bioinformatics Analysis. PMID:34759952
Characterization and prognostic value of LXR splice variants in triple-negative breast cancer. PMID:34755086
Functional drug-target-disease network analysis of gene-phenotype connectivity for curcumin in hepatocellular carcinoma. PMID:34754622
Narrative online guides for the interpretation of digital-pathology images and tissue-atlas data. PMID:34750536
YTH domain family: potential prognostic targets and immune-associated biomarkers in hepatocellular carcinoma. PMID:34747720
Genome Instability and Long Noncoding RNA Reveal Biomarkers for Immunotherapy and Prognosis and Novel Competing Endogenous RNA Mechanism in Colon Adenocarcinoma. PMID:34746134
Re-Identification of Patient Subgroups in Uveal Melanoma. PMID:34745953
Knockdown of LMTK3 in the Endometrioid Adenocarcinoma Cell Line Ishikawa: Inhibition of Growth and Estrogen Receptor α. PMID:34745935
Immunogenomic Landscape Analysis of Prognostic Immune-Related Genes in Hepatocellular Carcinoma. PMID:34745496
Ral GEF with the PH Domain and SH3 Binding Motif 1 Regulated by Splicing Factor Junction Plakoglobin and Pyrimidine Metabolism Are Prognostic in Uterine Carcinosarcoma. PMID:34745385
Recognition of DNA Methylation Molecular Features for Diagnosis and Prognosis in Gastric Cancer. PMID:34745226
ZWINT is a Promising Therapeutic Biomarker Associated with the Immune Microenvironment of Hepatocellular Carcinoma. PMID:34744456
Androgen deprivation‑induced OPHN1 amplification promotes castration‑resistant prostate cancer. PMID:34738630
CDCA7 Facilitates Tumor Progression by Directly Regulating CCNA2 Expression in Esophageal Squamous Cell Carcinoma. PMID:34737951
Tumor-Infiltrating Immune-Related Long Non-Coding RNAs Indicate Prognoses and Response to PD-1 Blockade in Head and Neck Squamous Cell Carcinoma. PMID:34737735
Significance of TEAD Family in Diagnosis, Prognosis and Immune Response for Ovarian Serous Carcinoma. PMID:34737608
Secreted indicators of androgen receptor activity in breast cancer pre-clinical models. PMID:34736512
A prognostic fibroblast-related risk signature in colorectal cancer. PMID:34735373
Effect of mesenchymal-epithelial transition amplification on immune microenvironment and efficacy of immune checkpoint inhibitors in patients with non-small cell lung cancer. PMID:34734027
Prognostic and tumor-immune infiltration cell signatures in tamoxifen-resistant breast cancers. PMID:34733726
Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3. PMID:34733461
Allele-specific genomic data elucidate the role of somatic gain and copy-number neutral loss of heterozygosity in cancer. PMID:34731645
Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. PMID:34731610
The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma. PMID:34731180
ParsVNN: parsimony visible neural networks for uncovering cancer-specific and drug-sensitive genes and pathways. PMID:34729476
CKS2 Overexpression Correlates with Prognosis and Immune Cell Infiltration in Lung Adenocarcinoma: A Comprehensive Study based on Bioinformatics and Experiments. PMID:34729099
Prognostic evaluation and immune infiltration analysis of five bioinformatic selected genes in hepatocellular carcinoma. PMID:34726341
A mixture model for signature discovery from sparse mutation data. PMID:34724984
Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing. PMID:34724198
SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values. PMID:34722629
Conditional ERK3 overexpression cooperates with PTEN deletion to promote lung adenocarcinoma formation in mice. PMID:34719109
ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition. PMID:34718742
RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs. PMID:34718714
EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers. PMID:34718348
T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma. PMID:34717036
The role of PI3'-lipid signalling in melanoma initiation, progression and maintenance. PMID:34717019
Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse. PMID:34716314
PRCC reduces the sensitivity of cancer cells to DNA damage by inhibiting JNK and ATM/ATR pathways and results in a poor prognosis in hepatocellular carcinoma. PMID:34715922
MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer. PMID:34712921
TNFSF13 Is a Novel Onco-Inflammatory Marker and Correlates With Immune Infiltration in Gliomas. PMID:34712225
Oncogene-mediated metabolic gene signature predicts breast cancer outcome. PMID:34711841
Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation. PMID:34711823
Analysing a Novel RNA-Binding-Protein-Related Prognostic Signature Highly Expressed in Breast Cancer. PMID:34707800
CD47 (Cluster of Differentiation 47). PMID:34707698
Multi-Omics Analysis Identified TMED2 as a Shared Potential Biomarker in Six Subtypes of Human Cancer. PMID:34707394
MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling. PMID:34706761
Combined analysis of PTEN, HER2, and hormone receptors status: remodeling breast cancer risk profiling. PMID:34706703
CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation. PMID:34706306
Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-β-catenin-driven M2 macrophage. PMID:34703882
Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers. PMID:34702252
PIM1 phosphorylation of the androgen receptor and 14-3-3 ζ regulates gene transcription in prostate cancer. PMID:34697370
Mechanism of activation and the rewired network: New drug design concepts. PMID:34693559
Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway. PMID:34693224
Integrated bioinformatics analyses of key genes involved in hepatocellular carcinoma immunosuppression. PMID:34691257
Identification of C3 and FN1 as potential biomarkers associated with progression and prognosis for clear cell renal cell carcinoma. PMID:34688260
Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma. PMID:34687603
Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction. PMID:34686865
NUAK Kinases: Brain-Ovary Axis. PMID:34685740
Prognostic Significance of Dysregulated Epigenomic and Chromatin Modifiers in Cervical Cancer. PMID:34685645
Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers. PMID:34685612
Distinct Clinical Impact and Biological Function of Angiopoietin and Angiopoietin-like Proteins in Human Breast Cancer. PMID:34685578
A Mathematical Model of Breast Tumor Progression Based on Immune Infiltration. PMID:34683171
Deregulation of N6-Methyladenosine RNA Modification and Its Erasers FTO/ALKBH5 among the Main Renal Cell Tumor Subtypes. PMID:34683137
Integrated Molecular Characterization to Reveal the Association between Kynurenine 3-Monooxygenase Expression and Tumorigenesis in Human Breast Cancers. PMID:34683090
Prognostic Value of Interleukin-32 Expression and Its Correlation with the Infiltration of Natural Killer Cells in Cutaneous Melanoma. PMID:34682815
The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells. PMID:34681917
Identification of Tumor Antigens in Ovarian Cancers Using Local and Circulating Tumor-Specific Antibodies. PMID:34681879
Molecular Targets and Promising Therapeutics of Triple-Negative Breast Cancer. PMID:34681231
The Intrinsically Disordered Region in the Human STN1 OB-Fold Domain Is Important for Protecting Genome Stability. PMID:34681076
Clinically Translatable Approaches of Inhibiting TGF-β to Target Cancer Stem Cells in TNBC. PMID:34680503
Expression Profile and Prognostic Value of Wnt Signaling Pathway Molecules in Colorectal Cancer. PMID:34680448
Landscape of Immune-Related Markers and Potential Therapeutic Targets in Soft Tissue Sarcoma. PMID:34680396
Precision Oncology of High-Grade Ovarian Cancer Defined through Targeted Sequencing. PMID:34680387
Altered Expression of Shorter p53 Family Isoforms Can Impact Melanoma Aggressiveness. PMID:34680379
Comprehensive Analysis of VEGFR2 Expression in HPV-Positive and -Negative OPSCC Reveals Differing VEGFR2 Expression Patterns. PMID:34680369
Molecular Signature Expands the Landscape of Driver Negative Thyroid Cancers. PMID:34680332
Prognostic Gene Signature for Squamous Cell Carcinoma with a Higher Risk for Treatment Failure and Accelerated MEK-ERK Pathway Activity. PMID:34680330
Brain and Breast Cancer Cells with PTEN Loss of Function Reveal Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Utilizing 3D Scaffolds and Aligned Microfiber Tracts. PMID:34680293
A Systems Approach to Interrogate Gene Expression Patterns in African American Men Presenting with Clinically Localized Prostate Cancer. PMID:34680291
EGFR Exon 20 Insertion in Metastatic Non-Small-Cell Lung Cancer: Survival and Clinical Efficacy of EGFR Tyrosine-Kinase Inhibitor and Chemotherapy. PMID:34680280
Frequent Epigenetic Inactivation of DIRAS-1 and DIRAS-2 Contributes to Chemo-Resistance in Gliomas. PMID:34680261
Luminescence complementation technology for the identification of MYC:TRRAP inhibitors. PMID:34676047
ATR inhibition reverses the resistance of homologous recombination deficient MGMTlow/MMRproficient cancer cells to temozolomide. PMID:34676045
The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor. PMID:34674701
Proteogenomics Reveals Perturbed Signaling Networks in Malignant Melanoma Cells Resistant to BRAF Inhibition. PMID:34673281
Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. PMID:34671754
Pan-Cancer Analysis of the Associations of TGFBI Expression With Prognosis and Immune Characteristics. PMID:34671645
Targeting Long Non-Coding RNA TTN-AS1 Suppresses Bladder Cancer Progression. PMID:34671381
Comprehensive landscape of the renin-angiotensin system in Pan-cancer: a potential downstream mediated mechanism of SARS-CoV-2. PMID:34671200
Ecdysoneless Protein Regulates Viral and Cellular mRNA Splicing to Promote Cervical Oncogenesis. PMID:34670863
Prognostic implications of epidermal and platelet-derived growth factor receptor alterations in 2 cohorts of IDHwt glioblastoma. PMID:34667950
Distinction of lymphoid and myeloid clonal hematopoiesis. PMID:34663986
The Effect of Smoking on the Immune Microenvironment and Immunogenicity and Its Relationship With the Prognosis of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer. PMID:34660603
Prognostic Value and Immunological Role of MORF4-Related Gene-Binding Protein in Human Cancers. PMID:34660575
Identification of Therapeutic Targets and Prognostic Biomarkers Among Integrin Subunits in the Skin Cutaneous Melanoma Microenvironment. PMID:34660316
MELK expression in breast cancer is associated with infiltration of immune cell and pathological compete response (pCR) after neoadjuvant chemotherapy. PMID:34659896
A prognostic score based on long-term survivor unique transcriptomic signatures predicts patient survival in pancreatic ductal adenocarcinoma. PMID:34659888
Serine/threonine-protein kinase 24 is an inhibitor of gastric cancer metastasis through suppressing CDH1 gene and enhancing stemness. PMID:34659887
Genomic profiling of DVL-1 and its nuclear role as a transcriptional regulator in triple negative breast cancer. PMID:34659647
Overexpression of P4HA1 associates with poor prognosis and promotes cell proliferation and metastasis of lung adenocarcinoma. PMID:34659558
Identification of Novel Biomarkers Related to Lung Squamous Cell Carcinoma Using Integrated Bioinformatics Analysis. PMID:34659450
Structure-function relationships explain CTCF zinc finger mutation phenotypes in cancer. PMID:34657170
M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way. PMID:34656164
Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation. PMID:34656143
EZH2 inhibition confers PIK3CA-driven lung tumors enhanced sensitivity to PI3K inhibition. PMID:34655667
C/EBPβ induces B-cell acute lymphoblastic leukemia and cooperates with BLNK mutations. PMID:34653294
Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma. PMID:34651586
The Expression Patterns and Prognostic Value of the Proteasome Activator Subunit Gene Family in Gastric Cancer Based on Integrated Analysis. PMID:34650966
Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers. PMID:34649609
Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma. PMID:34649520
The human GID complex engages two independent modules for substrate recruitment. PMID:34647674
Cancer gene mutation frequencies for the U.S. population. PMID:34645806
Stat1 confers sensitivity to radiation in cervical cancer cells by controlling Parp1 levels: a new perspective for Parp1 inhibition. PMID:34642300
Identification of prostate cancer specific methylation biomarkers from a multi-cancer analysis. PMID:34641790
MET Amplification in Non-Small Cell Lung Cancer (NSCLC)-A Consecutive Evaluation Using Next-Generation Sequencing (NGS) in a Real-World Setting. PMID:34638507
TBX2 Drives Neuroendocrine Prostate Cancer through Exosome-Mediated Repression of miR-200c-3p. PMID:34638504
Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity. PMID:34638503
Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate Cancer. PMID:34638338
Targeted Sequencing Revealed Distinct Mutational Profiles of Ocular and Extraocular Sebaceous Carcinomas. PMID:34638295
The Role of the Hedgehog Pathway in Cholangiocarcinoma. PMID:34638259
Overcoming Immunotherapy Resistance by Targeting the Tumor-Intrinsic NLRP3-HSP70 Signaling Axis. PMID:34638239
The Landscape of Transmembrane Protein Family Members in Head and Neck Cancers: Their Biological Role and Diagnostic Utility. PMID:34638224
Phosphorylation of CAP1 regulates lung cancer proliferation, migration, and invasion. PMID:34636991
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma. PMID:34636321
Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly. PMID:34635648
Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters. PMID:34631566
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis. PMID:34630336
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4. PMID:34628485
rPAC: Route based pathway analysis for cohorts of gene expression data sets. PMID:34628030
Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells. PMID:34626204
6q deletion is frequent but unrelated to patient prognosis in breast cancer. PMID:34625909
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms. PMID:34624218
Predicting endometrial cancer subtypes and molecular features from histopathology images using multi-resolution deep learning models. PMID:34622237
LncRNA RNA Component of Mitochondrial RNA-Processing Endoribonuclease Promotes AKT-Dependent Breast Cancer Growth and Migration by Trapping MicroRNA-206. PMID:34621748
mRNA Network: Solution for Tracking Chemotherapy Insensitivity in Small-Cell Lung Cancer. PMID:34621500
The role of ERBB4 mutations in the prognosis of advanced non-small cell lung cancer treated with immune checkpoint inhibitors. PMID:34620079
Molecular implications of HOX genes targeting multiple signaling pathways in cancer. PMID:34617205
CTHRC1 expression is a novel shared diagnostic and prognostic biomarker of survival in six different human cancer subtypes. PMID:34615943
Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squamous NSCLC. PMID:34615542
Targeted Therapy for BRAF Mutant Brain Tumors. PMID:34613491
Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers. PMID:34611484
Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway. PMID:34611298
Genomic characterization of rare molecular subclasses of hepatocellular carcinoma. PMID:34608257
Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors. PMID:34607897
Centrosome Aberrations as Drivers of Chromosomal Instability in Breast Cancer. PMID:34606589
SNX20AR/MiRNA-301a-3p/SNX20 Axis Associated With Cell Proliferation and Immune Infiltration in Lung Adenocarcinoma. PMID:34604311
Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review. PMID:34604242
Estrogen Receptor Is Expressed in Uveal Melanoma: A Potential Target for Therapy. PMID:34604204
Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis. PMID:34603386
Recognition of Tumor-Associated Antigens and Immune Subtypes in Glioma for mRNA Vaccine Development. PMID:34603319
Genetic evolution to tyrosine kinase inhibitory therapy in patients with EGFR-mutated non-small-cell lung cancer. PMID:34599295
Recurrence-associated gene signature in patients with stage I non-small-cell lung cancer. PMID:34599262
Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer. PMID:34596356
Identification of hub genes and candidate drugs in hepatocellular carcinoma by integrated bioinformatics analysis. PMID:34596112
AGTRAP Is a Prognostic Biomarker Correlated With Immune Infiltration in Hepatocellular Carcinoma. PMID:34595113
Genomic evidence suggests that cutaneous neuroendocrine carcinomas can arise from squamous dysplastic precursors. PMID:34593967
BAP1 methylation: a prognostic marker of uveal melanoma metastasis. PMID:34593944
Response to Immune Checkpoint Inhibition as Monotherapy or in Combination With Chemotherapy in Metastatic ROS1-Rearranged Lung Cancers. PMID:34590036
Genomic and Transcriptomic Characterization of Relapsed SCLC Through Rapid Research Autopsy. PMID:34590014
Structural determinants of peptide-dependent TAP1-TAP2 transit passage targeted by viral proteins and altered by cancer-associated mutations. PMID:34589184
MMP1 and MMP9 are potential prognostic biomarkers and targets for uveal melanoma. PMID:34587931
Pan-cancer analysis indicates that MYBL2 is associated with the prognosis and immunotherapy of multiple cancers as an oncogene. PMID:34585645
Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis. PMID:34585630
MXD3 as an onco-immunological biomarker encompassing the tumor microenvironment, disease staging, prognoses, and therapeutic responses in multiple cancer types. PMID:34584637
HNRNPC Promotes Proliferation, Metastasis and Predicts Prognosis in Prostate Cancer. PMID:34584453
Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation. PMID:34584219
Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer. PMID:34583980
Rational Combination of CRM1 Inhibitor Selinexor and Olaparib Shows Synergy in Ovarian Cancer Cell Lines and Mouse Models. PMID:34583979
MLL3 is a de novo cause of endocrine therapy resistance. PMID:34581028
Expanding the spectrum of thyroid carcinoma with somatic DICER1 mutation: a survey of 829 thyroid carcinomas using MSK-IMPACT next-generation sequencing platform. PMID:34580763
Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models. PMID:34576133
Analysis of SYK Gene as a Prognostic Biomarker and Suggested Potential Bioactive Phytochemicals as an Alternative Therapeutic Option for Colorectal Cancer: An In-Silico Pharmaco-Informatics Investigation. PMID:34575665
Epigenetic Silencing of HER2 Expression during Epithelial-Mesenchymal Transition Leads to Trastuzumab Resistance in Breast Cancer. PMID:34575017
Genetic Variants and Somatic Alterations Associated with MITF-E318K Germline Mutation in Melanoma Patients. PMID:34573422
Identifying New Potential Biomarkers in Adrenocortical Tumors Based on mRNA Expression Data Using Machine Learning. PMID:34572898
Elevating CDCA3 Levels Enhances Tyrosine Kinase Inhibitor Sensitivity in TKI-Resistant EGFR Mutant Non-Small-Cell Lung Cancer. PMID:34572879
Mutations in Epigenetic Regulation Genes in Gastric Cancer. PMID:34572812
The Role of p53 in Progression of Cutaneous Squamous Cell Carcinoma. PMID:34572732
A Preclinical Investigation of GBM-N019 as a Potential Inhibitor of Glioblastoma via Exosomal mTOR/CDK6/STAT3 Signaling. PMID:34572040
Plectin in Cancer: From Biomarker to Therapeutic Target. PMID:34571895
CEBPD Potentiates the Macrophage Inflammatory Response but CEBPD Knock-Out Macrophages Fail to Identify CEBPD-Dependent Pro-Inflammatory Transcriptional Programs. PMID:34571881
Metastatic Castration-Resistant Prostate Cancer Remains Dependent on Oncogenic Drivers Found in Primary Tumors. PMID:34568716
Aberrant DNA Methylation-Mediated FOXF2 Dysregulation Is a Prognostic Risk Factor for Gastric Cancer. PMID:34568422
Integrative Analysis of Biomarkers Through Machine Learning Identifies Stemness Features in Colorectal Cancer. PMID:34568334
The Role of Akt in Acquired Cetuximab Resistant Head and Neck Squamous Cell Carcinoma: An In Vitro Study on a Novel Combination Strategy. PMID:34568028
Chromobox Homolog 8 (CBX8) in Human Tumor Carcinogenesis and Prognosis: A Pancancer Analysis Using Multiple Databases. PMID:34567093
Smarca4 Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung. PMID:34561242
Identification of Novel Molecular Therapeutic Targets and Their Potential Prognostic Biomarkers Among Kinesin Superfamily of Proteins in Pancreatic Ductal Adenocarcinoma. PMID:34557409
Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner. PMID:34556788
Copy number alteration of the interferon gene cluster in cancer: Individual patient data meta-analysis prospects to personalized immunotherapy. PMID:34555656
RAF1 amplification drives a subset of bladder tumors and confers sensitivity to MAPK-directed therapeutics. PMID:34554931
Insulin and the insulin receptor collaborate to promote human gastric cancer. PMID:34554347
Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer. PMID:34554200
Single-cell profiling defines the prognostic benefit of CD39high tissue resident memory CD8+ T cells in luminal-like breast cancer. PMID:34552178
Predicting chemotherapy response using a variational autoencoder approach. PMID:34551729
Single-cell DNA and RNA sequencing reveals the dynamics of intra-tumor heterogeneity in a colorectal cancer model. PMID:34548081
Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents. PMID:34545188
The immunotherapy candidate TNFSF4 may help the induction of a promising immunological response in breast carcinomas. PMID:34545132
Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy. PMID:34545095
Identification of ARHGEF38, NETO2, GOLM1, and SAPCD2 Associated With Prostate Cancer Progression by Bioinformatic Analysis and Experimental Validation. PMID:34540835
Comprehensive Analysis of a Nine-Gene Signature Related to Tumor Microenvironment in Lung Adenocarcinoma. PMID:34540825
CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK-dependent signaling. PMID:34539851
A Pan-Cancer Analysis of the Prognostic Value and Expression of Adenylate Cyclase 7 (ADCY7) in Human Tumors. PMID:34539183
Shugosin 2 is a biomarker for pathological grading and survival prediction in patients with gliomas. PMID:34535705
Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer. PMID:34535676
An IDO1-related immune gene signature predicts overall survival in acute myeloid leukemia. PMID:34535017
A newly established monoclonal antibody against ERCC1 detects major isoforms of ERCC1 in gastric cancer. PMID:34532603
Increased RBM12 expression predicts poor prognosis in hepatocellular carcinoma based on bioinformatics. PMID:34532138
SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia. PMID:34531253
Genome-wide association studies of survival in 1520 cancer patients treated with bevacizumab-containing regimens. PMID:34528705
RNA-binding proteins of COSMIC importance in cancer. PMID:34523614
An Overview of the Genomic Characterization of Hepatocellular Carcinoma. PMID:34522690
bFGF-mediated phosphorylation of δ-catenin increases its protein stability and the ability to induce the nuclear redistribution of β-catenin. PMID:34522455
Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter. PMID:34520744
The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis. PMID:34520390
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids. PMID:34518665
Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression. PMID:34518527
Targeting Tumor-Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer. PMID:34518296
Integrative analysis reveals clinically relevant molecular fingerprints in pancreatic cancer. PMID:34513290
YTHDF2 is a Potential Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma. PMID:34512342
Pro-Oncogenic c-Met/EGFR, Biomarker Signatures of the Tumor Microenvironment are Clinical and Therapy Response Prognosticators in Colorectal Cancer, and Therapeutic Targets of 3-Phenyl-2H-benzo[e][1,3]-Oxazine-2,4(3H)-Dione Derivatives. PMID:34512327
Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer. PMID:34509979
Comprehensive characterization of somatic variants associated with intronic polyadenylation in human cancers. PMID:34508351
Proteogenomic analysis of pancreatic cancer subtypes. PMID:34506537
Signet ring cell cancer of stomach and gastro-esophageal junction: molecular alterations, stage-stratified treatment approaches, and future challenges. PMID:34505199
Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression. PMID:34505065
Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases. PMID:34505004
The Cancer Epitope Database and Analysis Resource: A Blueprint for the Establishment of a New Bioinformatics Resource for Use by the Cancer Immunology Community. PMID:34504503
Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity. PMID:34504076
Prognostic and Therapeutic Potential of the OIP5 Network in Papillary Renal Cell Carcinoma. PMID:34503297
Targeting CD82/KAI1 for Precision Therapeutics in Surmounting Metastatic Potential in Breast Cancer. PMID:34503296
Playing on the Dark Side: SMYD3 Acts as a Cancer Genome Keeper in Gastrointestinal Malignancies. PMID:34503239
TP53 in Biology and Treatment of Osteosarcoma. PMID:34503094
A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML. PMID:34502319
Unraveling the Relevance of ARL GTPases in Cutaneous Melanoma Prognosis through Integrated Bioinformatics Analysis. PMID:34502169
Zinc Favors Triple-Negative Breast Cancer's Microenvironment Modulation and Cell Plasticity. PMID:34502091
RNA binding motif 47 (RBM47): emerging roles in vertebrate development, RNA editing and cancer. PMID:34499322
Stress-activated kinases as therapeutic targets in pancreatic cancer. PMID:34497429
Dysregulated paired related homeobox 1 impacts on hepatocellular carcinoma phenotypes. PMID:34496784
Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity. PMID:34496233
Transcriptional analysis of the expression, prognostic value and immune infiltration activities of the COMMD protein family in hepatocellular carcinoma. PMID:34493238
Pan-Cancer Analysis Identified C1ORF112 as a Potential Biomarker for Multiple Tumor Types. PMID:34490347
Integrative Analysis of Minichromosome Maintenance Proteins and Their Prognostic Significance in Melanoma. PMID:34490114
Prognostic role of EGR1 in breast cancer: a systematic review. PMID:34488929
The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy. PMID:34488905
Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8. PMID:34488871
Carcinogenic effect of adenylosuccinate lyase (ADSL) in prostate cancer development and progression through the cell cycle pathway. PMID:34488772
Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis. PMID:34488675
Integrated analysis of Solute carrier family-2 members reveals SLC2A4 as an independent favorable prognostic biomarker for breast cancer. PMID:34488531
A pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers. PMID:34486492
Gene expression and prognosis of x-ray repair cross-complementing family members in non-small cell lung cancer. PMID:34486486
Zooming in on the WNT/CTNNB1 Destruction Complex: Functional Mechanistic Details with Implications for Therapeutic Targeting. PMID:34486095
Transcriptomic Analyses Reveal B-Cell Translocation Gene 2 as a Potential Therapeutic Target in Ovarian Cancer. PMID:34485119
Kinase fusion-related thyroid carcinomas: distinct pathologic entities with evolving diagnostic implications. PMID:34484420
Nicardipine Inhibits Breast Cancer Migration via Nrf2/HO-1 Axis and Matrix Metalloproteinase-9 Regulation. PMID:34483918
Cancer testis antigens and genomic instability: More than immunology. PMID:34481156
SAMHD1 in cancer: curse or cure? PMID:34480199
Telomeric zinc-finger associated protein (TZAP) in cancer biology: friend or foe? PMID:34476265
Overexpression of TMEFF1 in Endometrial Carcinoma and the Mechanism Underlying its Promotion of Malignant Behavior in Cancer Cells. PMID:34475991
The Alterations and Potential Roles of MCMs in Breast Cancer. PMID:34475953
Novel diagnostic and prognostic biomarkers of colorectal cancer: Capable to overcome the heterogeneity-specific barrier and valid for global applications. PMID:34473751
The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway. PMID:34471290
Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes. PMID:34470661
Virus-host interactions in carcinogenesis of Epstein-Barr virus-associated gastric carcinoma: Potential roles of lost ARID1A expression in its early stage. PMID:34469459
Integrative overview of IFITMs family based on Bioinformatics analysis. PMID:34466338
Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes. PMID:34465782
Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study. PMID:34464379
Systematic Analysis of Cytostatic TGF-Beta Response in Mesenchymal-Like Hepatocellular Carcinoma Cell Lines. PMID:34463913
Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients. PMID:34461927
Mnt Represses Epithelial Identity To Promote Epithelial-to-Mesenchymal Transition. PMID:34460331
Interferon-Induced Transmembrane Protein 3 Shapes an Inflamed Tumor Microenvironment and Identifies Immuno-Hot Tumors. PMID:34456915
MEX3D is an oncogenic driver in prostate cancer. PMID:34455614
Pan-cancer analysis of the oncogenic role of discs large homolog associated protein 5 (DLGAP5) in human tumors. PMID:34454476
SMAD4 is critical in suppression of BRAF-V600E serrated tumorigenesis. PMID:34453124
Ruthenium Complexes: An Alternative to Platinum Drugs in Colorectal Cancer Treatment. PMID:34452256
Genomic Profiling of Prostate Cancer: An Updated Review. PMID:34448375
Epigenetic Deregulation of the Histone Methyltransferase KMT5B Contributes to Malignant Transformation in Glioblastoma. PMID:34447744
Loss of ARID1A Promotes Hepatocellular Carcinoma Progression via Up-regulation of MYC Transcription. PMID:34447682
Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes. PMID:34446793
Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity. PMID:34446728
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer. PMID:34446716
Syndecan Family Gene and Protein Expression and Their Prognostic Values for Prostate Cancer. PMID:34445387
The SCF Complex Is Essential to Maintain Genome and Chromosome Stability. PMID:34445249
Multi-Omics Analysis of SOX4, SOX11, and SOX12 Expression and the Associated Pathways in Human Cancers. PMID:34442467
Unraveling the Epigenetic Role and Clinical Impact of Histone Deacetylases in Neoplasia. PMID:34441281
Association of TP53 Alteration with Tissue Specificity and Patient Outcome of IDH1-Mutant Glioma. PMID:34440884
Comprehensive Integrative Analysis Reveals the Association of KLF4 with Macrophage Infiltration and Polarization in Lung Cancer Microenvironment. PMID:34440860
Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer. PMID:34440533
Transcriptional Regulation of RUNX1: An Informatics Analysis. PMID:34440349
Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers. PMID:34440228
Non-Coding RNA-Based Biosensors for Early Detection of Liver Cancer. PMID:34440168
Predicting Agents That Can Overcome 5-FU Resistance in Colorectal Cancers via Pharmacogenomic Analysis. PMID:34440086
GNAi2/gip2-Regulated Transcriptome and Its Therapeutic Significance in Ovarian Cancer. PMID:34439877
Chromoanagenesis Landscape in 10,000 TCGA Patients. PMID:34439350
Pan-Cancer Analysis of Immune Complement Signature C3/C5/C3AR1/C5AR1 in Association with Tumor Immune Evasion and Therapy Resistance. PMID:34439277
EVI2B Is a New Prognostic Biomarker in Metastatic Melanoma with IFNgamma Associated Immune Infiltration. PMID:34439264
Hypoxic Jumbo Spheroids On-A-Chip (HOnAChip): Insights into Treatment Efficacy. PMID:34439199
3q26 Amplifications in Cervical Squamous Carcinomas. PMID:34436017
Small cell lung cancer transformation during antitumor therapies: A systematic review. PMID:34435141
Identification of a Costimulatory Molecule Gene Signature to Predict Survival and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma. PMID:34434928
A clinically applicable integrative molecular classification of meningiomas. PMID:34433969
Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma. PMID:34433873
How to Achieve Therapeutic Response in Erlotinib-Resistant Head and Neck Squamous Cell Carcinoma? New Insights from Stable Isotope Labeling with Amino Acids in Cell Culture-Based Quantitative Tyrosine Phosphoproteomics. PMID:34432535
Identification of GNA12-driven gene signatures and key signaling networks in ovarian cancer. PMID:34429759
Elevated mRNA Level of Y-Box Binding Protein 1 Indicates Unfavorable Prognosis Correlated with Macrophage Infiltration and T Cell Exhaustion in Luminal Breast Cancer. PMID:34429650
Mechanisms of targeted therapy resistance in a pediatric glioma driven by ETV6-NTRK3 fusion. PMID:34429303
SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia. PMID:34426610
IL6 and BCL3 Expression Are Potential Biomarkers in Esophageal Squamous Cell Carcinoma. PMID:34422669
DNA repair genes are associated with tumor tissue differentiation and immune environment in lung adenocarcinoma: a bioinformatics analysis based on big data. PMID:34422373
Basic Pan-Cancer Analysis of the Carcinogenic Effects of Cyclin-Dependent Kinase 4 (CDK4) in Human Surface Tumors. PMID:34422248
Predictive Value of the TP53/PIK3CA/ATM Mutation Classifier for Patients With Bladder Cancer Responding to Immune Checkpoint Inhibitor Therapy. PMID:34421886
BC-N102 suppress breast cancer tumorigenesis by interfering with cell cycle regulatory proteins and hormonal signaling, and induction of time-course arrest of cell cycle at G1/G0 phase. PMID:34421361
Effect of LAMA4 on Prognosis and Its Correlation with Immune Infiltration in Gastric Cancer. PMID:34414238
Two Similar Signatures for Predicting the Prognosis and Immunotherapy Efficacy of Stomach Adenocarcinoma Patients. PMID:34414187
DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma. PMID:34414037
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology. PMID:34413304
ATR Inhibitor M6620 (VX-970) Enhances the Effect of Radiation in Non-Small Cell Lung Cancer Brain Metastasis Patient-Derived Xenografts. PMID:34413128
Ten simple rules for creating reusable pathway models for computational analysis and visualization. PMID:34411100
YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer. PMID:34408926
Targeting AXL in NSCLC. PMID:34408519
Recurrent Human Papillomavirus-Related Head and Neck Cancer Undergoes Metabolic Reprogramming and Is Driven by Oxidative Phosphorylation. PMID:34407971
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice. PMID:34406363
Clinical, genetic and pharmacological data support targeting the MEK5/ERK5 module in lung cancer. PMID:34404896
ZNF768 links oncogenic RAS to cellular senescence. PMID:34404770
Bioinformatics analysis of the transcriptional expression of minichromosome maintenance proteins as potential indicators of survival in patients with cervical cancer. PMID:34404366
DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling. PMID:34399732
A novel treatment strategy for lapatinib resistance in a subset of HER2-amplified gastric cancer. PMID:34399705
Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls. PMID:34398495
Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database. PMID:34397798
Prognostic Prediction, Immune Microenvironment, and Drug Resistance Value of Collagen Type I Alpha 1 Chain: From Gastrointestinal Cancers to Pan-Cancer Analysis. PMID:34395525
Potential Role of SWI/SNF Complex Subunit Actin-Like Protein 6A in Cervical Cancer. PMID:34395295
Dissecting the biological heterogeneity of HER2-positive breast cancer. PMID:34392185
MEK inhibition overcomes resistance to EphA2-targeted therapy in uterine cancer. PMID:34391578
Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A. PMID:34390123
Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer. PMID:34389806
Genomic landscape of a mouse model of diffuse-type gastric adenocarcinoma. PMID:34387762
Polyfunctional KLRG-1+CD57+ Senescent CD4+ T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients. PMID:34386013
Prognostic and Immunological Role of Gasdermin E in Pan-Cancer Analysis. PMID:34381728
Comprehensive Analysis of the Expression Characteristics of the Enhancer of the Zeste Homolog 2 Gene in Pan-Cancer. PMID:34381492
Comprehensive Analysis of the Expression and Prognostic Value of SPINT1/2 in Breast Carcinoma. PMID:34381422
A merged microarray meta-dataset for transcriptionally profiling colorectal neoplasm formation and progression. PMID:34381057
A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis. PMID:34381052
Pan-Cancer Survival Classification With Clinicopathological and Targeted Gene Expression Features. PMID:34376966
The evolution of hematopoietic cells under cancer therapy. PMID:34376657
SWI/SNF complex alterations as a biomarker of immunotherapy efficacy in pancreatic cancer. PMID:34375311
Molecular Pathology of Urothelial Carcinoma. PMID:34373092
Evidence for AJUBA-catenin-CDH4-linked differentiation resistance of mesenchymal stem cells implies tumorigenesis and progression of head and neck squamous cell carcinoma: a single-cell transcriptome approach. PMID:34368804
Multi-Omics Integrative Bioinformatics Analyses Reveal Long Non-coding RNA Modulates Genomic Integrity via Competing Endogenous RNA Mechanism and Serves as Novel Biomarkers for Overall Survival in Lung Adenocarcinoma. PMID:34368141
Phosphoinositide Recognition Sites Are Blocked by Metabolite Attachment. PMID:34368138
Acylglycerol Kinase-Targeted Therapies in Oncology. PMID:34368119
PSMB7 Is a Key Gene Involved in the Development of Multiple Myeloma and Resistance to Bortezomib. PMID:34367968
Multi-Omic Analyses of the m5C Regulator ALYREF Reveal Its Essential Roles in Hepatocellular Carcinoma. PMID:34367948
E2F3 drives the epithelial-to-mesenchymal transition, cell invasion, and metastasis in breast cancer. PMID:34365840
Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting. PMID:34364401
Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis. PMID:34364391
hMOB2 deficiency impairs homologous recombination-mediated DNA repair and sensitises cancer cells to PARP inhibitors. PMID:34363951
Polymorphous Low-Grade Neuroepithelial Tumor of the Young (PLNTY): Molecular Profiling Confirms Frequent MAPK Pathway Activation. PMID:34363682
Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction. PMID:34362880
BCL7A as a novel prognostic biomarker for glioma patients. PMID:34362400
NF1-Dependent Transcriptome Regulation in the Melanocyte Lineage and in Melanoma. PMID:34362135
Tumor Promoting Effect of BMP Signaling in Endometrial Cancer. PMID:34360647
The Most Common VHL Point Mutation R167Q in Hereditary VHL Disease Interferes with Cell Plasticity Regulation. PMID:34359798
Glutamatergic Signaling a Therapeutic Vulnerability in Melanoma. PMID:34359771
The Role of DND1 in Cancers. PMID:34359581
Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer. PMID:34356885
Molecular and Pathological Profiling of Corresponding Treatment-Naïve and Neoadjuvant Pazopanib-Treated High-Risk Soft Tissue Sarcoma Samples of the GISG-04/NOPASS Study. PMID:34356494
Context-Dependent Roles of Claudins in Tumorigenesis. PMID:34354941
Increased apoptosis is associated with robust immune cell infiltration and cytolytic activity in breast cancer. PMID:34354867
A novel five-gene score to predict complete pathological response to neoadjuvant chemotherapy in ER-positive/HER2-negative breast cancer. PMID:34354863
Analyzing Roles of NUSAP1 From Clinical, Molecular Mechanism and Immune Perspectives in Hepatocellular Carcinoma. PMID:34354737
Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation. PMID:34352208
Pancreas cancer and BRCA: A critical subset of patients with improving therapeutic outcomes. PMID:34351646
Dual inhibition of FGFR4 and BCL-xL inhibits multi-resistant ovarian cancer with BCL2L1 gain. PMID:34351305
In silico assessment of EpCAM transcriptional expression and determination of the prognostic biomarker for human lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). PMID:34345719
Sensitivity to targeted therapy differs between HER2-amplified breast cancer cells harboring kinase and helical domain mutations in PIK3CA. PMID:34344439
Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study. PMID:34343214
Comprehensive characterization of pathological stage-related genes of papillary thyroid cancer along with survival prediction. PMID:34342109
Revisiting vimentin: a negative surrogate marker of molecularly defined oligodendroglioma in adult type diffuse glioma. PMID:34338912
Linking genome variants to disease: scalable approaches to test the functional impact of human mutations. PMID:34338757
A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. PMID:34337560
An Integrated Deep Network for Cancer Survival Prediction Using Omics Data. PMID:34337396
Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast Cancer. PMID:34336686
A Novel Five-Gene Signature for Prognosis Prediction in Hepatocellular Carcinoma. PMID:34336648
Identification and Validation of a Prognostic Signature for Prostate Cancer Based on Ferroptosis-Related Genes. PMID:34336641
Significant Diagnostic and Prognostic Value of FLAD1 and Related MicroRNAs in Breast Cancer after a Pan-Cancer Analysis. PMID:34336008
Snail1 expression in endothelial cells controls growth, angiogenesis and differentiation of breast tumors. PMID:34335957
Integrative Bioinformatics Study of Tangeretin Potential Targets for Preventing Metastatic Breast Cancer. PMID:34335799
Comprehensive Analysis of the Value of SMYD Family Members in the Prognosis and Immune Infiltration of Malignant Digestive System Tumors. PMID:34335697
SIRT4 and SIRT6 Serve as Novel Prognostic Biomarkers With Competitive Functions in Serous Ovarian Cancer. PMID:34335684
Nucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma. PMID:34334108
Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer. PMID:34329194
Lung adenocarcinoma patients with KEAP1 mutation harboring low immune cell infiltration and low activity of immune environment. PMID:34328274
Glycoprotein non-metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation. PMID:34327762
A Comprehensive Pan-Cancer Analysis of RBM8A Based on Data Mining. PMID:34326876
RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway. PMID:34326698
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer. PMID:34326322
Germ-line mutations in WDR77 predispose to familial papillary thyroid cancer. PMID:34326253
Activation of the ABCB1 Amplicon in Docetaxel- and Cabazitaxel-Resistant Prostate Cancer Cells. PMID:34326198
UCSCXenaShiny: An R/CRAN Package for Interactive Analysis of UCSC Xena Data. PMID:34323947
Pan-Cancer Prognostic Role and Targeting Potential of the Estrogen-Progesterone Axis. PMID:34322374
Bioinformatics Analysis of KIF1A Expression and Gene Regulation Network in Ovarian Carcinoma. PMID:34321916
The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core. PMID:34316696
PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer. PMID:34315821
Construction of a novel mRNA-signature prediction model for prognosis of bladder cancer based on a statistical analysis. PMID:34315402
The role of YTH domain containing 2 in epigenetic modification and immune infiltration of pan-cancer. PMID:34312987
RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer. PMID:34312180
Functional impact of cancer patient-associated Bcl-xL mutations. PMID:34308416
Pan-Cancer Survey of Tumor Mass Dormancy and Underlying Mutational Processes. PMID:34307377
Transcriptomic Analysis Identified ARHGAP Family as a Novel Biomarker Associated With Tumor-Promoting Immune Infiltration and Nanomechanical Characteristics in Bladder Cancer. PMID:34307347
Expression and Clinical Significance of Lactate Dehydrogenase A in Colon Adenocarcinoma. PMID:34307169
Identification of Predictive Biomarkers for Lymph Node Involvement in Obese Women With Endometrial Cancer. PMID:34307159
Genomic alterations and possible druggable mutations in carcinoma of unknown primary (CUP). PMID:34302033
AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B. PMID:34301793
Targeting EGFR Exon 20 Insertions in Non-Small Cell Lung Cancer: Recent Advances and Clinical Updates. PMID:34301786
SPTAN1 Expression Predicts Treatment and Survival Outcomes in Colorectal Cancer. PMID:34298848
Tetranucleotide and Low Microsatellite Instability Are Inversely Associated with the CpG Island Methylator Phenotype in Colorectal Cancer. PMID:34298744
Explainable Artificial Intelligence Reveals Novel Insight into Tumor Microenvironment Conditions Linked with Better Prognosis in Patients with Breast Cancer. PMID:34298668
Methyltransferases in the Pathogenesis of Keratinocyte Cancers. PMID:34298617
circExp database: an online transcriptome platform for human circRNA expressions in cancers. PMID:34296749
KiRNet: Kinase-centered network propagation of pharmacological screen results. PMID:34296206
NEK7 Promotes Pancreatic Cancer Progression And Its Expression Is Correlated With Poor Prognosis. PMID:34295827
De novo and cell line models of human mammary cell transformation reveal an essential role for Yb-1 in multiple stages of human breast cancer. PMID:34294889
Expression patterns and prognostic value of RUNX genes in kidney cancer. PMID:34294773
The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas. PMID:34293822
Collagen XVII inhibits breast cancer cell proliferation and growth through deactivation of the AKT/mTOR signaling pathway. PMID:34293053
Autocrine signaling by receptor tyrosine kinases in urothelial carcinoma of the bladder. PMID:34292953
Liver-Metastasis-Related Genes are Potential Biomarkers for Predicting the Clinical Outcomes of Patients with Pancreatic Adenocarcinoma. PMID:34290570
Preoperative clinical and tumor genomic features associated with pathologic lymph node metastasis in clinical stage I and II lung adenocarcinoma. PMID:34290393
Identification of prognostic long non-coding RNA signature with potential drugs in hepatocellular carcinoma. PMID:34285143
Type 2 dendritic cells mediate control of cytotoxic T cell resistant tumors. PMID:34283809
Single Cell Genetic Profiling of Tumors of Breast Cancer Patients Aged 50 Years and Older Reveals Enormous Intratumor Heterogeneity Independent of Individual Prognosis. PMID:34282768
Pursuit of Gene Fusions in Daily Practice: Evidence from Real-World Data in Wild-Type and Microsatellite Instable Patients. PMID:34282766
Development of a Novel Immune Infiltration-Related ceRNA Network and Prognostic Model for Sarcoma. PMID:34277600
Comprehensive Transcriptomic Analysis Reveals the Role of the Immune Checkpoint HLA-G Molecule in Cancers. PMID:34276642
Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort. PMID:34276383
The Progenetix oncogenomic resource in 2021. PMID:34272855
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. PMID:34270926
A Robust Prognostic Gene Signature Based on eRNAs-Driven Genes in Prostate Cancer. PMID:34267780
KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype. PMID:34263179
A Platform for Validating Colorectal Cancer Driver Genes Using Mouse Organoids. PMID:34262603
Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortia. PMID:34262154
The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling. PMID:34262028
Epithelial Splicing Regulatory Protein 1 Is Overexpressed in Breast Cancer and Predicts Poor Prognosis for Breast Cancer Patients. PMID:34262011
Integrated digital pathology at scale: A solution for clinical diagnostics and cancer research at a large academic medical center. PMID:34260720
Accelerating precision medicine in metastatic prostate cancer. PMID:34258585
Notch1 Deficiency Induces Tumor Cell Accumulation Inside the Bronchiolar Lumen and Increases TAZ Expression in an Autochthonous Kras LSL-G12V Driven Lung Cancer Mouse Model. PMID:34257546
Expression, Prognosis and Gene Regulation Network of NFAT Transcription Factors in Non-Small Cell Lung Cancer. PMID:34257525
A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases. PMID:34253785
PathCNN: interpretable convolutional neural networks for survival prediction and pathway analysis applied to glioblastoma. PMID:34252964
OncoThreads: visualization of large-scale longitudinal cancer molecular data. PMID:34252935
Methylation silencing CDH23 is a poor prognostic marker in diffuse large B-cell lymphoma. PMID:34252883
Data mining-based study of collagen type III alpha 1 (COL3A1) prognostic value and immune exploration in pan-cancer. PMID:34252356
Exceptional Response to Trastuzumab in a Heavily Pretreated Patient With ERBB3-Mutated Metastatic Breast Cancer. PMID:34250408
Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer. PMID:34250404
Identification of Targetable Gene Fusions and Structural Rearrangements to Foster Precision Medicine in KRAS Wild-Type Pancreatic Cancer. PMID:34250383
Novel Markers in Pediatric Acute Lymphoid Leukemia: The Role of ADAM6 in B Cell Leukemia. PMID:34249950
Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer. PMID:34249755
TFPI2 Promotes Perivascular Migration in an Angiotropism Model of Melanoma. PMID:34249699
Association of CLDN6 and CLDN10 With Immune Microenvironment in Ovarian Cancer: A Study of the Claudin Family. PMID:34249076
Pan-Cancer Analysis Identifies Liver Metastases as Negative Predictive Factor for Immune Checkpoint Inhibitors Treatment Outcome. PMID:34248939
Bioinformatics analysis of the role of CXC ligands in the microenvironment of head and neck tumor. PMID:34247149
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine. PMID:34244484
Role of chromosome 1q copy number variation in hepatocellular carcinoma. PMID:34239701
Neuropilin-1: A feasible link between liver pathologies and COVID-19. PMID:34239266
Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells. PMID:34239121
Thioredoxin reductase is a major regulator of metabolism in leukemia cells. PMID:34239044
Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression. PMID:34237057
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis. PMID:34237033
Molecular Associations and Clinical Significance of RAPs in Hepatocellular Carcinoma. PMID:34235179
A miR-212-3p/SLC6A1 Regulatory Sub-Network for the Prognosis of Hepatocellular Carcinoma. PMID:34234551
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma. PMID:34231338
Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication. PMID:34228709
Prognostic and immunological value of ATP6AP1 in breast cancer: implications for SARS-CoV-2. PMID:34228637
Abnormal expression and methylation of PRR34-AS1 are associated with adverse outcomes in acute myeloid leukemia. PMID:34227248
Molecular basis for RASSF10/NPM/RNF2 feedback cascade-mediated regulation of gastric cancer cell proliferation. PMID:34224728
Bioinformatics Analysis of GFAP as a Potential Key Regulator in Different Immune Phenotypes of Prostate Cancer. PMID:34222466
CBX4 Provides an Alternate Mode of Colon Cancer Development via Potential Influences on Circadian Rhythm and Immune Infiltration. PMID:34222240
De Novo Mutation in Non-Tyrosine Kinase Domain of ROS1 as a Potential Predictor of Immune Checkpoint Inhibitors in Melanoma. PMID:34221982
A Novel Immune-Related Prognostic Signature in Head and Neck Squamous Cell Carcinoma. PMID:34220923
On the Use of Topological Features of Metabolic Networks for the Classification of Cancer Samples. PMID:34220296
The pattern of gene copy number alteration (CNAs) in hepatocellular carcinoma: an in silico analysis. PMID:34215297
eVIP2: Expression-based variant impact phenotyping to predict the function of gene variants. PMID:34214079
A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated prostate cancer. PMID:34211036
CACNA1C is a prognostic predictor for patients with ovarian cancer. PMID:34210324
Abnormal Long Non-Coding RNAs Expression Patterns Have the Potential Ability for Predicting Survival and Treatment Response in Breast Cancer. PMID:34209776
Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer. PMID:34209750
Integrative cBioPortal Analysis Revealed Molecular Mechanisms That Regulate EGFR-PI3K-AKT-mTOR Pathway in Diffuse Gliomas of the Brain. PMID:34209611
Regulatory SNPs: Altered Transcription Factor Binding Sites Implicated in Complex Traits and Diseases. PMID:34208629
Upper Aerodigestive Tract Squamous Cell Carcinomas Show Distinct Overall DNA Methylation Profiles and Different Molecular Mechanisms behind WNT Signaling Disruption. PMID:34208581
Evaluation of Darolutamide (ODM201) Efficiency on Androgen Receptor Mutants Reported to Date in Prostate Cancer Patients. PMID:34208290
DNA Methylation Markers from Negative Surgical Margins Can Predict Recurrence of Oral Squamous Cell Carcinoma. PMID:34207933
Clinicopathological Significance of Syndecan-1 in Cholangiocarcinoma: A Study Based on Immunohistochemistry and Public Sequencing Data. PMID:34206469
Gene Expression Profiles Associated with Radio-Responsiveness in Locally Advanced Rectal Cancer. PMID:34205090
Evaluation of Somatic Mutations in Solid Metastatic Pan-Cancer Patients. PMID:34204917
Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types. PMID:34202528
Multiplex Patient-Based Drug Response Assay in Pancreatic Ductal Adenocarcinoma. PMID:34201419
Integrative Transcriptomic Analysis Reveals Distinctive Molecular Traits and Novel Subtypes of Collecting Duct Carcinoma. PMID:34200770
Molecular Characterization of Muellerian Tumors of the Urinary Tract. PMID:34200508
Biphasic α2β1 Integrin Expression in Breast Cancer Metastasis to Bone. PMID:34199096
miRNA Clusters with Up-Regulated Expression in Colorectal Cancer. PMID:34198662
WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-κB activation. PMID:34197030
Comprehensive analysis of cytoskeleton regulatory genes identifies ezrin as a prognostic marker and molecular target in acute myeloid leukemia. PMID:34196912
Analyzing the influence of IL18 in regulation of YAP1 in breast oncogenesis using cBioportal. PMID:34196131
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. PMID:34192534
SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling. PMID:34187905
Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo. PMID:34187574
Functions and clinical significance of KLRG1 in the development of lung adenocarcinoma and immunotherapy. PMID:34187403
Identification of Endogenous Kinase Substrates by Proximity Labeling Combined with Kinase Perturbation and Phosphorylation Motifs. PMID:34186244
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation. PMID:34186021
HAI-1 is an independent predictor of lung cancer mortality and is required for M1 macrophage polarization. PMID:34185790
CRY2 missense mutations suppress P53 and enhance cell growth. PMID:34183418
A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis. PMID:34180355
Quantum processor-inspired machine learning in the biomedical sciences. PMID:34179840
ADHFE1 is a correlative factor of patient survival in cancer. PMID:34179501
MCM4 Is a Novel Biomarker Associated With Genomic Instability, BRCAness Phenotype, and Therapeutic Potentials in Soft-Tissue Sarcoma. PMID:34178990
Prevalence and Spectrum of Germline BRCA1 and BRCA2 Variants of Uncertain Significance in Breast/Ovarian Cancer: Mysterious Signals From the Genome. PMID:34178674
Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value. PMID:34178669
LpCat1 Promotes Malignant Transformation of Hepatocellular Carcinoma Cells by Directly Suppressing STAT1. PMID:34178664
The Gain-of-Function p53 R248W Mutant Promotes Migration by STAT3 Deregulation in Human Pancreatic Cancer Cells. PMID:34178628
p38β - MAPK11 and its role in female cancers. PMID:34174910
SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma. PMID:34173014
A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma. PMID:34172930
MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancer. PMID:34172788
The clinical and molecular significance associated with STING signaling in breast cancer. PMID:34172750
COVID-19 and Malignancy: Exploration of the possible genetic and epigenetic interlinks and overview of the vaccination scenario. PMID:34171559
Regulation of CD47 expression by interferon-gamma in cancer cells. PMID:34171557
Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity. PMID:34171264
SLC15A4 Serves as a Novel Prognostic Biomarker and Target for Lung Adenocarcinoma. PMID:34168674
Molecular alterations in basal cell carcinoma subtypes. PMID:34168209
RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer. PMID:34168046
HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML. PMID:34167558
A comprehensive database for integrated analysis of omics data in autoimmune diseases. PMID:34167460
SLC7A5 serves as a prognostic factor of breast cancer and promotes cell proliferation through activating AKT/mTORC1 signaling pathway. PMID:34164526
Earlier extracranial progression and shorter survival in ALK-rearranged lung cancer with positive liquid rebiopsies. PMID:34164264
Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors. PMID:34163353
Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia. PMID:34162911
CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents. PMID:34161330
Insights of fibroblast growth factor receptor 3 aberrations in pan-cancer and their roles in potential clinical treatment. PMID:34160364
Long-term disease control and survival observed after stereotactic ablative body radiotherapy for oligometastatic breast cancer. PMID:34159748
CALM supports clathrin-coated vesicle completion upon membrane tension increase. PMID:34155137
Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK-YAP Signaling. PMID:34151545
ALKBH1-8 and FTO: Potential Therapeutic Targets and Prognostic Biomarkers in Lung Adenocarcinoma Pathogenesis. PMID:34150745
Expression status and prognostic value of the perilipin family of genes in breast cancer. PMID:34150026
Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells. PMID:34149804
TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma. PMID:34148105
Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. PMID:34145784
Fatty Acid Synthesis in Prostate Cancer: Vulnerability or Epiphenomenon? PMID:34145040
E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer. PMID:34145034
Online database for brain cancer-implicated genes: exploring the subtype-specific mechanisms of brain cancer. PMID:34144671
p85β alters response to EGFR inhibitor in ovarian cancer through p38 MAPK-mediated regulation of DNA repair. PMID:34144267
E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer. PMID:34143182
Construction of a Myc-associated ceRNA network reveals a prognostic signature in hepatocellular carcinoma. PMID:34141458
DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma. PMID:34140574
Erlotinib and Onalespib Lactate Focused on EGFR Exon 20 Insertion Non-Small Cell Lung Cancer (NSCLC): A California Cancer Consortium Phase I/II Trial (NCI 9878). PMID:34140248
Whole-Exome Sequencing Analysis of Oral Squamous Cell Carcinoma Delineated by Tobacco Usage Habits. PMID:34136393
Making fundamental scientific discoveries by combining information from literature, databases, and computational tools - An example. PMID:34136100
Mutant p53s and chromosome 19 microRNA cluster overexpression regulate cancer testis antigen expression and cellular transformation in hepatocellular carcinoma. PMID:34135394
Immunotherapy in endometrial cancer: rationale, practice and perspectives. PMID:34134781
Telomere Attrition and p53 Response 1 (TAPR1): a new player in cancer biology? PMID:34133663
The role of RB1 alteration and 4q12 amplification in IDH-WT glioblastoma. PMID:34131647
Adipogenesis in triple-negative breast cancer is associated with unfavorable tumor immune microenvironment and with worse survival. PMID:34131208
Absent in melanoma 1-like (AIM1L) serves as a novel candidate for overall survival in hepatocellular carcinoma. PMID:34130591
Copy number alterations identify a smoking-associated expression signature predictive of poor outcome in head and neck squamous cell carcinoma. PMID:34130230
Molecular classification and diagnostics of upper urinary tract urothelial carcinoma. PMID:34129823
Immune infiltration phenotypes of prostate adenocarcinoma and their clinical implications. PMID:34128342
Immu-Mela: An open resource for exploring immunotherapy-related multidimensional genomic profiles in melanoma. PMID:34127402
In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function. PMID:34125870
Establishment of Novel Prostate Cancer Risk Subtypes and A Twelve-Gene Prognostic Model. PMID:34124157
IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment. PMID:34123844
Highly connected, non-redundant microRNA functional control in breast cancer molecular subtypes. PMID:34123357
METTL14 Acts as a Potential Regulator of Tumor Immune and Progression in Clear Cell Renal Cell Carcinoma. PMID:34122497
PSMA radioligand therapy for solid tumors other than prostate cancer: background, opportunities, challenges, and first clinical reports. PMID:34120192
The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer. PMID:34118960
Oncogene-regulated release of extracellular vesicles. PMID:34118203
Identification of a Novel Inflamed Tumor Microenvironment Signature as a Predictive Biomarker of Bacillus Calmette-Guérin Immunotherapy in Non-Muscle-Invasive Bladder Cancer. PMID:34117034
Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation. PMID:34116687
Identification of potential diagnostic biomarkers in MMPs for pancreatic carcinoma. PMID:34114996
A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma. PMID:34114970
Human Gastric Cancer Stem Cell (GCSC) Markers Are Prognostic Factors Correlated With Immune Infiltration of Gastric Cancer. PMID:34113647
A Bioinformatics Analysis of the Potential Roles of Aquaporin 4 in Human Brain Tumors: An Immune-Related Process. PMID:34113257
Hyaluronan-mediated motility receptor expression functions as a prognostic biomarker in uterine carcinosarcoma based on bioinformatics analysis. PMID:34111996
Expression pattern and prognostic impact of glycoprotein non-metastatic B (GPNMB) in triple-negative breast cancer. PMID:34108545
Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer. PMID:34108519
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer. PMID:34108441
Heterogeneity in NECTIN4 Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin. PMID:34108177
STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR/MAPK signaling pathway. PMID:34102455
FOXA1 overexpression suppresses interferon signaling and immune response in cancer. PMID:34101624
Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer. PMID:34100918
Alterations in the RTK/Ras/PI3K/AKT pathway serve as potential biomarkers for immunotherapy outcome of diffuse gliomas. PMID:34100771
Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer. PMID:34099734
Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma. PMID:34097975
Integrating Somatic and Germline Next-Generation Sequencing Into Routine Clinical Oncology Practice. PMID:34095711
ITGA3 Is Associated With Immune Cell Infiltration and Serves as a Favorable Prognostic Biomarker for Breast Cancer. PMID:34094951
High Expression of RhoBTB3 Predicts Favorable Chemothrapy Outcomes in non-M3 Acute Myeloid Leukemia. PMID:34093823
Glyoxalase 1 and protein kinase Cλ as potential therapeutic targets for late-stage breast cancer. PMID:34093768
Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM). PMID:34088988
CXCL2/10/12/14 are prognostic biomarkers and correlated with immune infiltration in hepatocellular carcinoma. PMID:34085699
A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance. PMID:34085047
Mice with dysfunctional TGF-β signaling develop altered intestinal microbiome and colorectal cancer resistant to 5FU. PMID:34082069
MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF. PMID:34079078
The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51. PMID:34077419
ENTPD5: identification of splicing variants and their impact on cancer survival. PMID:34075526
A mosaic PIK3CA variant in a young adult with diffuse gastric cancer: case report. PMID:34075207
Pan-cancer analysis of the prognostic value of C12orf75 based on data mining. PMID:34074799
Epithelial-Mesenchymal Transition Gene Signature Related to Prognostic in Colon Adenocarcinoma. PMID:34073426
In-Silico Evaluation of Genetic Alterations in Ovarian Carcinoma and Therapeutic Efficacy of NSC777201, as a Novel Multi-Target Agent for TTK, NEK2, and CDK1. PMID:34072728
PERK/ATF4-Dependent ZFAS1 Upregulation Is Associated with Sorafenib Resistance in Hepatocellular Carcinoma Cells. PMID:34072570
LncRNA PART1 Promotes Proliferation and Migration, Is Associated with Cancer Stem Cells, and Alters the miRNA Landscape in Triple-Negative Breast Cancer. PMID:34072264
Multi-Omics Model Applied to Cancer Genetics. PMID:34072237
Targeting Natural Killer T Cells in Solid Malignancies. PMID:34072042
Enhanced Thermogenesis in Triple-Negative Breast Cancer Is Associated with Pro-Tumor Immune Microenvironment. PMID:34071012
Survival-Critical Genes Associated with Copy Number Alterations in Lung Adenocarcinoma. PMID:34070461
A Keratin 7 and E-Cadherin Signature Is Highly Predictive of Tubo-Ovarian High-Grade Serous Carcinoma Prognosis. PMID:34070214
Prognostic Role of Immune Checkpoint Regulators in Cholangiocarcinoma: A Pilot Study. PMID:34069452
Regulation of the Phosphoinositide Code by Phosphorylation of Membrane Readers. PMID:34069055
Sequence Neighborhoods Enable Reliable Prediction of Pathogenic Mutations in Cancer Genomes. PMID:34068918
ELTD1-An Emerging Silent Actor in Cancer Drama Play. PMID:34068040
Molecular Mechanisms of PD-1 and PD-L1 Activity on a Pan-Cancer Basis: A Bioinformatic Exploratory Study. PMID:34067485
LIMK2-NKX3.1 Engagement Promotes Castration-Resistant Prostate Cancer. PMID:34066036
Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics. PMID:34065652
A Novel Three-Gene Score as a Predictive Biomarker for Pathologically Complete Response after Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer. PMID:34065619
Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells-Relevance for Understanding (Germ Cell) Tumorigenesis. PMID:34065345
RLIP76: A Structural and Functional Triumvirate. PMID:34064388
High glucose induced c-Met activation promotes aggressive phenotype and regulates expression of glucose metabolism genes in HCC cells. PMID:34059694
SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA-deficient cells. PMID:34058059
Utilizing Publicly Available Cancer Clinicogenomic Data on CBioPortal to Compare Epidermal Growth Factor Receptor Mutant and Wildtype Non-Small Cell Lung Cancer. PMID:34055528
A case series of extraneural metastatic glioblastoma at Memorial Sloan Kettering Cancer Center. PMID:34055380
Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis. PMID:34052835
OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis. PMID:34050636
Amplification of RAD54B promotes progression of hepatocellular carcinoma via activating the Wnt/β-catenin signaling. PMID:34049150
Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer. PMID:34047812
Recurrent Somatic MAP2K1 Mutations in Papillary Thyroid Cancer and Colorectal Cancer. PMID:34046359
Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma. PMID:34045512
MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer. PMID:34045467
The effects of ARID1A mutations on colorectal cancer and associations with PD-L1 expression by stromal cells. PMID:34042312
Identification of prognostic and bone metastasis-related alternative splicing signatures in mesothelioma. PMID:34041868
Somatic PIK3R1 variation as a cause of vascular malformations and overgrowth. PMID:34040190
High Response Rate and Durability Driven by HLA Genetic Diversity in Patients with Kidney Cancer Treated with Lenvatinib and Pembrolizumab. PMID:34039647
TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models. PMID:34039392
Cancer cell metabolism connects epigenetic modifications to transcriptional regulation. PMID:34036737
Increased expression of KPNA2 predicts unfavorable prognosis in ovarian cancer patients, possibly by targeting KIF4A signaling. PMID:34034774
Transcription Factor-Binding Site Identification and Enrichment Analysis. PMID:34033108
Mammary epithelial cells have lineage-rooted metabolic identities. PMID:34031589
Improved methods for RNAseq-based alternative splicing analysis. PMID:34031440
In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy. PMID:34031411
driveR: a novel method for prioritizing cancer driver genes using somatic genomics data. PMID:34030627
Identification of combinations of somatic mutations that predict cancer survival and immunotherapy benefit. PMID:34027407
MLH1 Deficiency Down-Regulates TLR4 Expression in Sporadic Colorectal Cancer. PMID:34026821
CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway. PMID:34026424
Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma. PMID:34025662
Role of the ABL tyrosine kinases in the epithelial-mesenchymal transition and the metastatic cascade. PMID:34022881
Upregulated functional gene expression programmes in tumour pericytes mark progression in patients with low-grade glioma. PMID:34018679
Hub biomarkers for the diagnosis and treatment of glioblastoma based on microarray technology. PMID:34018447
Mutation and Copy Number Alterations Analysis of KIF23 in Glioma. PMID:34017355
Mutational signatures impact the evolution of anti-EGFR antibody resistance in colorectal cancer. PMID:34017094
Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer. PMID:34016083
Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma. PMID:34015961
Obscurin: A multitasking giant in the fight against cancer. PMID:34015411
Role of ZBTB7A zinc finger in tumorigenesis and metastasis. PMID:34014468
The Role of Neurodevelopmental Pathways in Brain Tumors. PMID:34012965
Genomic evolutionary trajectory of metastatic squamous cell carcinoma of the lung. PMID:34012793
The roles of the cell division cycle-associated gene family in hepatocellular carcinoma. PMID:34012666
Comprehensive analysis of the prognostic value of the chemokine-like factor-like MARVEL transmembrane domain-containing family in gastric cancer. PMID:34012634
Expression and prognostic significance of thrombospondin gene family in gastric cancer. PMID:34012631
Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer. PMID:34011995
β-arrestin 2 stimulates degradation of HIF-1α and modulates tumor progression of glioblastoma. PMID:34007068
Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure. PMID:34003820
Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1. PMID:34003553
Downregulation of USP18 reduces tumor-infiltrating activated dendritic cells in extranodal diffuse large B cell lymphoma patients. PMID:34001679
The Role of Fibroblast Growth Factor 19 in Hepatocellular Carcinoma. PMID:34000282
Diagnostic, Therapeutic, and Prognostic Value of the Thrombospondin Family in Gastric Cancer. PMID:33996903
Chaperonin-Containing TCP1 Complex (CCT) Promotes Breast Cancer Growth Through Correlations With Key Cell Cycle Regulators. PMID:33996588
MTFR2, A Potential Biomarker for Prognosis and Immune Infiltrates, Promotes Progression of Gastric Cancer Based on Bioinformatics Analysis and Experiments. PMID:33995638
Extracellular Vesicles: A Novel Tool Facilitating Personalized Medicine and Pharmacogenomics in Oncology. PMID:33995103
Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer. PMID:33993095
Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response. PMID:33992077
Enabling Precision Medicine in Cancer Care Through a Molecular Data Warehouse: The Moffitt Experience. PMID:33989014
The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription-replication conflicts. PMID:33986538
FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036. PMID:33980863
Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion. PMID:33980181
BRAFnon-V600E more frequently co-occurs with IDH1/2 mutations in adult patients with gliomas than in patients harboring BRAFV600E but without a survival advantage. PMID:33980169
Expression Pattern and Prognostic Value of EPHA/EFNA in Breast Cancer by Bioinformatics Analysis: Revealing Its Importance in Chemotherapy. PMID:33977106
Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy. PMID:33976322
Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly. PMID:33976187
EGR1/2 Inhibits Papillary Thyroid Carcinoma Cell Growth by Suppressing the Expression of PTEN and BAX. PMID:33973090
Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence. PMID:33972599
Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes. PMID:33972523
Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas. PMID:33972520
AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer. PMID:33972443
Discovery of Candidate DNA Methylation Cancer Driver Genes. PMID:33972312
Knowledge bases and software support for variant interpretation in precision oncology. PMID:33971666
Validation of the functions and prognostic values of synapse-associated proteins in lower-grade glioma. PMID:33969375
Expression pattern of histone lysine-specific demethylase 6B in gastric cancer. PMID:33968207
Neutrophil Elastase Defects in Congenital Neutropenia. PMID:33968054
HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers. PMID:33966634
RFX1: a promising therapeutic arsenal against cancer. PMID:33964962
Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461. PMID:33963218
Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period. PMID:33963205
Intrahepatic Cholangiocarcinoma with Lymph Node Metastasis: Treatment-Related Outcomes and the Role of Tumor Genomics in Patient Selection. PMID:33963001
EARN: an ensemble machine learning algorithm to predict driver genes in metastatic breast cancer. PMID:33962648
A prognostic model based on seven immune-related genes predicts the overall survival of patients with hepatocellular carcinoma. PMID:33962640
Prognostic value of members of NFAT family for pan-cancer and a prediction model based on NFAT2 in bladder cancer. PMID:33962392
Evaluation of BRCA1 and BRCA2 as Indicators of Response to Immune Checkpoint Inhibitors. PMID:33961040
Analysis of the EGFR Amplification and CDKN2A Deletion Regulated Transcriptomic Signatures Reveals the Prognostic Significance of SPATS2L in Patients With Glioma. PMID:33959491
Developing Precision Medicine for Bladder Cancer. PMID:33958155
Systematic interrogation of mutation groupings reveals divergent downstream expression programs within key cancer genes. PMID:33957863
Smoothened loss is a characteristic of neuroendocrine prostate cancer. PMID:33955576
Predictive Value of KDM5C Alterations for Immune Checkpoint Inhibitors Treatment Outcomes in Patients With Cancer. PMID:33953726
SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site. PMID:33953332
Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes. PMID:33947695
S100A4 Is Involved in Stimulatory Effects Elicited by the FGF2/FGFR1 Signaling Pathway in Triple-Negative Breast Cancer (TNBC) Cells. PMID:33946884
Genomic Characterization of Concurrent Alterations in Non-Small Cell Lung Cancer (NSCLC) Harboring Actionable Mutations. PMID:33946519
Targeting epigenetic mechanisms to overcome venetoclax resistance. PMID:33945824
CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer. PMID:33945523
The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling. PMID:33941855
Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy. PMID:33941852
Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer. PMID:33937026
Advances of Fibroblast Growth Factor/Receptor Signaling Pathway in Hepatocellular Carcinoma and its Pharmacotherapeutic Targets. PMID:33935756
SMYD2 promotes tumorigenesis and metastasis of lung adenocarcinoma through RPS7. PMID:33935284
Comprehensive analysis of prognostic value and immune infiltration of kindlin family members in non-small cell lung cancer. PMID:33934696
MRPL15 is a novel prognostic biomarker and therapeutic target for epithelial ovarian cancer. PMID:33934540
Prostate cancer patient-derived organoids: detailed outcome from a prospective cohort of 81 clinical specimens. PMID:33934365
Targeting the PI3K and MAPK pathways to improve response to HER2-targeted therapies in HER2-positive gastric cancer. PMID:33933113
Identification of inhibitory immune checkpoints and relevant regulatory pathways in breast cancer stem cells. PMID:33932112
Mutant KRAS Downregulates the Receptor for Leukemia Inhibitory Factor (LIF) to Enhance a Signature of Glycolysis in Pancreatic Cancer and Lung Cancer. PMID:33931487
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer. PMID:33931024
Control of Breast Cancer Pathogenesis by Histone Methylation and the Hairless Histone Demethylase. PMID:33928351
Four Novel Prognostic Genes Related to Prostate Cancer Identified Using Co-expression Structure Network Analysis. PMID:33927744
MGA Mutation as a Novel Biomarker for Immune Checkpoint Therapies in Non-Squamous Non-Small Cell Lung Cancer. PMID:33927616
Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort. PMID:33927264
Ten-eleven translocation protein 1 modulates medulloblastoma progression. PMID:33926529
Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex. PMID:33925740
Genomic Correlates of DNA Damage in Breast Cancer Subtypes. PMID:33925616
LAG-3 Blockade with Relatlimab (BMS-986016) Restores Anti-Leukemic Responses in Chronic Lymphocytic Leukemia. PMID:33925565
ING Proteins: Tumour Suppressors or Oncoproteins. PMID:33925563
The Role of Wild-Type RAS in Oncogenic RAS Transformation. PMID:33924994
The ECM Modulator ITIH5 Affects Cell Adhesion, Motility and Chemotherapeutic Response of Basal/Squamous-Like (BASQ) Bladder Cancer Cells. PMID:33924987
The Role of p53 Signaling in Colorectal Cancer. PMID:33924934
KLF5 Is Activated by Gene Amplification in Gastric Cancer and Is Essential for Gastric Cell Proliferation. PMID:33923166
PRKCA Overexpression Is Frequent in Young Oral Tongue Squamous Cell Carcinoma Patients and Is Associated with Poor Prognosis. PMID:33923093
Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. PMID:33922599
The Emerging Clinical Role of Spermine in Prostate Cancer. PMID:33922247
A Bioinformatics Analysis Identifies the Telomerase Inhibitor MST-312 for Treating High-STMN1-Expressing Hepatocellular Carcinoma. PMID:33922244
MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model. PMID:33921698
The Expression Regulation and Biological Function of Autotaxin. PMID:33921676
Melanoma Associated Chitinase 3-Like 1 Promoted Endothelial Cell Activation and Immune Cell Recruitment. PMID:33920100
RNA Expression of DNA Damage Response Genes in Muscle-Invasive Bladder Cancer: Influence on Outcome and Response to Adjuvant Cisplatin-Based Chemotherapy. PMID:33919527
Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses. PMID:33918976
Neuropilin-2 and Its Transcript Variants Correlate with Clinical Outcome in Bladder Cancer. PMID:33918816
Loss of the Metastasis Suppressor NME1, But Not of Its Highly Related Isoform NME2, Induces a Hybrid Epithelial-Mesenchymal State in Cancer Cells. PMID:33918324
CK2 Activity Mediates the Aggressive Molecular Signature of Glioblastoma Multiforme by Inducing Nerve/Glial Antigen (NG)2 Expression. PMID:33918235
Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer. PMID:33918004
The rs599839 A>G Variant Disentangles Cardiovascular Risk and Hepatocellular Carcinoma in NAFLD Patients. PMID:33917919
Tumor Signature Analysis Implicates Hereditary Cancer Genes in Endometrial Cancer Development. PMID:33917078
Neurological Disorders Associated with WWOX Germline Mutations-A Comprehensive Overview. PMID:33916893
Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation. PMID:33916378
Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors. PMID:33914855
Identification of Expression Patterns and Potential Prognostic Significance of m5C-Related Regulators in Head and Neck Squamous Cell Carcinoma. PMID:33912441
A New Insight for the Identification of Oncogenic Variants in Breast and Prostate Cancers in Diverse Human Populations, With a Focus on Latinos. PMID:33912047
Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities. PMID:33910596
Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action. PMID:33909629
Diffuse midline glioma with H3 K27M-mutation in an 83-year-old woman. PMID:33908265
ARHGAP20 Expression Inhibited HCC Progression by Regulating the PI3K-AKT Signaling Pathway. PMID:33907697
The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells. PMID:33907253
Prostate epithelial genes define therapy-relevant prostate cancer molecular subtype. PMID:33903734
The lncRNA GATA3-AS1/miR-495-3p/CENPU axis predicts poor prognosis of breast cancer via the PLK1 signaling pathway. PMID:33902008
Identification of Epithelial-Mesenchymal Transition-Related lncRNAs that Associated With the Prognosis and Immune Microenvironment in Colorectal Cancer. PMID:33898515
Study on the Prognostic Values of Dynactin Genes in Low-Grade Glioma. PMID:33896271
Update on genomic and molecular landscapes of well-differentiated liposarcoma and dedifferentiated liposarcoma. PMID:33893924
Prognostic biomarkers and therapeutic targets in oral squamous cell carcinoma: a study based on cross-database analysis. PMID:33892811
The converging roles of Batten disease proteins in neurodegeneration and cancer. PMID:33889828
HER2 transmembrane domain mutation: comprehensive characteristics and real-world evidence of treatment response in Chinese lung adenocarcinoma. PMID:33889517
Predicting clinical outcomes using cancer progression associated signatures. PMID:33889305
Up to your NEK2 in CIN. PMID:33889296
Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens. PMID:33888849
Surface Expression of Kynurenine 3-Monooxygenase Promotes Proliferation and Metastasis in Triple-Negative Breast Cancers. PMID:33887987
Epidermal growth factor receptor regulates fibrinolytic pathway elements in cervical cancer: functional and prognostic implications. PMID:33886813
Impact of splicing mutations in acute myeloid leukemia treated with hypomethylating agents combined with venetoclax. PMID:33885753
Gene Expression and Data Analysis Pipeline Using Cancer BioPortal in the Classroom. PMID:33884053
Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer. PMID:33883167
CDC20 and PTTG1 are Important Biomarkers and Potential Therapeutic Targets for Metastatic Prostate Cancer. PMID:33881746
PTEN mutations predict benefit from tumor treating fields (TTFields) therapy in patients with recurrent glioblastoma. PMID:33881725
Bioinformatics and In Vitro Studies Reveal the Importance of p53, PPARG and Notch Signaling Pathway in Inhibition of Breast Cancer Stem Cells by Hesperetin. PMID:33880358
MicroRNA-302s Might Regulate ARL4C-Mediated Gastric Cancer Progression via p53 Signaling: Bioinformatics Analysis and Experiments Validation. PMID:33880033
Identification of prognostic biomarkers associated with the occurrence of portal vein tumor thrombus in hepatocellular carcinoma. PMID:33878734
14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia. PMID:33876209
High estrogen receptor alpha activation confers resistance to estrogen deprivation and is required for therapeutic response to estrogen in breast cancer. PMID:33875787
SPRED proteins and their roles in signal transduction, development, and malignancy. PMID:33872193
The Metabolic Landscape of RAS-Driven Cancers from biology to therapy. PMID:33870211
A Non-canonical Wnt Signature Correlates With Lower Survival in Gastric Cancer. PMID:33869179
LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton. PMID:33869174
Mutated DNA Damage Repair Pathways Are Prognostic and Chemosensitivity Markers for Resected Colorectal Cancer Liver Metastases. PMID:33869034
Algorithm-Based Meta-Analysis Reveals the Mechanistic Interaction of the Tumor Suppressor LIMD1 With Non-Small-Cell Lung Carcinoma. PMID:33869018
CD80 expression is upregulated by TP53 activation in human cancer epithelial cells. PMID:33868791
DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression. PMID:33868478
Cytotoxic T-lymphocyte infiltration and chemokine predict long-term patient survival independently of tumor mutational burden in triple-negative breast cancer. PMID:33868461
RRM2B Is Frequently Amplified Across Multiple Tumor Types: Implications for DNA Repair, Cellular Survival, and Cancer Therapy. PMID:33868369
IκBα targeting promotes oxidative stress-dependent cell death. PMID:33863364
A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial. PMID:33862582
CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells. PMID:33861751
Comparison of metastatic castration-resistant prostate cancer in bone with other sites: clinical characteristics, molecular features and immune status. PMID:33859877
FCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress. PMID:33859174
Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis. PMID:33859162
The dystonia gene THAP1 controls DNA double-strand break repair choice. PMID:33857404
CRL4AMBRA1 is a master regulator of D-type cyclins. PMID:33854235
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. PMID:33854232
Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer. PMID:33853832
Metformin impairs cisplatin resistance effects in A549 lung cancer cells through mTOR signaling and other metabolic pathways. PMID:33846781
MAP3K7 Loss Drives Enhanced Androgen Signaling and Independently Confers Risk of Recurrence in Prostate Cancer with Joint Loss of CHD1. PMID:33846123
A cell-to-patient machine learning transfer approach uncovers novel basal-like breast cancer prognostic markers amongst alternative splice variants. PMID:33845831
Relationship of HER2 Alteration and Microsatellite Instability Status in Colorectal Adenocarcinoma. PMID:33844372
Epigenetic and metabolic interplay in cutaneous squamous cell carcinoma. PMID:33844325
Upregulation of GNPNAT1 Predicts Poor Prognosis and Correlates With Immune Infiltration in Lung Adenocarcinoma. PMID:33842535
mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 Are Druggable Candidates for N-(2,4-Difluorophenyl)-2',4'-Difluoro-4-Hydroxybiphenyl-3-Carboxamide (NSC765598), With Consequent Anticancer Implications. PMID:33842373
Colony Stimulating Factor 1 Receptor in Acute Myeloid Leukemia. PMID:33842370
CDKN2A Deletion in Melanoma Excludes T Cell Infiltration by Repressing Chemokine Expression in a Cell Cycle-Dependent Manner. PMID:33842347
Potential targets identified in adenoid cystic carcinoma point out new directions for further research. PMID:33841642
Nuclear factor IB is downregulated in vulvar squamous cell carcinoma (VSCC): Unravelling differentially expressed genes in VSCC through gene expression dataset analysis. PMID:33841565
Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma. PMID:33840169
Beyond Programmed Death-Ligand 1: B7-H6 Emerges as a Potential Immunotherapy Target in SCLC. PMID:33839362
BMP9-ID1 signaling promotes EpCAM-positive cancer stem cell properties in hepatocellular carcinoma. PMID:33834612
Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy. PMID:33834176
Whole-exome sequencing reveals the etiology of the rare primary hepatic mucoepidermoid carcinoma. PMID:33832503
Pan-genomic characterization of high-risk pediatric papillary thyroid carcinoma. PMID:33827048
Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors. PMID:33826903
Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapy. PMID:33822841
Vitamin D receptor upregulates lncRNA TOPORS-AS1 which inhibits the Wnt/β-catenin pathway and associates with favorable prognosis of ovarian cancer. PMID:33820921
A bioinformatic analysis of the inhibin-betaglycan-endoglin/CD105 network reveals prognostic value in multiple solid tumors. PMID:33819300
ORN: Inferring patient-specific dysregulation status of pathway modules in cancer with OR-gate Network. PMID:33819263
Growth Hormone/Insulin Growth Factor Axis in Sex Steroid Associated Disorders and Related Cancers. PMID:33816477
Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first-line platinum chemotherapy in high grade serous ovarian cancer. PMID:33811746
Constitutional 2p16.3 deletion including MSH6 and FBXO11 in a boy with developmental delay and diffuse large B-cell lymphoma. PMID:33811277
The Association between TIF1 Family Members and Cancer Stemness in Solid Tumors. PMID:33810347
Prognostic and Functional Significant of Heat Shock Proteins (HSPs) in Breast Cancer Unveiled by Multi-Omics Approaches. PMID:33810095
The Extracellular Small Leucine-Rich Proteoglycan Biglycan Is a Key Player in Gastric Cancer Aggressiveness. PMID:33809543
Aberrations of Chromosomes 1 and 16 in Breast Cancer: A Framework for Cooperation of Transcriptionally Dysregulated Genes. PMID:33808143
The CXCL2/IL8/CXCR2 Pathway Is Relevant for Brain Tumor Malignancy and Endothelial Cell Function. PMID:33807899
More Than Meets the Eye: Revisiting the Roles of Heat Shock Factor 4 in Health and Diseases. PMID:33807297
Gene Co-Expression Analysis of Human RNASEH2A Reveals Functional Networks Associated with DNA Replication, DNA Damage Response, and Cell Cycle Regulation. PMID:33805806
Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development-Review. PMID:33805800
Candidate Markers of Olaparib Response from Genomic Data Analyses of Human Cancer Cell Lines. PMID:33803939
The MEK1/2 Pathway as a Therapeutic Target in High-Grade Serous Ovarian Carcinoma. PMID:33803586
CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma. PMID:33803245
The Case for GNMT as a Biomarker and a Therapeutic Target in Pancreatic Cancer. PMID:33802396
A Detailed Catalogue of Multi-Omics Methodologies for Identification of Putative Biomarkers and Causal Molecular Networks in Translational Cancer Research. PMID:33802234
Linking Serine/Glycine Metabolism to Radiotherapy Resistance. PMID:33801846
Crk and CrkL as Therapeutic Targets for Cancer Treatment. PMID:33801580
Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis. PMID:33801331
Pathogenic Roles of S100A8 and S100A9 Proteins in Acute Myeloid and Lymphoid Leukemia: Clinical and Therapeutic Impacts. PMID:33801279
The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases. PMID:33800554
Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer. PMID:33799592
Androgen receptor signalling confers clonogenic and migratory advantages in urothelial cell carcinoma of the bladder. PMID:33797847
An In Silico Analysis Identified FZD9 as a Potential Prognostic Biomarker in Triple-Negative Breast Cancer Patients. PMID:33796830
Integrative Analysis of the Expression of SIGLEC Family Members in Lung Adenocarcinoma via Data Mining. PMID:33796453
Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer. PMID:33796412
Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways. PMID:33795256
The m6A Reader YTHDF1 Facilitates the Tumorigenesis and Metastasis of Gastric Cancer via USP14 Translation in an m6A-Dependent Manner. PMID:33791305
CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment. PMID:33791155
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. PMID:33789117
Viruses, cancer and non-self recognition. PMID:33784856
Expanding the genotypic and phenotypic spectrum in a diverse cohort of 104 individuals with Wiedemann-Steiner syndrome. PMID:33783954
Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis. PMID:33783919
Biochemical and structural characterization of analogs of MRE11 breast cancer-associated mutant F237C. PMID:33782469
PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion. PMID:33775697
Immune modulation underpins the anti-cancer activity of HDAC inhibitors. PMID:33773029
FUNGI: Fusion Gene Integration Toolset. PMID:33772596
Interferon regulatory factor 1 (IRF-1) downregulates Checkpoint kinase 1 (CHK1) through miR-195 to upregulate apoptosis and PD-L1 expression in Hepatocellular carcinoma (HCC) cells. PMID:33772151
CENP-A overexpression promotes distinct fates in human cells, depending on p53 status. PMID:33772115
The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer. PMID:33772001
Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity. PMID:33768207
Minerva: a light-weight, narrative image browser for multiplexed tissue images. PMID:33768192
Does Subtelomeric Position of COMMD5 Influence Cancer Progression? PMID:33768002
Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation. PMID:33767702
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway. PMID:33767426
A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells. PMID:33763657
Pan-cancer image-based detection of clinically actionable genetic alterations. PMID:33763651
High KIFC1 expression is associated with poor prognosis in prostate cancer. PMID:33760984
Single-cell analysis reveals metastatic cell heterogeneity in clear cell renal cell carcinoma. PMID:33759378
CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation. PMID:33758365
Overexpression of CCNE1 confers a poorer prognosis in triple-negative breast cancer identified by bioinformatic analysis. PMID:33757543
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. PMID:33756106
Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer. PMID:33756102
LIN28B induces a differentiation program through CDX2 in colon cancer. PMID:33755595
In search for biomarkers and potential drug targets for uterine serous endometrial cancer. PMID:33754208
The origins and genetic interactions of KRAS mutations are allele- and tissue-specific. PMID:33753749
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis. PMID:33753739
Integrated bioinformatic analysis of HNF1A in human cancers. PMID:33752475
The NFIB-ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells. PMID:33751828
NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer. PMID:33750924
A noncanonical AR addiction drives enzalutamide resistance in prostate cancer. PMID:33750801
Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer. PMID:33750350
Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function. PMID:33749663
Immune Modeling Analysis Reveals Immunologic Signatures Associated With Improved Outcomes in High Grade Serous Ovarian Cancer. PMID:33747935
Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma. PMID:33747576
miR-130a-3p promotes cell proliferation and invasion by targeting estrogen receptor α and androgen receptor in cervical cancer. PMID:33747155
Cutaneous Melanoma: Mutational Status and Potential Links to Tertiary Lymphoid Structure Formation. PMID:33746966
Aberrations in circulating ceramide levels are associated with poor clinical outcomes across localised and metastatic prostate cancer. PMID:33746214
Expression and molecular profiles of the AlkB family in ovarian serous carcinoma. PMID:33744868
Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis. PMID:33743547
Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis. PMID:33742106
Swiss-PO: a new tool to analyze the impact of mutations on protein three-dimensional structures for precision oncology. PMID:33737716
TFEB Promotes Prostate Cancer Progression via Regulating ABCA2-Dependent Lysosomal Biogenesis. PMID:33732651
A survey of cancer genome signatures identifies genes connected to distinct chromosomal instability phenotypes. PMID:33731882
Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer. PMID:33731859
Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress. PMID:33731803
Expression and prognosis analysis of GINS subunits in human breast cancer. PMID:33725952
Characterization of genetics in patients with mucosal melanoma treated with immune checkpoint blockade. PMID:33724703
Molecular features of untreated breast cancer and initial metastatic event inform clinical decision-making and predict outcome: long-term results of ESOPE, a single-arm prospective multicenter study. PMID:33722295
Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive (IDHwt) glioma is associated with H3K27me3 depletion and alternative promoter usage. PMID:33720519
G6PD-NF-κB-HGF Signal in Gastric Cancer-Associated Mesenchymal Stem Cells Promotes the Proliferation and Metastasis of Gastric Cancer Cells by Upregulating the Expression of HK2. PMID:33718248
Tumor Molecular Features Predict Endometrial Cancer Patients' Survival After Open or Minimally Invasive Surgeries. PMID:33718224
DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells. PMID:33718139
Identification of a novel immune-related microRNA prognostic model in clear cell renal cell carcinoma. PMID:33718090
Programmed death-ligand 1 expression level as a predictor of EGFR tyrosine kinase inhibitor efficacy in lung adenocarcinoma. PMID:33718015
Do Molecular Profiles of Primary Versus Metastatic Radioiodine Refractory Differentiated Thyroid Cancer Differ? PMID:33716974
SWI/SNF chromatin remodeling complex alterations in meningioma. PMID:33715086
Integrative analysis regarding the correlation between GAS2 family genes and human glioma prognosis. PMID:33713047
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. PMID:33712589
An epithelial-mesenchymal transition-related 5-gene signature predicting the prognosis of hepatocellular carcinoma patients. PMID:33712026
A comprehensive molecular characterization of the 8q22.2 region reveals the prognostic relevance of OSR2 mRNA in muscle invasive bladder cancer. PMID:33711044
Androgen receptor (AR) antagonism triggers acute succinate-mediated adaptive responses to reactivate AR signaling. PMID:33709547
Establishment of Novel DNA Methylation-Based Prostate Cancer Subtypes and a Risk-Predicting Eight-Gene Signature. PMID:33708770
High expression of aldolase A is associated with tumor progression and poor prognosis in hepatocellular carcinoma. PMID:33708434
Increased expression of MCM4 is associated with poor prognosis in patients with hepatocellular carcinoma. PMID:33708433
Identification of Core Genes Related to Progression and Prognosis of Hepatocellular Carcinoma and Small-Molecule Drug Predication. PMID:33708237
Identification of TRIM56 as a Potential Biomarker for Lung Adenocarcinoma. PMID:33707970
Differential alternative RNA splicing and transcription events between tumors from African American and White patients in The Cancer Genome Atlas. PMID:33705884
Significant non-existence of sequences in genomes and proteomes. PMID:33693858
NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer. PMID:33692855
Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response. PMID:33692370
GASC1 promotes hepatocellular carcinoma progression by inhibiting the degradation of ROCK2. PMID:33692332
Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair. PMID:33692124
In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer. PMID:33691672
Interferon regulatory factor 1(IRF-1) activates anti-tumor immunity via CXCL10/CXCR3 axis in hepatocellular carcinoma (HCC). PMID:33689775
FOXQ1 is Differentially Expressed Across Breast Cancer Subtypes with Low Expression Associated with Poor Overall Survival. PMID:33688250
Partial Response to Pyrotinib Plus Capecitabine in an Advanced Breast Cancer Patient with HER2 Amplification and R157W Mutation After Anti-HER2 Treatment: A Case Report and Literature Review. PMID:33688205
Expression and prognostic value of transcription-associated cyclin-dependent kinases in human breast cancer. PMID:33686962
Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors. PMID:33685991
Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with EGFR Exon 20 Insertions. PMID:33685865
Identification of tumor antigens and immune subtypes of cholangiocarcinoma for mRNA vaccine development. PMID:33685460
Deciphering the genetic alterations in matrix metallo-proteinase gene family and its putative association with head and neck squamous cell carcinoma. PMID:33681393
The Prognostic Value and Mechanisms of TMEM16A in Human Cancer. PMID:33681289
CD96 Correlates With Immune Infiltration and Impacts Patient Prognosis: A Pan-Cancer Analysis. PMID:33680972
KRAS mutation in pancreatic cancer. PMID:33676749
Molecular characterization of high-grade serous ovarian cancers occurring in younger and older women. PMID:33674143
Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer. PMID:33673346
Notch Signaling Pathway in Cancer-Review with Bioinformatic Analysis. PMID:33673145
Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer. PMID:33671201
Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics. PMID:33670680
Key Enzymes in Pyrimidine Synthesis, CAD and CPS1, Predict Prognosis in Hepatocellular Carcinoma. PMID:33670206
Downregulation of Cell Cycle and Checkpoint Genes by Class I HDAC Inhibitors Limits Synergism with G2/M Checkpoint Inhibitor MK-1775 in Bladder Cancer Cells. PMID:33670166
Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation. PMID:33669371
Multi-Omics Data Analysis of Gene Expressions and Alterations, Cancer-Associated Fibroblast and Immune Infiltrations, Reveals the Onco-Immune Prognostic Relevance of STAT3/CDK2/4/6 in Human Malignancies. PMID:33668805
Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer. PMID:33667385
Systemic Adaptive Immune Parameters Associated with Neuroblastoma Outcomes: the Significance of Gamma-Delta T Cells. PMID:33666857
E2F1: Cause and Consequence of DNA Replication Stress. PMID:33665206
Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients. PMID:33662628
MRPL13 Promotes Tumor Cell Proliferation, Migration and EMT Process in Breast Cancer Through the PI3K-AKT-mTOR Pathway. PMID:33658859
Integration of comprehensive genomic profiling, tumor mutational burden, and PD-L1 expression to identify novel biomarkers of immunotherapy in non-small cell lung cancer. PMID:33655698
MIG-6 is essential for promoting glucose metabolic reprogramming and tumor growth in triple-negative breast cancer. PMID:33655623
LRP1B mutations are associated with favorable outcomes to immune checkpoint inhibitors across multiple cancer types. PMID:33653800
Guanosine monophosphate synthase upregulation mediates cervical cancer progression by inhibiting the apoptosis of cervical cancer cells via the Stat3/P53 pathway. PMID:33649833
Identification of tumor antigens and immune subtypes of pancreatic adenocarcinoma for mRNA vaccine development. PMID:33648511
Protocol for proteogenomic dissection of intronic splicing enhancer interactome for prediction of individualized cancer prognosis. PMID:33644773
Enolase 1 Correlated With Cancer Progression and Immune-Infiltrating in Multiple Cancer Types: A Pan-Cancer Analysis. PMID:33643901
Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer. PMID:33643710
TMEM52B suppression promotes cancer cell survival and invasion through modulating E-cadherin stability and EGFR activity. PMID:33641663
Comprehensive Review of Molecular Mechanisms and Clinical Features of Invasive Lobular Cancer. PMID:33641217
Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas. PMID:33641091
Mutation-based clustering and classification analysis reveals distinctive age groups and age-related biomarkers for glioma. PMID:33639927
Transcriptional Biomarkers in Oral Cancer: An Integrative Analysis and the Cancer Genome Atlas Validation. PMID:33639650
Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors. PMID:33637626
Activated ALK Cooperates with N-Myc via Wnt/β-Catenin Signaling to Induce Neuroendocrine Prostate Cancer. PMID:33637566
Clinical benefit for clinical sequencing using cancer panel testing. PMID:33635883
Longitudinal CTCs gene expression analysis on metastatic castration-resistant prostate cancer patients treated with docetaxel reveals new potential prognosis markers. PMID:33635497
Low Expression of the Polycomb Protein RING1 Predicts Poor Prognosis in Human Breast Cancer. PMID:33634028
The Role of Interleukin-33 in Head and Neck Squamous Cell Carcinoma Is Determined by Its Cellular Sources in the Tumor Microenvironment. PMID:33634017
Identification and Validation of Efficacy of Immunological Therapy for Lung Cancer From Histopathological Images Based on Deep Learning. PMID:33633793
CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer. PMID:33633150
Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection. PMID:33632928
Susceptibility-Associated Genetic Variation in NEDD9 Contributes to Prostate Cancer Initiation and Progression. PMID:33632899
Comprehensive molecular profiling of Taiwanese breast cancers revealed potential therapeutic targets: prevalence of actionable mutations among 380 targeted sequencing analyses. PMID:33632156
Sparse data embedding and prediction by tropical matrix factorization. PMID:33632116
Potential Mechanism of Immune Evasion Associated with the Master Regulator ASCL2 in Microsatellite Stability in Colorectal Cancer. PMID:33628843
Reduced anoctamin 7 (ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer. PMID:33628598
How to Use Online Tools to Generate New Hypotheses for Mammary Gland Biology Research: A Case Study for Wnt7b. PMID:33625717
Exonuclease 1 (EXO1) is a Potential Prognostic Biomarker and Correlates with Immune Infiltrates in Lung Adenocarcinoma. PMID:33623391
Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes. PMID:33622998
High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability. PMID:33622270
Long non-coding RNA-based signature for predicting prognosis of hepatocellular carcinoma. PMID:33622186
Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A. PMID:33621062
YY1 regulated transcription-based stratification of gastric tumors and identification of potential therapeutic candidates. PMID:33620645
Immune classification of clear cell renal cell carcinoma. PMID:33619294
Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1. PMID:33619228
Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. PMID:33618763
Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Somatic Mutations in CDH1 and Other Clinically Actionable Mutations Imply Early Use of Targeted Agents. PMID:33617508
A Risk Prediction Model for Breast Cancer Based on Immune Genes Related to Early Growth Response Proteins Family. PMID:33614706
Down-Regulation of CIDEA Promoted Tumor Growth and Contributed to Cisplatin Resistance by Regulating the JNK-p21/Bad Signaling Pathways in Esophageal Squamous Cell Carcinoma. PMID:33614508
Autophagy Gene Panel-Based Prognostic Model in Myelodysplastic Syndrome. PMID:33614490
A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells. PMID:33613845
High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma. PMID:33613843
Transcription factor E2F4 is an indicator of poor prognosis and is related to immune infiltration in hepatocellular carcinoma. PMID:33613768
Stratification of Estrogen Receptor-Negative Breast Cancer Patients by Integrating the Somatic Mutations and Transcriptomic Data. PMID:33613637
ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition. PMID:33613118
Functional Prediction of Long Noncoding RNAs in Cutaneous Melanoma Using a Systems Biology Approach. PMID:33613027
Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data. PMID:33606788
Comprehensive Analysis of Prognostic and Immune Infiltrates for E2F Transcription Factors in Human Pancreatic Adenocarcinoma. PMID:33604289
Identification of potential therapeutic target of naringenin in breast cancer stem cells inhibition by bioinformatics and in vitro studies. PMID:33603536
Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression. PMID:33603163
Tumour gene expression signature in primary melanoma predicts long-term outcomes. PMID:33602918
Spatial Analysis and Clinical Significance of HLA Class-I and Class-II Subunit Expression in Non-Small Cell Lung Cancer. PMID:33602682
A distinct repertoire of cancer-associated fibroblasts is enriched in cribriform prostate cancer. PMID:33600062
Exploring the Differential Expression and Prognostic Significance of the COL11A1 Gene in Human Colorectal Carcinoma: An Integrated Bioinformatics Approach. PMID:33597969
Double inhibition and activation mechanisms of Ephexin family RhoGEFs. PMID:33597305
Identification of lipidomic profiles associated with drug-resistant prostate cancer cells. PMID:33596934
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity. PMID:33594203
Comprehensive analysis of macrophage-related multigene signature in the tumor microenvironment of head and neck squamous cancer. PMID:33592580
USP13 regulates the replication stress response by deubiquitinating TopBP1. PMID:33592542
Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. PMID:33591981
Clinical significance of STEAP1 extracellular vesicles in prostate cancer. PMID:33589770
Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. PMID:33588911
Evaluation of the susceptibility and fatality of lung cancer patients towards the COVID-19 infection: A systemic approach through analyzing the ACE2, CXCL10 and their co-expressed genes. PMID:33585826
Construction of Bone Metastasis-Specific Regulation Network Based on Prognostic Stemness-Related Signatures in Breast Invasive Carcinoma. PMID:33585235
Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer. PMID:33585209
The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype. PMID:33585078
Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions. PMID:33581682
Toll-Like Receptor 7 Mediates Inflammation Resolution and Inhibition of Angiogenesis in Non-Small Cell Lung Cancer. PMID:33578955
Differential Expression of a Panel of Ten CNTN1-Associated Genes during Prostate Cancer Progression and the Predictive Properties of the Panel Towards Prostate Cancer Relapse. PMID:33578925
Integrative Genomic Analyses of Patient-Matched Intracranial and Extracranial Metastases Reveal a Novel Brain-Specific Landscape of Genetic Variants in Driver Genes of Malignant Melanoma. PMID:33578810
Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma. PMID:33575479
CLIP4 Shows Putative Tumor Suppressor Characteristics in Breast Cancer: An Integrated Analysis. PMID:33575272
YEATS4 is associated with poor prognosis and promotes epithelial-to-mesenchymal transition and metastasis by regulating ZEB1 expression in breast cancer. PMID:33575079
Increased Expression of DNA2 Was Linked to Poor Prognosis in Breast Cancer. PMID:33574966
Targeted exome sequencing for the identification of common mutational signatures and potential driver mutations for brain metastases and prognosis. PMID:33574918
CC Chemokine Receptors in Lung Adenocarcinoma: The Inflammation-Related Prognostic Biomarkers and Immunotherapeutic Targets. PMID:33574689
Hematologic indices in individuals with pathogenic germline DICER1 variants. PMID:33570641
Solid tumours hijack the histone variant network. PMID:33568791
ZRSR2 overexpression is a frequent and early event in castration-resistant prostate cancer development. PMID:33568749
Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes. PMID:33568675
Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis. PMID:33568630
Integrated bioinformatic analysis identifies COL4A3, COL4A4, and KCNJ1 as key biomarkers in Wilms tumor. PMID:33564352
Inhibition of relaxin autocrine signaling confers therapeutic vulnerability in ovarian cancer. PMID:33561012
Identification of an immune-related risk signature and nomogram predicting the overall survival in patients with endometrial cancer. PMID:33559412
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide. PMID:33558541
Pan-Cancer Analysis Shows TP53 Mutations Modulate the Association of NOX4 with Genetic Programs of Cancer Progression and Clinical Outcome. PMID:33557266
Targeting the Hippo Pathway in Prostate Cancer: What's New? PMID:33557087
Personalized oncology and BRAFK601N melanoma: model development, drug discovery, and clinical correlation. PMID:33555379
Toll-like receptor 4 signaling activates ERG function in prostate cancer and provides a therapeutic target. PMID:33554122
Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer. PMID:33553736
Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer. PMID:33553693
Profiles of alternative splicing landscape in breast cancer and their clinical significance: an integrative analysis based on large-sequencing data. PMID:33553351
Genetic Architectures and Cell-of-Origin in Glioblastoma. PMID:33552990
Prognostic Implications of Pan-Cancer CMTM6 Expression and Its Relationship with the Immune Microenvironment. PMID:33552963
Suppression of p16 alleviates the senescence-associated secretory phenotype. PMID:33550279
Crystal structure of the human PRPK-TPRKB complex. PMID:33547416
NLRC5/CITA expression correlates with efficient response to checkpoint blockade immunotherapy. PMID:33547395
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma. PMID:33547292
Prostate cancer. PMID:33542230
High ROBO3 expression predicts poor survival in non-M3 acute myeloid leukemia. PMID:33541130
Evolutionary Conservation of Structural and Functional Coupling between the BRM AT-Hook and Bromodomain. PMID:33539881
Elevated NSD3 histone methylation activity drives squamous cell lung cancer. PMID:33536620
A short deletion in the DNA-binding domain of STAT3 suppresses growth and progression of colon cancer cells. PMID:33535185
Survival outcomes are associated with genomic instability in luminal breast cancers. PMID:33534788
Glycolytic expression in lower-grade glioma reveals an epigenetic association between IDH mutation status and PDL1/2 expression. PMID:33532725
Carbon ion triggered immunogenic necroptosis of nasopharyngeal carcinoma cells involving necroptotic inhibitor BCL-x. PMID:33531997
Construction of a Glycolysis-related long noncoding RNA signature for predicting survival in endometrial cancer. PMID:33531988
Identification of novel biomarkers and candidate small-molecule drugs in cutaneous melanoma by comprehensive gene microarrays analysis. PMID:33531976
Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling. PMID:33531625
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer. PMID:33531470
Preclinical Evaluation of B7-H3-specific Chimeric Antigen Receptor T Cells for the Treatment of Acute Myeloid Leukemia. PMID:33531429
Hierarchical tumor heterogeneity mediated by cell contact between distinct genetic subclones. PMID:33529175
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. PMID:33529165
Brahma-Related Gene-1 (BRG1) promotes the malignant phenotype of glioblastoma cells. PMID:33528916
Transcriptional E2F1/2/3/6 as potential prognostic biomarkers in cutaneous melanoma. PMID:33527034
CARD11 alteration as a candidate biomarker of skin cutaneous melanoma treated with immune checkpoint blockade. PMID:33527024
Proteasomal Regulation of Mammalian SPT16 in Controlling Transcription. PMID:33526453
Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling. PMID:33526450
Reuse of Molecules for Glioblastoma Therapy. PMID:33525329
NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription. PMID:33520407
Epigenetically silenced linc00261 contributes to the metastasis of hepatocellular carcinoma via inducing the deficiency of FOXA2 transcription. PMID:33520374
Generating Ensembles of Gene Regulatory Networks to Assess Robustness of Disease Modules. PMID:33519907
Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding. PMID:33515600
The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo. PMID:33514834
My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype. PMID:33514395
Restoring the DREAM Complex Inhibits the Proliferation of High-Risk HPV Positive Human Cells. PMID:33513914
Integrin α3β1 Promotes Invasive and Metastatic Properties of Breast Cancer Cells through Induction of the Brn-2 Transcription Factor. PMID:33513758
Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors. PMID:33513287
ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models. PMID:33512452
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer. PMID:33509944
Therapeutic Implications of Detecting MAPK-Activating Alterations in Cutaneous and Unknown Primary Melanomas. PMID:33509808
Molecular and immune signature of HPV-positive oral cavity squamous cell carcinoma. PMID:33509683
OIP5-AS1 specifies p53-driven POX transcription regulated by TRPC6 in glioma. PMID:33508123
Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases. PMID:33507258
Dissecting the Invasion-Associated Long Non-coding RNAs Using Single-Cell RNA-Seq Data of Glioblastoma. PMID:33505440
Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression. PMID:33504618
Cancer of Unknown Primary: Challenges and Progress in Clinical Management. PMID:33504059
K3326X and Other C-Terminal BRCA2 Variants Implicated in Hereditary Cancer Syndromes: A Review. PMID:33503928
Development of a prognostic index based on immunogenomic landscape analysis in glioma. PMID:33503296
PHLPPing the balance: restoration of protein kinase C in cancer. PMID:33502516
High LARGE1 Expression May Predict Benefit from Adjuvant Chemotherapy in Resected Non-Small-Cell Lung Cancer. PMID:33500650
Effective Prediction of Prostate Cancer Recurrence through the IQGAP1 Network. PMID:33498739
Nexus between PI3K/AKT and Estrogen Receptor Signaling in Breast Cancer. PMID:33498407
RSF1 requires CEBP/β and hSNF2H to promote IL-1β-mediated angiogenesis: the clinical and therapeutic relevance of RSF1 overexpression and amplification in myxofibrosarcomas. PMID:33496909
An improved assay for detection of theranostic gene translocations and MET exon 14 skipping in thoracic oncology. PMID:33495574
TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin. PMID:33495197
Immune Resistance in Lung Adenocarcinoma. PMID:33494181
IPPC: an interactive platform for prostate cancer multi-omics data integration and analysis. PMID:33493265
Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers. PMID:33493140
Expression and prognostic analyses of SCAMPs in pancreatic adenocarcinoma. PMID:33493138
Genomic alterations predictive of response to radiosurgery in recurrent IDH-WT glioblastoma. PMID:33492602
COL1A1 Is a Potential Prognostic Biomarker and Correlated with Immune Infiltration in Mesothelioma. PMID:33490271
Analysis of the Prognosis and Therapeutic Value of the CXC Chemokine Family in Head and Neck Squamous Cell Carcinoma. PMID:33489879
BRAF AMP Frequently Co-occurs With IDH1/2, TP53, and ATRX Mutations in Adult Patients With Gliomas and Is Associated With Poorer Survival Than That of Patients Harboring BRAF V600E. PMID:33489866
KYNU, a novel potential target that underpins CD44-promoted breast tumour cell invasion. PMID:33486887
Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia. PMID:33485366
The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer. PMID:33483585
Online informatics resources to facilitate cancer target and chemical probe discovery. PMID:33479663
L-Selectin expression is associated with inflammatory microenvironment and favourable prognosis in breast cancer. PMID:33479593
Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells. PMID:33475085
Liquid biopsy enters the clinic - implementation issues and future challenges. PMID:33473219
CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer. PMID:33471959
Identification of Prognostic Biomarkers and Molecular Targets Among JAK Family in Breast Cancer. PMID:33469338
Tumor infiltrating lymphocyte clusters are associated with response to immune checkpoint inhibition in BRAF V600E/K mutated malignant melanomas. PMID:33469107
Triple-Negative Breast Cancer and the COVID-19 Pandemic: Clinical Management Perspectives and Potential Consequences of Infection. PMID:33467411
The Taming of Nuclear Factor Erythroid-2-Related Factor-2 (Nrf2) Deglycation by Fructosamine-3-Kinase (FN3K)-Inhibitors-A Novel Strategy to Combat Cancers. PMID:33466626
Mechanisms of Resistance to KRASG12C Inhibitors. PMID:33466360
Molecular Changes in Retinoblastoma beyond RB1: Findings from Next-Generation Sequencing. PMID:33466343
A novel immunogenomic prognostic signature in lung squamous carcinoma. PMID:33466167
Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma. PMID:33461580
CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer. PMID:33461170
Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer. PMID:33457104
MRPL27 contributes to unfavorable overall survival and disease-free survival from cholangiocarcinoma patients. PMID:33456351
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair. PMID:33452241
Secretoglobin 3A2 eliminates human cancer cells through pyroptosis. PMID:33452234
AhR and Cancer: From Gene Profiling to Targeted Therapy. PMID:33451095
Correlation of genomic alterations and PD-L1 expression in thymoma. PMID:33447447
Genomic alterations in thymoma-molecular pathogenesis? PMID:33447444
CD117/c-kit defines a prostate CSC-like subpopulation driving progression and TKI resistance. PMID:33446896
Roles of the BAP1 Tumor Suppressor in Cell Metabolism. PMID:33446574
Characterization of SOX2, OCT4 and NANOG in Ovarian Cancer Tumor-Initiating Cells. PMID:33445692
Combined assay of Circulating Tumor DNA and Protein Biomarkers for early noninvasive detection and prognosis of Non-Small Cell Lung Cancer. PMID:33442424
Transcript levels of keratin 1/5/6/14/15/16/17 as potential prognostic indicators in melanoma patients. PMID:33441834
Lipid droplet biogenesis and COX-2 pathway activation are triggered by Barrett's esophagus and adenocarcinoma, but not esophageal squamous cell carcinoma risk factors. PMID:33441691
Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy. PMID:33441554
Integrate analysis of the promote function of Cell division cycle-associated protein family to pancreatic adenocarcinoma. PMID:33437202
A modular master regulator landscape controls cancer transcriptional identity. PMID:33434495
Cell-Intrinsic Tumorigenic Functions of PPARγ in Bladder Urothelial Carcinoma. PMID:33431608
XXYLT1 methylation contributes to the occurrence of lung adenocarcinoma: Methylation and lung adenocarcinoma. PMID:33429795
Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2). PMID:33428613
Relevance of STK11 Mutations Regarding Immune Cell Infiltration, Drug Sensitivity, and Cellular Processes in Lung Adenocarcinoma. PMID:33425731
Downregulation of Brain Enriched Type 2 MAGEs Is Associated With Immune Infiltration and Poor Prognosis in Glioma. PMID:33425727
PD-L1 and PD-L2 Expression in Cervical Cancer: Regulation and Biomarker Potential. PMID:33424844
A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance. PMID:33420373
Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype. PMID:33420368
EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma. PMID:33420027
Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy. PMID:33417860
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. PMID:33417831
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma. PMID:33414994
Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth. PMID:33414169
Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway. PMID:33412308
Integrated bioinformatic analysis of RNA binding proteins in hepatocellular carcinoma. PMID:33411682
Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation. PMID:33408774
Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer. PMID:33407715
Development of nomogram based on immune-related gene FGFR4 for advanced non-small cell lung cancer patients with sensitivity to immune checkpoint inhibitors. PMID:33407583
Construction of a nine DNA repair-related gene prognostic classifier to predict prognosis in patients with endometrial carcinoma. PMID:33407221
Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein. PMID:33405952
Prognostic implication of glycolysis related gene signature in non-small cell lung cancer. PMID:33403045
Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway. PMID:33403043
BRCA1/2 pathogenic variants in triple-negative versus luminal-like breast cancers: genotype-phenotype correlation in a cohort of 531 patients. PMID:33403015
Identification of a novel six autophagy-related genes signature for the prognostic and a miRNA-related autophagy predictor for anti-PD-1 therapy responses in prostate cancer. PMID:33402116
Pseudogene Annexin A2 Pseudogene 1 Contributes to Hepatocellular Carcinoma Progression by Modulating Its Parental Gene ANXA2 via miRNA-376a-3p. PMID:33398718
Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies. PMID:33398072
Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer. PMID:33397968
Targeting Lymphotoxin Beta and Paired Box 5: a potential therapeutic strategy for soft tissue sarcoma metastasis. PMID:33397394
The ITIM-Containing Receptor: Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) Modulates Immune Response and Confers Poor Prognosis in Invasive Breast Carcinoma. PMID:33396670
The Impact of Immunofunctional Phenotyping on the Malfunction of the Cancer Immunity Cycle in Breast Cancer. PMID:33396390
Cyclin-dependent Kinase 1 and Aurora Kinase choreograph mitotic storage and redistribution of a growth factor receptor. PMID:33395410
Interplay Between EGFR and the Platelet-Activating Factor/PAF Receptor Signaling Axis Mediates Aggressive Behavior of Cervical Cancer. PMID:33392068
Using The Cancer Genome Atlas as an Inquiry Tool in the Undergraduate Classroom. PMID:33391340
Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma. PMID:33390805
Discovery of acquired molecular signature on immune checkpoint inhibitors in paired tumor tissues. PMID:33389015
SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma. PMID:33387348
Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency. PMID:33385162
Functional Gene Expression Differentiation of the Notch Signaling Pathway in Female Reproductive Tract Tissues-A Comprehensive Review With Analysis. PMID:33384996
HOXA5 Expression Is Elevated in Breast Cancer and Is Transcriptionally Regulated by Estradiol. PMID:33384715
Genomic and transcriptomic landscape of conjunctival melanoma. PMID:33383577
Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer. PMID:33383310
HeartBioPortal2.0: new developments and updates for genetic ancestry and cardiometabolic quantitative traits in diverse human populations. PMID:33382884
Targeting BRD9 for Cancer Treatment: A New Strategy. PMID:33380808
USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells. PMID:33378683
Hypoxic exposure activates the B cell-specific Moloney murine leukaemia virus integration site 1/PI3K/Akt axis and promotes EMT in leukaemia stem cells. PMID:33376531
Effect of let-7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma. PMID:33376529
Characterizing TP53 mutations in ovarian carcinomas with and without concurrent BRCA1 or BRCA2 mutations. PMID:33375991
AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer? PMID:33375416
High Risk α-HPV E6 Impairs Translesion Synthesis by Blocking POLη Induction. PMID:33374731
Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma. PMID:33369458
Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes-Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans. PMID:33368437
Transcription factor networks of oligodendrogliomas treated with adjuvant radiotherapy or observation inform prognosis. PMID:33367753
m5C RNA Methylation Primarily Affects the ErbB and PI3K-Akt Signaling Pathways in Gastrointestinal Cancer. PMID:33365328
Overexpression of rhophilin 2 promotes pancreatic ductal adenocarcinoma. PMID:33365087
Systematic Analysis of Expression Profiles and Prognostic Significance for FAM83 Family in Non-small-Cell Lung Cancer. PMID:33363204
Beyond TNBC: Repositioning of Clofazimine Against a Broad Range of Wnt-Dependent Cancers. PMID:33363033
AUNIP Expression Is Correlated With Immune Infiltration and Is a Candidate Diagnostic and Prognostic Biomarker for Hepatocellular Carcinoma and Lung Adenocarcinoma. PMID:33363020
Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer. PMID:33363011
Alterations in TP53 Are a Potential Biomarker of Bladder Cancer Patients Who Benefit From Immune Checkpoint Inhibition. PMID:33356494
Molecular Network Profiling in Intestinal- and Diffuse-Type Gastric Cancer. PMID:33353109
AKR1C3 Is Associated with Better Survival of Patients with Endometrial Carcinomas. PMID:33352741
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification. PMID:33350495
Cytoskeletal Control and Wnt Signaling-APC's Dual Contributions in Stem Cell Division and Colorectal Cancer. PMID:33348689
Bioinformatics analysis identifies COL1A1, THBS2 and SPP1 as potential predictors of patient prognosis and immunotherapy response in gastric cancer. PMID:33345281
Identification of the Roles of Chromobox Family Members in Gastric Cancer: A Study Based on Multiple Datasets. PMID:33344640
Hypoxia-Associated Prognostic Markers and Competing Endogenous RNA Co-Expression Networks in Breast Cancer. PMID:33344235
Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer. PMID:33342055
Key pathways in prostate cancer with SPOP mutation identified by bioinformatic analysis. PMID:33336059
Attenuation of SRC Kinase Activity Augments PARP Inhibitor-mediated Synthetic Lethality in BRCA2-altered Prostate Tumors. PMID:33334906
A Critical Role for Fas-Mediated Off-Target Tumor Killing in T-cell Immunotherapy. PMID:33334730
The PARP Inhibitor Olaparib Modulates the Transcriptional Regulatory Networks of Long Non-Coding RNAs during Vasculogenic Mimicry. PMID:33333852
Prognostic Biomarker TP53 Mutations for Immune Checkpoint Blockade Therapy and Its Association With Tumor Microenvironment of Lung Adenocarcinoma. PMID:33330629
Increased NFATC4 Correlates With Poor Prognosis of AML Through Recruiting Regulatory T Cells. PMID:33329712
Drug Response Associated With and Prognostic lncRNAs Mediated by DNA Methylation and Transcription Factors in Colon Cancer. PMID:33329694
Identification of Mutated Peptides in Bladder Cancer From Exomic Sequencing Data Reveals Negative Correlation Between Mutation-Specific Immunoreactivity and Inflammation. PMID:33329543
Identification of Interleukin-9 Producing Immune Cells in Endometrial Carcinoma and Establishment of a Prognostic Nomogram. PMID:33329510
Oncology and Pharmacogenomics Insights in Polycystic Ovary Syndrome: An Integrative Analysis. PMID:33329391
FIREWORKS: a bottom-up approach to integrative coessentiality network analysis. PMID:33328249
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. PMID:33326793
Identification of Metabolism-Associated Prostate Cancer Subtypes and Construction of a Prognostic Risk Model. PMID:33324566
Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II-practical challenges. PMID:33323463
Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer. PMID:33322840
CDKN2A-Inactivated Pancreatic Ductal Adenocarcinoma Exhibits Therapeutic Sensitivity to Paclitaxel: A Bioinformatics Study. PMID:33322698
The Molecular 'Myc-anisms' Behind Myc-Driven Tumorigenesis and the Relevant Myc-Directed Therapeutics. PMID:33322239
Activation of the Ion Channel TRPV4 Induces Epithelial to Mesenchymal Transition in Breast Cancer Cells. PMID:33322037
Regulation of ST6GAL1 sialyltransferase expression in cancer cells. PMID:33320246
Prognostic value of intratumoral lymphocyte-to-monocyte ratio and M0 macrophage enrichment in tumor immune microenvironment of melanoma. PMID:33318782
Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity. PMID:33318037
Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres. PMID:33317554
Expression of PAWR predicts prognosis of ovarian cancer. PMID:33317551
Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells. PMID:33316932
A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death. PMID:33314700
Role of SPTSSB-Regulated de Novo Sphingolipid Synthesis in Prostate Cancer Depends on Androgen Receptor Signaling. PMID:33313495
CCTs as new biomarkers for the prognosis of head and neck squamous cancer. PMID:33313411
Genomic analysis of the prognostic effect of tumor-associated neutrophil-related genes across 15 solid cancer types: an immune perspective. PMID:33313252
Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma. PMID:33312955
Updates on "Cancer Genomics and Epigenomics". PMID:33312884
Circulating tumor DNA analysis of metastatic renal cell carcinoma. PMID:33312563
Targeted massively parallel sequencing of mature lymphoid neoplasms: assessment of empirical application and diagnostic utility in routine clinical practice. PMID:33311649
Intron retention is a robust marker of intertumoral heterogeneity in pancreatic ductal adenocarcinoma. PMID:33311498
Differential genetic mutations of ectoderm, mesoderm, and endoderm-derived tumors in TCGA database. PMID:33308219
A Gene Mutation Signature Predicting Immunotherapy Benefits in Patients With NSCLC. PMID:33307194
SPRED1 deletion confers resistance to MAPK inhibition in melanoma. PMID:33306107
Computational methods for detecting cancer hotspots. PMID:33304455
M1 Polarization Markers Are Upregulated in Basal-Like Breast Cancer Molecular Subtype and Associated With Favorable Patient Outcome. PMID:33304345
The conformational and mutational landscape of the ubiquitin-like marker for autophagosome formation in cancer. PMID:33302793
Angiogenesis-Related Gene Expression Signatures Predicting Prognosis in Gastric Cancer Patients. PMID:33302481
The role of the SWI/SNF chromatin remodeling complex in pancreatic ductal adenocarcinoma. PMID:33301642
A metastasis map of human cancer cell lines. PMID:33299191
Genomic investigation of co-targeting tumor immune microenvironment and immune checkpoints in pan-cancer immunotherapy. PMID:33299118
BMP signaling is a therapeutic target in ovarian cancer. PMID:33298901
The ZNF750-RAC1 axis as potential prognostic factor for breast cancer. PMID:33298895
Identification of Genes Required for Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells In Vitro. PMID:33298586
Human Papillomavirus 16 (HPV16) E2 Repression of TWIST1 Transcription Is a Potential Mediator of HPV16 Cancer Outcomes. PMID:33298572
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer. PMID:33298139
Multi-Omics Analysis Identifying Key Biomarkers in Ovarian Cancer. PMID:33297760
Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer. PMID:33294279
MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role. PMID:33293474
Recurrent SETD2 mutation in NPM1-mutated acute myeloid leukemia. PMID:33292784
Assessing immune infiltration and the tumor microenvironment for the diagnosis and prognosis of sarcoma. PMID:33292275
Evaluation of Clinicopathological and Molecular Parameters on Disease Recurrence of Papillary Thyroid Cancer Patient: A Retrospective Observational Study. PMID:33291668
Identification of "regulation of RhoA activity panel" as a prognostic and predictive biomarker for gastric cancer. PMID:33288739
The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma. PMID:33287763
Identification of a four-gene panel predicting overall survival for lung adenocarcinoma. PMID:33287749
Focus on DNA Glycosylases-A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets. PMID:33287345
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer. PMID:33282948
β-hydroxybutyrate does not alter the effects of glucose deprivation on breast cancer cells. PMID:33281976
PARPBP is a prognostic marker and confers anthracycline resistance to breast cancer. PMID:33281951
Immune-Related Gene-Based Novel Subtypes to Establish a Model Predicting the Risk of Prostate Cancer. PMID:33281882
SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence. PMID:33277667
An integrated approach to biomarker discovery reveals gene signatures highly predictive of cancer progression. PMID:33277589
NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis. PMID:33276631
Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration-resistant prostate cancer. PMID:33275817
A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3. PMID:33273692
Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma. PMID:33272983
Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas. PMID:33271120
Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors. PMID:33270827
G Protein-Coupled receptors and heterotrimeric G proteins as cancer drivers. PMID:33270228
The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer. PMID:33270085
Oncogenic Roles of RAD51AP1 in Tumor Tissues Related to Overall Survival and Disease-Free Survival in Hepatocellular Carcinoma. PMID:33269607
Multi-Omics Database Analysis of Aminoacyl-tRNA Synthetases in Cancer. PMID:33266490
Construction of a Novel Multigene Panel Potently Predicting Poor Prognosis in Patients with Clear Cell Renal Cell Carcinoma. PMID:33266355
Differential Effects of Cancer-Associated Mutations Enriched in Helix H3 of PPARγ. PMID:33266062
Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer. PMID:33264619
Exome sequencing identifies ARID2 as a novel tumor suppressor in early-onset sporadic rectal cancer. PMID:33262464
Functional characterization of uveal melanoma oncogenes. PMID:33262460
Degree of Early Estrogen Response Predict Survival after Endocrine Therapy in Primary and Metastatic ER-Positive Breast Cancer. PMID:33260779
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression. PMID:33257795
ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin's lymphoma and testicular cancer cells. PMID:33257682
Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups. PMID:33256706
Lectin-Like Transcript 1 (LLT1) Checkpoint: A Novel Independent Prognostic Factor in HPV-Negative Oropharyngeal Squamous Cell Carcinoma. PMID:33255617
TET2/IDH1/2/WT1 and NPM1 Mutations Influence the RUNX1 Expression Correlations in Acute Myeloid Leukemia. PMID:33255417
Effective RNA Knockdown Using CRISPR-Cas13a and Molecular Targeting of the EML4-ALK Transcript in H3122 Lung Cancer Cells. PMID:33255340
Targeted Sequencing of Pancreatic Adenocarcinomas from Patients with Metachronous Pulmonary Metastases. PMID:33255265
Identification of potential biomarkers for lung adenocarcinoma. PMID:33251353
VarStack: a web tool for data retrieval to interpret somatic variants in cancer. PMID:33247936
Overexpression of BASP1 Indicates a Poor Prognosis in Head and Neck Squamous Cell Carcinoma. PMID:33247706
c-KIT-ERK1/2 signaling activated ELK1 and upregulated carcinoembryonic antigen expression to promote colorectal cancer progression. PMID:33247506
Premature termination codons in SOD1 causing Amyotrophic Lateral Sclerosis are predicted to escape the nonsense-mediated mRNA decay. PMID:33244158
Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics. PMID:33244070
Lower mutant-allele tumor heterogeneity is a biomarker in FGFR3-mutant bladder cancer for better prognosis. PMID:33243261
The discovery of AVIL as a bona fide oncogene in glioblastoma. PMID:33241106
CDK5 Inhibition Abrogates TNBC Stem-Cell Property and Enhances Anti-PD-1 Therapy. PMID:33240752
Improving existing analysis pipeline to identify and analyze cancer driver genes using multi-omics data. PMID:33239644
Prognostic Value of Gastrokine-2 (GKN2) and Its Correlation with Tumor-Infiltrating Immune Cells in Lung Cancer and Gastric Cancers. PMID:33235482
Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells. PMID:33232921
Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis. PMID:33232824
Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. PMID:33232662
Discovering novel driver mutations from pan-cancer analysis of mutational and gene expression profiles. PMID:33232371
Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer. PMID:33231569
Pan-cancer methylation analysis reveals an inverse correlation of tumor immunogenicity with methylation aberrancy. PMID:33230567
Identification of transcription factor co-regulators that drive prostate cancer progression. PMID:33230156
SWI/SNF Alterations in Squamous Bladder Cancers. PMID:33227989
Clinicopathological and immunological characterization of RNA m6 A methylation regulators in ovarian cancer. PMID:33225598
A Clinical Genomics-Guided Prioritizing Strategy Enables Selecting Proper Cancer Cell Lines for Biomedical Research. PMID:33225250
Cell Plasticity-Related Phenotypes and Taxanes Resistance in Castration-Resistant Prostate Cancer. PMID:33224888
In Search of TGCT Biomarkers: A Comprehensive In Silico and Histopathological Analysis. PMID:33224314
Clinical and molecular distinctions in patients with refractory colon cancer who benefit from regorafenib treatment. PMID:33224274
FGFR3 Alterations in the Era of Immunotherapy for Urothelial Bladder Cancer. PMID:33224141
Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma. PMID:33223751
A novel miRNA inhibits metastasis of prostate cancer via decreasing CREBBP-mediated histone acetylation. PMID:33221996
CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer. PMID:33218188
Genetic Mutations and Variants in the Susceptibility of Familial Non-Medullary Thyroid Cancer. PMID:33218058
Genomic Amplification and Functional Dependency of the Gamma Actin Gene ACTG1 in Uterine Cancer. PMID:33217970
MEK is a promising target in the basal subtype of bladder cancer. PMID:33216841
Frequency and prognostic value of mutations associated with the homologous recombination DNA repair pathway in a large pan cancer cohort. PMID:33214570
Integrated Multi-Tumor Radio-Genomic Marker of Outcomes in Patients with High Serous Ovarian Carcinoma. PMID:33212885
Functional role of vitronectin in breast cancer. PMID:33211735
Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA. PMID:33210317
Angiogenesis related gene expression significantly associated with the prognostic role of an urothelial bladder carcinoma. PMID:33209684
Upregulation of ERCC6L is associated with tumor progression and unfavorable prognosis in hepatocellular carcinoma. PMID:33209494
Expression and prognostic value of Chromobox family members in gastric cancer. PMID:33209492
Comprehensive analysis of the prognosis for chromobox family in gastric cancer. PMID:33209489
The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer. PMID:33205077
Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality. PMID:33205017
A prognostic risk model based on immune-related genes predicts overall survival of patients with hepatocellular carcinoma. PMID:33204848
Somatic mutational landscapes of adherens junctions and their functional consequences in cutaneous melanoma development. PMID:33204327
TP53 mutations and CDKN2A mutations/deletions are highly recurrent molecular alterations in the malignant progression of sinonasal papillomas. PMID:33203919
ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL. PMID:33203881
Cancer Stem Cells and the Slow Cycling Phenotype: How to Cut the Gordian Knot Driving Resistance to Therapy in Melanoma. PMID:33202944
USP25 Regulates EGFR Fate by Modulating EGF-Induced Ubiquitylation Dynamics. PMID:33202887
Biomarker Development for Metastatic Renal Cell Carcinoma: Omics, Antigens, T-cells, and Beyond. PMID:33202724
Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer. PMID:33199492
EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers. PMID:33199443
E3 Ubiquitin Ligase TRIP12: Regulation, Structure, and Physiopathological Functions. PMID:33198194
Plasmacytoid Dendritic Cell (pDC) Infiltration Correlate with Tumor Infiltrating Lymphocytes, Cancer Immunity, and Better Survival in Triple Negative Breast Cancer (TNBC) More Strongly than Conventional Dendritic Cell (cDC). PMID:33198125
Mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon: detailed molecular characterisation of two cases indicates a distinct colorectal cancer entity. PMID:33197299
CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics. PMID:33196823
PAXX, Not NHEJ1 Is an Independent Prognosticator in Colon Cancer. PMID:33195430
The Landscape of Coronavirus Disease 2019 (COVID-19) and Integrated Analysis SARS-CoV-2 Receptors and Potential Inhibitors in Lung Adenocarcinoma Patients. PMID:33195212
Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter? PMID:33194757
Molecular and Clinical Characterization of a Novel Prognostic and Immunologic Biomarker FAM111A in Diffuse Lower-Grade Glioma. PMID:33194678
The Resistance Mechanisms of Lung Cancer Immunotherapy. PMID:33194652
Development and validation of a survival model based on autophagy-associated genes for predicting prognosis of hepatocellular carcinoma. PMID:33194067
Integration of Online Omics-Data Resources for Cancer Research. PMID:33193699
Multi-Omics Analysis Detects Novel Prognostic Subgroups of Breast Cancer. PMID:33193681
Theoretical and in silico Analyses Reveal MYC as a Dynamic Network Biomarker in Colon and Rectal Cancer. PMID:33193630
Data mining combined with experiments to validate CEP55 as a prognostic biomarker in colorectal cancer. PMID:33190424
Prognostic roles of metabolic reprogramming-associated genes in patients with hepatocellular carcinoma. PMID:33188160
SLX4IP Promotes Telomere Maintenance in Androgen Receptor-Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization. PMID:33188147
A Targeted Bioinformatics Assessment of Adrenocortical Carcinoma Reveals Prognostic Implications of GABA System Gene Expression. PMID:33187258
Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq. PMID:33184288
Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival. PMID:33182511
Spectrum of Mesenchymal-Epithelial Transition Aberrations and Potential Clinical Implications: Insights From Integrative Pancancer Analysis. PMID:33178590
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer. PMID:33177715
PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways. PMID:33177155
5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts. PMID:33176741
HNF1B inhibits cell proliferation via repression of SMAD6 expression in prostate cancer. PMID:33174391
Combination of lysine-specific demethylase 6A (KDM6A) and mismatch repair (MMR) status is a potential prognostic factor in colorectal cancer. PMID:33174323
Integrative Analysis of HNF1B mRNA in Human Cancers Based on Data Mining. PMID:33173410
Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing. PMID:33173047
Cold-inducible RNA binding protein promotes breast cancer cell malignancy by regulating Cystatin C levels. PMID:33172965
Clinical and mutational profiles of adult medulloblastoma groups. PMID:33172502
Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis. PMID:33172155
Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells. PMID:33171110
Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions. PMID:33168106
EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer. PMID:33167919
Potential roles of PBRM1 on immune infiltration in cholangiocarcinoma. PMID:33165423
Isocitrate dehydrogenase 3A, a rate-limiting enzyme of the TCA cycle, promotes hepatocellular carcinoma migration and invasion through regulation of MTA1, a core component of the NuRD complex. PMID:33163266
Roles for the FCRL6 Immunoreceptor in Tumor Immunology. PMID:33162991
HCK can serve as novel prognostic biomarker and therapeutic target for Breast Cancer patients. PMID:33162805
Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA. PMID:33161228
Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome. PMID:33158447
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. PMID:33157015
Early Gastric Cancer: identification of molecular markers able to distinguish submucosa-penetrating lesions with different prognosis. PMID:33156452
Overexpression of Rhophilin Rho GTPase-binding protein 2 promotes hepatocellular carcinoma. PMID:33154780
Characterization of Mutational Status, Spheroid Formation, and Drug Response of a New Genomically-Stable Human Ovarian Clear Cell Carcinoma Cell Line, 105C. PMID:33153119
Differential Expression of PEG10 Contributes to Aggressive Disease in Early Versus Late-Onset Colorectal Cancer. PMID:33149023
Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells. PMID:33148662
Neuroendocrine tumours of the breast: a genomic comparison with mucinous breast cancers and neuroendocrine tumours of other anatomic sites. PMID:33148628
Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations. PMID:33147938
Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment. PMID:33146700
Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion. PMID:33144694
Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients. PMID:33144586
"Serine and One-Carbon Metabolism in Breast Cancer Metastasis"-Letter. PMID:33144383
GBAF, a small BAF sub-complex with big implications: a systematic review. PMID:33143733
Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer. PMID:33142117
Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47phox. PMID:33139577
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status. PMID:33138032
Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation. PMID:33137094
netboxr: Automated discovery of biological process modules by network analysis in R. PMID:33137091
Characterization of the Tumor Immune Microenvironment Identifies M0 Macrophage-Enriched Cluster as a Poor Prognostic Factor in Hepatocellular Carcinoma. PMID:33136432
TERT promoter mutation associated with multifocal phenotype and poor prognosis in patients with IDH wild-type glioblastoma. PMID:33134923
Crosstalk Between MYC and lncRNAs in Hematological Malignancies. PMID:33134177
Chaperones and Ubiquitin Ligases Balance Mutant p53 Protein Stability in Esophageal and Other Digestive Cancers. PMID:33130332
TIM3 expression on tumor cells predicts response to anti-PD-1 therapy for renal cancer. PMID:33129110
Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression. PMID:33127842
Trametinib Induces the Stabilization of a Dual GNAQ p.Gly48Leu- and FGFR4 p.Cys172Gly-Mutated Uveal Melanoma. The Role of Molecular Modelling in Personalized Oncology. PMID:33126538
YAP/TAZ Signalling in Colorectal Cancer: Lessons from Consensus Molecular Subtypes. PMID:33126419
Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state. PMID:33125139
Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia. PMID:33123685
ATP6AP2 is Overexpressed in Breast Cancer and Promotes Breast Cancer Progression. PMID:33122944
Screening and identification of key genes and pathways in metastatic uveal melanoma based on gene expression using bioinformatic analysis. PMID:33120861
Multiomic Integration of Public Oncology Databases in Bioconductor. PMID:33119407
Comprehensive Analysis of Prognostic Markers for Acute Myeloid Leukemia Based on Four Metabolic Genes. PMID:33117716
TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L. PMID:33115448
Non-Canonical Functions of the Gamma-Tubulin Meshwork in the Regulation of the Nuclear Architecture. PMID:33114224
USP1 Regulates TAZ Protein Stability Through Ubiquitin Modifications in Breast Cancer. PMID:33114077
Comprehensive analysis of the expression of SLC30A family genes and prognosis in human gastric cancer. PMID:33110097
Naturally occurring hotspot cancer mutations in Gα13 promote oncogenic signaling. PMID:33109615
WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer. PMID:33109540
Functional and genomic characterization of patient-derived xenograft model to study the adaptation to mTORC1 inhibitor in clear cell renal cell carcinoma. PMID:33107222
RNA-binding protein DDX3 mediates posttranscriptional regulation of androgen receptor: A mechanism of castration resistance. PMID:33106406
Prognostic Significance of Oxidation Pathway Mutations in Recurrent Laryngeal Squamous Cell Carcinoma. PMID:33105726
MN1 overexpression with varying tumor grade is a promising predictor of survival of glioma patients. PMID:33105486
Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis. PMID:33102693
DEC2 Serves as Potential Tumor Suppressor in Breast Carcinoma. PMID:33101542
Small interfering RNA-mediated knockdown of KRT80 suppresses colorectal cancer proliferation. PMID:33101466
Development and Validation of an Immune-Related lncRNA Signature for Predicting the Prognosis of Hepatocellular Carcinoma. PMID:33101369
Emerging epigenetic therapeutics for myeloid leukemia: modulating demethylase activity with ascorbate. PMID:33099992
Functional network analysis reveals potential repurposing of β-blocker atenolol for pancreatic cancer therapy. PMID:33098056
Mutations and mechanisms of WNT pathway tumour suppressors in cancer. PMID:33097916
Keap1 inhibition sensitizes head and neck squamous cell carcinoma cells to ionizing radiation via impaired non-homologous end joining and induced autophagy. PMID:33087706
Abundance of Regulatory T Cell (Treg) as a Predictive Biomarker for Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer. PMID:33086518
A Bioinformatic Pipeline Places STAT5A as a miR-650 Target in Poorly Differentiated Aggressive Breast Cancer. PMID:33086498
CKS2 and RMI2 are two prognostic biomarkers of lung adenocarcinoma. PMID:33083148
Validation and clinical application of a targeted next-generation sequencing gene panel for solid and hematologic malignancies. PMID:33083132
Bioinformatic analysis of the expression and prognostic value of chromobox family proteins in human breast cancer. PMID:33082469
Inhibiting insulin and mTOR signaling by afatinib and crizotinib combination fosters broad cytotoxic effects in cutaneous malignant melanoma. PMID:33082316
Multiomics integrative analysis for gene signatures and prognostic values of m6A regulators in pancreatic adenocarcinoma: a retrospective study in The Cancer Genome Atlas project. PMID:33082301
Common gene signatures and key pathways in hypopharyngeal and esophageal squamous cell carcinoma: Evidence from bioinformatic analysis. PMID:33080677
Cytosolic pH regulates proliferation and tumour growth by promoting expression of cyclin D1. PMID:33077976
Melanoma Stem Cell-Like Phenotype and Significant Suppression of Immune Response within a Tumor Are Regulated by TRIM28 Protein. PMID:33076560
Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression. PMID:33076392
SWI/SNF inactivation in the endometrial epithelium leads to loss of epithelial integrity. PMID:33075803
The prognostic significance of interferon-stimulated gene 15 (ISG15) in invasive breast cancer. PMID:33073304
RUNX2 interacts with BRG1 to target CD44 for promoting invasion and migration of colorectal cancer cells. PMID:33071648
Sunitinib in Patients with Metastatic Colorectal Cancer (mCRC) with FLT-3 Amplification: Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) Study. PMID:33068284
Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity. PMID:33067454
CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer. PMID:33066224
Gene amplification of YB-1 in castration-resistant prostate cancer in association with aberrant androgen receptor expression. PMID:33064355
MEK inhibition activates STAT signaling to increase breast cancer immunogenicity via MHC-I expression. PMID:33062958
Interactive Verification Analysis of Multiple Sequencing Data for Identifying Potential Biomarker of Lung Adenocarcinoma. PMID:33062704
Association Between Succinate Receptor SUCNR1 Expression and Immune Infiltrates in Ovarian Cancer. PMID:33062639
The role of m6A-related genes in the prognosis and immune microenvironment of pancreatic adenocarcinoma. PMID:33062408
Novel sequential treatment with palbociclib enhances the effect of cisplatin in RB-proficient triple-negative breast cancer. PMID:33061853
Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patients. PMID:33061814
Oleate acid-stimulated HMMR expression by CEBPα is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma. PMID:33061798
Identification and characterization of functional long noncoding RNAs in cancer. PMID:33058262
TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML. PMID:33057635
Clinical characteristics and prognostic implications of BRCA-associated tumors in males: a pan-tumor survey. PMID:33054725
Comprehensive Exome Analysis of Immunocompetent Metastatic Head and Neck Cancer Models Reveals Patient Relevant Landscapes. PMID:33053752
Estrogen Regulation of mTOR Signaling and Mitochondrial Function in Invasive Lobular Carcinoma Cell Lines Requires WNT4. PMID:33053661
In silico investigation of heparanase-correlated genes in breast cancer subtypes. PMID:33053017
POC1A acts as a promising prognostic biomarker associated with high tumor immune cell infiltration in gastric cancer. PMID:33052878
Characterization of the expression and prognostic value of 14-3-3 isoforms in breast cancer. PMID:33052135
Genotype-Phenotype Features of Germline Variants of the TMEM127 Pheochromocytoma Susceptibility Gene: A 10-Year Update. PMID:33051659
Clinicopathologic significance of protein lysine methyltransferases in cancer. PMID:33050946
Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors. PMID:33050470
Inhibition of ACK1 delays and overcomes acquired resistance of EGFR mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib. PMID:33049499
A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC. PMID:33049034
Identification of a prognostic gene signature based on an immunogenomic landscape analysis of bladder cancer. PMID:33048468
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD). PMID:33046988
Loss of ACSM3 confers worsened prognosis and immune exclusion to cutaneous melanoma. PMID:33046979
Deubiquitinase PSMD7 regulates cell fate and is associated with disease progression in breast cancer. PMID:33042429
Comprehensive characterization of functional eRNAs in lung adenocarcinoma reveals novel regulators and a prognosis-related molecular subtype. PMID:33042282
Association between copy-number alteration of +20q, -14q and -18p and cross-sensitivity to tyrosine kinase inhibitors in clear-cell renal cell carcinoma. PMID:33041663
Inhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer. PMID:33041328
CUP-AI-Dx: A tool for inferring cancer tissue of origin and molecular subtype using RNA gene-expression data and artificial intelligence. PMID:33039710
Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression. PMID:33039351
Spliceosomal factor mutations and mis-splicing in MDS. PMID:33038983
Allele-Specific Role of ERBB2 in the Oncogenic Function of EGFR L861Q in EGFR-Mutant Lung Cancers. PMID:33038514
Bioinformatic Identification of Potential Hub Genes in Muscle-Invasive Bladder Urothelial Carcinoma. PMID:33035117
Identification of a new pseudogenes/lncRNAs-hsa-miR-26b-5p-COL12A1 competing endogenous RNA network associated with prognosis of pancreatic cancer using bioinformatics analysis. PMID:33027767
ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells. PMID:33024871
Computational assessment of MCM2 transcriptional expression and identification of the prognostic biomarker for human breast cancer. PMID:33024849
Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome. PMID:33020491
Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. PMID:33020180
Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors. PMID:33016929
Identification of TYROBP and C1QB as Two Novel Key Genes With Prognostic Value in Gastric Cancer by Network Analysis. PMID:33014868
Discoidin Domain Receptors in Melanoma: Potential Therapeutic Targets to Overcome MAPK Inhibitor Resistance. PMID:33014862
Serpin peptidase inhibitor clade A member 1-overexpression in gastric cancer promotes tumor progression in vitro and is associated with poor prognosis. PMID:33014156
Knockdown of CSNK2ß suppresses MDA-MB231 cell growth, induces apoptosis, inhibits migration and invasion. PMID:33013272
Additional genetic alterations in BRAF-mutant gliomas correlate with histologic diagnoses. PMID:33009979
Biopathological Significance of PIWI-piRNA Pathway Deregulation in Invasive Breast Carcinomas. PMID:33008024
Transcriptome Profiling Reveals New Insights into the Immune Microenvironment and Upregulation of Novel Biomarkers in Metastatic Uveal Melanoma. PMID:33008022
MicroRNA-31 Regulates Expression of Wntless in Both Drosophila melanogaster and Human Oral Cancer Cells. PMID:33007980
Identification of Plasma Glycosphingolipids as Potential Biomarkers for Prostate Cancer (PCa) Status. PMID:33007922
Inflammatory Breast Cancer: Clinical Implications of Genomic Alterations and Mutational Profiling. PMID:33007869
Secretion of pro-oncogenic AGR2 protein in cancer. PMID:33005802
Regulating Methylation at H3K27: A Trick or Treat for Cancer Cell Plasticity. PMID:33003334
T follicular helper phenotype predicts response to histone deacetylase inhibitors in relapsed/refractory peripheral T-cell lymphoma. PMID:33002132
Role of serine 365 in BRAF V600E sensitivity to RAF inhibition. PMID:33000894
Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer. PMID:32999000
Omics-Based Platforms: Current Status and Potential Use for Cholangiocarcinoma. PMID:32998289
Two Sides of the Same Coin: The Roles of KLF6 in Physiology and Pathophysiology. PMID:32998281
The authors reply: Comment on "The expression landscape of cachexia-inducing factors in human cancers" by Freire et al. PMID:32996709
ITPKC as a Prognostic and Predictive Biomarker of Neoadjuvant Chemotherapy for Triple Negative Breast Cancer. PMID:32992708
Comprehensive Analysis of the Expression and Prognosis for SFRPs in Breast Carcinoma. PMID:32990024
Loss of UTX/KDM6A and the activation of FGFR3 converge to regulate differentiation gene-expression programs in bladder cancer. PMID:32989154
Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer. PMID:32988402
Beyond Traditional Morphological Characterization of Lung Neuroendocrine Neoplasms: In Silico Study of Next-Generation Sequencing Mutations Analysis across the Four World Health Organization Defined Groups. PMID:32987854
Role of POT1 in Human Cancer. PMID:32987645
Integrative Bioinformatics Analysis Reveals Potential Target Genes and TNFα Signaling Inhibition by Brazilin in Metastatic Breast Cancer Cells. PMID:32986377
The Construction of Bone Metastasis-Specific Prognostic Model and Co-expressed Network of Alternative Splicing in Breast Cancer. PMID:32984314
Complement C7 (C7), a Potential Tumor Suppressor, Is an Immune-Related Prognostic Biomarker in Prostate Cancer (PC). PMID:32984006
Enhanced Anticancer Effect of a Combination of S-adenosylmethionine (SAM) and Immune Checkpoint Inhibitor (ICPi) in a Syngeneic Mouse Model of Advanced Melanoma. PMID:32983966
Favorable Immune Microenvironment in Patients with EGFR and MAPK Co-Mutations. PMID:32982525
Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C. PMID:32980867
Overexpression of wild type or a Q311E mutant MB21D2 promotes a pro-oncogenic phenotype in HNSCC. PMID:32979859
Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz. PMID:32978601
EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer. PMID:32978523
Intrahepatic cholangiocarcinomas with IDH1/2 mutation-associated hypermethylation at selective genes and their clinicopathological features. PMID:32978444
Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor. PMID:32978388
A single-cell survey of cellular hierarchy in acute myeloid leukemia. PMID:32977829
Next-Generation Analytics for Omics Data. PMID:32976776
Multiple Chromoanasynthesis in a Rare Case of Sporadic Renal Leiomyosarcoma: A Case Report. PMID:32974204
Mutational Landscape of Esophageal Squamous Cell Carcinoma in an Indian Cohort. PMID:32974170
Comparison of Stage 4 and Stage 4s Neuroblastoma Identifies Autophagy-Related Gene and LncRNA Signatures Associated With Prognosis. PMID:32974147
Systemic Expression Analysis Reveals Prognostic Significance of WIPI3 in Hepatocellular Carcinoma. PMID:32973867
Comprehensive analysis on the expression levels and prognostic values of LOX family genes in kidney renal clear cell carcinoma. PMID:32970930
Prognostic landscape of tumor-infiltrating immune cells and immune-related genes in the tumor microenvironment of gastric cancer. PMID:32969836
Identification of diagnostic and prognostic biomarkers, and candidate targeted agents for hepatitis B virus-associated early stage hepatocellular carcinoma based on RNA-sequencing data. PMID:32968453
USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress. PMID:32968046
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. PMID:32966766
Multi-scale supervised clustering-based feature selection for tumor classification and identification of biomarkers and targets on genomic data. PMID:32962626
Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer. PMID:32962246
The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer. PMID:32957504
Targeting protein tyrosine kinase 6 in cancer. PMID:32956764
Analysis, identification and visualization of subgroups in genomics. PMID:32954413
Novel Potential Therapeutic Target for E2F1 and Prognostic Factors of E2F1/2/3/5/7/8 in Human Gastric Cancer. PMID:32953933
Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma. PMID:32951278
Association of PD-L1 and IDO1 expression with JAK-STAT pathway activation in soft-tissue leiomyosarcoma. PMID:32951108
Bioinformatics Data Mining Repurposes the JAK2 (Janus Kinase 2) Inhibitor Fedratinib for Treating Pancreatic Ductal Adenocarcinoma by Reversing the KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog)-Driven Gene Signature. PMID:32947833
Apolipoprotein C2 - CD36 Promotes Leukemia Growth and Presents a Targetable Axis in Acute Myeloid Leukemia. PMID:32944714
The critical role of BAP1 mutation in the prognosis and treatment selection of kidney renal clear cell carcinoma. PMID:32944533
N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours. PMID:32942614
Expression signature, prognosis value, and immune characteristics of Siglec-15 identified by pan-cancer analysis. PMID:32939323
Role of GATA3 exon 6 germline mutations in breast cancer progression in Egyptian female patients. PMID:32938228
Identification, Validation, and Functional Annotations of Genome-Wide Profile Variation between Melanocytic Nevus and Malignant Melanoma. PMID:32934956
Down syndrome iPSC model: endothelial perspective on tumor development. PMID:32934781
Identification of Key Prognostic Biomarker and Its Correlation with Immune Infiltrates in Pancreatic Ductal Adenocarcinoma. PMID:32934754
TMEM206 is a potential prognostic marker of hepatocellular carcinoma. PMID:32934741
Breast Cancer Cell Detection and Characterization from Breast Milk-Derived Cells. PMID:32934021
Intra-Tumoral Angiogenesis Is Associated with Inflammation, Immune Reaction and Metastatic Recurrence in Breast Cancer. PMID:32933189
FAM64A: A Novel Oncogenic Target of Lung Adenocarcinoma Regulated by Both Strands of miR-99a (miR-99a-5p and miR-99a-3p). PMID:32932948
Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis. PMID:32932846
Distinct cell-types in the prostate share an aging signature suggestive of metabolic reprogramming. PMID:32929410
Genome and transcriptome profiling of FBXW family in human prostate cancer. PMID:32929407
Triple Aberrant Prostate Cancer (TAPC) - Aggregate role of aberrations in TP53, PTEN and RB1 on ETS gene fusions and prognosis in metastatic castrate resistant prostate cancer. PMID:32929406
Tumor immune profiles noninvasively estimated by FDG PET with deep learning correlate with immunotherapy response in lung adenocarcinoma. PMID:32929383
EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy. PMID:32929368
HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma. PMID:32929358
Identification of glycogene-type and validation of ST3GAL6 as a biomarker predicts clinical outcome and cancer cell invasion in urinary bladder cancer. PMID:32929335
Histopathological imaging features- versus molecular measurements-based cancer prognosis modeling. PMID:32929170
Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney. PMID:32928875
HLA Class I Binding of Mutant EGFR Peptides in NSCLC Is Associated With Improved Survival. PMID:32927123
The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome. PMID:32926574
TENET 2.0: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma. PMID:32925947
Response of Brain Metastases From PIK3CA-Mutant Breast Cancer to Alpelisib. PMID:32923889
Comparison of Annotation Services for Next-Generation Sequencing in a Large-Scale Precision Oncology Program. PMID:32923873
METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth. PMID:32923617
Small extracellular vesicles modulated by αVβ3 integrin induce neuroendocrine differentiation in recipient cancer cells. PMID:32922691
ATM Mutations Benefit Bladder Cancer Patients Treated With Immune Checkpoint Inhibitors by Acting on the Tumor Immune Microenvironment. PMID:32922441
Identification of angiotensin-converting enzyme 2 (ACE2) protein as the potential biomarker in SARS-CoV-2 infection-related lung cancer using computational analyses. PMID:32916258
Using The Cancer Genome Atlas data to refine the 8th edition of the American Joint Committee on Cancer staging for papillary thyroid carcinoma. PMID:32915437
Mutational Landscape in Resected Periampullary Adenocarcinoma: Relationship With Morphology and Clinical Outcome. PMID:32914025
Genomic Analysis of Metastatic Solid Tumors in Veterans: Findings From the VHA National Precision Oncology Program. PMID:32914016
Genomic Resistance Patterns to Second-Generation Androgen Blockade in Paired Tumor Biopsies of Metastatic Castration-Resistant Prostate Cancer. PMID:32913968
Identification and validation of novel metastasis-related signatures of clear cell renal cell carcinoma using gene expression databases. PMID:32913492
Differences in tumour characteristics of Hepatocellular Carcinoma between patients with and without Cirrhosis: A population-based study. PMID:32913474
Systematic Analysis of the Clinical Relevance of Cell Division Cycle Associated Family in Endometrial Carcinoma. PMID:32913454
GMIEC: a shiny application for the identification of gene-targeted drugs for precision medicine. PMID:32912170
The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs. PMID:32911332
SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells. PMID:32909943
Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns. PMID:32907621
CCAAT/Enhancer-Binding Protein Delta (C/EBPδ): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells. PMID:32906832
Transcriptomic and functional pathway features were associated with survival after pathological complete response to neoadjuvant chemotherapy in breast cancer. PMID:32905537
The m6A readers YTHDF1 and YTHDF3 aberrations associated with metastasis and predict poor prognosis in breast cancer patients. PMID:32905518
Integrative Analysis of the IQ Motif-Containing GTPase-Activating Protein Family Indicates That the IQGAP3-PIK3C2B Axis Promotes Invasion in Colon Cancer. PMID:32903879
Rho GDP-Dissociation Inhibitor 2 Inhibits C-X-C Chemokine Receptor Type 4-Mediated Acute Lymphoblastic Leukemia Cell Migration. PMID:32903764
Artificial Intelligence to Decode Cancer Mechanism: Beyond Patient Stratification for Precision Oncology. PMID:32903628
Prognosis of Lung Adenocarcinoma Patients With NTRK3 Mutations to Immune Checkpoint Inhibitors. PMID:32903385
CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes. PMID:32900797
Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma. PMID:32899449
RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling. PMID:32899426
Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples. PMID:32899175
Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression. PMID:32895052
Identification of a metabolism-related gene expression prognostic model in endometrial carcinoma patients. PMID:32894095
CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade. PMID:32887696
A hypoxia-related signature for clinically predicting diagnosis, prognosis and immune microenvironment of hepatocellular carcinoma patients. PMID:32887635
Prognostic Values for the mRNA Expression of the ADAMTS Family of Genes in Gastric Cancer. PMID:32884571
CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus-Associated Head and Neck Cancers. PMID:32883697
Genomics and Functional Genomics of Malignant Pleural Mesothelioma. PMID:32882916
Cancer-Specific Immune Prognostic Signature in Solid Tumors and Its Relation to Immune Checkpoint Therapies. PMID:32882873
Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development in the Drosophila larval brain. PMID:32878945
Most Commonly Mutated Genes in High-Grade Serous Ovarian Carcinoma Are Nonessential for Ovarian Surface Epithelial Stem Cell Transformation. PMID:32877668
Immortalization of human primary prostate epithelial cells via CRISPR inactivation of the CDKN2A locus and expression of telomerase. PMID:32873916
The HMGB1-2 Ovarian Cancer Interactome. The Role of HMGB Proteins and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and Drug-Response. PMID:32867128
Roles for MDC1 in cancer development and treatment. PMID:32866776
Transcriptional and immunohistological assessment of immune infiltration in pancreatic cancer. PMID:32866185
Aberrant RNA Splicing in Cancer. PMID:32864546
Chromatin remodelling comes into focus. PMID:32864100
m6A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer. PMID:32863943
Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets. PMID:32863893
27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression. PMID:32861706
Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer. PMID:32860789
β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion. PMID:32860047
XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition. PMID:32859985
Impact of genetic alterations on outcomes of patients with stage I nonsmall cell lung cancer: An analysis of the cancer genome atlas data. PMID:32857918
Germline DNMT3A mutation in familial acute myeloid leukaemia. PMID:32856987
DLBCL with amplification of JAK2/PD-L2 exhibits PMBCL-like CNA pattern and worse clinical outcome resembling those with MYD88 L265P mutation. PMID:32854650
Detection of Germline Mutations in a Cohort of 139 Patients with Bilateral Breast Cancer by Multi-Gene Panel Testing: Impact of Pathogenic Variants in Other Genes beyond BRCA1/2. PMID:32854451
Biological Landscape of Triple Negative Breast Cancers Expressing CTLA-4. PMID:32850353
Genetic Alterations and Transcriptional Expression of m6A RNA Methylation Regulators Drive a Malignant Phenotype and Have Clinical Prognostic Impact in Hepatocellular Carcinoma. PMID:32850303
Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers. PMID:32847042
An immune scores-based nomogram for predicting overall survival in patients with clear cell renal cell carcinoma. PMID:32846785
Association of MUC16 Mutation With Response to Immune Checkpoint Inhibitors in Solid Tumors. PMID:32845327
A robust 11-genes prognostic model can predict overall survival in bladder cancer patients based on five cohorts. PMID:32843852
Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma. PMID:32843721
Endometrial Cancer as a Metabolic Disease with Dysregulated PI3K Signaling: Shedding Light on Novel Therapeutic Strategies. PMID:32842547
Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate. PMID:32839463
DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas. PMID:32838940
Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain. PMID:32838755
Protein kinase A inhibitor proteins (PKIs) divert GPCR-Gαs-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth. PMID:32830375
Expression Profile and Prognostic Values of Mini-Chromosome Maintenance Families (MCMs) in Breast Cancer. PMID:32830194
OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity. PMID:32826889
Neoadjuvant metformin added to conventional chemotherapy synergizes anti-proliferative effects in ovarian cancer. PMID:32825834
Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications. PMID:32825279
Role of Adipose Tissue-Derived Autotaxin, Lysophosphatidate Signaling, and Inflammation in the Progression and Treatment of Breast Cancer. PMID:32824846
Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3. PMID:32824461
Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer. PMID:32824360
YB-1 Knockdown Inhibits the Proliferation of Mesothelioma Cells through Multiple Mechanisms. PMID:32823952
Clonal Hematopoiesis in Liquid Biopsy: From Biological Noise to Valuable Clinical Implications. PMID:32823942
Cyclin E2 Promotes Whole Genome Doubling in Breast Cancer. PMID:32823571
Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing. PMID:32822576
Coordinated dysregulation of cancer progression by the HER family and p21-activated kinases. PMID:32820388
Hippo/MST blocks breast cancer by downregulating WBP2 oncogene expression via miRNA processor Dicer. PMID:32820148
Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression. PMID:32820145
Down-regulation of tenascin-C inhibits breast cancer cells development by cell growth, migration, and adhesion impairment. PMID:32817625
A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers. PMID:32817551
SUMOylation of E2F1 Regulates Expression of EZH2. PMID:32816857
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition. PMID:32816843
Deficiency of pseudogene UPAT leads to hepatocellular carcinoma progression and forms a positive feedback loop with ZEB1. PMID:32808348
FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity. PMID:32807875
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints. PMID:32807787
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice. PMID:32807776
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy. PMID:32807225
Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer. PMID:32807223
1-Chromonyl-5-Imidazolylpentadienone Demonstrates Anti-Cancer Action against TNBC and Exhibits Synergism with Paclitaxel. PMID:32806551
Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma. PMID:32801999
Analyses of DNA Methylation Involved in the Activation of Nuclear Karyopherin Alpha 2 Leading to Identify the Progression and Prognostic Significance Across Human Breast Cancer. PMID:32801900
Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. PMID:32796891
Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1. PMID:32796628
Expression of p42.3 in non-small cell lung cancer. PMID:32793664
An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants. PMID:32792368
Subunits of ARID1 serve as novel biomarkers for the sensitivity to immune checkpoint inhibitors and prognosis of advanced non-small cell lung cancer. PMID:32791957
The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma. PMID:32791233
PARP Inhibitors and Prostate Cancer: To Infinity and Beyond BRCA. PMID:32790034
Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide. PMID:32785847
Design and Testing of a Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA. PMID:32785074
Pre-Existing Tumoral B Cell Infiltration and Impaired Genome Maintenance Correlate with Response to Chemoradiotherapy in Locally Advanced Rectal Cancer. PMID:32784964
Notch Transduction in Non-Small Cell Lung Cancer. PMID:32784481
High expression of EMP1 predicts a poor prognosis and correlates with immune infiltrates in bladder urothelial carcinoma. PMID:32782602
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. PMID:32782249
Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer. PMID:32781581
A compendium of mutational cancer driver genes. PMID:32778778
Expanding cancer predisposition genes with ultra-rare cancer-exclusive human variations. PMID:32778766
Current Status of SUMOylation Inhibitors. PMID:32778019
Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer. PMID:32777161
Associations of novel variants in PIK3C3, INSR and MAP3K4 of the ATM pathway genes with pancreatic cancer risk. PMID:32775006
Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast cancer. PMID:32774770
Prognostic value and therapeutic implications of ZHX family member expression in human gastric cancer. PMID:32774706
Somatic mutations in genes associated with mismatch repair predict survival in patients with metastatic cancer receiving immune checkpoint inhibitors. PMID:32774500
Integrated genetic and epigenetic analysis of cancer-related genes in non-ampullary duodenal adenomas and intramucosal adenocarcinomas. PMID:32770675
Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis. PMID:32768595
A phase 2 trial of buparlisib in patients with platinum-resistant metastatic urothelial carcinoma. PMID:32767682
The molecular functions of RIT1 and its contribution to human disease. PMID:32766847
Bioinformatics analysis shows that TOP2A functions as a key candidate gene in the progression of cervical cancer. PMID:32765860
Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer. PMID:32765584
Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence. PMID:32764696
iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome. PMID:32764607
Alternative splicing reverses the cell-intrinsic and cell-extrinsic pro-oncogenic potentials of YAP1. PMID:32763976
High frequency of exon 20 S768I EGFR mutation detected in malignant pleural effusions: A poor prognosticator of NSCLC. PMID:32761886
ROS1-dependent cancers - biology, diagnostics and therapeutics. PMID:32760015
EPHA5 mutation predicts the durable clinical benefit of immune checkpoint inhibitors in patients with lung adenocarcinoma. PMID:32759987
Comprehensive Analysis of Expression, Clinicopathological Association and Potential Prognostic Significance of RABs in Pancreatic Cancer. PMID:32759795
Collagen Type III Alpha 1 chain regulated by GATA-Binding Protein 6 affects Type II IFN response and propanoate metabolism in the recurrence of lower grade glioma. PMID:32757451
Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant. PMID:32756902
The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency. PMID:32755579
Myc linked to dysregulation of cholesterol transport and storage in nonsmall cell lung cancer. PMID:32753459
Unravelling the Role of miR-20b-5p, CCNB1, HMGA2 and E2F7 in Development and Progression of Non-Small Cell Lung Cancer (NSCLC). PMID:32752229
PLEKHS1 Over-Expression is Associated with Metastases and Poor Outcomes in Papillary Thyroid Carcinoma. PMID:32752127
Genomic Database Analysis of Uterine Leiomyosarcoma Mutational Profile. PMID:32751892
Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy. PMID:32751840
Oncogenic Serine 45-Deleted β-Catenin Remains Susceptible to Wnt Stimulation and APC Regulation in Human Colonocytes. PMID:32751567
Metastasis of Uveal Melanoma with Monosomy-3 Is Associated with a Less Glycogenetic Gene Expression Profile and the Dysregulation of Glycogen Storage. PMID:32751097
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer. PMID:32749453
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes. PMID:32747829
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy. PMID:32747819
Prognostic implication and functional annotations of APOBEC3G expression in patients with Melanoma. PMID:32742470
Aberrant methylation and microRNA-target regulation are associated with downregulated NEURL1B: a diagnostic and prognostic target in colon cancer. PMID:32742189
Molecular profiling of immune cell-enriched Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) interacting protein USP13. PMID:32735883
Identification of candidate mediators of chemoresponse in breast cancer through therapy-driven selection of somatic variants. PMID:32734521
Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma. PMID:32733646
X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis. PMID:32732223
Comprehensive Cohort Analysis of Mutational Spectrum in Early Onset Breast Cancer Patients. PMID:32731431
An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. PMID:32729927
Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities. PMID:32727735
PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas. PMID:32727536
Identification of hub genes involved in the occurrence and development of hepatocellular carcinoma via bioinformatics analysis. PMID:32724412
Mining the prognostic significance of the GINS2 gene in human breast cancer using bioinformatics analysis. PMID:32724372
PD-L1 expression increased by IFN-γ via JAK2-STAT1 signaling and predicts a poor survival in colorectal cancer. PMID:32724352
Neratinib in patients with HER2-mutant, metastatic cervical cancer: Findings from the phase 2 SUMMIT basket trial. PMID:32723675
PARP Inhibitor Resistance Mechanisms and Implications for Post-Progression Combination Therapies. PMID:32722408
Pan-Cancer Analysis of the Genomic Alterations and Mutations of the Matrisome. PMID:32722287
Comprehensive Genomic Analysis Reveals the Prognostic Role of LRRK2 Copy-Number Variations in Human Malignancies. PMID:32722212
Transcriptomic Profile of Lymphovascular Invasion, a Known Risk Factor of Pancreatic Ductal Adenocarcinoma Metastasis. PMID:32722116
Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. PMID:32721948
RAS/MAPK Pathway Driver Alterations Are Significantly Associated With Oncogenic KIT Mutations in Germ-cell Tumors. PMID:32721511
Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal adenocarcinoma. PMID:32719550
Comprehensive analysis of the expression and prognosis for CDCAs in head and neck squamous cell carcinoma. PMID:32716971
Construction of a novel prognostic-predicting model correlated to ovarian cancer. PMID:32716025
Cancer-Testis Gene Expression in Hepatocellular Carcinoma: Identification of Prognostic Markers and Potential Targets for Immunotherapy. PMID:32715976
Development and implementation of the SUM breast cancer cell line functional genomics knowledge base. PMID:32715085
Characterisation of Ovarian Cancer Cell Line NIH-OVCAR3 and Implications of Genomic, Transcriptomic, Proteomic and Functional DNA Damage Response Biomarkers for Therapeutic Targeting. PMID:32709004
TCGA Pan-Cancer Genomic Analysis of Alternative Lengthening of Telomeres (ALT) Related Genes. PMID:32708340
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer. PMID:32708015
Chemically Induced Hypoxia Enhances miRNA Functions in Breast Cancer. PMID:32707933
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution. PMID:32707077
FAK inhibition radiosensitizes pancreatic ductal adenocarcinoma cells in vitro. PMID:32705304
Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma. PMID:32704163
Identifying the novel key genes in renal cell carcinoma by bioinformatics analysis and cell experiments. PMID:32699530
Establishment of the prognostic index of lung squamous cell carcinoma based on immunogenomic landscape analysis. PMID:32699529
Establishment of a novel cell cycle-related prognostic signature predicting prognosis in patients with endometrial cancer. PMID:32699528
Integration of Genomic Medicine in Pathology Resident Training. PMID:32696061
Novel Potential Biomarkers Associated With Epithelial to Mesenchymal Transition and Bladder Cancer Prognosis Identified by Integrated Bioinformatic Analysis. PMID:32695668
SFRP1 increases TMPRSS2-ERG expression promoting neoplastic features in prostate cancer in vitro and in vivo. PMID:32694934
Selenium detoxification is required for cancer-cell survival. PMID:32694795
Identifying strategies to target the metabolic flexibility of tumours. PMID:32694609
Bioinformatics analysis of gene expression profile of serous ovarian carcinomas to screen key genes and pathways. PMID:32693821
Increased nuclear factor I/B expression in prostate cancer correlates with AR expression. PMID:32692871
PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells. PMID:32692719
BRD4 regulates key transcription factors that drive epithelial-mesenchymal transition in castration-resistant prostate cancer. PMID:32690869
BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency. PMID:32690724
Clinical significance of EPHX2 deregulation in prostate cancer. PMID:32687069
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. PMID:32686647
Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in Stomach Adenocarcinoma. PMID:32685482
Combined analysis of RNA-sequence and microarray data reveals effective metabolism-based prognostic signature for neuroblastoma. PMID:32683778
Analysis of the "centrosome-ome" identifies MCPH1 deletion as a cause of centrosome amplification in human cancer. PMID:32681070
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer. PMID:32679108
TGFβ2-mediated epithelial-mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance. PMID:32678313
Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer. PMID:32678307
Class IA PI3K regulatory subunits: p110-independent roles and structures. PMID:32677674
Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma. PMID:32676580
Radiomics Features Predict CIC Mutation Status in Lower Grade Glioma. PMID:32676453
Prostate cancer biology & genomics. PMID:32676435
The prognostic value and potential mechanism of Matrix Metalloproteinases among Prostate Cancer. PMID:32669958
Disparate survival of late-stage male oropharyngeal cancer in Appalachia. PMID:32669588
CCR2 of Tumor Microenvironmental Cells Is a Relevant Modulator of Glioma Biology. PMID:32668709
Analysis of the expression and genetic alteration of CLDN18 in gastric cancer. PMID:32668412
Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma. PMID:32667929
The roles of histone variants in fine-tuning chromatin organization and function. PMID:32665685
ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader-Follower Relationship That Drives Collective Invasion. PMID:32661136
High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients. PMID:32658903
Analysis of deubiquitinase OTUD5 as a biomarker and therapeutic target for cervical cancer by bioinformatic analysis. PMID:32655987
ZFHX3 mutation as a protective biomarker for immune checkpoint blockade in non-small cell lung cancer. PMID:32653938
A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma. PMID:32651364
Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency. PMID:32651270
Cell Lineage-Based Stratification for Glioblastoma. PMID:32649888
The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer. PMID:32649682
Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea. PMID:32649211
Novel monoclonal antibody against integrin α3 shows therapeutic potential for ovarian cancer. PMID:32648337
Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells. PMID:32647287
Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution. PMID:32647202
MicroRNAs as Guardians of the Prostate: Those Who Stand before Cancer. What Do We Really Know about the Role of microRNAs in Prostate Biology? PMID:32645914
Association of Independent Prognostic Factors and Treatment Modality With Survival and Recurrence Outcomes in Breast Cancer. PMID:32644137
BRIT1 dysfunction confers synergistic inhibition of hepatocellular carcinoma by targeting poly (ADP-ribose) polymerases and PI3K. PMID:32642299
Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis. PMID:32640634
Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene. PMID:32639993
Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade. PMID:32639068
Characterization of TNNC1 as a Novel Tumor Suppressor of Lung Adenocarcinoma. PMID:32638704
Prognostic Significance of the Pluripotency Factors NANOG, SOX2, and OCT4 in Head and Neck Squamous Cell Carcinomas. PMID:32635524
Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma. PMID:32635224
Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design. PMID:32634377
MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC. PMID:32634121
Bioinformatics analysis of high-throughput data to validate potential novel biomarkers and small molecule drugs for glioblastoma multiforme. PMID:32634050
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling. PMID:32630372
L1CAM, CA9, KLK6, HPN, and ALDH1A1 as Potential Serum Markers in Primary and Metastatic Colorectal Cancer Screening. PMID:32630086
Contribution of Immune Cells to Glucocorticoid Receptor Expression in Breast Cancer. PMID:32629782
Application of cAMP-dependent catalytic subunit β (PRKACB) Low Expression in Predicting Worse Overall Survival: A Potential Therapeutic Target for Colorectal Carcinoma. PMID:32626531
Development and validation of a novel immune-related prognostic model in lung squamous cell carcinoma. PMID:32624696
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target. PMID:32620742
Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions. PMID:32619551
A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue. PMID:32619021
Sustained response to pembrolizumab without prior chemotherapy in high-grade serous ovarian carcinoma with CSMD3 mutation. PMID:32613071
The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer. PMID:32612943
Evaluation of Gene Expression Data From Cybrids and Tumours Highlights Elevated NDRG1-Driven Proliferation in Triple-Negative Breast Cancer. PMID:32612361
miRNA Clusters with Down-Regulated Expression in Human Colorectal Cancer and Their Regulation. PMID:32610706
PTEN Protein Loss and Loss-of-Function Mutations in Gastric Cancers: The Relationship with Microsatellite Instability, EBV, HER2, and PD-L1 Expression. PMID:32610572
KIT and Melanoma: Biological Insights and Clinical Implications. PMID:32608199
ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells. PMID:32606936
Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes. PMID:32605315
Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer. PMID:32603375
Glioma escape signature and clonal development under immune pressure. PMID:32603315
Functional network analysis reveals an immune tolerance mechanism in cancer. PMID:32601217
Tumor Immune Microenvironment Clusters in Localized Prostate Adenocarcinoma: Prognostic Impact of Macrophage Enriched/Plasma Cell Non-Enriched Subtypes. PMID:32599760
Elevated expression of minichromosome maintenance 3 indicates poor outcomes and promotes G1/S cell cycle progression, proliferation, migration and invasion in colorectal cancer. PMID:32597491
miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway. PMID:32596290
Intrinsic and Extrinsic Factors Governing the Transcriptional Regulation of ESR1. PMID:32592004
Systematic Analysis of Spleen Tyrosine Kinase Expression and its Clinical Outcomes in Various Cancers. PMID:32587490
Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer. PMID:32586284
Molecular genetic profiling reveals novel association between FLT3 mutation and survival in glioma. PMID:32583303
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development. PMID:32579928
The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development. PMID:32576626
Phosphodiesterase SMPDL3B Gene Expression as Independent Outcome Prediction Marker in Localized Prostate Cancer. PMID:32575490
Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells. PMID:32571254
ZEB1/miR-200c/AGR2: A New Regulatory Loop Modulating the Epithelial-Mesenchymal Transition in Lung Adenocarcinomas. PMID:32570918
Rare Tumor-Normal Matched Whole Exome Sequencing Identifies Novel Genomic Pathogenic Germline and Somatic Aberrations. PMID:32570879
AML chemoresistance: The role of mutant TP53 subclonal expansion and therapy strategy. PMID:32569759
Prevalence of disease-causing genes in Japanese patients with BRCA1/2-wildtype hereditary breast and ovarian cancer syndrome. PMID:32566746
Bioinformatics analysis of prognosis-related long non-coding RNAs in invasive breast carcinoma. PMID:32565939
FAM83H and SCRIB stabilize β-catenin and stimulate progression of gastric carcinoma. PMID:32564009
Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice. PMID:32561853
The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways. PMID:32561656
Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress. PMID:32559414
CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma. PMID:32555149
Association of molecular characteristics with survival in advanced non-small cell lung cancer patients treated with checkpoint inhibitors. PMID:32554069
MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans. PMID:32553107
Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer. PMID:32552862
Ubiquilin Networking in Cancers. PMID:32549375
Big Data-Based Identification of Multi-Gene Prognostic Signatures in Liver Cancer. PMID:32547951
Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach. PMID:32546937
MicroRNA-17-5p regulates EMT by targeting vimentin in colorectal cancer. PMID:32546833
Cotargeting of XPO1 Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Acute Myeloid Leukemia. PMID:32545904
Neutrophil Extracellular Traps (NETs) Promote Pro-Metastatic Phenotype in Human Breast Cancer Cells through Epithelial-Mesenchymal Transition. PMID:32545405
(-)-Oleocanthal as a Dual c-MET-COX2 Inhibitor for the Control of Lung Cancer. PMID:32545325
Unveiling prognostics biomarkers of tyrosine metabolism reprogramming in liver cancer by cross-platform gene expression analyses. PMID:32542016
Gene expression and prognosis of sirtuin family members in ovarian cancer. PMID:32541517
HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma. PMID:32540961
Molecular Landscape of BRAF-Mutant NSCLC Reveals an Association Between Clonality and Driver Mutations and Identifies Targetable Non-V600 Driver Mutations. PMID:32540409
Identification of methylation-driven genes related to the prognosis of papillary renal cell carcinoma: a study based on The Cancer Genome Atlas. PMID:32536823
Comprehensive analysis of LDHAP5 pseudogene expression and potential pathogenesis in ovarian serous cystadenocarcinoma. PMID:32536817
Why Great Mitotic Inhibitors Make Poor Cancer Drugs. PMID:32536592
Deep learning-based classification and mutation prediction from histopathological images of hepatocellular carcinoma. PMID:32536036
Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma. PMID:32534597
Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator. PMID:32533515
Mediator complex subunit 16 is down-regulated in papillary thyroid cancer, leading to increased transforming growth factor-β signaling and radioiodine resistance. PMID:32532820
Update on GNA Alterations in Cancer: Implications for Uveal Melanoma Treatment. PMID:32532044
Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells. PMID:32528731
miR-410 induces both epithelial-mesenchymal transition and radioresistance through activation of the PI3K/mTOR pathway in non-small cell lung cancer. PMID:32528035
Tissue- and development-stage-specific mRNA and heterogeneous CNV signatures of human ribosomal proteins in normal and cancer samples. PMID:32525984
Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells. PMID:32525891
Myotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma. PMID:32522977
Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer. PMID:32521267
Oncogenic Gene-Expression Programs in Leiomyosarcoma and Characterization of Conventional, Inflammatory, and Uterogenic Subtypes. PMID:32518213
Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein. PMID:32518090
Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression. PMID:32517178
Long Non-Coding RNA HAND2-AS1 Acts as a Tumor Suppressor in High-Grade Serous Ovarian Carcinoma. PMID:32517089
MET-dependent solid tumours - molecular diagnosis and targeted therapy. PMID:32514147
Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells. PMID:32513814
Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma. PMID:32513387
Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes. PMID:32513296
An Overview of Candidate Therapeutic Target Genes in Ovarian Cancer. PMID:32512900
Omics Integration Analyses Reveal the Early Evolution of Malignancy in Breast Cancer. PMID:32512721
G9a Is SETting the Stage for Colorectal Oncogenesis. PMID:32512705
Identifying multiple collagen gene family members as potential gastric cancer biomarkers using integrated bioinformatics analysis. PMID:32509452
Identification of SOCS family members with prognostic values in human ovarian cancer. PMID:32509179
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint. PMID:32508832
Calreticulin couples with immune checkpoints in pancreatic cancer. PMID:32508042
HK3 is correlated with immune infiltrates and predicts response to immunotherapy in non-small cell lung cancer. PMID:32508023
Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination. PMID:32502392
Unleashing the Diagnostic, Prognostic and Therapeutic Potential of the Neuronostatin/GPR107 System in Prostate Cancer. PMID:32498336
WHSC1 monomethylates histone H1 and induces stem-cell like features in squamous cell carcinoma of the head and neck. PMID:32497898
In vivo modeling of metastatic human high-grade serous ovarian cancer in mice. PMID:32497036
Co-Regulation of Immune Checkpoint PD-L1 with Interferon-Gamma Signaling is Associated with a Survival Benefit in Renal Cell Cancer. PMID:32495158
Identification of prognostic gene biomarkers for metastatic skin cancer using data mining. PMID:32494360
RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability. PMID:32494026
GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors. PMID:32493985
FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors. PMID:32493400
FGFR4: A promising therapeutic target for breast cancer and other solid tumors. PMID:32492514
Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in lung cancer. PMID:32492203
Lysophosphatidic acid reverses Temsirolimus-induced changes in lipid droplets and mitochondrial networks in renal cancer cells. PMID:32492043
Study of Caspase 8 mutation in oral cancer and adjacent precancer tissues and implication in progression. PMID:32492030
Radiomics-based nomogram using CT imaging for noninvasive preoperative prediction of early recurrence in patients with hepatocellular carcinoma. PMID:32490826
Guizhi Fuling Decoction inhibiting the PI3K and MAPK pathways in breast cancer cells revealed by HTS2 technology and systems pharmacology. PMID:32489526
Blood-based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Pancreatic Cancer and its Value to Guide Clinical Treatment. PMID:32489450
Nine glycolysis-related gene signature predicting the survival of patients with endometrial adenocarcinoma. PMID:32489319
Fibroblasts as a Biological Marker for Curative Resection in Pancreatic Ductal Adenocarcinoma. PMID:32485981
TRPM4 is overexpressed in breast cancer associated with estrogen response and epithelial-mesenchymal transition gene sets. PMID:32484822
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer. PMID:32483383
Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival. PMID:32481602
A Novel Nomogram Based on Immune Scores for Predicting Survival in Patients with Early-Stage Non-Small Cell Lung Cancer (NSCLC). PMID:32479428
Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models. PMID:32478869
Co-Occurring Alterations of ERBB2 Exon 20 Insertion in Non-Small Cell Lung Cancer (NSCLC) and the Potential Indicator of Response to Afatinib. PMID:32477948
Multifaceted regulation of Notch signaling by glycosylation. PMID:32472127
The Tumor Suppressor TGFBR3 Blocks Lymph Node Metastasis in Head and Neck Cancer. PMID:32471132
Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers. PMID:32467608
Strategies for Functional Interrogation of Big Cancer Data Using Drosophila Cancer Models. PMID:32466549
Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases. PMID:32462403
The SLC Family Are Candidate Diagnostic and Prognostic Biomarkers in Clear Cell Renal Cell Carcinoma. PMID:32461965
Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes. PMID:32461624
Epigenetic downregulation of desmin in gall bladder cancer reveals its potential role in disease progression. PMID:32461394
Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma. PMID:32460791
RAC1 as a Therapeutic Target in Malignant Melanoma. PMID:32460002
Immunoscore Predicts Survival in Early-Stage Lung Adenocarcinoma Patients. PMID:32457841
Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer. PMID:32457491
Molecular patterns in salivary duct carcinoma identify prognostic subgroups. PMID:32457410
An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer. PMID:32455963
Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer. PMID:32455851
ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer. PMID:32454461
An up-to-date overview of computational polypharmacology in modern drug discovery. PMID:32452701
CVCDAP: an integrated platform for molecular and clinical analysis of cancer virtual cohorts. PMID:32449936
Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival. PMID:32445177
Visualizing and interpreting cancer genomics data via the Xena platform. PMID:32444850
Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks. PMID:32444848
SNHG7 is a lncRNA oncogene controlled by Insulin-like Growth Factor signaling through a negative feedback loop to tightly regulate proliferation. PMID:32444795
Loss of Spry1 reduces growth of BRAFV600-mutant cutaneous melanoma and improves response to targeted therapy. PMID:32444628
Screening and identification of key biomarkers for retinoblastoma: Evidence from bioinformatics analysis. PMID:32443297
The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer. PMID:32440535
Targeting eIF3f Suppresses the Growth of Prostate Cancer Cells by Inhibiting Akt Signaling. PMID:32440143
Core Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network. PMID:32439761
First-line pembrolizumab and trastuzumab in HER2-positive oesophageal, gastric, or gastro-oesophageal junction cancer: an open-label, single-arm, phase 2 trial. PMID:32437664
Proliferation-associated long noncoding RNA, TMPO-AS1, is a potential therapeutic target for triple-negative breast cancer. PMID:32437068
Molecular Biological Features of Nottingham Histological Grade 3 Breast Cancers. PMID:32436191
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth. PMID:32433953
Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that PTEN Loss Contributes to Cetuximab Resistance in Head and Neck Cancer. PMID:32430488
Direct comparison shows that mRNA-based diagnostics incorporate information which cannot be learned directly from genomic mutations. PMID:32429832
Epigenetic Alterations in Oesophageal Cancer: Expression and Role of the Involved Enzymes. PMID:32429269
A novel role for NUAK1 in promoting ovarian cancer metastasis through regulation of fibronectin production in spheroids. PMID:32429240
SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation. PMID:32427938
Detecting Cancer Survival Related Gene Markers Based on Rectified Factor Network. PMID:32426342
Identification of potential novel differentially-expressed genes and their role in invasion and migration in renal cell carcinoma. PMID:32420905
Characterization of FANCL variants observed in patient cancer cells. PMID:32420600
Screening and Identification of Differentially Expressed Genes Expressed among Left and Right Colon Adenocarcinoma. PMID:32420374
Long-term survival with targeted therapy in an advanced non-small cell lung cancer patient based on genetic profiling. PMID:32420078
Integrative Analysis of Periostin in Primary and Advanced Prostate Cancer. PMID:32416542
Performance of four platforms for KRAS mutation detection in plasma cell-free DNA: ddPCR, Idylla, COBAS z480 and BEAMing. PMID:32415199
CRISPR screening identifies M1AP as a new MYC regulator with a promoter-reporter system. PMID:32411526
Sulfiredoxin as a Potential Therapeutic Target for Advanced and Metastatic Prostate Cancer. PMID:32411320
Mining the role of angiopoietin-like protein family in gastric cancer and seeking potential therapeutic targets by integrative bioinformatics analysis. PMID:32410376
Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model. PMID:32408898
Identification of transforming growth factor beta induced (TGFBI) as an immune-related prognostic factor in clear cell renal cell carcinoma (ccRCC). PMID:32406866
GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17. PMID:32405532
Frequency and spectrum of PIK3CA somatic mutations in breast cancer. PMID:32404150
HIP1R Expression and Its Association with PD-1 Pathway Blockade Response in Refractory Advanced NonSmall Cell Lung Cancer: A Gene Set Enrichment Analysis. PMID:32403421
Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies. PMID:32403323
In silico analyses identify lncRNAs: WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors. PMID:32401758
CD37 high expression as a potential biomarker and association with poor outcome in acute myeloid leukemia. PMID:32400873
Diagnostic, progressive and prognostic performance of m6A methylation RNA regulators in lung adenocarcinoma. PMID:32398949
Systematic Multiomic Analysis of Ly75 Gene Expression and Its Prognostic Value Through the Infiltration of Natural Killer (NK) Cells in Skin Cutaneous Melanoma. PMID:32397120
Emerging Therapeutic Implications of STK11 Mutation: Case Series. PMID:32396674
Lower Levels of Adiponectin and Its Receptor Adipor1 in the Uveal Melanomas With Monosomy-3. PMID:32396633
CD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancer. PMID:32395395
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. PMID:32393580
Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation. PMID:32393311
E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells. PMID:32391871
The roles of MASPIN expression and subcellular localization in non-small cell lung cancer. PMID:32391558
PBRM1 suppresses tumor growth as a novel p53 acetylation reader. PMID:32391422
Progesterone receptor promotes degradation of STAT2 to inhibit the interferon response in breast cancer. PMID:32391191
Epididymal protein 3A is upregulated and promotes cell proliferation in non-small cell lung cancer. PMID:32391105
Elevated TNFRSF4 gene expression is a predictor of poor prognosis in non-M3 acute myeloid leukemia. PMID:32390761
Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation. PMID:32386122
p85β regulates autophagic degradation of AXL to activate oncogenic signaling. PMID:32385243
Analysis of TP53 aflatoxin signature mutation in hepatocellular carcinomas from Guatemala: A cross-sectional study (2016-2017). PMID:32382660
Expression of yhwaz and gene regulation network in hepatocellular carcinoma. PMID:32382342
Overexpression of LBX2 associated with tumor progression and poor prognosis in colorectal cancer. PMID:32382328
MUC15 inhibits cancer metastasis via PI3K/AKT signaling in renal cell carcinoma. PMID:32382053
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling. PMID:32381551
CCNE1 Amplification as a Predictive Biomarker of Chemotherapy Resistance in Epithelial Ovarian Cancer. PMID:32380689
Identification and validation of the angiogenic genes for constructing diagnostic, prognostic, and recurrence models for hepatocellular carcinoma. PMID:32379058
Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells. PMID:32377817
Androgen attenuates the inactivating phospho-Ser-127 modification of yes-associated protein 1 (YAP1) and promotes YAP1 nuclear abundance and activity. PMID:32376689
The molecular basis of selective DNA binding by the BRG1 AT-hook and bromodomain. PMID:32376391
A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer. PMID:32371585
Establishment and Validation of an Individualized Cell Cycle Process-Related Gene Signature to Predict Cancer-Specific Survival in Patients with Bladder Cancer. PMID:32370292
Molecular Signatures of JMJD10/MINA53 in Gastric Cancer. PMID:32370161
Complement factor H-deficient mice develop spontaneous hepatic tumors. PMID:32369457
The roles and mechanisms of YTH domain-containing proteins in cancer development and progression. PMID:32368386
IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils. PMID:32366475
The Influence of Methylating Mutations on Acute Myeloid Leukemia: Preliminary Analysis on 56 Patients. PMID:32365516
Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases. PMID:32365229
Regulation of eIF2α by RNF4 Promotes Melanoma Tumorigenesis and Therapy Resistance. PMID:32360601
Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth. PMID:32358581
Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer. PMID:32357907
The Clinical Significance of PIWIL3 and PIWIL4 Expression in Pancreatic Cancer. PMID:32357464
Development of a prognostic index of colon adenocarcinoma based on immunogenomic landscape analysis. PMID:32355728
DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres. PMID:32355220
Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity. PMID:32355214
Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish. PMID:32354205
The Role of Crosstalk between AR3 and E2F1 in Drug Resistance in Prostate Cancer Cells. PMID:32354165
Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors. PMID:32352724
Gas6 expression is reduced in advanced breast cancers. PMID:32352034
BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression. PMID:32352029
Comparative proteogenomics profiling of non-small and small lung carcinoma cell lines using mass spectrometry. PMID:32351780
Erlotinib sensitivity of MAPK1p.D321N mutation in head and neck squamous cell carcinoma. PMID:32351709
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation. PMID:32350249
Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma: A Functional Assessment Based on Actin Three-Dimensional Structures. PMID:32349449
The F-box protein FBXL16 up-regulates the stability of C-MYC oncoprotein by antagonizing the activity of the F-box protein FBW7. PMID:32345600
Association Between Spatial Heterogeneity Within Nonmetastatic Gastroesophageal Adenocarcinomas and Survival. PMID:32338752
Identification of a metabolic gene panel to predict the prognosis of myelodysplastic syndrome. PMID:32337851
The Oncogenic Role of CENPA in Hepatocellular Carcinoma Development: Evidence from Bioinformatic Analysis. PMID:32337237
LRG1 May Accelerate the Progression of ccRCC via the TGF-β Pathway. PMID:32337221
Kinome multigenic panel identified novel druggable EPHB4-V871I somatic variant in high-risk neuroblastoma. PMID:32336043
Identification of METTL3 as an Adverse Prognostic Biomarker in Hepatocellular Carcinoma. PMID:32333311
HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity. PMID:32331382
Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors. PMID:32331249
Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy. PMID:32325691
Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis. PMID:32325032
Identification of lung adenocarcinoma biomarkers based on bioinformatic analysis and human samples. PMID:32323809
Targeting Rac and Cdc42 GEFs in Metastatic Cancer. PMID:32322580
High-throughput gene screen reveals modulators of nuclear shape. PMID:32320319
An Effective Graph Clustering Method to Identify Cancer Driver Modules. PMID:32318558
Robust Biomarker Screening Using Spares Learning Approach for Liver Cancer Prognosis. PMID:32318552
Pan-cancer Analysis of CDK12 Alterations Identifies a Subset of Prostate Cancers with Distinct Genomic and Clinical Characteristics. PMID:32317181
Prognostic significance of an invasive leader cell-derived mutation cluster on chromosome 16q. PMID:32315457
Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone. PMID:32314873
ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes. PMID:32313225
Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model. PMID:32313004
TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism. PMID:32312982
A novel 20-gene prognostic score in pancreatic adenocarcinoma. PMID:32310997
Long Non-Coding RNA LEF1-AS1 Promotes Migration, Invasion and Metastasis of Colon Cancer Cells Through miR-30-5p/SOX9 Axis. PMID:32308428
Overexpression of COL24A1 in Hepatocellular Carcinoma Predicts Poor Prognosis: A Study Based on Multiple Databases, Clinical Samples and Cell Lines. PMID:32308416
The SWI/SNF complex in cancer - biology, biomarkers and therapy. PMID:32303701
Plasma membrane expression of G protein-coupled estrogen receptor (GPER)/G protein-coupled receptor 30 (GPR30) is associated with worse outcome in metachronous contralateral breast cancer. PMID:32302351
A Five-Genes-Based Prognostic Signature for Cervical Cancer Overall Survival Prediction. PMID:32300605
CREB1 is affected by the microRNAs miR-22-3p, miR-26a-5p, miR-27a-3p, and miR-221-3p and correlates with adverse clinicopathological features in renal cell carcinoma. PMID:32300145
Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer. PMID:32300050
Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib. PMID:32297440
Comprehensive Analysis of AR Alterations in Circulating Tumor DNA from Patients with Advanced Prostate Cancer. PMID:32297439
Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer. PMID:32295144
Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington's Disease. PMID:32295075
Identification of CELSR2 as a novel prognostic biomarker for hepatocellular carcinoma. PMID:32293343
A negative storage model for precise but compact storage of genetic variation data. PMID:32293013
Mutational landscape and characteristics of ERBB2 in non-small cell lung cancer. PMID:32291971
Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. PMID:32289751
Re-definition of claudin-low as a breast cancer phenotype. PMID:32286297
MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling. PMID:32286266
Lymphovascular invasion in breast cancer is associated with gene expression signatures of cell proliferation but not lymphangiogenesis or immune response. PMID:32285241
The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma. PMID:32284793
Characterization of the prognostic values and response to immunotherapy/chemotherapy of Krüppel-like factors in prostate cancer. PMID:32281273
Transcriptomic Analysis of Glioma Based on IDH Status Identifies ACAA2 as a Prognostic Factor in Lower Grade Glioma. PMID:32280672
Peroxisome proliferator-activated receptor gamma as a theragnostic target for mesenchymal-type glioblastoma patients. PMID:32280134
A novel diagnostic system to evaluate epidermal growth factor receptor impact as a prognostic and therapeutic indicator for lung adenocarcinoma. PMID:32277151
High-Throughput Sequencing Identifies 3 Novel Susceptibility Genes for Hereditary Melanoma. PMID:32276436
The Receptor Tyrosine Kinase RON and Its Isoforms as Therapeutic Targets in Ewing Sarcoma. PMID:32272784
DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation. PMID:32264658
Evaluation of X-Ray Repair Cross-Complementing Family Members as Potential Biomarkers for Predicting Progression and Prognosis in Hepatocellular Carcinoma. PMID:32258128
On the Role of Artificial Intelligence in Genomics to Enhance Precision Medicine. PMID:32256101
STK11 mutation status is associated with decreased survival in meningiomas. PMID:32253637
Genomics of MPNST (GeM) Consortium: Rationale and Study Design for Multi-Omic Characterization of NF1-Associated and Sporadic MPNSTs. PMID:32252413
The pan-cancer landscape of netrin family reveals potential oncogenic biomarkers. PMID:32251318
CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation. PMID:32249801
Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells. PMID:32249776
The Mystery of Rap1 Suppression of Oncogenic Ras. PMID:32249186
Proteomic profiling of FBXW7-mutant serous endometrial cancer cells reveals upregulation of PADI2, a potential therapeutic target. PMID:32248654
Actionable Potentials of Less Frequently Mutated Genes in Colorectal Cancer and Their Roles in Precision Medicine. PMID:32245111
Recognition Dynamics of Cancer Mutations on the ERp57-Tapasin Interface. PMID:32244998
The Missing Lnc: The Potential of Targeting Triple-Negative Breast Cancer and Cancer Stem Cells by Inhibiting Long Non-Coding RNAs. PMID:32244924
SAMHD1 Functions and Human Diseases. PMID:32244340
KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer. PMID:32243837
Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts. PMID:32240795
A genomic and epigenomic atlas of prostate cancer in Asian populations. PMID:32238934
Meta-Analysis Based on Nonconvex Regularization. PMID:32238826
Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis. PMID:32238586
Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy. PMID:32238357
RNF43 mutation is associated with aggressive tumor biology along with BRAF V600E mutation in right-sided colorectal cancer. PMID:32236609
Development of a prognostic index and screening of potential biomarkers based on immunogenomic landscape analysis of colorectal cancer. PMID:32235004
LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma. PMID:32234847
Metastatic Melanoma Patient-Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition. PMID:32234759
Beyond repression of Nrf2: An update on Keap1. PMID:32234331
Controversies around the function of LARP1. PMID:32233986
Histone methyltransferase SETD2: a potential tumor suppressor in solid cancers. PMID:32231741
Landscape of BRIP1 molecular lesions in gastrointestinal cancers from published genomic studies. PMID:32231423
Bioinformatics Analysis of Prognostic Tumor Microenvironment-Related Genes in the Tumor Microenvironment of Hepatocellular Carcinoma. PMID:32231177
Vitamin D Suppresses Ovarian Cancer Growth and Invasion by Targeting Long Non-Coding RNA CCAT2. PMID:32230936
Extracellular Protease ADAMTS1 Is Required at Early Stages of Human Uveal Melanoma Development by Inducing Stemness and Endothelial-Like Features on Tumor Cells. PMID:32230715
A comprehensive analysis of IDO1 expression with tumour-infiltrating immune cells and mutation burden in gynaecologic and breast cancers. PMID:32227579
Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine. PMID:32226924
Upregulation of deubiquitinase PSMD14 in lung adenocarcinoma (LUAD) and its prognostic significance. PMID:32226511
Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation. PMID:32226312
Nucleotide binding domain and leucine-rich repeat pyrin domain-containing protein 12: characterization of its binding to hematopoietic cell kinase. PMID:32226298
Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2. PMID:32224897
Complete response to anti-PD-L1 antibody in a metastatic bladder cancer associated with novel MSH4 mutation and microsatellite instability. PMID:32221012
Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts. PMID:32220884
Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer. PMID:32219437
Transcription levels and prognostic significance of the NFI family members in human cancers. PMID:32219034
Intratumoral heterogeneity of glutaminase and lactate dehydrogenase A protein expression in colorectal cancer. PMID:32218849
VIRMA-Dependent N6-Methyladenosine Modifications Regulate the Expression of Long Non-Coding RNAs CCAT1 and CCAT2 in Prostate Cancer. PMID:32218194
Identification and validation of dichotomous immune subtypes based on intratumoral immune cells infiltration in clear cell renal cell carcinoma patients. PMID:32217761
High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC. PMID:32216563
Identification of prognostic long noncoding RNAs associated with spontaneous regression of neuroblastoma. PMID:32216054
Microbiome analyses of blood and tissues suggest cancer diagnostic approach. PMID:32214244
Coordination of mRNA and tRNA methylations by TRMT10A. PMID:32213595
Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis. PMID:32213586
RNF168-Mediated Ubiquitin Signaling Inhibits the Viability of BRCA1-Null Cancers. PMID:32213544
Cytokines secreted by stromal cells in TNBC microenvironment as potential targets for cancer therapy. PMID:32213106
Cellular processes involved in lung cancer cells exposed to direct current electric field. PMID:32210363
OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine. PMID:32210335
The Frequency of Ras Mutations in Cancer. PMID:32209560
Wild-Type IDH1 and Mutant IDH1 Opposingly Regulate Podoplanin Expression in Glioma. PMID:32208352
Recent Improvements in Genomic and Transcriptomic Understanding of Anaplastic and Poorly Differentiated Thyroid Cancers. PMID:32207263
Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer. PMID:32206093
Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis. PMID:32205868
Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. PMID:32205440
Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells. PMID:32203164
Comprehensive bioinformatic analysis of Wnt1 and Wnt1-associated diseases. PMID:32201670
CD148 Serves as a Prognostic Marker of Gastric Cancer and Hinders Tumor Progression by Dephosphorylating EGFR. PMID:32201537
Integrative Analysis of Siglec-15 mRNA in Human Cancers Based on Data Mining. PMID:32201516
Dissenting degradation: Deubiquitinases in cell cycle and cancer. PMID:32201366
Comparative genomic profiling of glandular bladder tumours. PMID:32198650
Dual regulation of p53 by the ribosome maturation factor SBDS. PMID:32198344
The tubal epigenome - An emerging target for ovarian cancer. PMID:32197795
Cancer Genetics and Therapeutic Opportunities in Urologic Practice. PMID:32197306
Immune and Stroma Related Genes in Breast Cancer: A Comprehensive Analysis of Tumor Microenvironment Based on the Cancer Genome Atlas (TCGA) Database. PMID:32195260
The HIPPO pathway in gynecological malignancies. PMID:32195031
FGD1 promotes tumor progression and regulates tumor immune response in osteosarcoma via inhibiting PTEN activity. PMID:32194840
Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma. PMID:32194798
FKBP4 is a malignant indicator in luminal A subtype of breast cancer. PMID:32194784
ZW10 interacting kinetochore protein may serve as a prognostic biomarker for human breast cancer: An integrated bioinformatics analysis. PMID:32194714
FBW7 in hematological tumors. PMID:32194657
Integrated analysis of gene expression and DNA methylation profiles in ovarian cancer. PMID:32192517
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome. PMID:32188943
Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies. PMID:32188707
Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer. PMID:32188493
Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma. PMID:32188490
Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis. PMID:32187176
Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. PMID:32184446
The Oncogenic Potential of the Centromeric Border Protein FAM84B of the 8q24.21 Gene Desert. PMID:32183428
ATM-Deficient Cancers Provide New Opportunities for Precision Oncology. PMID:32183301
The Role of Polycomb Repressive Complex in Malignant Peripheral Nerve Sheath Tumor. PMID:32182803
Identification of key genes and pathways of diagnosis and prognosis in cervical cancer by bioinformatics analysis. PMID:32181600
Identification of 13 Key Genes Correlated With Progression and Prognosis in Hepatocellular Carcinoma by Weighted Gene Co-expression Network Analysis. PMID:32180800
Gene Expression Alterations and Molecular Analysis of CHEK1 in Solid Tumors. PMID:32178478
Hormone Receptor-Positive/Human Epidermal Growth Receptor 2-Negative Metastatic Breast Cancer in Young Women: Emerging Data in the Era of Molecularly Targeted Agents. PMID:32176406
The construction and analysis of tumor-infiltrating immune cells and ceRNA networks in metastatic adrenal cortical carcinoma. PMID:32175564
Systematical Analysis of the Cancer Genome Atlas Database Reveals EMCN/MUC15 Combination as a Prognostic Signature for Gastric Cancer. PMID:32175327
FBXW4 Is Highly Expressed and Associated With Poor Survival in Acute Myeloid Leukemia. PMID:32175272
Gene mutations distinguishing gastric from colorectal and esophageal adenocarcinomas. PMID:32175104
Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma. PMID:32169869
SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism. PMID:32166001
Tumor mutational burden is associated with poor outcomes in diffuse glioma. PMID:32164609
Identification of potential novel biomarkers to differentiate malignant thyroid nodules with cytological indeterminate. PMID:32164602
Metagenomic characterization of lysine acetyltransferases in human cancer and their association with clinicopathologic features. PMID:32162442
Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors. PMID:32161105
Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma. PMID:32158696
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways. PMID:32156008
Integrated analysis of gene expression, alteration and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer. PMID:32154045
Targeting Chromosomal Architectural HMGB Proteins Could Be the Next Frontier in Cancer Therapy. PMID:32152151
Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer. PMID:32150102
CancerLivER: a database of liver cancer gene expression resources and biomarkers. PMID:32147717
NBIA: a network-based integrative analysis framework - applied to pathway analysis. PMID:32144346
Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain. PMID:32143622
Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer. PMID:32142667
OncoMX: A Knowledgebase for Exploring Cancer Biomarkers in the Context of Related Cancer and Healthy Data. PMID:32142370
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy. PMID:32139506
PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models. PMID:32139402
Non-Thermal Plasma Induces Antileukemic Effect Through mTOR Ubiquitination. PMID:32131492
Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. PMID:32128997
Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer. PMID:32127696
HDMAC: A Web-Based Interactive Program for High-Dimensional Analysis of Molecular Alterations in Cancer. PMID:32127576
Muscleblind-like 2 controls the hypoxia response of cancer cells. PMID:32127384
CDK1 and CDC20 overexpression in patients with colorectal cancer are associated with poor prognosis: evidence from integrated bioinformatics analysis. PMID:32127012
Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis. PMID:32123305
Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells. PMID:32123273
Mutations in the coat complex II component SEC23B promote colorectal cancer metastasis. PMID:32123160
A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets. PMID:32123069
Prioritizing Gene Cascading Paths to Model Colorectal Cancer Through Engineered Organoids. PMID:32117908
Comprehensive Review of Web Servers and Bioinformatics Tools for Cancer Prognosis Analysis. PMID:32117725
Germ Cell-Specific Gene 1-Like Protein Regulated by Splicing Factor CUGBP Elav-Like Family Member 5 and Primary Bile Acid Biosynthesis are Prognostic in Glioblastoma Multiforme. PMID:32117422
Programmed death-ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21-gene and 70-gene signatures in estrogen receptor-positive disease. PMID:32115850
XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary. PMID:32115573
Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells. PMID:32112300
FKBP9 promotes the malignant behavior of glioblastoma cells and confers resistance to endoplasmic reticulum stress inducers. PMID:32111229
Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover. PMID:32106628
Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma. PMID:32104684
Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer. PMID:32103870
Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3. PMID:32102440
Identification of Potential Prognostic Long Non-Coding RNA Biomarkers for Predicting Recurrence in Patients with Cervical Cancer. PMID:32099468
Strategies for Increasing the Effectiveness of Aromatase Inhibitors in Locally Advanced Breast Cancer: An Evidence-Based Review on Current Options. PMID:32099464
Small Molecule Binds with Lymphocyte Antigen 6K to Induce Cancer Cell Death. PMID:32098321
A transcriptional co-expression network-based approach to identify prognostic biomarkers in gastric carcinoma. PMID:32095347
A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma. PMID:32093809
Increased Expression of Micro-RNA-23a Mediates Chemoresistance to Cytarabine in Acute Myeloid Leukemia. PMID:32093419
Identification of Genes Associated with the Metastasis of Pheochromocytoma/Paraganglioma Based on Weighted Gene Coexpression Network Analysis. PMID:32090084
Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers. PMID:32087759
Transcriptome Analysis Identifies ALCAM Overexpression as a Prognosis Biomarker in Laryngeal Squamous Cell Carcinoma. PMID:32085563
Risk score based on expression of five novel genes predicts survival in soft tissue sarcoma. PMID:32084007
Genetic alterations of malignant pleural mesothelioma: association with tumor heterogeneity and overall survival. PMID:32083805
Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma. PMID:32083006
PVT1 Long Non-coding RNA in Gastrointestinal Cancer. PMID:32083000
Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer. PMID:32080887
The clinical and prognostic significance of FOXN3 downregulation in acute myeloid leukaemia. PMID:32078244
Effects of MIR143 on rat sarcoma signaling networks in solid tumors: A brief overview. PMID:32077199
Multi-omics Data Integration, Interpretation, and Its Application. PMID:32076369
Dickkopf-2 (DKK2) as Context Dependent Factor in Patients with Esophageal Adenocarcinoma. PMID:32075129
Epigenetics of SFRP1: The Dual Roles in Human Cancers. PMID:32074995
Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy. PMID:32074012
Fallopian tube initiation of high grade serous ovarian cancer and ovarian metastasis: Mechanisms and therapeutic implications. PMID:32067992
Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis. PMID:32067422
Homologous recombination deficiency status-based classification of high-grade serous ovarian carcinoma. PMID:32066851
DNA repair gene expression is associated with differential prognosis between HPV16 and HPV18 positive cervical cancer patients following radiation therapy. PMID:32066835
Machine Learning and Bioinformatics Models to Identify Pathways that Mediate Influences of Welding Fumes on Cancer Progression. PMID:32066756
A role for caveola-forming proteins caveolin-1 and CAVIN1 in the pro-invasive response of glioblastoma to osmotic and hydrostatic pressure. PMID:32065471
Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery. PMID:32064048
Ubiquitin-specific peptide 22 acts as an oncogene in gastric cancer in a son of sevenless 1-dependent manner. PMID:32063746
Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer. PMID:32061630
Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers. PMID:32059806
The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis. PMID:32057095
Detection of pancreatic ductal adenocarcinoma with galectin-9 serum levels. PMID:32055023
LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance. PMID:32054769
Mechanical regulation of glycolysis via cytoskeleton architecture. PMID:32051585
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically. PMID:32051553
Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal. PMID:32050609
Screening and Identification of Key Biomarkers for Bladder Cancer: A Study Based on TCGA and GEO Data. PMID:32047816
RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice. PMID:32047266
Development and validation of a novel immune-related prognostic model in hepatocellular carcinoma. PMID:32046766
Separated Siamese Twins: Intronic Small Nucleolar RNAs and Matched Host Genes May be Altered in Conjunction or Separately in Multiple Cancer Types. PMID:32046192
Novel ESCC-related gene ZNF750 as potential Prognostic biomarker and inhibits Epithelial-Mesenchymal Transition through directly depressing SNAI1 promoter in ESCC. PMID:32042337
Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts. PMID:32042320
Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling. PMID:32042113
The role of RICTOR amplification in targeted therapy and drug resistance. PMID:32041519
Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night. PMID:32041394
Gene Expression Signature Predictive of Neuroendocrine Transformation in Prostate Adenocarcinoma. PMID:32041153
Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae. PMID:32041123
APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. PMID:32037952
MET targeting: time for a rematch. PMID:32034310
Cyclin-Dependent Kinase and Antioxidant Gene Expression in Cancers with Poor Therapeutic Response. PMID:32033319
Synergy between Non-Thermal Plasma with Radiation Therapy and Olaparib in a Panel of Breast Cancer Cell Lines. PMID:32033118
Identifying multi-hit carcinogenic gene combinations: Scaling up a weighted set cover algorithm using compressed binary matrix representation on a GPU. PMID:32029803
Individual-patient prediction of meningioma malignancy and survival using the Surveillance, Epidemiology, and End Results database. PMID:32025573
Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model. PMID:32025000
Biologically Aggressive Phenotype and Anti-cancer Immunity Counterbalance in Breast Cancer with High Mutation Rate. PMID:32024876
Molecular profiling identifies synchronous endometrial and ovarian cancers as metastatic endometrial cancer with favorable clinical outcome. PMID:32022266
Oncogene-dependent function of BRG1 in hepatocarcinogenesis. PMID:32019910
Probing the mutational landscape of regulators of G protein signaling proteins in cancer. PMID:32019900
Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches. PMID:32019869
Integrative analysis of highly mutated genes in hepatitis B virus-related hepatic carcinoma. PMID:32017470
Identification of cancer driver genes based on nucleotide context. PMID:32015527
Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer. PMID:32015486
Synthetic Lethal Targeting of Mitotic Checkpoints in HPV-Negative Head and Neck Cancer. PMID:32012873
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer. PMID:32012149
Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics. PMID:32010623
Genomic Features and Clinical Characteristics of Adolescents and Young Adults With Cholangiocarcinoma. PMID:32010606
Cyclin D1 expression as a potential prognostic factor in advanced KRAS-mutant non-small cell lung cancer. PMID:32010574
Comparative expression analysis in small cell lung carcinoma reveals neuroendocrine pattern change in primary tumor versus lymph node metastases. PMID:32010572
Grainyhead-like transcription factors in cancer - Focus on recent developments. PMID:32008358
Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone. PMID:32007910
Comprehensive analysis of inhibitor of differentiation/DNA-binding gene family in lung cancer using bioinformatics methods. PMID:32003423
Clinical characteristics of malignant melanoma in central China and predictors of metastasis. PMID:32002034
Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients. PMID:32000721
Bioinformatics-Based Discovery of CKLF-Like MARVEL Transmembrane Member 5 as a Novel Biomarker for Breast Cancer. PMID:31998718
Phase II Trial of Cabozantinib in Recurrent/Metastatic Endometrial Cancer: A Study of the Princess Margaret, Chicago, and California Consortia (NCI9322/PHL86). PMID:31992589
Evidence-Based Network Approach to Recommending Targeted Cancer Therapies. PMID:31990579
Carcinogenesis effects of E2F transcription factor 8 (E2F8) in hepatocellular carcinoma outcomes: an integrated bioinformatic report. PMID:31990034
PIK3CA gene aberrancy and role in targeted therapy of solid malignancies. PMID:31988478
Low-frequency TP53 hotspot mutation contributes to chemoresistance through clonal expansion in acute myeloid leukemia. PMID:31988438
Machine Learning and Network Analyses Reveal Disease Subtypes of Pancreatic Cancer and their Molecular Characteristics. PMID:31988390
Lipid desaturation-associated endoplasmic reticulum stress regulates MYCN gene expression in hepatocellular carcinoma cells. PMID:31988297
Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28. PMID:31982308
Mesothelioma: Hippo pathway as a target, lessons from COMMAND. PMID:31976036
Replisome genes regulation by antitumor miR-101-5p in clear cell renal cell carcinoma. PMID:31975570
Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing. PMID:31974171
A Multi-Omics Analysis of Bone Morphogenetic Protein 5 (BMP5) mRNA Expression and Clinical Prognostic Outcomes in Different Cancers Using Bioinformatics Approaches. PMID:31973134
Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia. PMID:31971569
Genetic alterations of interleukin-17 and related genes in human prostate cancer. PMID:31970232
IDH1-R132H mutation radiosensitizes U87MG glioma cells via epigenetic downregulation of TIGAR. PMID:31966064
Downregulation of LINC01140 is associated with adverse features of breast cancer. PMID:31966045
Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis. PMID:31964905
A qualitative transcriptional signature for predicting the biochemical recurrence risk of prostate cancer patients after radical prostatectomy. PMID:31961962
HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair. PMID:31960047
Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers. PMID:31959902
Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity. PMID:31959836
Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression. PMID:31957540
Germline mutations of SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type and in SMARCA4-deficient undifferentiated uterine sarcoma: Clinical features of a single family and comparison of large cohorts. PMID:31954538
Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes. PMID:31953484
Single-molecule detection of cancer mutations using a novel PCR-LDR-qPCR assay. PMID:31950578
Clinical relevance of somatic mutations in main driver genes detected in gastric cancer patients by next-generation DNA sequencing. PMID:31949278
Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis. PMID:31949145
Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment. PMID:31944090
Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer. PMID:31942683
MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer. PMID:31942031
FOXD3 Regulates VISTA Expression in Melanoma. PMID:31940493
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses. PMID:31940491
Clinical implication of UCA1 in non-small cell lung cancer and its effect on caspase-3/7 activation and apoptosis induction in vitro. PMID:31938341
Cell adhesion in cancer: Beyond the migration of single cells. PMID:31937589
Sorafenib Inhibits Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in Hepatocellular Carcinoma Cells. PMID:31936661
Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis. PMID:31935372
Prognostic value of epithelial-mesenchymal transition related genes: SLUG and QKI in breast cancer patients. PMID:31934023
The clinical significance of CHEK1 in breast cancer: a high-throughput data analysis and immunohistochemical study. PMID:31933717
C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts. PMID:31931851
Trametinib Activity in Patients with Solid Tumors and Lymphomas Harboring BRAF Non-V600 Mutations or Fusions: Results from NCI-MATCH (EAY131). PMID:31924734
Emerging Functions of Human IFIT Proteins in Cancer. PMID:31921891
Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4. PMID:31921386
TRIP13 regulates DNA repair pathway choice through REV7 conformational change. PMID:31915374
Generating Stable Knockout Zebrafish Lines by Deleting Large Chromosomal Fragments Using Multiple gRNAs. PMID:31915253
Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance. PMID:31914141
Integrative network analysis identifies cell-specific trans regulators of m6A. PMID:31912146
The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors. PMID:31911857
Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR-Mutant Lung Cancer. PMID:31911548
Omics-based integrated analysis identified ATRX as a biomarker associated with glioma diagnosis and prognosis. PMID:31908895
Amyloid Beta (A4) Precursor Protein: A Potential Biomarker for Recurrent Nasopharyngeal Carcinoma. PMID:31908537
Genetic analysis of pleomorphic and florid lobular carcinoma in situ variants: frequent ERBB2/ERBB3 alterations and clonal relationship to classic lobular carcinoma in situ and invasive lobular carcinoma. PMID:31907376
High MYC mRNA Expression Is More Clinically Relevant than MYC DNA Amplification in Triple-Negative Breast Cancer. PMID:31905596
SIRPB1 promotes prostate cancer cell proliferation via Akt activation. PMID:31905248
The prognostic value of tumor mutation burden in EGFR-mutant advanced lung adenocarcinoma, an analysis based on cBioPortal data base. PMID:31903239
Multi-cancer V-ATPase molecular signatures: A distinctive balance of subunit C isoforms in esophageal carcinoma. PMID:31901859
Aberrant Epidermal Growth Factor Receptor RNA Splice Products Are Among the Most Frequent Somatic Alterations in Clear Cell Renal Cell Carcinoma and Are Associated with a Poor Response to Immunotherapy. PMID:31901438
Retained or altered expression of major histocompatibility complex class I in patient-derived xenograft models in breast cancer. PMID:31900802
Spitz melanoma is a distinct subset of spitzoid melanoma. PMID:31900433
A regulatory role for CHD2 in myelopoiesis. PMID:31900031
TRPV6 as A Target for Cancer Therapy. PMID:31897233
Bioinformatics analysis of the expression of HOXC13 and its role in the prognosis of breast cancer. PMID:31897205
POLR1B is upregulated and promotes cell proliferation in non-small cell lung cancer. PMID:31897183
Genome-wide analysis reveals the emerging roles of long non-coding RNAs in cancer. PMID:31897174
FNDC3B is associated with ER stress and poor prognosis in cervical cancer. PMID:31897153
BATF acts as an oncogene in non-small cell lung cancer. PMID:31897131
ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity. PMID:31895940
Short-Term Environmental Conditioning Enhances Tumorigenic Potential of Triple-Negative Breast Cancer Cells. PMID:31893233
High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation. PMID:31892360
Comprehensive analysis of DNA methylation and gene expression profiles in cholangiocarcinoma. PMID:31889904
Structure and regulation of human epithelial cell transforming 2 protein. PMID:31888991
Discovering Rare Genes Contributing to Cancer Stemness and Invasive Potential by GBM Single-Cell Transcriptional Analysis. PMID:31888172
Insulin-Like Growth Factor Binding Protein 5-A Probable Target of Kidney Renal Papillary Renal Cell Carcinoma. PMID:31886201
The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer. PMID:31880305
Genetic links between endometriosis and cancers in women. PMID:31879572
Single Nucleotide Polymorphism rs6942067 Is a Risk Factor in Young and in Non-Smoking Patients with HPV Negative Head and Neck Squamous Cell Carcinoma. PMID:31878157
Genomics of lethal prostate cancer at diagnosis and castration resistance. PMID:31874108
Fluorouracil sensitivity in a head and neck squamous cell carcinoma with a somatic DPYD structural variant. PMID:31871216
Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity. PMID:31869219
SMAD4 Somatic Mutations in Head and Neck Carcinoma Are Associated With Tumor Progression. PMID:31867281
The Thyroid Hormone Receptor-RUNX2 Axis: A Novel Tumor Suppressive Pathway in Breast Cancer. PMID:31865591
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth. PMID:31863007
Reactive Oxygen Species Drive Proliferation in Acute Myeloid Leukemia via the Glycolytic Regulator PFKFB3. PMID:31862780
Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma. PMID:31862696
Modulation of proliferation factors in lung adenocarcinoma with an analysis of the transcriptional consequences of genomic EGFR activation. PMID:31857847
Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer. PMID:31852841
Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma. PMID:31852831
Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition. PMID:31852795
Screening, identification and validation of CCND1 and PECAM1/CD31 for predicting prognosis in renal cell carcinoma patients. PMID:31850854
Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer. PMID:31849319
RHPCG: a database of the Regulation of the Hippo Pathway in Cancer Genome. PMID:31848596
ERK1 indicates good prognosis and inhibits breast cancer progression by suppressing YAP1 signaling. PMID:31848326
FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1. PMID:31846430
Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer. PMID:31844668
Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer. PMID:31842906
Preoperative plasma fatty acid metabolites inform risk of prostate cancer progression and may be used for personalized patient stratification. PMID:31842810
A systematic analysis of immune genes and overall survival in cancer patients. PMID:31842801
Temporal VEGFA responsive genes in HUVECs: Gene signatures and potential ligands/receptors fine-tuning angiogenesis. PMID:31840205
Systematic expression analysis of WEE family kinases reveals the importance of PKMYT1 in breast carcinogenesis. PMID:31837068
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas. PMID:31836708
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy. PMID:31836706
Prostate-Derived ETS Factor (PDEF) Modulates Yes Associated Protein 1 (YAP1) in Prostate Cancer Cells: A Potential Cross-Talk between PDEF and Hippo Signaling. PMID:31835563
Harmonization of Tumor Mutational Burden Quantification and Association With Response to Immune Checkpoint Blockade in Non-Small-Cell Lung Cancer. PMID:31832578
Dickkopf-related protein 1, a new biomarker for local immune status and poor prognosis among patients with colorectal liver Oligometastases: a retrospective study. PMID:31830954
Long Noncoding RNA PTTG3P Expression Is an Unfavorable Prognostic Marker for Patients With Hepatocellular Carcinoma. PMID:31829099
Integrative Analysis Reveals Comprehensive Altered Metabolic Genes Linking with Tumor Epigenetics Modification in Pan-Cancer. PMID:31828117
Clinical significance of stromal ER and PR expression in periampullary adenocarcinoma. PMID:31827798
NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis. PMID:31827722
MAP2K1 is a potential therapeutic target in erlotinib resistant head and neck squamous cell carcinoma. PMID:31827134
Alterations of the interactome of Bcl-2 proteins in breast cancer at the transcriptional, mutational and structural level. PMID:31825969
A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. PMID:31825826
NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma. PMID:31824170
Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer. PMID:31822799
Transient receptor potential cation channel subfamily V and breast cancer. PMID:31822791
PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization. PMID:31822657
Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer. PMID:31822495
Prognostic value of immune-related genes in clear cell renal cell carcinoma. PMID:31821170
High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer. PMID:31819188
Increased inflammatory lipid metabolism and anaplerotic mitochondrial activation follow acquired resistance to vemurafenib in BRAF-mutant melanoma cells. PMID:31819183
Aberrant activation of hepatocyte growth factor/MET signaling promotes β-catenin-mediated prostatic tumorigenesis. PMID:31819003
RASSF10 Is a TGFβ-Target That Regulates ASPP2 and E-Cadherin Expression and Acts as Tumor Suppressor That Is Epigenetically Downregulated in Advanced Cancer. PMID:31817988
Newly Developed CK1-Specific Inhibitors Show Specifically Stronger Effects on CK1 Mutants and Colon Cancer Cell Lines. PMID:31817920
Pannexin1 Is Associated with Enhanced Epithelial-To-Mesenchymal Transition in Human Patient Breast Cancer Tissues and in Breast Cancer Cell Lines. PMID:31817827
TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-κB Signaling Cascade. PMID:31817720
Collagen prolyl 4-hydroxylase 2 predicts worse prognosis and promotes glycolysis in cervical cancer. PMID:31814898
Identification of potential core genes in metastatic renal cell carcinoma using bioinformatics analysis. PMID:31814889
Development and preclinical pharmacology of a novel dCK inhibitor, DI-87. PMID:31812677
The most common RNF43 mutant G659Vfs*41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis. PMID:31811196
Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress. PMID:31809739
Bioinformatics Analysis of Expression and Alterations of BARD1 in Breast Cancer. PMID:31808361
Reduced expression of microRNA-139-5p in hepatocellular carcinoma results in a poor outcome: An exploration the roles of microRNA-139-5p in tumorigenesis, advancement and prognosis at the molecular biological level using an integrated meta-analysis and bioinformatic investigation. PMID:31807180
Identification of key candidate genes and pathways in endometrial cancer: Evidence from bioinformatics analysis. PMID:31807178
Expression levels and prognostic values of annexins in liver cancer. PMID:31807177
Spatial EGFR Dynamics and Metastatic Phenotypes Modulated by Upregulated EphB2 and Src Pathways in Advanced Prostate Cancer. PMID:31805710
The Impact of High-mobility Group Box Mutation of T-cell Factor 4 on Its Genomic Binding Pattern in Non-small Cell Lung Cancer. PMID:31805518
Genetic And Epigenetic Regulation Of E-Cadherin Signaling In Human Hepatocellular Carcinoma. PMID:31802937
Cardioinformatics: the nexus of bioinformatics and precision cardiology. PMID:31802103
Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function. PMID:31801617
The activating transcription factor 2: an influencer of cancer progression. PMID:31799611
Casein Kinase 1 Delta Regulates Cell Proliferation, Response to Chemotherapy and Migration in Human Ovarian Cancer Cells. PMID:31799185
Functional network analysis of gene-phenotype connectivity based on pioglitazone. PMID:31798704
Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression. PMID:31796516
Analysis of the Whole-Exome Sequencing of Tumor and Circulating Tumor DNA in Metastatic Melanoma. PMID:31795494
Integrative In Silico and In Vitro Transcriptomics Analysis Revealed Gene Expression Changes and Oncogenic Features of Normal Cholangiocytes after Chronic Alcohol Exposure. PMID:31795085
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. PMID:31792461
Identification of key pathways and genes in PTEN mutation prostate cancer by bioinformatics analysis. PMID:31791268
P63 modulates the expression of the WDFY2 gene which is implicated in cancer regulation and limb development. PMID:31789342
Identification of key candidate genes for colorectal cancer by bioinformatics analysis. PMID:31788116
Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer. PMID:31788076
Five extracellular matrix-associated genes upregulated in oral tongue squamous cell carcinoma: An integrated bioinformatics analysis. PMID:31788070
Identification of key genes and evaluation of clinical outcomes in lung squamous cell carcinoma using integrated bioinformatics analysis. PMID:31788059
GABRQ expression is a potential prognostic marker for patients with clear cell renal cell carcinoma. PMID:31788046
Proactive visual and statistical analysis of genomic data in Epiviz. PMID:31782758
VISTA expression is associated with a favorable prognosis in patients with high-grade serous ovarian cancer. PMID:31781843
A stroma-corrected ZEB1 transcriptional signature is inversely associated with antitumor immune activity in breast cancer. PMID:31780722
Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma. PMID:31780666
Combined genetic mutations and DNA-methylated genes as biomarkers for endometrial cancer detection from cervical scrapings. PMID:31779688
β-HPV 8E6 Attenuates ATM and ATR Signaling in Response to UV Damage. PMID:31779191
Bioinformatics analysis reveals 6 key biomarkers associated with non-small-cell lung cancer. PMID:31775549
Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis. PMID:31775037
A comparative study of multi-omics integration tools for cancer driver gene identification and tumour subtyping. PMID:31774481
Peroxisome proliferator-activated receptor gamma controls prostate cancer cell growth through AR-dependent and independent mechanisms. PMID:31769890
The Emerging Roles of ATP-Dependent Chromatin Remodeling Complexes in Pancreatic Cancer. PMID:31769422
Tasks, Techniques, and Tools for Genomic Data Visualization. PMID:31768085
Cellular Processes Involved in Jurkat Cells Exposed to Nanosecond Pulsed Electric Field. PMID:31766457
Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing. PMID:31765373
Bioinformatics analyses of publicly available NEPCa datasets. PMID:31763364
Expression of EMT-Related Genes CAMK2N1 and WNT5A is increased in Locally Invasive and Metastatic Prostate Cancer. PMID:31762801
Aberrant expression of embryonic mesendoderm factor MESP1 promotes tumorigenesis. PMID:31761621
FGF Signalling in the Self-Renewal of Colon Cancer Organoids. PMID:31758153
Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases. PMID:31754720
Metabolic gene alterations impact the clinical aggressiveness and drug responses of 32 human cancers. PMID:31754644
Clinical Spectrum and Functional Consequences Associated with Bi-Allelic Pathogenic PNPT1 Variants. PMID:31752325
Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma. PMID:31751860
SMARCA4-Deficient Thoracic Sarcomatoid Tumors Represent Primarily Smoking-Related Undifferentiated Carcinomas Rather Than Primary Thoracic Sarcomas. PMID:31751681
Study of the antitumour effects and the modulation of immune response by histamine in breast cancer. PMID:31748740
Functional characterization of MCAK/Kif2C cancer mutations using high-throughput microscopic analysis. PMID:31746663
Identification of potential hub genes related to the progression and prognosis of hepatocellular carcinoma through integrated bioinformatics analysis. PMID:31746405
Screening and identification of key biomarkers in prostate cancer using bioinformatics. PMID:31746380
Response to Immunotherapy in Combination With Mitotane in Patients With Metastatic Adrenocortical Cancer. PMID:31745526
Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma. PMID:31744494
Defining Signatures of Arm-Wise Copy Number Change and Their Associated Drivers in Kidney Cancers. PMID:31744086
Systems analysis of barrier molecule and ARNT-related gene expression regulation in melanoma. PMID:31741768
Tumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer. PMID:31741762
High Tumor Mutation Burden and Other Immunotherapy Response Predictors in Breast Cancers: Associations and Therapeutic Opportunities. PMID:31741177
BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration. PMID:31740786
Systematic mutation analysis in rare colorectal cancer presenting ovarian metastases. PMID:31740709
The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma. PMID:31739284
High expression of polo-like kinase 1 is associated with TP53 inactivation, DNA repair deficiency, and worse prognosis in ER positive Her2 negative breast cancer. PMID:31737202
Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity. PMID:31733993
RNA-binding protein NONO promotes breast cancer proliferation by post-transcriptional regulation of SKP2 and E2F8. PMID:31733123
Interleukin-18 Is a Prognostic Biomarker Correlated with CD8+ T Cell and Natural Killer Cell Infiltration in Skin Cutaneous Melanoma. PMID:31731729
Mutation-Driven Signals of ARID1A and PI3K Pathways in Ovarian Carcinomas: Alteration Is An Opportunity. PMID:31731647
Late recurrence of breast cancer is associated with pro-cancerous immune microenvironment in the primary tumor. PMID:31729458
EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma. PMID:31727135
Significant association between high serum CCL5 levels and better disease-free survival of patients with early breast cancer. PMID:31724785
p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma. PMID:31720078
Cytokeratin 7-negative and GATA binding protein 3-negative breast cancers: Clinicopathological features and prognostic significance. PMID:31718619
Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1. PMID:31718065
Expression of Adenosine Receptors in Rodent Pancreas. PMID:31717704
APOBEC3-Mediated RNA Editing in Breast Cancer is Associated with Heightened Immune Activity and Improved Survival. PMID:31717692
Lipid Related Genes Altered in NASH Connect Inflammation in Liver Pathogenesis Progression to HCC: A Canonical Pathway. PMID:31717414
KRAS regulation by small non-coding RNAs and SNARE proteins. PMID:31712554
mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma. PMID:31712311
Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells. PMID:31711466
KRAS/NRAS/BRAF Mutations as Potential Targets in Multiple Myeloma. PMID:31709194
Pan-Cancer Analysis of Potential Synthetic Lethal Drug Targets Specific to Alterations in DNA Damage Response. PMID:31709193
OCTANE (Ontario-wide Cancer Targeted Nucleic Acid Evaluation): a platform for intraprovincial, national, and international clinical data-sharing. PMID:31708655
The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities. PMID:31703360
DriverDBv3: a multi-omics database for cancer driver gene research. PMID:31701128
Prognostic role of the beta-2 adrenergic receptor in clear cell renal cell carcinoma. PMID:31700702
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors. PMID:31699932
Copy number of 8q24.3 drives HSF1 expression and patient outcome in cancer: an individual patient data meta-analysis. PMID:31699156
Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo. PMID:31697837
Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade. PMID:31697821
Comprehensive characterization of the alternative splicing landscape in head and neck squamous cell carcinoma reveals novel events associated with tumorigenesis and the immune microenvironment. PMID:31695792
A Multi-Element Expression Score Is A Prognostic Factor In Glioblastoma Multiforme. PMID:31695490
Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer. PMID:31695102
GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients. PMID:31694641
Hepatitis C Virus Enhances the Invasiveness of Hepatocellular Carcinoma via EGFR-Mediated Invadopodia Formation and Activation. PMID:31694343
Characterization of HMGB1/2 Interactome in Prostate Cancer by Yeast Two Hybrid Approach: Potential Pathobiological Implications. PMID:31694235
TYK2: An Upstream Kinase of STATs in Cancer. PMID:31694222
Prolyl hydroxylase-3 is a novel renal cell carcinoma biomarker. PMID:31692952
CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth. PMID:31685994
The paracrine induction of prostate cancer progression by caveolin-1. PMID:31685812
Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability. PMID:31685811
ER-Negative Breast Cancer Is Highly Responsive to Cholesterol Metabolite Signalling. PMID:31683867
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Mesothelioma With Bone Metastasis. PMID:31681739
Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers. PMID:31681587
RAS: Striking at the Core of the Oncogenic Circuitry. PMID:31681559
Burden of rare exome sequence variants in PROC gene is associated with venous thromboembolism: a population-based study. PMID:31680443
Prognostic significance of KN motif and ankyrin repeat domains 1 (KANK1) in invasive breast cancer. PMID:31679074
High-resolution copy number analysis of clear cell endometrial carcinoma. PMID:31678638
Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer. PMID:31678591
HMGB1: an overview of its versatile roles in the pathogenesis of colorectal cancer. PMID:31677065
DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma. PMID:31676785
Synergistic apoptosis of human gastric cancer cells by bortezomib and TRAIL. PMID:31673231
Targeting Novel Sodium Iodide Symporter Interactors ADP-Ribosylation Factor 4 and Valosin-Containing Protein Enhances Radioiodine Uptake. PMID:31672844
SL-BioDP: Multi-Cancer Interactive Tool for Prediction of Synthetic Lethality and Response to Cancer Treatment. PMID:31671773
Context-dependent roles of complement in cancer. PMID:31666715
Functional analysis of RPS27 mutations and expression in melanoma. PMID:31663663
Genome-Wide Small RNA Sequencing Identifies MicroRNAs Deregulated in Non-Small Cell Lung Carcinoma Harboring Gain-of-Function Mutant p53. PMID:31661871
CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50. PMID:31660072
Landscape of Germline Mutations in DNA Repair Genes for Breast Cancer in Latin America: Opportunities for PARP-Like Inhibitors and Immunotherapy. PMID:31658756
Increased expression of TET3 predicts unfavorable prognosis in patients with ovarian cancer-a bioinformatics integrative analysis. PMID:31656201
Overexpression of steroid sulfotransferase genes is associated with worsened prognosis and with immune exclusion in clear cell-renal cell carcinoma. PMID:31655797
Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients. PMID:31653970
Modulating cellular cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing. PMID:31653966
PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9. PMID:31652979
High Expression of TTYH3 is Related to Poor Clinical Outcomes in Human Gastric Cancer. PMID:31652813
ACTL6A regulates follicle-stimulating hormone-driven glycolysis in ovarian cancer cells via PGK1. PMID:31649264
Pathway Commons 2019 Update: integration, analysis and exploration of pathway data. PMID:31647099
Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation. PMID:31647098
Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors. PMID:31646100
Docking protein-1 promotes inflammatory macrophage signaling in gastric cancer. PMID:31646096
Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer. PMID:31645543
Integrative analysis of genetic and epigenetic profiling of lung squamous cell carcinoma (LSCC) patients to identify smoking level relevant biomarkers. PMID:31641374
Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion. PMID:31641031
Exploiting ING2 Epigenetic Modulation as a Therapeutic Opportunity for Non-Small Cell Lung Cancer. PMID:31640185
SOX2 Expression Is an Independent Predictor of Oral Cancer Progression. PMID:31640140
PIAS1 is not suitable as a urothelial carcinoma biomarker protein and pharmacological target. PMID:31639157
β‑elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A‑VEGFA pathway based on network pharmacology. PMID:31638231
Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers. PMID:31637211
Identification of key genes and multiple molecular pathways of metastatic process in prostate cancer. PMID:31637138
ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy. PMID:31636955
PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells. PMID:31636389
HNF1B-mediated repression of SLUG is suppressed by EZH2 in aggressive prostate cancer. PMID:31636385
Mutational inactivation of mTORC1 repressor gene DEPDC5 in human gastrointestinal stromal tumors. PMID:31636198
ICOSLG-mediated regulatory T-cell expansion and IL-10 production promote progression of glioblastoma. PMID:31634400
Why Be One Protein When You Can Affect Many? The Multiple Roles of YB-1 in Lung Cancer and Mesothelioma. PMID:31632972
Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors. PMID:31632920
INPP4B As A Prognostic And Diagnostic Marker Regulates Cell Growth Of Pancreatic Cancer Via Activating AKT. PMID:31632078
Antisense targeting of CD47 enhances human cytotoxic T-cell activity and increases survival of mice bearing B16 melanoma when combined with anti-CTLA4 and tumor irradiation. PMID:31628526
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia. PMID:31628323
CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation. PMID:31627350
Programmed Death Ligand 1 Indicates Pre-Existing Adaptive Immune Response by Tumor-Infiltrating CD8+ T Cells in Non-Small Cell Lung Cancer. PMID:31627272
Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers. PMID:31623662
Identification of prognostic biomarkers for malignant melanoma using microarray datasets. PMID:31620197
Open-Sourced CIViC Annotation Pipeline to Identify and Annotate Clinically Relevant Variants Using Single-Molecule Molecular Inversion Probes. PMID:31618044
Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis. PMID:31616062
HOIL-1, an atypical E3 ligase that controls MyD88 signalling by forming ester bonds between ubiquitin and components of the Myddosome. PMID:31615747
Detailed Characterization of Immune Cell Infiltrate and Expression of Immune Checkpoint Molecules PD-L1/CTLA-4 and MMR Proteins in Testicular Germ Cell Tumors Disclose Novel Disease Biomarkers. PMID:31614500
Fast fluorescence in situ hybridisation for the enhanced detection of MET in non-small cell lung cancer. PMID:31613934
The Effects of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer-The Impact in Intratumoral Heterogeneity. PMID:31612112
Diagnostic and prognostic value of the BEX family in lung adenocarcinoma. PMID:31612060
Identification of candidate genes for the diagnosis and treatment of cholangiocarcinoma using a bioinformatics approach. PMID:31612054
Screening and identification of key biomarkers in lung squamous cell carcinoma by bioinformatics analysis. PMID:31612029
Evaluation of the target genes of arsenic trioxide in pancreatic cancer by bioinformatics analysis. PMID:31612027
Long non-coding RNA small nucleolar RNA host gene 7 is upregulated and promotes cell proliferation in thyroid cancer. PMID:31611982
Screening and authentication of molecular markers in malignant glioblastoma based on gene expression profiles. PMID:31611967
Identification of key biomarkers and potential molecular mechanisms in lung cancer by bioinformatics analysis. PMID:31611952
KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. PMID:31611389
Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells. PMID:31610800
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. PMID:31607565
Advancing Pan-cancer Gene Expression Survial Analysis by Inclusion of Non-coding RNA. PMID:31607216
The combination of BET and PARP inhibitors is synergistic in models of cholangiocarcinoma. PMID:31605774
ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer. PMID:31604914
The Pan-Cancer Landscape of Coamplification of the Tyrosine Kinases KIT, KDR, and PDGFRA. PMID:31604903
Detection of Novel Fusion Transcript VTI1A-CFAP46 in Hepatocellular Carcinoma. PMID:31602373
A cellular and bioinformatics analysis of the SENP1 SUMO isopeptidase in pancreatic cancer. PMID:31602319
Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) overexpression in tumors predicts worse overall survival in hepatocellular carcinoma. PMID:31598161
Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines. PMID:31597922
PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies. PMID:31595832
Distinctive targetable genotypes of younger patients with lung adenocarcinoma: a cBioPortal for cancer genomics data base analysis. PMID:31594446
ADAM proteases: Emerging role and targeting of the non-catalytic domains. PMID:31593799
Outcomes of multimodal therapy in a large series of patients with anaplastic thyroid cancer. PMID:31593317
A rectal cancer organoid platform to study individual responses to chemoradiation. PMID:31591597
Bringing radiomics into a multi-omics framework for a comprehensive genotype-phenotype characterization of oncological diseases. PMID:31590671
Acetylcholine Receptor Activation as a Modulator of Glioblastoma Invasion. PMID:31590360
Genetic modification of primary human B cells to model high-grade lymphoma. PMID:31586074
S100A10 Is a Critical Mediator of GAS6/AXL-Induced Angiogenesis in Renal Cell Carcinoma. PMID:31585940
Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer. PMID:31585938
Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations. PMID:31585123
Diagnostic Utility of Next-Generation Sequencing for Disorders of Somatic Mosaicism: A Five-Year Cumulative Cohort. PMID:31585106
EWAS Data Hub: a resource of DNA methylation array data and metadata. PMID:31584095
Histone lysine methyltransferases in biology and disease. PMID:31582846
STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer. PMID:31581535
Clinical implications of ALDH1A1 and ALDH1A3 mRNA expression in melanoma subtypes. PMID:31580832
Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis. PMID:31576298
Bortezomib sensitivity is tissue dependent and high expression of the 20S proteasome precludes good response in malignant pleural mesothelioma. PMID:31576173
Screening and Identification of Potential Prognostic Biomarkers in Adrenocortical Carcinoma. PMID:31572440
Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53. PMID:31570706
Integration of Bioinformatics Resources Reveals the Therapeutic Benefits of Gemcitabine and Cell Cycle Intervention in SMAD4-Deleted Pancreatic Ductal Adenocarcinoma. PMID:31569425
Overexpression of TRMT12 may independently predict poor overall survival in patients with head and neck squamous cell carcinoma. PMID:31564910
FAT1, a direct transcriptional target of E2F1, suppresses cell proliferation, migration and invasion in esophageal squamous cell carcinoma. PMID:31564804
Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer. PMID:31562808
Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation. PMID:31560077
Retinoid X receptor gamma (RXRG) is an independent prognostic biomarker in ER-positive invasive breast cancer. PMID:31558802
Targeting lysosome function causes selective cytotoxicity in VHL-inactivated renal cell carcinomas. PMID:31556451
Liquid biopsies using pleural effusion-derived exosomal DNA in advanced lung adenocarcinoma. PMID:31555514
Vacuolar H+-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling. PMID:31554233
Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing. PMID:31553912
PIK3CA and MAP3K1 alterations imply luminal A status and are associated with clinical benefit from pan-PI3K inhibitor buparlisib and letrozole in ER+ metastatic breast cancer. PMID:31552290
Olfactory receptor gene abundance in invasive breast carcinoma. PMID:31551495
Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer. PMID:31551414
Genome-wide screening identifies novel genes implicated in cellular sensitivity to BRAFV600E expression. PMID:31548614
Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer. PMID:31548343
IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells. PMID:31548328
Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression. PMID:31548239
NT5E/CD73 as Correlative Factor of Patient Survival and Natural Killer Cell Infiltration in Glioblastoma. PMID:31547570
Chromosomal Density of Cancer Up-Regulated Genes, Aberrant Enhancer Activity and Cancer Fitness Genes Are Associated with Transcriptional Cis-Effects of Broad Copy Number Gains in Colorectal Cancer. PMID:31546890
Matched Whole-Genome Sequencing (WGS) and Whole-Exome Sequencing (WES) of Tumor Tissue with Circulating Tumor DNA (ctDNA) Analysis: Complementary Modalities in Clinical Practice. PMID:31546879
Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases. PMID:31545917
Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer. PMID:31545451
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass. PMID:31541927
GLS2 is protumorigenic in breast cancers. PMID:31541193
In Silico Drug Prescription for Targeting Cancer Patient Heterogeneity and Prediction of Clinical Outcome. PMID:31540260
Association of Tumor Protein p53 and Ataxia-Telangiectasia Mutated Comutation With Response to Immune Checkpoint Inhibitors and Mortality in Patients With Non-Small Cell Lung Cancer. PMID:31539077
A male-specific association between AGTR1 hypermethylation and coronary heart disease. PMID:31538912
Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets. PMID:31537895
A conserved Bcd1 interaction essential for box C/D snoRNP biogenesis. PMID:31537647
Multi-view based integrative analysis of gene expression data for identifying biomarkers. PMID:31534156
Transcriptional alterations in glioma result primarily from DNA methylation-independent mechanisms. PMID:31533980
Robust and interpretable PAM50 reclassification exhibits survival advantage for myoepithelial and immune phenotypes. PMID:31531391
A clinico-genomic analysis of soft tissue sarcoma patients reveals CDKN2A deletion as a biomarker for poor prognosis. PMID:31528332
A FAM83A Positive Feed-back Loop Drives Survival and Tumorigenicity of Pancreatic Ductal Adenocarcinomas. PMID:31527715
IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colorectal cancer. PMID:31527315
High expression of bone morphogenetic protein (BMP) 6 and BMP7 are associated with higher immune cell infiltration and better survival in estrogen receptor‑positive breast cancer. PMID:31524275
HiLDA: a statistical approach to investigate differences in mutational signatures. PMID:31523512
Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer. PMID:31523393
DGKζ Plays Crucial Roles in the Proliferation and Tumorigenicity of Human glioblastoma. PMID:31523189
Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation. PMID:31521603
ERBB3 mutations in cancer: biological aspects, prevalence and therapeutics. PMID:31519989
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma. PMID:31519915
Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma. PMID:31519898
Identification of differentially expressed genes between primary lung cancer and lymph node metastasis via bioinformatic analysis. PMID:31516588
Prognostic roles of mitochondrial transcription termination factors in non-small cell lung cancer. PMID:31516563
Predictive value of pseudouridine in prostate cancer. PMID:31511832
CytoConverter: a web-based tool to convert karyotypes to genomic coordinates. PMID:31510921
An Autocrine Wnt5a Loop Promotes NF-κB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma. PMID:31510045
Combining ERBB family and MET inhibitors is an effective therapeutic strategy in cutaneous malignant melanoma independent of BRAF/NRAS mutation status. PMID:31506424
Ado-trastuzumab emtansine (T-DM1) in patients with HER2-amplified tumors excluding breast and gastric/gastroesophageal junction (GEJ) adenocarcinomas: results from the NCI-MATCH trial (EAY131) subprotocol Q. PMID:31504139
Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response. PMID:31501315
ESR1-Stabilizing Long Noncoding RNA TMPO-AS1 Promotes Hormone-Refractory Breast Cancer Progression. PMID:31501276
Precise Immunodetection of PTEN Protein in Human Neoplasia. PMID:31501265
Discovery of a new pyrimidine synthesis inhibitor eradicating glioblastoma-initiating cells. PMID:31499527
Expression profile and prognostic values of STAT family members in non-small cell lung cancer. PMID:31497205
Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention? PMID:31496918
The relevance between the immune response-related gene module and clinical traits in head and neck squamous cell carcinoma. PMID:31496804
The ubiquitin ligase adaptor SPOP in cancer. PMID:31495053
Opportunities for new studies of nuclear DNA replication enzymology in budding yeast. PMID:31493018
Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival. PMID:31492840
Tumor-induced peripheral immunosuppression promotes brain metastasis in patients with non-small cell lung cancer. PMID:31489465
USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation. PMID:31488580
Regulation of histone methylation by automethylation of PRC2. PMID:31488576
An LTR retrotransposon-derived lncRNA interacts with RNF169 to promote homologous recombination. PMID:31486214
The Emerging Role of NANOG as an Early Cancer Risk Biomarker in Patients with Oral Potentially Malignant Disorders. PMID:31484317
Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis. PMID:31484072
Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis. PMID:31483918
Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. PMID:31483290
Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells. PMID:31481733
Tumor-Derived Peptidoglycan Recognition Protein 2 Predicts Survival and Antitumor Immune Responses in Hepatocellular Carcinoma. PMID:31479523
Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro. PMID:31477700
Identification and validation of a prognostic proteomic signature for cervical cancer. PMID:31477280
Therapeutic Effect of pHLIP-mediated CEACAM6 Gene Silencing in Lung Adenocarcinoma. PMID:31474761
The Dual Roles of the Atypical Protein Kinase Cs in Cancer. PMID:31474570
Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data. PMID:31472672
Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression. PMID:31471524
Comprehensive Next-Generation Sequencing Unambiguously Distinguishes Separate Primary Lung Carcinomas From Intrapulmonary Metastases: Comparison with Standard Histopathologic Approach. PMID:31471310
Frequency and outcomes of brain metastases in patients with HER2-mutant lung cancers. PMID:31469421
ERK1/2 signaling regulates the immune microenvironment and macrophage recruitment in glioblastoma. PMID:31467175
Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies. PMID:31467060
BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain Tumors. PMID:31466300
MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues. PMID:31466240
Coxsackievirus Type B3 Is a Potent Oncolytic Virus against KRAS-Mutant Lung Adenocarcinoma. PMID:31463367
BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer. PMID:31462713
WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. PMID:31462314
Telomere alterations in neurofibromatosis type 1-associated solid tumors. PMID:31462295
Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma. PMID:31462277
Analysis of Tumor Genomic Pathway Alterations Using Broad-Panel Next-Generation Sequencing in Surgically Resected Lung Adenocarcinoma. PMID:31455678
CDK4/6 inhibitors in advanced breast cancer, what is beyond? PMID:31452841
V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss. PMID:31452834
High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis. PMID:31452794
Screening and identification of potential target genes in head and neck cancer using bioinformatics analysis. PMID:31452775
Multi-kinase inhibitors and cisplatin for head and neck cancer treatment in vitro. PMID:31452723
The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes. PMID:31451538
Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance. PMID:31450721
Transcriptomic Analysis Identifies RNA Binding Proteins as Putative Regulators of Myelopoiesis and Leukemia. PMID:31448224
Genomic Landscape and Immune Microenvironment Features of Preinvasive and Early Invasive Lung Adenocarcinoma. PMID:31446140
SOX4: The unappreciated oncogene. PMID:31445218
A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma. PMID:31444368
For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors. PMID:31443495
The Prognosis Value of PIWIL1 and PIWIL2 Expression in Pancreatic Cancer. PMID:31443431
High expression of the vacuole membrane protein 1 (VMP1) is a potential marker of poor prognosis in HER2 positive breast cancer. PMID:31442252
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. PMID:31439867
Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination. PMID:31437751
Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia. PMID:31436048
Chronic iron exposure and c-Myc/H-ras-mediated transformation in fallopian tube cells alter the expression of EVI1, amplified at 3q26.2 in ovarian cancer. PMID:31434871
ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells. PMID:31434712
Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming. PMID:31433975
tRic: a user-friendly data portal to explore the expression landscape of tRNAs in human cancers. PMID:31432762
Impact of KRAS and TP53 Co-Mutations on Outcomes After First-Line Systemic Therapy Among Patients With STK11-Mutated Advanced Non-Small-Cell Lung Cancer. PMID:31428721
Compression-induced expression of glycolysis genes in CAFs correlates with EMT and angiogenesis gene expression in breast cancer. PMID:31428701
LSD1 Activates PI3K/AKT Signaling Through Regulating p85 Expression in Prostate Cancer Cells. PMID:31428587
Rho GTPases in cancer: friend or foe? PMID:31427738
The Role of the HOXA Gene Family in Acute Myeloid Leukemia. PMID:31426381
E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition. PMID:31424118
Identification of 9 key genes and small molecule drugs in clear cell renal cell carcinoma. PMID:31422942
Long noncoding RNA LINC01089 predicts clinical prognosis and inhibits cell proliferation and invasion through the Wnt/β-catenin signaling pathway in breast cancer. PMID:31417284
Adaptive Responses as Mechanisms of Resistance to BRAF Inhibitors in Melanoma. PMID:31416288
Cartilage oligomeric matrix protein in patients with osteoarthritis is independently associated with metastatic disease in prostate cancer. PMID:31413818
Verteporfin suppresses the proliferation, epithelial-mesenchymal transition and stemness of head and neck squamous carcinoma cells via inhibiting YAP1. PMID:31413738
Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression. PMID:31411736
DNA polymerase ζ in DNA replication and repair. PMID:31410467
New CXCR1/CXCR2 inhibitors represent an effective treatment for kidney or head and neck cancers sensitive or refractory to reference treatments. PMID:31410218
The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation. PMID:31409643
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. PMID:31408619
Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy. PMID:31406302
The Hippo pathway modulates resistance to BET proteins inhibitors in lung cancer cells. PMID:31406246
Parkin is transcriptionally regulated by the aryl hydrocarbon receptor: Impact on α-synuclein protein levels. PMID:31404530
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer. PMID:31404287
Comprehensive analysis of peroxiredoxins expression profiles and prognostic values in breast cancer. PMID:31402980
MiR-486-5p Serves as a Good Biomarker in Nonsmall Cell Lung Cancer and Suppresses Cell Growth With the Involvement of a Target PIK3R1. PMID:31402930
Mechanical Stabilization of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex. PMID:31402305
A STAT3-based gene signature stratifies glioma patients for targeted therapy. PMID:31399589
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer. PMID:31399573
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. PMID:31398338
Heterocellular gene signatures reveal luminal-A breast cancer heterogeneity and differential therapeutic responses. PMID:31396557
ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis. PMID:31395079
Identification of significant gene and pathways involved in HBV-related hepatocellular carcinoma by bioinformatics analysis. PMID:31392101
ClickGene: an open cloud-based platform for big pan-cancer data genome-wide association study, visualization and exploration. PMID:31391866
LINC00346 promotes pancreatic cancer progression through the CTCF-mediated Myc transcription. PMID:31391552
Genomic and clinical characterization of pulmonary-only metastatic prostate cancer: A unique molecular subtype. PMID:31389628
Cyclin-dependent kinase inhibitor 2B gene is associated with the sensitivity of hepatoma cells to Sorafenib. PMID:31388306
DAXX Suppresses Tumor-Initiating Cells in Estrogen Receptor-Positive Breast Cancer Following Endocrine Therapy. PMID:31387918
CpG promoter hypo-methylation and up-regulation of microRNA-190b in hormone receptor-positive breast cancer. PMID:31384394
Characterization of the prognostic values of the NDRG family in gastric cancer. PMID:31384305
Identifying Cancers Impacted by CDK8/19. PMID:31382571
Evaluation of MT Family Isoforms as Potential Biomarker for Predicting Progression and Prognosis in Gastric Cancer. PMID:31380415
Prognostic Significance of Potential Immune Checkpoint Member HHLA2 in Human Tumors: A Comprehensive Analysis. PMID:31379814
C-Jun drives melanoma progression in PTEN wild type melanoma cells. PMID:31378787
Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition. PMID:31378590
Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade. PMID:31375522
Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability. PMID:31374965
Association of C8orf4 expression with its methylation status, aberrant β-catenin expression, and the development of cervical squamous cell carcinoma. PMID:31374065
The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression. PMID:31372497
BRN4 Is a Novel Driver of Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer and Is Selectively Released in Extracellular Vesicles with BRN2. PMID:31371344
Claudin-low-like mouse mammary tumors show distinct transcriptomic patterns uncoupled from genomic drivers. PMID:31366361
TP53 DNA Binding Domain Mutations Predict Progression-Free Survival of Bevacizumab Therapy in Metastatic Colorectal Cancer. PMID:31366114
Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas. PMID:31365877
A dual luciferase assay for evaluation of skin sensitizing potential of medical devices. PMID:31364015
Detailed modeling of positive selection improves detection of cancer driver genes. PMID:31363082
Gene Expression Analyses in Breast Cancer: Sample Matters. PMID:31360851
Genome atlas analysis based profiling of Akt pathway genes in the early and advanced human prostate cancer. PMID:31360736
CDK12 inactivation across solid tumors: an actionable genetic subtype. PMID:31360735
The landscape of novel and complementary targets for immunotherapy: an analysis of gene expression in the tumor microenvironment. PMID:31360302
Loss of the tumor suppressor, Tp53, enhances the androgen receptor-mediated oncogenic transformation and tumor development in the mouse prostate. PMID:31358900
Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis. PMID:31357676
Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project. PMID:31357599
A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis. PMID:31357169
Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome instability. PMID:31350889
Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer. PMID:31350446
Establishing a prognostic threshold for total copy number variation within adult IDH-mutant grade II/III astrocytomas. PMID:31349875
Oncogenic effect of PHLDB2 is associated with epithelial-mesenchymal transition and E-cadherin regulation in colorectal cancer. PMID:31346319
Systematic analysis of the intersection of disease mutations with protein modifications. PMID:31345222
Big Data Approaches for Modeling Response and Resistance to Cancer Drugs. PMID:31342013
Head and Neck Cancer Immunotherapy beyond the Checkpoint Blockade. PMID:31340724
In Vivo Assessment of VCAM-1 Expression by SPECT/CT Imaging in Mice Models of Human Triple Negative Breast Cancer. PMID:31340603
Molecular Mechanisms of p63-Mediated Squamous Cancer Pathogenesis. PMID:31340447
The molecular genetic make-up of male breast cancer. PMID:31340200
Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer. PMID:31340155
Role of miR-214 in regulation of β-catenin and the malignant phenotype of melanoma. PMID:31338875
Prognostic Score Predicts Survival in HPV-Negative Head and Neck Squamous Cell Cancer Patients. PMID:31337965
A Mutation in Histone H2B Represents a New Class of Oncogenic Driver. PMID:31337617
SCF(FBXW7)-mediated degradation of p53 promotes cell recovery after UV-induced DNA damage. PMID:31337255
Multi-omic Dissection of Oncogenically Active Epiproteomes Identifies Drivers of Proliferative and Invasive Breast Tumors. PMID:31336272
The Cajal Body Protein WRAP53β Prepares the Scene for Repair of DNA Double-Strand Breaks by Regulating Local Ubiquitination. PMID:31334247
Upregulation of nucleoprotein AHNAK is associated with poor outcome of pancreatic ductal adenocarcinoma prognosis via mediating epithelial-mesenchymal transition. PMID:31333803
Transcriptome profiling-based identification of prognostic subtypes and multi-omics signatures of glioblastoma. PMID:31332251
Functional genomics identifies predictive markers and clinically actionable resistance mechanisms to CDK4/6 inhibition in bladder cancer. PMID:31331377
Emerging Therapeutic Opportunities Based on Current Knowledge of Uveal Melanoma Biology. PMID:31330784
Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy. PMID:31330086
Targeting PDZ-binding kinase is anti-tumorigenic in novel preclinical models of ACC. PMID:31325906
Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer. PMID:31324173
Single-Nucleotide Polymorphisms Sequencing Identifies Candidate Functional Variants at Prostate Cancer Risk Loci. PMID:31323811
NSD1 mutations by HPV status in head and neck cancer: differences in survival and response to DNA-damaging agents. PMID:31321084
FGFR3S249C mutation promotes chemoresistance by activating Akt signaling in bladder cancer cells. PMID:31316618
BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors. PMID:31316060
Overexpression of ICAM-1 Predicts Poor Survival in High-Grade Serous Ovarian Carcinoma: A Study Based on TCGA and GEO Databases and Tissue Microarray. PMID:31312656
Membrane protein-regulated networks across human cancers. PMID:31311925
PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization. PMID:31311869
Molecular prognosticators in clinically and pathologically distinct cohorts of head and neck squamous cell carcinoma-A meta-analysis approach. PMID:31310629
Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML. PMID:31309149
Rgnef promotes ovarian tumor progression and confers protection from oxidative stress. PMID:31308489
Integration and Analysis of CPTAC Proteomics Data in the Context of Cancer Genomics in the cBioPortal. PMID:31308250
Improved detection of gene fusions by applying statistical methods reveals oncogenic RNA cancer drivers. PMID:31308241
APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC. PMID:31307523
CEMIP upregulates BiP to promote breast cancer cell survival in hypoxia. PMID:31303964
Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. PMID:31303424
The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease. PMID:31302748
Acquired EGFR L718V Mutation as the Mechanism for Osimertinib Resistance in a T790M-Negative Non-Small-Cell Lung Cancer Patient. PMID:31301016
CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes. PMID:31300537
Circulating Tumor DNA Profiling in Small-Cell Lung Cancer Identifies Potentially Targetable Alterations. PMID:31300452
Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A. PMID:31300350
XPNPEP2 is associated with lymph node metastasis in prostate cancer patients. PMID:31296901
Functional divergence caused by mutations in an energetic hotspot in ERK2. PMID:31296562
CONFIGURE: A pipeline for identifying context specific regulatory modules from gene expression data and its application to breast cancer. PMID:31296219
Inhibition of Phosphatidylinositol 3-kinase (PI3K) Signaling Synergistically Potentiates Antitumor Efficacy of Paclitaxel and Overcomes Paclitaxel-Mediated Resistance in Cervical Cancer. PMID:31295843
HeartBioPortal. PMID:31294639
Ellagic acid exerts antitumor effects via the PI3K signaling pathway in endometrial cancer. PMID:31293633
Emergence of ERBB2 Mutation as a Biomarker and an Actionable Target in Solid Cancers. PMID:31292270
Characterizing responsive and refractory orthotopic mouse models of hepatocellular carcinoma in cancer immunotherapy. PMID:31291357
BRAFV600E-induced KRT19 expression in thyroid cancer promotes lymph node metastasis via EMT. PMID:31289571
Inhibition of insulin-like growth factor 1 signaling synergistically enhances the tumor suppressive role of triptolide in triple-negative breast cancer cells. PMID:31289559
DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer. PMID:31289523
The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde? †. PMID:31288625
mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer. PMID:31288154
Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research. PMID:31287543
Stability and sub-cellular localization of DNA polymerase β is regulated by interactions with NQO1 and XRCC1 in response to oxidative stress. PMID:31287140
Septin 9 isoforms promote tumorigenesis in mammary epithelial cells by increasing migration and ECM degradation through metalloproteinase secretion at focal adhesions. PMID:31285548
A functional genetic screen defines the AKT-induced senescence signaling network. PMID:31285545
FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation. PMID:31285543
Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics. PMID:31284662
PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness. PMID:31279780
GEDS: A Gene Expression Display Server for mRNAs, miRNAs and Proteins. PMID:31277321
miR-340-5p Suppresses Aggressiveness in Glioblastoma Multiforme by Targeting Bcl-w and Sox2. PMID:31272074
Pembrolizumab in men with heavily treated metastatic castrate-resistant prostate cancer. PMID:31270961
SOX4 regulates invasion of bladder cancer cells via repression of WNT5a. PMID:31268162
Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma. PMID:31266951
Whole-exome sequencing of ovarian cancer families uncovers putative predisposition genes. PMID:31265121
FGFR4 overexpression and hotspot mutations in metastatic ER+ breast cancer are enriched in the lobular subtype. PMID:31263748
Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments. PMID:31263265
CD97 expression is associated with poor overall survival in acute myeloid leukemia. PMID:31260716
Loss of function Cbl-c mutations in solid tumors. PMID:31260484
Clustered microRNAs hsa-miR-221-3p/hsa-miR-222-3p and their targeted genes might be prognostic predictors for hepatocellular carcinoma. PMID:31258758
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling. PMID:31253801
Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma. PMID:31252679
Modelling cancer progression using Mutual Hazard Networks. PMID:31250881
Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review. PMID:31249452
FGFR2-Altered Gastroesophageal Adenocarcinomas Are an Uncommon Clinicopathologic Entity with a Distinct Genomic Landscape. PMID:31249137
ERBB2 Regulates MED24 during Cancer Progression in Mice with Pten and Smad4 Deletion in the Pulmonary Epithelium. PMID:31248101
Integration of Random Forest Classifiers and Deep Convolutional Neural Networks for Classification and Biomolecular Modeling of Cancer Driver Mutations. PMID:31245384
A liver-specific lncRNA, FAM99B, suppresses hepatocellular carcinoma progression through inhibition of cell proliferation, migration, and invasion. PMID:31243545
Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer. PMID:31243372
FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. PMID:31243370
Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer. PMID:31243151
Targeting the Oncogenic FGF-FGFR Axis in Gastric Carcinogenesis. PMID:31242658
Parallel-Reaction-Monitoring-Based Proteome-Wide Profiling of Differential Kinase Protein Expression during Prostate Cancer Metastasis in Vitro. PMID:31241916
Direct Ras G12C inhibitors: crossing the rubicon. PMID:31239544
KLF4 as a rheostat of osteolysis and osteogenesis in prostate tumors in the bone. PMID:31239516
Anticancer Effects of Emodin on HepG2 Cell: Evidence from Bioinformatic Analysis. PMID:31236404
The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression. PMID:31235595
ASC-J9® increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-κB survival signals. PMID:31234917
Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications. PMID:31231212
Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype. PMID:31230251
ATRX Mutations in Pineal Parenchymal Tumors of Intermediate Differentiation. PMID:31225581
Amplification of lncRNA PVT1 promotes ovarian cancer proliferation by binding to miR-140. PMID:31222482
The chromatin remodeler Chd1 regulates cohesin in budding yeast and humans. PMID:31222142
Systems-level Analysis Reveals Multiple Modulators of Epithelial-mesenchymal Transition and Identifies DNAJB4 and CD81 as Novel Metastasis Inducers in Breast Cancer. PMID:31221721
Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer. PMID:31221207
A subtype of oral, laryngeal, esophageal, and lung, squamous cell carcinoma with high levels of TrkB-T1 neurotrophin receptor mRNA. PMID:31221127
GATA3 Truncating Mutations Promote Cistromic Re-Programming In Vitro, but Not Mammary Tumor Formation in Mice. PMID:31218575
Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes. PMID:31217899
ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells. PMID:31217031
TP53 structural variants in metastatic prostatic carcinoma. PMID:31216325
The identification of a TNBC liver metastasis gene signature by sequential CTC-xenograft modeling. PMID:31216110
TuBA: Tunable biclustering algorithm reveals clinically relevant tumor transcriptional profiles in breast cancer. PMID:31216036
Distribution differences in prognostic copy number alteration profiles in IDH-wild-type glioblastoma cause survival discrepancies across cohorts. PMID:31215469
Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer. PMID:31215437
PP2A: A Promising Biomarker and Therapeutic Target in Endometrial Cancer. PMID:31214504
Revisiting Non-BRCA1/2 Familial Whole Exome Sequencing Datasets Implicates NCK1 as a Cancer Gene. PMID:31214250
Negative regulators of STAT3 signaling pathway in cancers. PMID:31213912
Expressions of HLA Class II Genes in Cutaneous Melanoma Were Associated with Clinical Outcome: Bioinformatics Approaches and Systematic Analysis of Public Microarray and RNA-Seq Datasets. PMID:31212865
Survival analysis and functional annotation of long non-coding RNAs in lung adenocarcinoma. PMID:31211495
The potential markers of endocrine resistance among HR+ /HER2+ breast cancer patients. PMID:31209793
Integrative analysis of common genes and driver mutations implicated in hormone stimulation for four cancers in women. PMID:31205821
FAM84B promotes prostate tumorigenesis through a network alteration. PMID:31205500
NF1 mutations identify molecular and clinical subtypes of lung adenocarcinomas. PMID:31199580
Aberrantly expressed PLOD1 promotes cancer aggressiveness in bladder cancer: a potential prognostic marker and therapeutic target. PMID:31199049
Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer. PMID:31198906
ALDH1A3-regulated long non-coding RNA NRAD1 is a potential novel target for triple-negative breast tumors and cancer stem cells. PMID:31197235
Role of the DNA damage response in prostate cancer formation, progression and treatment. PMID:31197228
The ion channels and transporters gene expression profile indicates a shift in excitability and metabolisms during malignant progression of Follicular Lymphoma. PMID:31197180
CK2 Pro-Survival Role in Prostate Cancer Is Mediated via Maintenance and Promotion of Androgen Receptor and NFκB p65 Expression. PMID:31197122
Loss of Fbxw7 synergizes with activated Akt signaling to promote c-Myc dependent cholangiocarcinogenesis. PMID:31195063
Two factor authentication: Asf1 mediates crosstalk between H3 K14 and K56 acetylation. PMID:31194870
Identification of novel biomarkers and candidate small molecule drugs in non-small-cell lung cancer by integrated microarray analysis. PMID:31190860
Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation. PMID:31188872
NOTCH2/NOTCH3/DLL3/MAML1/ADAM17 signaling network is associated with ovarian cancer. PMID:31186700
Differential Expression Profile of NLRs and AIM2 in Glioma and Implications for NLRP12 in Glioblastoma. PMID:31186453
Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence. PMID:31186408
β-Catenin Activation Promotes Immune Escape and Resistance to Anti-PD-1 Therapy in Hepatocellular Carcinoma. PMID:31186238
Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. PMID:31185211
Identification of CTRP1 as a Prognostic Biomarker and Oncogene in Human Glioblastoma. PMID:31183364
AXL Is a Novel Predictive Factor and Therapeutic Target for Radioactive Iodine Refractory Thyroid Cancer. PMID:31181609
PLEKHO1 knockdown inhibits RCC cell viability in vitro and in vivo, potentially by the Hippo and MAPK/JNK pathways. PMID:31180521
Identification of Specific Lysines and Arginines That Mediate Angiomotin Membrane Association. PMID:31179409
Total copy number variation as a prognostic factor in adult astrocytoma subtypes. PMID:31177992
Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations. PMID:31175097
Identification of key candidate genes involved in melanoma metastasis. PMID:31173190
Carbonic anhydrases as disease markers. PMID:31172829
Illuminating the Onco-GPCRome: Novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy. PMID:31171722
High expression of Annexin A2 is associated with DNA repair, metabolic alteration, and worse survival in pancreatic ductal adenocarcinoma. PMID:31171367
PROM1 and PROM2 expression differentially modulates clinical prognosis of cancer: a multiomics analysis. PMID:31164716
WDSPdb: an updated resource for WD40 proteins. PMID:31161214
Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition. PMID:31158244
Characterization of upregulated adhesion GPCRs in acute myeloid leukemia. PMID:31153896
Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma. PMID:31151416
MAGE cancer-testis antigens protect the mammalian germline under environmental stress. PMID:31149633
EXPRESSION OF MENIN IN THE HUMAN THYROID GLAND. PMID:31149167
High OGT activity is essential for MYC-driven proliferation of prostate cancer cells. PMID:31149037
MicroRNA-335/ID4 dysregulation predicts clinical outcome and facilitates leukemogenesis by activating PI3K/Akt signaling pathway in acute myeloid leukemia. PMID:31147526
Novel secretome-to-transcriptome integrated or secreto-transcriptomic approach to reveal liquid biopsy biomarkers for predicting individualized prognosis of breast cancer patients. PMID:31146747
Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway. PMID:31146385
An overview of publicly available patient-centered prostate cancer datasets. PMID:31143673
Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility. PMID:31142743
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. PMID:31142647
The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis. PMID:31142515
Significance of PTEN Mutation in Cellular Process, Prognosis, and Drug Selection in Clear Cell Renal Cell Carcinoma. PMID:31139560
Defining molecular risk in ALK+ NSCLC. PMID:31139322
Identification of hub genes and therapeutic drugs in esophageal squamous cell carcinoma based on integrated bioinformatics strategy. PMID:31139019
Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma. PMID:31139015
RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression. PMID:31138663
A Novel Set of WNT Pathway Effectors as a Predictive Marker of Uterine Corpus Endometrial Carcinoma-Study Based on Weighted Co-expression Matrices. PMID:31134156
Identification of Hub Genes Associated With Progression and Prognosis in Patients With Bladder Cancer. PMID:31134129
Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis. PMID:31133044
Hematopoietic-substrate-1 associated protein X-1 (HAX-1) regulates liver cancer cells growth, metastasis, and angiogenesis through Akt. PMID:31132019
Genetic Alterations Detected in Cell-Free DNA Are Associated With Enzalutamide and Abiraterone Resistance in Castration-Resistant Prostate Cancer. PMID:31131348
Metadherin: A Therapeutic Target in Multiple Cancers. PMID:31131259
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma. PMID:31131257
COMPASS Ascending: Emerging clues regarding the roles of MLL3/KMT2C and MLL2/KMT2D proteins in cancer. PMID:31128216
Tumor-associated antigens identified early in mouse mammary tumor development can be effective vaccine targets. PMID:31126858
SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function. PMID:31125786
Genomic Characterization of Prostatic Ductal Adenocarcinoma Identifies a High Prevalence of DNA Repair Gene Mutations. PMID:31123724
Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression. PMID:31123087
Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer. PMID:31122207
The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21. PMID:31116991
Neuroblastoma RAS viral oncogene homolog mRNA is differentially spliced to give five distinct isoforms: implications for melanoma therapy. PMID:31116161
Combining the Specific Anti-MUC1 Antibody TAB004 and Lip-MSA-IL-2 Limits Pancreatic Cancer Progression in Immune Competent Murine Models of Pancreatic Ductal Adenocarcinoma. PMID:31114758
Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma. PMID:31114500
CDKN3 promotes tumor progression and confers cisplatin resistance via RAD51 in esophageal cancer. PMID:31114363
A key genomic subtype associated with lymphovascular invasion in invasive breast cancer. PMID:31114020
BRD4 Regulates Metastatic Potential of Castration-Resistant Prostate Cancer through AHNAK. PMID:31110158
Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer. PMID:31107239
A novel conserved family of Macro-like domains-putative new players in ADP-ribosylation signaling. PMID:31106069
Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets. PMID:31105872
Characterization of cancer-associated IDH2 mutations that differ in tumorigenicity, chemosensitivity and 2-hydroxyglutarate production. PMID:31105869
APPBP2 enhances non-small cell lung cancer proliferation and invasiveness through regulating PPM1D and SPOP. PMID:31105033
LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML. PMID:31105032
Low expression of WWC1, a tumor suppressor gene, is associated with aggressive breast cancer and poor survival outcome. PMID:31102318
Loss of Disabled-2 Expression in Pancreatic Cancer Progression. PMID:31101868
Heat shock proteins create a signature to predict the clinical outcome in breast cancer. PMID:31101846
The LIM protein Ajuba/SP1 complex forms a feed forward loop to induce SP1 target genes and promote pancreatic cancer cell proliferation. PMID:31101117
Discovery of CDK5 Inhibitors through Structure-Guided Approach. PMID:31098000
c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma. PMID:31097685
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. PMID:31097636
Mining and validating the expression pattern and prognostic value of acetylcholine receptors in non-small cell lung cancer. PMID:31096457
Allelic Switching of DLX5, GRB10, and SVOPL during Colorectal Cancer Tumorigenesis. PMID:31093489
The cylindromatosis (CYLD) gene and head and neck tumorigenesis. PMID:31093340
Prognostic Value of BIRC5 in Lung Adenocarcinoma Lacking EGFR, KRAS, and ALK Mutations by Integrated Bioinformatics Analysis. PMID:31093306
Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis. PMID:31093284
Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data. PMID:31092827
Titin mutation associated with responsiveness to checkpoint blockades in solid tumors. PMID:31092729
Mutplot: An easy-to-use online tool for plotting complex mutation data with flexibility. PMID:31091262
The molecular landscape of the University of Michigan laryngeal squamous cell carcinoma cell line panel. PMID:31090975
[From panel diagnostics to comprehensive genomic analysis : Infobesity or empowerment?]. PMID:31089797
GIDB: a knowledge database for the automated curation and multidimensional analysis of molecular signatures in gastrointestinal cancer. PMID:31089686
JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression. PMID:31089135
Human PRPF40B regulates hundreds of alternative splicing targets and represses a hypoxia expression signature. PMID:31088860
Radiation-Induced DNA Damage Cooperates with Heterozygosity of TP53 and PTEN to Generate High-Grade Gliomas. PMID:31088835
Identification of novel biomarkers and small molecule drugs in human colorectal cancer by microarray and bioinformatics analysis. PMID:31087508
Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling. PMID:31087223
FANCD2 Binding to H4K20me2 via a Methyl-Binding Domain Is Essential for Efficient DNA Cross-Link Repair. PMID:31085681
The dynamic conformational landscape of the protein methyltransferase SETD8. PMID:31081496
INKA2, a novel p53 target that interacts with the serine/threonine kinase PAK4. PMID:31081062
Phospho‑STAT1 expression as a potential biomarker for anti‑PD‑1/anti‑PD‑L1 immunotherapy for breast cancer. PMID:31081058
CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule. PMID:31080802
Hyper-O-GlcNAcylation promotes epithelial-mesenchymal transition in endometrial cancer cells. PMID:31080560
Mutation profiles of follicular thyroid tumors by targeted sequencing. PMID:31077238
Dissecting TSC2-mutated renal and hepatic angiomyolipomas in an individual with ARID1B-associated intellectual disability. PMID:31077186
A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells. PMID:31076498
USP9X-mediated deubiquitination of B-cell CLL/lymphoma 9 potentiates Wnt signaling and promotes breast carcinogenesis. PMID:31073027
Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity. PMID:31072879
Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer. PMID:31072371
Focal Adhesion Kinase and β-Catenin Cooperate to Induce Hepatocellular Carcinoma. PMID:31069844
WISP1 is associated to advanced disease, EMT and an inflamed tumor microenvironment in multiple solid tumors. PMID:31069142
Next-generation characterization of the Cancer Cell Line Encyclopedia. PMID:31068700
A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1. PMID:31068365
The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer. PMID:31067569
Tumor genomic alterations in severe-combined immunodeficiency bare-lymphocyte syndrome genes are associated with high mutational burden and disproportional neo-antigen rates. PMID:31064401
Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition. PMID:31064120
Anchorage-independent growth conditions reveal a differential SOS2 dependence for transformation and survival in RAS-mutant cancer cells. PMID:31062644
Genomic correlates of clinical outcome in advanced prostate cancer. PMID:31061129
Expression and prognostic value of NSD1 and SETD2 in pancreatic ductal adenocarcinoma and its precursor lesions. PMID:31060750
A TMEFF2-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer. PMID:31060542
Genomic Profiling of the Steroidogenic Acute Regulatory Protein in Breast Cancer: In Silico Assessments and a Mechanistic Perspective. PMID:31060224
Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy. PMID:31059199
Comprehensive genomic and prognostic analysis of the IL‑17 family genes in lung cancer. PMID:31059089
Prospective molecular mechanism of COL5A1 in breast cancer based on a microarray, RNA sequencing and immunohistochemistry. PMID:31059074
Five miRNAs-mediated PIEZO2 downregulation, accompanied with activation of Hedgehog signaling pathway, predicts poor prognosis of breast cancer. PMID:31058608
Prognostic Role of TMED3 in Clear Cell Renal Cell Carcinoma: A Retrospective Multi-Cohort Analysis. PMID:31057605
Prognostic significance of EIF4G1 in patients with pancreatic ductal adenocarcinoma. PMID:31043796
RB constrains lineage fidelity and multiple stages of tumour progression and metastasis. PMID:31043741
Prognostic role of ARID1A negative expression in gastric cancer. PMID:31043675
TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease. PMID:31043488
Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. PMID:31042473
Exome Sequencing of a Primary Ovarian Insufficiency Cohort Reveals Common Molecular Etiologies for a Spectrum of Disease. PMID:31042289
The multiple roles of the unfolded protein response regulator IRE1α in cancer. PMID:31041814
Inferring cancer dependencies on metabolic genes from large-scale genetic screens. PMID:31039782
Downregulation of CYB5D2 is associated with breast cancer progression. PMID:31036830
Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer. PMID:31036156
PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma. PMID:31036078
Clinico-pathological associations and concomitant mutations of the RAS/RAF pathway in metastatic colorectal cancer. PMID:31036005
Aberrant Rac pathway signalling in glioblastoma. PMID:31032735
Whole exome sequencing reveals mutations in FAT1 tumor suppressor gene clinically impacting on peripheral T-cell lymphoma not otherwise specified. PMID:31028364
RAC1 Takes the Lead in Solid Tumors. PMID:31027363
Differential Activation of ERK Signaling in HPV-Related Oropharyngeal Squamous Cell Carcinoma. PMID:31027243
UNR/CSDE1 Expression Is Critical to Maintain Invasive Phenotype of Colorectal Cancer through Regulation of c-MYC and Epithelial-to-Mesenchymal Transition. PMID:31027221
Complicated prognostic values of CCL28 in breast cancer by subtype. PMID:31019765
Interchromosomal Translocations as a Means to Map Chromosome Territories in Breast Cancer. PMID:31019364
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling. PMID:31019297
In silico learning of tumor evolution through mutational time series. PMID:31015295
MicroRNA-92 Expression in CD133+ Melanoma Stem Cells Regulates Immunosuppression in the Tumor Microenvironment via Integrin-Dependent Activation of TGFβ. PMID:31015227
Long Non-Coding RNA ZFAS1 as a Novel Potential Biomarker for Predicting the Prognosis of Thyroid Cancer. PMID:31012438
High Expression of Pseudogene PTTG3P Indicates a Poor Prognosis in Human Breast Cancer. PMID:31011629
Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer. PMID:31010205
An SH3PX1-Dependent Endocytosis-Autophagy Network Restrains Intestinal Stem Cell Proliferation by Counteracting EGFR-ERK Signaling. PMID:31006650
Isocitrate dehydrogenase1 mutation reduces the pericyte coverage of microvessels in astrocytic tumours. PMID:31004262
Upregulation of MicroRNA-21 promotes tumorigenesis of prostate cancer cells by targeting KLF5. PMID:31002531
Transcriptional silencing of centromere repeats by heterochromatin safeguards chromosome integrity. PMID:30997531
Analysis of cyclin E co-expression genes reveals nuclear transcription factor Y subunit alpha is an oncogene in gastric cancer. PMID:30993263
A Human Organotypic Microfluidic Tumor Model Permits Investigation of the Interplay between Patient-Derived Fibroblasts and Breast Cancer Cells. PMID:30992322
Systematic Multiomics Analysis of Alterations in C1QBP mRNA Expression and Relevance for Clinical Outcomes in Cancers. PMID:30991713
Expression of GLUT1 in Pseudopalisaded and Perivascular Tumor Cells Is an Independent Prognostic Factor for Patients With Glioblastomas. PMID:30990881
The role of IRAK1 in breast cancer patients treated with neoadjuvant chemotherapy. PMID:30988621
Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells. PMID:30987626
CDK11 Loss Induces Cell Cycle Dysfunction and Death of BRAF and NRAS Melanoma Cells. PMID:30987032
Remodeling the cancer epigenome: mutations in the SWI/SNF complex offer new therapeutic opportunities. PMID:30986130
Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer. PMID:30984543
Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock. PMID:30982898
Human LC3 and GABARAP subfamily members achieve functional specificity via specific structural modulations. PMID:30982432
Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas. PMID:30979734
Reduced FRG1 expression promotes prostate cancer progression and affects prostate cancer cell migration and invasion. PMID:30975102
Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses. PMID:30975030
Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies. PMID:30974124
MAPK pathway activity plays a key role in PD-L1 expression of lung adenocarcinoma cells. PMID:30972766
Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment. PMID:30970447
E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer. PMID:30967995
Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness. PMID:30967630
DNA Repair Gene Expression Adjusted by the PCNA Metagene Predicts Survival in Multiple Cancers. PMID:30965671
Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients. PMID:30963401
Benefit from anti-EGFRs in RAS and BRAF wild-type metastatic transverse colon cancer: a clinical and molecular proof of concept study. PMID:30962964
An age-based, RNA expression paradigm for survival biomarker identification for pediatric neuroblastoma and acute lymphoblastic leukemia. PMID:30962767
Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer. PMID:30956167
Interleukin 32 expression in human melanoma. PMID:30953519
Changes of N6-methyladenosine modulators promote breast cancer progression. PMID:30953473
An unbiased in vitro screen for activating epidermal growth factor receptor mutations. PMID:30952700
Tissue-Specific Oncogenic Activity of KRASA146T. PMID:30952657
Efficacy of Combined VEGFR1-3, PDGFα/β, and FGFR1-3 Blockade Using Nintedanib for Esophagogastric Cancer. PMID:30952642
Overexpression of PARPBP Correlates with Tumor Progression and Poor Prognosis in Hepatocellular Carcinoma. PMID:30949905
Risk of cognition alteration and emotional frailty via circulating transcriptome in treatment naïve head and neck squamous cell cancer patients. PMID:30949427
Nuclear factor-erythroid 2-related factor 3 (NRF3) is low expressed in colorectal cancer and its down-regulation promotes colorectal cancer malignance through activating EGFR and p38/MAPK. PMID:30949407
VNN3 is a potential novel biomarker for predicting prognosis in clear cell renal cell carcinoma. PMID:30949398
G Protein γ subunit 7 loss contributes to progression of clear cell renal cell carcinoma. PMID:30945310
Evaluation of the prognostic significances of γ-secretase genes in pancreatic cancer. PMID:30944650
Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles. PMID:30943406
Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma. PMID:30942445
Tumor mutation burden and recurrent tumors in hereditary lung cancer. PMID:30941903
Phase II Study of Lenvatinib in Patients With Progressive, Recurrent or Metastatic Adenoid Cystic Carcinoma. PMID:30939095
Data and knowledge management in translational research: implementation of the eTRIKS platform for the IMI OncoTrack consortium. PMID:30935364
The Role of ZNF143 in Breast Cancer Cell Survival Through the NAD(P)H Quinone Dehydrogenase 1⁻p53⁻Beclin1 Axis Under Metabolic Stress. PMID:30935019
Expression patterns and the prognostic value of the SMYD family members in human breast carcinoma using integrative bioinformatics analysis. PMID:30930987
Genomic Drivers of Poor Prognosis and Enzalutamide Resistance in Metastatic Castration-resistant Prostate Cancer. PMID:30928160
PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise? PMID:30925702
Genomic signature of parity in the breast of premenopausal women. PMID:30922380
MicroRNA-4417 is a tumor suppressor and prognostic biomarker for triple-negative breast cancer. PMID:30922194
Identification of gene-phenotype connectivity associated with flavanone naringenin by functional network analysis. PMID:30918758
The Kinome of Human Alveolar Type II and Basal Cells, and Its Reprogramming in Lung Cancer. PMID:30917006
Functional Diversity of p53 in Human and Wild Animals. PMID:30915036
FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis. PMID:30914801
Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells. PMID:30914776
The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy. PMID:30914656
Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients. PMID:30914425
Genomic Common Data Model for Seamless Interoperation of Biomedical Data in Clinical Practice: Retrospective Study. PMID:30912749
PPARγ inhibition regulates the cell cycle, proliferation and motility of bladder cancer cells. PMID:30912275
Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. PMID:30911680
FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels. PMID:30911166
FAM83D is associated with gender, AJCC stage, overall survival and disease-free survival in hepatocellular carcinoma. PMID:30910840
MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma. PMID:30910803
The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas. PMID:30908539
Systematic Survey of the Role of IGF in the Link Between Diabetes and Cancer. PMID:30906876
Role of pre-miR-532 (miR-532-5p and miR-532-3p) in regulation of gene expression and molecular pathogenesis in renal cell carcinoma. PMID:30906802
Network Pharmacology Analysis of Damnacanthus indicus C.F.Gaertn in Gene-Phenotype. PMID:30906409
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer. PMID:30905761
FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. PMID:30903103
Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications. PMID:30902996
Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC. PMID:30902071
Origin of mutations in genes associated with human glioblastoma multiform cancer: random polymerase errors versus deamination. PMID:30899826
Depletion of H3K79 methyltransferase Dot1L promotes cell invasion and cancer stem-like cell property in ovarian cancer. PMID:30899413
STOML2 as a novel prognostic biomarker modulates cell proliferation, motility and chemo-sensitivity via IL6-Stat3 pathway in head and neck squamous cell carcinoma. PMID:30899371
Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells. PMID:30898113
A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers. PMID:30897760
Diagnostic and prognostic value of CEP55 in clear cell renal cell carcinoma as determined by bioinformatics analysis. PMID:30896867
Genome-scale integrated analysis to identify prospective molecular mechanisms and therapeutic targets in isocitrate dehydrogenase 2 R140Q-mutated acute myeloid leukemia. PMID:30896832
The expanding landscape of 'oncohistone' mutations in human cancers. PMID:30894748
A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma. PMID:30894629
Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer. PMID:30894499
DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination. PMID:30893604
DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. PMID:30889383
S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2. PMID:30885944
NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer. PMID:30885209
MiR-1-3p Inhibits Lung Adenocarcinoma Cell Tumorigenesis via Targeting Protein Regulator of Cytokinesis 1. PMID:30881920
F-box/WD-40 repeat-containing protein 7: A potential target in the progression and treatment of gastrointestinal malignancy. PMID:30881487
An immunosuppressive macrophage profile attenuates the prognostic impact of CD20-positive B cells in human soft tissue sarcoma. PMID:30879106
Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis. PMID:30877170
Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion-Driven Cancer. PMID:30877085
Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer. PMID:30875794
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy. PMID:30873179
A high-throughput screen identifies the long non-coding RNA DRAIC as a regulator of autophagy. PMID:30872794
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma. PMID:30872592
Examination of Independent Prognostic Power of Gene Expressions and Histopathological Imaging Features in Cancer. PMID:30871256
Multiomics Analysis Reveals that GLS and GLS2 Differentially Modulate the Clinical Outcomes of Cancer. PMID:30871151
Mutations in gliclazide-associated genes may predict poor bladder cancer prognosis. PMID:30868054
Resistance to lysosomotropic drugs used to treat kidney and breast cancers involves autophagy and inflammation and converges in inducing CXCL5. PMID:30867824
m6A RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance. PMID:30866959
Bioinformatic exploration of OLFML2B overexpression in gastric cancer base on multiple analyzing tools. PMID:30866865
GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells toward Breast Tumor Progression. PMID:30866584
FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer. PMID:30865895
Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cells. PMID:30863489
When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All? PMID:30863365
Polo-like kinase 3 is associated with poor prognosis and regulates proliferation and metastasis in prostate cancer. PMID:30863161
Significant prognostic values of aquaporin mRNA expression in breast cancer. PMID:30863160
Assessment of intra-tumoural colorectal cancer prognostic biomarkers using RNA in situ hybridisation. PMID:30858927
Gene regulation by antitumor miR-130b-5p in pancreatic ductal adenocarcinoma: the clinical significance of oncogenic EPS8. PMID:30858505
Computational analysis of the evolutionarily conserved Missing In Metastasis/Metastasis Suppressor 1 gene predicts novel interactions, regulatory regions and transcriptional control. PMID:30858428
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma. PMID:30858363
Enrichment of short mutant cell-free DNA fragments enhanced detection of pancreatic cancer. PMID:30857943
Prognostic and Clinicopathological Significance of SERTAD1 in Various Types of Cancer Risk: A Systematic Review and Retrospective Analysis. PMID:30857225
Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome. PMID:30856170
Overexpression of FZD1 is Associated with a Good Prognosis and Resistance of Sunitinib in Clear Cell Renal Cell Carcinoma. PMID:30854133
Mechanisms of MTH1 inhibition-induced DNA strand breaks: The slippery slope from the oxidized nucleotide pool to genotoxic damage. PMID:30852368
TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma. PMID:30850732
CC chemokines are differentially expressed in Breast Cancer and are associated with disparity in overall survival. PMID:30850664
TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers. PMID:30846808
Quantifying Tip60 (Kat5) stratifies breast cancer. PMID:30846725
PPARγ activation serves as therapeutic strategy against bladder cancer via inhibiting PI3K-Akt signaling pathway. PMID:30845932
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. PMID:30842661
Diverse tumour susceptibility in Collaborative Cross mice: identification of a new mouse model for human gastric tumourigenesis. PMID:30842212
A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. PMID:30840887
Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells. PMID:30839006
Alternative Splicing of MXD3 and Its Regulation of MXD3 Levels in Glioblastoma. PMID:30838212
DNA Ligase IV Prevents Replication Fork Stalling and Promotes Cellular Proliferation in Triple Negative Breast Cancer. PMID:30838131
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers. PMID:30833748
Paracrine Induction of Epithelial-Mesenchymal Transition Between Colorectal Cancer Cells and its Suppression by a p53/miR-192/215/NID1 Axis. PMID:30831320
GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation. PMID:30830860
Mutations in DNA repair genes are associated with increased neoantigen burden and a distinct immunophenotype in lung squamous cell carcinoma. PMID:30824826
The Novel Role of SOX2 as an Early Predictor of Cancer Risk in Patients with Laryngeal Precancerous Lesions. PMID:30823625
The Expression of the SLIT-ROBO Family in Adult Patients with Acute Myeloid Leukemia. PMID:30820596
ESR1 mutations in metastatic lobular breast cancer patients. PMID:30820448
Synergy from gene expression and network mining (SynGeNet) method predicts synergistic drug combinations for diverse melanoma genomic subtypes. PMID:30820351
POLE proofreading defects: Contributions to mutagenesis and cancer. PMID:30818169
Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of patients with head and neck cancer. PMID:30816478
Comprehensive sequencing of the myocilin gene in a selected cohort of severe primary open-angle glaucoma patients. PMID:30816137
Regulation of KIF2A by Antitumor miR-451a Inhibits Cancer Cell Aggressiveness Features in Lung Squamous Cell Carcinoma. PMID:30813343
Exome sequencing in 51 early onset non-familial CRC cases. PMID:30809968
VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness. PMID:30809300
Combined expression and prognostic significance of PPFIA1 and ALG3 in head and neck squamous cell carcinoma. PMID:30805892
Protocol Update for large-scale genome and gene function analysis with the PANTHER classification system (v.14.0). PMID:30804569
UBTD1 is a mechano-regulator controlling cancer aggressiveness. PMID:30804013
Novel genetic alterations and their impact on target therapy response in head and neck squamous cell carcinoma. PMID:30799957
The prognostic landscape of interactive biological processes presents treatment responses in cancer. PMID:30799199
The promising novel biomarkers and candidate small molecule drugs in kidney renal clear cell carcinoma: Evidence from bioinformatics analysis of high-throughput data. PMID:30793530
Differential effects, on oncogenic pathway signalling, by derivatives of the HNF4 α inhibitor BI6015. PMID:30792535
FBXW7 in Cancer: What Has Been Unraveled Thus Far? PMID:30791487
Dysregulation, functional implications, and prognostic ability of the circadian clock across cancers. PMID:30791227
Attenuated ZHX3 expression serves as a potential biomarker that predicts poor clinical outcomes in breast cancer patients. PMID:30787639
MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ breast cancer. PMID:30783203
Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential. PMID:30783010
Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities. PMID:30782821
Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. PMID:30782064
Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer. PMID:30781493
Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer. PMID:30777101
Prostate-specific loss of UXT promotes cancer progression. PMID:30774773
SETD2 loss sensitizes cells to PI3Kβ and AKT inhibition. PMID:30774762
LncRNA PCAT1 activates AKT and NF-κB signaling in castration-resistant prostate cancer by regulating the PHLPP/FKBP51/IKKα complex. PMID:30773595
ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. PMID:30773341
KLF5 and MYC modulated LINC00346 contributes to gastric cancer progression through acting as a competing endogeous RNA and indicates poor outcome. PMID:30770877
Overexpression of BUB1B, CCNA2, CDC20, and CDK1 in tumor tissues predicts poor survival in pancreatic ductal adenocarcinoma. PMID:30765611
Tailored NEOadjuvant epirubicin, cyclophosphamide and Nanoparticle Albumin-Bound paclitaxel for breast cancer: The phase II NEONAB trial-Clinical outcomes and molecular determinants of response. PMID:30763338
Molecular diagnosis of somatic overgrowth conditions: A single-center experience. PMID:30761771
Impact of the SPOP Mutant Subtype on the Interpretation of Clinical Parameters in Prostate Cancer. PMID:30761387
NRF2 Activation in Cancer: From DNA to Protein. PMID:30760522
SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination. PMID:30760284
Semaphorin 3C as a Therapeutic Target in Prostate and Other Cancers. PMID:30759745
Synergistic effects of SHP2 and PI3K pathway inhibitors in GAB2-overexpressing ovarian cancer. PMID:30755818
Ventricular-Subventricular Zone Contact by Glioblastoma is Not Associated with Molecular Signatures in Bulk Tumor Data. PMID:30755636
Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer. PMID:30755611
Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression. PMID:30755372
ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses. PMID:30754719
Variation in the repulsive guidance molecule family in human populations. PMID:30746893
Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration. PMID:30745454
Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1. PMID:30744692
Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E. PMID:30744688
Frequent Alteration of Annexin A9 and A10 in HPV-Negative Head and Neck Squamous Cell Carcinomas: Correlation with the Histopathological Differentiation Grade. PMID:30744186
SAMD5 mRNA was overexpressed in prostate cancer and can predict biochemical recurrence after radical prostatectomy. PMID:30739268
A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection. PMID:30737406
The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis. PMID:30737284
Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies. PMID:30737244
Pyruvate Kinase M2 serves as blockade for nucleosome repositioning and abrogates Chd7 remodeling activity. PMID:30735509
POLE-mutated clear cell cervical cancer associated with in-utero diethylstilbestrol exposure. PMID:30733993
Does functional specialization of ribosomes really exist? PMID:30733326
Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood. PMID:30733267
Functional characterization of a novel CSF1R mutation causing hereditary diffuse leukoencephalopathy with spheroids. PMID:30729751
Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells. PMID:30729097
Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer. PMID:30728399
IFN regulatory factor-8 expression in macrophages governs an antimetastatic program. PMID:30728331
Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer. PMID:30728081
The Expression Patterns of FAM83H and PANX2 Are Associated With Shorter Survival of Clear Cell Renal Cell Carcinoma Patients. PMID:30723706
A Guide to PIN1 Function and Mutations Across Cancers. PMID:30723410
Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer. PMID:30719498
High FOXM1 expression is a prognostic marker for poor clinical outcomes in prostate cancer. PMID:30719174
High Expression Levels of AGGF1 and MFAP4 Predict Primary Platinum-Based Chemoresistance and are Associated with Adverse Prognosis in Patients with Serous Ovarian Cancer. PMID:30719133
TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells. PMID:30718921
Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets. PMID:30718226
CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT/GSK-3β/β-catenin pathway. PMID:30717785
CENPE expression is associated with its DNA methylation status in esophageal adenocarcinoma and independently predicts unfavorable overall survival. PMID:30716092
Exploiting DNA repair defects in colorectal cancer. PMID:30714316
CD28H expression identifies resident memory CD8 + T cells with less cytotoxicity in human peripheral tissues and cancers. PMID:30713797
An actionable axis linking NFATc2 to EZH2 controls the EMT-like program of melanoma cells. PMID:30710146
Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer. PMID:30709841
Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients. PMID:30709382
Peripheral Circulating Tumor DNA Detection Predicts Poor Outcomes After Liver Resection for Metastatic Colorectal Cancer. PMID:30706231
ZEB1 Is a Transcription Factor That Is Prognostic and Predictive in Diffuse Gliomas. PMID:30705664
High-throughput RNAi screening reveals cancer-selective lethal targets in the RNA spliceosome. PMID:30705407
Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis. PMID:30705405
VICKZ1 enhances tumor progression and metastasis in lung adenocarcinomas in mice. PMID:30700831
Differentiating between cancer and normal tissue samples using multi-hit combinations of genetic mutations. PMID:30700767
Mutation Hotspots in the β-Catenin Gene: Lessons from the Human Cancer Genome Databases. PMID:30699286
Deficiency of mismatch repair genes is less frequently observed in signet ring cell compared with non-signet ring cell gastric cancer. PMID:30694393
Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression. PMID:30692636
The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis. PMID:30692632
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. PMID:30692626
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions. PMID:30692625
Data Lakes, Clouds, and Commons: A Review of Platforms for Analyzing and Sharing Genomic Data. PMID:30691868
Outcome and molecular characteristics of non-invasive encapsulated follicular variant of papillary thyroid carcinoma with oncocytic features. PMID:30689169
PKR: A Kinase to Remember. PMID:30686999
Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. PMID:30686591
PRDM16 functions as a suppressor of lung adenocarcinoma metastasis. PMID:30683132
Interaction of germline variants in a family with a history of early-onset clear cell renal cell carcinoma. PMID:30680959
Carbonic Anhydrase 6 Gene Variation influences Oral Microbiota Composition and Caries Risk in Swedish adolescents. PMID:30679524
Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment. PMID:30679171
3D Mammary Epithelial Cell Models: A Goldmine of DCIS Biomarkers and Morphogenetic Mechanisms. PMID:30678048
Utility of the JAX Clinical Knowledgebase in capture and assessment of complex genomic cancer data. PMID:30675517
Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico-pathological and molecular (next generation sequencing) study of 22 cases. PMID:30675285
Use case driven evaluation of open databases for pediatric cancer research. PMID:30675185
Testicular germ cell tumor: a comprehensive review. PMID:30671589
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme. PMID:30670691
Alternating Electric Fields (TTFields) Activate Cav1.2 Channels in Human Glioblastoma Cells. PMID:30669316
Liquid biopsy in central nervous system metastases: a RANO review and proposals for clinical applications. PMID:30668804
BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer. PMID:30667054
Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap. PMID:30664679
Development of a prognostic index based on an immunogenomic landscape analysis of papillary thyroid cancer. PMID:30661062
Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases. PMID:30659409
Deletion of C9orf53 promotes the growth of head and neck squamous cell carcinoma and is associated with poor prognosis of patients with head and neck squamous cell carcinoma. PMID:30655888
Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells. PMID:30654593
Molecular features of premenopausal breast cancers in Latin American women: Pilot results from the PRECAMA study. PMID:30653559
PANOPLY: Omics-Guided Drug Prioritization Method Tailored to an Individual Patient. PMID:30652605
D3Oncoprint: Stand-Alone Software to Visualize and Dynamically Explore Annotated Genomic Mutation Files. PMID:30652557
American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond-Lessons Learned and Member Institutions' Perspectives. PMID:30652542
Wild-type p53 regulates OTOP2 transcription through DNA loop alteration of the promoter in colorectal cancer. PMID:30652071
Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases. PMID:30651352
Impact of p85α Alterations in Cancer. PMID:30650664
Overcoming Intrinsic and Acquired Cetuximab Resistance in RAS Wild-Type Colorectal Cancer: An In Vitro Study on the Expression of HER Receptors and the Potential of Afatinib. PMID:30650638
p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value. PMID:30650356
Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer. PMID:30647855
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma. PMID:30647454
Nonmosaic somatic HIF2A mutations associated with late onset polycythemia-paraganglioma syndrome: Newly recognized subclass of polycythemia-paraganglioma syndrome. PMID:30644531
Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice. PMID:30644386
Robust analysis of novel mRNA-lncRNA cross talk based on ceRNA hypothesis uncovers carcinogenic mechanism and promotes diagnostic accuracy in esophageal cancer. PMID:30643460
ATDC mediates a TP63-regulated basal cancer invasive program. PMID:30643195
LUBAC determines chemotherapy resistance in squamous cell lung cancer. PMID:30642944
Epigenetic Mechanisms Influencing Epithelial to Mesenchymal Transition in Bladder Cancer. PMID:30642115
RCBTB1 Deletion Is Associated with Metastatic Outcome and Contributes to Docetaxel Resistance in Nontranslocation-Related Pleomorphic Sarcomas. PMID:30641971
SMAD4 alteration associates with invasive-front pathological markers and poor prognosis in colorectal cancer. PMID:30636020
Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy. PMID:30628708
Analysis across multiple tumor types provides no evidence that mutant p53 exerts dominant negative activity. PMID:30623031
Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma. PMID:30622339
Over-Expression of βII-Tubulin and Especially Its Localization in Cell Nuclei Correlates with Poorer Outcomes in Colorectal Cancer. PMID:30621030
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. PMID:30619488
Unbiased data mining identifies cell cycle transcripts that predict non-indolent Gleason score 7 prostate cancer. PMID:30616540
Integrated Analysis of Genetic Abnormalities of the Histone Lysine Methyltransferases in Prostate Cancer. PMID:30616239
Transcriptomic analyses identify key differentially expressed genes and clinical outcomes between triple-negative and non-triple-negative breast cancer. PMID:30613165
PepQuery enables fast, accurate, and convenient proteomic validation of novel genomic alterations. PMID:30610011
Next Generation-Targeted Amplicon Sequencing (NG-TAS): an optimised protocol and computational pipeline for cost-effective profiling of circulating tumour DNA. PMID:30609936
Cancer-testis antigens in ovarian cancer: implication for biomarkers and therapeutic targets. PMID:30609934
Alterations of the Immunologic Co-Stimulator B7 and TNFR Families Correlate with Hepatocellular Carcinoma Prognosis and Metastasis by Inactivating STAT3. PMID:30609841
IGFBP7 Drives Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition in Lung Cancer. PMID:30609749
CEP55 promotes epithelial-mesenchymal transition in renal cell carcinoma through PI3K/AKT/mTOR pathway. PMID:30607788
SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program. PMID:30606720
The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens. PMID:30606230
Exploring the differences between early-onset gastric cancer and traditional-onset gastric cancer. PMID:30603136
Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set. PMID:30602777
Chromatin regulatory mechanisms and therapeutic opportunities in cancer. PMID:30602726
Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem Cell and Proliferative Breast Cancer Cell Fates. PMID:30597041
Prognostic and clinicopathological value of FoxM1 expression in colorectal cancer: A systematic review and meta-analysis. PMID:30593202
Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis. PMID:30592710
Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer. PMID:30590044
ALKBH5 gene is a novel biomarker that predicts the prognosis of pancreatic cancer: A retrospective multicohort study. PMID:30588520
A comprehensive review of available omics data resources and molecular profiling for precision glioma studies. PMID:30588296
Distinct expression and prognostic value of members of the epidermal growth factor receptor family in ovarian cancer. PMID:30588099
An Analysis of the Expression and Association with Immune Cell Infiltration of the cGAS/STING Pathway in Pan-Cancer. PMID:30583098
Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer. PMID:30583079
Phosphatidylinositol 3-kinase pathway genomic alterations in 60,991 diverse solid tumors informs targeted therapy opportunities. PMID:30582752
A novel role for DGATs in cancer. PMID:30579761
Integrative Genomic Analyses Identifies GGA2 as a Cooperative Driver of EGFR-Mediated Lung Tumorigenesis. PMID:30578931
Gene expression analysis of heat-shock proteins and redox regulators reveals combinatorial prognostic markers in carcinomas of the gastrointestinal tract. PMID:30578123
The Role of DNA/Histone Modifying Enzymes and Chromatin Remodeling Complexes in Testicular Germ Cell Tumors. PMID:30577487
The downregulation of lncRNA EMX2OS might independently predict shorter recurrence-free survival of classical papillary thyroid cancer. PMID:30576338
Inter- and intra-tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas. PMID:30575147
Drug-target-disease network analysis of gene-phenotype connectivity for genistein in ovarian cancer. PMID:30573976
Impact of RAS mutation subtype on clinical outcome-a cross-entity comparison of patients with advanced non-small cell lung cancer and colorectal cancer. PMID:30568222
Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement. PMID:30568030
Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells. PMID:30559934
Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma. PMID:30558661
Germline BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance associated with breast/ovarian cancer: a report from North India. PMID:30555256
Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 signalling in head and neck squamous cell carcinoma. PMID:30555157
Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells. PMID:30552384
Mutational profiles of persistent/recurrent laryngeal squamous cell carcinoma. PMID:30548484
Upregulation of Long Non-Coding RNA DRAIC Correlates with Adverse Features of Breast Cancer. PMID:30544991
Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer. PMID:30544563
SMYD3 promotes the epithelial-mesenchymal transition in breast cancer. PMID:30544196
Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi is associated with cell cycle inhibition, apoptosis, DNA damage response and drug sensitivity in breast cancer. PMID:30543688
TP53 mutations as potential prognostic markers for specific cancers: analysis of data from The Cancer Genome Atlas and the International Agency for Research on Cancer TP53 Database. PMID:30542790
Long non-coding RNA LOC285194 functions as a tumor suppressor by targeting p53 in non-small cell lung cancer. PMID:30542733
PI3Kβ inhibitor AZD6482 exerts antiproliferative activity and induces apoptosis in human glioblastoma cells. PMID:30542720
Biomarkers for Programmed Death-1 Inhibition in Prostate Cancer. PMID:30541755
Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bio-orthogonally Conjugated Drug. PMID:30540482
Update of Pheochromocytoma Syndromes: Genetics, Biochemical Evaluation, and Imaging. PMID:30538672
Integrated analysis reveals key genes with prognostic value in lung adenocarcinoma. PMID:30538558
TET2-Dependent Hydroxymethylome Plasticity Reduces Melanoma Initiation and Progression. PMID:30538121
Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment. PMID:30538091
CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development. PMID:30531840
Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling. PMID:30530503
Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models. PMID:30526553
Adipocytes and Obesity-Related Conditions Jointly Promote Breast Cancer Cell Growth and Motility: Associations With CAP1 for Prognosis. PMID:30524378
The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland. PMID:30520817
DNA translocation mechanism of an XPD family helicase. PMID:30520735
Comprehensive Analysis of BAP1 Somatic Mutation in Clear Cell Renal Cell Carcinoma to Explore Potential Mechanisms in Silico. PMID:30519310
m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression. PMID:30518868
CD4+ T cells induce rejection of urothelial tumors after immune checkpoint blockade. PMID:30518683
A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. PMID:30518210
Distinctive Expression and Amplification of Genes at 11q13 in Relation to HPV Status with Impact on Survival in Head and Neck Cancer Patients. PMID:30513772
Loss of function, missense, and intronic variants in NOTCH1 confer different risks for left ventricular outflow tract obstructive heart defects in two European cohorts. PMID:30511478
Cyclin E1 and Rb modulation as common events at time of resistance to palbociclib in hormone receptor-positive breast cancer. PMID:30511015
Deletion of 3p13 is a late event linked to progression of TMPRSS2:ERG fusion prostate cancer. PMID:30510458
MSIpred: a python package for tumor microsatellite instability classification from tumor mutation annotation data using a support vector machine. PMID:30510242
GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment. PMID:30509602
Isocitrate dehydrogenase gene mutations and 2-hydroxyglutarate accumulation in esophageal squamous cell carcinoma. PMID:30506321
Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling. PMID:30504771
Financially effective test algorithm to identify an aggressive, EGFR-amplified variant of IDH-wildtype, lower-grade diffuse glioma. PMID:30496526
CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. PMID:30487607
Overexpression of MUC1 predicts poor prognosis in patients with breast cancer. PMID:30483806
Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations. PMID:30482722
The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. PMID:30480076
Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells. PMID:30475204
Targets and genomic constraints of ectopic Dnmt3b expression. PMID:30468428
Different behaviour of DVL1, DVL2, DVL3 in astrocytoma malignancy grades and their association to TCF1 and LEF1 upregulation. PMID:30468298
EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer. PMID:30463996
Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells. PMID:30463939
New Insights into the Runt Domain of RUNX2 in Melanoma Cell Proliferation and Migration. PMID:30463392
Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis. PMID:30460631
The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis. PMID:30460237
TEAD4 overexpression promotes epithelial-mesenchymal transition and associates with aggressiveness and adverse prognosis in head neck squamous cell carcinoma. PMID:30459528
A comparative analysis of KMT2D missense variants in Kabuki syndrome, cancers and the general population. PMID:30459467
Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment. PMID:30458886
Machine Learning With K-Means Dimensional Reduction for Predicting Survival Outcomes in Patients With Breast Cancer. PMID:30455569
Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. PMID:30454645
Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations. PMID:30449325
KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer. PMID:30448242
Targeted sequencing of plasmacytoid urothelial carcinoma reveals frequent TERT promoter mutations. PMID:30447301
HHLA2 is a novel immune checkpoint protein in pancreatic ductal adenocarcinoma and predicts post-surgical survival. PMID:30447255
RET rearrangements are actionable alterations in breast cancer. PMID:30446652
Induction of MNK Kinase-dependent eIF4E Phosphorylation by Inhibitors Targeting BET Proteins Limits Efficacy of BET Inhibitors. PMID:30446586
Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma. PMID:30445726
15 years of PhosphoSitePlus®: integrating post-translationally modified sites, disease variants and isoforms. PMID:30445427
The transcriptional coactivator WBP2 primes triple-negative breast cancer cells for responses to Wnt signaling via the JNK/Jun kinase pathway. PMID:30442712
Advances in HER2-Targeted Therapy: Novel Agents and Opportunities Beyond Breast and Gastric Cancer. PMID:30442682
Immunogenomic Landscape Contributes to Hyperprogressive Disease after Anti-PD-1 Immunotherapy for Cancer. PMID:30439581
Restoration of FBP1 suppressed Snail-induced epithelial to mesenchymal transition in hepatocellular carcinoma. PMID:30429463
The Emerging Role of Epitranscriptomics in Cancer: Focus on Urological Tumors. PMID:30428628
Downregulation of IQGAP2 Correlates with Prostate Cancer Recurrence and Metastasis. PMID:30428404
TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. PMID:30428345
Regional differences in gallbladder cancer pathogenesis: Insights from a multi-institutional comparison of tumor mutations. PMID:30427539
MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers. PMID:30425131
Cell Origins of High-Grade Serous Ovarian Cancer. PMID:30424539
Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13. PMID:30422115
Whole exome sequencing identifies recessive germline mutations in FAM160A1 in familial NK/T cell lymphoma. PMID:30420729
SETD2 mutations in primary central nervous system tumors. PMID:30419952
Association of specific gene mutations derived from machine learning with survival in lung adenocarcinoma. PMID:30419062
Multi-faceted computational assessment of risk and progression in oligodendroglioma implicates NOTCH and PI3K pathways. PMID:30417117
The extrema of circulating miR-17 are identified as biomarkers for aggressive prostate cancer. PMID:30416858
A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer. PMID:30414698
The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance. PMID:30413706
Over expression of DNA damage and cell cycle dependent proteins are associated with poor survival in patients with adrenocortical carcinoma. PMID:30413320
Development of a Novel Autophagy-related Prognostic Signature for Serous Ovarian Cancer. PMID:30410611
CDK5 Functions as a Tumor Promoter in Human Lung Cancer. PMID:30410599
Cancer3D 2.0: interactive analysis of 3D patterns of cancer mutations in cancer subsets. PMID:30407596
Genomic Network-Based Analysis Reveals Pancreatic Adenocarcinoma Up-Regulating Factor-Related Prognostic Markers in Cervical Carcinoma. PMID:30406031
CDK9 Expression Shows Role as a Potential Prognostic Biomarker in Breast Cancer Patients Who Fail to Achieve Pathologic Complete Response after Neoadjuvant Chemotherapy. PMID:30405916
The anti-psychotic drug pimozide is a novel chemotherapeutic for breast cancer. PMID:30405882
Emerging Roles of Fibroblast Growth Factor 10 in Cancer. PMID:30405704
Polyamine synthesis as a target of MYC oncogenes. PMID:30404920
Managing Clonal Hematopoiesis in Patients With Solid Tumors. PMID:30403571
Onco-Multi-OMICS Approach: A New Frontier in Cancer Research. PMID:30402498
HOPX homeobox methylation in differentiated thyroid cancer and its clinical relevance. PMID:30400039
Cell Surface Notch Ligand DLL3 is a Therapeutic Target in Isocitrate Dehydrogenase-mutant Glioma. PMID:30397180
Metastasis Suppressor NME1 Directly Activates Transcription of the ALDOC Gene in Melanoma Cells. PMID:30396920
Tumor stroma-infiltrating mast cells predict prognosis and adjuvant chemotherapeutic benefits in patients with muscle invasive bladder cancer. PMID:30393586
Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer. PMID:30393068
Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma. PMID:30389701
Hydroxysteroid 11-Beta Dehydrogenase 1 Overexpression with Copy-Number Gain and Missense Mutations in Primary Gastrointestinal Stromal Tumors. PMID:30388854
KDM5A Regulates a Translational Program that Controls p53 Protein Expression. PMID:30388705
IL-21R functions as an oncogenic factor and is regulated by the lncRNA MALAT1/miR-125a-3p axis in gastric cancer. PMID:30387833
Tumor mutational burden is a determinant of immune-mediated survival in breast cancer. PMID:30386679
Recovery of T-cell receptor V(D)J recombination reads from lower grade glioma exome files correlates with reduced survival and advanced cancer grade. PMID:30382482
Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus. PMID:30373810
Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients to Targeted and Immune Therapies. PMID:30373752
SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics. PMID:30373609
Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth. PMID:30367629
Single-cell RNA-seq analysis reveals the platinum resistance gene COX7B and the surrogate marker CD63. PMID:30367559
Bclaf1 promotes angiogenesis by regulating HIF-1α transcription in hepatocellular carcinoma. PMID:30367150
Examination of the expression and prognostic significance of DLGAPs in gastric cancer using the TCGA database and bioinformatic analysis. PMID:30365066
Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells. PMID:30364132
Upregulation of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in Tumor Tissues Predicted Worse Overall Survival and Disease-Free Survival in Hepatocellular Carcinoma Patients. PMID:30363964
FBXO17 promotes cell proliferation through activation of Akt in lung adenocarcinoma cells. PMID:30359271
Molecular classification and subtype-specific drug sensitivity research of uterine carcinosarcoma under multi-omics framework. PMID:30359167
Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue. PMID:30357923
PTPN11 Plays Oncogenic Roles and Is a Therapeutic Target for BRAF Wild-Type Melanomas. PMID:30355677
Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast Cancer. PMID:30355675
Deregulation of MicroRNA-375 Inhibits Proliferation and Migration in Gastric Cancer in Association With Autophagy-Mediated AKT/mTOR Signaling Pathways. PMID:30355273
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer. PMID:30353166
SAC3D1: a novel prognostic marker in hepatocellular carcinoma. PMID:30353105
DNA Methylation Predicts the Response of Triple-Negative Breast Cancers to All-Trans Retinoic Acid. PMID:30352973
DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway. PMID:30352910
Somatic mutations in renal cell carcinomas from Chinese patients revealed by whole exome sequencing. PMID:30349421
Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer. PMID:30349298
Ribosome biogenesis factor Ltv1 chaperones the assembly of the small subunit head. PMID:30348748
Identification of SUV39H2 as a potential oncogene in lung adenocarcinoma. PMID:30348215
Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress. PMID:30347795
Therapeutic potential of targeting the Eph/ephrin signaling complex. PMID:30343150
Maftools: efficient and comprehensive analysis of somatic variants in cancer. PMID:30341162
H19 regulation of oestrogen induction of symmetric division is achieved by antagonizing Let-7c in breast cancer stem-like cells. PMID:30338598
The HER3 pathway as a potential target for inhibition in patients with biliary tract cancers. PMID:30335866
Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene. PMID:30333512
Genetic and Epigenetic Determinants of Aggressiveness in Cribriform Carcinoma of the Prostate. PMID:30333152
Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response. PMID:30332631
BGJ398, A Pan-FGFR Inhibitor, Overcomes Paclitaxel Resistance in Urothelial Carcinoma with FGFR1 Overexpression. PMID:30326563
CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. PMID:30325015
Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN-FOS at composite DNA sites. PMID:30315111
Identification of WDR12 as a novel oncogene involved in hepatocellular carcinoma propagation. PMID:30310320
Integrative analysis of transcriptomics and clinical data uncovers the tumor-suppressive activity of MITF in prostate cancer. PMID:30310055
Clinical Impact of Tumor Mutational Burden in Neuroblastoma. PMID:30307503
Afatinib treatment for her-2 amplified metastatic colorectal cancer based on patient-derived xenograft models and next generation sequencing. PMID:30307354
Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas. PMID:30306125
Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia. PMID:30305637
Molecular profiling of hormone receptor-positive, HER2-negative breast cancers from patients treated with neoadjuvant endocrine therapy in the CARMINA 02 trial (UCBG-0609). PMID:30305115
Genomic analysis of DNA repair genes and androgen signaling in prostate cancer. PMID:30305041
Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells. PMID:30297743
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells. PMID:30293938
Heterozygous loss-of-function variants of MEIS2 cause a triad of palatal defects, congenital heart defects, and intellectual disability. PMID:30291340
Genomic Differences Between "Primary" and "Secondary" Muscle-invasive Bladder Cancer as a Basis for Disparate Outcomes to Cisplatin-based Neoadjuvant Chemotherapy. PMID:30290956
Identification of Key Genes and Pathways Associated with RUNX1 Mutations in Acute Myeloid Leukemia Using Bioinformatics Analysis. PMID:30289875
Transduced caudal-type homeobox (CDX) 2/CDX1 can induce growth inhibition on CDX-deficient gastric cancer by rapid intestinal differentiation. PMID:30289576
Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy. PMID:30289335
The comprehensive molecular landscape of the immunologic co-stimulator B7 and TNFR ligand receptor families in colorectal cancer: immunotherapeutic implications with microsatellite instability. PMID:30288357
Mutation pattern analysis reveals polygenic mini-drivers associated with relapse after surgery in lung adenocarcinoma. PMID:30287876
Systematic expression alteration analysis of master reprogramming factor OCT4 and its three pseudogenes in human cancer and their prognostic outcomes. PMID:30287838
Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers. PMID:30287808
Genomics of drug sensitivity in bladder cancer: an integrated resource for pharmacogenomic analysis in bladder cancer. PMID:30285760
Tumor-Intrinsic PD-L1 Signaling in Cancer Initiation, Development and Treatment: Beyond Immune Evasion. PMID:30283733
Tumor-preventing activity of aspirin in multiple cancers based on bioinformatic analyses. PMID:30280037
Gap Junction Intercellular Communication Positively Regulates Cisplatin Toxicity by Inducing DNA Damage through Bystander Signaling. PMID:30279363
Increased EXT1 gene copy number correlates with increased mRNA level predicts short disease-free survival in hepatocellular carcinoma without vascular invasion. PMID:30278583
Quantitative phosphoproteomic analysis identifies novel functional pathways of tumor suppressor DLC1 in estrogen receptor positive breast cancer. PMID:30278072
Application of weighted gene co-expression network analysis to identify key modules and hub genes in oral squamous cell carcinoma tumorigenesis. PMID:30275705
High Expression of EpCAM and Sox2 is a Positive Prognosticator of Clinical Outcome for Head and Neck Carcinoma. PMID:30275505
Molecular Lesions of Insulator CTCF and Its Paralogue CTCFL (BORIS) in Cancer: An Analysis from Published Genomic Studies. PMID:30275357
TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis. PMID:30274972
Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma. PMID:30272346
Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5. PMID:30271790
Expressions and prognostic values of the E2F transcription factors in human breast carcinoma. PMID:30271201
ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer. PMID:30270106
MiPanda: A Resource for Analyzing and Visualizing Next-Generation Sequencing Transcriptomics Data. PMID:30268942
A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily. PMID:30268436
Host IDO2 Gene Status Influences Tumor Progression and Radiotherapy Response in KRAS-Driven Sporadic Pancreatic Cancers. PMID:30266763
ZBTB7A governs estrogen receptor alpha expression in breast cancer. PMID:30265334
Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase. PMID:30261690
Cell Model Passports-a hub for clinical, genetic and functional datasets of preclinical cancer models. PMID:30260411
A prognostic mRNA expression signature of four 16q24.3 genes in radio(chemo)therapy-treated head and neck squamous cell carcinoma (HNSCC). PMID:30259648
CDKN2A as transcriptomic marker for muscle-invasive bladder cancer risk stratification and therapy decision-making. PMID:30258198
A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes. PMID:30258054
Min-redundancy and max-relevance multi-view feature selection for predicting ovarian cancer survival using multi-omics data. PMID:30255801
Association of Pioglitazone with Increased Risk of Prostate Cancer and Pancreatic Cancer: A Functional Network Study. PMID:30255424
Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity. PMID:30254278
Targeting kinases with precision. PMID:30250891
Differential expressions of integrin-linked kinase, β-parvin and cofilin 1 in high-fat diet induced prostate cancer progression in a transgenic mouse model. PMID:30250560
Landscape of somatic mutations in gastric cancer assessed using next-generation sequencing analysis. PMID:30250552
Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis. PMID:30250075
Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants. PMID:30249606
Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments. PMID:30244836
Does Axl have potential as a therapeutic target in pancreatic cancer? PMID:30244621
SMC1A is associated with radioresistance in prostate cancer and acts by regulating epithelial-mesenchymal transition and cancer stem-like properties. PMID:30242889
Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma. PMID:30242167
The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model. PMID:30241549
Circulating Nucleic Acids Are Associated With Outcomes of Patients With Pancreatic Cancer. PMID:30240661
Lack of APC somatic mutation is associated with early-onset colorectal cancer in African Americans. PMID:30239619
A miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis controls testicular germ cell tumor growth. PMID:30237497
The endothelial glycocalyx anchors von Willebrand factor fibers to the vascular endothelium. PMID:30237293
Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas. PMID:30236127
Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression. PMID:30228209
Early Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma. PMID:30227407
Targeting LRP8 inhibits breast cancer stem cells in triple-negative breast cancer. PMID:30227220
ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner. PMID:30226859
KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer. PMID:30226594
Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular stress. PMID:30224719
TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM. PMID:30221069
Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer. PMID:30220976
A pan-cancer atlas of cancer hallmark-associated candidate driver lncRNAs. PMID:30216655
Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival. PMID:30214626
A TOP2A-derived cancer panel drives cancer progression in papillary renal cell carcinoma. PMID:30214555
Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids. PMID:30213835
Genomics of adult and pediatric solid tumors. PMID:30210910
Multifaceted regulation and functions of replication factor C family in human cancers. PMID:30210909
Integrative Histologic and Bioinformatics Analysis of BIRC5/Survivin Expression in Oral Squamous Cell Carcinoma. PMID:30205554
Prognostic modeling of the immune-centric transcriptome reveals interleukin signaling candidates contributing to differential patient outcomes. PMID:30202894
BAP1 links metabolic regulation of ferroptosis to tumour suppression. PMID:30202049
PTPRT and PTPRD Deleterious Mutations and Deletion Predict Bevacizumab Resistance in Metastatic Colorectal Cancer Patients. PMID:30200630
The p53 Pathway in Glioblastoma. PMID:30200436
ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer. PMID:30200227
P4HA3 is Epigenetically Activated by Slug in Gastric Cancer and its Deregulation is Associated With Enhanced Metastasis and Poor Survival. PMID:30198421
HLBS-PopOmics: an online knowledge base to accelerate dissemination and implementation of research advances in population genomics to reduce the burden of heart, lung, blood, and sleep disorders. PMID:30197419
POLE gene hotspot mutations in advanced pancreatic cancer. PMID:30194485
Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer. PMID:30194340
NRAS mutant melanoma: an overview for the clinician for melanoma management. PMID:30190872
Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells. PMID:30190481
The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer. PMID:30188895
Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis. PMID:30188888
Signaling by discoidin domain receptor 1 in cancer metastasis. PMID:30187813
Expression profiling of ubiquitin-related genes in LKB1 mutant lung adenocarcinoma. PMID:30185829
Characterization of Mutations in the Mitochondrial Encoded Electron Transport Chain Complexes in Acute Myeloid Leukemia. PMID:30185817
Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. PMID:30185663
Structural insights into the functional diversity of the CDK-cyclin family. PMID:30185601
Precision Lasso: accounting for correlations and linear dependencies in high-dimensional genomic data. PMID:30184048
Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer. PMID:30181917
Identification of key pathways and genes in response to trastuzumab treatment in breast cancer using bioinformatics analysis. PMID:30181805
GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression. PMID:30181547
Synergistic Interaction of HOXB13 and CIP2A Predisposes to Aggressive Prostate Cancer. PMID:30181389
Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner. PMID:30177832
Genomic case report of a low grade bladder tumor metastasis to lung. PMID:30176882
Mutations, Differential Gene Expression, and Chimeric Transcripts in Esophageal Squamous Cell Carcinoma Show High Heterogeneity. PMID:30172240
Prevalence of DNA repair gene mutations in localized prostate cancer according to clinical and pathologic features: association of Gleason score and tumor stage. PMID:30171229
Rare but Recurrent ROS1 Fusions Resulting From Chromosome 6q22 Microdeletions are Targetable Oncogenes in Glioma. PMID:30171048
Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT). PMID:30170559
Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling. PMID:30169771
DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity. PMID:30167090
A feed forward loop enforces YAP/TAZ signaling during tumorigenesis. PMID:30158528
ANO7 is associated with aggressive prostate cancer. PMID:30157291
BRAF and AXL oncogenes drive RIPK3 expression loss in cancer. PMID:30157175
IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization. PMID:30154549
PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer. PMID:30154144
HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma. PMID:30153855
Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia. PMID:30150773
Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors. PMID:30150660
Revisiting the Clinical and Biologic Relevance of Partial PTEN Loss in Melanoma. PMID:30148988
Current Landscape of Targeted Therapies for Hormone-Receptor Positive, HER2 Negative Metastatic Breast Cancer. PMID:30148117
How does inflammation drive mutagenesis in colorectal cancer? PMID:30147278
Regulation and modulation of PTEN activity. PMID:30145641
ARID1A-deficiency in urothelial bladder cancer: No predictive biomarker for EZH2-inhibitor treatment response? PMID:30138427
Recent advances in prostate cancer research: large-scale genomic analyses reveal novel driver mutations and DNA repair defects. PMID:30135717
Activin receptor-like kinase 1 is associated with immune cell infiltration and regulates CLEC14A transcription in cancer. PMID:30132150
BCMA (TNFRSF17) Induces APRIL and BAFF Mediated Breast Cancer Cell Stemness. PMID:30131941
Increased HSF1 expression predicts shorter disease-specific survival of prostate cancer patients following radical prostatectomy. PMID:30131848
Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer. PMID:30128035
The knockdown of the Mediator complex subunit MED15 restrains urothelial bladder cancer cells' malignancy. PMID:30127891
Skp2 expression has different clinicopathological and prognostic implications in lung adenocarcinoma and squamous cell carcinoma. PMID:30127874
Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation. PMID:30127433
Metastatic cells are preferentially vulnerable to lysosomal inhibition. PMID:30127018
p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2. PMID:30126895
Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance. PMID:30126203
Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma. PMID:30125264
Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer. PMID:30123134
Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA. PMID:30121369
A Novel Approach for Identifying Relevant Genes for Breast Cancer Survivability on Specific Therapies. PMID:30116102
Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer. PMID:30115973
Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells. PMID:30112110
Mouse models in the era of large human tumour sequencing studies. PMID:30111589
Novel clinicopathological and molecular characterization of metanephric adenoma: a study of 28 cases. PMID:30111351
A New Strategy to Uncover the Anticancer Mechanism of Chinese Compound Formula by Integrating Systems Pharmacology and Bioinformatics. PMID:30108661
Identification of an oncogenic network with prognostic and therapeutic value in prostate cancer. PMID:30108134
Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes. PMID:30107825
Increased levels of RECQ5 shift DNA repair from canonical to alternative pathways. PMID:30107528
Endogenous HIF2A reporter systems for high-throughput functional screening. PMID:30104738
The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor. PMID:30104711
A pan-cancer study of the transcriptional regulation of uricogenesis in human tumours: pathological and pharmacological correlates. PMID:30104401
Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors. PMID:30101194
A novel mechanism of SRRM4 in promoting neuroendocrine prostate cancer development via a pluripotency gene network. PMID:30100395
Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis. PMID:30099850
Machine learning and feature selection for drug response prediction in precision oncology applications. PMID:30097794
Identification of UAP1L1 as a critical factor for protein O-GlcNAcylation and cell proliferation in human hepatoma cells. PMID:30097606
CEP55 Promotes Cell Motility via JAK2⁻STAT3⁻MMPs Cascade in Hepatocellular Carcinoma. PMID:30096813
Downregulation of CEACAM6 gene expression in laryngeal squamous cell carcinoma is an effect of DNA hypermethylation and correlates with disease progression. PMID:30094098
Positive crosstalk between EGFR and the TF-PAR2 pathway mediates resistance to cisplatin and poor survival in cervical cancer. PMID:30093972
Transcriptomic analysis of CIC and ATXN1L reveal a functional relationship exploited by cancer. PMID:30093628
Survival in males with glioma and gastric adenocarcinoma correlates with mutant p53 residual transcriptional activity. PMID:30089713
The Cancer Omics Atlas: an integrative resource for cancer omics annotations. PMID:30089500
Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients. PMID:30088263
Mutations in NOTCH1 and nucleotide excision repair genes are correlated with prognosis of hepatitis B virus-associated hepatocellular carcinoma. PMID:30087708
Essential role of MED1 in the transcriptional regulation of ER-dependent oncogenic miRNAs in breast cancer. PMID:30087366
Integrative analysis of the inter-tumoral heterogeneity of triple-negative breast cancer. PMID:30087365
Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer. PMID:30086764
Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer. PMID:30078843
RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers. PMID:30078441
Sno-derived RNAs are prevalent molecular markers of cancer immunity. PMID:30072739
A Targeted Quantitative Proteomic Approach Assesses the Reprogramming of Small GTPases during Melanoma Metastasis. PMID:30072397
Exploring the OncoGenomic Landscape of cancer. PMID:30071882
Role of Pseudogenes in Tumorigenesis. PMID:30071685
TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727. PMID:30065235
ER stress-related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer. PMID:30063110
Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study. PMID:30062862
Enabling Precision Cardiology Through Multiscale Biology and Systems Medicine. PMID:30062151
Central role of autophagic UVRAG in melanogenesis and the suntan response. PMID:30061422
Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). PMID:30061297
CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest. PMID:30061045
Targeted Next-Generation Sequencing Identifies Actionable Targets in Estrogen Receptor Positive and Estrogen Receptor Negative Endometriod Endometrial Cancer. PMID:30057548
BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery. PMID:30053270
TC3A: The Cancer 3' UTR Atlas. PMID:30053266
Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. PMID:30053102
Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing. PMID:30052636
Co-inhibition of mTORC1, HDAC and ESR1α retards the growth of triple-negative breast cancer and suppresses cancer stem cells. PMID:30050079
The mutational landscape of recurrent versus nonrecurrent human papillomavirus-related oropharyngeal cancer. PMID:30046007
The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma. PMID:30046005
CIGene: a literature-based online resource for cancer initiation genes. PMID:30045691
Upregulation of PD-L1 predicts poor prognosis and is associated with miR-191-5p dysregulation in colon adenocarcinoma. PMID:30045644
Nuclear receptor ERRα and transcription factor ERG form a reciprocal loop in the regulation of TMPRSS2:ERG fusion gene in prostate cancer. PMID:30042415
HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer. PMID:30042341
Regulation of the oncogenic phenotype by the nuclear body protein ZC3H8. PMID:30041613
CAD/POLD2 gene expression is associated with poor overall survival and chemoresistance in bladder urothelial carcinoma. PMID:30038717
CDK4/6 inhibition in breast cancer: current practice and future directions. PMID:30038670
Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation. PMID:30037981
Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer. PMID:30037904
RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer. PMID:30037330
Computational Approaches to Prioritize Cancer Driver Missense Mutations. PMID:30037003
Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus. PMID:30033361
Construction of a set of novel and robust gene expression signatures predicting prostate cancer recurrence. PMID:30024105
A Review of FOXI3 Regulation of Development and Possible Roles in Cancer Progression and Metastasis. PMID:30018953
Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes. PMID:30018742
A multiomics analysis of S100 protein family in breast cancer. PMID:30018736
Oral inflammation promotes oral squamous cell carcinoma invasion. PMID:30018735
Integrated genetic and epigenetic analysis of myxofibrosarcoma. PMID:30018380
Machine Learning for Better Prognostic Stratification and Driver Gene Identification Using Somatic Copy Number Variations in Anaplastic Oligodendroglioma. PMID:30018130
Elucidating feed-forward apoptosis signatures in breast cancer datasets: Higher FOS expression associated with a better outcome. PMID:30013671
TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins. PMID:30013069
In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer. PMID:30013058
CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade. PMID:30012853
Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss? PMID:30009155
Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. PMID:30007416
Exosomal zinc transporter ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer. PMID:30007115
Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations. PMID:30006355
Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton. PMID:30005669
An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression. PMID:30004690
You won't believe this old test … that does cheap single-cell mutation detection. PMID:30003713
Identification and validation of SRY-box containing gene family member SOX30 methylation as a prognostic and predictive biomarker in myeloid malignancies. PMID:30002740
Tumor Suppressor Activity of Selenbp1, a Direct Nkx2-1 Target, in Lung Adenocarcinoma. PMID:30002193
Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers. PMID:29997511
KM-express: an integrated online patient survival and gene expression analysis tool for the identification and functional characterization of prognostic markers in breast and prostate cancers. PMID:29992322
FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium. PMID:29991799
Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers. PMID:29991691
LINC00152 Promotes Invasion through a 3'-Hairpin Structure and Associates with Prognosis in Glioblastoma. PMID:29991527
Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development. PMID:29990498
Nuclear factor-κB p65 regulates glutaminase 1 expression in human hepatocellular carcinoma. PMID:29988727
Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy. PMID:29988316
Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance. PMID:29987135
Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates. PMID:29985390
Tongue carcinoma in young adults: a review of the literature. PMID:29984792
Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance. PMID:29983888
Prostate cancer susceptibility gene HIST1H1A is a modulator of androgen receptor signaling and epithelial to mesenchymal transition. PMID:29983878
Long non-coding RNAs: implications in targeted diagnoses, prognosis, and improved therapeutic strategies in human non- and triple-negative breast cancer. PMID:29983835
Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model. PMID:29981811
GABA promotes gastrin-releasing peptide secretion in NE/NE-like cells: Contribution to prostate cancer progression. PMID:29980692
Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells. PMID:29980625
PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition. PMID:29975751
Eosinophilic Solid and Cystic (ESC) Renal Cell Carcinomas Harbor TSC Mutations: Molecular Analysis Supports an Expanding Clinicopathologic Spectrum. PMID:29975249
Subependymal giant cell astrocytoma-like astrocytoma: a neoplasm with a distinct phenotype and frequent neurofibromatosis type-1-association. PMID:29973652
Aberrant Promoter Methylation of YAP Gene and its Subsequent Downregulation in Indian Breast Cancer Patients. PMID:29970036
Oncogenic c-terminal cyclin D1 (CCND1) mutations are enriched in endometrioid endometrial adenocarcinomas. PMID:29969496
Regulation of antitumor miR-144-5p targets oncogenes: Direct regulation of syndecan-3 and its clinical significance. PMID:29968393
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia. PMID:29967349
Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis. PMID:29967250
Activating HER3 mutations in breast cancer. PMID:29963236
Identification of an enhancer region within the TP63/LEPREL1 locus containing genetic variants associated with bladder cancer risk. PMID:29956121
EGFR activation induced Snail-dependent EMT and myc-dependent PD-L1 in human salivary adenoid cystic carcinoma cells. PMID:29954240
MiR-146a promotes the asymmetric division and inhibits the self-renewal ability of breast cancer stem-like cells via indirect upregulation of Let-7. PMID:29954239
RUMI is a novel negative prognostic marker and therapeutic target in non-small-cell lung cancer. PMID:29953591
Biomarker discovery by integrated joint non-negative matrix factorization and pathway signature analyses. PMID:29950679
Long Noncoding RNAs in Colorectal Adenocarcinoma; an in silico Analysis. PMID:29948619
The Role of Fibrinogen-Like Protein 2 on Immunosuppression and Malignant Progression in Glioma. PMID:29947810
MuvB: A Key to Cell Cycle Control in Ovarian Cancer. PMID:29942794
LncRNA ITGB2-AS1 Could Promote the Migration and Invasion of Breast Cancer Cells through Up-Regulating ITGB2. PMID:29941860
O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1. PMID:29941490
Parkinson's disease-associated protein Parkin: an unusual player in cancer. PMID:29941042
Gene expression profile and cancer-associated pathways linked to progesterone receptor isoform a (PRA) predominance in transgenic mouse mammary glands. PMID:29940887
Role of RNF20 in cancer development and progression - a comprehensive review. PMID:29934362
Connexin 43 C-terminus directly inhibits the hyperphosphorylation of Akt/ERK through protein-protein interactions in glioblastoma. PMID:29931708
Potential candidate treatment agents for targeting of cholangiocarcinoma identified by gene expression profile analysis. PMID:29930804
Frequent epigenetic alterations in polycomb repressive complex 2 in osteosarcoma cell lines. PMID:29930752
Anti-tumor roles of both strands of the miR-455 duplex: their targets SKA1 and SKA3 are involved in the pathogenesis of renal cell carcinoma. PMID:29928475
Novel insights into biomarkers associated with renal cell carcinoma. PMID:29928389
Upregulation of the EMT marker vimentin is associated with poor clinical outcome in acute myeloid leukemia. PMID:29925392
Molecular Characterization and Putative Pathogenic Pathways of Tuberous Sclerosis Complex-Associated Renal Cell Carcinoma. PMID:29925043
viGEN: An Open Source Pipeline for the Detection and Quantification of Viral RNA in Human Tumors. PMID:29922260
Daxx Functions Are p53-Independent In Vivo. PMID:29903771
Low expression of KCNN3 may affect drug resistance in ovarian cancer. PMID:29901154
Dataset describing the development, optimization and application of SRM/MRM based targeted proteomics strategy for quantification of potential biomarkers of EGFR TKI sensitivity. PMID:29900338
The immune checkpoint protein PD-L1 induces and maintains regulatory T cells in glioblastoma. PMID:29900065
Complex pattern of immune evasion in MSI colorectal cancer. PMID:29900056
High Densities of Tumor-Associated Plasma Cells Predict Improved Prognosis in Triple Negative Breast Cancer. PMID:29899747
NDRG1 regulates neutral lipid metabolism in breast cancer cells. PMID:29898756
A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor. PMID:29892571
Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer. PMID:29892061
Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis. PMID:29891536
Analysis of differentially expressed genes, clinical value and biological pathways in prostate cancer. PMID:29887958
Precision Medicine in Head and Neck Cancer: Myth or Reality? PMID:29887732
The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck. PMID:29884408
CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation. PMID:29884215
Expression and prognostic value of cell-cycle-associated genes in gastric adenocarcinoma. PMID:29884122
Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies. PMID:29880484
Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways. PMID:29875996
Turning Uridines around: Role of rRNA Pseudouridylation in Ribosome Biogenesis and Ribosomal Function. PMID:29874862
RECK isoforms have opposing effects on cell migration. PMID:29874120
Elevated expression of podoplanin and its clinicopathological, prognostic, and therapeutic values in squamous non-small cell lung cancer. PMID:29872344
Agrin has a pathological role in the progression of oral cancer. PMID:29872149
Transcriptomic analysis and mutational status of IDH1 in paired primary-recurrent intrahepatic cholangiocarcinoma. PMID:29871612
Hijacking a key chromatin modulator creates epigenetic vulnerability for MYC-driven cancer. PMID:29870403
RNA-Seq of Circulating Tumor Cells in Stage II-III Breast Cancer. PMID:29868978
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer. PMID:29867227
Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway. PMID:29866109
ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D. PMID:29863497
Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p. PMID:29859298
FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer. PMID:29858603
Targeting Rac and Cdc42 GTPases in Cancer. PMID:29858187
Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors. PMID:29858058
Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models. PMID:29856687
LINC00857 expression predicts and mediates the response to platinum-based chemotherapy in muscle-invasive bladder cancer. PMID:29856124
LRP5 regulates the expression of STK40, a new potential target in triple-negative breast cancers. PMID:29854300
Big data in healthcare - the promises, challenges and opportunities from a research perspective: A case study with a model database. PMID:29854102
Splicing dysregulation as a driver of breast cancer. PMID:29848666
IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer. PMID:29847788
Bronchiolar Adenoma: Expansion of the Concept of Ciliated Muconodular Papillary Tumors With Proposal for Revised Terminology Based on Morphologic, Immunophenotypic, and Genomic Analysis of 25 Cases. PMID:29846186
High expression of long non-coding RNA MALAT1 in breast cancer is associated with poor relapse-free survival. PMID:29845475
Cofilin-1 levels and intracellular localization are associated with melanoma prognosis in a cohort of patients. PMID:29844875
Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing. PMID:29844865
PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma. PMID:29844863
RANK-c attenuates aggressive properties of ER-negative breast cancer by inhibiting NF-κB activation and EGFR signaling. PMID:29844572
Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate. PMID:29844571
Whole-Genome Sequencing in Cancer. PMID:29844223
TMPRSS2-ERG Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in PTEN and TP53-Mutated Prostate Cancer. PMID:29844131
The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung. PMID:29802376
Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth. PMID:29802348
Identification of Biological Targets of Therapeutic Intervention for Hepatocellular Carcinoma by Integrated Bioinformatical Analysis. PMID:29795057
Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase in Adrenocortical Carcinoma. PMID:29790920
High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing. PMID:29789573
Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy. PMID:29785026
DARPP-32 and t-DARPP promote non-small cell lung cancer growth through regulation of IKKα-dependent cell migration. PMID:29782621
Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions. PMID:29778097
MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer. PMID:29777112
Targeting invadopodia-mediated breast cancer metastasis by using ABL kinase inhibitors. PMID:29774130
PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia. PMID:29774127
A new method of identifying glioblastoma subtypes and creation of corresponding animal models. PMID:29769617
Targeting BCL-2 regulated apoptosis in cancer. PMID:29769323
Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability. PMID:29769258
Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation. PMID:29767233
VAReporter: variant reporter for cancer research of massive parallel sequencing. PMID:29764369
The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications. PMID:29757368
TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma. PMID:29749538
Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis. PMID:29748619
An anatomic transcriptional atlas of human glioblastoma. PMID:29748285
Dramatic dysbalancing of the Wnt pathway in breast cancers. PMID:29743726
Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer. PMID:29743633
The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia. PMID:29742019
Genetic and Epigenetic Features of Rapidly Progressing IDH-Mutant Astrocytomas. PMID:29741737
PTEN Regulates Nonhomologous End Joining By Epigenetic Induction of NHEJ1/XLF. PMID:29739874
PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic Agent. PMID:29735542
Whole-Exome Sequencing of Sinonasal Small Cell Carcinoma Arising within a Papillary Schneiderian Carcinoma In Situ. PMID:29734873
YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting. PMID:29734788
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. PMID:29733835
Genetic rearrangements, hotspot mutations, and microRNA expression in the progression of metastatic adenoid cystic carcinoma of the salivary gland. PMID:29731974
Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma. PMID:29728763
Robust genomic copy number predictor of pan cancer metastasis. PMID:29725504
Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors. PMID:29725351
SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma. PMID:29724720
Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system. PMID:29721165
Soluble CD146 is a predictive marker of pejorative evolution and of sunitinib efficacy in clear cell renal cell carcinoma. PMID:29721091
Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis. PMID:29720215
Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer. PMID:29717114
VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin. PMID:29717062
Cell division cycle 7 is a potential therapeutic target in oral squamous cell carcinoma and is regulated by E2F1. PMID:29713760
Regulation of DNA damage repair and lipid uptake by CX3CR1 in epithelial ovarian carcinoma. PMID:29712888
Targeting DNA Methyltranferases in Urological Tumors. PMID:29706891
ACTN4 regulates the stability of RIPK1 in melanoma. PMID:29706658
In Silico and In Vitro Analyses of LncRNAs as Potential Regulators in the Transition from the Epithelioid to Sarcomatoid Histotype of Malignant Pleural Mesothelioma (MPM). PMID:29701689
The Correlation Between the Immune and Epithelial-Mesenchymal Transition Signatures Suggests Potential Therapeutic Targets and Prognosis Prediction Approaches in Kidney Cancer. PMID:29700419
Survey and evaluation of mutations in the human KLF1 transcription unit. PMID:29700354
Mutational profiling can identify laryngeal dysplasia at risk of progression to invasive carcinoma. PMID:29700339
Ankyrin repeat and single KH domain 1 (ANKHD1) drives renal cancer cell proliferation via binding to and altering a subset of miRNAs. PMID:29695508
EGFR L861Q Mutation in a Metastatic Solid-pseudopapillary Neoplasm of the Pancreas. PMID:29695402
Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy. PMID:29686284
Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid. PMID:29686061
Copy number changes at 8p11-12 predict adverse clinical outcome and chemo- and radiotherapy response in breast cancer. PMID:29682206
IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma. PMID:29669935
SUZ12 is a novel putative oncogene promoting tumorigenesis in head and neck squamous cell carcinoma. PMID:29667751
Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers. PMID:29665859
High G2 and S-phase expressed 1 expression promotes acral melanoma progression and correlates with poor clinical prognosis. PMID:29660787
Quantitative targeted proteomic analysis of potential markers of tyrosine kinase inhibitor (TKI) sensitivity in EGFR mutated lung adenocarcinoma. PMID:29660496
Optimised ARID1A immunohistochemistry is an accurate predictor of ARID1A mutational status in gynaecological cancers. PMID:29659191
oncoNcRNA: A Web Portal for Exploring the Non-Coding RNAs with Oncogenic Potentials in Human Cancers. PMID:29657279
Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling. PMID:29654229
Genomic Instability Promoted by Overexpression of Mismatch Repair Factors in Yeast: A Model for Understanding Cancer Progression. PMID:29654124
Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma. PMID:29650805
In silico cancer research towards 3R. PMID:29649981
Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer. PMID:29649003
Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior. PMID:29648538
Replication-incompetent gammaretroviral and lentiviral vector-based insertional mutagenesis screens identify prostate cancer progression genes. PMID:29643985
Epigenome-wide association study of metabolic syndrome in African-American adults. PMID:29643945
H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia. PMID:29643943
T cell-induced CSF1 promotes melanoma resistance to PD1 blockade. PMID:29643229
Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers. PMID:29641532
Non-Coding Transcript Heterogeneity in Mesothelioma: Insights from Asbestos-Exposed Mice. PMID:29641489
Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients. PMID:29636477
Disruption of NSD1 in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation. PMID:29636367
Identification of an Unfavorable Immune Signature in Advanced Lung Tumors from Nrf2-Deficient Mice. PMID:29634345
Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer. PMID:29625057
Oncogenic Signaling Pathways in The Cancer Genome Atlas. PMID:29625050
Genetic alterations and PIK3CA gene mutations and amplifications analysis in cervical cancer by racial groups in the United States. PMID:29623014
Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer. PMID:29622797
MORC2, a novel oncogene, is upregulated in liver cancer and contributes to proliferation, metastasis and chemoresistance. PMID:29620211
Prevalent Homozygous Deletions of Type I Interferon and Defensin Genes in Human Cancers Associate with Immunotherapy Resistance. PMID:29618619
Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer. PMID:29618387
A survey and evaluation of Web-based tools/databases for variant analysis of TCGA data. PMID:29617727
A comprehensive analysis of the predicted targets of miR-642b-3p associated with the long non-coding RNA HOXA11-AS in NSCLC cells. PMID:29616096
Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers. PMID:29615613
Mutation Profiling of Key Cancer Genes in Primary Breast Cancers and Their Distant Metastases. PMID:29615433
The long tail of oncogenic drivers in prostate cancer. PMID:29610475
Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making. PMID:29610392
Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. PMID:29604293
Modelling cost-effectiveness of a biomarker-based approach to neoadjuvant chemotherapy for muscle-invasive bladder cancer. PMID:29603871
Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma. PMID:29599922
PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells. PMID:29599917
The emerging clinical relevance of genomics in cancer medicine. PMID:29599476
Dissecting the Mutational Landscape of Cutaneous Melanoma: An Omic Analysis Based on Patients from Greece. PMID:29596374
UBE2C Is a Transcriptional Target of the Cell Cycle Regulator FOXM1. PMID:29596365
RNA-splicing factor SART3 regulates translesion DNA synthesis. PMID:29590477
The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth. PMID:29588411
Comprehensive genomic profiling aids in treatment of a metastatic endometrial cancer. PMID:29588307
miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis. PMID:29587866
Fibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2/ERG fusion gene and decreased PTEN. PMID:29581856
Integrated Oncogenomic Profiling of Copy Numbers and Gene Expression in Lung Adenocarcinomas without EGFR Mutations or ALK Fusion. PMID:29581789
The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer. PMID:29578365
Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer. PMID:29577933
Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer. PMID:29575713
DNA methylation of microRNA-coding genes in non-small-cell lung cancer patients. PMID:29570800
Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer. PMID:29566768
The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours. PMID:29566741
FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma. PMID:29565465
The protein histidine phosphatase LHPP is a tumour suppressor. PMID:29562234
Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis. PMID:29562167
Meta-analysis of CDKN2A methylation to find its role in prostate cancer development and progression, and also to find the effect of CDKN2A expression on disease-free survival (PRISMA). PMID:29561434
QSurface: fast identification of surface expression markers in cancers. PMID:29560830
Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer. PMID:29560115
Effect of CCL5 expression in the recruitment of immune cells in triple negative breast cancer. PMID:29559701
MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation. PMID:29556384
PRL-3 is a potential glioblastoma prognostic marker and promotes glioblastoma progression by enhancing MMP7 through the ERK and JNK pathways. PMID:29556339
MUC16 overexpression induced by gene mutations promotes lung cancer cell growth and invasion. PMID:29552305
SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer. PMID:29547122
Recurrent copy number alterations in young women with breast cancer. PMID:29545918
An integrated approach identifies new oncotargets in melanoma. PMID:29545914
Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice. PMID:29545603
Expression of reactive species related genes is associated with patient survival in luminal B breast cancer. PMID:29545070
The curious case of Gαs gain-of-function in neoplasia. PMID:29544460
Discovery and validation of a glioblastoma co-expressed gene module. PMID:29541392
Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells. PMID:29541388
Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells. PMID:29541196
Double agents: genes with both oncogenic and tumor-suppressor functions. PMID:29540752
CD47 expression in Epstein-Barr virus-associated gastric carcinoma: coexistence with tumor immunity lowering the ratio of CD8+/Foxp3+ T cells. PMID:29536167
Targeting loss of the Hippo signaling pathway in NF2-deficient papillary kidney cancers. PMID:29535838
Nutlin-3a as a novel anticancer agent for adrenocortical carcinoma with CTNNB1 mutation. PMID:29532999
DNA Damage Response in Prostate Cancer. PMID:29530944
A proteomic landscape of diffuse-type gastric cancer. PMID:29520031
CD117/c-kit in Cancer Stem Cell-Mediated Progression and Therapeutic Resistance. PMID:29518044
Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA. PMID:29517810
Efficacy of histology-agnostic and molecularly-driven HER2 inhibitors for refractory cancers. PMID:29515767
TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer. PMID:29515762
PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53. PMID:29511347
An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration. PMID:29510700
DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA. PMID:29509408
LRP1 expression in colon cancer predicts clinical outcome. PMID:29507659
Oncogenic BRAF mutations and p16 expression in melanocytic nevi and melanoma in the Polish population. PMID:29507566
Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening. PMID:29503867
Impact of Phosphoproteomics in the Era of Precision Medicine for Prostate Cancer. PMID:29503809
The role of calgranulin B gene on the biological behavior of squamous cervical cancer in vitro and in vivo. PMID:29497331
Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer. PMID:29497091
Carbonic Anhydrases: Role in pH Control and Cancer. PMID:29495652
Intrahepatic cholangiocarcinoma: can imaging phenotypes predict survival and tumor genetics? PMID:29492607
Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells. PMID:29492203
Profiling the interactome of protein kinase C ζ by proteomics and bioinformatics. PMID:29491746
UBASH3B-mediated silencing of the mitotic checkpoint: Therapeutic perspectives in cancer. PMID:29487893
Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma. PMID:29487705
The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection. PMID:29487696
Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression. PMID:29487338
ERK5 is activated by oncogenic BRAF and promotes melanoma growth. PMID:29483645
Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties. PMID:29483135
The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma. PMID:29481555
[Ewing sarcomas and Ewing-like sarcomas : New aspects]. PMID:29480450
Epigenetic silencing of RNF144A expression in breast cancer cells through promoter hypermethylation and MBD4. PMID:29473320
Adhesion GPCRs in Kidney Development and Disease. PMID:29468160
Identification of the potential crucial genes in invasive ductal carcinoma using bioinformatics analysis. PMID:29467930
Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer. PMID:29465762
The transcriptional and mutational landscapes of lipid metabolism-related genes in colon cancer. PMID:29464044
Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression. PMID:29463646
The Role of the Estrogen Pathway in the Tumor Microenvironment. PMID:29463044
The INO80 chromatin remodeler sustains metabolic stability by promoting TOR signaling and regulating histone acetylation. PMID:29462149
Identification of novel prognosis-related genes associated with cancer using integrative network analysis. PMID:29459674
Recon3D enables a three-dimensional view of gene variation in human metabolism. PMID:29457794
SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer. PMID:29456503
The role of RICTOR downstream of receptor tyrosine kinase in cancers. PMID:29455662
Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling. PMID:29448085
Dexamethasone-Mediated Upregulation of Calreticulin Inhibits Primary Human Glioblastoma Dispersal Ex Vivo. PMID:29443896
Interleukin-6 and Interferon-α Signaling via JAK1-STAT Differentially Regulate Oncolytic versus Cytoprotective Antiviral States. PMID:29441069
Targeting the MAPK Pathway in RAS Mutant Cancers. PMID:29440321
KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis. PMID:29440247
Oncogenic Kinase-Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem-like Cells. PMID:29440169
Lipid metabolism and lipophagy in cancer. PMID:29438712
HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging. PMID:29437790
Expression and function of nuclear receptor coactivator 4 isoforms in transformed endometriotic and malignant ovarian cells. PMID:29435183
Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma. PMID:29435132
APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response. PMID:29435122
Karyopherin subunit-α 2 expression accelerates cell cycle progression by upregulating CCNB2 and CDK1 in hepatocellular carcinoma. PMID:29435009
Characterization and validation of potential therapeutic targets based on the molecular signature of patient-derived xenografts in gastric cancer. PMID:29433585
GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling. PMID:29431615
Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer. PMID:29430503
The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity. PMID:29429988
Comprehensive review of genetic factors contributing to head and neck squamous cell carcinoma development in low-risk, nontraditional patients. PMID:29427520
Clinical outcomes and differential effects of PI3K pathway mutation in obese versus non-obese patients with cervical cancer. PMID:29423104
Validation of a hypoxia related gene signature in multiple soft tissue sarcoma cohorts. PMID:29423096
Systematic analysis of gene expression alterations and clinical outcomes of STAT3 in cancer. PMID:29423040
Leveraging Genomics for Head and Neck Cancer Treatment. PMID:29420101
Impact of novel oncogenic pathways regulated by antitumor miR-451a in renal cell carcinoma. PMID:29417701
Mechanism of action of the atypical retinoid ST1926 in colorectal cancer: DNA damage and DNA polymerase α. PMID:29416919
SIRT1 contributes to neuroendocrine differentiation of prostate cancer. PMID:29416748
Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction. PMID:29416706
Cooperation between ZEB2 and Sp1 promotes cancer cell survival and angiogenesis during metastasis through induction of survivin and VEGF. PMID:29416649
The prognostic significance of nuclear expression of PHF2 and C/EBPα in clear cell renal cell carcinoma with consideration of adipogenic metabolic evolution. PMID:29416602
LanCL1 protects prostate cancer cells from oxidative stress via suppression of JNK pathway. PMID:29416001
Mutational Profiling of Malignant Mesothelioma Revealed Potential Therapeutic Targets in EGFR and NRAS. PMID:29413759
MicroRNA-10b expression in breast cancer and its clinical association. PMID:29408861
Targeting the IL-6/JAK/STAT3 signalling axis in cancer. PMID:29405201
Recovery of Immunoglobulin VJ Recombinations from Pancreatic Cancer Exome Files Strongly Correlates with Reduced Survival. PMID:29404962
BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1. PMID:29402932
RNA-protein interaction detection in living cells. PMID:29400715
Cellular vaccination of MLH1-/- mice - an immunotherapeutic proof of concept study. PMID:29399413
Bromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune-environment. PMID:29399399
Mixed lineage kinase ZAK promotes epithelial-mesenchymal transition in cancer progression. PMID:29396440
G2S: a web-service for annotating genomic variants on 3D protein structures. PMID:29385402
Regulation of Cancer Stem Cell Metabolism by Secreted Frizzled-Related Protein 4 (sFRP4). PMID:29385093
Tumor exome sequencing and copy number alterations reveal potential predictors of intrinsic resistance to multi-targeted tyrosine kinase inhibitors. PMID:29383146
Overexpression of HSD17B4 exerts tumor suppressive function in adrenocortical carcinoma and is not associated with hormone excess. PMID:29383116
CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway. PMID:29383104
Development of a personalized therapeutic strategy for ERBB-gene-mutated cancers. PMID:29383036
Optimized targeted sequencing of cell-free plasma DNA from bladder cancer patients. PMID:29382943
Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. PMID:29381681
Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer. PMID:29378962
Mitotically-Associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer. PMID:29378907
Genomic analysis of head and neck cancer cases from two high incidence regions. PMID:29377909
Cisplatin and Pemetrexed Activate AXL and AXL Inhibitor BGB324 Enhances Mesothelioma Cell Death from Chemotherapy. PMID:29375377
Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension. PMID:29372107
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma. PMID:29371990
Suppressor of fused (Sufu) promotes epithelial-mesenchymal transition (EMT) in cervical squamous cell carcinoma. PMID:29371981
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors. PMID:29371290
Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production. PMID:29367762
miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis. PMID:29367737
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. PMID:29364867
Hybrid Capture-Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus. PMID:29363525
α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration. PMID:29361527
TcR-α recombinations in renal cell carcinoma exome files correlate with an intermediate level of T-cell exhaustion biomarkers. PMID:29361059
A core matrisome gene signature predicts cancer outcome. PMID:29360819
COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors. PMID:29360641
Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions. PMID:29358619
Immunogenomics: A Negative Prostate Cancer Outcome Associated with TcR-γ/δ Recombinations. PMID:29357011
SALL4 - KHDRBS3 network enhances stemness by modulating CD44 splicing in basal-like breast cancer. PMID:29356399
Syndecan-1 Controls Lung Tumorigenesis by Regulating miRNAs Packaged in Exosomes. PMID:29355516
qPortal: A platform for data-driven biomedical research. PMID:29352322
Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae. PMID:29352080
CCAT1 stimulation of the symmetric division of NSCLC stem cells through activation of the Wnt signalling cascade. PMID:29350683
Overexpression of adhesion molecules and barrier molecules is associated with differential infiltration of immune cells in non-small cell lung cancer. PMID:29348685
Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma. PMID:29348488
SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1. PMID:29348142
Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia. PMID:29346763
The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer. PMID:29346117
Identification of key pathways and genes in TP53 mutation acute myeloid leukemia: evidence from bioinformatics analysis. PMID:29343974
The protective role of DOT1L in UV-induced melanomagenesis. PMID:29343685
Identification of novel diagnostic biomarkers for thyroid carcinoma. PMID:29340074
Clinicopathological and prognostic significance of SDC1 overexpression in breast cancer. PMID:29340066
A molecular signature of dormancy in CD34+CD38- acute myeloid leukaemia cells. PMID:29340063
MCL-1 is a prognostic indicator and drug target in breast cancer. PMID:29339815
An orthotopic mouse model of gastric cancer invasion and metastasis. PMID:29339747
IDH1/2 Mutations Sensitize Acute Myeloid Leukemia to PARP Inhibition and This Is Reversed by IDH1/2-Mutant Inhibitors. PMID:29339439
Gene and MicroRNA Perturbations of Cellular Response to Pemetrexed Implicate Biological Networks and Enable Imputation of Response in Lung Adenocarcinoma. PMID:29335598
Cytoplasmic collagen XIαI as a prognostic biomarker in esophageal squamous cell carcinoma. PMID:29333916
Functional transcriptomic annotation and protein-protein interaction network analysis identify NEK2, BIRC5, and TOP2A as potential targets in obese patients with luminal A breast cancer. PMID:29330624
Lung fibroblasts promote metastatic colonization through upregulation of stearoyl-CoA desaturase 1 in tumor cells. PMID:29326439
Tumor purity quantification by clonal DNA methylation signatures. PMID:29325057
Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis. PMID:29321207
Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer. PMID:29316426
Dual inhibition of Wnt and Yes-associated protein signaling retards the growth of triple-negative breast cancer in both mesenchymal and epithelial states. PMID:29316250
Precision Medicine in Children and Young Adults with Hematologic Malignancies and Blood Disorders: The Columbia University Experience. PMID:29312904
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma. PMID:29312802
B-CAN: a resource sharing platform to improve the operation, visualization and integrated analysis of TCGA breast cancer data. PMID:29312567
MRAS: A Close but Understudied Member of the RAS Family. PMID:29311130
Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer. PMID:29311118
Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms. PMID:29309058
Long interspersed nuclear element-1 expression and retrotransposition in prostate cancer cells. PMID:29308092
Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer. PMID:29306329
Identification of specific feed-forward apoptosis mechanisms and associated higher survival rates for low grade glioma and lung squamous cell carcinoma. PMID:29305708
Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer. PMID:29298117
Incorporating biological prior knowledge for Bayesian learning via maximal knowledge-driven information priors. PMID:29297278
TFF1 hypermethylation and decreased expression in esophageal squamous cell carcinoma and histologically normal tumor surrounding esophageal cells. PMID:29296124
The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division. PMID:29295957
Context-Dependent Role of IKKβ in Cancer. PMID:29292732
Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer. PMID:29290965
Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profile in Pancreatic Cancer Derived Exosomes Treated Dendritic Cells by Microarray Analysis. PMID:29290766
PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors. PMID:29284706
AKT3 drives adenoid cystic carcinoma development in salivary glands. PMID:29282901
ZDHHC3 as a Risk and Mortality Marker for Breast Cancer in African American Women. PMID:29276372
Methylation-regulated decommissioning of multimeric PP2A complexes. PMID:29273778
EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients. PMID:29272522
Bioinformatics for precision oncology. PMID:29272324
Usability and Suitability of the Omics-Integrating Analysis Platform tranSMART for Translational Research and Education. PMID:29270954
VaDiR: an integrated approach to Variant Detection in RNA. PMID:29267927
Identification of potentially oncogenic alterations from tumor-only samples reveals Fanconi anemia pathway mutations in bladder carcinomas. PMID:29263839
Triple Angiokinase Inhibitor Nintedanib Directly Inhibits Tumor Cell Growth and Induces Tumor Shrinkage via Blocking Oncogenic Receptor Tyrosine Kinases. PMID:29263244
Chk1 modulates the interaction between myosin phosphatase targeting protein 1 (MYPT1) and protein phosphatase 1cβ (PP1cβ). PMID:29262732
Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53. PMID:29262616
Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model. PMID:29262598
GATA3 frameshift mutation promotes tumor growth in human luminal breast cancer cells and induces transcriptional changes seen in primary GATA3 mutant breast cancers. PMID:29262572
Identification of SPOP related metabolic pathways in prostate cancer. PMID:29262542
High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism. PMID:29262533
PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression. PMID:29262329
Combination of palbociclib with enzalutamide shows in vitro activity in RB proficient and androgen receptor positive triple negative breast cancer cells. PMID:29261702
High expression of FLT3 is a risk factor in leukemia. PMID:29257272
GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers. PMID:29255247
Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework. PMID:29254494
Development and validation of a targeted next generation DNA sequencing panel outperforming whole exome sequencing for the identification of clinically relevant genetic variants. PMID:29254223
Therapeutic potential of an anti-angiogenic multimodal biomimetic peptide in hepatocellular carcinoma. PMID:29254183
Accelerating Discovery of Functional Mutant Alleles in Cancer. PMID:29247016
Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling. PMID:29246230
High expression of lncRNA PVT1 independently predicts poor overall survival in patients with primary uveal melanoma. PMID:29244840
Targeting mutant p53 for efficient cancer therapy. PMID:29242642
Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer. PMID:29242529
Ornithine decarboxylase as a therapeutic target for endometrial cancer. PMID:29240775
Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7. PMID:29235476
SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis. PMID:29234151
Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity. PMID:29233960
Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. PMID:29232553
Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review. PMID:29230671
EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. PMID:29229958
Identification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach. PMID:29229936
Identification of cancer genes that are independent of dominant proliferation and lineage programs. PMID:29229826
SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer. PMID:29229751
Genes with mutation significance were highly associated with the clinical pattern of patients with breast cancer. PMID:29228676
Subependymal giant cell astrocytomas in Tuberous Sclerosis Complex have consistent TSC1/TSC2 biallelic inactivation, and no BRAF mutations. PMID:29221145
CTD2 Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network. PMID:29220450
Role of Dopamine Receptors in the Anticancer Activity of ONC201. PMID:29216597
Chromosome 9p copy number gains involving PD-L1 are associated with a specific proliferation and immune-modulating gene expression program active across major cancer types. PMID:29212506
Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer. PMID:29210986
Prediction of early-stage hepatocellular carcinoma using OncoScan chromosomal copy number aberration data. PMID:29209123
Robust method for identification of prognostic gene signatures from gene expression profiles. PMID:29208919
Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response. PMID:29208897
Matrix metalloproteinase-1 expression in breast carcinoma: a marker for unfavorable prognosis. PMID:29207651
Cancer-mutated ribosome protein L22 (RPL22/eL22) suppresses cancer cell survival by blocking p53-MDM2 circuit. PMID:29207594
Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous. PMID:29203670
Pharmacological inhibition of Bmi1 by PTC-209 impaired tumor growth in head neck squamous cell carcinoma. PMID:29200967
Regulation of HMGB3 by antitumor miR-205-5p inhibits cancer cell aggressiveness and is involved in prostate cancer pathogenesis. PMID:29196733
Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage. PMID:29192276
Profiling of the transcriptional response to all-trans retinoic acid in breast cancer cells reveals RARE-independent mechanisms of gene expression. PMID:29192143
Genes co-amplified with ERBB2 or MET as novel potential cancer-promoting genes in gastric cancer. PMID:29190909
High bone marrow ID2 expression predicts poor chemotherapy response and prognosis in acute myeloid leukemia. PMID:29190891
Toll-like receptor expression in human non-small cell lung carcinoma: potential prognostic indicators of disease. PMID:29190881
Decreased KPNB1 Expression is Induced by PLK1 Inhibition and Leads to Apoptosis in Lung Adenocarcinoma. PMID:29187890
Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling. PMID:29187877
JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component. PMID:29187213
JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion. PMID:29186616
PKK deletion in basal keratinocytes promotes tumorigenesis after chemical carcinogenesis. PMID:29186361
The OncoPPi Portal: an integrative resource to explore and prioritize protein-protein interactions for cancer target discovery. PMID:29186335
Predicting cancer type from tumour DNA signatures. PMID:29183400
Investigation of fusion gene expression in HCT116 cells. PMID:29181107
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. PMID:29180628
t-Darpp Activates IGF-1R Signaling to Regulate Glucose Metabolism in Trastuzumab-Resistant Breast Cancer Cells. PMID:29180608
Small-Cell Carcinomas of the Bladder and Lung Are Characterized by a Convergent but Distinct Pathogenesis. PMID:29180607
DNAJB1-PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma. PMID:29162699
Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer. PMID:29161592
Next-generation Sequencing-based genomic profiling: Fostering innovation in cancer care? PMID:29160420
Activating FGFR1 Mutations in Sporadic Pheochromocytomas. PMID:29159601
In silico and in vitro identification of inhibitory activities of sorafenib on histone deacetylases in hepatocellular carcinoma cells. PMID:29156785
Epigenetic silencing of tumor suppressor candidate 3 confers adverse prognosis in early colorectal cancer. PMID:29156678
β-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic β-catenin and MET. PMID:29152756
Functional network analysis of gene-phenotype connectivity associated with temozolomide. PMID:29152101
Therapeutic Potential of Afatinib for Cancers with ERBB2 (HER2) Transmembrane Domain Mutations G660D and V659E. PMID:29146616
mSignatureDB: a database for deciphering mutational signatures in human cancers. PMID:29145625
Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation. PMID:29143738
Salt bridges gate α-catenin activation at intercellular junctions. PMID:29142072
Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines. PMID:29141224
Copy number gains at chr3p25 and chr11p11 are associated with lymph node involvement and survival in muscle-invasive bladder tumors. PMID:29140994
Lack of both androgen receptor and forkhead box A1 (FOXA1) expression is a poor prognostic factor in estrogen receptor-positive breast cancers. PMID:29137314
Vinculin and filamin-C are two potential prognostic biomarkers and therapeutic targets for prostate cancer cell migration. PMID:29137275
The Rho GTPase signalling pathway in urothelial carcinoma. PMID:29133936
Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer. PMID:29133620
An NRG Oncology/GOG study of molecular classification for risk prediction in endometrioid endometrial cancer. PMID:29132872
Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures. PMID:29130628
Systematically linking tranSMART, Galaxy and EGA for reusing human translational research data. PMID:29123641
Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer. PMID:29122777
Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion. PMID:29121062
KRAS Mutation in Gastric Cancer and Prognostication Associated with Microsatellite Instability Status. PMID:29116623
Overexpression of lamin B1 induces mitotic catastrophe in colon cancer LoVo cells and is associated with worse clinical outcomes. PMID:29115590
Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer. PMID:29112949
Comprehensive bioinformatics analysis of the characterization and determination underlying mechanisms of over-expression and co-expression of genes residing on 20q in colorectal cancer. PMID:29108255
STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. PMID:29108249
Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells. PMID:29107110
Clinical Implications of NRAS Overexpression in Resectable Pancreatic Adenocarcinoma Patients. PMID:29101736
Combined Small Cell Carcinoma of the Lung: Is It a Single Entity? PMID:29101056
The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1. PMID:29100415
Gene network inherent in genomic big data improves the accuracy of prognostic prediction for cancer patients. PMID:29100405
RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner. PMID:29100281
Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein. PMID:29100040
PAX5 gene as a novel methylation marker that predicts both clinical outcome and cisplatin sensitivity in esophageal squamous cell carcinoma. PMID:29099287
Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma. PMID:29093438
"Personalized Cancer Therapy": A Publicly Available Precision Oncology Resource. PMID:29092956
A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data. PMID:29092932
Transition state-based ST6Gal I inhibitors: Mimicking the phosphodiester linkage with a triazole or carbamate through an enthalpy-entropy compensation. PMID:29089525
Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer. PMID:29089489
Prevalence of Aflatoxin-Associated TP53R249S Mutation in Hepatocellular Carcinoma in Hispanics in South Texas. PMID:29089331
Neuropilin-1 is a glial cell line-derived neurotrophic factor receptor in glioblastoma. PMID:29088765
HCMDB: the human cancer metastasis database. PMID:29088455
Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis. PMID:29088297
Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival. PMID:29088295
High ECT2 expression is an independent prognostic factor for poor overall survival and recurrence-free survival in non-small cell lung adenocarcinoma. PMID:29088286
Sortilin limits EGFR signaling by promoting its internalization in lung cancer. PMID:29084952
Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. PMID:29084603
ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells. PMID:29084210
C10orf116 Gene Copy Number Loss in Prostate Cancer: Clinicopathological Correlations and Prognostic Significance. PMID:29084195
Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications. PMID:29082853
Vitamin D Receptor Signaling and Cancer. PMID:29080633
Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas. PMID:29077933
Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers. PMID:29073199
Resistance to checkpoint blockade therapy through inactivation of antigen presentation. PMID:29070816
Circulating tumor DNA detection in head and neck cancer: evaluation of two different detection approaches. PMID:29069814
SEECancer: a resource for somatic events in evolution of cancer genome. PMID:29069402
Mutation analysis and copy number alterations of KIF23 in non-small-cell lung cancer exhibiting KIF23 over-expression. PMID:29066916
Signaling by cell surface death receptors: Alterations in head and neck cancer. PMID:29066276
Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism. PMID:29063830
Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. PMID:29059430
SBCDDB: Sleeping Beauty Cancer Driver Database for gene discovery in mouse models of human cancers. PMID:29059366
Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB. PMID:29059167
PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K. PMID:29056325
Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence. PMID:29055014
NRF2-regulated metabolic gene signature as a prognostic biomarker in non-small cell lung cancer. PMID:29050246
A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates. PMID:29049289
Gastric cancer: immunohistochemical classification of molecular subtypes and their association with clinicopathological characteristics. PMID:29046940
Protein Phosphatase Magnesium-Dependent 1δ (PPM1D) Expression as a Prognostic Marker in Adult Supratentorial Diffuse Astrocytic and Oligodendroglial Tumors. PMID:29046514
Clinical and molecular characterization of patients with cancer of unknown primary in the modern era. PMID:29045506
Dysbindin promotes progression of pancreatic ductal adenocarcinoma via direct activation of PI3K. PMID:29040676
Genomics alterations of metastatic and primary tissues across 15 cancer types. PMID:29038591
A novel machine learning approach reveals latent vascular phenotypes predictive of renal cancer outcome. PMID:29038551
Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. PMID:29035366
Genomic insights into head and neck cancer. PMID:29034103
MDM2 Antagonists Counteract Drug-Induced DNA Damage. PMID:29030058
Environment and bladder cancer: molecular analysis by interaction networks. PMID:29029427
OncomiR: an online resource for exploring pan-cancer microRNA dysregulation. PMID:29028907
Subtle Deregulation of the Wnt-Signaling Pathway Through Loss of Apc2 Reduces the Fitness of Intestinal Stem Cells. PMID:29027285
Mutational landscape of RNA-binding proteins in human cancers. PMID:29023197
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. PMID:29021522
Metabolite Profiling Reveals the Glutathione Biosynthetic Pathway as a Therapeutic Target in Triple-Negative Breast Cancer. PMID:29021292
Targeting apoptosis in acute myeloid leukaemia. PMID:29017180
Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment. PMID:29016864
Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation. PMID:29016808
Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors. PMID:28993411
ESRP1 is overexpressed in ovarian cancer and promotes switching from mesenchymal to epithelial phenotype in ovarian cancer cells. PMID:28991261
Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer. PMID:28984209
Unique protein expression signatures of survival time in kidney renal clear cell carcinoma through a pan-cancer screening. PMID:28984208
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation. PMID:28978427
SLC2A2 (GLUT2) as a novel prognostic factor for hepatocellular carcinoma. PMID:28978124
Genetic profile and biological implication of PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) in human cancers: an analysis using The Cancer Genome Atlas. PMID:28978030
Genomic alterations in mucins across cancers. PMID:28978023
Overexpression of the E2F target gene CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer. PMID:28977935
NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization. PMID:28977907
Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer. PMID:28977839
BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing. PMID:28976962
Resources for Interpreting Variants in Precision Genomic Oncology Applications. PMID:28975082
Revisiting the impact of age and molecular subtype on overall survival after radiotherapy in breast cancer patients. PMID:28974723
Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation. PMID:28970512
Functional Impact of Chromatin Remodeling Gene Mutations and Predictive Signature for Therapeutic Response in Bladder Cancer. PMID:28970362
Decoy receptor 1 (DCR1) promoter hypermethylation and response to irinotecan in metastatic colorectal cancer. PMID:28968978
Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence. PMID:28967919
Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer. PMID:28966724
Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor. PMID:28963353
Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer. PMID:28958991
KRAS Alleles: The Devil Is in the Detail. PMID:28958387
PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma. PMID:28951458
miR-367 stimulates Wnt cascade activation through degrading FBXW7 in NSCLC stem cells. PMID:28949784
miR-33a is a tumor suppressor microRNA that is decreased in prostate cancer. PMID:28947967
A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival. PMID:28947735
Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. PMID:28945232
Xanthine dehydrogenase downregulation promotes TGFβ signaling and cancer stem cell-related gene expression in hepatocellular carcinoma. PMID:28945217
The FOXA2 transcription factor is frequently somatically mutated in uterine carcinosarcomas and carcinomas. PMID:28940304
Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation. PMID:28939681
Prostate Tumor Overexpressed-1 (PTOV1) promotes docetaxel-resistance and survival of castration resistant prostate cancer cells. PMID:28938627
Long non-coding RNAs may serve as biomarkers in breast cancer combined with primary lung cancer. PMID:28938549
Integrated molecular analysis of Tamoxifen-resistant invasive lobular breast cancer cells identifies MAPK and GRM/mGluR signaling as therapeutic vulnerabilities. PMID:28935545
Methylation associated transcriptional repression of ELOVL5 in novel colorectal cancer cell lines. PMID:28931069
p16 Methylation was associated with the development, age, hepatic viruses infection of hepatocellular carcinoma, and p16 expression had a poor survival: A systematic meta-analysis (PRISMA). PMID:28930859
Overexpression of MUC1 and Genomic Alterations in Its Network Associate with Prostate Cancer Progression. PMID:28930697
Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer. PMID:28928458
HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. PMID:28928286
The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK. PMID:28928239
Targeting a Single Alternative Polyadenylation Site Coordinately Blocks Expression of Androgen Receptor mRNA Splice Variants in Prostate Cancer. PMID:28928128
Loss of RUNX1 is associated with aggressive lung adenocarcinomas. PMID:28926105
Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling. PMID:28925397
The EEF1A2 gene expression as risk predictor in localized prostate cancer. PMID:28923030
Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma. PMID:28920960
The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism. PMID:28916726
Genomic analysis of exceptional responder to regorafenib in treatment-refractory metastatic rectal cancer: a case report and review of the literature. PMID:28915719
Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β. PMID:28915558
Identification of a novel p53 target, COL17A1, that inhibits breast cancer cell migration and invasion. PMID:28915553
Genomic Analysis of Tumor Microenvironment Immune Types across 14 Solid Cancer Types: Immunotherapeutic Implications. PMID:28912897
Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures. PMID:28912153
Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer. PMID:28904132
Screening and identification of key biomarkers in hepatocellular carcinoma: Evidence from bioinformatic analysis. PMID:28901457
A BAP1 Mutation-specific MicroRNA Signature Predicts Clinical Outcomes in Clear Cell Renal Cell Carcinoma Patients with Wild-type BAP1. PMID:28900502
TMEM16A/ANO1 Inhibits Apoptosis Via Downregulation of Bim Expression. PMID:28899969
Associations of two-pore domain potassium channels and triple negative breast cancer subtype in The Cancer Genome Atlas: systematic evaluation of gene expression and methylation. PMID:28899398
The genetic landscape of programmed death ligand-1 (PD-L1) alterations in head and neck cancer. PMID:28894827
Involvement of DPP9 in gene fusions in serous ovarian carcinoma. PMID:28893231
A system for detecting high impact-low frequency mutations in primary tumors and metastases. PMID:28892047
Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. PMID:28891816
OncoKB: A Precision Oncology Knowledge Base. PMID:28890946
MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer. PMID:28888037
p53 gain-of-function mutations increase Cdc7-dependent replication initiation. PMID:28887320
Expression of SESN1, UHRF1BP1, and miR-377-3p as prognostic markers in mutated TP53 squamous cell carcinoma of the head and neck. PMID:28886272
Integrated expression profiles analysis reveals novel predictive biomarker in pancreatic ductal adenocarcinoma. PMID:28881752
Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma. PMID:28881735
BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1). PMID:28881656
A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas. PMID:28881577
Signatures derived from increase in SHARPIN gene copy number are associated with poor prognosis in patients with breast cancer. PMID:28879097
SPEN, a new player in primary cilia formation and cell migration in breast cancer. PMID:28877752
Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia. PMID:28870994
Dynamic Change of Transcription Pausing through Modulating NELF Protein Stability Regulates Granulocytic Differentiation. PMID:28868519
Gene Delivery in Neuro-Oncology. PMID:28866732
Clinical significance and prospective molecular mechanism of MALAT1 in pancreatic cancer exploration: a comprehensive study based on the GeneChip, GEO, Oncomine, and TCGA databases. PMID:28860807
PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer. PMID:28860563
Blood-brain barrier-adapted precision medicine therapy for pediatric brain tumors. PMID:28860053
A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes. PMID:28859688
Spatial and temporal epithelial ovarian cancer cell heterogeneity impacts Maraba virus oncolytic potential. PMID:28854921
Mutational heterogeneity in non-serous ovarian cancers. PMID:28852190
Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs. PMID:28850223
Identification of prognostic markers of high grade prostate cancer through an integrated bioinformatics approach. PMID:28849390
TP63 mutations are frequent in cutaneous melanoma, support UV etiology, but their role in melanomagenesis is unclear. PMID:28849221
HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells. PMID:28842558
The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer. PMID:28842505
Lung adenocarcinoma: from molecular basis to genome-guided therapy and immunotherapy. PMID:28840016
The Neddylation Inhibitor Pevonedistat (MLN4924) Suppresses and Radiosensitizes Head and Neck Squamous Carcinoma Cells and Tumors. PMID:28838998
Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas. PMID:28836293
Expression of neurotensin receptor 1 in endometrial adenocarcinoma is correlated with histological grade and clinical outcome. PMID:28836043
The scaffold protein Ajuba suppresses CdGAP activity in epithelia to maintain stable cell-cell contacts. PMID:28835688
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. PMID:28834754
SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis. PMID:28827661
Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. PMID:28827401
Identification of NRAS isoform 2 overexpression as a mechanism facilitating BRAF inhibitor resistance in malignant melanoma. PMID:28827320
A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer. PMID:28826481
Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making. PMID:28825054
Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. PMID:28820959
MAP2K1 Mutation in Colorectal Cancer Patients: Therapeutic Challenge Using Patient-Derived Tumor Cell Lines. PMID:28819429
Single-Color Digital PCR Provides High-Performance Detection of Cancer Mutations from Circulating DNA. PMID:28818432
"UPRegulation" of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses. PMID:28815041
MTG16 is a tumor suppressor in colitis-associated carcinoma. PMID:28814670
An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis. PMID:28813674
CDK4/6 inhibition triggers anti-tumour immunity. PMID:28813415
ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. PMID:28808226
Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence. PMID:28807943
Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors. PMID:28807940
Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish. PMID:28806732
Loss of MutL Disrupts CHK2-Dependent Cell-Cycle Control through CDK4/6 to Promote Intrinsic Endocrine Therapy Resistance in Primary Breast Cancer. PMID:28801307
Lumican delays melanoma growth in mice and drives tumor molecular assembly as well as response to matrix-targeted TAX2 therapeutic peptide. PMID:28794454
Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance. PMID:28794284
Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth. PMID:28794006
Metalloprotease-dependent activation of EGFR modulates CD44+/CD24- populations in triple negative breast cancer cells through the MEK/ERK pathway. PMID:28791489
Expression of CD70 (CD27L) Is Associated With Epithelioid and Sarcomatous Features in IDH-Wild-Type Glioblastoma. PMID:28789475
PIK3R1Met326Ile germline mutation correlates with cysteine-rich protein 61 expression and poor prognosis in glioblastoma. PMID:28785028
Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma. PMID:28784174
Identification of essential genes for cancer immunotherapy. PMID:28783722
The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma. PMID:28783171
Amplification of the NSD3-BRD4-CHD8 pathway in pelvic high-grade serous carcinomas of tubo-ovarian and endometrial origin. PMID:28781807
Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes. PMID:28771473
Nicotinic acid: A case for a vitamin that moonlights for cancer? PMID:28771080
Endothelial protein C receptor is overexpressed in colorectal cancer as a result of amplification and hypomethylation of chromosome 20q. PMID:28770100
Molecular Characterization of Somatic Alterations in Dukes' B and C Colorectal Cancers by Targeted Sequencing. PMID:28769798
Sexual dimorphism in glioma glycolysis underlies sex differences in survival. PMID:28768910
Deleterious Effect of RAS and Evolutionary High-risk TP53 Double Mutation in Colorectal Liver Metastases. PMID:28767562
Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines. PMID:28767070
Targeting latency-associated peptide promotes antitumor immunity. PMID:28763794
UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept. PMID:28763470
Oncogenic KRAS and p53 Loss Drive Gastric Tumorigenesis in Mice That Can Be Attenuated by E-Cadherin Expression. PMID:28760854
TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis. PMID:28759040
Cell genomics and immunosuppressive biomarker expression influence PD-L1 immunotherapy treatment responses in HNSCC-a computational study. PMID:28756882
Vaccines targeting helper T cells for cancer immunotherapy. PMID:28755541
NSD1 Inactivation and SETD2 Mutation Drive a Convergence toward Loss of Function of H3K36 Writers in Clear Cell Renal Cell Carcinomas. PMID:28754676
The Landscape of Whole-genome Alterations and Pathologic Features in Genitourinary Malignancies: An Analysis of the Cancer Genome Atlas. PMID:28753846
Exome sequencing identifies recurrent BCOR alterations and the absence of KLF2, TNFAIP3 and MYD88 mutations in splenic diffuse red pulp small B-cell lymphoma. PMID:28751561
Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer. PMID:28751448
Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies. PMID:28750640
Mutations targeting the coagulation pathway are enriched in brain metastases. PMID:28747664
AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination. PMID:28747635
PSMA-Targeted Theranostic Nanocarrier for Prostate Cancer. PMID:28744329
Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types. PMID:28743916
Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas. PMID:28742845
Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia. PMID:28742792
Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor. PMID:28741798
Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. PMID:28735896
UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses. PMID:28732212
Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells. PMID:28731456
Renal cell tumors with clear cell histology and intact VHL and chromosome 3p: a histological review of tumors from the Cancer Genome Atlas database. PMID:28731045
Mutational analysis of driver genes with tumor suppressive and oncogenic roles in gastric cancer. PMID:28729958
Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer. PMID:28724614
Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer. PMID:28717230
Clinical Significance and Effect of lncRNA HOXA11-AS in NSCLC: A Study Based on Bioinformatics, In Vitro and in Vivo Verification. PMID:28717185
Association Of Plasma And Urinary Mutant DNA With Clinical Outcomes In Muscle Invasive Bladder Cancer. PMID:28717136
IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model. PMID:28714957
Combined deletion and DNA methylation result in silencing of FAM107A gene in laryngeal tumors. PMID:28710449
DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes. PMID:28706277
Detection of early pancreatic ductal adenocarcinoma with thrombospondin-2 and CA19-9 blood markers. PMID:28701476
Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing. PMID:28692054
Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts. PMID:28691904
RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis. PMID:28689994
De-escalation of treatment in HER2-positive breast cancer: Determinants of response and mechanisms of resistance. PMID:28687441
Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy. PMID:28687338
The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer. PMID:28684677
Epistasis in genomic and survival data of cancer patients. PMID:28678836
Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells. PMID:28678170
Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF. PMID:28676500
Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer. PMID:28675450
The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers. PMID:28674494
Genetic association analysis of the RTK/ERK pathway with aggressive prostate cancer highlights the potential role of CCND2 in disease progression. PMID:28674394
Mechanical cue-induced YAP instructs Skp2-dependent cell cycle exit and oncogenic signaling. PMID:28673931
Next-Generation DNA Curtains for Single-Molecule Studies of Homologous Recombination. PMID:28668123
RGIFE: a ranked guided iterative feature elimination heuristic for the identification of biomarkers. PMID:28666416
Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition. PMID:28659312
Stroma-derived Fibrinogen-like Protein 2 Activates Cancer-associated Fibroblasts to Promote Tumor Growth in Lung Cancer. PMID:28656005
PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma. PMID:28654422
CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers. PMID:28653662
Genome-wide loss-of-function genetic screening identifies opioid receptor μ1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia. PMID:28650467
Genotranscriptomic meta-analysis of the CHD family chromatin remodelers in human cancers - initial evidence of an oncogenic role for CHD7. PMID:28649742
Application of open-access databases to determine functional connectivity between resveratrol-binding protein QR2 and colorectal carcinoma. PMID:28646291
Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer. PMID:28641578
Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer. PMID:28641312
Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression. PMID:28639619
The NF1 somatic mutational landscape in sporadic human cancers. PMID:28637487
Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency. PMID:28636652
Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cells. PMID:28635133
Molecular regulation and pharmacological targeting of the β-catenin destruction complex. PMID:28634996
How Schwann cells facilitate cancer progression in nerves. PMID:28631007
PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α. PMID:28630349
Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells. PMID:28623304
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. PMID:28622513
Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer. PMID:28621677
Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival. PMID:28621318
Structural insights into the function of ZRANB3 in replication stress response. PMID:28621305
Insights from Global Analyses of Long Noncoding RNAs in Breast Cancer. PMID:28616363
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. PMID:28614802
Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma. PMID:28614736
Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death. PMID:28613975
Tumor diversity and evolution revealed through RADseq. PMID:28611298
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. PMID:28611215
FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC. PMID:28607447
Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT. PMID:28604746
The NCI Genomic Data Commons as an engine for precision medicine. PMID:28600341
p90RSK Blockade Inhibits Dual BRAF and MEK Inhibitor-Resistant Melanoma by Targeting Protein Synthesis. PMID:28599981
Cholesterol uptake and regulation in high-grade and lethal prostate cancers. PMID:28595267
MYC Deregulation in Primary Human Cancers. PMID:28587062
Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay. PMID:28586478
Next-generation Sequencing of Nonmuscle Invasive Bladder Cancer Reveals Potential Biomarkers and Rational Therapeutic Targets. PMID:28583311
Reduced Smad4 expression and DNA topoisomerase inhibitor chemosensitivity in non-small cell lung cancer. PMID:28577946
Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells. PMID:28576884
Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53. PMID:28574838
AACR Project GENIE: Powering Precision Medicine through an International Consortium. PMID:28572459
A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data. PMID:28569218
JUN-Mediated Downregulation of EGFR Signaling Is Associated with Resistance to Gefitinib in EGFR-mutant NSCLC Cell Lines. PMID:28566434
Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit. PMID:28564602
EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe? PMID:28561778
HDAC2 overexpression correlates with aggressive clinicopathological features and DNA-damage response pathway of breast cancer. PMID:28560068
FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells. PMID:28558758
Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice. PMID:28553932
Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines. PMID:28545079
Functional interaction between co-expressed MAGE-A proteins. PMID:28542476
Ezh2 Acts as a Tumor Suppressor in Kras-driven Lung Adenocarcinoma. PMID:28539837
Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors. PMID:28537878
The potential of organoids in urological cancer research. PMID:28534535
PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models. PMID:28532501
A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo. PMID:28530655
Genetic regulation of the RUNX transcription factor family has antitumor effects. PMID:28530640
A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations. PMID:28528867
Induction of senescence in primary glioblastoma cells by serum and TGFβ. PMID:28526854
XLF-mediated NHEJ activity in hepatocellular carcinoma therapy resistance. PMID:28526069
Targeted sequencing-based analyses of candidate gene variants in ulcerative colitis-associated colorectal neoplasia. PMID:28524162
Analyses of publicly available genomics resources define FGF-2-expressing bladder carcinomas as EMT-prone, proliferative tumors with low mutation rates and high expression of CTLA-4, PD-1 and PD-L1. PMID:28515962
Nicotinamide metabolism regulates glioblastoma stem cell maintenance. PMID:28515364
Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten-Deficient Mouse Model of Prostate Carcinogenesis. PMID:28515147
Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations. PMID:28515055
Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer. PMID:28512244
Focus on cutaneous and uveal melanoma specificities. PMID:28512236
Long Non-Coding RNA SNHG6 as a Potential Biomarker for Hepatocellular Carcinoma. PMID:28508329
Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling. PMID:28507813
Pro-necrotic molecules impact local immunosurveillance in human breast cancer. PMID:28507808
Preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma. PMID:28507806
Formyl peptide receptor 1 suppresses gastric cancer angiogenesis and growth by exploiting inflammation resolution pathways. PMID:28507800
Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity. PMID:28504970
Fibulin-3 promotes muscle-invasive bladder cancer. PMID:28504717
Cytoplasmic translocation of MTA1 coregulator promotes de-repression of SGK1 transcription in hypoxic cancer cells. PMID:28504714
Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer. PMID:28504713
Expression and alternative splicing of the cyclin-dependent kinase inhibitor-3 gene in human cancer. PMID:28504190
Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR. PMID:28499833
A novel microRNA regulator of prostate cancer epithelial-mesenchymal transition. PMID:28498363
RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma. PMID:28497782
Next-Generation Sequencing-based genomic profiling of brain metastases of primary ovarian cancer identifies high number of BRCA-mutations. PMID:28497333
AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer. PMID:28494797
Progression inference for somatic mutations in cancer. PMID:28492066
Identification of Long Noncoding RNAs Deregulated in Papillary Thyroid Cancer and Correlated with BRAFV600E Mutation by Bioinformatics Integrative Analysis. PMID:28490781
Recurrent promoter mutations in melanoma are defined by an extended context-specific mutational signature. PMID:28489852
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection. PMID:28489074
HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer. PMID:28487443
Genetic landscape of clear cell endometrial cancer and the era of precision medicine. PMID:28485840
TWIST1-WDR5-Hottip Regulates Hoxa9 Chromatin to Facilitate Prostate Cancer Metastasis. PMID:28484075
The zinc-finger transcriptional factor Slug transcriptionally downregulates ERα by recruiting lysine-specific demethylase 1 in human breast cancer. PMID:28481366
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. PMID:28481359
Secondary Use and Analysis of Big Data Collected for Patient Care. PMID:28480474
Association of body mass index with ER, PR and 14-3-3σ expression in tumor and stroma of type I and type II endometrial carcinoma. PMID:28476021
Heteroplasmic shifts in tumor mitochondrial genomes reveal tissue-specific signals of relaxed and positive selection. PMID:28475717
Clinical value of R-spondins in triple-negative and metaplastic breast cancers. PMID:28472820
Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma. PMID:28472509
MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets. PMID:28472340
In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma. PMID:28467784
Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition. PMID:28462496
Sirtuin 2 mutations in human cancers impair its function in genome maintenance. PMID:28461331
Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling. PMID:28460443
Oncogenic KRAS-associated gene signature defines co-targeting of CDK4/6 and MEK as a viable therapeutic strategy in colorectal cancer. PMID:28459468
Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells. PMID:28459464
Impaired AMPK Activity Drives Age-Associated Acute Lung Injury after Hemorrhage. PMID:28459384
Methods, Tools and Current Perspectives in Proteogenomics. PMID:28456751
TrkC promotes colorectal cancer growth and metastasis. PMID:28455963
A PanorOmic view of personal cancer genomes. PMID:28453651
Epigenetic dysregulation of ID4 predicts disease progression and treatment outcome in myeloid malignancies. PMID:28452111
Perturbation of DROSHA and DICER expression by human papillomavirus 16 oncoproteins. PMID:28448850
Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family. PMID:28446596
Mining Exosomal Genes for Pancreatic Cancer Targets. PMID:28446531
PathOS: a decision support system for reporting high throughput sequencing of cancers in clinical diagnostic laboratories. PMID:28438193
Synthesizer: Expediting synthesis studies from context-free data with information retrieval techniques. PMID:28437440
Lkb1 deletion in murine B lymphocytes promotes cell death and cancer. PMID:28435024
A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks. PMID:28432356
Characterization of Aurora A and Its Impact on the Effect of Cisplatin-Based Chemotherapy in Patients with Non-Small Cell Lung Cancer. PMID:28431392
SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway. PMID:28429243
High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors. PMID:28426873
Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples. PMID:28426665
Integrative epigenetic and genetic pan-cancer somatic alteration portraits. PMID:28426276
Oncogenic features of neuromedin U in breast cancer are associated with NMUR2 expression involving crosstalk with members of the WNT signaling pathway. PMID:28423716
A functional variant at the miRNA binding site in HMGB1 gene is associated with risk of oral squamous cell carcinoma. PMID:28423715
Systematic analysis of gene expression alterations and clinical outcomes of adenylate cyclase-associated protein in cancer. PMID:28423713
Genome-wide DNA methylation analysis reveals molecular subtypes of pancreatic cancer. PMID:28423671
Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer. PMID:28423402
The transcriptional STAT3 is a potential target, whereas transcriptional STAT5A/5B/6 are new biomarkers for prognosis in human breast carcinoma. PMID:28422733
The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness. PMID:28419090
Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface. PMID:28416796
Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication. PMID:28416140
Identification of long non-coding RNAs that stimulate cell survival in bladder cancer. PMID:28415801
Detection of COPB2 as a KRAS synthetic lethal partner through integration of functional genomics screens. PMID:28415695
The combined effect of USP7 inhibitors and PARP inhibitors in hormone-sensitive and castration-resistant prostate cancer cells. PMID:28415632
NaviCom: a web application to create interactive molecular network portraits using multi-level omics data. PMID:28415074
The role of GLI1 for 5-Fu resistance in colorectal cancer. PMID:28413604
Whole-Genome Sequence of the Metastatic PC3 and LNCaP Human Prostate Cancer Cell Lines. PMID:28413162
Development of a novel prognostic signature of long non-coding RNAs in lung adenocarcinoma. PMID:28409273
MMP11 and CD2 as novel prognostic factors in hormone receptor-negative, HER2-positive breast cancer. PMID:28409241
Gene Network Reconstruction using Global-Local Shrinkage Priors. PMID:28408966
The immune molecular landscape of the B7 and TNFR immunoregulatory ligand-receptor families in head and neck cancer: A comprehensive overview and the immunotherapeutic implications. PMID:28405520
NUSAP1 promotes invasion and metastasis of prostate cancer. PMID:28404898
IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing. PMID:28403884
IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis. PMID:28399871
Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma. PMID:28398584
A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC). PMID:28397687
Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. PMID:28396511
Metastasis-associated protein 1 is an upstream regulator of DNMT3a and stimulator of insulin-growth factor binding protein-3 in breast cancer. PMID:28393842
Cadherins Associate with Distinct Stem Cell-Related Transcription Factors to Coordinate the Maintenance of Stemness in Triple-Negative Breast Cancer. PMID:28392805
The tumor suppressor interferon regulatory factor 8 inhibits β-catenin signaling in breast cancers, but is frequently silenced by promoter methylation. PMID:28388578
Novel miRNA-mRNA interactions conserved in essential cancer pathways. PMID:28387377
Multinuclear NMR and MRI Reveal an Early Metabolic Response to mTOR Inhibition in Sarcoma. PMID:28386017
Nuclear survivin promoted by acetylation is associated with the aggressive phenotype of oral squamous cell carcinoma. PMID:28384094
Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade. PMID:28382931
HER2-Overexpressing Breast Cancers Amplify FGFR Signaling upon Acquisition of Resistance to Dual Therapeutic Blockade of HER2. PMID:28381415
Comparative study of joint bioinformatics analysis of underlying potential of 'neurimmiR', miR-212-3P/miR-132-3P, being involved in epilepsy and its emerging role in human cancer. PMID:28380454
Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival. PMID:28380429
DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing. PMID:28380355
Phase Ib/II Study of the Safety and Efficacy of Combination Therapy with Multikinase VEGF Inhibitor Pazopanib and MEK Inhibitor Trametinib In Advanced Soft Tissue Sarcoma. PMID:28377484
The Evolving Role of the Estrogen Receptor Mutations in Endocrine Therapy-Resistant Breast Cancer. PMID:28374222
The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway. PMID:28372542
The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters. PMID:28369554
Sox2 is dispensable for primary melanoma and metastasis formation. PMID:28368416
HBEGF promotes gliomagenesis in the context of Ink4a/Arf and Pten loss. PMID:28368403
Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer. PMID:28368395
Combinatorial Ranking of Gene Sets to Predict Disease Relapse: The Retinoic Acid Pathway in Early Prostate Cancer. PMID:28361034
Jmjd6, a JmjC Dioxygenase with Many Interaction Partners and Pleiotropic Functions. PMID:28360925
Safety and utility of image-guided research biopsies in relapsed high-grade serous ovarian carcinoma-experience of the BriTROC consortium. PMID:28359078
Identification of a Novel Somatic Mutation Leading to Allele Dropout for EGFR L858R Genotyping in Non-Small Cell Lung Cancer. PMID:28357677
Differential molecular regulation of processing and membrane expression of Type-I BMP receptors: implications for signaling. PMID:28357470
Diagnostic and prognostic roles of IRAK1 in hepatocellular carcinoma tissues: an analysis of immunohistochemistry and RNA-sequencing data from the cancer genome atlas. PMID:28356759
Racial Differences in Expression Levels of miRNA Machinery-Related Genes, Dicer, Drosha, DGCR8, and AGO2, in Asian Korean Papillary Thyroid Carcinoma and Comparative Validation Using the Cancer Genome Atlas. PMID:28352639
Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing. PMID:28350094
SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer. PMID:28346421
Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer. PMID:28344890
Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity. PMID:28344883
PI3K signaling in cancer: beyond AKT. PMID:28343126
Lipid quantification by Raman microspectroscopy as a potential biomarker in prostate cancer. PMID:28342983
Next-generation sequencing of urine specimens: A novel platform for genomic analysis in patients with non-muscle-invasive urothelial carcinoma treated with bacille Calmette-Guérin. PMID:28339163
Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer. PMID:28338653
Integrative analysis of multi-omics data reveals distinct impacts of DDB1-CUL4 associated factors in human lung adenocarcinomas. PMID:28336923
NELF-E is recruited to DNA double-strand break sites to promote transcriptional repression and repair. PMID:28336775
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies. PMID:28336552
CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion. PMID:28334900
PathwayMapper: a collaborative visual web editor for cancer pathways and genomic data. PMID:28334343
Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs. PMID:28333136
PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4. PMID:28332630
The Role of PIAS SUMO E3-Ligases in Cancer. PMID:28330929
Orchestrating differential data access for translational research: a pilot implementation. PMID:28330491
Regulation of ITGA3 by the dual-stranded microRNA-199 family as a potential prognostic marker in bladder cancer. PMID:28324890
The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia. PMID:28321123
FOXA1 inhibits prostate cancer neuroendocrine differentiation. PMID:28319070
Towards precision oncology in RET-aberrant cancers. PMID:28318386
Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation. PMID:28317937
Distinct ErbB2 receptor populations differentially interact with beta1 integrin in breast cancer cell models. PMID:28306722
TRAF3/CYLD mutations identify a distinct subset of human papillomavirus-associated head and neck squamous cell carcinoma. PMID:28295222
Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer. PMID:28294470
Comprehensive discovery of subsample gene expression components by information explanation: therapeutic implications in cancer. PMID:28292312
Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer. PMID:28290516
AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins. PMID:28287129
A Review of mTOR Pathway Inhibitors in Gynecologic Cancer. PMID:28286604
BRAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumorigenesis. PMID:28281325
Marked for death: targeting epigenetic changes in cancer. PMID:28280262
Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer. PMID:28267766
Precision medicine driven by cancer systems biology. PMID:28265786
Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells. PMID:28264911
Piccolo mediates EGFR signaling and acts as a prognostic biomarker in esophageal squamous cell carcinoma. PMID:28263981
Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer. PMID:28263970
Surveilling the Potential for Precision Medicine-driven PD-1/PD-L1-targeted Therapy in HNSCC. PMID:28261333
A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism. PMID:28257692
HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors. PMID:28255362
Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity. PMID:28255353
A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis. PMID:28253859
Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. PMID:28249155
ZEB1 regulates glioma stemness through LIF repression. PMID:28246407
Androgen Receptor Signaling in Bladder Cancer. PMID:28241422
Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer. PMID:28235401
PIK3CA-mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation. PMID:28233937
Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17. PMID:28232483
Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma. PMID:28228279
Molecular Testing for Gastrointestinal Cancer. PMID:28219002
Mcm10: A Dynamic Scaffold at Eukaryotic Replication Forks. PMID:28218679
Amphiregulin as a Novel Serum Marker of Puberty in Girls. PMID:28216130
Role of a p53 polymorphism in the development of nonfunctional pituitary adenomas. PMID:28214592
High PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 function. PMID:28213783
Emerging themes of regulation at the Golgi. PMID:28213314
Genetic characterization of Polish ccRCC patients: somatic mutation analysis of PBRM1, BAP1 and KDMC5, genomic SNP array analysis in tumor biopsy and preliminary results of chromosome aberrations analysis in plasma cell free DNA. PMID:28212566
PLCB4 copy gain and PLCß4 overexpression in primary gastrointestinal stromal tumors: Integrative characterization of a lipid-catabolizing enzyme associated with worse disease-free survival. PMID:28212550
The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. PMID:28211885
OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. PMID:28209616
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies. PMID:28205554
Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway. PMID:28202526
Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma. PMID:28202515
Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas. PMID:28201779
ELF3 is a negative regulator of epithelial-mesenchymal transition in ovarian cancer cells. PMID:28199976
Molecular Mutations and Their Cooccurrences in Cytogenetically Normal Acute Myeloid Leukemia. PMID:28197208
MiR-143 Targeting TAK1 Attenuates Pancreatic Ductal Adenocarcinoma Progression via MAPK and NF-κB Pathway In Vitro. PMID:28194669
Real-time genomic profiling of histiocytoses identifies early-kinase domain BRAF alterations while improving treatment outcomes. PMID:28194436
Circulating and tissue biomarkers in early-stage non-small cell lung cancer. PMID:28194229
Annotating Mutational Effects on Proteins and Protein Interactions: Designing Novel and Revisiting Existing Protocols. PMID:28188534
Upregulation of FAM84B during prostate cancer progression. PMID:28186973
Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and PIK3CA Mutations. PMID:28184015
ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib. PMID:28182994
KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1. PMID:28180290
Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer. PMID:28178648
Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. PMID:28177281
LncRNA AK023948 is a positive regulator of AKT. PMID:28176758
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. PMID:28174173
A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer. PMID:28169991
Physical and Functional Interactions between ELL2 and RB in the Suppression of Prostate Cancer Cell Proliferation, Migration, and Invasion. PMID:28167296
Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma. PMID:28162975
SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation. PMID:28159833
Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia. PMID:28153030
Clinical significance and effect of AEG-1 on the proliferation, invasion, and migration of NSCLC: a study based on immunohistochemistry, TCGA, bioinformatics, in vitro and in vivo verification. PMID:28152520
microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis through revival of TWIST1 in renal cell carcinoma. PMID:28152509
Prediction of Protein Interactions by Structural Matching: Prediction of PPI Networks and the Effects of Mutations on PPIs that Combines Sequence and Structural Information. PMID:28150242
Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer. PMID:28148288
Keratin 5 overexpression is associated with serous ovarian cancer recurrence and chemotherapy resistance. PMID:28147318
MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy. PMID:28146422
KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. PMID:28145866
Synchronous Bilateral Breast Cancer in a Patient With Nager Syndrome. PMID:28139434
The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation. PMID:28137908
E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling. PMID:28137882
Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice. PMID:28134936
Uncovering the role of USP54 in cancer. PMID:28129647
Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors. PMID:28126323
Clinical and Morphologic Features of ETV6-NTRK3 Translocated Papillary Thyroid Carcinoma in an Adult Population Without Radiation Exposure. PMID:28125451
CXCR4-CXCL12-CXCR7, TLR2-TLR4, and PD-1/PD-L1 in colorectal cancer liver metastases from neoadjuvant-treated patients. PMID:28123896
Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk. PMID:28123876
Genome-wide DNA copy number analysis in clonally expanded human ovarian cancer cells with distinct invasive/migratory capacities. PMID:28122348
Genome-wide screen identifies a novel prognostic signature for breast cancer survival. PMID:28122328
Combined evaluation of the FAS cell surface death receptor and CD8+ tumor infiltrating lymphocytes as a prognostic biomarker in breast cancer. PMID:28121628
Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity. PMID:28117753
3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets. PMID:28115009
Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL. PMID:28114281
The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma. PMID:28114277
Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma. PMID:28108737
Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1. PMID:28108589
SDHD Promoter Mutations Ablate GABP Transcription Factor Binding in Melanoma. PMID:28108517
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA. PMID:28106072
Ubiquitin specific protease 21 upregulation in breast cancer promotes cell tumorigenic capability and is associated with the NOD-like receptor signaling pathway. PMID:28105162
WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer. PMID:28102297
Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. PMID:28101337
Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions. PMID:28100566
Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma. PMID:28099935
The EMSY threonine 207 phospho-site is required for EMSYdriven suppression of DNA damage repair. PMID:28099152
Metastasis regulation by PPARD expression in cancer cells. PMID:28097239
β-Catenin haploinsufficiency promotes mammary tumorigenesis in an ErbB2-positive basal breast cancer model. PMID:28096336
The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma. PMID:28096290
Order Matters: The Order of Somatic Mutations Influences Cancer Evolution. PMID:28096247
Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma. PMID:28096186
Entropy Transfer between Residue Pairs and Allostery in Proteins: Quantifying Allosteric Communication in Ubiquitin. PMID:28095404
Iron overload and altered iron metabolism in ovarian cancer. PMID:28095368
SPAG6 and L1TD1 are transcriptionally regulated by DNA methylation in non-small cell lung cancers. PMID:28093071
Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality. PMID:28092670
Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase. PMID:28090586
ROS1 Fusions Rarely Overlap with Other Oncogenic Drivers in Non-Small Cell Lung Cancer. PMID:28088512
A transcriptome profile in hepatocellular carcinomas based on integrated analysis of microarray studies. PMID:28086821
Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3. PMID:28085101
Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma. PMID:28084339
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma. PMID:28082722
TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation. PMID:28082682
FAM83 family oncogenes are broadly involved in human cancers: an integrative multi-omics approach. PMID:28078827
HDAC10 as a potential therapeutic target in ovarian cancer. PMID:28073598
A Survey of Computational Tools to Analyze and Interpret Whole Exome Sequencing Data. PMID:28070503
APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. PMID:28069571
TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation. PMID:28068325
SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. PMID:28067909
The NF1 gene in tumor syndromes and melanoma. PMID:28067895
Computational polypharmacology: a new paradigm for drug discovery. PMID:28067061
Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients. PMID:28061480
Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions. PMID:28057438
Integrative genomic and transcriptomic analysis for pinpointing recurrent alterations of plant homeodomain genes and their clinical significance in breast cancer. PMID:28055972
Genomic analysis of exceptional responders to radiotherapy reveals somatic mutations in ATM. PMID:28055970
Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer. PMID:28055301
Expression of T-Lymphocyte Markers in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer. PMID:28053626
PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion. PMID:28051998
The Role of Aneuploidy in Cancer Evolution. PMID:28049655
TCGA2BED: extracting, extending, integrating, and querying The Cancer Genome Atlas. PMID:28049410
Using knowledge-driven genomic interactions for multi-omics data analysis: metadimensional models for predicting clinical outcomes in ovarian carcinoma. PMID:28040685
Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival. PMID:28039471
Key Survival Factor, Mcl-1, Correlates with Sensitivity to Combined Bcl-2/Bcl-xL Blockade. PMID:28039357
Elucidation of the genetic and epigenetic landscape alterations in RNA binding proteins in glioblastoma. PMID:28035070
GlioVis data portal for visualization and analysis of brain tumor expression datasets. PMID:28031383
ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. PMID:28031255
The role of prostate tumor overexpressed 1 in cancer progression. PMID:28029646
SNP variants at the MAP3K1/SETD9 locus 5q11.2 associate with somatic PIK3CA variants in breast cancers. PMID:28029147
Genomic Analysis of Uterine Lavage Fluid Detects Early Endometrial Cancers and Reveals a Prevalent Landscape of Driver Mutations in Women without Histopathologic Evidence of Cancer: A Prospective Cross-Sectional Study. PMID:28027320
Defining the boundaries and expanding the utility of head and neck cancer patient derived xenografts. PMID:28024726
The Mutational Landscape of the Oncogenic MZF1 SCAN Domain in Cancer. PMID:28018905
Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53. PMID:28008906
Chemoresistance and targeted therapies in ovarian and endometrial cancers. PMID:28008141
Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations. PMID:28007021
The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism. PMID:28003335
The Heat Shock Transcription Factor HSF1 Induces Ovarian Cancer Epithelial-Mesenchymal Transition in a 3D Spheroid Growth Model. PMID:27997575
Nucleophosmin Mutations Induce Chemosensitivity in THP-1 Leukemia Cells by Suppressing NF-κB Activity and Regulating Bax/Bcl-2 Expression. PMID:27994664
Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival. PMID:27994142
A novel NFIA-NFκB feed-forward loop contributes to glioblastoma cell survival. PMID:27994064
Flexible model-based clustering of mixed binary and continuous data: application to genetic regulation and cancer. PMID:27994031
Circulating cell-free DNA-based epigenetic assay can detect early breast cancer. PMID:27993161
Senescence marker protein 30 (SMP30) serves as a potential prognostic indicator in hepatocellular carcinoma. PMID:27991558
A CRISPR/Cas9 Functional Screen Identifies Rare Tumor Suppressors. PMID:27982060
Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology-molecular associations: clinical and biological implications. PMID:27982025
Comprehensive analysis of the long noncoding RNA HOXA11-AS gene interaction regulatory network in NSCLC cells. PMID:27980454
Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase. PMID:27979310
Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression. PMID:27977328
Targeting metastasis-initiating cells through the fatty acid receptor CD36. PMID:27974793
Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers. PMID:27974415
Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism. PMID:27966532
ERK-mediated NF-κB activation through ASIC1 in response to acidosis. PMID:27941930
The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination. PMID:27941881
NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors? PMID:27938406
Large-Scale Analysis of Gene Expression Data Reveals a Novel Gene Expression Signature Associated with Colorectal Cancer Distant Recurrence. PMID:27935967
A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth. PMID:27935819
CASP9 germline mutation in a family with multiple brain tumors. PMID:27935156
Profiling lung adenocarcinoma by liquid biopsy: can one size fit all? PMID:27933110
MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib. PMID:27931239
Gene expression and pathway analysis of CTNNB1 in cancer and stem cells. PMID:27928465
ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin. PMID:27923832
Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases. PMID:27923045
Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine. PMID:27923043
Maximising the potential of AKT inhibitors as anti-cancer treatments. PMID:27919797
Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy. PMID:27918595
GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer. PMID:27918237
Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer. PMID:27916600
Y-box binding protein-1 promotes hepatocellular carcinoma-initiating cell progression and tumorigenesis via Wnt/β-catenin pathway. PMID:27911878
L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling. PMID:27910855
The implication of FLT3 amplification for FLT targeted therapeutics in solid tumors. PMID:27906677
Tumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour. PMID:27906134
LncRNAs are altered in lung squamous cell carcinoma and lung adenocarcinoma. PMID:27903974
MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma. PMID:27903915
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations. PMID:27903500
Intrinsic HER2 V777L mutation mediates resistance to trastuzumab in a breast cancer patient. PMID:27900589
Aberrations in the Iron Regulatory Gene Signature Are Associated with Decreased Survival in Diffuse Infiltrating Gliomas. PMID:27898674
Functional exploration of colorectal cancer genomes using Drosophila. PMID:27897178
MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer. PMID:27893706
TFAP2C-mediated upregulation of TGFBR1 promotes lung tumorigenesis and epithelial-mesenchymal transition. PMID:27885255
Rs3842530 Polymorphism in MicroRNA-205 Host Gene in Lung and Breast Cancer Patients. PMID:27885248
CpG Island Methylator Phenotype-High Colorectal Cancers and Their Prognostic Implications and Relationships with the Serrated Neoplasia Pathway. PMID:27885175
Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis. PMID:27884605
Patterns of ribosomal protein expression specify normal and malignant human cells. PMID:27884178
Institutional implementation of clinical tumor profiling on an unselected cancer population. PMID:27882345
SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis. PMID:27880766
Deletion of 8p is an independent prognostic parameter in prostate cancer. PMID:27880722
Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors. PMID:27875628
Clinical and genetic determinants of ovarian metastases from colorectal cancer. PMID:27875625
Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. PMID:27870829
Inactivation of Capicua drives cancer metastasis. PMID:27869830
Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets. PMID:27866910
A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease. PMID:27863505
Deletion of 18q is a strong and independent prognostic feature in prostate cancer. PMID:27861151
Head and neck squamous cell carcinoma: Ambiguous human papillomavirus status, elevated p16, and deleted retinoblastoma 1. PMID:27859938
High-throughput sequencing of two populations of extracellular vesicles provides an mRNA signature that can be detected in the circulation of breast cancer patients. PMID:27858503
GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis. PMID:27856536
p15 Expression Differentiates Nevus from Melanoma. PMID:27855847
Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer. PMID:27855669
IGFBP2 expression predicts IDH-mutant glioma patient survival. PMID:27852048
IAP antagonists induce anti-tumor immunity in multiple myeloma. PMID:27841872
Neomorphic mutations create therapeutic challenges in cancer. PMID:27841866
Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors. PMID:27837027
Combination of COX-2 expression and PIK3CA mutation as prognostic and predictive markers for celecoxib treatment in breast cancer. PMID:27835884
p16 overexpression and 9p21 deletion are linked to unfavorable tumor phenotype in breast cancer. PMID:27835607
Long intergenic non-coding RNA 271 is predictive of a poorer prognosis of papillary thyroid cancer. PMID:27833134
Adhesion GPCRs in Tumorigenesis. PMID:27832497
SUMOylated MAFB promotes colorectal cancer tumorigenesis. PMID:27829226
Amplification of MUC1 in prostate cancer metastasis and CRPC development. PMID:27825118
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer. PMID:27824159
Protease-activated receptor-1 inhibits proliferation but enhances leukemia stem cell activity in acute myeloid leukemia. PMID:27819671
The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. PMID:27819275
p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. PMID:27815262
Somatic cancer variant curation and harmonization through consensus minimum variant level data. PMID:27814769
Systematic approach identifies RHOA as a potential biomarker therapeutic target for Asian gastric cancer. PMID:27806312
Structural basis for DNA recognition by STAT6. PMID:27803324
A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. PMID:27799065
Phosphatidylinositol 4-kinase IIβ negatively regulates invadopodia formation and suppresses an invasive cellular phenotype. PMID:27798239
Serpin E2 promotes breast cancer metastasis by remodeling the tumor matrix and polarizing tumor associated macrophages. PMID:27793045
DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study. PMID:27793038
A Systems Biology Comparison of Ovarian Cancers Implicates Putative Somatic Driver Mutations through Protein-Protein Interaction Models. PMID:27788148
The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer. PMID:27783945
PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. PMID:27775705
G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion. PMID:27765922
Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants. PMID:27760319
TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions. PMID:27759562
Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation. PMID:27758883
Epigenetic determinants of metastasis. PMID:27756687
Using Pharmacogenomic Databases for Discovering Patient-Target Genes and Small Molecule Candidates to Cancer Therapy. PMID:27746730
Comprehensive Genetic Landscape of Uveal Melanoma by Whole-Genome Sequencing. PMID:27745836
Cohesin Mutations in Cancer. PMID:27742736
Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma. PMID:27738315
MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer. PMID:27731867
Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model. PMID:27729860
Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients. PMID:27729614
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer. PMID:27728805
Increased global transcription activity as a mechanism of replication stress in cancer. PMID:27725641
CCAR2 Is Required for Proliferation and Tumor Maintenance in Human Squamous Cell Carcinoma. PMID:27725203
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate. PMID:27723727
Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research. PMID:27713570
Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets. PMID:27713405
Upregulation of HSF1 in estrogen receptor positive breast cancer. PMID:27713164
Clinical Relevance and Molecular Phenotypes in Gastric Cancer, of TP53 Mutations and Gene Expressions, in Combination With Other Gene Mutations. PMID:27708434
APSA Awardee Submission: Tumor/cancer stem cell marker doublecortin-like kinase 1 in liver diseases. PMID:27694285
Predicting PD-L1 expression on human cancer cells using next-generation sequencing information in computational simulation models. PMID:27688163
Efficacy of poly (ADP-ribose) polymerase inhibitor olaparib against head and neck cancer cells: Predictions of drug sensitivity based on PAR-p53-NF-κB interactions. PMID:27686740
Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix. PMID:27683114
The possible roles of B-cell novel protein-1 (BCNP1) in cellular signalling pathways and in cancer. PMID:27680505
Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design. PMID:27672311
Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition. PMID:27663592
SEPT9 and SHOX2 DNA methylation status and its utility in the diagnosis of colonic adenomas and colorectal adenocarcinomas. PMID:27660666
Functional genetic variant in the Kozak sequence of WW domain-containing oxidoreductase (WWOX) gene is associated with oral cancer risk. PMID:27655721
Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer. PMID:27655714
Sex chromosome loss and the pseudoautosomal region genes in hematological malignancies. PMID:27655702
Anti-EGFR monoclonal antibodies and EGFR tyrosine kinase inhibitors as combination therapy for triple-negative breast cancer. PMID:27655662
A Meta-Analysis: Identification of Common Mir-145 Target Genes that have Similar Behavior in Different GEO Datasets. PMID:27655328
High-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation. PMID:27651363
WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines. PMID:27650553
SHP2 phosphatase as a novel therapeutic target for melanoma treatment. PMID:27650545
ZNF703 Overexpression may act as an oncogene in non-small cell lung cancer. PMID:27650486
Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma. PMID:27647909
Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors. PMID:27646943
Individual and Combined Expression of DNA Damage Response Molecules PARP1, γH2AX, BRCA1, and BRCA2 Predict Shorter Survival of Soft Tissue Sarcoma Patients. PMID:27643881
Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors. PMID:27643540
Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. PMID:27642788
Multi-omics approach to infer cancer therapeutic targets on chromosome 20q across tumor types. PMID:27642640
ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA. PMID:27641332
Beta-adrenergic signaling promotes tumor angiogenesis and prostate cancer progression through HDAC2-mediated suppression of thrombospondin-1. PMID:27641328
Alkylating Agent-Induced NRF2 Blocks Endoplasmic Reticulum Stress-Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis. PMID:27638861
Histone H3 lysine 23 acetylation is associated with oncogene TRIM24 expression and a poor prognosis in breast cancer. PMID:27638829
Tubulocystic Carcinoma of the Kidney With Poorly Differentiated Foci: A Frequent Morphologic Pattern of Fumarate Hydratase-deficient Renal Cell Carcinoma. PMID:27635946
A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice. PMID:27634876
Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin. PMID:27633757
Study of apoptosis-related interactions in colorectal cancer. PMID:27629291
IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives. PMID:27621679
Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate. PMID:27621311
Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33. PMID:27619158
The DNA Damage Transducer RNF8 Facilitates Cancer Chemoresistance and Progression through Twist Activation. PMID:27618486
Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype. PMID:27617860
Ecotropic viral integration site 1, a novel oncogene in prostate cancer. PMID:27617580
Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates epidermal growth factor receptor in prostate cancer. PMID:27611943
Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors. PMID:27611922
Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis. PMID:27610619
A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets. PMID:27609069
Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer. PMID:27604488
Pro-invasive Effect of Proto-oncogene PBF Is Modulated by an Interaction with Cortactin. PMID:27603901
Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer. PMID:27602502
Cytidine Deaminase Deficiency Reveals New Therapeutic Opportunities against Cancer. PMID:27601591
miR-564 acts as a dual inhibitor of PI3K and MAPK signaling networks and inhibits proliferation and invasion in breast cancer. PMID:27600857
Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer. PMID:27599661
Functional networks inference from rule-based machine learning models. PMID:27597880
Mutational load and mutational patterns in relation to age in head and neck cancer. PMID:27596625
Personalized characterization of diseases using sample-specific networks. PMID:27596597
ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors. PMID:27596438
Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. PMID:27590350
Dysregulation of TGFβ1 Activity in Cancer and Its Influence on the Quality of Anti-Tumor Immunity. PMID:27589814
Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity. PMID:27588951
Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma. PMID:27586084
Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase. PMID:27585847
Minireview: The Link Between ERα Corepressors and Histone Deacetylases in Tamoxifen Resistance in Breast Cancer. PMID:27581354
FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib. PMID:27581340
Nonhistone Lysine Methylation in the Regulation of Cancer Pathways. PMID:27580749
A PGC1α-mediated transcriptional axis suppresses melanoma metastasis. PMID:27580028
RNA2DNAlign: nucleotide resolution allele asymmetries through quantitative assessment of RNA and DNA paired sequencing data. PMID:27576531
Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors. PMID:27572108
RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation. PMID:27571409
Expression and clinicopathological implication of DcR3 in lung cancer tissues: a tissue microarray study with 365 cases. PMID:27570459
The CD47 "don't eat me signal" is highly expressed in human ovarian cancer. PMID:27569584
ZEB1 expression is increased in IDH1-mutant lower-grade gliomas. PMID:27568035
Expression of a novel endothelial marker, C-type lectin 14A, in epithelial ovarian cancer and its prognostic significance. PMID:27567920
Microarray-based identification of genes associated with cancer progression and prognosis in hepatocellular carcinoma. PMID:27567667
Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface. PMID:27563818
pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. PMID:27563096
Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53. PMID:27559130
A Synthetic Dosage Lethal Genetic Interaction Between CKS1B and PLK1 Is Conserved in Yeast and Human Cancer Cells. PMID:27558135
Identification of breast cancer cell subtypes sensitive to ATG4B inhibition. PMID:27556700
Genetic determinants in head and neck squamous cell carcinoma and their influence on global personalized medicine. PMID:27551333
Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. PMID:27551064
Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis. PMID:27546461
Activation of GRP/GRP-R signaling contributes to castration-resistant prostate cancer progression. PMID:27542219
The mutational spectrum of FOXA2 in endometrioid endometrial cancer points to a tumor suppressor role. PMID:27538367
The Non-coding Mammary Carcinoma Susceptibility Locus, Mcs5c, Regulates Pappa Expression via Age-Specific Chromatin Folding and Allele-Dependent DNA Methylation. PMID:27537370
Gene Coexpression Analyses Differentiate Networks Associated with Diverse Cancers Harboring TP53 Missense or Null Mutations. PMID:27536319
Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models. PMID:27535970
The biorepository portal toolkit: an honest brokered, modular service oriented software tool set for biospecimen-driven translational research. PMID:27535360
Mixed Mesonephric Adenocarcinoma and High-grade Neuroendocrine Carcinoma of the Uterine Cervix: Case Description of a Previously Unreported Entity With Insights Into Its Molecular Pathogenesis. PMID:27532149
Novel B55α-PP2A mutations in AML promote AKT T308 phosphorylation and sensitivity to AKT inhibitor-induced growth arrest. PMID:27531894
Clinical utility and treatment outcome of comprehensive genomic profiling in high grade glioma patients. PMID:27531351
Exploring cancer genomic data from the cancer genome atlas project. PMID:27530686
ExSurv: A Web Resource for Prognostic Analyses of Exons Across Human Cancers Using Clinical Transcriptomes. PMID:27528797
Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation. PMID:27528607
DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer. PMID:27520310
Dual Chromatin and Cytoskeletal Remodeling by SETD2. PMID:27518565
USP9X destabilizes pVHL and promotes cell proliferation. PMID:27517496
Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia. PMID:27510297
Integrated genomic analysis of recurrence-associated small non-coding RNAs in oesophageal cancer. PMID:27507904
EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer. PMID:27507850
HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma. PMID:27506904
Databases and tools for constructing signal transduction networks in cancer. PMID:27502015
Cancer Clocks Out for Lunch: Disruption of Circadian Rhythm and Metabolic Oscillation in Cancer. PMID:27500134
In-depth molecular profiling of the biphasic components of uterine carcinosarcomas. PMID:27499902
Differential expression of argininosuccinate synthetase in serous and non-serous ovarian carcinomas. PMID:27499892
High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML. PMID:27498870
Epigenetic activation of LY6K predicts the presence of metastasis and poor prognosis in breast carcinoma. PMID:27494879
Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers. PMID:27494611
The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts. PMID:27494403
Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development. PMID:27494029
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth. PMID:27492255
Lollipops in the Clinic: Information Dense Mutation Plots for Precision Medicine. PMID:27490490
Significance of BMI1 and FSCN1 expression in colorectal cancer. PMID:27488323
The microRNA signature of patients with sunitinib failure: regulation of UHRF1 pathways by microRNA-101 in renal cell carcinoma. PMID:27487138
Ubc13: the Lys63 ubiquitin chain building machine. PMID:27486774
Mammary epithelial morphogenesis and early breast cancer. Evidence of involvement of basal components of the RNA Polymerase I transcription machinery. PMID:27485818
PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs). PMID:27481946
Clinical Genomics: Challenges and Opportunities. PMID:27480773
Genomic characterization of response to chemoradiation in urothelial bladder cancer. PMID:27479538
Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth. PMID:27477273
c-CBL regulates melanoma proliferation, migration, invasion and the FAK-SRC-GRB2 nexus. PMID:27472394
SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2. PMID:27469115
Loss of Dickkopf 3 Promotes the Tumorigenesis of Basal Breast Cancer. PMID:27467270
Metastatic risk and resistance to BRAF inhibitors in melanoma defined by selective allelic loss of ATG5. PMID:27464255
A multifaceted computational report on the variants effect on KIR2DL3 and IFNL3 candidate gene in HCV clearance. PMID:27461217
Vitamin D Deficiency Promotes Liver Tumor Growth in Transforming Growth Factor-β/Smad3-Deficient Mice Through Wnt and Toll-like Receptor 7 Pathway Modulation. PMID:27456065
A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy. PMID:27453043
PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition. PMID:27451907
Clinical Outcomes of TP53 Mutations in Cancers. PMID:27449973
Aberrant expression and functions of protocadherins in human malignant tumors. PMID:27449047
Prognostic relevance of autophagy-related markers LC3, p62/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status. PMID:27444698
Case report of a Li-Fraumeni syndrome-like phenotype with a de novo mutation in CHEK2. PMID:27442652
Integration and Visualization of Translational Medicine Data for Better Understanding of Human Diseases. PMID:27441714
Integrating Heterogeneous Biomedical Data for Cancer Research: the CARPEM infrastructure. PMID:27437039
Examination of CK2α and NF-κB p65 expression in human benign prostatic hyperplasia and prostate cancer tissues. PMID:27435858
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma. PMID:27433843
Cardiac glycosides display selective efficacy for STK11 mutant lung cancer. PMID:27431571
Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation. PMID:27431380
Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations. PMID:27428513
Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer. PMID:27428427
Phenotypic plasticity in prostate cancer: role of intrinsically disordered proteins. PMID:27427552
TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects. PMID:27425591
The role of wild type RAS isoforms in cancer. PMID:27422332
MET amplification in metastatic colorectal cancer: an acquired response to EGFR inhibition, not a de novo phenomenon. PMID:27421137
A novel gene expression-based prognostic scoring system to predict survival in gastric cancer. PMID:27419373
A germline ERBB3 variant is a candidate for predisposition to erythroid MDS/erythroleukemia. PMID:27416908
Regulation and function of AMPK in physiology and diseases. PMID:27416781
The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer. PMID:27413115
Myotubularin-related protein 7 inhibits insulin signaling in colorectal cancer. PMID:27409167
A comprehensive next generation sequencing-based virome assessment in brain tissue suggests no major virus - tumor association. PMID:27402152
NFAT1 transcription factor regulates cell cycle progression and cyclin E expression in B lymphocytes. PMID:27399331
Causes and consequences of nuclear envelope alterations in tumour progression. PMID:27397692
Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. PMID:27393618
Non-myogenic tumors display altered expression of dystrophin (DMD) and a high frequency of genetic alterations. PMID:27391342
MET Inhibition in Clear Cell Renal Cell Carcinoma. PMID:27390595
TMPRSS4 induces invasion and proliferation of prostate cancer cells through induction of Slug and cyclin D1. PMID:27385093
Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3-MYC Interactions as a Target in Pancreatic Cancer. PMID:27384421
RAB25 expression is epigenetically downregulated in oral and oropharyngeal squamous cell carcinoma with lymph node metastasis. PMID:27379752
Computational genomics tools for dissecting tumour-immune cell interactions. PMID:27376489
Co-Expression Network Analysis of Fbxw7-Associated LncRNAs Reveals Their Functions in Radiation-Induced Thymic Lymphoma. PMID:27376155
BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. PMID:27373334
HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment. PMID:27370607
Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma. PMID:27370399
Combined genetic and epigenetic interferences with interferon signaling expose prostate cancer cells to viral infection. PMID:27366948
Transcriptomic reappraisal identifies MGLL overexpression as an unfavorable prognosticator in primary gastrointestinal stromal tumors. PMID:27366945
Deep Genetic Connection Between Cancer and Developmental Disorders. PMID:27363847
Dynein axonemal heavy chain 8 promotes androgen receptor activity and associates with prostate cancer progression. PMID:27363033
Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma. PMID:27363021
CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. PMID:27358011
Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. PMID:27357947
Sterol Regulatory Element Binding Protein Regulates the Expression and Metabolic Functions of Wild-Type and Oncogenic IDH1. PMID:27354064
Silencing of ZRF1 impedes survival of estrogen receptor positive MCF-7 cells and potentiates the effect of curcumin. PMID:27350366
MonoSeq Variant Caller Reveals Novel Mononucleotide Run Indel Mutations in Tumors with Defective DNA Mismatch Repair. PMID:27346418
FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis. PMID:27346356
Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome. PMID:27340778
Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer. PMID:27340777
Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma. PMID:27333051
MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis. PMID:27330189
Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma. PMID:27329590
Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End. PMID:27329033
PRAME expression and promoter hypomethylation in epithelial ovarian cancer. PMID:27322684
Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer. PMID:27322458
Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3. PMID:27319316
GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis. PMID:27312530
p85α neomorphic mutants: splitting away from the canonical path. PMID:27308516
PrimPol-A new polymerase on the block. PMID:27308331
Frequent PIK3CA Mutations in Colorectal and Endometrial Tumors With 2 or More Somatic Mutations in Mismatch Repair Genes. PMID:27302833
Tumor and Plasma Met Levels in Non-Metastatic Prostate Cancer. PMID:27300295
Upregulation of AKT3 Confers Resistance to the AKT Inhibitor MK2206 in Breast Cancer. PMID:27297869
Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth. PMID:27292643
Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma. PMID:27287018
Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1. PMID:27286452
WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck. PMID:27285764
A microscopic landscape of the invasive breast cancer genome. PMID:27283966
Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo. PMID:27283899
Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator. PMID:27282385
Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3. PMID:27281824
Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis. PMID:27281560
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor. PMID:27279227
NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-κB pathway. PMID:27270613
Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response. PMID:27270441
Myeloid translocation genes differentially regulate colorectal cancer programs. PMID:27270437
KCNN4 and S100A14 act as predictors of recurrence in optimally debulked patients with serous ovarian cancer. PMID:27270322
Clonal evolution of glioblastoma under therapy. PMID:27270107
Autophagy gene expression profiling identifies a defective microtubule-associated protein light chain 3A mutant in cancer. PMID:27256984
Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned. PMID:27255914
Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice. PMID:27255182
Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2α Kinase Levels in NRAS(Q61) Mutant Cells. PMID:27251789
Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis. PMID:27248819
Recurrent, truncating SOX9 mutations are associated with SOX9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma. PMID:27248473
Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism. PMID:27248322
Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells. PMID:27246979
Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers. PMID:27244218
Engineered Swine Models of Cancer. PMID:27242889
Genomic Characterization of High-Grade Serous Ovarian Cancer: Dissecting Its Molecular Heterogeneity as a Road Towards Effective Therapeutic Strategies. PMID:27241520
Functional/activity network (FAN) analysis of gene-phenotype connectivity liaised by grape polyphenol resveratrol. PMID:27232943
The lncRNA PVT1 Contributes to the Cervical Cancer Phenotype and Associates with Poor Patient Prognosis. PMID:27232880
Connexin and pannexin channels in cancer. PMID:27229305
Serpin peptidase inhibitor (SERPINB5) haplotypes are associated with susceptibility to hepatocellular carcinoma. PMID:27221742
Reduced SOD2 expression is associated with mortality of hepatocellular carcinoma patients in a mutant p53-dependent manner. PMID:27221200
FAM83 proteins: Fostering new interactions to drive oncogenic signaling and therapeutic resistance. PMID:27221039
Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer. PMID:27220963
Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles. PMID:27220849
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis. PMID:27219062
The metabolic co-regulator PGC1α suppresses prostate cancer metastasis. PMID:27214280
REC8 functions as a tumor suppressor and is epigenetically downregulated in gastric cancer, especially in EBV-positive subtype. PMID:27212034
Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer. PMID:27205883
Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. PMID:27203177
Pan-cancer analyses of the nuclear receptor superfamily. PMID:27200367
Reconstruction of gene regulatory networks reveals chromatin remodelers and key transcription factors in tumorigenesis. PMID:27198694
Increased Expression of miR-23a Mediates a Loss of Expression in the RAF Kinase Inhibitor Protein RKIP. PMID:27197200
Infiltrating T Cells Promote Bladder Cancer Progression via Increasing IL1→Androgen Receptor→HIF1α→VEGFa Signals. PMID:27196763
Validation of Novel Biomarkers for Prostate Cancer Progression by the Combination of Bioinformatics, Clinical and Functional Studies. PMID:27196083
Practical aspects of NGS-based pathways analysis for personalized cancer science and medicine. PMID:27191992
GRK3 is a direct target of CREB activation and regulates neuroendocrine differentiation of prostate cancer cells. PMID:27191986
SETD2: an epigenetic modifier with tumor suppressor functionality. PMID:27191891
Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) interacts with estrogen receptor and predicted poor survival in breast cancer. PMID:27191888
Anti-tumor efficacy of BEZ235 is complemented by its anti-angiogenic effects via downregulation of PI3K-mTOR-HIF1alpha signaling in HER2-defined breast cancers. PMID:27186427
Resistance to docetaxel in prostate cancer is associated with androgen receptor activation and loss of KDM5D expression. PMID:27185910
TransCONFIRM: Identification of a Genetic Signature of Response to Fulvestrant in Advanced Hormone Receptor-Positive Breast Cancer. PMID:27185372
The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma. PMID:27184927
Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease. PMID:27184417
Multiplexed immunofluorescence delineates proteomic cancer cell states associated with metabolism. PMID:27182557
Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo. PMID:27182052
An unregulated regulator: Vasa expression in the development of somatic cells and in tumorigenesis. PMID:27179696
Post-translational regulation of the cleaved fragment of Par-4 in ovarian and endometrial cancer cells. PMID:27175591
DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers. PMID:27174913
Prognostic value of DNA repair based stratification of hepatocellular carcinoma. PMID:27174663
Identifying and targeting determinants of melanoma cellular invasion. PMID:27172792
Coexistence of YWHAZ amplification predicts better prognosis in muscle-invasive bladder cancer with CDKN2A or TP53 loss. PMID:27167196
Integrated Genomics for Pinpointing Survival Loci within Arm-Level Somatic Copy Number Alterations. PMID:27165745
Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients. PMID:27165743
Squamous Cell Cancers: A Unified Perspective on Biology and Genetics. PMID:27165741
NLRC5/MHC class I transactivator is a target for immune evasion in cancer. PMID:27162338
FOXM1 and FOXQ1 Are Promising Prognostic Biomarkers and Novel Targets of Tumor-Suppressive miR-342 in Human Colorectal Cancer. PMID:27162244
Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid. PMID:27161972
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes. PMID:27161491
Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. PMID:27160553
Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers. PMID:27158381
Visual Omics Explorer (VOE): a cross-platform portal for interactive data visualization. PMID:27153572
Molecular analysis of a male breast cancer patient with prolonged stable disease under mTOR/PI3K inhibitors BEZ235/everolimus. PMID:27148582
Collecting duct carcinoma of the kidney is associated with CDKN2A deletion and SLC family gene up-regulation. PMID:27144525
Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters. PMID:27144334
Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma. PMID:27144065
Hawaii natural compounds are promising to reduce ovarian cancer deaths. PMID:27142977
The Therapeutic Potential of Targeting the HGF/cMET Axis in Ovarian Cancer. PMID:27139908
MET inhibition overcomes radiation resistance of glioblastoma stem-like cells. PMID:27138567
Pan-Cancer Analysis of Mutation Hotspots in Protein Domains. PMID:27135912
An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation. PMID:27135738
G-DOC Plus - an integrative bioinformatics platform for precision medicine. PMID:27130330
Zinc Finger Homeodomain Factor Zfhx3 Is Essential for Mammary Lactogenic Differentiation by Maintaining Prolactin Signaling Activity. PMID:27129249
Data Requirements for Model-Based Cancer Prognosis Prediction. PMID:27127404
WRN Promoter CpG Island Hypermethylation Does Not Predict More Favorable Outcomes for Patients with Metastatic Colorectal Cancer Treated with Irinotecan-Based Therapy. PMID:27121793
Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition. PMID:27120806
MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1. PMID:27119506
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. PMID:27117709
BMP2/BMPR1A is linked to tumour progression in dedifferentiated liposarcomas. PMID:27114889
Defining actionable mutations for oncology therapeutic development. PMID:27112209
Prognostic microRNA signatures derived from The Cancer Genome Atlas for head and neck squamous cell carcinomas. PMID:27109697
Elevated integrin α6β4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer. PMID:27107458
Potential Role of TRAIL in Metastasis of Mutant KRAS Expressing Lung Adenocarcinoma. PMID:27106232
Deregulation of Rho GTPases in cancer. PMID:27104658
TET2 Negatively Regulates Nestin Expression in Human Melanoma. PMID:27102770
The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma. PMID:27102439
Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma. PMID:27102295
Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas. PMID:27096031
Thin and thick primary cutaneous melanomas reveal distinct patterns of somatic copy number alterations. PMID:27095580
Gastric Lgr5(+) stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice. PMID:27091432
The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy. PMID:27089238
Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma. PMID:27089179
Retrospective Study of Sirolimus and Cyclophosphamide in Patients with Advanced Differentiated Thyroid Cancers. PMID:27088062
Posterior Contraction Rates of the Phylogenetic Indian Buffet Processes. PMID:27087886
Mutation Yield of a 34-Gene Solid Tumor Panel in Community-Based Tumor Samples. PMID:27084556
Upregulation of RNA Processing Factors in Poorly Differentiated Lung Cancer Cells. PMID:27084424
Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma. PMID:27083054
Integrating Genomics Into Clinical Pediatric Oncology Using the Molecular Tumor Board at the Memorial Sloan Kettering Cancer Center. PMID:27082517
MERTK as a novel therapeutic target in head and neck cancer. PMID:27081701
ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion. PMID:27081041
Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells. PMID:27080533
Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence. PMID:27075627
Analysis of the inhibitors of apoptosis identifies BIRC3 as a facilitator of malignant progression in glioma. PMID:27074575
ProNGF is a potential diagnostic biomarker for thyroid cancer. PMID:27074571
The tandem duplicator phenotype as a distinct genomic configuration in cancer. PMID:27071093
Critical role of DEK and its regulation in tumorigenesis and metastasis of hepatocellular carcinoma. PMID:27057626
Immunological metagene signatures derived from immunogenic cancer cell death associate with improved survival of patients with lung, breast or ovarian malignancies: A large-scale meta-analysis. PMID:27057433
MicroRNA expression and function in prostate cancer: a review of current knowledge and opportunities for discovery. PMID:27056344
Evaluation of FGFR3 as a Therapeutic Target in Head and Neck Squamous Cell Carcinoma. PMID:27053219
Biological Features of Human Papillomavirus-related Head and Neck Cancers Contributing to Improved Response. PMID:27052795
Bioinformatic exploration of MTA1-regulated gene networks in colon cancer. PMID:27052252
Regulation of Cancer Cell Behavior by the Small GTPase Rab13. PMID:27044746
TGF-β signaling in liver and gastrointestinal cancers. PMID:27039259
HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B. PMID:27035903
The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC. PMID:27030265
The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer. PMID:27027432
Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype. PMID:27026680
The Roles of MDM2 and MDMX in Cancer. PMID:27022975
Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma. PMID:27022132
Chaperonin Containing TCP-1 Protein Level in Breast Cancer Cells Predicts Therapeutic Application of a Cytotoxic Peptide. PMID:27012814
caOmicsV: an R package for visualizing multidimensional cancer genomic data. PMID:27005934
Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer. PMID:27005559
TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene. PMID:27005522
Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer. PMID:27004849
Plasminogen activator inhibitor-1 enhances radioresistance and aggressiveness of non-small cell lung cancer cells. PMID:27004408
Genomic landscape of DNA repair genes in cancer. PMID:27004405
AR-42 induces apoptosis in human hepatocellular carcinoma cells via HDAC5 inhibition. PMID:26993777
Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation. PMID:26993606
Transforming Growth Factor-β Is an Upstream Regulator of Mammalian Target of Rapamycin Complex 2-Dependent Bladder Cancer Cell Migration and Invasion. PMID:26988652
Phenotypically Dormant and Immature Leukaemia Cells Display Increased Ribosomal Protein S6 Phosphorylation. PMID:26985829
Mutation based treatment recommendations from next generation sequencing data: a comparison of web tools. PMID:26980737
Genomic markers of panitumumab resistance including ERBB2/ HER2 in a phase II study of KRAS wild-type (wt) metastatic colorectal cancer (mCRC). PMID:26980732
Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways. PMID:26977886
Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma. PMID:26977885
Breast cancer survival among young women: a review of the role of modifiable lifestyle factors. PMID:26970739
MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma. PMID:26967478
Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1. PMID:26966246
12-HETER1/GPR31, a high-affinity 12(S)-hydroxyeicosatetraenoic acid receptor, is significantly up-regulated in prostate cancer and plays a critical role in prostate cancer progression. PMID:26965684
Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid cystic carcinoma. PMID:26958807
OpenHealth Platform for Interactive Contextualization of Population Health Open Data. PMID:26958160
The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer. PMID:26957540
Distinct Metabolic Signature of Human Bladder Cancer Cells Carrying an Impaired Fanconi Anemia Tumor-Suppressor Signaling Pathway. PMID:26956768
DNA methylation modifies the association between obesity and survival after breast cancer diagnosis. PMID:26945992
The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation. PMID:26943038
Long non-coding RNAs as prognostic markers in human breast cancer. PMID:26942882
FGFR1 promotes the stem cell-like phenotype of FGFR1-amplified non-small cell lung cancer cells through the Hedgehog pathway. PMID:26936993
ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma. PMID:26936505
Activation-Induced Cytidine Deaminase Links Ovulation-Induced Inflammation and Serous Carcinogenesis. PMID:26936395
Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression. PMID:26934321
AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours. PMID:26934201
Sharing big biomedical data. PMID:26929900
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. PMID:26928227
SOX5 is involved in balanced MITF regulation in human melanoma cells. PMID:26927636
Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition. PMID:26926107
Mutational Landscape of Aggressive Prostate Tumors in African American Men. PMID:26921337
Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival. PMID:26921331
An Integrative Pharmacogenomic Approach Identifies Two-drug Combination Therapies for Personalized Cancer Medicine. PMID:26916442
The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair. PMID:26915295
Mutations in PIK3CA sensitize breast cancer cells to physiologic levels of aspirin. PMID:26915040
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. PMID:26912360
Prevalence and phenotypic correlations of EIF1AX mutations in thyroid nodules. PMID:26911375
Elevated expression of IFN-inducible CXCR3 ligands predicts poor prognosis in patients with non-metastatic clear-cell renal cell carcinoma. PMID:26910919
Genomic analyses identify molecular subtypes of pancreatic cancer. PMID:26909576
Nucleotide excision repair (NER) alterations as evolving biomarkers and therapeutic targets in epithelial cancers. PMID:26909362
Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia. PMID:26908329
MiR-494 Inhibits Epithelial Ovarian Cancer Growth by Targeting c-Myc. PMID:26908019
Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells. PMID:26907172
Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer. PMID:26901067
Association between cytoplasmic CRABP2, altered retinoic acid signaling, and poor prognosis in glioblastoma. PMID:26893190
GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification. PMID:26887977
Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling. PMID:26884713
Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients. PMID:26884349
Discovery of candidate tumor biomarkers for treatment with intraperitoneal chemotherapy for ovarian cancer. PMID:26883286
Involvement of calprotectin (S100A8/A9) in molecular pathways associated with HNSCC. PMID:26883112
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination. PMID:26881969
Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators. PMID:26879975
BCORL1 is an independent prognostic marker and contributes to cell migration and invasion in human hepatocellular carcinoma. PMID:26879601
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers. PMID:26878173
BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1. PMID:26877780
Loss of DAB2IP in RCC cells enhances their growth and resistance to mTOR-targeted therapies. PMID:26876207
High Expression of miR-532-5p, a Tumor Suppressor, Leads to Better Prognosis in Ovarian Cancer Both In Vivo and In Vitro. PMID:26873729
Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer. PMID:26871945
The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells. PMID:26871602
Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway. PMID:26871431
Collateral Lethality: A new therapeutic strategy in oncology. PMID:26870836
Structure, expression and functions of MTA genes. PMID:26869315
Transcription factor C/EBP-β induces tumor-suppressor phosphatase PHLPP2 through repression of the miR-17-92 cluster in differentiating AML cells. PMID:26868909
Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma. PMID:26864202
Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome. PMID:26862846
TRONCO: an R package for the inference of cancer progression models from heterogeneous genomic data. PMID:26861821
Clinical and Molecular Characteristics of NF1-Mutant Lung Cancer. PMID:26861459
LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer. PMID:26860319
Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus. PMID:26859683
Differential expression of PDGFRB and EGFR in microvascular proliferation in glioblastoma. PMID:26857280
Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma. PMID:26855149
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. PMID:26855148
HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies. PMID:26853466
Web-TCGA: an online platform for integrated analysis of molecular cancer data sets. PMID:26852330
Moving towards personalised therapy in head and neck squamous cell carcinoma through analysis of next generation sequencing data. PMID:26851381
Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells. PMID:26848584
The effect of HMGB1 on the clinicopathological and prognostic features of non-small cell lung cancer. PMID:26840258
A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer. PMID:26840086
Targeting TRPM2 Channels Impairs Radiation-Induced Cell Cycle Arrest and Fosters Cell Death of T Cell Leukemia Cells in a Bcl-2-Dependent Manner. PMID:26839633
ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling. PMID:26838548
The rs11515 Polymorphism Is More Frequent and Associated With Aggressive Breast Tumors with Increased ANRIL and Decreased p16 (INK4a) Expression. PMID:26835415
MLL1 is essential for the senescence-associated secretory phenotype. PMID:26833731
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. PMID:26833729
Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma. PMID:26831905
Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma. PMID:26831717
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. PMID:26829472
Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide. PMID:26826202
A panoply of errors: polymerase proofreading domain mutations in cancer. PMID:26822575
Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer. PMID:26819452
Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss. PMID:26818109
Endothelin therapeutics in cancer: Where are we? PMID:26818060
Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers. PMID:26810754
Cascade: an RNA-seq visualization tool for cancer genomics. PMID:26810393
Integrated analysis of the prostate cancer small-nucleolar transcriptome reveals SNORA55 as a driver of prostate cancer progression. PMID:26809501
Meta-Analyses of Microarray Datasets Identifies ANO1 and FADD as Prognostic Markers of Head and Neck Cancer. PMID:26808319
Targeting therapeutic liabilities engendered by PIK3R1 mutations for cancer treatment. PMID:26807692
Amplification of the bromodomain-containing protein 4 gene in ovarian high-grade serous carcinoma is associated with worse prognosis and survival. PMID:26807235
Mechanistic Support for Combined MET and AR Blockade in Castration-Resistant Prostate Cancer. PMID:26806347
Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation. PMID:26804919
Challenges to Implementation of Global Translational Collaboration Platforms. PMID:26798845
Mutations of Chromatin Structure Regulating Genes in Human Malignancies. PMID:26796307
Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma. PMID:26790128
TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. PMID:26784546
Genomic Biomarkers for the Prediction of Stage and Prognosis of Upper Tract Urothelial Carcinoma. PMID:26778714
Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer. PMID:26777065
BRCAness revisited. PMID:26775620
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer. PMID:26771841
Mosaic 13q14 deletions in peripheral leukocytes of non-hematologic cancer cases and healthy controls. PMID:26763882
Molecular Pathways: AXL, a Membrane Receptor Mediator of Resistance to Therapy. PMID:26763248
GPR171 expression enhances proliferation and metastasis of lung cancer cells. PMID:26760963
Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A. PMID:26760764
The INO80 Complex Requires the Arp5-Ies6 Subcomplex for Chromatin Remodeling and Metabolic Regulation. PMID:26755556
SSRP1 Contributes to the Malignancy of Hepatocellular Carcinoma and Is Negatively Regulated by miR-497. PMID:26755331
Direct Calculation of Protein Fitness Landscapes through Computational Protein Design. PMID:26745411
Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence. PMID:26743006
Identification of ovarian cancer subtype-specific network modules and candidate drivers through an integrative genomics approach. PMID:26735889
Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha-Positive, PIK3CA-Mutant Breast Cancer. PMID:26733612
Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry. PMID:26732427
Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers. PMID:26725848
Overview of pre-clinical and clinical studies targeting angiogenesis in pancreatic ductal adenocarcinoma. PMID:26723874
Improved survival associated with somatic PIK3CA mutations in copy-number low endometrioid endometrial adenocarcinoma. PMID:26722235
Structure-Based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors. PMID:26721946
Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker. PMID:26719704
Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment. PMID:26719346
OASIS: web-based platform for exploring cancer multi-omics data. PMID:26716558
Improving Cancer Gene Expression Data Quality through a TCGA Data-Driven Evaluation of Identifier Filtering. PMID:26715829
Fibroblast growth factor receptor 3 protein is overexpressed in oral and oropharyngeal squamous cell carcinoma. PMID:26711175
Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer. PMID:26711141
The significance of Brf1 overexpression in human hepatocellular carcinoma. PMID:26701855
Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity. PMID:26701849
Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas. PMID:26700204
PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients. PMID:26699864
Novel kinase fusion transcripts found in endometrial cancer. PMID:26689674
The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. PMID:26687066
Regulation of breast tumorigenesis through acid sensors. PMID:26686084
Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas. PMID:26685161
EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes. PMID:26683696
IL13Rα2 signaling in colorectal cancer. PMID:26682245
Prognostic significance of FAM83D gene expression across human cancer types. PMID:26678035
Onco-proteogenomics identifies urinary S100A9 and GRN as potential combinatorial biomarkers for early diagnosis of hepatocellular carcinoma. PMID:26675302
The emerging role of Slit-Robo pathway in gastric and other gastro intestinal cancers. PMID:26674478
Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity. PMID:26672766
The Clinical Significance and Molecular Features of the Spatial Tumor Shapes in Breast Cancers. PMID:26669540
The Cellular Apoptosis Susceptibility Protein (CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis and Cell Proliferation. PMID:26668314
Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation. PMID:26668268
Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF. PMID:26660078
SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status. PMID:26654769
Understanding the role of the kynurenine pathway in human breast cancer immunobiology. PMID:26646699
The Emerging Role of ABL Kinases in Solid Tumors. PMID:26645050
HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells. PMID:26643866
Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis. PMID:26637668
DriverDBv2: a database for human cancer driver gene research. PMID:26635391
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. PMID:26621817
Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. PMID:26621741
Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma. PMID:26619122
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. PMID:26619011
Integrated genomic characterization of IDH1-mutant glioma malignant progression. PMID:26618343
Mutant p53: Multiple Mechanisms Define Biologic Activity in Cancer. PMID:26618142
Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility. PMID:26610392
Role of "oncogenic nexus" of CIP2A in breast oncogenesis: how does it work? PMID:26609493
Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer. PMID:26597303
Inhibition of pentose phosphate pathway suppresses acute myelogenous leukemia. PMID:26596840
CancerResource--updated database of cancer-relevant proteins, mutations and interacting drugs. PMID:26590406
ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. PMID:26590320
MutationAligner: a resource of recurrent mutation hotspots in protein domains in cancer. PMID:26590264
Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations. PMID:26589432
An integrated genomic analysis of Tudor domain-containing proteins identifies PHD finger protein 20-like 1 (PHF20L1) as a candidate oncogene in breast cancer. PMID:26588862
Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer. PMID:26587011
Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma. PMID:26576100
Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas. PMID:26575021
Induction of proto-oncogene BRF2 in breast cancer cells by the dietary soybean isoflavone daidzein. PMID:26573593
Datafish Multiphase Data Mining Technique to Match Multiple Mutually Inclusive Independent Variables in Large PACS Databases. PMID:26572132
Drosophila Rabex-5 restricts Notch activity in hematopoietic cells and maintains hematopoietic homeostasis. PMID:26567216
PIK3CA(H1047R) Accelerates and Enhances KRAS(G12D)-Driven Lung Tumorigenesis. PMID:26567140
Persistent androgen receptor addiction in castration-resistant prostate cancer. PMID:26566796
LINC00472 expression is regulated by promoter methylation and associated with disease-free survival in patients with grade 2 breast cancer. PMID:26564482
Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-κB regulatory genes. PMID:26564005
TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation. PMID:26563938
InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma. PMID:26561558
The potential role of PHF6 as an oncogene: a genotranscriptomic/proteomic meta-analysis. PMID:26561469
Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells. PMID:26556867
Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma. PMID:26554828
Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma. PMID:26554648
Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer. PMID:26553438
Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer. PMID:26551685
CSIOVDB: a microarray gene expression database of epithelial ovarian cancer subtype. PMID:26549805
Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion. PMID:26549256
Co-active receptor tyrosine kinases mitigate the effect of FGFR inhibitors in FGFR1-amplified lung cancers with low FGFR1 protein expression. PMID:26549034
Depletion of three combined THOC5 mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death. PMID:26549021
Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers. PMID:26546618
MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer. PMID:26545583
Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma. PMID:26538233
N-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression. PMID:26537799
Precision medicine for cancer with next-generation functional diagnostics. PMID:26536825
Integrated Analysis of Thyroid Cancer Public Datasets Reveals Role of Post-Transcriptional Regulation on Tumor Progression by Targeting of Immune System Mediators. PMID:26536459
Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation. PMID:26531827
MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. PMID:26530832
IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival. PMID:26527316
Metastatic renal cell carcinoma without evidence of a renal primary. PMID:26527083
Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet. PMID:26526858
ATP5A1 and ATP5B are highly expressed in glioblastoma tumor cells and endothelial cells of microvascular proliferation. PMID:26526033
Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers. PMID:26523969
The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma. PMID:26522722
Evaluation of tumor-derived MRI-texture features for discrimination of molecular subtypes and prediction of 12-month survival status in glioblastoma. PMID:26520762
The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo. PMID:26517239
RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors. PMID:26515496
Lentiviral vector-mediated insertional mutagenesis screen identifies genes that influence androgen independent prostate cancer progression and predict clinical outcome. PMID:26512949
Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation. PMID:26510686
A human leucyl-tRNA synthetase as an anticancer target. PMID:26508878
The Cancer Genome Atlas Clinical Explorer: a web and mobile interface for identifying clinical-genomic driver associations. PMID:26507825
A novel gammaretroviral shuttle vector insertional mutagenesis screen identifies SHARPIN as a breast cancer metastasis gene and prognostic biomarker. PMID:26506596
Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes. PMID:26506417
The Tip of the Iceberg: Clinical Implications of Genomic Sequencing Projects in Head and Neck Cancer. PMID:26506389
MEF2 transcription factors: developmental regulators and emerging cancer genes. PMID:26506234
A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma. PMID:26504497
Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. PMID:26503472
Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data. PMID:26499835
TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines. PMID:26496938
Genomic characterisation of two cancers of unknown primary cases supports a kidney cancer origin. PMID:26494726
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. PMID:26493647
GREM1 and POLE variants in hereditary colorectal cancer syndromes. PMID:26493165
Big Data: the challenge for small research groups in the era of cancer genomics. PMID:26492224
Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC). PMID:26484545
Oncogenomic portals for the visualization and analysis of genome-wide cancer data. PMID:26484415
Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination. PMID:26475525
A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients. PMID:26474971
Increased metastasis with loss of E2F2 in Myc-driven tumors. PMID:26474282
Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma. PMID:26473374
Targeting Signaling Transduction Pathways in Bladder Cancer. PMID:26472299
Deguelins, Natural Product Modulators of NF1-Defective Astrocytoma Cell Growth Identified by High-Throughput Screening of Partially Purified Natural Product Extracts. PMID:26467198
Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination. PMID:26464464
The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A. PMID:26463672
Public data and open source tools for multi-assay genomic investigation of disease. PMID:26463000
Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment. PMID:26461489
MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators. PMID:26461474
RelA-Induced Interferon Response Negatively Regulates Proliferation. PMID:26460486
Somatic human ZBTB7A zinc finger mutations promote cancer progression. PMID:26455326
JRK is a positive regulator of β-catenin transcriptional activity commonly overexpressed in colon, breast and ovarian cancer. PMID:26455321
Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer. PMID:26452386
UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO. PMID:26449661
Comprehensive serial molecular profiling of an "N of 1" exceptional non-responder with metastatic prostate cancer progressing to small cell carcinoma on treatment. PMID:26444865
Genetic Alterations in Gliosarcoma and Giant Cell Glioblastoma. PMID:26443480
Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer. PMID:26442266
Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways. PMID:26442106
Functional Role of G9a Histone Methyltransferase in Cancer. PMID:26441991
Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway. PMID:26440310
p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase. PMID:26438819
From drug response profiling to target addiction scoring in cancer cell models. PMID:26438695
Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma. PMID:26438152
Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition. PMID:26437225
Genomic landscapes of breast fibroepithelial tumors. PMID:26437033
TumorTracer: a method to identify the tissue of origin from the somatic mutations of a tumor specimen. PMID:26429708
Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer. PMID:26427375
Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma. PMID:26424075
Semantic biomedical resource discovery: a Natural Language Processing framework. PMID:26423616
Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. PMID:26420897
Molecular Pathways: Targeting Diacylglycerol Kinase Alpha in Cancer. PMID:26420856
A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells. PMID:26420058
CD151 promotes α3β1 integrin-dependent organization of carcinoma cell junctions and restrains collective cell invasion. PMID:26418968
The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression. PMID:26417066
Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications. PMID:26416562
Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism. PMID:26414444
HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families. PMID:26405587
Genomic alterations in BCL2L1 and DLC1 contribute to drug sensitivity in gastric cancer. PMID:26401016
KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27kip1. PMID:26397136
Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer. PMID:26390252
Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer. PMID:26388988
A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis. PMID:26384344
Decreased efficacy of drugs targeting the vascular endothelial growth factor pathway by the epigenetic silencing of FLT1 in renal cancer cells. PMID:26380584
Preclinical Childhood Sarcoma Models: Drug Efficacy Biomarker Identification and Validation. PMID:26380223
CDK4/6 inhibitor suppresses gastric cancer with CDKN2A mutation. PMID:26380006
Limited evidence that cancer susceptibility regions are preferential targets for somatic mutation. PMID:26374197
Splicing Factor Prp8 Interacts With NES(AR) and Regulates Androgen Receptor in Prostate Cancer Cells. PMID:26371515
RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors. PMID:26370156
Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma. PMID:26369831
Genetic variants of the autophagy pathway as prognostic indicators for prostate cancer. PMID:26365175
YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells. PMID:26364602
hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes. PMID:26364595
Gene mutations in gastric cancer: a review of recent next-generation sequencing studies. PMID:26364057
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type. PMID:26356327
WDR5 Expression Is Prognostic of Breast Cancer Outcome. PMID:26355959
Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants. PMID:26354769
Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. PMID:26354767
Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. PMID:26353928
DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines. PMID:26353782
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B. PMID:26344709
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. PMID:26344095
Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14. PMID:26341486
Identification of an oncogenic RAB protein. PMID:26338797
NF-κB: Regulation by Methylation. PMID:26337909
Targeted genomic profiling reveals recurrent KRAS mutations and gain of chromosome 1q in mesonephric carcinomas of the female genital tract. PMID:26336887
The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma. PMID:26336132
URI1 amplification in uterine carcinosarcoma associates with chemo-resistance and poor prognosis. PMID:26328264
Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation. PMID:26322231
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. PMID:26321681
Precision medicine at Memorial Sloan Kettering Cancer Center: clinical next-generation sequencing enabling next-generation targeted therapy trials. PMID:26320725
The PTTG1-targeting miRNAs miR-329, miR-300, miR-381, and miR-655 inhibit pituitary tumor cell tumorigenesis and are involved in a p53/PTTG1 regulation feedback loop. PMID:26320179
KRAS mutations in microsatellite instable gastric tumours: impact of targeted treatment and intratumoural heterogeneity. PMID:26318594
Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells. PMID:26318585
Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation. PMID:26314710
Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux. PMID:26312386
Visualizing genome and systems biology: technologies, tools, implementation techniques and trends, past, present and future. PMID:26309733
MEXPRESS: visualizing expression, DNA methylation and clinical TCGA data. PMID:26306699
Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. PMID:26305679
Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes. PMID:26304929
Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1. PMID:26302180
Somatic Mutation Spectrum of Non-Small-Cell Lung Cancer in African Americans: A Pooled Analysis. PMID:26301800
The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics. PMID:26300004
Identification of a PEAK1/ZEB1 signaling axis during TGFβ/fibronectin-induced EMT in breast cancer. PMID:26297948
Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer. PMID:26297050
Predicting Response to Histone Deacetylase Inhibitors Using High-Throughput Genomics. PMID:26296641
YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers. PMID:26295846
Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression. PMID:26294211
The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway. PMID:26293885
Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase. PMID:26292256
Pyrosequencing-Based Assays for Rapid Detection of HER2 and HER3 Mutations in Clinical Samples Uncover an E332E Mutation Affecting HER3 in Retroperitoneal Leiomyosarcoma. PMID:26287187
OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation. PMID:26283179
Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. PMID:26280536
Ras association domain family member 10 suppresses gastric cancer growth by cooperating with GSTP1 to regulate JNK/c-Jun/AP-1 pathway. PMID:26279301
Genomic Characterization of Upper Tract Urothelial Carcinoma. PMID:26278805
A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway. PMID:26276688
Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis. PMID:26274893
Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin. PMID:26272915
TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling. PMID:26268696
Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer. PMID:26267899
Activating Mutations in PIK3CA Lead to Widespread Modulation of the Tyrosine Phosphoproteome. PMID:26267517
Phospho-T356RB1 predicts survival in HPV-negative squamous cell carcinoma of the head and neck. PMID:26265441
Point mutations of the mTOR-RHEB pathway in renal cell carcinoma. PMID:26255626
The molecular landscape of premenopausal breast cancer. PMID:26251034
MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation. PMID:26245647
Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2. PMID:26244988
HER2 activating mutations are targets for colorectal cancer treatment. PMID:26243863
Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression. PMID:26243836
E-cadherin can limit the transforming properties of activating β-catenin mutations. PMID:26240067
Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth. PMID:26235139
RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression. PMID:26234677
Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis. PMID:26233892
The PI3K/AKT Pathway and Renal Cell Carcinoma. PMID:26233890
Expression array analysis of the hepatocyte growth factor invasive program. PMID:26231668
Loss of heterozygosity: what is it good for? PMID:26231170
Role of microRNAs Located on Chromosome Arm 10q in Malignant Gliomas. PMID:26223576
Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium. PMID:26222500
Predictive Factors for BRCA1 and BRCA2 Genetic Testing in an Asian Clinic-Based Population. PMID:26221963
Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomas. PMID:26221190
Next-generation sequencing to guide cancer therapy. PMID:26221189
Downregulation of dystroglycan glycosyltransferases LARGE2 and ISPD associate with increased mortality in clear cell renal cell carcinoma. PMID:26220087
The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer. PMID:26215677
Survival of patients with structurally-grouped TP53 mutations in ovarian and breast cancers. PMID:26215675
MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. PMID:26215093
The MI bundle: enabling network and structural biology in genome visualization tools. PMID:26209801
Alternative preprocessing of RNA-Sequencing data in The Cancer Genome Atlas leads to improved analysis results. PMID:26209429
LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer. PMID:26208723
Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer. PMID:26207617
Implementation of a Molecular Tumor Board: The Impact on Treatment Decisions for 35 Patients Evaluated at Dartmouth-Hitchcock Medical Center. PMID:26205736
Heregulin and HER3 are prognostic biomarkers in oropharyngeal squamous cell carcinoma. PMID:26195293
Clinicopathologic implications of NF1 gene alterations in diffuse gliomas. PMID:26190195
Reverse phase protein arrays in signaling pathways: a data integration perspective. PMID:26185419
CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma. PMID:26183406
RAC1 P29S regulates PD-L1 expression in melanoma. PMID:26176707
Poly (A) Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor. PMID:26176602
Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma. PMID:26172295
Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma. PMID:26168291
Astrocytes promote glioma invasion via the gap junction protein connexin43. PMID:26165844
Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma. PMID:26164206
TGFβ-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis. PMID:26157579
High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer. PMID:26156018
Progesterone receptor modulates ERα action in breast cancer. PMID:26153859
Decreased LRIG1 in fulvestrant-treated luminal breast cancer cells permits ErbB3 upregulation and increased growth. PMID:26148232
Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer. PMID:26140362
Integrative network analysis for survival-associated gene-gene interactions across multiple genomic profiles in ovarian cancer. PMID:26138921
Plakophilin 1-deficient cells upregulate SPOCK1: implications for prostate cancer progression. PMID:26138584
Genomic analysis and selective small molecule inhibition identifies BCL-X(L) as a critical survival factor in a subset of colorectal cancer. PMID:26134786
Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly. PMID:26134678
Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer. PMID:26121593
Heat-shock factor 2 is a suppressor of prostate cancer invasion. PMID:26119944
YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage. PMID:26119935
Computational methods and resources for the interpretation of genomic variants in cancer. PMID:26111056
Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer. PMID:26110843
Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes. PMID:26109351
The expression of microRNA-34a is inversely correlated with c-MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients. PMID:26104764
Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer. PMID:26101715
The Therapeutic Challenge of Targeting HER2 in Endometrial Cancer. PMID:26099744
DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45 (CT45) genes is associated with disease progression and reduced survival in epithelial ovarian cancer. PMID:26098711
A Single Kinase Generates the Majority of the Secreted Phosphoproteome. PMID:26091039
PAX8 expression in ovarian surface epithelial cells. PMID:26079312
Novel EPHB4 Receptor Tyrosine Kinase Mutations and Kinomic Pathway Analysis in Lung Cancer. PMID:26073592
Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer. PMID:26071483
Regulation and function of the human HSP90AA1 gene. PMID:26071189
Structural Determinants of the Mechanical Stability of α-Catenin. PMID:26070562
Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas. PMID:26070366
Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids. PMID:26068970
Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation. PMID:26065894
A critical role for HER3 in HER2-amplified and non-amplified breast cancers: function of a kinase-dead RTK. PMID:26064441
Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. PMID:26062848
Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women. PMID:26053184
Predicting censored survival data based on the interactions between meta-dimensional omics data in breast cancer. PMID:26048077
Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. PMID:26047463
Decreased SMAD4 expression is associated with induction of epithelial-to-mesenchymal transition and cetuximab resistance in head and neck squamous cell carcinoma. PMID:26046389
Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAF(V600E) Melanoma. PMID:26032958
Consistent copy number changes and recurrent PRKAR1A mutations distinguish Melanotic Schwannomas from Melanomas: SNP-array and next generation sequencing analysis. PMID:26031761
Canine spontaneous head and neck squamous cell carcinomas represent their human counterparts at the molecular level. PMID:26030765
Prostate-specific G-protein-coupled receptor collaborates with loss of PTEN to promote prostate cancer progression. PMID:26028029
Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. PMID:26028026
High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy. PMID:26026368
An Unusual Combination: KRAS and BRAF Co-mutated Metastatic Colorectal Cancer. PMID:26018827
Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs. PMID:26018524
Combined Inhibition of MEK and Plk1 Has Synergistic Antitumor Activity in NRAS Mutant Melanoma. PMID:26016894
Mutated Fanconi anemia pathway in non-Fanconi anemia cancers. PMID:26015400
RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. PMID:26005835
TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis. PMID:26001956
Integrative clinical genomics of advanced prostate cancer. PMID:26000489
Identification of differentially methylated markers among cytogenetic risk groups of acute myeloid leukemia. PMID:25996682
FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus Replication in Hepatoma Cells by Regulating Tumor Suppressor p53. PMID:25995247
Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression. PMID:25993413
Expression of polarity genes in human cancer. PMID:25991909
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. PMID:25990418
Genomic Analysis of the BMP Family in Glioblastomas. PMID:25987829
Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis. PMID:25987130
IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG. PMID:25982283
Sequencing of 279 cancer genes in ampullary carcinoma reveals trends relating to histologic subtypes and frequent amplification and overexpression of ERBB2 (HER2). PMID:25975284
Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics. PMID:25970776
Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib. PMID:25969993
A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments. PMID:25965342
TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas. PMID:25958320
Interactive analysis of large cancer copy number studies with Copy Number Explorer. PMID:25957352
Efficient exploration of pan-cancer networks by generalized covariance selection and interactive web content. PMID:25953855
A method for generating new datasets based on copy number for cancer analysis. PMID:25949998
An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy. PMID:25949894
Activation of insulin-like growth factor 1 receptor in patients with non-small cell lung cancer. PMID:25944691
Pregnancy associated plasma protein-A links pregnancy and melanoma progression by promoting cellular migration and invasion. PMID:25940796
HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses. PMID:25938541
IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma. PMID:25934889
Genetic and molecular analyses reveal G6PC as a key element connecting glucose metabolism and cell cycle control in ovarian cancer. PMID:25926381
Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma. PMID:25925892
Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN. PMID:25925379
Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining. PMID:25916843
ERBB4 is over-expressed in human colon cancer and enhances cellular transformation. PMID:25916654
Origin of cells and network information. PMID:25914760
Molecular stratification of metastatic melanoma using gene expression profiling: Prediction of survival outcome and benefit from molecular targeted therapy. PMID:25909218
Frequency and distribution of Notch mutations in tumor cell lines. PMID:25907971
Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate. PMID:25907765
Loss of Wave1 gene defines a subtype of lethal prostate cancer. PMID:25906751
Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer. PMID:25903835
HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer. PMID:25897424
KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulation. PMID:25896712
Phase II evaluation of dalantercept, a soluble recombinant activin receptor-like kinase 1 (ALK1) receptor fusion protein, for the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study 0229N. PMID:25888978
Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations. PMID:25887147
Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value. PMID:25886164
A classification system for clinical relevance of somatic variants identified in molecular profiling of cancer. PMID:25880439
Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer. PMID:25879784
AGR3 in breast cancer: prognostic impact and suitable serum-based biomarker for early cancer detection. PMID:25875093
AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas. PMID:25873175
Genomic alterations in DNA repair and chromatin remodeling genes in estrogen receptor-positive metastatic breast cancer patients with exceptional responses to capecitabine. PMID:25871911
Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion. PMID:25871389
PTEN functions by recruitment to cytoplasmic vesicles. PMID:25866245
Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer. PMID:25865225
A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine. PMID:25860647
PI3Kβ inhibitor TGX221 selectively inhibits renal cell carcinoma cells with both VHL and SETD2 mutations and links multiple pathways. PMID:25853938
The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling. PMID:25851810
Transforming growth factor-β pathway activity in glioblastoma. PMID:25849941
Studying clonal dynamics in response to cancer therapy using high-complexity barcoding. PMID:25849130
Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics. PMID:25849106
Promoter hypermethylation profiling of distant breast cancer metastases. PMID:25841351
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion. PMID:25829446
MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2. PMID:25829425
Modulation of Macrophage Gene Expression via Liver X Receptor α Serine 198 Phosphorylation. PMID:25825525
LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. PMID:25825497
The expression of DBC1/CCAR2 is associated with poor prognosis of ovarian carcinoma. PMID:25823848
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. PMID:25822087
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. PMID:25818297
Mutant p53 expression in fallopian tube epithelium drives cell migration. PMID:25810107
Loss of PLZF expression in prostate cancer by immunohistochemistry correlates with tumor aggressiveness and metastasis. PMID:25807461
Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung. PMID:25806221
Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology. PMID:25801821
Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer. PMID:25789974
Coordinate loss of MAP3K7 and CHD1 promotes aggressive prostate cancer. PMID:25770290
The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module. PMID:25769723
Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins. PMID:25762552
Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. PMID:25754088
p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration. PMID:25753393
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. PMID:25748654
Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients. PMID:25742471
ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels. PMID:25742469
Cyclin E2 is the predominant E-cyclin associated with NPAT in breast cancer cells. PMID:25741376
Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis. PMID:25740784
Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4. PMID:25737278
Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome. PMID:25732040
AKT1 E17K in Colorectal Carcinoma Is Associated with BRAF V600E but Not MSI-H Status: A Clinicopathologic Comparison to PIK3CA Helical and Kinase Domain Mutants. PMID:25714871
DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior. PMID:25713415
Genetic variants in the Hippo pathway predict biochemical recurrence after radical prostatectomy for localized prostate cancer. PMID:25707771
Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells. PMID:25703587
The lncRNA DRAIC/PCAT29 Locus Constitutes a Tumor-Suppressive Nexus. PMID:25700553
Methodological aspects of the molecular and histological study of prostate cancer: focus on PTEN. PMID:25697760
DNMT3A in haematological malignancies. PMID:25693834
Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression. PMID:25693195
Computational characterisation of cancer molecular profiles derived using next generation sequencing. PMID:25691827
The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge. PMID:25691825
Are acinic cell carcinomas of the breast and salivary glands distinct diseases? PMID:25688711
A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells. PMID:25681440
Lung Master Protocol (Lung-MAP)-A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400. PMID:25680375
La FAM fatale: USP9X in development and disease. PMID:25672900
Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism. PMID:25671108
p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. PMID:25659586
Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PMID:25658639
In silico functional pathway annotation of 86 established prostate cancer risk variants. PMID:25658610
The functional and pathologic relevance of autophagy proteases. PMID:25654548
miR-503 represses human cell proliferation and directly targets the oncogene DDHD2 by non-canonical target pairing. PMID:25653011
Unraveling the molecular genetics of head and neck cancer through genome-wide approaches. PMID:25642447
A recurrent mutation in PARK2 is associated with familial lung cancer. PMID:25640678
Beclin 1 regulates growth factor receptor signaling in breast cancer. PMID:25639875
A unique subset of epithelial ovarian cancers with platinum sensitivity and PARP inhibitor resistance. PMID:25634215
β-Adrenergic Receptor Signaling in Prostate Cancer. PMID:25629002
MYC-xing it up with PIK3CA mutation and resistance to PI3K inhibitors: summit of two giants in breast cancers. PMID:25628917
MEN1 mutations in Hürthle cell (oncocytic) thyroid carcinoma. PMID:25625803
Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling. PMID:25625625
Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy? PMID:25621172
Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. PMID:25619690
Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups. PMID:25613750
NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. PMID:25611383
Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier. PMID:25608477
Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer. PMID:25605014
Peax: interactive visual analysis and exploration of complex clinical phenotype and gene expression association. PMID:25592601
Rapid in vivo validation of candidate drivers derived from the PTEN-mutant prostate metastasis genome. PMID:25592467
RNA-guided isomerization of uridine to pseudouridine--pseudouridylation. PMID:25590339
MYC regulates the non-coding transcriptome. PMID:25587025
Identification of six new susceptibility loci for invasive epithelial ovarian cancer. PMID:25581431
BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells. PMID:25574598
Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS. PMID:25557169
Therapeutic targeting of tumor suppressor genes. PMID:25557041
The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges. PMID:25556614
Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein. PMID:25549724
Argininosuccinate synthetase (ASS) deficiency in high-grade pulmonary neuroendocrine carcinoma: an opportunity for personalized targeted therapy. PMID:25548129
A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy. PMID:25544748
Genetic alterations of histone lysine methyltransferases and their significance in breast cancer. PMID:25537518
Characterization of HGF/Met Signaling in Cell Lines Derived From Urothelial Carcinoma of the Bladder. PMID:25534569
STRIPAK components determine mode of cancer cell migration and metastasis. PMID:25531779
Loss of MLH1 confers resistance to PI3Kβ inhibitors in renal clear cell carcinoma with SETD2 mutation. PMID:25528216
Empowering biologists with multi-omics data: colorectal cancer as a paradigm. PMID:25527095
Evidence for the Influence of the Iron Regulatory MHC Class I Molecule HFE on Tumor Progression in Experimental Models and Clinical Populations. PMID:25520556
Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer. PMID:25519703
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. PMID:25514926
Loss of the Notch effector RBPJ promotes tumorigenesis. PMID:25512468
DNA methylation transcriptionally regulates the putative tumor cell growth suppressor ZNF677 in non-small cell lung cancers. PMID:25504438
Kinome-wide screening of HER2+ breast cancer cells for molecules that mediate cell proliferation or sensitize cells to trastuzumab therapy. PMID:25500906
RSUME inhibits VHL and regulates its tumor suppressor function. PMID:25500545
The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer. PMID:25491778
Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations. PMID:25490935
Oncogenic alterations in ERBB2/HER2 represent potential therapeutic targets across tumors from diverse anatomic sites of origin. PMID:25480824
Regulation of DNA damage responses and cell cycle progression by hMOB2. PMID:25460043
A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. PMID:25458841
Transcription restores DNA repair to heterochromatin, determining regional mutation rates in cancer genomes. PMID:25456125
LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression. PMID:25435372
HotSpotter: efficient visualization of driver mutations. PMID:25435088
Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1. PMID:25427824
Cooperation of DLC1 and CDK6 affects breast cancer clinical outcome. PMID:25425654
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. PMID:25420773
Key regulators in prostate cancer identified by co-expression module analysis. PMID:25418933
Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer. PMID:25416589
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. PMID:25415230
A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes. PMID:25411967
Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer. PMID:25410484
IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. PMID:25409149
LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer. PMID:25401474
Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells. PMID:25398437
Evaluation of an integrated clinical workflow for targeted next-generation sequencing of low-quality tumor DNA using a 51-gene enrichment panel. PMID:25395014
Cancer3D: understanding cancer mutations through protein structures. PMID:25392415
Oncogenic activity of the regulatory subunit p85β of phosphatidylinositol 3-kinase (PI3K). PMID:25385636
Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types. PMID:25383969
ProKinO: a unified resource for mining the cancer kinome. PMID:25382819
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. PMID:25378557
Classification models for clear cell renal carcinoma stage progression, based on tumor RNAseq expression trained supervised machine learning algorithms. PMID:25374611
The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer. PMID:25368431
SOX4 inhibits GBM cell growth and induces G0/G1 cell cycle arrest through Akt-p53 axis. PMID:25366337
Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease. PMID:25363811
Metformin and erlotinib synergize to inhibit basal breast cancer. PMID:25361177
CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling. PMID:25356755
Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. PMID:25356737
MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking. PMID:25351745
Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study. PMID:25349970
Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation. PMID:25344584
Successive distinct high-grade gliomas in L-2-hydroxyglutaric aciduria. PMID:25338511
CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression. PMID:25333262
AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues. PMID:25332711
Stromal Expression of Fibroblast Activation Protein Alpha (FAP) Predicts Platinum Resistance and Shorter Recurrence in patients with Epithelial Ovarian Cancer. PMID:25331442
Mg2+ effect on argonaute and RNA duplex by molecular dynamics and bioinformatics implications. PMID:25330448
Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer. PMID:25315765
Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities. PMID:25314076
Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis. PMID:25306547
Signal transducer and activator of transcription 5b drives malignant progression in a PDGFB-dependent proneural glioma model by suppressing apoptosis. PMID:25302990
c-Abl modulates tumor cell sensitivity to antibody-dependent cellular cytotoxicity. PMID:25300860
Multiple Components of the VHL Tumor Suppressor Complex Are Frequently Affected by DNA Copy Number Loss in Pheochromocytoma. PMID:25298778
P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer. PMID:25284585
Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors. PMID:25284480
Genomically driven precision medicine to improve outcomes in anaplastic thyroid cancer. PMID:25276134
FunSeq2: a framework for prioritizing noncoding regulatory variants in cancer. PMID:25273974
Integrated omic analysis of oropharyngeal carcinomas reveals human papillomavirus (HPV)-dependent regulation of the activator protein 1 (AP-1) pathway. PMID:25271301
Host deficiency in caveolin-2 inhibits lung carcinoma tumor growth by impairing tumor angiogenesis. PMID:25269481
Label-free LC-MSe in tissue and serum reveals protein networks underlying differences between benign and malignant serous ovarian tumors. PMID:25265318
AnimalTFDB 2.0: a resource for expression, prediction and functional study of animal transcription factors. PMID:25262351
Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas. PMID:25257301
Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. PMID:25252692
Selective targeting of KRAS-mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-mutant cells. PMID:25245095
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. PMID:25240281
The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers. PMID:25238049
Mutation and Transcriptional Profiling of Formalin-Fixed Paraffin Embedded Specimens as Companion Methods to Immunohistochemistry for Determining Therapeutic Targets in Oropharyngeal Squamous Cell Carcinoma (OPSCC): A Pilot of Proof of Principle. PMID:25236499
Modulation of sodium iodide symporter in thyroid cancer. PMID:25234361
Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma. PMID:25233932
Polymerase ɛ (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing. PMID:25224212
Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia. PMID:25220401
Clinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways. PMID:25206307
Organoid cultures derived from patients with advanced prostate cancer. PMID:25201530
Epidermal growth factor-like module containing mucin-like hormone receptor 2 expression in gliomas. PMID:25200831
Induction of integrin α2 in a highly bone metastatic human prostate cancer cell line: roles of RANKL and AR under three-dimensional suspension culture. PMID:25200184
Endothelin-1/endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis. PMID:25194819
A new tumor suppressor role for the Notch pathway in bladder cancer. PMID:25194568
Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. PMID:25188500
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. PMID:25187556
Prominin-1 (CD133) defines both stem and non-stem cell populations in CNS development and gliomas. PMID:25184684
The LRIG family: enigmatic regulators of growth factor receptor signaling. PMID:25183430
RTCGAToolbox: a new tool for exporting TCGA Firehose data. PMID:25181531
ATR inhibition preferentially targets homologous recombination-deficient tumor cells. PMID:25174396
Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions. PMID:25164765
Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy. PMID:25162504
ContrastRank: a new method for ranking putative cancer driver genes and classification of tumor samples. PMID:25161249
Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells. PMID:25153725
Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors. PMID:25139989
Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis. PMID:25138050
hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3. PMID:25120384
Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. PMID:25117820
Identification of 33 candidate oncogenes by screening for base-specific mutations. PMID:25117815
BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization. PMID:25115300
Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer. PMID:25114896
Candidate prognostic markers in breast cancer: focus on extracellular proteases and their inhibitors. PMID:25114586
Available resources and challenges for the clinical annotation of somatic variations. PMID:25111663
PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors. PMID:25103565
Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer. PMID:25096367
Oncogene-mediated regulation of p53 ISGylation and functions. PMID:25071020
The structural network of Interleukin-10 and its implications in inflammation and cancer. PMID:25056661
From genotype to functional phenotype: unraveling the metabolomic features of colorectal cancer. PMID:25055199
Targeting of histone deacetylases in brain tumors. PMID:25054580
Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma. PMID:25051363
Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression. PMID:25026213
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. PMID:25026211
Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): an oncoprotein with many hands. PMID:25015035
Visualizing molecular profiles of glioblastoma with GBM-BioDP. PMID:25010047
Versican regulates metastasis of epithelial ovarian carcinoma cells and spheroids. PMID:24999371
Inhibition of BMP signaling suppresses metastasis in mammary cancer. PMID:24998846
Proteogenomic convergence for understanding cancer pathways and networks. PMID:24994965
Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination. PMID:24987060
Different biochemical properties explain why two equivalent Gα subunit mutants cause unrelated diseases. PMID:24982418
Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer. PMID:24981109
Osteoprotegerin expression in triple-negative breast cancer cells promotes metastasis. PMID:24976340
Blast crisis Ph+ chronic myeloid leukemia with NUP98/HOXA13 up-regulating MSI2. PMID:24971156
Constitutive androstane receptor ligands modulate the anti-tumor efficacy of paclitaxel in non-small cell lung cancer cells. PMID:24959746
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. PMID:24957944
3'UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network. PMID:24953077
WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies. PMID:24932569
The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q). PMID:24931631
Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. PMID:24931142
Molecular pathways: PI3K pathway phosphatases as biomarkers for cancer prognosis and therapy. PMID:24928944
Inhibitor of differentiation 4 (ID4) inactivation promotes de novo steroidogenesis and castration-resistant prostate cancer. PMID:24921661
Bioinformatics for precision medicine in oncology: principles and application to the SHIVA clinical trial. PMID:24910641
MicroRNA Machinery Genes as Novel Biomarkers for Cancer. PMID:24904827
Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. PMID:24898756
C-X-C motif chemokine 12/C-X-C chemokine receptor type 7 signaling regulates breast cancer growth and metastasis by modulating the tumor microenvironment. PMID:24886617
Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling. PMID:24876273
MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival. PMID:24866769
Mechanisms promoting escape from mitotic stress-induced tumor cell death. PMID:24860162
Bioenergetic analysis of ovarian cancer cell lines: profiling of histological subtypes and identification of a mitochondria-defective cell line. PMID:24858344
Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors. PMID:24849047
Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer. PMID:24840646
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. PMID:24836576
Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth. PMID:24816188
Unique molecular signatures as a hallmark of patients with metastatic breast cancer: implications for current treatment paradigms. PMID:24811890
Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. PMID:24810057
The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA. PMID:24798327
E2F activators signal and maintain centrosome amplification in breast cancer cells. PMID:24797070
Oncogenic protein MTBP interacts with MYC to promote tumorigenesis. PMID:24786788
Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society. PMID:24777629
Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. PMID:24755468
Novel genetic targets in endometrial cancer. PMID:24750045
Interactive Visualization for Patient-to-Patient Comparison. PMID:24748858
Class I HDACs Affect DNA Replication, Repair, and Chromatin Structure: Implications for Cancer Therapy. PMID:24730655
S-score: a scoring system for the identification and prioritization of predicted cancer genes. PMID:24710071
In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift. PMID:24706837
DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies. PMID:24699305
SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker. PMID:24681808
Survivin transcript variant 2 drives angiogenesis and malignant progression in proneural gliomas. PMID:24676140
Modeling mutual exclusivity of cancer mutations. PMID:24675718
Mining genome sequencing data to identify the genomic features linked to breast cancer histopathology. PMID:24672738
Structural pathways of cytokines may illuminate their roles in regulation of cancer development and immunotherapy. PMID:24670367
A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease. PMID:24668645
A framework for organizing cancer-related variations from existing databases, publications and NGS data using a High-performance Integrated Virtual Environment (HIVE). PMID:24667251
Prediction of individualized therapeutic vulnerabilities in cancer from genomic profiles. PMID:24665131
Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer. PMID:24662921
ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency. PMID:24662920
MCM10: one tool for all-Integrity, maintenance and damage control. PMID:24662891
Recurrent SMARCA4 mutations in small cell carcinoma of the ovary. PMID:24658004
Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type. PMID:24658002
Role of osteopontin in the pathophysiology of cancer. PMID:24657887
PTEN function: the long and the short of it. PMID:24656806
Targeting TBP-Associated Factors in Ovarian Cancer. PMID:24653979
Status of PI3K/Akt/mTOR pathway inhibitors in lymphoma. PMID:24650973
Lung tumourigenesis in a conditional Cul4A transgenic mouse model. PMID:24648314
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. PMID:24631838
Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma. PMID:24628946
Masking epistasis between MYC and TGF-β pathways in antiangiogenesis-mediated colon cancer suppression. PMID:24627270
CHD7 expression predicts survival outcomes in patients with resected pancreatic cancer. PMID:24626090
Driver mutations of cancer epigenomes. PMID:24622842
Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy. PMID:24622468
Nullifying the CDKN2AB locus promotes mutant K-ras lung tumorigenesis. PMID:24618618
Translational research platforms integrating clinical and omics data: a review of publicly available solutions. PMID:24608524
Mdmx promotes genomic instability independent of p53 and Mdm2. PMID:24608433
Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells. PMID:24606123
p62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to phosphatidylinositol 3-kinase pathway inhibitors. PMID:24599075
Prostate cancer metastasis-driving genes: hurdles and potential approaches in their identification. PMID:24589457
Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance. PMID:24584939
Collection, integration and analysis of cancer genomic profiles: from data to insight. PMID:24584084
Replicative DNA polymerase mutations in cancer. PMID:24583393
Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma. PMID:24578576
DDB2 suppresses tumorigenicity by limiting the cancer stem cell population in ovarian cancer. PMID:24574518
Estrogen signaling crosstalk: Implications for endocrine resistance in ovarian cancer. PMID:24565562
ARID1B is a specific vulnerability in ARID1A-mutant cancers. PMID:24562383
Incorporating inter-relationships between different levels of genomic data into cancer clinical outcome prediction. PMID:24561168
A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer. PMID:24551133
KRAS (but not BRAF) mutations in ovarian serous borderline tumour are associated with recurrent low-grade serous carcinoma. PMID:24549645
The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. PMID:24532689
SYK allelic loss and the role of Syk-regulated genes in breast cancer survival. PMID:24523870
NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels. PMID:24521615
Relative impact of multi-layered genomic data on gene expression phenotypes in serous ovarian tumors. PMID:24521303
Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer. PMID:24519926
Chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent. PMID:24505270
The Mdm network and its regulation of p53 activities: a rheostat of cancer risk. PMID:24488925
Genomic tools in acute myeloid leukemia: From the bench to the bedside. PMID:24474533
Non-synonymous variations in cancer and their effects on the human proteome: workflow for NGS data biocuration and proteome-wide analysis of TCGA data. PMID:24467687
Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells. PMID:24465609
Deregulation of the phosphatase, PP2A is a common event in breast cancer, predicting sensitivity to FTY720. PMID:24460909
GATA2 as a potential metastasis-driving gene in prostate cancer. PMID:24448395
Beyond E-cadherin: roles of other cadherin superfamily members in cancer. PMID:24442140
Systems level-based RNAi screening by high content analysis identifies UBR5 as a regulator of estrogen receptor-α protein levels and activity. PMID:24441042
Suppression of GNAI2 message in ovarian cancer. PMID:24423449
Clustering gene expression regulators: new approach to disease subtyping. PMID:24416320
Immune heterogeneity of glioblastoma subtypes: extrapolation from the cancer genome atlas. PMID:24409449
FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis. PMID:24406338
Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. PMID:24398324
Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer. PMID:24395800
The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity. PMID:24393003
A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. PMID:24390282
Therapeutic targeting of cancers with loss of PTEN function. PMID:24387334
The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation. PMID:24386507
MAP3K1: Genomic Alterations in Cancer and Function in Promoting Cell Survival or Apoptosis. PMID:24386504
Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma. PMID:24379610
Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers. PMID:24366882
ATHENA: Identifying interactions between different levels of genomic data associated with cancer clinical outcomes using grammatical evolution neural network. PMID:24359638
Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets. PMID:24356096
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation. PMID:24351291
Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential. PMID:24349617
The non-coding transcriptome as a dynamic regulator of cancer metastasis. PMID:24346158
Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models. PMID:24332043
SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer. PMID:24332042
The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts. PMID:24321497
FGFR1-WNT-TGF-β signaling in prostate cancer mouse models recapitulates human reactive stroma. PMID:24305876
canSAR: updated cancer research and drug discovery knowledgebase. PMID:24304894
An emerging role of PARK2 in cancer. PMID:24297497
Characterizing the heterogeneity of triple-negative breast cancers using microdissected normal ductal epithelium and RNA-sequencing. PMID:24292813
Tracking progesterone receptor-mediated actions in breast cancer. PMID:24291072
Comparison of methods to identify aberrant expression patterns in individual patients: augmenting our toolkit for precision medicine. PMID:24286512
Comprehensive analysis of long non-coding RNAs in ovarian cancer reveals global patterns and targeted DNA amplification. PMID:24265805
Exploration of the gene fusion landscape of glioblastoma using transcriptome sequencing and copy number data. PMID:24261984
MetAmyl: a METa-predictor for AMYLoid proteins. PMID:24260292
Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. PMID:24243015
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity. PMID:24240700
6p22.3 amplification as a biomarker and potential therapeutic target of advanced stage bladder cancer. PMID:24231253
Γ-secretase components as predictors of breast cancer outcome. PMID:24223915
Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression. PMID:24220242
Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis. PMID:24220141
DriverDB: an exome sequencing database for cancer driver gene identification. PMID:24214964
Genome-wide consequences of deleting any single gene. PMID:24211263
USP22 regulates oncogenic signaling pathways to drive lethal cancer progression. PMID:24197134
Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7. PMID:24194518
Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines. PMID:24165091
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. PMID:24161930
miR-661 downregulates both Mdm2 and Mdm4 to activate p53. PMID:24141721
The molecular balancing act of p16(INK4a) in cancer and aging. PMID:24136988
Using functional signature ontology (FUSION) to identify mechanisms of action for natural products. PMID:24129700
Synergetic regulatory networks mediated by oncogene-driven microRNAs and transcription factors in serous ovarian cancer. PMID:24129674
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. PMID:24120138
Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes. PMID:24114677
Cooperative behavior of the nuclear receptor superfamily and its deregulation in prostate cancer. PMID:24104552
The molecular diversity of Luminal A breast tumors. PMID:24096568
Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing. PMID:24086756
FOXO3a loss is a frequent early event in high-grade pelvic serous carcinogenesis. PMID:24077281
Emerging landscape of oncogenic signatures across human cancers. PMID:24071851
In vitro three-dimensional modeling of fallopian tube secretory epithelial cells. PMID:24070420
Using biological pathway data with paxtools. PMID:24068901
Estrogen responsiveness of the TFIID subunit TAF4B in the normal mouse ovary and in ovarian tumors. PMID:24068106
Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy. PMID:24061648
Characterization and analysis of the composition and dynamics of the mammalian riboproteome. PMID:24055062
Cell-type specific features of circular RNA expression. PMID:24039610
IntOGen-mutations identifies cancer drivers across tumor types. PMID:24037244
Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs. PMID:24005565
Low-copy piggyBac transposon mutagenesis in mice identifies genes driving melanoma. PMID:24003131
Integrin α3β1 can function to promote spontaneous metastasis and lung colonization of invasive breast carcinoma. PMID:24002891
Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells. PMID:24002644
Functional DNA quantification guides accurate next-generation sequencing mutation detection in formalin-fixed, paraffin-embedded tumor biopsies. PMID:24001039
ErbB3 downregulation enhances luminal breast tumor response to antiestrogens. PMID:23999432
Aurora kinases in head and neck cancer. PMID:23993387
Hemochromatosis enhances tumor progression via upregulation of intracellular iron in head and neck cancer. PMID:23991213
Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancer. PMID:23966295
A pilot study of genetic variants in dopamine regulators with indoor tanning and melanoma. PMID:23947671
Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration. PMID:23942079
Clinical Significance of HER-2 Splice Variants in Breast Cancer Progression and Drug Resistance. PMID:23935627
Expression of Tra2 β in Cancer Cells as a Potential Contributory Factor to Neoplasia and Metastasis. PMID:23935626
Critical analysis of the potential for targeting STAT3 in human malignancy. PMID:23935373
Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer. PMID:23897969
Plakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis. PMID:23881279
Prolactin cooperates with loss of p53 to promote claudin-low mammary carcinomas. PMID:23873024
Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class. PMID:23864165
Role of ABL family kinases in cancer: from leukaemia to solid tumours. PMID:23842646
Evaluating cell lines as tumour models by comparison of genomic profiles. PMID:23839242
DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-β-driven epithelial-mesenchymal transition. PMID:23838884
Dissecting cancer heterogeneity with a probabilistic genotype-phenotype model. PMID:23821670
Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis. PMID:23814263
Poor survival with wild-type TP53 ovarian cancer? PMID:23800698
Intrinsic disorder in PTEN and its interactome confers structural plasticity and functional versatility. PMID:23783762
The UCSC Interaction Browser: multidimensional data views in pathway context. PMID:23748957
Tight junction proteins: from barrier to tumorigenesis. PMID:23743355
Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas. PMID:23737488
Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth. PMID:23733954
Genomics of squamous cell lung cancer. PMID:23728941
Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors. PMID:23718828
H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation. PMID:23707062
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women. PMID:23704896
The mutational landscape of adenoid cystic carcinoma. PMID:23685749
A role for PVRL4-driven cell-cell interactions in tumorigenesis. PMID:23682311
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. PMID:23644467
Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells. PMID:23621864
Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. PMID:23619167
A self-updating road map of The Cancer Genome Atlas. PMID:23595662
Clinical analysis and interpretation of cancer genome data. PMID:23589549
Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells. PMID:23574718
Diacylglycerol kinase α is a critical signaling node and novel therapeutic target in glioblastoma and other cancers. PMID:23558954
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. PMID:23550210
Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. PMID:23536305
KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers. PMID:23511557
Forget transcription: translation is where the action is. PMID:23508101
Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients. PMID:23505554
Using MEMo to discover mutual exclusivity modules in cancer. PMID:23504936
Aberrant BAF57 signaling facilitates prometastatic phenotypes. PMID:23493350
The NF-κB RelB protein is an oncogenic driver of mesenchymal glioma. PMID:23451236
Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers. PMID:23447401
Germline and somatic KLLN alterations in breast cancer dysregulate G2 arrest. PMID:23446638
In-depth characterization of the secretome of colorectal cancer metastatic cells identifies key proteins in cell adhesion, migration, and invasion. PMID:23443137
Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. PMID:23434594
canEvolve: a web portal for integrative oncogenomics. PMID:23418540
Linking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling. PMID:23408876
Next generation sequencing in cancer research and clinical application. PMID:23406336
Visualizing multidimensional cancer genomics data. PMID:23363777
Role of DNA secondary structures in fragile site breakage along human chromosome 10. PMID:23297364
ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. PMID:23243027
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. PMID:23223005
Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ. PMID:23166821
Digital transcriptome profiling of normal and glioblastoma-derived neural stem cells identifies genes associated with patient survival. PMID:23046790
53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma. PMID:22915756
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal PubMed citations: 6359.

6359 articles citing: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

BCHE as a Prognostic Biomarker in Endometrial Cancer and Its Correlation with Immunity. PMID:35915658
Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5. PMID:35915262
Prognostic impact of PDGFRA gain/amplification and MGMT promoter methylation status in patients with IDH wild-type glioblastoma. PMID:35911637
Molecular Landscape of ERBB2 Alterations in 14,956 Solid Tumors. PMID:35911441
Spectrum of BRAF Aberrations and Its Potential Clinical Implications: Insights From Integrative Pan-Cancer Analysis. PMID:35910024
A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML. PMID:35906694
Deoxythymidylate Kinase as a Promising Marker for Predicting Prognosis and Immune Cell Infiltration of Pan-cancer. PMID:35903153
Mutant p53 drives an immune cold tumor immune microenvironment in oral squamous cell carcinoma. PMID:35902768
Overexpression of OAS1 Is Correlated With Poor Prognosis in Pancreatic Cancer. PMID:35898870
JMJD8 Is an M2 Macrophage Biomarker, and It Associates With DNA Damage Repair to Facilitate Stemness Maintenance, Chemoresistance, and Immunosuppression in Pan-Cancer. PMID:35898493
The LIM Protein AJUBA is a Potential Oncogenic Target and Prognostic Marker in Human Cancer via Pan-Cancer Analysis. PMID:35898403
New Drug Development and Clinical Trial Design by Applying Genomic Information Management. PMID:35893795
The Identification by Exome Sequencing of Candidate Genes in BRCA-Negative Tunisian Patients at a High Risk of Hereditary Breast/Ovarian Cancer. PMID:35893033
FXYD3 Expression Predicts Poor Prognosis in Renal Cell Carcinoma with Immunosuppressive Tumor Microenvironment. PMID:35892856
Identification of Malignant Cell Populations Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer Using Single-Cell RNA Sequencing. PMID:35892844
AKT1 Transcriptomic Landscape in Breast Cancer Cells. PMID:35892586
Integrated Workflow for the Label-Free Isolation and Genomic Analysis of Single Circulating Tumor Cells in Pancreatic Cancer. PMID:35887203
A Regulatory Axis between Epithelial Splicing Regulatory Proteins and Estrogen Receptor α Modulates the Alternative Transcriptome of Luminal Breast Cancer. PMID:35887187
Efficient Identification of the MYC Regulator with the Use of the CRISPR Library and Context-Matched Database Screenings. PMID:35887071
Identification of Antitumor miR-30e-5p Controlled Genes; Diagnostic and Prognostic Biomarkers for Head and Neck Squamous Cell Carcinoma. PMID:35886008
Oleocanthal Attenuates Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence by Targeting SMYD2. PMID:35884603
The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth. PMID:35884550
Genomic Landscape, Clinical Features and Outcomes of Non-Small Cell Lung Cancer Patients Harboring BRAF Alterations of Distinct Functional Classes. PMID:35884534
Targeted Next-Generation Sequencing of Thymic Epithelial Tumours Revealed Pathogenic Variants in KIT, ERBB2, KRAS, and TP53 in 30% of Thymic Carcinomas. PMID:35884448
The Role of CDK Pathway Dysregulation and Its Therapeutic Potential in Soft Tissue Sarcoma. PMID:35884441
Focal Adhesion Kinase Provides a Collateral Vulnerability That Can Be Leveraged to Improve mTORC1 Inhibitor Efficacy. PMID:35884439
PRIM2 Promotes Cell Cycle and Tumor Progression in p53-Mutant Lung Cancer. PMID:35884433
Homo and Heterotypic Cellular Cross-Talk in Epithelial Ovarian Cancer Impart Pro-Tumorigenic Properties through Differential Activation of the Notch3 Pathway. PMID:35884426
Interleukin-11: A Potential Biomarker and Molecular Therapeutic Target in Non-Small Cell Lung Cancer. PMID:35883698
Oncogene addiction to GNAS in GNASR201 mutant tumors. PMID:35879396
The Aminoacyl-tRNA Synthetase and tRNA Expression Levels Are Deregulated in Cancer and Correlate Independently with Patient Survival. PMID:35877431
P-Rex1 Signaling Hub in Lower Grade Glioma Patients, Found by In Silico Data Mining, Correlates With Reduced Survival and Augmented Immune Tumor Microenvironment. PMID:35875157
The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma. PMID:35875075
Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer Analysis. PMID:35873470
Comprehensive Analysis of TRIM Family Genes in Hepatitis Virus B-Related Hepatoma Carcinoma. PMID:35873464
Expression patterns and therapeutic implications of CDK4 across multiple carcinomas: a molecular docking and MD simulation study. PMID:35870089
A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer. PMID:35869079
Integrated analysis of the clinical consequence and associated gene expression of ALK in ALK-positive human cancers. PMID:35865984
Data driven and biophysical insights into the regulation of trafficking vesicles by extracellular matrix stiffness. PMID:35865140
PRMT5 acts as a tumor suppressor by inhibiting Wnt/β-catenin signaling in murine gastric tumorigenesis. PMID:35864961
HIF1α: A Novel Biomarker with Potential Prognostic and Immunotherapy in Pan-cancer. PMID:35860430
Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. PMID:35858357
Identification and validation of a novel 16-gene prognostic signature for patients with breast cancer. PMID:35853971
Prospective role and immunotherapeutic targets of sideroflexin protein family in lung adenocarcinoma: evidence from bioinformatics validation. PMID:35851932
Comprehensive Pan-Cancer Analysis of TRPM8 in Tumor Metabolism and Immune Escape. PMID:35847920
DOCK4 as a Potential Biomarker Associated with Immune Infiltration in Stomach Adenocarcinoma: A Database Analysis. PMID:35846794
Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer. PMID:35846126
Bioinformatics analysis of SOXF family genes reveals potential regulatory mechanism and diagnostic value in cancers. PMID:35845531
The TTYH3/MK5 Positive Feedback Loop regulates Tumor Progression via GSK3-β/β-catenin signaling in HCC. PMID:35844789
Loss-of-function of the hippo transducer TAZ reduces mammary tumor growth through a myeloid-derived suppressor cell-dependent mechanism. PMID:35840667
Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis. PMID:35840569
MUC1 expressing tumor growth was retarded after human mucin 1 (MUC1) plasmid DNA immunization. PMID:35839304
Overexpressed SNRPB/D1/D3/E/F/G correlate with poor survival and immune infiltration in hepatocellular carcinoma. PMID:35836882
A systematic pan-cancer analysis identifies RIOK3 as an immunological and prognostic biomarker. PMID:35836879
Integrated in silico analysis of LRP2 mutations to immunotherapy efficacy in pan-cancer cohort. PMID:35834061
Comprehensive Analysis of Prognostic Value and Immune Infiltration of IGFBP Family Members in Glioblastoma. PMID:35832140
Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer. PMID:35831288
Clinical characteristics and prognostic factors of patients with non-small cell lung cancer having HER2 alterations. PMID:35829744
Computational estimation of quality and clinical relevance of cancer cell lines. PMID:35822563
mRNA vaccine development for cholangiocarcinoma: a precise pipeline. PMID:35821067
PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance. PMID:35820706
Genomic instability genes in lung and colon adenocarcinoma indicate organ specificity of transcriptomic impact on Copy Number Alterations. PMID:35817785
Gallic acid induces T-helper-1-like Treg cells and strengthens immune checkpoint blockade efficacy. PMID:35817479
Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer. PMID:35814476
S645C Point Mutation Suppresses Degradation of EGFR to Promote Progression of Glioblastoma. PMID:35814475
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma. PMID:35813482
High SLC20A1 Expression Is Associated With Poor Prognosis for Radiotherapy of Estrogen Receptor-positive Breast Cancer. PMID:35813014
The Role of P4HA1 in Multiple Cancer Types and its Potential as a Target in Renal Cell Carcinoma. PMID:35812752
The clinical relevance of unfolded protein response signaling in breast cancer. PMID:35812054
Prognostic Ability of Enhancer RNAs in Metastasis of Non-Small Cell Lung Cancer. PMID:35807355
BHLHE22 Expression Is Associated with a Proinflammatory Immune Microenvironment and Confers a Favorable Prognosis in Endometrial Cancer. PMID:35806162
Aldehyde Dehydrogenase 1B1 Is Implicated in DNA Damage Response in Human Colorectal Adenocarcinoma. PMID:35805102
CD73 Promotes Chronic Lymphocytic Leukemia. PMID:35804900
Theranostic Potentials of Gold Nanomaterials in Hematological Malignancies. PMID:35804818
Therapy-related clonal cytopenia as a precursor to therapy-related myeloid neoplasms. PMID:35803921
Potential value of PRKDC as a therapeutic target and prognostic biomarker in pan-cancer. PMID:35801800
Patients deriving long-term benefit from immune checkpoint inhibitors demonstrate conserved patterns of site-specific mutations. PMID:35798829
Clinical Diagnostic and Prognostic Potential of NDRG1 and NDRG2 in Hepatocellular Carcinoma Patients. PMID:35795037
A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic Targets. PMID:35791393
In silico comprehensive analysis of coding and non-coding SNPs in human mTOR protein. PMID:35788771
A Comprehensive Pan-Cancer Analysis of the Tumorigenic Role of Matrix Metallopeptidase 7 (MMP7) Across Human Cancers. PMID:35785154
Activation Versus Inhibition of IGF1R: A Dual Role in Breast Tumorigenesis. PMID:35784559
RecQ Helicase Somatic Alterations in Cancer. PMID:35782872
Identification of SHCBP1 as a potential biomarker involving diagnosis, prognosis, and tumor immune microenvironment across multiple cancers. PMID:35782736
Clinical, histopathological, and molecular features of IDH-wildtype indolent diffuse glioma: comparison with typical glioblastoma. PMID:35779193
Oncogenic role and potential regulatory mechanism of topoisomerase IIα in a pan-cancer analysis. PMID:35778520
Correlation of changes in subclonal architecture with progression in the MMRF CoMMpass study. PMID:35777247
ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform. PMID:35776213
Disassembly of α6β4-mediated hemidesmosomal adhesions promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin to focal adhesions. PMID:35773413
The close interaction between hypoxia-related proteins and metastasis in pancarcinomas. PMID:35773405
N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma. PMID:35773310
Downregulation of DNMT3A Attenuates the Warburg Effect, Proliferation, and Invasion via Promoting the Inhibition of miR-603 on HK2 in Ovarian Cancer. PMID:35770296
Exonuclease 1 is a Potential Diagnostic and Prognostic Biomarker in Hepatocellular Carcinoma. PMID:35769911
Epigenetic dysregulation in meningiomas. PMID:35769412
Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma. PMID:35761940
Integrated Multi-Omics Analysis Model to Identify Biomarkers Associated With Prognosis of Breast Cancer. PMID:35761863
Human papillomavirus targets the YAP1-LATS2 feedback loop to drive cervical cancer development. PMID:35761037
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. PMID:35760868
Adoptive cell therapy with tumour-infiltrating lymphocytes: the emerging importance of clonal neoantigen targets for next-generation products in non-small cell lung cancer. PMID:35757302
Prognostic Implication and Immunological Role of PSMD2 in Lung Adenocarcinoma. PMID:35754829
A Systematic Analysis Reveals the Prognostic and Immunological Role of Reptin/RUVBL2 in Human Tumors. PMID:35754815
TMED2/9/10 Serve as Biomarkers for Poor Prognosis in Head and Neck Squamous Carcinoma. PMID:35754792
A new deep learning technique reveals the exclusive functional contributions of individual cancer mutations. PMID:35753349
RAE1 is a prognostic biomarker and is correlated with clinicopathological characteristics of patients with hepatocellular carcinoma. PMID:35751040
Targeting signaling pathways in prostate cancer: mechanisms and clinical trials. PMID:35750683
Subtype-specific expression of MELK is partly due to copy number alterations in breast cancer. PMID:35749404
A Pancancer Study of PIEZO1 as a Prognosis and Immune Biomarker of Human Tumors. PMID:35747124
Targeting Cell Cycle Progression in HER2+ Breast Cancer: An Emerging Treatment Opportunity. PMID:35742993
Identifying the Potential Roles of PBX4 in Human Cancers Based on Integrative Analysis. PMID:35740947
Multiple Components of Protein Homeostasis Pathway Can Be Targeted to Produce Drug Synergies with VCP Inhibitors in Ovarian Cancer. PMID:35740614
MCC Gene Silencing Is a CpG Island Methylator Phenotype-Associated Factor That Predisposes Colon Cancer Cells to Irinotecan and Olaparib. PMID:35740525
Metabolomic Analysis Points to Bioactive Lipid Species and Acireductone Dioxygenase 1 (ADI1) as Potential Therapeutic Targets in Poor Prognosis Endometrial Cancer. PMID:35740505
Identification and clinical validation of NUSAP1 as a novel prognostic biomarker in ovarian cancer. PMID:35739489
Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia. PMID:35739278
Efficacy of Ipilimumab vs FOLFOX in Combination With Nivolumab and Trastuzumab in Patients With Previously Untreated ERBB2-Positive Esophagogastric Adenocarcinoma: The AIO INTEGA Randomized Clinical Trial. PMID:35737383
Clinical and Genomic Characterization of Bladder Carcinomas With Glandular Phenotype. PMID:35731998
WT1-specific TCRs directed against newly identified peptides install antitumor reactivity against acute myeloid leukemia and ovarian carcinoma. PMID:35728869
A comprehensive bioinformatics analysis to identify potential prognostic biomarkers among CC and CXC chemokines in breast cancer. PMID:35725915
Promising prognostic value of Transglutaminase type 2 and its correlation with tumor-infiltrating immune cells in skin cutaneous melanoma. PMID:35725560
Single Circulating-Tumor-Cell-Targeted Sequencing to Identify Somatic Variants in Liquid Biopsies in Non-Small-Cell Lung Cancer Patients. PMID:35723337
Mechanisms of SARS-CoV-2 and Male Infertility: Could Connexin and Pannexin Play a Role? PMID:35721552
CENP-A Regulation and Cancer. PMID:35721491
Functions of three ubiquitin-conjugating enzyme 2 genes in hepatocellular carcinoma diagnosis and prognosis. PMID:35721293
Attenuated ZHX3 expression is predictive of poor outcome for liver cancer: Indication for personalized therapy. PMID:35720472
SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma. PMID:35720314
Underexpression of LINC00173 in TCF3/PBX1-Positive Cases Is Associated With Poor Prognosis in Children With B-Cell Precursor Acute Lymphoblastic Leukemia. PMID:35719952
Differential Gene Expression and Weighted Correlation Network Dynamics in High-Throughput Datasets of Prostate Cancer. PMID:35719950
Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth. PMID:35715817
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma. PMID:35712470
A Ubiquitin-Proteasome Gene Signature for Predicting Prognosis in Patients With Lung Adenocarcinoma. PMID:35711913
Discoidin Domain Receptor 2 Expression as Worse Prognostic Marker in Invasive Breast Cancer. PMID:35711892
Iron commensalism of mesenchymal glioblastoma promotes ferroptosis susceptibility upon dopamine treatment. PMID:35710828
Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer. PMID:35710704
Smurf2 inhibition enhances chemotherapy and radiation sensitivity in non-small-cell lung cancer. PMID:35710591
Pathological and Prognostic Characterization of Craniopharyngioma Based on the Expression of TrkA, β-Catenin, Cell Cycle Markers, and BRAF V600E Mutation. PMID:35707464
Protein Kinase C Epsilon Overexpression Is Associated With Poor Patient Outcomes in AML and Promotes Daunorubicin Resistance Through p-Glycoprotein-Mediated Drug Efflux. PMID:35707351
Identification of hub genes associated with bladder cancer using bioinformatic analyses. PMID:35706790
An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors. PMID:35705641
Comprehensive analysis of KCTD family genes associated with hypoxic microenvironment and immune infiltration in lung adenocarcinoma. PMID:35705627
Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer. PMID:35705314
The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma. PMID:35703534
FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity. PMID:35703180
Comprehensive bioinformatics analysis of susceptibility genes for developmental dysplasia of the hip. PMID:35702583
Immunological role and prognostic potential of CLEC10A in pan-cancer. PMID:35702069
Founder BRCA1 mutations in Nepalese population. PMID:35698740
Genome-wide characterization of copy number variations in diffuse large B-cell lymphoma with implications in targeted therapy. PMID:35693879
Evaluation of NOTCH family genes' expression and prognostic value in prostate cancer. PMID:35693717
Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients. PMID:35693094
A novel ferroptosis-related gene signature for clinically predicting recurrence after hepatectomy of hepatocellular carcinoma patients. PMID:35693077
Prognostic value of p16, p53, and pcna in sarcoma and an evaluation of immune infiltration. PMID:35689249
No Time to Die: How Kidney Cancer Evades Cell Death. PMID:35682876
SCAMP3 Regulates EGFR and Promotes Proliferation and Migration of Triple-Negative Breast Cancer Cells through the Modulation of AKT, ERK, and STAT3 Signaling Pathways. PMID:35681787
Prediction of Adrenocortical Carcinoma Relapse and Prognosis with a Set of Novel Multigene Panels. PMID:35681785
LncRNA ZNF582-AS1 Expression and Methylation in Breast Cancer and Its Biological and Clinical Implications. PMID:35681777
Targeted Therapy for Adrenocortical Carcinoma: A Genomic-Based Search for Available and Emerging Options. PMID:35681700
An Integrative Human Pan-Cancer Analysis of Cyclin-Dependent Kinase 1 (CDK1). PMID:35681641
Model Cell Lines and Tissues of Different HGSOC Subtypes Differ in Local Estrogen Biosynthesis. PMID:35681563
GNOSIS: an R Shiny app supporting cancer genomics survival analysis with cBioPortal. PMID:35677713
Clinical Relevance of Estrogen Reactivity in the Breast Cancer Microenvironment. PMID:35677163
Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness. PMID:35676533
Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant. PMID:35676284
Papillary Thyroid Cancer and a TERT Promotor Mutation-positive Paraganglioma in a Patient With a Germline SDHB Mutation. PMID:35673401
Network pharmacology and experimental verification based research into the effect and mechanism of Aucklandiae Radix-Amomi Fructus against gastric cancer. PMID:35672352
Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation. PMID:35672316
ENDORSE: a prognostic model for endocrine therapy in estrogen-receptor-positive breast cancers. PMID:35671075
Human Melanoma-Associated Mast Cells Display a Distinct Transcriptional Signature Characterized by an Upregulation of the Complement Component 3 That Correlates With Poor Prognosis. PMID:35669782
Identification of the Putative Tumor Suppressor Characteristics of FAM107A via Pan-Cancer Analysis. PMID:35669436
A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma. PMID:35668194
Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Squamous Cell Carcinomas Identifies KMT2C as a Potential Tumor Suppressor. PMID:35664801
Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression. PMID:35664705
U1A is a positive regulator of the expression of heterologous and cellular genes involved in cell proliferation and migration. PMID:35664701
MCM10 is a Prognostic Biomarker and Correlated With Immune Checkpoints in Ovarian Cancer. PMID:35664337
Genetic and Epigenetic Mechanisms Deregulate the CRL2pVHL Complex in Hepatocellular Carcinoma. PMID:35664333
Hypoxia-regulated carbonic anhydrase IX (CAIX) protein is an independent prognostic indicator in triple negative breast cancer. PMID:35659359
An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for Apc mutation-driven intestinal tumorigenesis. PMID:35658010
A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of MEK1/2 Inhibitors in NRAS Mutant Melanoma. PMID:35657206
Mutational Analysis of Triple-Negative Breast Cancer Using Targeted Kinome Sequencing. PMID:35657000
Prognostic and Immunological Role of PPP1R14A as a Pan-Cancer Analysis Candidate. PMID:35656324
Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC). PMID:35655319
DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD. PMID:35655269
Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers. PMID:35654828
Immune landscape of a genetically engineered murine model of glioma compared with human glioma. PMID:35653194
Pan-Cancer Analysis of the Oncogenic and Immunological Role of RCN3: A Potential Biomarker for Prognosis and Immunotherapy. PMID:35651805
Significance of tumor heterogeneity of p-Smad2 and c-Met in HER2-positive gastric carcinoma with lymph node metastasis. PMID:35650563
Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer. PMID:35646860
Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis. PMID:35646543
Identification of a Cancer Stem Cells Signature of Head and Neck Squamous Cell Carcinoma. PMID:35646104
An Integrated Systematic Analysis and the Clinical Significance of Hepcidin in Common Malignancies of the Male Genitourinary System. PMID:35646093
Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer. PMID:35641987
UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer. PMID:35637955
Bioinformatic Analysis of Prognostic Value of SNTG2 with Immune Implications in Lung Adenocarcinoma. PMID:35637702
Analysis of multiple databases identifies crucial genes correlated with prognosis of hepatocellular carcinoma. PMID:35637248
Disclosing Potential Key Genes, Therapeutic Targets and Agents for Non-Small Cell Lung Cancer: Evidence from Integrative Bioinformatics Analysis. PMID:35632527
IL-13Rα2 Status Predicts GB-13 (IL13.E13K-PE4E) Efficacy in High-Grade Glioma. PMID:35631512
Validation of a Novel Three-Dimensional (3D Fusion) Gross Sampling Protocol for Clear Cell Renal Cell Carcinoma to Overcome Intratumoral Heterogeneity: The Meet-Uro 18 Study. PMID:35629151
Involvement of ORAI1/SOCE in Human AML Cell Lines and Primary Cells According to ABCB1 Activity, LSC Compartment and Potential Resistance to Ara-C Exposure. PMID:35628366
MICAL1 Monooxygenase in Autosomal Dominant Lateral Temporal Epilepsy: Role in Cytoskeletal Regulation and Relation to Cancer. PMID:35627100
Viral and Genomic Drivers of Squamous Cell Neoplasms Arising in the Lacrimal Drainage System. PMID:35626161
Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma. PMID:35626147
NEDD9 Restrains dsDNA Damage Response during Non-Small Cell Lung Cancer (NSCLC) Progression. PMID:35626121
Using GPCRs as Molecular Beacons to Target Ovarian Cancer with Nanomedicines. PMID:35625966
Making Invisible RNA Visible: Discriminative Sequencing Methods for RNA Molecules with Specific Terminal Formations. PMID:35625540
Impact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival. PMID:35624283
Proteomic and transcriptomic profiles of human urothelial cancer cells with histone deacetylase 5 overexpression. PMID:35624179
The bioinformatics and experimental analysis of the novel roles of virus infection-associated gene CDC20 for prognosis and immune infiltration in hepatocellular carcinoma. PMID:35622386
Histologic and Genotypic Characterization of Lung Cancer in the Inuit Population of the Eastern Canadian Arctic. PMID:35621648
Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma. PMID:35618788
Genetic changes associated with relapse in favorable histology Wilms tumor: A Children's Oncology Group AREN03B2 study. PMID:35617957
Comprehensive Analysis of Prognostic and immune infiltrates for FOXPs Transcription Factors in Human Breast Cancer. PMID:35614183
Mutational signatures are markers of drug sensitivity of cancer cells. PMID:35614096
SPINDOC is Highly Expressed in Pan-Cancer Samples and Can Promote the Proliferation, Invasion and Migration of Hepatocellular Carcinoma Cells by Activating Wnt/β-Catenin Signaling Pathway. PMID:35611367
Evidence of histone modification affecting ARID1A expression in colorectal cancer cell lines. PMID:35611248
Clinical characteristics and outcomes of phase I cancer patients with CCNE1 amplification: MD Anderson experiences. PMID:35610322
Hexokinase 2 is a transcriptional target and a positive modulator of AHR signalling. PMID:35609998
High expression of SLC20A1 is less effective for endocrine therapy and predicts late recurrence in ER-positive breast cancer. PMID:35605014
Emergence of hybrid states of stem-like cancer cells correlates with poor prognosis in oral cancer. PMID:35602941
Pan-Cancer Study of SHC-Adaptor Protein 1 (SHC1) as a Diagnostic, Prognostic and Immunological Biomarker in Human Cancer. PMID:35601500
PI3K/AKT/mTOR Pathway-Associated Genes Reveal a Putative Prognostic Signature Correlated with Immune Infiltration in Hepatocellular Carcinoma. PMID:35592706
Sperm Autoantigenic Protein 17 Predicts the Prognosis and the Immunotherapy Response of Cancers: A Pan-Cancer Analysis. PMID:35592314
Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells. PMID:35589724
TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signalling. PMID:35589707
Tumor and Constitutional Sequencing for Neurofibromatosis Type 1. PMID:35584348
MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer. PMID:35583005
Non-enzymatic function of WRN RECQL helicase regulates removal of topoisomerase-I-DNA covalent complexes and triggers NF-κB signaling in cancer. PMID:35582959
RET kinase alterations in targeted cancer therapy. PMID:35582449
Teaching an old dog new tricks: reactivated developmental signaling pathways regulate ABCB1 and chemoresistance in cancer. PMID:35582031
ERBB3 methylation and immune infiltration in tumor microenvironment of cervical cancer. PMID:35581263
Mutational landscape of normal epithelial cells in Lynch Syndrome patients. PMID:35581206
Transcriptional ITPR3 as potential targets and biomarkers for human pancreatic cancer. PMID:35580861
A Pan-Cancer Analysis of UBE2S in Tumorigenesis, Prognosis, Pathway, Immune Infiltration and Evasion, and Therapy Response from an Immune-Oncology Perspective. PMID:35578600
DPYSL2 interacts with JAK1 to mediate breast cancer cell migration. PMID:35575798
Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation. PMID:35574218
MethylMasteR: A Comparison and Customization of Methylation-Based Copy Number Variation Calling Software in Cancers Harboring Large Scale Chromosomal Deletions. PMID:35573871
Comprehensive analyses reveal the carcinogenic and immunological roles of ANLN in human cancers. PMID:35568883
A bioinformatic analysis of WFDC2 (HE4) expression in high grade serous ovarian cancer reveals tumor-specific changes in metabolic and extracellular matrix gene expression. PMID:35568777
The E3 Ubiquitin Ligase Fbxo4 Functions as a Tumor Suppressor: Its Biological Importance and Therapeutic Perspectives. PMID:35565262
Patient-Derived Bladder Cancer Organoid Models in Tumor Biology and Drug Testing: A Systematic Review. PMID:35565191
Updated Functional Roles of NAMPT in Carcinogenesis and Therapeutic Niches. PMID:35565188
Prognostic and Immunotherapeutic Roles of KRAS in Pan-Cancer. PMID:35563733
The Long Non-Coding RNA HOXA-AS2 Promotes Proliferation of Glioma Stem Cells and Modulates Their Inflammation Pathway Mainly through Post-Transcriptional Regulation. PMID:35563134
Identification of HGD and GSTZ1 as Biomarkers Involved Metabolic Reprogramming in Kidney Renal Clear Cell Carcinoma. PMID:35562974
Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma. PMID:35562868
Whole exome sequencing identifies novel germline variants of SLC15A4 gene as potentially cancer predisposing in familial colorectal cancer. PMID:35562597
Integrated computational analysis reveals HOX genes cluster as oncogenic drivers in head and neck squamous cell carcinoma. PMID:35562533
SNAT7 regulates mTORC1 via macropinocytosis. PMID:35561222
A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple Tumors. PMID:35559034
Retracted Article: Long non-coding RNA KCNQ1OT1 promotes osteosarcoma progression by increasing β-catenin activity. PMID:35558611
A Community-Driven, Openly Accessible Molecular Pathway Integrating Knowledge on Malignant Pleural Mesothelioma. PMID:35558518
Assessment of the prognostic value of SPOCK1 in clear cell renal cell carcinoma: a bioinformatics analysis. PMID:35558273
CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies. PMID:35550030
The Value of H2BC12 for Predicting Poor Survival Outcomes in Patients With WHO Grade II and III Gliomas. PMID:35547391
Mutual exclusivity of ESR1 and TP53 mutations in endocrine resistant metastatic breast cancer. PMID:35538119
Integrative Multi-Omics Analysis of Identified SKA3 as a Candidate Oncogene Correlates with Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma. PMID:35535142
PCMT1 Is a Potential Prognostic Biomarker and Is Correlated with Immune Infiltrates in Breast Cancer. PMID:35535040
RUNX1 is a promising prognostic biomarker and related to immune infiltrates of cancer-associated fibroblasts in human cancers. PMID:35534796
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. PMID:35534777
Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. PMID:35533575
UBE3A deletion enhances the efficiency of immunotherapy in non-small-cell lung cancer. PMID:35531878
The Role of CTNNB1 in Endometrial Cancer. PMID:35531470
Abnormal spindle-like microcephaly-associated protein promotes proliferation by regulating cell cycle in epithelial ovarian cancer. PMID:35531115
Oncogenic ACSM1 in prostate cancer is through metabolic and extracellular matrix-receptor interaction signaling pathways. PMID:35530294
Identification of immune-related biomarkers associated with tumorigenesis and prognosis in skin cutaneous melanoma. PMID:35530289
The interaction of p53 and DNA repair gene mutations and their impact on tumor mutation burden and immune response in human malignancies. PMID:35530277
HNRNPA2B1 Demonstrates Diagnostic and Prognostic Values Based on Pan-Cancer Analyses. PMID:35529270
SigCom LINCS: data and metadata search engine for a million gene expression signatures. PMID:35524556
Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration. PMID:35521520
The Apoptotic Resistance of BRCA1-Deficient Ovarian Cancer Cells is Mediated by cAMP. PMID:35517499
Functional deficiency of succinate dehydrogenase promotes tumorigenesis and development of clear cell renal cell carcinoma through weakening of ferroptosis. PMID:35510387
One-step nucleic acid amplification for intraoperative diagnosis of lymph node metastasis in lung cancer patients: a single-center prospective study. PMID:35508484
BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity. PMID:35507536
Deep Mining from Omics Data. PMID:35507271
VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells. PMID:35505422
MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling. PMID:35504869
Preliminary study on the role of the C5orf46 gene in renal cancer. PMID:35504177
Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer. PMID:35504112
Targeting SHP2 phosphatase in hematological malignancies. PMID:35503226
PAGER Web APP: An Interactive, Online Gene Set and Network Interpretation Tool for Functional Genomics. PMID:35495152
Anchored Multiplex PCR Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA. PMID:35494035
TIM-3 Expression Level on AML Blasts Correlates With Presence of Core Binding Factor Translocations Rather Than Clinical Outcomes. PMID:35494006
Expression, Prognostic Value, and Functional Mechanism of the KDM5 Family in Pancreatic Cancer. PMID:35493099
Increased expression of RUNX3 inhibits normal human myeloid development. PMID:35490198
Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response. PMID:35488273
Integrated analysis of ALK higher expression in human cancer and downregulation in LUAD using RNA molecular scissors. PMID:35486222
Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors. PMID:35484114
Functional network analysis of p85 and PI3K as potential gene targets and mechanism of oleanolic acid in overcoming breast cancer resistance to tamoxifen. PMID:35482141
DNA Polymerase Delta 1 Catalytic Subunit (POLD1) as a Prognostic Factor in Clear Cell Renal Cell Carcinoma Patients. PMID:35478106
PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy. PMID:35477555
High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer. PMID:35477477
N-Carbamoyl Alanine-Mediated Selective Targeting for CHEK2-Null Colorectal Cancer. PMID:35474765
ETS transcription factor ELF3 (ESE-1) is a cell cycle regulator in benign and malignant prostate. PMID:35472129
Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis. PMID:35467979
Comprehensive analysis of the expression, prognosis, and immune infiltrates for CHDs in human lung cancer. PMID:35467222
Role of the Mosaic Cisternal Maturation Machinery in Glycan Synthesis and Oncogenesis. PMID:35465326
The Dysregulation of SOX Family Correlates with DNA Methylation and Immune Microenvironment Characteristics to Predict Prognosis in Hepatocellular Carcinoma. PMID:35465267
Construction of a Two-Gene Immunogenomic-Related Prognostic Signature in Lung Squamous Cell Carcinoma. PMID:35463955
Identification of a Four-Gene Metabolic Signature to Evaluate the Prognosis of Colon Adenocarcinoma Patients. PMID:35462848
Blood-Based Next-Generation Sequencing in Adrenocortical Carcinoma. PMID:35462410
Characterization of transcriptome diversity and in vitro behavior of primary human high-risk breast cells. PMID:35459280
Inhibitory Response to CK II Inhibitor Silmitasertib and CDKs Inhibitor Dinaciclib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines. PMID:35457227
The Inhibitory Response to PI3K/AKT Pathway Inhibitors MK-2206 and Buparlisib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines. PMID:35457111
Identification of Potential Key Genes in Prostate Cancer with Gene Expression, Pivotal Pathways and Regulatory Networks Analysis Using Integrated Bioinformatics Methods. PMID:35456461
Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer. PMID:35456049
Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series. PMID:35455885
A Bioinformatics Evaluation of the Role of Dual-Specificity Tyrosine-Regulated Kinases in Colorectal Cancer. PMID:35454940
Combined Alcohol Exposure and KRAS Mutation in Human Pancreatic Ductal Epithelial Cells Induces Proliferation and Alters Subtype Signatures Determined by Multi-Omics Analysis. PMID:35454872
The Purinergic Landscape of Non-Small Cell Lung Cancer. PMID:35454832
Prostanoid Signaling in Cancers: Expression and Regulation Patterns of Enzymes and Receptors. PMID:35453789
Extracellular Vesicles Derived from SIPA1high Breast Cancer Cells Enhance Macrophage Infiltration and Cancer Metastasis through Myosin-9. PMID:35453742
Integrated In Silico Analyses Identify PUF60 and SF3A3 as New Spliceosome-Related Breast Cancer RNA-Binding Proteins. PMID:35453681
BRD4 Targets the KEAP1-Nrf2-G6PD Axis and Suppresses Redox Metabolism in Small Cell Lung Cancer. PMID:35453346
NEDD9 links anaplastic thyroid cancer stemness to chromosomal instability through integrated centrosome asymmetry and DNA sensing regulation. PMID:35449243
Global expression profiling of CD10 + /CD19 + pre-B lymphoblasts from Hispanic B-ALL patients correlates with comparative TARGET database analysis. PMID:35445848
Immunogenic Cell Death-Relevant Damage-Associated Molecular Patterns and Sensing Receptors in Triple-Negative Breast Cancer Molecular Subtypes and Implications for Immunotherapy. PMID:35444934
Analysis of Tumor Glycosylation Characteristics and Implications for Immune Checkpoint Inhibitor's Efficacy for Breast Cancer. PMID:35444644
Clinical Impact of 11q13.3 Amplification on Immune Cell Infiltration and Prognosis in Breast Cancer. PMID:35444456
TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer. PMID:35444240
Evaluation of a seven gene mutational profile as a prognostic factor in a population-based study of clear cell renal cell carcinoma. PMID:35444164
Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts. PMID:35440124
Co-expression patterns explain how a basic transcriptional role for MYC modulates Wnt and MAPK pathways in colon and lung adenocarcinomas. PMID:35438040
Cross-Platform in-silico Analyses Exploring Tumor Immune Microenvironment with Prognostic Value in Triple-Negative Breast Cancer. PMID:35437353
Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. PMID:35437317
Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer. PMID:35437308
PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer. PMID:35437307
Comprehensive Analysis on Prognosis and Immune Infiltration of Lysyl Oxidase Family Members in Pancreatic Adenocarcinoma With Experimental Verification. PMID:35433829
Small Non-Coding RNAs in the Human Placenta: Regulatory Roles and Clinical Utility. PMID:35432451
Pan‑cancer analyses reveal the regulation and clinical outcome association of PCLAF in human tumors. PMID:35425993
SNCA correlates with immune infiltration and serves as a prognostic biomarker in lung adenocarcinoma. PMID:35421944
Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology. PMID:35418942
The Potential Role of Genomic Signature in Stage II Relapsed Colorectal Cancer (CRC) Patients: A Mono-Institutional Study. PMID:35418781
The kinesin KIF20A promotes progression to castration-resistant prostate cancer through autocrine activation of the androgen receptor. PMID:35418689
Bioinformatics Analysis Identified Five Widely Expressed Genes Associated with Prognosis in Sarcoma. PMID:35414751
Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism. PMID:35411077
EGFR Mutations in Head and Neck Squamous Cell Carcinoma. PMID:35409179
Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma. PMID:35409173
Genetic Clonality as the Hallmark Driving Evolution of Non-Small Cell Lung Cancer. PMID:35406585
TIA1 Loss Exacerbates Fatty Liver Disease but Exerts a Dual Role in Hepatocarcinogenesis. PMID:35406476
PI3K/AKT Signaling Tips the Balance of Cytoskeletal Forces for Cancer Progression. PMID:35406424
CRABP1 in Non-Canonical Activities of Retinoic Acid in Health and Diseases. PMID:35406141
Regulation of growth, invasion and metabolism of breast ductal carcinoma through CCL2/CCR2 signaling interactions with MET receptor tyrosine kinases. PMID:35405500
Challenges and Gaps in Clinical Trial Genomic Data Management. PMID:35404674
PTPN14 Mutations and Cervical Cancer. PMID:35403138
Integrated bioinformatic pipeline using whole-exome and RNAseq data to identify germline variants correlated with cancer. PMID:35403010
DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination. PMID:35402838
PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? PMID:35402264
Proteomic-Based Machine Learning Analysis Reveals PYGB as a Novel Immunohistochemical Biomarker to Distinguish Inverted Urothelial Papilloma From Low-Grade Papillary Urothelial Carcinoma With Inverted Growth. PMID:35402263
Clinicopathologic and molecular characteristics of EGFR-mutant lung adenocarcinomas that transform to small cell lung cancer after TKI therapy. PMID:35399568
The downregulation of fibrinogen-like protein 1 inhibits the proliferation of lung adenocarcinoma via regulating MYC-target genes. PMID:35399566
Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors. PMID:35395865
Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation. PMID:35393542
CRIA: An Interactive Gene Selection Algorithm for Cancers Prediction Based on Copy Number Variations. PMID:35386679
Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma. PMID:35385731
SWAN pathway-network identification of common aneuploidy-based oncogenic drivers. PMID:35380699
Comprehensive Analysis of the Expression and Prognostic Significance of the CENP Family in Breast Cancer. PMID:35378917
The Role of the TP53 Pathway in Predicting Response to Neoadjuvant Therapy in Esophageal Adenocarcinoma. PMID:35377946
Inhibition of epidermal growth factor receptor suppresses parathyroid hormone-related protein expression in tumours and ameliorates cancer-associated cachexia. PMID:35373517
Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors. PMID:35373300
Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention. PMID:35373279
RNA 5-Methylcytosine Regulators Contribute to Metabolism Heterogeneity and Predict Prognosis in Ovarian Cancer. PMID:35372362
Lipid Droplet-Related PLIN2 in CD68+ Tumor-Associated Macrophage of Oral Squamous Cell Carcinoma: Implications for Cancer Prognosis and Immunotherapy. PMID:35372038
Prognostic Values and Underlying Regulatory Network of Cohesin Subunits in Esophageal Carcinoma. PMID:35371307
Expression and Regulation Network of HDAC3 in Acute Myeloid Leukemia and the Implication for Targeted Therapy Based on Multidataset Data Mining. PMID:35371279
The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells. PMID:35371049
Cleavage Stimulation Factor Subunit 2: Function Across Cancers and Potential Target for Chemotherapeutic Drugs. PMID:35370655
DNTTIP2 Expression is Associated with Macrophage Infiltration and Malignant Characteristics in Low-Grade Glioma. PMID:35370417
Circulating Tumor Cell-Free DNA Genes as Prognostic Gene Signature for Platinum Resistant Ovarian Cancer Diagnosis. PMID:35370397
Retinoblastoma Protein Paralogs and Tumor Suppression. PMID:35368709
Integrative Analysis of the Expression Levels and Prognostic Values for NEK Family Members in Breast Cancer. PMID:35368696
cSurvival: a web resource for biomarker interactions in cancer outcomes and in cell lines. PMID:35368077
PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity. PMID:35368039
Mutant p53: it's not all one and the same. PMID:35361963
The High Expression of Minichromosome Maintenance Complex Component 5 Is an Adverse Prognostic Factor in Lung Adenocarcinoma. PMID:35360518
New Insights Into PTBP3 in Human Cancers: Immune Cell Infiltration, TMB, MSI, PDCD1 and m6A Markers. PMID:35359851
Estrogen-Related Receptors Gene Expression and Copy Number Alteration Association With the Clinicopathologic Characteristics of Breast Cancer. PMID:35359609
KIF26B in the Prognosis and Immune Biomarking of Various Cancers: A Pan-Cancer Study. PMID:35359341
Ultrasensitive profiling of UV-induced mutations identifies thousands of subclinical facial tumors in tuberous sclerosis complex. PMID:35358092
PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer. PMID:35357905
Utility of secretagogin as a marker for the diagnosis of lung neuroendocrine carcinoma. PMID:35357570
SNRPD1/E/F/G Serve as Potential Prognostic Biomarkers in Lung Adenocarcinoma. PMID:35356432
Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma. PMID:35354817
KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis. PMID:35354467
Searching of Clinical Trials Made Easier in cBioPortal Using Patients' Genetic and Clinical Profiles. PMID:35354211
Genome-wide identification and analysis of prognostic features in human cancers. PMID:35354049
A m6Avalue predictive of prostate cancer stemness, tumor immune landscape and immunotherapy response. PMID:35350771
Bioinformatics Analysis Combined With Experiments Predicts PUDP as a Potential Prognostic Biomarker for Hepatocellular Carcinoma Through Its Interaction With Tumor Microenvironment. PMID:35350563
MCL-1 is a clinically targetable vulnerability in breast cancer. PMID:35349392
Comprehensive genomic profiling of EWSR1/FUS::CREB translocation-associated tumors uncovers prognostically significant recurrent genetic alterations and methylation-transcriptional correlates. PMID:35347249
Clinical significance of FBXW7 loss of function in human cancers. PMID:35346215
Aberrant SKP1 Expression: Diverse Mechanisms Impacting Genome and Chromosome Stability. PMID:35345853
A systematic pan-cancer study demonstrates the oncogenic function of heterogeneous nuclear ribonucleoprotein C. PMID:35344508
TP53/BRAF mutation as an aid in predicting response to immune-checkpoint inhibitor across multiple cancer types. PMID:35344507
Four m6A RNA Methylation Gene Signatures and Their Prognostic Values in Lung Adenocarcinoma. PMID:35343834
RAB2A promotes cervical cancer progression as revealed by comprehensive analysis of HPV integration and proteome in longitudinal cervical samples. PMID:35343109
Interleukin-17 programs liver progenitor cell transformation into cancer stem cells through miR-122 downregulation with increased risk of primary liver cancer initiation. PMID:35342340
Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression. PMID:35340765
Glycoprotein hormone α-subunit promotes cell proliferation and tumorigenesis in breast cancer. PMID:35340558
Upregulated phospholipase D2 expression and activity is related to the metastatic properties of melanoma. PMID:35340556
Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers. PMID:35338148
PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescence. PMID:35333404
HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer. PMID:35332131
Pan-cancer analysis identifies BIRC5 as a prognostic biomarker. PMID:35331169
Overexpressing PLOD Family Genes Predict Poor Prognosis in Pancreatic Cancer. PMID:35330878
High Mutation Burden in ER-Positive/HER2-Negative/Luminal Breast Cancers. PMID:35329928
Oncogenic Pathways in Neurodegenerative Diseases. PMID:35328644
LPPR5 Expression in Glioma Affects Growth, Vascular Architecture, and Sunitinib Resistance. PMID:35328529
Gene Expression Analysis of Biphasic Pleural Mesothelioma: New Potential Diagnostic and Prognostic Markers. PMID:35328227
p53 Immunohistochemistry and Mutation Types Mismatching in High-Grade Serous Ovarian Cancer. PMID:35328131
Visualization of the Effect of Assay Size on the Error Profile of Tumor Mutational Burden Measurement. PMID:35327986
Impact of miR-1/miR-133 Clustered miRNAs: PFN2 Facilitates Malignant Phenotypes in Head and Neck Squamous Cell Carcinoma. PMID:35327465
An Integrative Pan-Cancer Analysis of Kinesin Family Member C1 (KIFC1) in Human Tumors. PMID:35327439
At the Intersection of Cardiology and Oncology: TGFβ as a Clinically Translatable Therapy for TNBC Treatment and as a Major Regulator of Post-Chemotherapy Cardiomyopathy. PMID:35326728
Transcriptional Profiling of Malignant Melanoma Reveals Novel and Potentially Targetable Gene Fusions. PMID:35326655
The Fra-1/AP-1 Oncoprotein: From the "Undruggable" Transcription Factor to Therapeutic Targeting. PMID:35326630
SWI/SNF Antagonism of PRC2 Mediates Estrogen-Induced Progesterone Receptor Expression. PMID:35326450
Redox-Related Proteins in Melanoma Progression. PMID:35326089
Urothelial Bladder Carcinomas with High Tumor Mutation Burden Have a Better Prognosis and Targetable Molecular Defects beyond Immunotherapies. PMID:35323317
SWI/SNF Chromatin Remodeling Enzymes in Melanoma. PMID:35323214
Chemokine CCL17 Affects Local Immune Infiltration Characteristics and Early Prognosis Value of Lung Adenocarcinoma. PMID:35321241
Comprehensive bioinformatic analysis reveals oncogenic role of H2A.Z isoforms in cervical cancer progression. PMID:35317119
Neurotrophic receptor tyrosine kinase family members in secretory and non-secretory breast carcinomas. PMID:35316931
Reductive TCA cycle catalyzed by wild-type IDH2 promotes acute myeloid leukemia and is a metabolic vulnerability for potential targeted therapy. PMID:35313945
Diagnostic Value, Prognostic Value, and Immune Infiltration of LOX Family Members in Liver Cancer: Bioinformatic Analysis. PMID:35311155
Heat Shock Proteins and HSF1 in Cancer. PMID:35311075
Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium. PMID:35309931
Construction of a Pyroptosis-Related Signature for Prognostic Prediction and Characterization of Immune Microenvironment in Acute Myelogenous Leukemia. PMID:35308573
CTHRC1 is a prognosis-related biomarker correlated with immune infiltrates in colon adenocarcinoma. PMID:35307012
The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers. PMID:35304457
p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases. PMID:35304445
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia. PMID:35301220
Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon Adenocarcinoma. PMID:35300110
Identification of IL20RB as a Novel Prognostic and Therapeutic Biomarker in Clear Cell Renal Cell Carcinoma. PMID:35299868
Roles of Pyroptosis-Related Gene Signature in Prediction of Endometrial Cancer Outcomes. PMID:35299842
HER2 expression, copy number variation and survival outcomes in HER2-low non-metastatic breast cancer: an international multicentre cohort study and TCGA-METABRIC analysis. PMID:35296300
DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation. PMID:35296003
The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes. PMID:35294876
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. PMID:35294260
Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects. PMID:35292619
Aberrations in SMAD family of genes among HNSCC patients. PMID:35291342
An integrated bioinformatic investigation of mitochondrial solute carrier family 25 (SLC25) in colon cancer followed by preliminary validation of member 5 (SLC25A5) in tumorigenesis. PMID:35288533
vWCluster: Vector-valued optimal transport for network based clustering using multi-omics data in breast cancer. PMID:35286348
Diverse Chromobox Family Members: Potential Prognostic Biomarkers and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma. PMID:35282653
Pan-Cancer Analyses Confirmed the Ferroptosis-Related Gene SLC7A11 as a Prognostic Biomarker for Cancer. PMID:35282646
A Pan-Cancer In Silico Analysis of the COVID-19 Internalization Protease: Transmembrane Proteaseserine-2. PMID:35281819
Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment. PMID:35281414
Integrated Analysis of Energy Metabolism Signature-Identified Distinct Subtypes of Bladder Urothelial Carcinoma. PMID:35281080
Identification and Validation of a Pyroptosis-Related Prognostic Model for Gastric Cancer. PMID:35280928
ANP32 Family as Diagnostic, Prognostic, and Therapeutic Biomarker Related to Immune Infiltrates in Hepatocellular Carcinoma. PMID:35280441
SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/β-catenin signaling. PMID:35277657
A pan-cancer analysis of the oncogenic role of Holliday junction recognition protein in human tumors. PMID:35274047
Pan-Cancer Transcriptome and Immune Infiltration Analyses Reveal the Oncogenic Role of Far Upstream Element-Binding Protein 1 (FUBP1). PMID:35274005
LIMK2 Is a Novel Prognostic Biomarker and Correlates With Tumor Immune Cell Infiltration in Lung Squamous Cell Carcinoma. PMID:35273591
A saturation-mutagenesis analysis of the interplay between stability and activation in Ras. PMID:35272765
Production and Stabilization of Specific Upregulated Long Noncoding RNA HOXD-AS2 in Glioblastomas Are Mediated by TFE3 and miR-661, Respectively. PMID:35269968
Semaphorin 6C Suppresses Proliferation of Pancreatic Cancer Cells via Inhibition of the AKT/GSK3/β-Catenin/Cyclin D1 Pathway. PMID:35269749
CK1 Is a Druggable Regulator of Microtubule Dynamics and Microtubule-Associated Processes. PMID:35267653
Understanding Retinoblastoma Post-Translational Regulation for the Design of Targeted Cancer Therapies. PMID:35267571
Evaluation of the Clinical Utility of Genomic Profiling to Inform Selection of Clinical Trial Therapy in Salivary Gland Cancer. PMID:35267442
Targeting Protein Kinase C for Cancer Therapy. PMID:35267413
Long Noncoding RNA LOC554202 Predicts a Poor Prognosis and Correlates with Immune Infiltration in Thyroid Cancer. PMID:35265169
MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization. PMID:35264604
Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas. PMID:35264242
Assessment of POLE and POLD1 mutations as prognosis and immunotherapy biomarkers for stomach adenocarcinoma. PMID:35261896
H2AX mRNA expression reflects DNA repair, cell proliferation, metastasis, and worse survival in breast cancer. PMID:35261802
APOBEC3F expression in triple-negative breast cancer is associated with tumor microenvironment infiltration and activation of cancer immunity and improved survival. PMID:35261799
Intratumoral density of regulatory T cells is a predictor of host immune response and chemotherapy response in colorectal cancer. PMID:35261782
Upregulation of Cyclin B2 (CCNB2) in breast cancer contributes to the development of lymphovascular invasion. PMID:35261781
The prognostic effect of PNN in digestive tract cancers and its correlation with the tumor immune landscape in colon adenocarcinoma. PMID:35257416
Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer. PMID:35256598
UBIAD1 and CoQ10 protect melanoma cells from lipid peroxidation-mediated cell death. PMID:35255427
Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development. PMID:35252866
Targeting KRAS Mutant in Non-Small Cell Lung Cancer: Novel Insights Into Therapeutic Strategies. PMID:35251972
CNViz: An R/Shiny Application for Interactive Copy Number Variant Visualization in Cancer. PMID:35251754
Computational simulations of identified marine-derived natural bioactive compounds as potential inhibitors of oral cancer. PMID:35251696
A single-nucleotide-polymorphism in the 5'-flanking region of MSX1 gene as a predictive marker candidate for platinum-based therapy of esophageal carcinoma. PMID:35251318
Prognostic Significance and Therapeutic Target of CXC Chemokines in the Microenvironment of Lung Adenocarcinoma. PMID:35250303
High RAD51 gene expression is associated with aggressive biology and with poor survival in breast cancer. PMID:35249172
Cellular mechanisms underlying response and resistance to CDK4/6 inhibitors in the treatment of hormone receptor-positive breast cancer. PMID:35248122
DrGA: cancer driver gene analysis in a simpler manner. PMID:35247965
Signal transducer and activator of transcription family is a prognostic marker associated with immune infiltration in endometrial cancer. PMID:35244291
DYRK1A suppression attenuates HIF‑1α accumulation and enhances the anti‑liver cancer effects of regorafenib and sorafenib under hypoxic conditions. PMID:35244188
Comprehensive Analysis of Potential Correlation Between Solute Carrier 1A (SLC1A) Family and Lung Adenocarcinoma. PMID:35241927
LPAR2 correlated with different prognosis and immune cell infiltration in head and neck squamous cell carcinoma and kidney renal clear cell carcinoma. PMID:35241179
Pan-cancer analysis of ARID family members as novel biomarkers for immune checkpoint inhibitor therapy. PMID:35239432
Gα12 and Gα13: Versatility in Physiology and Pathology. PMID:35237598
Network Pharmacology Study and Experimental Validation of Yiqi Huayu Decoction Inducing Ferroptosis in Gastric Cancer. PMID:35237519
Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin. PMID:35235808
Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate. PMID:35228743
Experimental models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor. PMID:35228656
Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) expression in glioblastoma is driven by ETS1- and MYBL2-dependent transcriptional activation. PMID:35228525
Abundant expression of ferroptosis-related SAT1 is related to unfavorable outcome and immune cell infiltration in low-grade glioma. PMID:35227235
Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study. PMID:35227109
Comprehensive Analysis of the Glycolysis-Related Gene Prognostic Signature and Immune Infiltration in Endometrial Cancer. PMID:35223866
Diagnostic, Therapeutic, and Prognostic Value of the m6A Writer Complex in Hepatocellular Carcinoma. PMID:35223847
Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms. PMID:35223844
Clinical Significance of TET2 in Female Cancers. PMID:35223782
SCNN1A Overexpression Correlates with Poor Prognosis and Immune Infiltrates in Ovarian Cancer. PMID:35221714
Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc. PMID:35217790
A Novel Role of Arrhythmia-Related Gene KCNQ1 Revealed by Multi-Omic Analysis: Theragnostic Value and Potential Mechanisms in Lung Adenocarcinoma. PMID:35216393
Metabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival. PMID:35213227
Therapeutic effects of TM4SF5-targeting chimeric and humanized monoclonal antibodies in hepatocellular and colon cancer models. PMID:35211652
SLC39A1 Overexpression is Associated with Immune Infiltration in Hepatocellular Carcinoma and Promotes Its Malignant Progression. PMID:35211427
A Review of Circulating Tumor DNA in the Diagnosis and Monitoring of Esophageal Cancer. PMID:35210388
Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment. PMID:35205761
Discoidin Domain Receptor 1 Expression in Colon Cancer: Roles and Prognosis Impact. PMID:35205677
Identification of DPP4/CTNNB1/MET as a Theranostic Signature of Thyroid Cancer and Evaluation of the Therapeutic Potential of Sitagliptin. PMID:35205190
A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors. PMID:35205150
Identification of Key Proteins from the Alternative Lengthening of Telomeres-Associated Promyelocytic Leukemia Nuclear Bodies Pathway. PMID:35205052
Exploring the Wnt Pathway as a Therapeutic Target for Prostate Cancer. PMID:35204808
Identifying Mitotic Kinesins as Potential Prognostic Biomarkers in Ovarian Cancer Using Bioinformatic Analyses. PMID:35204562
Vulnerability of Triple-Negative Breast Cancer to Saponin Formosanin C-Induced Ferroptosis. PMID:35204181
Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma. PMID:35203444
Deep analysis of neuroblastoma core regulatory circuitries using online databases and integrated bioinformatics shows their pan-cancer roles as prognostic predictors. PMID:35201514
FAM65A as a novel prognostic biomarker in human tumors reveal by a pan-cancer analysis. PMID:35201499
Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer. PMID:35201488
A Case Series of Metastatic Malignant Gastrointestinal Neuroectodermal Tumors and Comprehensive Genomic Profiling Analysis of 20 Cases. PMID:35200608
Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization. PMID:35197571
Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. PMID:35197475
PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer. PMID:35197445
A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer. PMID:35196489
The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization. PMID:35193494
A Prognostic Model for Acute Myeloid Leukemia Based on IL-2/STAT5 Pathway-Related Genes. PMID:35186733
Identification of Tumor Antigens and Immune Subtypes of Glioblastoma for mRNA Vaccine Development. PMID:35185876
Adult Wilms Tumor: Genetic Evidence of Origin of a Subset of Cases From Metanephric Adenoma. PMID:35184066
New insights on familial colorectal cancer type X syndrome. PMID:35181726
Comprehensive analysis of the expression and significance of CXCLs in human diffuse large B-cell lymphoma. PMID:35181719
PIK3CA co-occurring mutations and copy-number gain in hormone receptor positive and HER2 negative breast cancer. PMID:35181669
Insight into the mitochondrial unfolded protein response and cancer: opportunities and challenges. PMID:35180892
Integrated analysis of the prognostic and oncogenic roles of OPN3 in human cancers. PMID:35180853
RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer. PMID:35179959
Transcriptomic Mapping of Non-Small Cell Lung Cancer K-RAS p.G12C Mutated Tumors: Identification of Surfaceome Targets and Immunologic Correlates. PMID:35178045
Aberrant Expression of ADARB1 Facilitates Temozolomide Chemoresistance and Immune Infiltration in Glioblastoma. PMID:35177985
Tumor stromal nicotinamide N-methyltransferase overexpression as a prognostic biomarker for poor clinical outcome in early-stage colorectal cancer. PMID:35177765
Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition. PMID:35177674
The Genomics of Colorectal Cancer in Populations with African and European Ancestry. PMID:35176763
Overexpressed CMTM6 Improves Prognosis and Associated With Immune Infiltrates of Ovarian Cancer. PMID:35174213
The Mechanism and Prognostic Value of DNA Polymerase δ Subunits in Hepatocellular Carcinoma: Implications for Precision Therapy. PMID:35173474
Identification Prognostic Value and Correlation with Tumor-Infiltrating Immune Cells of Tripartite-Motif Family Genes in Hepatocellular Carcinoma. PMID:35173473
Association between TP53 mutation and high 21-gene recurrence score in estrogen receptor-positive/HER2-negative breast cancer. PMID:35173185
Quantitative profiling of adaptation to cyclin E overproduction. PMID:35173014
Comprehensive pan-cancer analysis on CBX3 as a prognostic and immunological biomarker. PMID:35172803
YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia. PMID:35170430
A gene signature consisting of ubiquitin ligases and deubiquitinating enzymes of SKP2 is associated with clinical outcome in breast cancer. PMID:35169199
ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma. PMID:35167193
A pan-cancer analysis of molecular characteristics and oncogenic role of gasdermins. PMID:35164740
The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells. PMID:35163828
Deciphering Genetic Alterations of Taiwanese Patients with Pancreatic Adenocarcinoma through Targeted Sequencing. PMID:35163506
Whole-Exome Sequencing Identifies a Novel Germline Variant in PTK7 Gene in Familial Colorectal Cancer. PMID:35163215
EVI1 Promotes the Proliferation and Invasive Properties of Human Head and Neck Squamous Cell Carcinoma Cells. PMID:35162973
p53 Promotes Cytokine Expression in Melanoma to Regulate Drug Resistance and Migration. PMID:35159215
Identification of a Gene-Expression-Based Surrogate of Genomic Instability during Oral Carcinogenesis. PMID:35159101
Dissecting TET2 Regulatory Networks in Blood Differentiation and Cancer. PMID:35159097
AKR1B1 as a Prognostic Biomarker of High-Grade Serous Ovarian Cancer. PMID:35159076
Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice. PMID:35159064
New Insights on the Genetics of Pheochromocytoma and Paraganglioma and Its Clinical Implications. PMID:35158861
DNA Methylome Changes of Muscle- and Neuronal-Related Processes Precede Bladder Cancer Invasiveness. PMID:35158756
ITIH5-Derived Polypeptides Covering the VIT Domain Suppress the Growth of Human Cancer Cells In Vitro. PMID:35158755
Identification of Prognostic lncRNA Related to the Immune Microenvironment of Soft Tissue Sarcoma. PMID:35155682
Over-Expression and Prognostic Significance of FATP5, as a New Biomarker, in Colorectal Carcinoma. PMID:35155561
Interpreting Functional Impact of Genetic Variations by Network QTL for Genotype-Phenotype Association Study. PMID:35155440
Prognostic Value and Therapeutic Potential of CBX Family Members in Ovarian Cancer. PMID:35155439
It's Getting Complicated-A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy. PMID:35155432
Comprehensive and Integrative Analysis of Two Novel SARS-CoV-2 Entry Associated Proteases CTSB and CTSL in Healthy Individuals and Cancer Patients. PMID:35155389
Intestinal Stem Cell Marker ASCL2 is a Novel Prognostic Predictor in Esophageal Adenocarcinoma. PMID:35154991
Identification of a Novel Nomogram to Predict Progression Based on the Circadian Clock and Insights Into the Tumor Immune Microenvironment in Prostate Cancer. PMID:35154101
Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer. PMID:35153749
Identification of the Expression and Clinical Significance of E2F Family in Clear Cell Renal Cell Carcinoma. PMID:35153510
Genome Nexus: A Comprehensive Resource for the Annotation and Interpretation of Genomic Variants in Cancer. PMID:35148171
Aberrant somatic hypermutation of CCND1 generates non-coding drivers of mantle cell lymphomagenesis. PMID:35145272
HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer. PMID:35144669
Ten simple rules for large-scale data processing. PMID:35143491
Comprehensive profiling of the TRIpartite motif family to identify pivot genes in hepatocellular carcinoma. PMID:35142083
Cancer and COVID-19 Susceptibility and Severity: A Two-Sample Mendelian Randomization and Bioinformatic Analysis. PMID:35141230
A Novel Prognostic Signature for Survival Prediction and Immune Implication Based on SARS-CoV-2-Related Genes in Kidney Renal Clear Cell Carcinoma. PMID:35141213
An Integrated Pan-Cancer Analysis of 33 Human Cancers Reveals the Potential Clinical Implications and Immunotherapeutic Value of C-X-C Motif Chemokine Ligand 13. PMID:35141160
Pan-Cancer Analyses Reveal Oncogenic Role and Prognostic Value of F-Box Only Protein 22. PMID:35141150
Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. PMID:35140400
A platform for oncogenomic reporting and interpretation. PMID:35140225
Development and validation of a prognostic and predictive 32-gene signature for gastric cancer. PMID:35140202
Ferroptosis‑related long non‑coding RNAs and the roles of LASTR in stomach adenocarcinoma. PMID:35137922
Clinical and molecular assessment of an onco-immune signature with prognostic significance in patients with colorectal cancer. PMID:35137551
The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders. PMID:35136038
Up-regulation of MTHFD2 is associated with clinicopathological characteristics and poor survival in ovarian cancer, possibly by regulating MOB1A signaling. PMID:35135596
As a prognostic biomarker of clear cell renal cell carcinoma RUFY4 predicts immunotherapy responsiveness in a PDL1-related manner. PMID:35135552
[Diagnostic and predictive markers in urinary tract cytology]. PMID:35133495
Chemogenomic and bioinformatic profiling of ERdj paralogs underpins their unique roles in cancer. PMID:35129801
IGF2BP2 maybe a novel prognostic biomarker in oral squamous cell carcinoma. PMID:35129592
Genomic landscape of advanced endometrial cancer analyzed by targeted next-generation sequencing and the cancer genome atlas (TCGA) dataset. PMID:35128859
Toll-Like Receptors Serve as Biomarkers for Early Diagnosis and Prognosis Assessment of Kidney Renal Clear Cell Carcinoma by Influencing the Immune Microenvironment: Comprehensive Bioinformatics Analysis Combined With Experimental Validation. PMID:35127830
Comprehensive Analysis to Identify the Encoded Gens of Sodium Channels as a Prognostic Biomarker in Hepatocellular Carcinoma. PMID:35126466
EFNA3 Is a Prognostic Biomarker Correlated With Immune Cell Infiltration and Immune Checkpoints in Gastric Cancer. PMID:35126464
T cell receptors employ diverse strategies to target a p53 cancer neoantigen. PMID:35124005
When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer. PMID:35123413
Discovery through clinical sequencing in oncology. PMID:35122052
MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination. PMID:35122005
ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation. PMID:35121738
Exploiting the tumor-suppressive activity of the androgen receptor by CDK4/6 inhibition in castration-resistant prostate cancer. PMID:35121110
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients. PMID:35120664
A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma. PMID:35118421
Somatic Mutation Profiles Revealed by Next Generation Sequencing (NGS) in 39 Chinese Hepatocellular Carcinoma Patients. PMID:35118119
COL4A family: potential prognostic biomarkers and therapeutic targets for gastric cancer. PMID:35117889
Identification of biomarkers in colon cancer based on bioinformatic analysis. PMID:35117850
Bioinformatics analysis of BUB1 expression and gene regulation network in lung adenocarcinoma. PMID:35117845
PTPRO predicts patient prognosis and correlates with immune infiltrates in human clear cell renal cell carcinoma. PMID:35117843
KIT/PDGFRA/KDR amplification defines a novel molecular subtype of adenoid cystic carcinoma patients who may benefit from treatment with tyrosine kinase inhibitors. PMID:35117834
High expression of GNB4 predicts poor prognosis in patients with Helicobacter pylori-positive advanced gastric cancer. PMID:35117790
GLUT1/3/4 as novel biomarkers for the prognosis of human breast cancer. PMID:35117597
A comprehensive assessment of the prognostic role of cell adhesion molecules in acute myeloid leukemia. PMID:35117360
Comprehensively analyze the expression and prognostic role for ten-eleven translocations (TETs) in acute myeloid leukemia. PMID:35117329
Epithelial-mesenchymal transition classification of circulating tumor cells in lung and colon cancer patients: potential role in clinical practice. PMID:35117274
Comprehensively investigating the expression levels and the prognostic role of transforming growth factor beta-induced (TGFBI) in glioblastoma multiforme. PMID:35117257
Comprehensive analysis of the NME gene family functions in breast cancer. PMID:35117245
High expression of forkhead box M1 (FOXM1) is a poor prognostic biomarker in lung adenocarcinoma. PMID:35117241
Inflammatory cytokines and alpha-fetoprotein concentrations for predicting survival in patients with hepatocellular carcinoma. PMID:35116917
Overexpression and mutation of ZNF384 is associated with favorable prognosis in breast cancer patients. PMID:35116816
CDCA1/2/3/5/7/8 as novel prognostic biomarkers and CDCA4/6 as potential targets for gastric cancer. PMID:35116645
Systemic characterization of the SLC family genes reveals SLC26A6 as a novel oncogene in hepatocellular carcinoma. PMID:35116598
Bioinformatic analysis of the expression and prognosis of ZNF589 in human breast cancer. PMID:35116546
Low expression of AQP9 and its value in hepatocellular carcinoma. PMID:35116505
A comprehensive bioinformatics analysis to identify a candidate prognostic biomarker for ovarian cancer. PMID:35116478
ADRB2 is a potential protective gene in breast cancer by regulating tumor immune microenvironment. PMID:35116377
A pan-cancer analysis of the oncogenic role of Keratin 17 (KRT17) in human tumors. PMID:35116305
The role of TRIM51 as a multipurpose biomarker in melanoma. PMID:35116291
Molecular Subtyping Resource: a user-friendly tool for rapid biological discovery from transcriptional data. PMID:35112706
Analysis of the effect of NEKs on the prognosis of patients with non-small-cell lung carcinoma based on bioinformatics. PMID:35105934
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation. PMID:35105861
Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer. PMID:35105671
Using Optical Tweezers to Dissect Allosteric Communication Networks in Protein Kinases. PMID:35094342
Comprehensive Analysis of Cell Cycle-Related Genes in Patients With Prostate Cancer. PMID:35087757
Prognostic Significance and Gene Co-Expression Network of PLAU and PLAUR in Gliomas. PMID:35087738
Proteomic profiling of cisplatin-resistant and cisplatin-sensitive germ cell tumour cell lines using quantitative mass spectrometry. PMID:35084545
Development of an Aging-Related Gene Signature for Predicting Prognosis, Immunotherapy, and Chemotherapy Benefits in Rectal Cancer. PMID:35083278
The Age-Specific Features and Clinical Significance of NRF2 and MAPK10 Expression in HCC Patients. PMID:35082522
Modeling Androgen Deprivation Therapy-Induced Prostate Cancer Dormancy and Its Clinical Implications. PMID:35082166
KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas. PMID:35081118
Identification of TIMELESS and RORA as key clock molecules of non-small cell lung cancer and the comprehensive analysis. PMID:35078435
Integrative bioinformatics and experimental analysis revealed TEAD as novel prognostic target for hepatocellular carcinoma and its roles in ferroptosis regulation. PMID:35077390
Let's talk about sex: A biological variable in immune response against melanoma. PMID:35076986
Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT. PMID:35075245
Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer. PMID:35075123
CD274 (PD-L1) Copy Number Changes (Gain) & Response to Immune Checkpoint Blockade Therapy in Carcinomas of the Urinary Tract. PMID:35071713
A comprehensive characterization of the transcriptome in enzalutamide resistance prostate cancer. PMID:35071476
The establishment of a hub differential gene model to predict prognosis in stage II and III right- and left-sided colon cancer patients. PMID:35071457
Prognostic prediction and gene regulation network of EIF2S2 in hepatocellular carcinoma based on data mining. PMID:35070430
Comprehensive analysis of prognostic value and immune infiltration of calpains in pancreatic cancer. PMID:35070391
Identification of Therapeutic Targets and Prognostic Biomarkers among Genes from the Mediator Complex Family in the Hepatocellular Carcinoma Tumour-Immune Microenvironment. PMID:35069777
Pan-Cancer Analysis Revealed SRSF9 as a New Biomarker for Prognosis and Immunotherapy. PMID:35069733
Landscape Analysis of Matrix Metalloproteinases Unveils Key Prognostic Markers for Patients With Breast Cancer. PMID:35069702
Comprehensive Pan-Cancer Genomic Analysis Reveals PHF19 as a Carcinogenic Indicator Related to Immune Infiltration and Prognosis of Hepatocellular Carcinoma. PMID:35069553
Classification of bladder cancer cell lines according to regulon activity. PMID:35068946
Association of genomic profiles and survival in early onset and screening-age colorectal cancer patients with liver metastases resected over 15 years. PMID:35066881
High expression of PDZ-binding kinase is correlated with poor prognosis and immune infiltrates in hepatocellular carcinoma. PMID:35065633
Prognostic Value and Immune Infiltration Analysis of Nuclear Factor Erythroid-2 Family Members in Ovarian Cancer. PMID:35059466
Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers. PMID:35058360
Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer. PMID:35054819
High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients. PMID:35053500
Genetic Alterations in Mitochondrial DNA Are Complementary to Nuclear DNA Mutations in Pheochromocytomas. PMID:35053433
Onco-miR-21 Promotes Stat3-Dependent Gastric Cancer Progression. PMID:35053428
The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors. PMID:35049682
The association between bromodomain proteins and cancer stemness in different solid tumor types. PMID:35049055
Probing altered enzyme activity in the biochemical characterization of cancer. PMID:35048115
The dominant TP53 hotspot mutation in IDH -mutant astrocytoma, R273C, has distinctive pathologic features and sex-specific prognostic implications. PMID:35047821
Expression of TIMPs and MMPs in Ovarian Tumors, Ascites, Ascites-Derived Cells, and Cancer Cell Lines: Characteristic Modulatory Response Before and After Chemotherapy Treatment. PMID:35047406
Comprehensive Analysis of Expression, Prognostic Value, and Immune Infiltration for Ubiquitination-Related FBXOs in Pancreatic Ductal Adenocarcinoma. PMID:35046938
The path to the clinic: a comprehensive review on direct KRASG12C inhibitors. PMID:35045886
Enhancing Radioiodine Incorporation in BRAF-Mutant, Radioiodine-Refractory Thyroid Cancers with Vemurafenib and the Anti-ErbB3 Monoclonal Antibody CDX-3379: Results of a Pilot Clinical Trial. PMID:35045748
Primary tumour immune response and lymph node yields in colon cancer. PMID:35043009
Primary lung cancer in women after previous breast cancer. PMID:35040941
MiR-378a inhibits glucose metabolism by suppressing GLUT1 in prostate cancer. PMID:35039635
Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover. PMID:35033184
The functions and prognostic value of Krüppel-like factors in breast cancer. PMID:35033064
The modifying enzyme Tsr3 establishes the hierarchy of Rio kinase binding in 40S ribosome assembly. PMID:35031584
Calcium selective channel TRPV6: Structure, function, and implications in health and disease. PMID:35031425
How can same-gene mutations promote both cancer and developmental disorders? PMID:35030014
Promising novel biomarkers and candidate small-molecule drugs for lung adenocarcinoma: Evidence from bioinformatics analysis of high-throughput data. PMID:35028418
HBXIP induces anoikis resistance by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis and stabilize Prdx1 in breast cancer. PMID:35027562
EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22. PMID:35025968
The clinicopathological and molecular characteristics of resected EGFR-mutant lung adenocarcinoma. PMID:35023616
Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma. PMID:35022408
2-Hydroxyglutarate destabilizes chromatin regulatory landscape and lineage fidelity to promote cellular heterogeneity. PMID:35021081
BCL3 expression is strongly associated with the occurrence of breast cancer relapse under tamoxifen treatment in a retrospective cohort study. PMID:35020071
Truncating CDKN1A mutations: an insight into the biology of urinary tract carcinomas? PMID:35018253
Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast. PMID:35013309
Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer. PMID:35013121
PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer. PMID:35013112
A Role for ER-Beta in the Effects of Low-Density Lipoprotein Cholesterol and 27-Hydroxycholesterol on Breast Cancer Progression: Involvement of the IGF Signalling Pathway? PMID:35011656
RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival. PMID:35008922
Neurofibromatosis Type 1 Gene Alterations Define Specific Features of a Subset of Glioblastomas. PMID:35008787
A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members. PMID:35008511
Bak and Bcl-xL Participate in Regulating Sensitivity of Solid Tumor Derived Cell Lines to Mcl-1 Inhibitors. PMID:35008345
The role of distinct co-mutation patterns with TP53 mutation in immunotherapy for NSCLC. PMID:35005121
Transcriptomic profiling of peroxisome-related genes reveals a novel prognostic signature in hepatocellular carcinoma. PMID:35005112
High Expression of Glycolytic Genes in Clinical Glioblastoma Patients Correlates With Lower Survival. PMID:35004842
Downregulated ADARB1 Facilitates Cell Proliferation, Invasion and has Effect on the Immune Regulation in Ovarian Cancer. PMID:35004651
CDKN2A Deletion Leading to Hematogenous Metastasis of Human Gastric Carcinoma. PMID:35004325
Comprehensive Analysis of the Prognostic Values of the TRIM Family in Hepatocellular Carcinoma. PMID:35004288
oCEM: Automatic detection and analysis of overlapping co-expressed gene modules. PMID:34998362
Genomic studies controvert the existence of the CUX1 p75 isoform. PMID:34997000
Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights. PMID:34996497
Identification of high protein kinase CK2α in HPV(+) oropharyngeal squamous cell carcinoma and correlation with clinical outcomes. PMID:34993017
The Circadian Gene NPAS2 Act as a Putative Tumor Stimulative Factor for Uterine Corpus Endometrial Carcinoma. PMID:34992456
MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling. PMID:34992146
Systematic analysis of the role of SLC52A2 in multiple human cancers. PMID:34991609
YAP1 and PRDM14 converge to promote cell survival and tumorigenesis. PMID:34990589
Metabolite profiling reveals a connection between aldehyde dehydrogenase 1A3 and GABA metabolism in breast cancer metastasis. PMID:34989902
Retinoblastoma protein regulates carcinogen susceptibility at heterochromatic cancer driver loci. PMID:34983823
rAAV-delivered PTEN therapeutics for prostate cancer. PMID:34976432
Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics. PMID:34976316
The diagnostic and prognostic significance of small nuclear ribonucleoprotein Sm D1 aberrantly high expression in hepatocellular carcinoma. PMID:34976182
Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway. PMID:34975329
Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis. PMID:34973624
CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop. PMID:34971802
Glycogenes in Oncofetal Chondroitin Sulfate Biosynthesis are Differently Expressed and Correlated With Immune Response in Placenta and Colorectal Cancer. PMID:34966741
Role of the CBX Molecular Family in Lung Adenocarcinoma Tumorigenesis and Immune Infiltration. PMID:34966411
Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer. PMID:34964699
The ncRNA-Mediated Overexpression of Ferroptosis-Related Gene EMC2 Correlates With Poor Prognosis and Tumor Immune Infiltration in Breast Cancer. PMID:34956895
LINC00467, Driven by Copy Number Amplification and DNA Demethylation, Is Associated with Oxidative Lipid Metabolism and Immune Infiltration in Breast Cancer. PMID:34956437
p53 Immunohistochemistry Patterns Are Surrogate Biomarkers for TP53 Mutations in Gastrointestinal Neuroendocrine Neoplasms. PMID:34956360
A β-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer. PMID:34954189
Multi-omics of the expression and clinical outcomes of TMPRSS2 in human various cancers: A potential therapeutic target for COVID-19. PMID:34951103
Comprehensive Analysis of the Effects of Genetic Ancestry and Genetic Characteristics on the Clinical Evolution of Oral Squamous Cell Carcinoma. PMID:34950653
KDM6 Demethylases and Their Roles in Human Cancers. PMID:34950587
High Frequency of Juxtamembrane Domain ERBB2 Mutation in Gastric Cancer. PMID:34949663
MicroRNAs Regulate Cell Cycle and Cell Death Pathways in Glioblastoma. PMID:34948346
Nuclear RNA Exosome and Pervasive Transcription: Dual Sculptors of Genome Function. PMID:34948199
Pharmacological Inhibition of Sonic Hedgehog Signaling Suppresses Tumor Development in a Murine Model of Intrahepatic Cholangiocarcinoma. PMID:34948011
µ-Crystallin Is Associated with Disease Outcome in Head and Neck Squamous Cell Carcinoma. PMID:34945802
Insights of RKIP-Derived Suppression of Prostate Cancer. PMID:34945007
Carnitine Palmitoyltransferase 1 Regulates Prostate Cancer Growth under Hypoxia. PMID:34944922
Transcription Regulation and Genome Rewiring Governing Sensitivity and Resistance to FOXM1 Inhibition in Breast Cancer. PMID:34944900
YB1 Is a Major Contributor to Health Disparities in Triple Negative Breast Cancer. PMID:34944882
Loss of microRNA-135b Enhances Bone Metastasis in Prostate Cancer and Predicts Aggressiveness in Human Prostate Samples. PMID:34944822
miR-154 Influences HNSCC Development and Progression through Regulation of the Epithelial-to-Mesenchymal Transition Process and Could Be Used as a Potential Biomarker. PMID:34944712
Rapid Androgen-Responsive Proteome Is Involved in Prostate Cancer Progression. PMID:34944692
Novel Insights into the Prognosis and Immunological Value of the SLC35A (Solute Carrier 35A) Family Genes in Human Breast Cancer. PMID:34944621
Exploring the Value of BRD9 as a Biomarker, Therapeutic Target and Co-Target in Prostate Cancer. PMID:34944438
Gene Expression Profiles Identify Biomarkers of Resistance to Decitabine in Myelodysplastic Syndromes. PMID:34944006
TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in Triple-Negative Breast Cancer. PMID:34943938
Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis. PMID:34941867
An integrative pan-cancer analysis reveals the oncogenic role of mutS homolog 6 (MSH6) in human tumors. PMID:34941572
Expression and Clinical Significance of Novel Long Noncoding RNA Fibroblast Growth Factor 10AS and FGF10 in Colorectal Cancer. PMID:34939760
IRF7 is a Prognostic Biomarker and Associated with Immune Infiltration in Stomach Adenocarcinoma. PMID:34938108
Prognostic biomarker SMARCC1 and its association with immune infiltrates in hepatocellular carcinoma. PMID:34937564
Druggable genetic targets in endometrial cancer✰,✰✰. PMID:34933203
FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer. PMID:34932854
The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells. PMID:34930366
cbpManager: a web application to streamline the integration of clinical and genomic data in cBioPortal to support the Molecular Tumor Board. PMID:34930224
Identification of the Prognostic Value Among Suppressor Of Cytokine Signaling Family Members in Kidney Renal Clear Cell Carcinoma. PMID:34926570
Pan-Cancer Analysis of the Solute Carrier Family 39 Genes in Relation to Oncogenic, Immune Infiltrating, and Therapeutic Targets. PMID:34925450
Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation. PMID:34922480
KRAS mutation-independent downregulation of MAPK/PI3K signaling in colorectal cancer. PMID:34919787
Cancer-derived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart. PMID:34918105
Identification of a Lipid Metabolism-Associated Gene Signature Predicting Survival in Breast Cancer. PMID:34916832
Identification of the Nerve-Cancer Cross-Talk-Related Prognostic Gene Model in Head and Neck Squamous Cell Carcinoma. PMID:34912722
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. PMID:34910928
Epidermal Integrin α3β1 Regulates Tumor-Derived Proteases BMP-1, Matrix Metalloprotease-9, and Matrix Metalloprotease-3. PMID:34909716
Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics. PMID:34900668
A Network-Centric Framework for the Evaluation of Mutual Exclusivity Tests on Cancer Drivers. PMID:34899838
Exploring the Prognostic Value, Immune Implication and Biological Function of H2AFY Gene in Hepatocellular Carcinoma. PMID:34899687
SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer. PMID:34893760
Identification of prognostic and therapeutic value of CC chemokines in Urothelial bladder cancer: evidence from comprehensive bioinformatic analysis. PMID:34893045
MLL4 mediates differentiation and tumor suppression through ferroptosis. PMID:34890228
A Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF1. PMID:34888238
NF-Y subunits overexpression in gastric adenocarcinomas (STAD). PMID:34887475
Mismatch Repair Deficiency and Somatic Mutations in Human Sinonasal Tumors. PMID:34885191
An Observational Study on the Molecular Profiling of Primary Melanomas Reveals a Progression Dependence on Mitochondrial Activation. PMID:34885173
Pathogen-Induced Epigenetic Modifications in Cancers: Implications for Prevention, Detection and Treatment of Cancers in Africa. PMID:34885162
Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma. PMID:34885146
Stromal Cells Promote Matrix Deposition, Remodelling and an Immunosuppressive Tumour Microenvironment in a 3D Model of Colon Cancer. PMID:34885111
MiR-195 and Its Target SEMA6D Regulate Chemoresponse in Breast Cancer. PMID:34885090
Gene Expression in Barrett's Esophagus Cell Lines Resemble Esophageal Squamous Cell Carcinoma Instead of Esophageal Adenocarcinoma. PMID:34885081
DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review. PMID:34884835
Targeting Oncogenic Transcriptional Networks in Neuroblastoma: From N-Myc to Epigenetic Drugs. PMID:34884690
PRRC2A Promotes Hepatocellular Carcinoma Progression and Associates with Immune Infiltration. PMID:34881207
Bioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer. PMID:34880657
SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects. PMID:34879275
Landscape of the oncogenic role of fatty acid synthase in human tumors. PMID:34879004
Comprehensive Analysis of LPCATs Highlights the Prognostic and Immunological Values of LPCAT1/4 in Hepatocellular Carcinoma. PMID:34876845
Characterization of the GATA Transcription Factor Family and Exploration of Their Relevance to Immune Infiltration and Tumor Microenvironment in Pancreatic Cancer. PMID:34876843
A computational approach for the discovery of significant cancer genes by weighted mutation and asymmetric spreading strength in networks. PMID:34876593
Detection of gene mutations and gene-gene fusions in circulating cell-free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis. PMID:34875133
Branching clonal evolution patterns predominate mutational landscape in multiple myeloma. PMID:34873486
A radiogenomics application for prognostic profiling of endometrial cancer. PMID:34873276
The pattern of alternative splicing in lung adenocarcinoma shows novel events correlated with tumorigenesis and immune microenvironment. PMID:34872548
Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets. PMID:34871816
Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells. PMID:34871431
Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells. PMID:34871413
The ReIMAGINE Multimodal Warehouse: Using Artificial Intelligence for Accurate Risk Stratification of Prostate Cancer. PMID:34870187
Methylation and Expression of the Exercise-Related TLR1 Gene Is Associated With Low Grade Glioma Prognosis and Outcome. PMID:34869584
Clinical Significance and Prognostic Value of Human Soluble Resistance-Related Calcium-Binding Protein: A Pan-Cancer Analysis. PMID:34869449
Deciphering CHFR Role in Pancreatic Ductal Adenocarcinoma. PMID:34869418
Comprehensive Analysis and Identification of Prognostic Biomarkers and Therapeutic Targets Among FAM83 Family Members for Gastric Cancer. PMID:34869310
Identification and Validation of an 6-Metabolism-Related Gene Signature and Its Correlation With Immune Checkpoint in Hepatocellular Carcinoma. PMID:34869039
OLFML2B Is a Robust Prognostic Biomarker in Bladder Cancer Through Genome-Wide Screening: A Study Based on Seven Cohorts. PMID:34868901
Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma. PMID:34863298
From biobank and data silos into a data commons: convergence to support translational medicine. PMID:34863191
Chromosome Missegregation as a Modulator of Radiation Sensitivity. PMID:34861996
Impact of TP53 Genomic Alterations in Large B-Cell Lymphoma Treated With CD19-Chimeric Antigen Receptor T-Cell Therapy. PMID:34860572
Omics- and Pharmacogenomic Evidence for the Prognostic, Regulatory, and Immune-Related Roles of PBK in a Pan-Cancer Cohort. PMID:34859058
Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC. PMID:34858826
Clinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine. PMID:34858045
Calcium sensing receptor stimulates breast cancer cell migration via the Gβγ-AKT-mTORC2 signaling pathway. PMID:34854057
CCL20 induces colorectal cancer neoplastic epithelial cell proliferation, migration, and further CCL20 production through autocrine HGF-c-Met and MSP-MSPR signaling pathways. PMID:34853656
Emergence of mTOR mutation as an acquired resistance mechanism to AKT inhibition, and subsequent response to mTORC1/2 inhibition. PMID:34853384
Real-World Approach for Molecular Analysis of Acquired EGFR Tyrosine Kinase Inhibitor Resistance Mechanisms in NSCLC. PMID:34849493
Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model. PMID:34849464
SKA3 Serves as a Biomarker for Poor Prognosis in Kidney Renal Papillary Cell Carcinoma. PMID:34849004
In vivo optical imaging-guided targeted sampling for precise diagnosis and molecular pathology. PMID:34848749
Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma. PMID:34848557
Molecular, clinical, and prognostic implications of PTPN11 mutations in acute myeloid leukemia. PMID:34847232
Integrative analysis of prognostic value and immune infiltration of spindle and kinetochore-associated family members in breast cancer. PMID:34845974
Genetic and epigenetic regulation of the NRF2-KEAP1 pathway in human lung cancer. PMID:34845361
Selective KRAS G12C inhibitors in non-small cell lung cancer: chemistry, concurrent pathway alterations, and clinical outcomes. PMID:34845311
The NUCKS1-SKP2-p21/p27 axis controls S phase entry. PMID:34845229
The N6-Methyladenosine- (m6A-) Associated Genes Act as Strong Key Biomarkers for the Prognosis of Pancreatic Adenocarcinoma. PMID:34840598
Genomic mutation features identify distinct BRCA-associated mutation characteristics in endometrioid carcinoma and endometrioid ovarian carcinoma. PMID:34837690
Bioinformatics Analysis Identifies Precision Treatment with Paclitaxel for Hepatocellular Carcinoma Patients Harboring Mutant TP53 or Wild-Type CTNNB1 Gene. PMID:34834551
Reciprocal Regulation of Hippo and WBP2 Signalling-Implications in Cancer Therapy. PMID:34831354
EphA2 Expression in Bone Sarcomas: Bioinformatic Analyses and Preclinical Characterization in Patient-Derived Models of Osteosarcoma, Ewing's Sarcoma and Chondrosarcoma. PMID:34831119
Melanoma Targeted Therapies beyond BRAF-Mutant Melanoma: Potential Druggable Mutations and Novel Treatment Approaches. PMID:34831002
Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer. PMID:34830941
Cyclin E1 in Murine and Human Liver Cancer: A Promising Target for Therapeutic Intervention during Tumour Progression. PMID:34830835
Patient-Specific Modeling of Diffuse Large B-Cell Lymphoma. PMID:34829885
Identification of NSP3 (SH2D3C) as a Prognostic Biomarker of Tumor Progression and Immune Evasion for Lung Cancer and Evaluation of Organosulfur Compounds from Allium sativum L. as Therapeutic Candidates. PMID:34829812
RANK-C Expression Sensitizes ER-Negative, EGFR-Positive Breast Cancer Cells to EGFR-Tyrosine Kinase Inhibitors (TKIs). PMID:34828291
Molecular and Clinical Characterization of a Novel Prognostic and Immunologic Biomarker GPSM3 in Low-Grade Gliomas. PMID:34827528
A ubiquitous disordered protein interaction module orchestrates transcription elongation. PMID:34822292
Efficacy of Targeted Inhibitors in Metastatic Lung Squamous Cell Carcinoma With EGFR or ALK Alterations. PMID:34820641
Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells. PMID:34820606
KRAS A146 Mutations Are Associated With Distinct Clinical Behavior in Patients With Colorectal Liver Metastases. PMID:34820593
The role of complement in the clinical course of hepatocellular carcinoma. PMID:34813686
TMPRSS4 promotes cancer stem-like properties in prostate cancer cells through upregulation of SOX2 by SLUG and TWIST1. PMID:34809669
Genome-wide DNA methylation analysis of pulmonary function in middle and old-aged Chinese monozygotic twins. PMID:34809630
RETSAT Mutation Selected for Hypoxia Adaptation Inhibits Tumor Growth. PMID:34805153
Mitotic Errors Promote Genomic Instability and Leukemia in a Novel Mouse Model of Fanconi Anemia. PMID:34804941
Comprehensive Analysis of m6A RNA Methylation Regulators in the Prognosis and Immune Microenvironment of Multiple Myeloma. PMID:34804925
The Integrative Analysis of Thrombospondin Family Genes in Pan-Cancer Reveals that THBS2 Facilitates Gastrointestinal Cancer Metastasis. PMID:34804159
Prognostic Values and Clinical Significance of S100 Family Member's Individualized mRNA Expression in Pancreatic Adenocarcinoma. PMID:34804125
Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer. PMID:34804118
Comprehensive Analysis of m6A RNA Methylation Regulators and the Immune Microenvironment to Aid Immunotherapy in Pancreatic Cancer. PMID:34804059
Two distinct mechanisms underlie estrogen-receptor-negative breast cancer susceptibility at the 2p23.2 locus. PMID:34803163
Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer. PMID:34802033
Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma. PMID:34799547
Hsa-miR-21-3p associates with breast cancer patient survival and targets genes in tumor suppressive pathways. PMID:34797887
Glia Maturation Factor Beta as a Novel Biomarker and Therapeutic Target for Hepatocellular Carcinoma. PMID:34796110
Role of FRG1 in predicting the overall survivability in cancers using multivariate based optimal model. PMID:34795329
Dynamic expression of SNAI2 in prostate cancer predicts tumor progression and drug sensitivity. PMID:34792282
SLC7A5 is linked to increased expression of genes related to proliferation and hypoxia in estrogen‑receptor‑positive breast cancer. PMID:34792178
The F-box protein, FBXO7, is required to maintain chromosome stability in humans. PMID:34791250
Expression and prognosis of the B7 family in acute myeloid leukemia. PMID:34790736
Low Expression of SLC7A11 Confers Drug Resistance and Worse Survival in Ovarian Cancer via Inhibition of Cell Autophagy as a Competing Endogenous RNA. PMID:34790572
Prognostic and immune infiltrates for the Chromobox (CBX) protein family in human pancreatic adenocarcinoma. PMID:34790394
Comprehensive bioinformatics analyses identified Homeobox B9 as a potential prognostic biomarker and therapeutic target for gastric cancer. PMID:34790380
A Cholesterol Homeostasis-Related Gene Signature Predicts Prognosis of Endometrial Cancer and Correlates With Immune Infiltration. PMID:34790227
Role of Rho guanine nucleotide exchange factors in non-small cell lung cancer. PMID:34783629
Clinical and genomic features of SPOP-mutant prostate cancer. PMID:34783071
Discovery proteomics defines androgen-regulated glycoprotein networks in prostate cancer cells, as well as putative biomarkers of prostatic diseases. PMID:34782677
Genomic Alterations in Human Papillomavirus-Positive and -Negative Conjunctival Squamous Cell Carcinomas. PMID:34779821
ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer. PMID:34779768
Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma. PMID:34779417
Radioresistance of Human Cancers: Clinical Implications of Genetic Expression Signatures. PMID:34778082
Roles of HMGBs in Prognosis and Immunotherapy: A Pan-Cancer Analysis. PMID:34777483
CTNNB1 Alternation Is a Potential Biomarker for Immunotherapy Prognosis in Patients With Hepatocellular Carcinoma. PMID:34777372
CSNK2 in cancer: pathophysiology and translational applications. PMID:34773100
Mutant p53 elicits context-dependent pro-tumorigenic phenotypes. PMID:34773073
The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes. PMID:34772942
Papillary Thyroid Cancer Prognosis: An Evolving Field. PMID:34771729
Drug Repositioning Based on the Reversal of Gene Expression Signatures Identifies TOP2A as a Therapeutic Target for Rectal Cancer. PMID:34771654
Genomic Instability of Circulating Tumor DNA as a Prognostic Marker for Pancreatic Cancer Survival: A Prospective Cohort Study. PMID:34771630
Clinical Value of NGS Genomic Studies for Clinical Management of Pediatric and Young Adult Bone Sarcomas. PMID:34771600
Androgen Receptor Signaling in Prostate Cancer and Therapeutic Strategies. PMID:34771580
The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors. PMID:34769213
The Impact of ZIP8 Disease-Associated Variants G38R, C113S, G204C, and S335T on Selenium and Cadmium Accumulations: The First Characterization. PMID:34768831
Systematic Analysis of FASTK Gene Family Alterations in Cancer. PMID:34768773
Alternative polyadenylation: An untapped source for prostate cancer biomarkers and therapeutic targets? PMID:34765448
RAB11FIP1: An Indicator for Tumor Immune Microenvironment and Prognosis of Lung Adenocarcinoma from a Comprehensive Analysis of Bioinformatics. PMID:34764984
Integrative Bioinformatics approaches to therapeutic gene target selection in various cancers for Nitroglycerin. PMID:34764329
Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells. PMID:34764293
TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma. PMID:34764231
TAp63 regulates bone remodeling by modulating the expression of TNFRSF11B/Osteoprotegerin. PMID:34763601
A comprehensive analysis of prefoldins and their implication in cancer. PMID:34761191
H2AFZ Is a Prognostic Biomarker Correlated to TP53 Mutation and Immune Infiltration in Hepatocellular Carcinoma. PMID:34760688
The Prognostic and Immunological Value of Guanylate-Binding Proteins in Lower-Grade Glioma: Potential Markers or Not? PMID:34759950
The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression. PMID:34758724
Identification of SLITRK6 as a Novel Biomarker in hepatocellular carcinoma by comprehensive bioinformatic analysis. PMID:34754951
Functional drug-target-disease network analysis of gene-phenotype connectivity for curcumin in hepatocellular carcinoma. PMID:34754622
A Pan-Cancer Analysis of the Role of Selenoprotein P mRNA in Tumorigenesis. PMID:34754222
Ferroptosis Characterization in Lung Adenocarcinomas Reveals Prognostic Signature With Immunotherapeutic Implication. PMID:34746138
HPV-Related Promoter Methylation-Based Gene Signature Predicts Clinical Prognosis of Patients With Cervical Cancer. PMID:34745985
Re-Identification of Patient Subgroups in Uveal Melanoma. PMID:34745953
Comprehensive Analysis of IGFBPs as Biomarkers in Gastric Cancer. PMID:34745945
Knockdown of LMTK3 in the Endometrioid Adenocarcinoma Cell Line Ishikawa: Inhibition of Growth and Estrogen Receptor α. PMID:34745935
Recognition of DNA Methylation Molecular Features for Diagnosis and Prognosis in Gastric Cancer. PMID:34745226
ZWINT is a Promising Therapeutic Biomarker Associated with the Immune Microenvironment of Hepatocellular Carcinoma. PMID:34744456
Androgen deprivation‑induced OPHN1 amplification promotes castration‑resistant prostate cancer. PMID:34738630
CDCA7 Facilitates Tumor Progression by Directly Regulating CCNA2 Expression in Esophageal Squamous Cell Carcinoma. PMID:34737951
Identification of ABCC5 Among ATP-Binding Cassette Transporter Family as a New Biomarker for Hepatocellular Carcinoma Based on Bioinformatics Analysis. PMID:34737618
Integrated miRNA-mRNA Expression Profiles Revealing Key Molecules in Ovarian Cancer Based on Bioinformatics Analysis. PMID:34734085
ARHGAP11A Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric Cancer. PMID:34733886
Comprehensive Analysis of Regulatory Factors and Immune-Associated Patterns to Decipher Common and BRCA1/2 Mutation-Type-Specific Critical Regulation in Breast Cancer. PMID:34733851
Prognostic and tumor-immune infiltration cell signatures in tamoxifen-resistant breast cancers. PMID:34733726
Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3. PMID:34733461
Allele-specific genomic data elucidate the role of somatic gain and copy-number neutral loss of heterozygosity in cancer. PMID:34731645
Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. PMID:34731610
Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription. PMID:34731603
The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma. PMID:34731180
Integrated analysis of expression, prognostic value and immune infiltration of GSDMs in hepatocellular carcinoma. PMID:34731088
ParsVNN: parsimony visible neural networks for uncovering cancer-specific and drug-sensitive genes and pathways. PMID:34729476
Comprehensive Analysis of the Expression of TGF-β Signaling Regulators and Prognosis in Human Esophageal Cancer. PMID:34725559
A mixture model for signature discovery from sparse mutation data. PMID:34724984
Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing. PMID:34724198
SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values. PMID:34722629
OncoDB: an interactive online database for analysis of gene expression and viral infection in cancer. PMID:34718715
RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs. PMID:34718714
EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers. PMID:34718348
Gut-derived lipopolysaccharide remodels tumoral microenvironment and synergizes with PD-L1 checkpoint blockade via TLR4/MyD88/AKT/NF-κB pathway in pancreatic cancer. PMID:34718325
Dopamine and dopamine receptor D1 as a novel favourable biomarker for hepatocellular carcinoma. PMID:34717619
T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma. PMID:34717036
The role of PI3'-lipid signalling in melanoma initiation, progression and maintenance. PMID:34717019
CMAHP promotes metastasis by reducing ubiquitination of Snail and inducing angiogenesis via GM-CSF overexpression in gastric cancer. PMID:34716430
Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse. PMID:34716314
Detection of PKD1 and PKD2 Somatic Variants in Autosomal Dominant Polycystic Kidney Cyst Epithelial Cells by Whole-Genome Sequencing. PMID:34716216
PRCC reduces the sensitivity of cancer cells to DNA damage by inhibiting JNK and ATM/ATR pathways and results in a poor prognosis in hepatocellular carcinoma. PMID:34715922
Integrins regulate stemness in solid tumor: an emerging therapeutic target. PMID:34715893
MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer. PMID:34712921
TNFSF13 Is a Novel Onco-Inflammatory Marker and Correlates With Immune Infiltration in Gliomas. PMID:34712225
Oncogene-mediated metabolic gene signature predicts breast cancer outcome. PMID:34711841
Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation. PMID:34711823
Massive parallel sequencing in individuals with multiple primary tumours reveals the benefit of re-analysis. PMID:34711244
NCF1/2/4 Are Prognostic Biomarkers Related to the Immune Infiltration of Kidney Renal Clear Cell Carcinoma. PMID:34708124
Comprehensive Analysis of Aquaporin Superfamily in Lung Adenocarcinoma. PMID:34708074
Analysing a Novel RNA-Binding-Protein-Related Prognostic Signature Highly Expressed in Breast Cancer. PMID:34707800
CD47 (Cluster of Differentiation 47). PMID:34707698
Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence. PMID:34706158
Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-β-catenin-driven M2 macrophage. PMID:34703882
Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers. PMID:34702252
PIM1 phosphorylation of the androgen receptor and 14-3-3 ζ regulates gene transcription in prostate cancer. PMID:34697370
Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway. PMID:34693224
Identification of Candidate Biomarker ASXL2 and Its Predictive Value in Pancreatic Carcinoma. PMID:34692512
Identification of C3 and FN1 as potential biomarkers associated with progression and prognosis for clear cell renal cell carcinoma. PMID:34688260
Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma. PMID:34687603
Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction. PMID:34686865
Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis. PMID:34686346
Prognostic Significance of Dysregulated Epigenomic and Chromatin Modifiers in Cervical Cancer. PMID:34685645
Distinct Clinical Impact and Biological Function of Angiopoietin and Angiopoietin-like Proteins in Human Breast Cancer. PMID:34685578
Integrated Molecular Characterization to Reveal the Association between Kynurenine 3-Monooxygenase Expression and Tumorigenesis in Human Breast Cancers. PMID:34683090
Prognostic Value of Interleukin-32 Expression and Its Correlation with the Infiltration of Natural Killer Cells in Cutaneous Melanoma. PMID:34682815
Identification of Tumor Antigens in Ovarian Cancers Using Local and Circulating Tumor-Specific Antibodies. PMID:34681879
The Intrinsically Disordered Region in the Human STN1 OB-Fold Domain Is Important for Protecting Genome Stability. PMID:34681076
DBtRend: A Web-Server of tRNA Expression Profiles from Small RNA Sequencing Data in Humans. PMID:34680971
Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas. PMID:34680577
Clinically Translatable Approaches of Inhibiting TGF-β to Target Cancer Stem Cells in TNBC. PMID:34680503
Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer. PMID:34680446
Precision Oncology of High-Grade Ovarian Cancer Defined through Targeted Sequencing. PMID:34680387
Comprehensive Analysis of VEGFR2 Expression in HPV-Positive and -Negative OPSCC Reveals Differing VEGFR2 Expression Patterns. PMID:34680369
Molecular Signature Expands the Landscape of Driver Negative Thyroid Cancers. PMID:34680332
Prognostic Gene Signature for Squamous Cell Carcinoma with a Higher Risk for Treatment Failure and Accelerated MEK-ERK Pathway Activity. PMID:34680330
A Systems Approach to Interrogate Gene Expression Patterns in African American Men Presenting with Clinically Localized Prostate Cancer. PMID:34680291
EGFR Exon 20 Insertion in Metastatic Non-Small-Cell Lung Cancer: Survival and Clinical Efficacy of EGFR Tyrosine-Kinase Inhibitor and Chemotherapy. PMID:34680280
Pirfenidone Reduces Epithelial-Mesenchymal Transition and Spheroid Formation in Breast Carcinoma through Targeting Cancer-Associated Fibroblasts (CAFs). PMID:34680267
Frequent Epigenetic Inactivation of DIRAS-1 and DIRAS-2 Contributes to Chemo-Resistance in Gliomas. PMID:34680261
The Evolution of Clinically Aggressive Triple-Negative Breast Cancer Shows a Large Mutational Diversity and Early Metastasis to Lymph Nodes. PMID:34680239
An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors. PMID:34676262
Integrative Analysis of Metallothioneins Identifies MT1H as Candidate Prognostic Biomarker in Hepatocellular Carcinoma. PMID:34676244
Luminescence complementation technology for the identification of MYC:TRRAP inhibitors. PMID:34676047
The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor. PMID:34674701
Targeting Long Non-Coding RNA TTN-AS1 Suppresses Bladder Cancer Progression. PMID:34671381
AML with germline DDX41 variants is a clinicopathologically distinct entity with an indolent clinical course and favorable outcome. PMID:34671111
Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression. PMID:34670568
Copy number variation analysis of m6 A regulators identified METTL3 as a prognostic and immune-related biomarker in bladder cancer. PMID:34668652
Prognostic implications of epidermal and platelet-derived growth factor receptor alterations in 2 cohorts of IDHwt glioblastoma. PMID:34667950
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis. PMID:34664408
Development of a KRAS-Associated Metabolic Risk Model for Prognostic Prediction in Pancreatic Cancer. PMID:34660806
The Effect of Smoking on the Immune Microenvironment and Immunogenicity and Its Relationship With the Prognosis of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer. PMID:34660603
A prognostic score based on long-term survivor unique transcriptomic signatures predicts patient survival in pancreatic ductal adenocarcinoma. PMID:34659888
Overexpression of P4HA1 associates with poor prognosis and promotes cell proliferation and metastasis of lung adenocarcinoma. PMID:34659558
FAM83A Promotes the Proliferative and Invasive Abilities of Cervical Cancer Cells via Epithelial-Mesenchymal Transition and the Wnt Signaling Pathway. PMID:34659522
M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way. PMID:34656164
Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation. PMID:34656143
EZH2 inhibition confers PIK3CA-driven lung tumors enhanced sensitivity to PI3K inhibition. PMID:34655667
DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes. PMID:34654425
C/EBPβ induces B-cell acute lymphoblastic leukemia and cooperates with BLNK mutations. PMID:34653294
Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma. PMID:34651586
The Expression Patterns and Prognostic Value of the Proteasome Activator Subunit Gene Family in Gastric Cancer Based on Integrated Analysis. PMID:34650966
Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers. PMID:34649609
Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma. PMID:34649520
The human GID complex engages two independent modules for substrate recruitment. PMID:34647674
Cancer gene mutation frequencies for the U.S. population. PMID:34645806
EFNA3 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with lung adenocarcinoma. PMID:34645436
Stat1 confers sensitivity to radiation in cervical cancer cells by controlling Parp1 levels: a new perspective for Parp1 inhibition. PMID:34642300
The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism. PMID:34638814
MET Amplification in Non-Small Cell Lung Cancer (NSCLC)-A Consecutive Evaluation Using Next-Generation Sequencing (NGS) in a Real-World Setting. PMID:34638507
TBX2 Drives Neuroendocrine Prostate Cancer through Exosome-Mediated Repression of miR-200c-3p. PMID:34638504
Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity. PMID:34638503
Potential Therapeutic and Prognostic Values of LSM Family Genes in Breast Cancer. PMID:34638387
Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate Cancer. PMID:34638338
Low Levels of TRIM28-Interacting KRAB-ZNF Genes Associate with Cancer Stemness and Predict Poor Prognosis of Kidney Renal Clear Cell Carcinoma Patients. PMID:34638319
Targeted Sequencing Revealed Distinct Mutational Profiles of Ocular and Extraocular Sebaceous Carcinomas. PMID:34638295
The Role of the Hedgehog Pathway in Cholangiocarcinoma. PMID:34638259
Overcoming Immunotherapy Resistance by Targeting the Tumor-Intrinsic NLRP3-HSP70 Signaling Axis. PMID:34638239
The Landscape of Transmembrane Protein Family Members in Head and Neck Cancers: Their Biological Role and Diagnostic Utility. PMID:34638224
Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters. PMID:34631566
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis. PMID:34630336
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4. PMID:34628485
Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells. PMID:34626204
Isoform-specific effects of transcription factor TCFL5 on the pluripotency-related genes SOX2 and KLF4 in colorectal cancer development. PMID:34623757
Predicting endometrial cancer subtypes and molecular features from histopathology images using multi-resolution deep learning models. PMID:34622237
LncRNA RNA Component of Mitochondrial RNA-Processing Endoribonuclease Promotes AKT-Dependent Breast Cancer Growth and Migration by Trapping MicroRNA-206. PMID:34621748
An Integrative Pan-Cancer Analysis of the Prognostic and Immunological Role of Casein Kinase 2 Alpha Protein 1 (CSNK2A1) in Human Cancers: A Study Based on Bioinformatics and Immunohistochemical Analysis. PMID:34621130
The role of ERBB4 mutations in the prognosis of advanced non-small cell lung cancer treated with immune checkpoint inhibitors. PMID:34620079
Molecular implications of HOX genes targeting multiple signaling pathways in cancer. PMID:34617205
Downregulated Expression of CLEC9A as Novel Biomarkers for Lung Adenocarcinoma. PMID:34616670
Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squamous NSCLC. PMID:34615542
Low expression of endoplasmic reticulum stress-related gene SERP1 is associated with poor prognosis and immune infiltration in skin cutaneous melanoma. PMID:34613934
Targeted Therapy for BRAF Mutant Brain Tumors. PMID:34613491
Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers. PMID:34611484
IER2-induced senescence drives melanoma invasion through osteopontin. PMID:34611309
Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway. PMID:34611298
Genomic characterization of rare molecular subclasses of hepatocellular carcinoma. PMID:34608257
Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors. PMID:34607897
Centrosome Aberrations as Drivers of Chromosomal Instability in Breast Cancer. PMID:34606589
Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review. PMID:34604242
Estrogen Receptor Is Expressed in Uveal Melanoma: A Potential Target for Therapy. PMID:34604204
Upregulation of ADAM12 Is Associated With a Poor Survival and Immune Cell Infiltration in Colon Adenocarcinoma. PMID:34604068
TNF-Alpha Pathway Alternation Predicts Survival of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer. PMID:34603277
Genetic evolution to tyrosine kinase inhibitory therapy in patients with EGFR-mutated non-small-cell lung cancer. PMID:34599295
The clinical behavior and genomic features of the so-called adenoid cystic carcinomas of the solid variant with basaloid features. PMID:34599282
Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer. PMID:34596356
UGT1A Gene Family Members Serve as Potential Targets and Prognostic Biomarkers for Pancreatic Cancer. PMID:34595239
Genomic evidence suggests that cutaneous neuroendocrine carcinomas can arise from squamous dysplastic precursors. PMID:34593967
BAP1 methylation: a prognostic marker of uveal melanoma metastasis. PMID:34593944
PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance. PMID:34593007
Using BioPAX-Parser (BiP) to enrich lists of genes or proteins with pathway data. PMID:34592927
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity. PMID:34591642
Interpretation of cancer mutations using a multiscale map of protein systems. PMID:34591613
Genomic and Transcriptomic Characterization of Relapsed SCLC Through Rapid Research Autopsy. PMID:34590014
Patients With BRAF-Mutant NSCLC May Not Benefit From Immune Checkpoint Inhibitors: A Population-Based Study. PMID:34589911
Pan-cancer analysis indicates that MYBL2 is associated with the prognosis and immunotherapy of multiple cancers as an oncogene. PMID:34585645
Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis. PMID:34585630
Obesity Promotes Tumor Immune Evasion in Ovarian Cancer Through Increased Production of Myeloid-Derived Suppressor Cells via IL-6. PMID:34584460
Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation. PMID:34584219
Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer. PMID:34583980
MLL3 is a de novo cause of endocrine therapy resistance. PMID:34581028
Cell Models for Chromosome 20q11.21 Amplification and Drug Sensitivities in Colorectal Cancer. PMID:34577783
Gene Dosage Analysis on the Single-Cell Transcriptomes Linking Cotranslational Protein Targeting to Metastatic Triple-Negative Breast Cancer. PMID:34577617
Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models. PMID:34576133
Analysis of SYK Gene as a Prognostic Biomarker and Suggested Potential Bioactive Phytochemicals as an Alternative Therapeutic Option for Colorectal Cancer: An In-Silico Pharmaco-Informatics Investigation. PMID:34575665
Expression and Clinical Utility of Transcription Factors Involved in Epithelial-Mesenchymal Transition during Thyroid Cancer Progression. PMID:34575184
Epigenetic Silencing of HER2 Expression during Epithelial-Mesenchymal Transition Leads to Trastuzumab Resistance in Breast Cancer. PMID:34575017
Genetic Variants and Somatic Alterations Associated with MITF-E318K Germline Mutation in Melanoma Patients. PMID:34573422
Identifying New Potential Biomarkers in Adrenocortical Tumors Based on mRNA Expression Data Using Machine Learning. PMID:34572898
Mutations in Epigenetic Regulation Genes in Gastric Cancer. PMID:34572812
The Role of p53 in Progression of Cutaneous Squamous Cell Carcinoma. PMID:34572732
Identifying GPSM Family Members as Potential Biomarkers in Breast Cancer: A Comprehensive Bioinformatics Analysis. PMID:34572330
A Preclinical Investigation of GBM-N019 as a Potential Inhibitor of Glioblastoma via Exosomal mTOR/CDK6/STAT3 Signaling. PMID:34572040
26S Proteasome Non-ATPase Regulatory Subunits 1 (PSMD1) and 3 (PSMD3) as Putative Targets for Cancer Prognosis and Therapy. PMID:34572038
Plectin in Cancer: From Biomarker to Therapeutic Target. PMID:34571895
DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. PMID:34568799
Metastatic Castration-Resistant Prostate Cancer Remains Dependent on Oncogenic Drivers Found in Primary Tumors. PMID:34568716
The Role of Akt in Acquired Cetuximab Resistant Head and Neck Squamous Cell Carcinoma: An In Vitro Study on a Novel Combination Strategy. PMID:34568028
Chromobox Homolog 8 (CBX8) in Human Tumor Carcinogenesis and Prognosis: A Pancancer Analysis Using Multiple Databases. PMID:34567093
Effect of MAP3K8 on Prognosis and Tumor-Related Inflammation in Renal Clear Cell Carcinoma. PMID:34567061
Identification of Novel Molecular Therapeutic Targets and Their Potential Prognostic Biomarkers Among Kinesin Superfamily of Proteins in Pancreatic Ductal Adenocarcinoma. PMID:34557409
The bioinformatics and experimental analysis of AlkB family for prognosis and immune cell infiltration in hepatocellular carcinoma. PMID:34557360
DZIP1 Expression as a Prognostic Marker in Gastric Cancer: A Bioinformatics-Based Analysis. PMID:34557018
Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner. PMID:34556788
Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer. PMID:34556703
Comparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer. PMID:34556657
Copy number alteration of the interferon gene cluster in cancer: Individual patient data meta-analysis prospects to personalized immunotherapy. PMID:34555656
RAF1 amplification drives a subset of bladder tumors and confers sensitivity to MAPK-directed therapeutics. PMID:34554931
Insulin and the insulin receptor collaborate to promote human gastric cancer. PMID:34554347
TBC1D3 family is a prognostic biomarker and correlates with immune infiltration in kidney renal clear cell carcinoma. PMID:34553038
Predicting chemotherapy response using a variational autoencoder approach. PMID:34551729
Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c-MYC. PMID:34551213
Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity. PMID:34550965
TERT Copy Number Alterations, Promoter Mutations and Rearrangements in Adrenocortical Carcinomas. PMID:34549366
Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents. PMID:34545188
Paired comparisons of mutational profiles before and after brachytherapy in asian uveal melanoma patients. PMID:34545149
The immunotherapy candidate TNFSF4 may help the induction of a promising immunological response in breast carcinomas. PMID:34545132
The Hippo pathway: an emerging role in urologic cancers. PMID:34541029
Comprehensive Analysis of HDAC Family Identifies HDAC1 as a Prognostic and Immune Infiltration Indicator and HDAC1-Related Signature for Prognosis in Glioma. PMID:34540896
Hallmarks of glycogene expression and glycosylation pathways in squamous and adenocarcinoma cervical cancer. PMID:34540372
A Comprehensive Multiomics Analysis Identified Ubiquilin 4 as a Promising Prognostic Biomarker of Immune-Related Therapy in Pan-Cancer. PMID:34539785
Multimetric feature selection for analyzing multicategory outcomes of colorectal cancer: random forest and multinomial logistic regression models. PMID:34537824
Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer. PMID:34535676
An IDO1-related immune gene signature predicts overall survival in acute myeloid leukemia. PMID:34535017
A newly established monoclonal antibody against ERCC1 detects major isoforms of ERCC1 in gastric cancer. PMID:34532603
Identification of solute-carrier family 27A molecules (SCL27As) as a potential biomarker of ovarian cancer based on bioinformatics and experiments. PMID:34532374
Comprehensive Analysis of E2F Family Members in Human Gastric Cancer. PMID:34532281
Identification of hub genes and functional modules in colon adenocarcinoma based on public databases by bioinformatics analysis. PMID:34532115
Comprehensive Analysis of the Expression and Prognosis for E2Fs in Human Clear Cell Renal Cell Carcinoma. PMID:34531966
TLR3 Serves as a Prognostic Biomarker and Associates with Immune Infiltration in the Renal Clear Cell Carcinoma Microenvironment. PMID:34531911
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures. PMID:34531868
SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia. PMID:34531253
The expression and potential mechanism of EGFR and EZH2 in breast cancer. PMID:34527565
The relationship between autophagy-related genes and the staging and prognosis of thyroid cancer: a bioinformatics analysis. PMID:34527563
A novel prognostic signature based on four glycolysis-related genes predicts survival and clinical risk of hepatocellular carcinoma. PMID:34523732
The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses. PMID:34522711
bFGF-mediated phosphorylation of δ-catenin increases its protein stability and the ability to induce the nuclear redistribution of β-catenin. PMID:34522455
Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter. PMID:34520744
The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis. PMID:34520390
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids. PMID:34518665
Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression. PMID:34518527
Targeting Tumor-Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer. PMID:34518296
Dissecting Tumor Antigens and Immune Subtypes of Glioma to Develop mRNA Vaccine. PMID:34512630
YTHDF2 is a Potential Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma. PMID:34512342
Pro-Oncogenic c-Met/EGFR, Biomarker Signatures of the Tumor Microenvironment are Clinical and Therapy Response Prognosticators in Colorectal Cancer, and Therapeutic Targets of 3-Phenyl-2H-benzo[e][1,3]-Oxazine-2,4(3H)-Dione Derivatives. PMID:34512327
Comprehensive Analysis of the Expression and Prognosis for Laminin Genes in Ovarian Cancer. PMID:34512203
Lysophosphatidic acid receptor 6 regulated by miR-27a-3p attenuates tumor proliferation in breast cancer. PMID:34510318
FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma. PMID:34510311
Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer. PMID:34509979
TARG1 protects against toxic DNA ADP-ribosylation. PMID:34508355
Comprehensive characterization of somatic variants associated with intronic polyadenylation in human cancers. PMID:34508351
DNA double-strand break repair in cancer: A path to achieving precision medicine. PMID:34507781
Exploring the Genomic Landscape of Cancer Patient Cohorts with GenVisR. PMID:34506690
Signet ring cell cancer of stomach and gastro-esophageal junction: molecular alterations, stage-stratified treatment approaches, and future challenges. PMID:34505199
Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases. PMID:34505004
The Cancer Epitope Database and Analysis Resource: A Blueprint for the Establishment of a New Bioinformatics Resource for Use by the Cancer Immunology Community. PMID:34504503
Differential whole-genome doubling and homologous recombination deficiencies across breast cancer subtypes from the Taiwanese population. PMID:34504292
Proteomics-derived basal biomarker DNA-PKcs is associated with intrinsic subtype and long-term clinical outcomes in breast cancer. PMID:34504086
Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity. PMID:34504076
CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data. PMID:34504064
Prognostic and Therapeutic Potential of the OIP5 Network in Papillary Renal Cell Carcinoma. PMID:34503297
Targeting CD82/KAI1 for Precision Therapeutics in Surmounting Metastatic Potential in Breast Cancer. PMID:34503296
Playing on the Dark Side: SMYD3 Acts as a Cancer Genome Keeper in Gastrointestinal Malignancies. PMID:34503239
TP53 in Biology and Treatment of Osteosarcoma. PMID:34503094
A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML. PMID:34502319
Unraveling the Relevance of ARL GTPases in Cutaneous Melanoma Prognosis through Integrated Bioinformatics Analysis. PMID:34502169
Zinc Favors Triple-Negative Breast Cancer's Microenvironment Modulation and Cell Plasticity. PMID:34502091
Canonical TGFβ Signaling and Its Contribution to Endometrial Cancer Development and Progression-Underestimated Target of Anticancer Strategies. PMID:34501347
Prognostic Biomarkers and Immunotherapeutic Targets Among CXC Chemokines in Pancreatic Adenocarcinoma. PMID:34497764
Evaluation of the Oncogene Function of GOLPH3 and Correlated Regulatory Network in Lung Adenocarcinoma. PMID:34497755
Comprehensive Analysis of YTH Domain Family in Lung Adenocarcinoma: Expression Profile, Association with Prognostic Value, and Immune Infiltration. PMID:34497675
A Novel Intercellular Communication-Associated Gene Signature for Prognostic Prediction and Clinical Value in Patients With Lung Adenocarcinoma. PMID:34497634
Stress-activated kinases as therapeutic targets in pancreatic cancer. PMID:34497429
CKS2 (CDC28 protein kinase regulatory subunit 2) is a prognostic biomarker in lower grade glioma: a study based on bioinformatic analysis and immunohistochemistry. PMID:34494924
Molecular profiling of advanced solid tumours. The impact of experimental molecular-matched therapies on cancer patient outcomes in early-phase trials: the MAST study. PMID:34493820
CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis. PMID:34493786
Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression. PMID:34493733
The genomic architecture of EBV and infected gastric tissue from precursor lesions to carcinoma. PMID:34493320
TIMELESS Promotes Tumor Progression by Enhancing Macrophages Recruitment in Ovarian Cancer. PMID:34490127
Prognostic role of EGR1 in breast cancer: a systematic review. PMID:34488929
The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy. PMID:34488905
Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis. PMID:34488675
Gene expression and prognosis of x-ray repair cross-complementing family members in non-small cell lung cancer. PMID:34486486
Prognostic value of TERF1 expression in prostate cancer. PMID:34486082
Transcriptomic Analyses Reveal B-Cell Translocation Gene 2 as a Potential Therapeutic Target in Ovarian Cancer. PMID:34485119
m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling. PMID:34484859
Nicardipine Inhibits Breast Cancer Migration via Nrf2/HO-1 Axis and Matrix Metalloproteinase-9 Regulation. PMID:34483918
Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma. PMID:34482803
Cancer testis antigens and genomic instability: More than immunology. PMID:34481156
Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer. PMID:34480250
SAMHD1 in cancer: curse or cure? PMID:34480199
Telomeric zinc-finger associated protein (TZAP) in cancer biology: friend or foe? PMID:34476265
Transcriptional expression of ZICs as an independent indicator of survival in gliomas. PMID:34475426
The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway. PMID:34471290
Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes. PMID:34470661
Virus-host interactions in carcinogenesis of Epstein-Barr virus-associated gastric carcinoma: Potential roles of lost ARID1A expression in its early stage. PMID:34469459
Integrative overview of IFITMs family based on Bioinformatics analysis. PMID:34466338
Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes. PMID:34465782
Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients. PMID:34461927
Mnt Represses Epithelial Identity To Promote Epithelial-to-Mesenchymal Transition. PMID:34460331
The Identification of the Metabolism Subtypes of Skin Cutaneous Melanoma Associated With the Tumor Microenvironment and the Immunotherapy. PMID:34458265
Overexpression of E74-like transformation-specific transcription factor 3 promotes cellular proliferation and predicts poor prognosis in ovarian cancer. PMID:34457065
Pan-cancer analysis of the oncogenic role of discs large homolog associated protein 5 (DLGAP5) in human tumors. PMID:34454476
Ruthenium Complexes: An Alternative to Platinum Drugs in Colorectal Cancer Treatment. PMID:34452256
Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer. PMID:34450249
Genomic Profiling of Prostate Cancer: An Updated Review. PMID:34448375
EGFR DNA Methylation Correlates With EGFR Expression, Immune Cell Infiltration, and Overall Survival in Lung Adenocarcinoma. PMID:34447695
Loss of ARID1A Promotes Hepatocellular Carcinoma Progression via Up-regulation of MYC Transcription. PMID:34447682
Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes. PMID:34446793
Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity. PMID:34446728
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer. PMID:34446716
METTL21B is a prognostic biomarker and potential therapeutic target in low-grade gliomas. PMID:34446611
MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin. PMID:34446068
Syndecan Family Gene and Protein Expression and Their Prognostic Values for Prostate Cancer. PMID:34445387
The SCF Complex Is Essential to Maintain Genome and Chromosome Stability. PMID:34445249
Multi-Omics Analysis of SOX4, SOX11, and SOX12 Expression and the Associated Pathways in Human Cancers. PMID:34442467
Association of TP53 Alteration with Tissue Specificity and Patient Outcome of IDH1-Mutant Glioma. PMID:34440884
Comprehensive Integrative Analysis Reveals the Association of KLF4 with Macrophage Infiltration and Polarization in Lung Cancer Microenvironment. PMID:34440860
Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer. PMID:34440533
Transcriptional Regulation of RUNX1: An Informatics Analysis. PMID:34440349
Post-Translational Modification of MRE11: Its Implication in DDR and Diseases. PMID:34440334
Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers. PMID:34440228
Predicting Agents That Can Overcome 5-FU Resistance in Colorectal Cancers via Pharmacogenomic Analysis. PMID:34440086
Investigation of Anti-Tumor Effects of an MLK1 Inhibitor in Prostate and Pancreatic Cancers. PMID:34439974
GNAi2/gip2-Regulated Transcriptome and Its Therapeutic Significance in Ovarian Cancer. PMID:34439877
Chromoanagenesis Landscape in 10,000 TCGA Patients. PMID:34439350
Pan-Cancer Analysis of Prognostic and Immune Infiltrates for CXCs. PMID:34439306
EVI2B Is a New Prognostic Biomarker in Metastatic Melanoma with IFNgamma Associated Immune Infiltration. PMID:34439264
Hypoxic Jumbo Spheroids On-A-Chip (HOnAChip): Insights into Treatment Efficacy. PMID:34439199
USP19 and RPL23 as Candidate Prognostic Markers for Advanced-Stage High-Grade Serous Ovarian Carcinoma. PMID:34439131
3q26 Amplifications in Cervical Squamous Carcinomas. PMID:34436017
Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma. PMID:34433873
How to Achieve Therapeutic Response in Erlotinib-Resistant Head and Neck Squamous Cell Carcinoma? New Insights from Stable Isotope Labeling with Amino Acids in Cell Culture-Based Quantitative Tyrosine Phosphoproteomics. PMID:34432535
Identification of GNA12-driven gene signatures and key signaling networks in ovarian cancer. PMID:34429759
Elevated mRNA Level of Y-Box Binding Protein 1 Indicates Unfavorable Prognosis Correlated with Macrophage Infiltration and T Cell Exhaustion in Luminal Breast Cancer. PMID:34429650
Mechanisms of targeted therapy resistance in a pediatric glioma driven by ETV6-NTRK3 fusion. PMID:34429303
SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia. PMID:34426610
IL6 and BCL3 Expression Are Potential Biomarkers in Esophageal Squamous Cell Carcinoma. PMID:34422669
Identification of Candidate Biomarkers and Prognostic Analysis in Colorectal Cancer Liver Metastases. PMID:34422629
DNA repair genes are associated with tumor tissue differentiation and immune environment in lung adenocarcinoma: a bioinformatics analysis based on big data. PMID:34422373
A phase II study of everolimus in patients with advanced solid malignancies with TSC1, TSC2, NF1, NF2 or STK11 mutations. PMID:34422335
Basic Pan-Cancer Analysis of the Carcinogenic Effects of Cyclin-Dependent Kinase 4 (CDK4) in Human Surface Tumors. PMID:34422248
A TIMM17A Regulatory Network Contributing to Breast Cancer. PMID:34421983
Two Similar Signatures for Predicting the Prognosis and Immunotherapy Efficacy of Stomach Adenocarcinoma Patients. PMID:34414187
DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma. PMID:34414037
The effects of T-DXd on the expression of HLA class I and chemokines CXCL9/10/11 in HER2-overexpressing gastric cancer cells. PMID:34413454
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology. PMID:34413304
ATR Inhibitor M6620 (VX-970) Enhances the Effect of Radiation in Non-Small Cell Lung Cancer Brain Metastasis Patient-Derived Xenografts. PMID:34413128
YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer. PMID:34408926
High Matrix Metalloproteinase 28 Expression is Associated with Poor Prognosis in Pancreatic Adenocarcinoma. PMID:34408436
Recurrent Human Papillomavirus-Related Head and Neck Cancer Undergoes Metabolic Reprogramming and Is Driven by Oxidative Phosphorylation. PMID:34407971
Induction of apically mistrafficked epiregulin disrupts epithelial polarity via aberrant EGFR signaling. PMID:34406412
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice. PMID:34406363
Disregulations of PURPL and MiR-338-3p Could Serve As Prognosis Biomarkers for Epithelial Ovarian Cancer. PMID:34405027
A Luminacin D Analog HL142 Inhibits Ovarian Tumor Growth and Metastasis by Reversing EMT and Attenuating the TGFβ and FAK Pathways. PMID:34405025
An immune cell infiltration-related gene signature predicts prognosis for bladder cancer. PMID:34404901
Clinical, genetic and pharmacological data support targeting the MEK5/ERK5 module in lung cancer. PMID:34404896
Bioinformatics analysis of the transcriptional expression of minichromosome maintenance proteins as potential indicators of survival in patients with cervical cancer. PMID:34404366
DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling. PMID:34399732
Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls. PMID:34398495
Potential Role of SWI/SNF Complex Subunit Actin-Like Protein 6A in Cervical Cancer. PMID:34395295
Comprehensive Analysis of the Expression and Prognosis Value of Chromobox Family Members in Clear Cell Renal Cell Carcinoma. PMID:34395271
MEK inhibition overcomes resistance to EphA2-targeted therapy in uterine cancer. PMID:34391578
Genomic landscape of a mouse model of diffuse-type gastric adenocarcinoma. PMID:34387762
Polyfunctional KLRG-1+CD57+ Senescent CD4+ T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients. PMID:34386013
Prognostic and Immunological Role of Gasdermin E in Pan-Cancer Analysis. PMID:34381728
Comprehensive Analysis of the Expression Characteristics of the Enhancer of the Zeste Homolog 2 Gene in Pan-Cancer. PMID:34381492
Regulatory T cells promote the stemness of leukemia stem cells through IL10 cytokine-related signaling pathway. PMID:34381181
Diffusion enables integration of heterogeneous data and user-driven learning in a desktop knowledge-base. PMID:34379637
SWI/SNF complex alterations as a biomarker of immunotherapy efficacy in pancreatic cancer. PMID:34375311
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. PMID:34373451
Molecular Pathology of Urothelial Carcinoma. PMID:34373092
Evidence for AJUBA-catenin-CDH4-linked differentiation resistance of mesenchymal stem cells implies tumorigenesis and progression of head and neck squamous cell carcinoma: a single-cell transcriptome approach. PMID:34368804
PSMB7 Is a Key Gene Involved in the Development of Multiple Myeloma and Resistance to Bortezomib. PMID:34367968
Multi-Omic Analyses of the m5C Regulator ALYREF Reveal Its Essential Roles in Hepatocellular Carcinoma. PMID:34367948
Identification and Validation of PIK3CA as a Marker Associated with Prognosis and Immune Infiltration in Renal Clear Cell Carcinoma. PMID:34367282
Polymorphous Low-Grade Neuroepithelial Tumor of the Young (PLNTY): Molecular Profiling Confirms Frequent MAPK Pathway Activation. PMID:34363682
Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction. PMID:34362880
NF1-Dependent Transcriptome Regulation in the Melanocyte Lineage and in Melanoma. PMID:34362135
Tumor Promoting Effect of BMP Signaling in Endometrial Cancer. PMID:34360647
Glutamatergic Signaling a Therapeutic Vulnerability in Melanoma. PMID:34359771
The Role of DND1 in Cancers. PMID:34359581
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. PMID:34358448
Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer. PMID:34356885
Molecular and Pathological Profiling of Corresponding Treatment-Naïve and Neoadjuvant Pazopanib-Treated High-Risk Soft Tissue Sarcoma Samples of the GISG-04/NOPASS Study. PMID:34356494
Genomic and transcriptomic alterations in m6A regulatory genes are associated with tumorigenesis and poor prognosis in head and neck squamous cell carcinoma. PMID:34354868
Immune cytolytic activity is associated with reduced intra-tumoral genetic heterogeneity and with better clinical outcomes in triple negative breast cancer. PMID:34354864
Analyzing Roles of NUSAP1 From Clinical, Molecular Mechanism and Immune Perspectives in Hepatocellular Carcinoma. PMID:34354737
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies. PMID:34352222
Pancreas cancer and BRCA: A critical subset of patients with improving therapeutic outcomes. PMID:34351646
Dual inhibition of FGFR4 and BCL-xL inhibits multi-resistant ovarian cancer with BCL2L1 gain. PMID:34351305
Adaptive immunity-related gene expression profile is correlated with clinical phenotype in patients with acute myeloid leukemia. PMID:34350254
Comprehensive analysis of the expression and prognosis for TNFAIPs in head and neck cancer. PMID:34344926
Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds. PMID:34344882
EHMT2 promotes the pathogenesis of hepatocellular carcinoma by epigenetically silencing APC expression. PMID:34344448
Sensitivity to targeted therapy differs between HER2-amplified breast cancer cells harboring kinase and helical domain mutations in PIK3CA. PMID:34344439
Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study. PMID:34343214
Revisiting vimentin: a negative surrogate marker of molecularly defined oligodendroglioma in adult type diffuse glioma. PMID:34338912
A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. PMID:34337560
Integrative Analysis of MUC4 to Prognosis and Immune Infiltration in Pan-Cancer: Friend or Foe? PMID:34336844
Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast Cancer. PMID:34336686
A Personalized Therapeutics Approach Using an In Silico Drosophila Patient Model Reveals Optimal Chemo- and Targeted Therapy Combinations for Colorectal Cancer. PMID:34336681
Identification and Validation of a Prognostic Signature for Prostate Cancer Based on Ferroptosis-Related Genes. PMID:34336641
Significant Diagnostic and Prognostic Value of FLAD1 and Related MicroRNAs in Breast Cancer after a Pan-Cancer Analysis. PMID:34336008
NMU Is a Poor Prognostic Biomarker in Patients with Lung Adenocarcinoma. PMID:34336003
Snail1 expression in endothelial cells controls growth, angiogenesis and differentiation of breast tumors. PMID:34335957
BZW2/5MP1 acts as a promising target in hepatocellular carcinoma. PMID:34335929
Integrative Bioinformatics Study of Tangeretin Potential Targets for Preventing Metastatic Breast Cancer. PMID:34335799
Comprehensive Analysis of the Value of SMYD Family Members in the Prognosis and Immune Infiltration of Malignant Digestive System Tumors. PMID:34335697
SIRT4 and SIRT6 Serve as Novel Prognostic Biomarkers With Competitive Functions in Serous Ovarian Cancer. PMID:34335684
Database mining analysis revealed the role of the putative H+/sugar transporter solute carrier family 45 in skin cutaneous melanoma. PMID:34334114
Nucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma. PMID:34334108
Expression and prognostic potential of PLEK2 in head and neck squamous cell carcinoma based on bioinformatics analysis. PMID:34331382
Genetic alterations and functional networks of m6A RNA methylation regulators in pancreatic cancer based on data mining. PMID:34330301
Ubiquitin-specific protease 15 contributes to gastric cancer progression by regulating the Wnt/β-catenin signaling pathway. PMID:34326621
High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer. PMID:34326474
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer. PMID:34326322
Activation of the ABCB1 Amplicon in Docetaxel- and Cabazitaxel-Resistant Prostate Cancer Cells. PMID:34326198
Pan-Cancer Prognostic Role and Targeting Potential of the Estrogen-Progesterone Axis. PMID:34322374
The repair gene BACH1 - a potential oncogene. PMID:34322202
Weighted Gene Co-expression Network Analysis Identified a Novel Thirteen-Gene Signature Associated With Progression, Prognosis, and Immune Microenvironment of Colon Adenocarcinoma Patients. PMID:34322151
Bioinformatics Analysis of KIF1A Expression and Gene Regulation Network in Ovarian Carcinoma. PMID:34321916
Analysis of therapeutic targets and prognostic biomarkers of CXC chemokines in cervical cancer microenvironment. PMID:34321012
Prognostic Role of Receptor Tyrosine Kinase-Like Orphan Receptors in Intestinal-Type Gastric Cancer. PMID:34319035
Pan-cancer analysis of non-coding recurrent mutations and their possible involvement in cancer pathogenesis. PMID:34316701
Role of ferroptosis-related genes in prognostic prediction and tumor immune microenvironment in colorectal carcinoma. PMID:34316400
Construction of a novel mRNA-signature prediction model for prognosis of bladder cancer based on a statistical analysis. PMID:34315402
The role of YTH domain containing 2 in epigenetic modification and immune infiltration of pan-cancer. PMID:34312987
RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer. PMID:34312180
MUSTARD-a comprehensive resource of mutation-specific therapies in cancer. PMID:34309639
Immune implication of FAM83D gene in hepatocellular carcinoma. PMID:34308751
Functional impact of cancer patient-associated Bcl-xL mutations. PMID:34308416
Genomic alterations and possible druggable mutations in carcinoma of unknown primary (CUP). PMID:34302033
AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B. PMID:34301793
Targeting EGFR Exon 20 Insertions in Non-Small Cell Lung Cancer: Recent Advances and Clinical Updates. PMID:34301786
Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1). PMID:34298996
Tetranucleotide and Low Microsatellite Instability Are Inversely Associated with the CpG Island Methylator Phenotype in Colorectal Cancer. PMID:34298744
Explainable Artificial Intelligence Reveals Novel Insight into Tumor Microenvironment Conditions Linked with Better Prognosis in Patients with Breast Cancer. PMID:34298668
Methyltransferases in the Pathogenesis of Keratinocyte Cancers. PMID:34298617
KiRNet: Kinase-centered network propagation of pharmacological screen results. PMID:34296206
NEK7 Promotes Pancreatic Cancer Progression And Its Expression Is Correlated With Poor Prognosis. PMID:34295827
Prognostic Values of E2F1/2 Transcriptional Expressions in Chromophobe Renal Cell Carcinoma Patients: Evidence from Bioinformatics Analysis. PMID:34295182
Comprehensive analysis of BTN3A1 in cancers: mining of omics data and validation in patient samples and cellular models. PMID:34293829
The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas. PMID:34293822
Identification of the m6A RNA Methylation Regulators WTAP as a Novel Prognostic Biomarker and Genomic Alterations in Cutaneous Melanoma. PMID:34291082
Gα15 in early onset of pancreatic ductal adenocarcinoma. PMID:34290274
Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer. PMID:34285249
Identification of prognostic long non-coding RNA signature with potential drugs in hepatocellular carcinoma. PMID:34285143
Single Cell Genetic Profiling of Tumors of Breast Cancer Patients Aged 50 Years and Older Reveals Enormous Intratumor Heterogeneity Independent of Individual Prognosis. PMID:34282768
Pursuit of Gene Fusions in Daily Practice: Evidence from Real-World Data in Wild-Type and Microsatellite Instable Patients. PMID:34282766
Adipocyte-driven unfolded protein response is a shared transcriptomic signature of metastatic prostate carcinoma cells. PMID:34280426
In silico model for miRNA-mediated regulatory network in cancer. PMID:34279571
Hepcidin Downregulation Correlates With Disease Aggressiveness And Immune Infiltration in Liver Cancers. PMID:34277457
PGK1 Is a Key Target for Anti-Glycolytic Therapy of Ovarian Cancer: Based on the Comprehensive Analysis of Glycolysis-Related Genes. PMID:34277429
Bioinformatics-Based Identification of Tumor Microenvironment-Related Prognostic Genes in Pancreatic Cancer. PMID:34276760
Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort. PMID:34276383
The Progenetix oncogenomic resource in 2021. PMID:34272855
Correlation between targeted RNAseq signature of breast cancer CTCs and onset of bone-only metastases. PMID:34272498
Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma. PMID:34272452
Tumor microenvironment-adjusted prognostic implications of the KRAS mutation subtype in patients with stage III colorectal cancer treated with adjuvant FOLFOX. PMID:34272423
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. PMID:34270926
Analysis of the Prognostic Value and Gene Expression Mechanism of SHOX2 in Lung Adenocarcinoma. PMID:34262939
Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortia. PMID:34262154
Integrated digital pathology at scale: A solution for clinical diagnostics and cancer research at a large academic medical center. PMID:34260720
Accelerating precision medicine in metastatic prostate cancer. PMID:34258585
Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection. PMID:34257580
Notch1 Deficiency Induces Tumor Cell Accumulation Inside the Bronchiolar Lumen and Increases TAZ Expression in an Autochthonous Kras LSL-G12V Driven Lung Cancer Mouse Model. PMID:34257546
Expression, Prognosis and Gene Regulation Network of NFAT Transcription Factors in Non-Small Cell Lung Cancer. PMID:34257525
Solute carrier transporter superfamily member SLC16A1 is a potential prognostic biomarker and associated with immune infiltration in skin cutaneous melanoma. PMID:34254872
Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response. PMID:34253873
A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases. PMID:34253785
OncoThreads: visualization of large-scale longitudinal cancer molecular data. PMID:34252935
Methylation silencing CDH23 is a poor prognostic marker in diffuse large B-cell lymphoma. PMID:34252883
Data mining-based study of collagen type III alpha 1 (COL3A1) prognostic value and immune exploration in pan-cancer. PMID:34252356
Exceptional Response to Trastuzumab in a Heavily Pretreated Patient With ERBB3-Mutated Metastatic Breast Cancer. PMID:34250408
Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer. PMID:34250404
Identification of Targetable Gene Fusions and Structural Rearrangements to Foster Precision Medicine in KRAS Wild-Type Pancreatic Cancer. PMID:34250383
Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer. PMID:34249755
ASRGL1 Correlates With Immune Cell Infiltration in Hepatocellular Carcinoma and Can Serve as a Prognostic Biomarker. PMID:34249720
TFPI2 Promotes Perivascular Migration in an Angiotropism Model of Melanoma. PMID:34249699
G2M checkpoint pathway alone is associated with drug response and survival among cell proliferation-related pathways in pancreatic cancer. PMID:34249445
Identification of an EMT-Related Gene Signature for Predicting Overall Survival in Gastric Cancer. PMID:34249086
Association of CLDN6 and CLDN10 With Immune Microenvironment in Ovarian Cancer: A Study of the Claudin Family. PMID:34249076
Pan-Cancer Analysis Identifies Liver Metastases as Negative Predictive Factor for Immune Checkpoint Inhibitors Treatment Outcome. PMID:34248939
Bioinformatics analysis of the role of CXC ligands in the microenvironment of head and neck tumor. PMID:34247149
A positive feedback regulatory loop involving the lncRNA PVT1 and HIF-1α in pancreatic cancer. PMID:34245303
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine. PMID:34244484
Role of chromosome 1q copy number variation in hepatocellular carcinoma. PMID:34239701
Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells. PMID:34239121
Thioredoxin reductase is a major regulator of metabolism in leukemia cells. PMID:34239044
Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression. PMID:34237057
Sphingosine-1-Phosphate Catabolizing Enzymes Predict Better Prognosis in Triple-Negative Breast Cancer Patients and Correlates With Tumor-Infiltrating Immune Cells. PMID:34235182
Molecular Associations and Clinical Significance of RAPs in Hepatocellular Carcinoma. PMID:34235179
A miR-212-3p/SLC6A1 Regulatory Sub-Network for the Prognosis of Hepatocellular Carcinoma. PMID:34234551
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma. PMID:34231338
miR-133b targets NCAPH to promote β-catenin degradation and reduce cancer stem cell maintenance in non-small cell lung cancer. PMID:34230450
Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication. PMID:34228709
Prognostic and immunological value of ATP6AP1 in breast cancer: implications for SARS-CoV-2. PMID:34228637
Abnormal expression and methylation of PRR34-AS1 are associated with adverse outcomes in acute myeloid leukemia. PMID:34227248
Multi-omics landscape of circadian rhythm pathway alterations in Glioma. PMID:34224318
CBX4 Provides an Alternate Mode of Colon Cancer Development via Potential Influences on Circadian Rhythm and Immune Infiltration. PMID:34222240
The pattern of gene copy number alteration (CNAs) in hepatocellular carcinoma: an in silico analysis. PMID:34215297
Differential gene expression identifies a transcriptional regulatory network involving ER-alpha and PITX1 in invasive epithelial ovarian cancer. PMID:34215221
eVIP2: Expression-based variant impact phenotyping to predict the function of gene variants. PMID:34214079
Exploiting epigenetic dependencies in ovarian cancer therapy. PMID:34213777
CD38 Multi-Functionality in Oral Squamous Cell Carcinoma: Prognostic Implications, Immune Balance, and Immune Checkpoint. PMID:34211854
A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated prostate cancer. PMID:34211036
High-resolution characterization of gene function using single-cell CRISPR tiling screen. PMID:34210975
CACNA1C is a prognostic predictor for patients with ovarian cancer. PMID:34210324
Abnormal Long Non-Coding RNAs Expression Patterns Have the Potential Ability for Predicting Survival and Treatment Response in Breast Cancer. PMID:34209776
Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer. PMID:34209750
Integrative cBioPortal Analysis Revealed Molecular Mechanisms That Regulate EGFR-PI3K-AKT-mTOR Pathway in Diffuse Gliomas of the Brain. PMID:34209611
Evaluation of Darolutamide (ODM201) Efficiency on Androgen Receptor Mutants Reported to Date in Prostate Cancer Patients. PMID:34208290
Higher Integrin Alpha 3 Beta1 Expression in Papillary Thyroid Cancer Is Associated with Worst Outcome. PMID:34208249
Clinicopathological Significance of Syndecan-1 in Cholangiocarcinoma: A Study Based on Immunohistochemistry and Public Sequencing Data. PMID:34206469
Histone H2B Mutations in Cancer. PMID:34205231
Comprehensive Analysis of SFRP Family Members Prognostic Value and Immune Infiltration in Gastric Cancer. PMID:34205081
Evaluation of Somatic Mutations in Solid Metastatic Pan-Cancer Patients. PMID:34204917
Molecular Characterization of Muellerian Tumors of the Urinary Tract. PMID:34200508
Biphasic α2β1 Integrin Expression in Breast Cancer Metastasis to Bone. PMID:34199096
miRNA Clusters with Up-Regulated Expression in Colorectal Cancer. PMID:34198662
WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-κB activation. PMID:34197030
Comprehensive analysis of cytoskeleton regulatory genes identifies ezrin as a prognostic marker and molecular target in acute myeloid leukemia. PMID:34196912
Analyzing the influence of IL18 in regulation of YAP1 in breast oncogenesis using cBioportal. PMID:34196131
Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma. PMID:34193180
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. PMID:34192534
Comprehensive Analysis of Prognostic Value of MEX3A and Its Relationship with Immune Infiltrates in Ovarian Cancer. PMID:34189143
CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP. PMID:34187934
Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo. PMID:34187574
Functions and clinical significance of KLRG1 in the development of lung adenocarcinoma and immunotherapy. PMID:34187403
m6A RNA methylation regulators were associated with the malignancy and prognosis of ovarian cancer. PMID:34187307
Identification of Endogenous Kinase Substrates by Proximity Labeling Combined with Kinase Perturbation and Phosphorylation Motifs. PMID:34186244
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation. PMID:34186021
HAI-1 is an independent predictor of lung cancer mortality and is required for M1 macrophage polarization. PMID:34185790
HSD17B7 gene in self-renewal and oncogenicity of keratinocytes from Black versus White populations. PMID:34185380
CRY2 missense mutations suppress P53 and enhance cell growth. PMID:34183418
Quantum processor-inspired machine learning in the biomedical sciences. PMID:34179840
Prevalence and Spectrum of Germline BRCA1 and BRCA2 Variants of Uncertain Significance in Breast/Ovarian Cancer: Mysterious Signals From the Genome. PMID:34178674
LpCat1 Promotes Malignant Transformation of Hepatocellular Carcinoma Cells by Directly Suppressing STAT1. PMID:34178664
Integrative Multi-Omics Analysis of Identified NUF2 as a Candidate Oncogene Correlates With Poor Prognosis and Immune Infiltration in Non-Small Cell Lung Cancer. PMID:34178642
The Gain-of-Function p53 R248W Mutant Promotes Migration by STAT3 Deregulation in Human Pancreatic Cancer Cells. PMID:34178628
p38β - MAPK11 and its role in female cancers. PMID:34174910
LABRAT reveals association of alternative polyadenylation with transcript localization, RNA binding protein expression, transcription speed, and cancer survival. PMID:34174817
SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma. PMID:34173014
A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma. PMID:34172930
The clinical and molecular significance associated with STING signaling in breast cancer. PMID:34172750
Regulation of CD47 expression by interferon-gamma in cancer cells. PMID:34171557
miR-181b-5p Promotes the Progression of Cholangiocarcinoma by Targeting PARK2 via PTEN/PI3K/AKT Signaling Pathway. PMID:34169384
SLC15A4 Serves as a Novel Prognostic Biomarker and Target for Lung Adenocarcinoma. PMID:34168674
Molecular alterations in basal cell carcinoma subtypes. PMID:34168209
RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer. PMID:34168046
SLC7A5 serves as a prognostic factor of breast cancer and promotes cell proliferation through activating AKT/mTORC1 signaling pathway. PMID:34164526
Earlier extracranial progression and shorter survival in ALK-rearranged lung cancer with positive liquid rebiopsies. PMID:34164264
Zc3h12d, a Novel of Hypomethylated and Immune-Related for Prognostic Marker of Lung Adenocarcinoma. PMID:34163207
Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia. PMID:34162911
Insights of fibroblast growth factor receptor 3 aberrations in pan-cancer and their roles in potential clinical treatment. PMID:34160364
Long-term disease control and survival observed after stereotactic ablative body radiotherapy for oligometastatic breast cancer. PMID:34159748
TPM, FPKM, or Normalized Counts? A Comparative Study of Quantification Measures for the Analysis of RNA-seq Data from the NCI Patient-Derived Models Repository. PMID:34158060
Identification of Somatic Gene Signatures in Circulating Cell-Free DNA Associated with Disease Progression in Metastatic Prostate Cancer by a Novel Machine Learning Platform. PMID:34157173
CALM supports clathrin-coated vesicle completion upon membrane tension increase. PMID:34155137
TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma. PMID:34148105
Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. PMID:34145784
Fatty Acid Synthesis in Prostate Cancer: Vulnerability or Epiphenomenon? PMID:34145040
E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer. PMID:34143182
Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation. PMID:34142658
Construction of a Myc-associated ceRNA network reveals a prognostic signature in hepatocellular carcinoma. PMID:34141458
DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma. PMID:34140574
Erlotinib and Onalespib Lactate Focused on EGFR Exon 20 Insertion Non-Small Cell Lung Cancer (NSCLC): A California Cancer Consortium Phase I/II Trial (NCI 9878). PMID:34140248
Whole-Exome Sequencing Analysis of Oral Squamous Cell Carcinoma Delineated by Tobacco Usage Habits. PMID:34136393
Mutant p53s and chromosome 19 microRNA cluster overexpression regulate cancer testis antigen expression and cellular transformation in hepatocellular carcinoma. PMID:34135394
Pan-cancer analysis reveals an immunological role and prognostic potential of PXN in human cancer. PMID:34135128
Telomere Attrition and p53 Response 1 (TAPR1): a new player in cancer biology? PMID:34133663
The role of RB1 alteration and 4q12 amplification in IDH-WT glioblastoma. PMID:34131647
Absent in melanoma 1-like (AIM1L) serves as a novel candidate for overall survival in hepatocellular carcinoma. PMID:34130591
Molecular classification and diagnostics of upper urinary tract urothelial carcinoma. PMID:34129823
Identification of a prognostic metabolic gene signature in diffuse large B-cell lymphoma. PMID:34128320
Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy. PMID:34127768
Rewiring of Lactate-Interleukin-1β Autoregulatory Loop with Clock-Bmal1: a Feed-Forward Circuit in Glioma. PMID:34124933
Establishment of Novel Prostate Cancer Risk Subtypes and A Twelve-Gene Prognostic Model. PMID:34124157
IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment. PMID:34123844
Bioinformatics, Molecular Docking and Experiments In Vitro Analyze the Prognostic Value of CXC Chemokines in Breast Cancer. PMID:34123826
Highly connected, non-redundant microRNA functional control in breast cancer molecular subtypes. PMID:34123357
METTL14 Acts as a Potential Regulator of Tumor Immune and Progression in Clear Cell Renal Cell Carcinoma. PMID:34122497
PSMA radioligand therapy for solid tumors other than prostate cancer: background, opportunities, challenges, and first clinical reports. PMID:34120192
The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer. PMID:34118960
Prognostic value of tumor mutational burden in patients with oral cavity squamous cell carcinoma treated with upfront surgery. PMID:34118772
Oncogene-regulated release of extracellular vesicles. PMID:34118203
Identification of a Novel Inflamed Tumor Microenvironment Signature as a Predictive Biomarker of Bacillus Calmette-Guérin Immunotherapy in Non-Muscle-Invasive Bladder Cancer. PMID:34117034
Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation. PMID:34116687
Human Gastric Cancer Stem Cell (GCSC) Markers Are Prognostic Factors Correlated With Immune Infiltration of Gastric Cancer. PMID:34113647
A Bioinformatics Analysis of the Potential Roles of Aquaporin 4 in Human Brain Tumors: An Immune-Related Process. PMID:34113257
Protein citrullination as a source of cancer neoantigens. PMID:34112737
Expression pattern and prognostic impact of glycoprotein non-metastatic B (GPNMB) in triple-negative breast cancer. PMID:34108545
Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer. PMID:34108519
Heterogeneity in NECTIN4 Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin. PMID:34108177
Anti-PD-1 elicits regression of undifferentiated pleomorphic sarcomas with UV-mutation signatures. PMID:34103354
STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR/MAPK signaling pathway. PMID:34102455
Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer. PMID:34100918
Alterations in the RTK/Ras/PI3K/AKT pathway serve as potential biomarkers for immunotherapy outcome of diffuse gliomas. PMID:34100771
ALDH1 expression predicts progression of premalignant lesions to cancer in Type I endometrial carcinomas. PMID:34099751
Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer. PMID:34099734
Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma. PMID:34097975
Integrating Somatic and Germline Next-Generation Sequencing Into Routine Clinical Oncology Practice. PMID:34095711
Low Expression of RILPL2 Predicts Poor Prognosis and Correlates With Immune Infiltration in Endometrial Carcinoma. PMID:34095226
ADORA1 is a diagnostic-related biomarker and correlated with immune infiltrates in papillary thyroid carcinoma. PMID:34093805
Glyoxalase 1 and protein kinase Cλ as potential therapeutic targets for late-stage breast cancer. PMID:34093768
Elevated Expression of PDZD11 Is Associated With Poor Prognosis and Immune Infiltrates in Hepatocellular Carcinoma. PMID:34093661
PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma. PMID:34093649
E2F2 inhibition induces autophagy via the PI3K/Akt/mTOR pathway in gastric cancer. PMID:34091441
Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM). PMID:34088988
CXCL2/10/12/14 are prognostic biomarkers and correlated with immune infiltration in hepatocellular carcinoma. PMID:34085699
Multidimensional study of cell division cycle-associated proteins with prognostic value in gastric carcinoma. PMID:34082692
MLN4924 inhibits cell proliferation by targeting the activated neddylation pathway in endometrial carcinoma. PMID:34082605
Identification and assessment of PLK1/2/3/4 in lung adenocarcinoma and lung squamous cell carcinoma: Evidence from methylation profile. PMID:34080290
MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF. PMID:34079078
Histologic and genomic features of breast cancers with alterations affecting the SWI/SNF (SMARC) genes. PMID:34079072
Identification of gastric cancer subtypes based on pathway clustering. PMID:34079012
Expression profiles and prognostic values of BolA family members in ovarian cancer. PMID:34078439
The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51. PMID:34077419
ENTPD5: identification of splicing variants and their impact on cancer survival. PMID:34075526
A mosaic PIK3CA variant in a young adult with diffuse gastric cancer: case report. PMID:34075207
Pan-cancer analysis of the prognostic value of C12orf75 based on data mining. PMID:34074799
In-Silico Evaluation of Genetic Alterations in Ovarian Carcinoma and Therapeutic Efficacy of NSC777201, as a Novel Multi-Target Agent for TTK, NEK2, and CDK1. PMID:34072728
PERK/ATF4-Dependent ZFAS1 Upregulation Is Associated with Sorafenib Resistance in Hepatocellular Carcinoma Cells. PMID:34072570
LncRNA PART1 Promotes Proliferation and Migration, Is Associated with Cancer Stem Cells, and Alters the miRNA Landscape in Triple-Negative Breast Cancer. PMID:34072264
Altered Expression of Secreted Mediator Genes That Mediate Aggressive Breast Cancer Metastasis to Distant Organs. PMID:34072157
Higher EU-TIRADS-Score Correlated with BRAF V600E Positivity in the Early Stage of Papillary Thyroid Carcinoma. PMID:34070605
Survival-Critical Genes Associated with Copy Number Alterations in Lung Adenocarcinoma. PMID:34070461
Prognostic Role of Immune Checkpoint Regulators in Cholangiocarcinoma: A Pilot Study. PMID:34069452
The ATM Gene in Breast Cancer: Its Relevance in Clinical Practice. PMID:34068084
Molecular Mechanisms of PD-1 and PD-L1 Activity on a Pan-Cancer Basis: A Bioinformatic Exploratory Study. PMID:34067485
Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity. PMID:34067020
Cell-Free DNA Analysis by Whole-Exome Sequencing for Hepatocellular Carcinoma: A Pilot Study in Thailand. PMID:34066484
LIMK2-NKX3.1 Engagement Promotes Castration-Resistant Prostate Cancer. PMID:34066036
Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics. PMID:34065652
BMAL1 Knockdown Leans Epithelial-Mesenchymal Balance toward Epithelial Properties and Decreases the Chemoresistance of Colon Carcinoma Cells. PMID:34065633
Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells-Relevance for Understanding (Germ Cell) Tumorigenesis. PMID:34065345
Prognostic Significance of BIRC5/Survivin in Breast Cancer: Results from Three Independent Cohorts. PMID:34064473
RLIP76: A Structural and Functional Triumvirate. PMID:34064388
High glucose induced c-Met activation promotes aggressive phenotype and regulates expression of glucose metabolism genes in HCC cells. PMID:34059694
The expression profiles and prognostic values of HSP70s in hepatocellular carcinoma. PMID:34059060
SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA-deficient cells. PMID:34058059
Deep Genomic Sequencing of Bladder Urothelial Carcinoma in Southern Chinese Patients: A Single-Center Study. PMID:34055593
Clinicopathological Significance of FOXO4 Expression and Correlation with Prx1 in Head and Neck Squamous Cell Carcinoma. PMID:34055579
Utilizing Publicly Available Cancer Clinicogenomic Data on CBioPortal to Compare Epidermal Growth Factor Receptor Mutant and Wildtype Non-Small Cell Lung Cancer. PMID:34055528
A case series of extraneural metastatic glioblastoma at Memorial Sloan Kettering Cancer Center. PMID:34055380
OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis. PMID:34050636
A multiple network-based bioinformatics pipeline for the study of molecular mechanisms in oncological diseases for personalized medicine. PMID:34050359
dbGENVOC: database of GENomic Variants of Oral Cancer, with special reference to India. PMID:34048545
Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer. PMID:34047812
Recurrent Somatic MAP2K1 Mutations in Papillary Thyroid Cancer and Colorectal Cancer. PMID:34046359
Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma. PMID:34045512
MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer. PMID:34045467
The effects of ARID1A mutations on colorectal cancer and associations with PD-L1 expression by stromal cells. PMID:34042312
Identification of prognostic and bone metastasis-related alternative splicing signatures in mesothelioma. PMID:34041868
The relationship between PLOD1 expression level and glioma prognosis investigated using public databases. PMID:34040895
Somatic PIK3R1 variation as a cause of vascular malformations and overgrowth. PMID:34040190
High Response Rate and Durability Driven by HLA Genetic Diversity in Patients with Kidney Cancer Treated with Lenvatinib and Pembrolizumab. PMID:34039647
NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development. PMID:34037780
Increased expression of KPNA2 predicts unfavorable prognosis in ovarian cancer patients, possibly by targeting KIF4A signaling. PMID:34034774
Transcription Factor-Binding Site Identification and Enrichment Analysis. PMID:34033108
KIF4A as a novel prognostic biomarker in cholangiocarcinoma. PMID:34032761
Mammary epithelial cells have lineage-rooted metabolic identities. PMID:34031589
In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy. PMID:34031411
Identification of combinations of somatic mutations that predict cancer survival and immunotherapy benefit. PMID:34027407
MLH1 Deficiency Down-Regulates TLR4 Expression in Sporadic Colorectal Cancer. PMID:34026821
Integrated Analysis of Nine Prognostic RNA-Binding Proteins in Soft Tissue Sarcoma. PMID:34026613
YTHDF1 Is a Potential Pan-Cancer Biomarker for Prognosis and Immunotherapy. PMID:34026603
Identification of potential diagnostic and prognostic biomarkers for LUAD based on TCGA and GEO databases. PMID:34017995
Mutational signatures impact the evolution of anti-EGFR antibody resistance in colorectal cancer. PMID:34017094
Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer. PMID:34016083
Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma. PMID:34015961
Obscurin: A multitasking giant in the fight against cancer. PMID:34015411
The Role of Neurodevelopmental Pathways in Brain Tumors. PMID:34012965
Comprehensive analysis of the prognostic value of the chemokine-like factor-like MARVEL transmembrane domain-containing family in gastric cancer. PMID:34012634
Expression and prognostic significance of thrombospondin gene family in gastric cancer. PMID:34012631
Adaptive immunity profiling associated with histological subtypes and postoperative survival in gastric cancer. PMID:34012629
Lymphoproliferative malignancies in patients with neurofibromatosis 1. PMID:34011343
Copy number aberrations drive kinase rewiring, leading to genetic vulnerabilities in cancer. PMID:34010657
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer. PMID:34004147
Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure. PMID:34003820
Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1. PMID:34003553
uPA-PAI-1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils. PMID:33998175
SynLeGG: analysis and visualization of multiomics data for discovery of cancer 'Achilles Heels' and gene function relationships. PMID:33997893
Diagnostic, Therapeutic, and Prognostic Value of the Thrombospondin Family in Gastric Cancer. PMID:33996903
Chaperonin-Containing TCP1 Complex (CCT) Promotes Breast Cancer Growth Through Correlations With Key Cell Cycle Regulators. PMID:33996588
MTFR2, A Potential Biomarker for Prognosis and Immune Infiltrates, Promotes Progression of Gastric Cancer Based on Bioinformatics Analysis and Experiments. PMID:33995638
Extracellular Vesicles: A Novel Tool Facilitating Personalized Medicine and Pharmacogenomics in Oncology. PMID:33995103
Chromosome 20q11.21 Amplifications in Colorectal Cancer. PMID:33994370
GNAQ knockdown promotes bone metastasis through epithelial-mesenchymal transition in lung cancer cells. PMID:33993733
Enabling Precision Medicine in Cancer Care Through a Molecular Data Warehouse: The Moffitt Experience. PMID:33989014
Zebrafish Cancer Predisposition Models. PMID:33987182
Identification and Validation of SNP-Containing Genes With Prognostic Value in Gastric Cancer via Integrated Bioinformatics Analysis. PMID:33987081
Capturing dynamic relevance in Boolean networks using graph theoretical measures. PMID:33983406
Role of Chromodomain-Helicase-DNA-Binding Protein 4 (CHD4) in Breast Cancer. PMID:33981601
Glycolysis-Based Genes Are Potential Biomarkers in Thyroid Cancer. PMID:33981593
FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036. PMID:33980863
BRAFnon-V600E more frequently co-occurs with IDH1/2 mutations in adult patients with gliomas than in patients harboring BRAFV600E but without a survival advantage. PMID:33980169
Expression Pattern and Prognostic Value of EPHA/EFNA in Breast Cancer by Bioinformatics Analysis: Revealing Its Importance in Chemotherapy. PMID:33977106
Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy. PMID:33976322
Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly. PMID:33976187
Limited inhibition of multiple nodes in a driver network blocks metastasis. PMID:33973518
Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence. PMID:33972599
Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas. PMID:33972520
Discovery of Candidate DNA Methylation Cancer Driver Genes. PMID:33972312
Validation of the functions and prognostic values of synapse-associated proteins in lower-grade glioma. PMID:33969375
A Novel Role for Brain and Acute Leukemia Cytoplasmic (BAALC) in Human Breast Cancer Metastasis. PMID:33968759
A Pancancer Analysis of the Expression Landscape and Clinical Relevance of Fibroblast Growth Factor Receptor 2 in Human Cancers. PMID:33968743
Neutrophil Elastase Defects in Congenital Neutropenia. PMID:33968054
RFX1: a promising therapeutic arsenal against cancer. PMID:33964962
Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461. PMID:33963218
Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period. PMID:33963205
Intrahepatic Cholangiocarcinoma with Lymph Node Metastasis: Treatment-Related Outcomes and the Role of Tumor Genomics in Patient Selection. PMID:33963001
EARN: an ensemble machine learning algorithm to predict driver genes in metastatic breast cancer. PMID:33962648
Analysis of the EGFR Amplification and CDKN2A Deletion Regulated Transcriptomic Signatures Reveals the Prognostic Significance of SPATS2L in Patients With Glioma. PMID:33959491
Developing Precision Medicine for Bladder Cancer. PMID:33958155
Systematic interrogation of mutation groupings reveals divergent downstream expression programs within key cancer genes. PMID:33957863
Predictive Value of KDM5C Alterations for Immune Checkpoint Inhibitors Treatment Outcomes in Patients With Cancer. PMID:33953726
Bioinformatic analyses and experimental validation of the role of m6A RNA methylation regulators in progression and prognosis of adrenocortical carcinoma. PMID:33952721
Prognostic and immunological potential of PPM1G in hepatocellular carcinoma. PMID:33952716
Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer. PMID:33952262
Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes. PMID:33947695
Genomic Characterization of Concurrent Alterations in Non-Small Cell Lung Cancer (NSCLC) Harboring Actionable Mutations. PMID:33946519
Targeting epigenetic mechanisms to overcome venetoclax resistance. PMID:33945824
The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling. PMID:33941855
Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy. PMID:33941852
Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer. PMID:33937026
Advances of Fibroblast Growth Factor/Receptor Signaling Pathway in Hepatocellular Carcinoma and its Pharmacotherapeutic Targets. PMID:33935756
Comprehensive analysis of prognostic value and immune infiltration of kindlin family members in non-small cell lung cancer. PMID:33934696
Establishment of a prognostic model of four genes in gastric cancer based on multiple data sets. PMID:33934516
Prostate cancer patient-derived organoids: detailed outcome from a prospective cohort of 81 clinical specimens. PMID:33934365
Targeting the PI3K and MAPK pathways to improve response to HER2-targeted therapies in HER2-positive gastric cancer. PMID:33933113
Identification of inhibitory immune checkpoints and relevant regulatory pathways in breast cancer stem cells. PMID:33932112
Mutant KRAS Downregulates the Receptor for Leukemia Inhibitory Factor (LIF) to Enhance a Signature of Glycolysis in Pancreatic Cancer and Lung Cancer. PMID:33931487
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer. PMID:33931024
Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort. PMID:33927264
Ten-eleven translocation protein 1 modulates medulloblastoma progression. PMID:33926529
Identification of a ferroptosis-related gene signature predictive model in colon cancer. PMID:33926457
Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex. PMID:33925740
Genomic Correlates of DNA Damage in Breast Cancer Subtypes. PMID:33925616
ING Proteins: Tumour Suppressors or Oncoproteins. PMID:33925563
Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches. PMID:33925358
The Role of Wild-Type RAS in Oncogenic RAS Transformation. PMID:33924994
The ECM Modulator ITIH5 Affects Cell Adhesion, Motility and Chemotherapeutic Response of Basal/Squamous-Like (BASQ) Bladder Cancer Cells. PMID:33924987
The Role of p53 Signaling in Colorectal Cancer. PMID:33924934
Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. PMID:33922599
A Bioinformatics Analysis Identifies the Telomerase Inhibitor MST-312 for Treating High-STMN1-Expressing Hepatocellular Carcinoma. PMID:33922244
Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer. PMID:33921749
MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model. PMID:33921698
The Expression Regulation and Biological Function of Autotaxin. PMID:33921676
Melanoma Associated Chitinase 3-Like 1 Promoted Endothelial Cell Activation and Immune Cell Recruitment. PMID:33920100
Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses. PMID:33918976
Neuropilin-2 and Its Transcript Variants Correlate with Clinical Outcome in Bladder Cancer. PMID:33918816
Loss of the Metastasis Suppressor NME1, But Not of Its Highly Related Isoform NME2, Induces a Hybrid Epithelial-Mesenchymal State in Cancer Cells. PMID:33918324
CK2 Activity Mediates the Aggressive Molecular Signature of Glioblastoma Multiforme by Inducing Nerve/Glial Antigen (NG)2 Expression. PMID:33918235
The rs599839 A>G Variant Disentangles Cardiovascular Risk and Hepatocellular Carcinoma in NAFLD Patients. PMID:33917919
Tumor Signature Analysis Implicates Hereditary Cancer Genes in Endometrial Cancer Development. PMID:33917078
Targeting Protein Kinase C in Glioblastoma Treatment. PMID:33916593
Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation. PMID:33916378
Identification of Expression Patterns and Potential Prognostic Significance of m5C-Related Regulators in Head and Neck Squamous Cell Carcinoma. PMID:33912441
A New Insight for the Identification of Oncogenic Variants in Breast and Prostate Cancers in Diverse Human Populations, With a Focus on Latinos. PMID:33912047
Providing an optimized model to detect driver genes from heterogeneous cancer samples using restriction in subspace learning. PMID:33911156
Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities. PMID:33910596
Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action. PMID:33909629
Diffuse midline glioma with H3 K27M-mutation in an 83-year-old woman. PMID:33908265
ARHGAP20 Expression Inhibited HCC Progression by Regulating the PI3K-AKT Signaling Pathway. PMID:33907697
The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells. PMID:33907253
Interferon regulatory factor transcript levels correlate with clinical outcomes in human glioma. PMID:33902005
Systemic analysis of the expression levels and prognosis of breast cancer-related cadherins. PMID:33899544
Study on the Prognostic Values of Dynactin Genes in Low-Grade Glioma. PMID:33896271
Update on genomic and molecular landscapes of well-differentiated liposarcoma and dedifferentiated liposarcoma. PMID:33893924
The expression and prognostic value of the epidermal growth factor receptor family in glioma. PMID:33892666
HER2 transmembrane domain mutation: comprehensive characteristics and real-world evidence of treatment response in Chinese lung adenocarcinoma. PMID:33889517
Predicting clinical outcomes using cancer progression associated signatures. PMID:33889305
Up to your NEK2 in CIN. PMID:33889296
Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens. PMID:33888849
Surface Expression of Kynurenine 3-Monooxygenase Promotes Proliferation and Metastasis in Triple-Negative Breast Cancers. PMID:33887987
Epidermal growth factor receptor regulates fibrinolytic pathway elements in cervical cancer: functional and prognostic implications. PMID:33886813
Impact of splicing mutations in acute myeloid leukemia treated with hypomethylating agents combined with venetoclax. PMID:33885753
Familial Lipomas Without Classic Neurofibromatosis-1 Caused by a Missense Germline NF1 Mutation. PMID:33884301
Gene Expression and Data Analysis Pipeline Using Cancer BioPortal in the Classroom. PMID:33884053
Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer. PMID:33883167
PTEN mutations predict benefit from tumor treating fields (TTFields) therapy in patients with recurrent glioblastoma. PMID:33881725
Bioinformatics and In Vitro Studies Reveal the Importance of p53, PPARG and Notch Signaling Pathway in Inhibition of Breast Cancer Stem Cells by Hesperetin. PMID:33880358
MicroRNA-302s Might Regulate ARL4C-Mediated Gastric Cancer Progression via p53 Signaling: Bioinformatics Analysis and Experiments Validation. PMID:33880033
Identification of prognostic biomarkers associated with the occurrence of portal vein tumor thrombus in hepatocellular carcinoma. PMID:33878734
14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia. PMID:33876209
High estrogen receptor alpha activation confers resistance to estrogen deprivation and is required for therapeutic response to estrogen in breast cancer. PMID:33875787
The Metabolic Landscape of RAS-Driven Cancers from biology to therapy. PMID:33870211
A Non-canonical Wnt Signature Correlates With Lower Survival in Gastric Cancer. PMID:33869179
LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton. PMID:33869174
Mutated DNA Damage Repair Pathways Are Prognostic and Chemosensitivity Markers for Resected Colorectal Cancer Liver Metastases. PMID:33869034
Algorithm-Based Meta-Analysis Reveals the Mechanistic Interaction of the Tumor Suppressor LIMD1 With Non-Small-Cell Lung Carcinoma. PMID:33869018
The CSRNP Gene Family Serves as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma. PMID:33869003
DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression. PMID:33868478
Cytotoxic T-lymphocyte infiltration and chemokine predict long-term patient survival independently of tumor mutational burden in triple-negative breast cancer. PMID:33868461
multiSLIDE is a web server for exploring connected elements of biological pathways in multi-omics data. PMID:33863886
IκBα targeting promotes oxidative stress-dependent cell death. PMID:33863364
A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial. PMID:33862582
CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells. PMID:33861751
FCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress. PMID:33859174
The dystonia gene THAP1 controls DNA double-strand break repair choice. PMID:33857404
Systematic analysis of the function and prognostic value of RNA binding proteins in Colon Adenocarcinoma. PMID:33854615
CRL4AMBRA1 is a master regulator of D-type cyclins. PMID:33854235
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. PMID:33854232
Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer. PMID:33853832
Characteristics and prognostic value of potential dependency genes in clear cell renal cell carcinoma based on a large-scale CRISPR-Cas9 and RNAi screening database DepMap. PMID:33850477
SCAMP3 is a mutant EGFR phosphorylation target and a tumor suppressor in lung adenocarcinoma. PMID:33850265
CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BRAF-mutated colorectal cancers. PMID:33846570
Overexpressing PTTG family genes predict poor prognosis in kidney renal clear cell carcinoma. PMID:33845847
A cell-to-patient machine learning transfer approach uncovers novel basal-like breast cancer prognostic markers amongst alternative splice variants. PMID:33845831
Epigenetic and metabolic interplay in cutaneous squamous cell carcinoma. PMID:33844325
mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 Are Druggable Candidates for N-(2,4-Difluorophenyl)-2',4'-Difluoro-4-Hydroxybiphenyl-3-Carboxamide (NSC765598), With Consequent Anticancer Implications. PMID:33842373
Colony Stimulating Factor 1 Receptor in Acute Myeloid Leukemia. PMID:33842370
CDKN2A Deletion in Melanoma Excludes T Cell Infiltration by Repressing Chemokine Expression in a Cell Cycle-Dependent Manner. PMID:33842347
Musashi 2 (MSI2) expression as an independent prognostic biomarker in non-small cell lung cancer (NSCLC). PMID:33841930
Nuclear factor IB is downregulated in vulvar squamous cell carcinoma (VSCC): Unravelling differentially expressed genes in VSCC through gene expression dataset analysis. PMID:33841565
Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma. PMID:33840169
Beyond Programmed Death-Ligand 1: B7-H6 Emerges as a Potential Immunotherapy Target in SCLC. PMID:33839362
Whole-exome sequencing reveals the etiology of the rare primary hepatic mucoepidermoid carcinoma. PMID:33832503
Genomic characterization of small cell carcinomas of the uterine cervix. PMID:33830625
Prognostic and therapeutic implications of extracellular matrix associated gene signature in renal clear cell carcinoma. PMID:33828127
Pan-genomic characterization of high-risk pediatric papillary thyroid carcinoma. PMID:33827048
Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapy. PMID:33822841
Vitamin D receptor upregulates lncRNA TOPORS-AS1 which inhibits the Wnt/β-catenin pathway and associates with favorable prognosis of ovarian cancer. PMID:33820921
A bioinformatic analysis of the inhibin-betaglycan-endoglin/CD105 network reveals prognostic value in multiple solid tumors. PMID:33819300
Growth Hormone/Insulin Growth Factor Axis in Sex Steroid Associated Disorders and Related Cancers. PMID:33816477
Identification of a Six Gene Prognosis Signature for Papillary Thyroid Cancer Using Multi-Omics Methods and Bioinformatics Analysis. PMID:33816258
Comprehensive Analysis of the Prognosis and Correlations With Immune Infiltration of S100 Protein Family Members in Hepatocellular Carcinoma. PMID:33815482
Comprehensive Analysis of APA Events and Their Association With Tumor Microenvironment in Lung Adenocarcinoma. PMID:33815479
A circular network of coregulated sphingolipids dictates lung cancer growth and progression. PMID:33813137
Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first-line platinum chemotherapy in high grade serous ovarian cancer. PMID:33811746
Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome. PMID:33811546
Constitutional 2p16.3 deletion including MSH6 and FBXO11 in a boy with developmental delay and diffuse large B-cell lymphoma. PMID:33811277
The Association between TIF1 Family Members and Cancer Stemness in Solid Tumors. PMID:33810347
The Extracellular Small Leucine-Rich Proteoglycan Biglycan Is a Key Player in Gastric Cancer Aggressiveness. PMID:33809543
Aberrations of Chromosomes 1 and 16 in Breast Cancer: A Framework for Cooperation of Transcriptionally Dysregulated Genes. PMID:33808143
The CXCL2/IL8/CXCR2 Pathway Is Relevant for Brain Tumor Malignancy and Endothelial Cell Function. PMID:33807899
More Than Meets the Eye: Revisiting the Roles of Heat Shock Factor 4 in Health and Diseases. PMID:33807297
Gene Co-Expression Analysis of Human RNASEH2A Reveals Functional Networks Associated with DNA Replication, DNA Damage Response, and Cell Cycle Regulation. PMID:33805806
Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development-Review. PMID:33805800
Annexin A1 Expression Is Associated with Epithelial-Mesenchymal Transition (EMT), Cell Proliferation, Prognosis, and Drug Response in Pancreatic Cancer. PMID:33804148
Candidate Markers of Olaparib Response from Genomic Data Analyses of Human Cancer Cell Lines. PMID:33803939
The MEK1/2 Pathway as a Therapeutic Target in High-Grade Serous Ovarian Carcinoma. PMID:33803586
CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma. PMID:33803245
A Detailed Catalogue of Multi-Omics Methodologies for Identification of Putative Biomarkers and Causal Molecular Networks in Translational Cancer Research. PMID:33802234
Linking Serine/Glycine Metabolism to Radiotherapy Resistance. PMID:33801846
Crk and CrkL as Therapeutic Targets for Cancer Treatment. PMID:33801580
Pathogenic Roles of S100A8 and S100A9 Proteins in Acute Myeloid and Lymphoid Leukemia: Clinical and Therapeutic Impacts. PMID:33801279
The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases. PMID:33800554
An In Silico Analysis Identified FZD9 as a Potential Prognostic Biomarker in Triple-Negative Breast Cancer Patients. PMID:33796830
Integrative Analysis of the Expression of SIGLEC Family Members in Lung Adenocarcinoma via Data Mining. PMID:33796453
Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways. PMID:33795256
The m6A Reader YTHDF1 Facilitates the Tumorigenesis and Metastasis of Gastric Cancer via USP14 Translation in an m6A-Dependent Manner. PMID:33791305
ARRDC3 as a Diagnostic and Prognostic Biomarker for Epithelial Ovarian Cancer Based on Data Mining. PMID:33790626
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. PMID:33789117
BCL2L2 loss renders -14q renal cancer dependent on BCL2L1 that mediates resistance to tyrosine kinase inhibitors. PMID:33784008
Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis. PMID:33783919
Biochemical and structural characterization of analogs of MRE11 breast cancer-associated mutant F237C. PMID:33782469
Immune modulation underpins the anti-cancer activity of HDAC inhibitors. PMID:33773029
Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer. PMID:33771885
Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity. PMID:33768207
Does Subtelomeric Position of COMMD5 Influence Cancer Progression? PMID:33768002
CXC Chemokines as Therapeutic Targets and Prognostic Biomarkers in Skin Cutaneous Melanoma Microenvironment. PMID:33767987
IP6K2 predicts favorable clinical outcome of primary breast cancer. PMID:33767863
Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation. PMID:33767702
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway. PMID:33767426
Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids. PMID:33767160
A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells. PMID:33763657
Pan-cancer image-based detection of clinically actionable genetic alterations. PMID:33763651
High KIFC1 expression is associated with poor prognosis in prostate cancer. PMID:33760984
Single-cell analysis reveals metastatic cell heterogeneity in clear cell renal cell carcinoma. PMID:33759378
Overexpression of Taspase 1 Predicts Poor Prognosis in Patients with Hepatocellular Carcinoma. PMID:33758547
CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation. PMID:33758365
Overexpression of CCNE1 confers a poorer prognosis in triple-negative breast cancer identified by bioinformatic analysis. PMID:33757543
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. PMID:33756106
Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer. PMID:33756102
LIN28B induces a differentiation program through CDX2 in colon cancer. PMID:33755595
In search for biomarkers and potential drug targets for uterine serous endometrial cancer. PMID:33754208
The origins and genetic interactions of KRAS mutations are allele- and tissue-specific. PMID:33753749
The NFIB-ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells. PMID:33751828
NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer. PMID:33750924
Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3. PMID:33749896
Comprehensive Analysis of the Immune and Prognostic Implication of COL6A6 in Lung Adenocarcinoma. PMID:33747955
Immune Modeling Analysis Reveals Immunologic Signatures Associated With Improved Outcomes in High Grade Serous Ovarian Cancer. PMID:33747935
Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma. PMID:33747576
Identification of Prognostic and Therapeutic Biomarkers among FAM83 Family Members for Pancreatic Ductal Adenocarcinoma. PMID:33747255
miR-130a-3p promotes cell proliferation and invasion by targeting estrogen receptor α and androgen receptor in cervical cancer. PMID:33747155
Cutaneous Melanoma: Mutational Status and Potential Links to Tertiary Lymphoid Structure Formation. PMID:33746966
Pan-cancer analysis identifies ITIH1 as a novel prognostic indicator for hepatocellular carcinoma. PMID:33744857
Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis. PMID:33743547
Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis. PMID:33742106
Targeted Proteomic Analysis Revealed Kinome Reprogramming during Acquisition of Radioresistance in Breast Cancer Cells. PMID:33739118
Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease. PMID:33738287
TFEB Promotes Prostate Cancer Progression via Regulating ABCA2-Dependent Lysosomal Biogenesis. PMID:33732651
FAM83A and FAM83A-AS1 both play oncogenic roles in lung adenocarcinoma. PMID:33732373
ERBB1/2/3 Expression, Prognosis, and Immune Infiltration in Cutaneous Melanoma. PMID:33732282
Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress. PMID:33731803
Pol α-primase dependent nuclear localization of the mammalian CST complex. PMID:33731801
The clinical significance of CTC enrichment by GPC3-IML and its genetic analysis in hepatocellular carcinoma. PMID:33726759
CRISPR screens identify tumor-promoting genes conferring melanoma cell plasticity and resistance. PMID:33724679
ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments. PMID:33724652
Molecular features of untreated breast cancer and initial metastatic event inform clinical decision-making and predict outcome: long-term results of ESOPE, a single-arm prospective multicenter study. PMID:33722295
Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive (IDHwt) glioma is associated with H3K27me3 depletion and alternative promoter usage. PMID:33720519
G6PD-NF-κB-HGF Signal in Gastric Cancer-Associated Mesenchymal Stem Cells Promotes the Proliferation and Metastasis of Gastric Cancer Cells by Upregulating the Expression of HK2. PMID:33718248
Tumor Molecular Features Predict Endometrial Cancer Patients' Survival After Open or Minimally Invasive Surgeries. PMID:33718224
DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells. PMID:33718139
Hypocrisy Around Medical Patient Data: Issues of Access for Biomedical Research, Data Quality, Usefulness for the Purpose and Omics Data as Game Changer. PMID:33717311
Do Molecular Profiles of Primary Versus Metastatic Radioiodine Refractory Differentiated Thyroid Cancer Differ? PMID:33716974
Advanced Approaches to Breast Cancer Classification and Diagnosis. PMID:33716731
Comprehensive analysis of expression and prognostic value of the claudin family in human breast cancer. PMID:33714203
Integrative analysis regarding the correlation between GAS2 family genes and human glioma prognosis. PMID:33713047
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. PMID:33712589
A comprehensive molecular characterization of the 8q22.2 region reveals the prognostic relevance of OSR2 mRNA in muscle invasive bladder cancer. PMID:33711044
Androgen receptor (AR) antagonism triggers acute succinate-mediated adaptive responses to reactivate AR signaling. PMID:33709547
Establishment of Novel DNA Methylation-Based Prostate Cancer Subtypes and a Risk-Predicting Eight-Gene Signature. PMID:33708770
Increased expression of MCM4 is associated with poor prognosis in patients with hepatocellular carcinoma. PMID:33708433
Identification of TRIM56 as a Potential Biomarker for Lung Adenocarcinoma. PMID:33707970
Differential alternative RNA splicing and transcription events between tumors from African American and White patients in The Cancer Genome Atlas. PMID:33705884
Theragnostic chromosomal rearrangements in treatment-naive pancreatic ductal adenocarcinomas obtained via endoscopic ultrasound. PMID:33704908
Significant non-existence of sequences in genomes and proteomes. PMID:33693858
Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair. PMID:33692124
In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer. PMID:33691672
Interferon regulatory factor 1(IRF-1) activates anti-tumor immunity via CXCL10/CXCR3 axis in hepatocellular carcinoma (HCC). PMID:33689775
Identification and Validation of Key Genes in Hepatocellular Carcinoma by Bioinformatics Analysis. PMID:33688500
FOXQ1 is Differentially Expressed Across Breast Cancer Subtypes with Low Expression Associated with Poor Overall Survival. PMID:33688250
An Apoptotic Gene Signature for the Prognosis of Hepatocellular Carcinoma. PMID:33688206
Partial Response to Pyrotinib Plus Capecitabine in an Advanced Breast Cancer Patient with HER2 Amplification and R157W Mutation After Anti-HER2 Treatment: A Case Report and Literature Review. PMID:33688205
FAM72 serves as a biomarker of poor prognosis in human lung adenocarcinoma. PMID:33686947
Potential role of glucosamine-phosphate N-acetyltransferase 1 in the development of lung adenocarcinoma. PMID:33686019
Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors. PMID:33685991
Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with EGFR Exon 20 Insertions. PMID:33685865
Deciphering the genetic alterations in matrix metallo-proteinase gene family and its putative association with head and neck squamous cell carcinoma. PMID:33681393
The Prognostic Value and Mechanisms of TMEM16A in Human Cancer. PMID:33681289
CD96 Correlates With Immune Infiltration and Impacts Patient Prognosis: A Pan-Cancer Analysis. PMID:33680972
KRAS mutation in pancreatic cancer. PMID:33676749
LY6K-AS lncRNA is a lung adenocarcinoma prognostic biomarker and regulator of mitotic progression. PMID:33674747
Molecular characterization of high-grade serous ovarian cancers occurring in younger and older women. PMID:33674143
Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer. PMID:33673346
Receptor Tyrosine Kinase Signaling and Targeting in Glioblastoma Multiforme. PMID:33673213
Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer. PMID:33671201
Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics. PMID:33670680
Downregulation of Cell Cycle and Checkpoint Genes by Class I HDAC Inhibitors Limits Synergism with G2/M Checkpoint Inhibitor MK-1775 in Bladder Cancer Cells. PMID:33670166
Regulation of p53 by E3s. PMID:33670160
Multi-Omics Data Analysis of Gene Expressions and Alterations, Cancer-Associated Fibroblast and Immune Infiltrations, Reveals the Onco-Immune Prognostic Relevance of STAT3/CDK2/4/6 in Human Malignancies. PMID:33668805
Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer. PMID:33667385
E2F1: Cause and Consequence of DNA Replication Stress. PMID:33665206
Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients. PMID:33662628
Pan-cancer investigation reveals mechanistic insights of planar cell polarity gene Fuz in carcinogenesis. PMID:33658400
The aging-related risk signature in colorectal cancer. PMID:33658390
MMP7 as a potential biomarker of colon cancer and its prognostic value by bioinformatics analysis. PMID:33655961
Integration of comprehensive genomic profiling, tumor mutational burden, and PD-L1 expression to identify novel biomarkers of immunotherapy in non-small cell lung cancer. PMID:33655698
MIG-6 is essential for promoting glucose metabolic reprogramming and tumor growth in triple-negative breast cancer. PMID:33655623
Refining the Molecular Framework for Pancreatic Cancer with Single-cell and Spatial Technologies. PMID:33653818
LRP1B mutations are associated with favorable outcomes to immune checkpoint inhibitors across multiple cancer types. PMID:33653800
Protocol for proteogenomic dissection of intronic splicing enhancer interactome for prediction of individualized cancer prognosis. PMID:33644773
Enolase 1 Correlated With Cancer Progression and Immune-Infiltrating in Multiple Cancer Types: A Pan-Cancer Analysis. PMID:33643901
Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer. PMID:33643710
Integrated Analysis of the Prognosis-Associated RNA-Binding Protein Genes and Candidate Drugs in Renal Papillary Cell Carcinoma. PMID:33643390
TMEM52B suppression promotes cancer cell survival and invasion through modulating E-cadherin stability and EGFR activity. PMID:33641663
Comprehensive Review of Molecular Mechanisms and Clinical Features of Invasive Lobular Cancer. PMID:33641217
Mutation-based clustering and classification analysis reveals distinctive age groups and age-related biomarkers for glioma. PMID:33639927
Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors. PMID:33637626
Activated ALK Cooperates with N-Myc via Wnt/β-Catenin Signaling to Induce Neuroendocrine Prostate Cancer. PMID:33637566
Pancreatic ductal adenocarcinoma in the era of precision medicine. PMID:33637355
Clinical benefit for clinical sequencing using cancer panel testing. PMID:33635883
Longitudinal CTCs gene expression analysis on metastatic castration-resistant prostate cancer patients treated with docetaxel reveals new potential prognosis markers. PMID:33635497
The Role of Interleukin-33 in Head and Neck Squamous Cell Carcinoma Is Determined by Its Cellular Sources in the Tumor Microenvironment. PMID:33634017
CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer. PMID:33633150
Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection. PMID:33632928
Comprehensive molecular profiling of Taiwanese breast cancers revealed potential therapeutic targets: prevalence of actionable mutations among 380 targeted sequencing analyses. PMID:33632156
Sparse data embedding and prediction by tropical matrix factorization. PMID:33632116
Identification BCL6 and miR-30 family associating with Ibrutinib resistance in activated B-cell-like diffuse large B-cell lymphoma. PMID:33629212
Exploration of Prognostic Biomarkers among Replication Factor C Family in the Hepatocellular Carcinoma. PMID:33628006
OncoTree: A Cancer Classification System for Precision Oncology. PMID:33625877
How to Use Online Tools to Generate New Hypotheses for Mammary Gland Biology Research: A Case Study for Wnt7b. PMID:33625717
Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes. PMID:33622998
Genetic and molecular subtype heterogeneity in newly diagnosed early- and advanced-stage endometrial cancer. PMID:33622519
Systematic analysis of the expression and prognosis relevance of FBXO family reveals the significance of FBXO1 in human breast cancer. PMID:33622332
High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability. PMID:33622270
Interleukin-33 modulates immune responses in cutaneous melanoma in a context-specific way. PMID:33621202
Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A. PMID:33621062
Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1. PMID:33619228
A Risk Prediction Model for Breast Cancer Based on Immune Genes Related to Early Growth Response Proteins Family. PMID:33614706
Autophagy Gene Panel-Based Prognostic Model in Myelodysplastic Syndrome. PMID:33614490
Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma. PMID:33613844
High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma. PMID:33613843
Transcription factor E2F4 is an indicator of poor prognosis and is related to immune infiltration in hepatocellular carcinoma. PMID:33613768
Identification of a Metastasis-Associated Gene Signature of Clear Cell Renal Cell Carcinoma. PMID:33613617
Functional Prediction of Long Noncoding RNAs in Cutaneous Melanoma Using a Systems Biology Approach. PMID:33613027
The PD-L1 metabolic interactome intersects with choline metabolism and inflammation. PMID:33608051
Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data. PMID:33606788
Comprehensive Analysis of Prognostic and Immune Infiltrates for E2F Transcription Factors in Human Pancreatic Adenocarcinoma. PMID:33604289
Identification of potential therapeutic target of naringenin in breast cancer stem cells inhibition by bioinformatics and in vitro studies. PMID:33603536
Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression. PMID:33603163
Spatial Analysis and Clinical Significance of HLA Class-I and Class-II Subunit Expression in Non-Small Cell Lung Cancer. PMID:33602682
A distinct repertoire of cancer-associated fibroblasts is enriched in cribriform prostate cancer. PMID:33600062
Double inhibition and activation mechanisms of Ephexin family RhoGEFs. PMID:33597305
Identification of lipidomic profiles associated with drug-resistant prostate cancer cells. PMID:33596934
Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer. PMID:33596246
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity. PMID:33594203
The ADRB1 (Adrenoceptor Beta 1) and ADRB2 genes significantly co-express with commonly mutated genes in prostate cancer. PMID:33593484
Comprehensive analysis of macrophage-related multigene signature in the tumor microenvironment of head and neck squamous cancer. PMID:33592580
USP13 regulates the replication stress response by deubiquitinating TopBP1. PMID:33592542
Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. PMID:33591981
Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. PMID:33588911
Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer. PMID:33585209
The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype. PMID:33585078
Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions. PMID:33581682
Predicted 'wiring landscape' of Ras-effector interactions in 29 human tissues. PMID:33580066
Clinically significant genomic alterations in the Chinese and Western patients with intrahepatic cholangiocarcinoma. PMID:33579226
Toll-Like Receptor 7 Mediates Inflammation Resolution and Inhibition of Angiogenesis in Non-Small Cell Lung Cancer. PMID:33578955
Differential Expression of a Panel of Ten CNTN1-Associated Genes during Prostate Cancer Progression and the Predictive Properties of the Panel Towards Prostate Cancer Relapse. PMID:33578925
Integrative Genomic Analyses of Patient-Matched Intracranial and Extracranial Metastases Reveal a Novel Brain-Specific Landscape of Genetic Variants in Driver Genes of Malignant Melanoma. PMID:33578810
NG-Circos: next-generation Circos for data visualization and interpretation. PMID:33575618
Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers. PMID:33575259
Screening and identification of hub genes in bladder cancer by bioinformatics analysis and KIF11 is a potential prognostic biomarker. PMID:33574944
CC Chemokine Receptors in Lung Adenocarcinoma: The Inflammation-Related Prognostic Biomarkers and Immunotherapeutic Targets. PMID:33574689
Hematologic indices in individuals with pathogenic germline DICER1 variants. PMID:33570641
Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes. PMID:33568675
Analysis of the role of Frizzled 2 in different cancer types. PMID:33565732
Integrated bioinformatic analysis identifies COL4A3, COL4A4, and KCNJ1 as key biomarkers in Wilms tumor. PMID:33564352
Expression of cell divisioncycle-associated genes and their prognostic significance in hepatocellular carcinoma. PMID:33564348
ACE2 Is a Prognostic Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma: Implication for COVID-19. PMID:33564310
Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder. PMID:33563892
Inhibition of relaxin autocrine signaling confers therapeutic vulnerability in ovarian cancer. PMID:33561012
Differential immune signatures in the tumor microenvironment are associated with colon cancer racial disparities. PMID:33560598
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide. PMID:33558541
Pan-Cancer Analysis Shows TP53 Mutations Modulate the Association of NOX4 with Genetic Programs of Cancer Progression and Clinical Outcome. PMID:33557266
Personalized oncology and BRAFK601N melanoma: model development, drug discovery, and clinical correlation. PMID:33555379
Toll-like receptor 4 signaling activates ERG function in prostate cancer and provides a therapeutic target. PMID:33554122
Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer. PMID:33553736
Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer. PMID:33553693
Genetic Architectures and Cell-of-Origin in Glioblastoma. PMID:33552990
Suppression of p16 alleviates the senescence-associated secretory phenotype. PMID:33550279
The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer. PMID:33548228
Crystal structure of the human PRPK-TPRKB complex. PMID:33547416
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma. PMID:33547292
Prostate cancer. PMID:33542230
Evolutionary Conservation of Structural and Functional Coupling between the BRM AT-Hook and Bromodomain. PMID:33539881
Elevated NSD3 histone methylation activity drives squamous cell lung cancer. PMID:33536620
A short deletion in the DNA-binding domain of STAT3 suppresses growth and progression of colon cancer cells. PMID:33535185
Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling. PMID:33531625
The ER stress response mediator ERO1 triggers cancer metastasis by favoring the angiogenic switch in hypoxic conditions. PMID:33531624
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer. PMID:33531470
Hierarchical tumor heterogeneity mediated by cell contact between distinct genetic subclones. PMID:33529175
SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. PMID:33527896
Proteasomal Regulation of Mammalian SPT16 in Controlling Transcription. PMID:33526453
Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling. PMID:33526450
Reuse of Molecules for Glioblastoma Therapy. PMID:33525329
Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden. PMID:33523857
LAPTM5 Plays a Key Role in the Diagnosis and Prognosis of Testicular Germ Cell Tumors. PMID:33521125
NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription. PMID:33520407
Epigenetically silenced linc00261 contributes to the metastasis of hepatocellular carcinoma via inducing the deficiency of FOXA2 transcription. PMID:33520374
Generating Ensembles of Gene Regulatory Networks to Assess Robustness of Disease Modules. PMID:33519907
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer. PMID:33517887
Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding. PMID:33515600
The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo. PMID:33514834
My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype. PMID:33514395
Restoring the DREAM Complex Inhibits the Proliferation of High-Risk HPV Positive Human Cells. PMID:33513914
Integrin α3β1 Promotes Invasive and Metastatic Properties of Breast Cancer Cells through Induction of the Brn-2 Transcription Factor. PMID:33513758
ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models. PMID:33512452
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer. PMID:33509944
Molecular and immune signature of HPV-positive oral cavity squamous cell carcinoma. PMID:33509683
OIP5-AS1 specifies p53-driven POX transcription regulated by TRPC6 in glioma. PMID:33508123
Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases. PMID:33507258
Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors. PMID:33506979
Tumor Profiling at the Service of Cancer Therapy. PMID:33505911
Dissecting the Invasion-Associated Long Non-coding RNAs Using Single-Cell RNA-Seq Data of Glioblastoma. PMID:33505440
Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression. PMID:33504618
K3326X and Other C-Terminal BRCA2 Variants Implicated in Hereditary Cancer Syndromes: A Review. PMID:33503928
Comprehensive analysis of PLOD family members in low-grade gliomas using bioinformatics methods. PMID:33503035
High LARGE1 Expression May Predict Benefit from Adjuvant Chemotherapy in Resected Non-Small-Cell Lung Cancer. PMID:33500650
Effective Prediction of Prostate Cancer Recurrence through the IQGAP1 Network. PMID:33498739
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. PMID:33497611
An improved assay for detection of theranostic gene translocations and MET exon 14 skipping in thoracic oncology. PMID:33495574
Identification of therapeutic targets and prognostic biomarkers from the hnRNP family in invasive breast carcinoma. PMID:33495416
Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis. PMID:33495413
Immune Resistance in Lung Adenocarcinoma. PMID:33494181
Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers. PMID:33493140
Expression and prognostic analyses of SCAMPs in pancreatic adenocarcinoma. PMID:33493138
Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma. PMID:33493134
MYBL2-Driven Transcriptional Programs Link Replication Stress and Error-prone DNA Repair With Genomic Instability in Lung Adenocarcinoma. PMID:33489883
Analysis of the Prognosis and Therapeutic Value of the CXC Chemokine Family in Head and Neck Squamous Cell Carcinoma. PMID:33489879
BRAF AMP Frequently Co-occurs With IDH1/2, TP53, and ATRX Mutations in Adult Patients With Gliomas and Is Associated With Poorer Survival Than That of Patients Harboring BRAF V600E. PMID:33489866
Oncogenes in high grade serous adenocarcinoma of the ovary. PMID:33488950
Combined Serum DKK3 and Circulating CD133 Cells as Prognostic Biomarkers for Ovarian Cancer Patients. PMID:33488097
KYNU, a novel potential target that underpins CD44-promoted breast tumour cell invasion. PMID:33486887
Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia. PMID:33485366
The clinicopathological significance of SWI/SNF alterations in gastric cancer is associated with the molecular subtypes. PMID:33481850
Online informatics resources to facilitate cancer target and chemical probe discovery. PMID:33479663
L-Selectin expression is associated with inflammatory microenvironment and favourable prognosis in breast cancer. PMID:33479593
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer. PMID:33479498
Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells. PMID:33475085
Liquid biopsy enters the clinic - implementation issues and future challenges. PMID:33473219
Identification of Prognostic Biomarkers and Molecular Targets Among JAK Family in Breast Cancer. PMID:33469338
Triple-Negative Breast Cancer and the COVID-19 Pandemic: Clinical Management Perspectives and Potential Consequences of Infection. PMID:33467411
Immunogenomic Gene Signature of Cell-Death Associated Genes with Prognostic Implications in Lung Cancer. PMID:33466402
Mechanisms of Resistance to KRASG12C Inhibitors. PMID:33466360
Molecular Changes in Retinoblastoma beyond RB1: Findings from Next-Generation Sequencing. PMID:33466343
Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma. PMID:33461580
Inflammation Is Associated with Worse Outcome in the Whole Cohort but with Better Outcome in Triple-Negative Subtype of Breast Cancer Patients. PMID:33457427
Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer. PMID:33457104
MRPL27 contributes to unfavorable overall survival and disease-free survival from cholangiocarcinoma patients. PMID:33456351
NOTCH3, a crucial target of miR-491-5p/miR-875-5p, promotes gastric carcinogenesis by upregulating PHLDB2 expression and activating Akt pathway. PMID:33452458
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair. PMID:33452241
Secretoglobin 3A2 eliminates human cancer cells through pyroptosis. PMID:33452234
AhR and Cancer: From Gene Profiling to Targeted Therapy. PMID:33451095
The pioneer and differentiation factor FOXA2 is a key driver of yolk-sac tumour formation and a new biomarker for paediatric and adult yolk-sac tumours. PMID:33448076
Correlation of genomic alterations and PD-L1 expression in thymoma. PMID:33447447
Genomic alterations in thymoma-molecular pathogenesis? PMID:33447444
CD117/c-kit defines a prostate CSC-like subpopulation driving progression and TKI resistance. PMID:33446896
Characterization of SOX2, OCT4 and NANOG in Ovarian Cancer Tumor-Initiating Cells. PMID:33445692
Combined assay of Circulating Tumor DNA and Protein Biomarkers for early noninvasive detection and prognosis of Non-Small Cell Lung Cancer. PMID:33442424
Lipid droplet biogenesis and COX-2 pathway activation are triggered by Barrett's esophagus and adenocarcinoma, but not esophageal squamous cell carcinoma risk factors. PMID:33441691
Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy. PMID:33441554
Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis. PMID:33441543
Chromatin-regulating genes are associated with postoperative prognosis and isocitrate dehydrogenase mutation in astrocytoma. PMID:33437793
Prognosis Prediction for Colorectal Cancer Patients: A Risk Score Based on The Metabolic-Related Genes. PMID:33437216
Integrate analysis of the promote function of Cell division cycle-associated protein family to pancreatic adenocarcinoma. PMID:33437202
Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers. PMID:33436826
PI3KCA Mutations in Uterine Cervix Carcinoma. PMID:33435133
Exploration of Coding and Non-coding Variants in Cancer Using GenomePaint. PMID:33434514
Mass spectrometry-based protein-protein interaction networks for the study of human diseases. PMID:33434350
Cell-Intrinsic Tumorigenic Functions of PPARγ in Bladder Urothelial Carcinoma. PMID:33431608
Context Matters: NOTCH Signatures and Pathway in Cancer Progression and Metastasis. PMID:33430387
Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2). PMID:33428613
An Integrative Pan-Cancer Analysis Revealing LCN2 as an Oncogenic Immune Protein in Tumor Microenvironment. PMID:33425761
Downregulation of Brain Enriched Type 2 MAGEs Is Associated With Immune Infiltration and Poor Prognosis in Glioma. PMID:33425727
PD-L1 and PD-L2 Expression in Cervical Cancer: Regulation and Biomarker Potential. PMID:33424844
A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance. PMID:33420373
Assessing ZNF154 methylation in patient plasma as a multicancer marker in liquid biopsies from colon, liver, ovarian and pancreatic cancer patients. PMID:33420235
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. PMID:33417831
miRNA‑490‑3p promotes the metastatic progression of invasive ductal carcinoma. PMID:33416185
Classify multicategory outcome in patients with lung adenocarcinoma using clinical, transcriptomic and clinico-transcriptomic data: machine learning versus multinomial models. PMID:33415023
Oncogene UBE2I enhances cellular invasion, migration and proliferation abilities via autophagy-related pathway resulting in poor prognosis in hepatocellular carcinoma. PMID:33414994
Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth. PMID:33414169
Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway. PMID:33412308
Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer. PMID:33407715
Development of nomogram based on immune-related gene FGFR4 for advanced non-small cell lung cancer patients with sensitivity to immune checkpoint inhibitors. PMID:33407583
Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein. PMID:33405952
An Integrated Platform for Skin Cancer Heterogenous and Multilayered Data Management. PMID:33404959
Prognostic implication of glycolysis related gene signature in non-small cell lung cancer. PMID:33403045
Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway. PMID:33403043
Identification of Seven Cell Cycle-Related Genes with Unfavorable Prognosis and Construction of their TF-miRNA-mRNA regulatory network in Breast Cancer. PMID:33403032
BRCA1/2 pathogenic variants in triple-negative versus luminal-like breast cancers: genotype-phenotype correlation in a cohort of 531 patients. PMID:33403015
Identification of a novel six autophagy-related genes signature for the prognostic and a miRNA-related autophagy predictor for anti-PD-1 therapy responses in prostate cancer. PMID:33402116
Targeting Lymphotoxin Beta and Paired Box 5: a potential therapeutic strategy for soft tissue sarcoma metastasis. PMID:33397394
The Impact of Immunofunctional Phenotyping on the Malfunction of the Cancer Immunity Cycle in Breast Cancer. PMID:33396390
Cyclin-dependent Kinase 1 and Aurora Kinase choreograph mitotic storage and redistribution of a growth factor receptor. PMID:33395410
Interplay Between EGFR and the Platelet-Activating Factor/PAF Receptor Signaling Axis Mediates Aggressive Behavior of Cervical Cancer. PMID:33392068
Loss of LIMCH1 predicts poor prognosis in patients with surgically resected Lung Adenocarcinoma: A study based on Immunohistochemical Analysis and Bioinformatics. PMID:33391414
Using The Cancer Genome Atlas as an Inquiry Tool in the Undergraduate Classroom. PMID:33391340
Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma. PMID:33390805
Discovery of acquired molecular signature on immune checkpoint inhibitors in paired tumor tissues. PMID:33389015
Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency. PMID:33385162
Functional Gene Expression Differentiation of the Notch Signaling Pathway in Female Reproductive Tract Tissues-A Comprehensive Review With Analysis. PMID:33384996
HOXA5 Expression Is Elevated in Breast Cancer and Is Transcriptionally Regulated by Estradiol. PMID:33384715
Genomic and transcriptomic landscape of conjunctival melanoma. PMID:33383577
Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer. PMID:33383310
HeartBioPortal2.0: new developments and updates for genetic ancestry and cardiometabolic quantitative traits in diverse human populations. PMID:33382884
Validation of CSN1S1 transcriptional expression, promoter methylation, and prognostic power in breast cancer using independent datasets. PMID:33381666
Expression, Prognosis, and Immune Infiltrates Analyses of E2Fs in Human Brain and CNS Cancer. PMID:33381564
Risk Stratification in Acute Myeloid Leukemia Using CXCR Gene Signatures: A Bioinformatics Analysis. PMID:33381455
Targeting BRD9 for Cancer Treatment: A New Strategy. PMID:33380808
Effect of let-7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma. PMID:33376529
Characterizing TP53 mutations in ovarian carcinomas with and without concurrent BRCA1 or BRCA2 mutations. PMID:33375991
AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer? PMID:33375416
Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer. PMID:33375283
High Risk α-HPV E6 Impairs Translesion Synthesis by Blocking POLη Induction. PMID:33374731
High Expression of NRF2 Is Associated with Increased Tumor-Infiltrating Lymphocytes and Cancer Immunity in ER-Positive/HER2-Negative Breast Cancer. PMID:33371179
Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma. PMID:33369458
Transcription factor networks of oligodendrogliomas treated with adjuvant radiotherapy or observation inform prognosis. PMID:33367753
m5C RNA Methylation Primarily Affects the ErbB and PI3K-Akt Signaling Pathways in Gastrointestinal Cancer. PMID:33365328
Overexpression of rhophilin 2 promotes pancreatic ductal adenocarcinoma. PMID:33365087
Four Immune-Related Long Non-coding RNAs for Prognosis Prediction in Patients With Hepatocellular Carcinoma. PMID:33364253
Bioinformatics Analysis of the Prognostic and Biological Significance of ZDHHC-Protein Acyltransferases in Kidney Renal Clear Cell Carcinoma. PMID:33364189
Identification and Validation of the N6-Methyladenosine RNA Methylation Regulator YTHDF1 as a Novel Prognostic Marker and Potential Target for Hepatocellular Carcinoma. PMID:33363211
Systematic Analysis of Expression Profiles and Prognostic Significance for FAM83 Family in Non-small-Cell Lung Cancer. PMID:33363204
PD-L1 Is a Tumor Suppressor in Aggressive Endometrial Cancer Cells and Its Expression Is Regulated by miR-216a and lncRNA MEG3. PMID:33363153
AUNIP Expression Is Correlated With Immune Infiltration and Is a Candidate Diagnostic and Prognostic Biomarker for Hepatocellular Carcinoma and Lung Adenocarcinoma. PMID:33363020
Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer. PMID:33363011
State of the Field in Multi-Omics Research: From Computational Needs to Data Mining and Sharing. PMID:33362867
OCTAD: an open workspace for virtually screening therapeutics targeting precise cancer patient groups using gene expression features. PMID:33361798
The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress. PMID:33359448
Identification of Prognostic Genes and Pathways in Lung Adenocarcinoma Using a Bayesian Approach. PMID:33354107
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences. PMID:33353943
Molecular Network Profiling in Intestinal- and Diffuse-Type Gastric Cancer. PMID:33353109
Cytoskeletal Control and Wnt Signaling-APC's Dual Contributions in Stem Cell Division and Colorectal Cancer. PMID:33348689
Identification of the Roles of Chromobox Family Members in Gastric Cancer: A Study Based on Multiple Datasets. PMID:33344640
Hypoxia-Associated Prognostic Markers and Competing Endogenous RNA Co-Expression Networks in Breast Cancer. PMID:33344235
Attenuation of SRC Kinase Activity Augments PARP Inhibitor-mediated Synthetic Lethality in BRCA2-altered Prostate Tumors. PMID:33334906
Development of an Immunogenomic Landscape-Based Prognostic Index of Head and Neck Squamous Cell Carcinoma. PMID:33330624
Deficiency of G9a Inhibits Cell Proliferation and Activates Autophagy via Transcriptionally Regulating c-Myc Expression in Glioblastoma. PMID:33330479
GPR115 Contributes to Lung Adenocarcinoma Metastasis Associated With LAMC2 and Predicts a Poor Prognosis. PMID:33330053
Drug Response Associated With and Prognostic lncRNAs Mediated by DNA Methylation and Transcription Factors in Colon Cancer. PMID:33329694
Identification of Mutated Peptides in Bladder Cancer From Exomic Sequencing Data Reveals Negative Correlation Between Mutation-Specific Immunoreactivity and Inflammation. PMID:33329543
Oncology and Pharmacogenomics Insights in Polycystic Ovary Syndrome: An Integrative Analysis. PMID:33329391
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. PMID:33326793
Characterization of the Prognostic Values of the CXCR1-7 in Clear Cell Renal Cell Carcinoma (ccRCC) Microenvironment. PMID:33324682
Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II-practical challenges. PMID:33323463
CDKN2A-Inactivated Pancreatic Ductal Adenocarcinoma Exhibits Therapeutic Sensitivity to Paclitaxel: A Bioinformatics Study. PMID:33322698
Activation of the Ion Channel TRPV4 Induces Epithelial to Mesenchymal Transition in Breast Cancer Cells. PMID:33322037
Prognostic value of intratumoral lymphocyte-to-monocyte ratio and M0 macrophage enrichment in tumor immune microenvironment of melanoma. PMID:33318782
Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations. PMID:33318584
Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity. PMID:33318037
SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies. PMID:33318036
Convergent network effects along the axis of gene expression during prostate cancer progression. PMID:33317623
Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells. PMID:33316932
A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death. PMID:33314700
CCTs as new biomarkers for the prognosis of head and neck squamous cancer. PMID:33313411
Genomic analysis of the prognostic effect of tumor-associated neutrophil-related genes across 15 solid cancer types: an immune perspective. PMID:33313252
Updates on "Cancer Genomics and Epigenomics". PMID:33312884
Comprehensive analysis of the functions and prognostic significance of RNA-binding proteins in bladder urothelial carcinoma. PMID:33312357
Targeted massively parallel sequencing of mature lymphoid neoplasms: assessment of empirical application and diagnostic utility in routine clinical practice. PMID:33311649
Differential genetic mutations of ectoderm, mesoderm, and endoderm-derived tumors in TCGA database. PMID:33308219
SPRED1 deletion confers resistance to MAPK inhibition in melanoma. PMID:33306107
The m6A reader protein YTHDC2 is a potential biomarker and associated with immune infiltration in head and neck squamous cell carcinoma. PMID:33304653
The role of the SWI/SNF chromatin remodeling complex in pancreatic ductal adenocarcinoma. PMID:33301642
BMP signaling is a therapeutic target in ovarian cancer. PMID:33298901
The ZNF750-RAC1 axis as potential prognostic factor for breast cancer. PMID:33298895
Identification of Genes Required for Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells In Vitro. PMID:33298586
Human Papillomavirus 16 (HPV16) E2 Repression of TWIST1 Transcription Is a Potential Mediator of HPV16 Cancer Outcomes. PMID:33298572
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer. PMID:33298139
Multi-Omics Analysis Identifying Key Biomarkers in Ovarian Cancer. PMID:33297760
Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer. PMID:33294279
Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression. PMID:33293694
MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role. PMID:33293474
Recurrent SETD2 mutation in NPM1-mutated acute myeloid leukemia. PMID:33292784
Assessing immune infiltration and the tumor microenvironment for the diagnosis and prognosis of sarcoma. PMID:33292275
ZBTB7A, a potential biomarker for prognosis and immune infiltrates, inhibits progression of endometrial cancer based on bioinformatics analysis and experiments. PMID:33292231
Evaluation of Clinicopathological and Molecular Parameters on Disease Recurrence of Papillary Thyroid Cancer Patient: A Retrospective Observational Study. PMID:33291668
A Novel Four-Gene Score to Predict Pathologically Complete (R0) Resection and Survival in Pancreatic Cancer. PMID:33291601
MSI1 Promotes the Expression of the GBM Stem Cell Marker CD44 by Impairing miRNA-Dependent Degradation. PMID:33291443
KVarPredDB: a database for predicting pathogenicity of missense sequence variants of keratin genes associated with genodermatoses. PMID:33287903
The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma. PMID:33287763
Identification of a four-gene panel predicting overall survival for lung adenocarcinoma. PMID:33287749
Differences in key genes in human alveolar macrophages between phenotypically normal smokers and nonsmokers: diagnostic and prognostic value in lung cancer. PMID:33284895
The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response. PMID:33282964
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer. PMID:33282948
DPM1 expression as a potential prognostic tumor marker in hepatocellular carcinoma. PMID:33282554
β-hydroxybutyrate does not alter the effects of glucose deprivation on breast cancer cells. PMID:33281976
Identification of key genes in lung adenocarcinoma based on a competing endogenous RNA network. PMID:33281971
PARPBP is a prognostic marker and confers anthracycline resistance to breast cancer. PMID:33281951
Immune-Related Gene-Based Novel Subtypes to Establish a Model Predicting the Risk of Prostate Cancer. PMID:33281882
SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence. PMID:33277667
An integrated approach to biomarker discovery reveals gene signatures highly predictive of cancer progression. PMID:33277589
NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis. PMID:33276631
Expression of ATP/GTP Binding Protein 1 Has Prognostic Value for the Clinical Outcomes in Non-Small Cell Lung Carcinoma. PMID:33276627
Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration-resistant prostate cancer. PMID:33275817
A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3. PMID:33273692
Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma. PMID:33272983
Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas. PMID:33271120
Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors. PMID:33270827
G Protein-Coupled receptors and heterotrimeric G proteins as cancer drivers. PMID:33270228
Oncogenic Roles of RAD51AP1 in Tumor Tissues Related to Overall Survival and Disease-Free Survival in Hepatocellular Carcinoma. PMID:33269607
Expression and Bioinformatics-Based Functional Analysis of UAP1 in Lung Adenocarcinoma. PMID:33269005
Multi-Omics Database Analysis of Aminoacyl-tRNA Synthetases in Cancer. PMID:33266490
Construction of a Novel Multigene Panel Potently Predicting Poor Prognosis in Patients with Clear Cell Renal Cell Carcinoma. PMID:33266355
Differential Effects of Cancer-Associated Mutations Enriched in Helix H3 of PPARγ. PMID:33266062
N6-methyladenine-related genes affect biological behavior and the prognosis of glioma. PMID:33264518
Functional characterization of uveal melanoma oncogenes. PMID:33262460
Glycoproteomics-based signatures for tumor subtyping and clinical outcome prediction of high-grade serous ovarian cancer. PMID:33262351
Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease. PMID:33261012
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression. PMID:33257795
LNX1 Modulates Notch1 Signaling to Promote Expansion of the Glioma Stem Cell Population during Temozolomide Therapy in Glioblastoma. PMID:33255632
TET2/IDH1/2/WT1 and NPM1 Mutations Influence the RUNX1 Expression Correlations in Acute Myeloid Leukemia. PMID:33255417
Effective RNA Knockdown Using CRISPR-Cas13a and Molecular Targeting of the EML4-ALK Transcript in H3122 Lung Cancer Cells. PMID:33255340
Targeted Sequencing of Pancreatic Adenocarcinomas from Patients with Metachronous Pulmonary Metastases. PMID:33255265
Identification of potential biomarkers for lung adenocarcinoma. PMID:33251353
A Novel RNA Binding Protein-Related Prognostic Signature for Hepatocellular Carcinoma. PMID:33251144
Multi-Omics Analysis to Characterize Cigarette Smoke Induced Molecular Alterations in Esophageal Cells. PMID:33251127
VarStack: a web tool for data retrieval to interpret somatic variants in cancer. PMID:33247936
c-KIT-ERK1/2 signaling activated ELK1 and upregulated carcinoembryonic antigen expression to promote colorectal cancer progression. PMID:33247506
Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics. PMID:33244070
Lower mutant-allele tumor heterogeneity is a biomarker in FGFR3-mutant bladder cancer for better prognosis. PMID:33243261
Tumor Derived SIGLEC Family Genes May Play Roles in Tumor Genesis, Progression, and Immune Microenvironment Regulation. PMID:33240817
CDK5 Inhibition Abrogates TNBC Stem-Cell Property and Enhances Anti-PD-1 Therapy. PMID:33240752
Bioinformatics Analysis Identifies a Novel Role of GINS1 Gene in Colorectal Cancer. PMID:33235499
Prognostic Value of Gastrokine-2 (GKN2) and Its Correlation with Tumor-Infiltrating Immune Cells in Lung Cancer and Gastric Cancers. PMID:33235482
Bioinformatics for The Prognostic Value and Function of Cubilin (CUBN) in Colorectal Cancer. PMID:33235183
Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. PMID:33232662
Pan-cancer methylation analysis reveals an inverse correlation of tumor immunogenicity with methylation aberrancy. PMID:33230567
Identification of transcription factor co-regulators that drive prostate cancer progression. PMID:33230156
SWI/SNF Alterations in Squamous Bladder Cancers. PMID:33227989
The value of a metabolic reprogramming-related gene signature for pancreatic adenocarcinoma prognosis prediction. PMID:33226369
PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis. PMID:33225610
Clinicopathological and immunological characterization of RNA m6 A methylation regulators in ovarian cancer. PMID:33225598
An Innovative Immune Score-Based Prognostic Nomogram for Patients with Cervical Cancer. PMID:33224983
Cell Plasticity-Related Phenotypes and Taxanes Resistance in Castration-Resistant Prostate Cancer. PMID:33224888
Clinical and molecular distinctions in patients with refractory colon cancer who benefit from regorafenib treatment. PMID:33224274
FGFR3 Alterations in the Era of Immunotherapy for Urothelial Bladder Cancer. PMID:33224141
Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma. PMID:33223751
A novel miRNA inhibits metastasis of prostate cancer via decreasing CREBBP-mediated histone acetylation. PMID:33221996
A Phase II Study of Telisotuzumab Vedotin in Patients With c-MET-positive Stage IV or Recurrent Squamous Cell Lung Cancer (LUNG-MAP Sub-study S1400K, NCT03574753). PMID:33221175
Genetic Mutations and Variants in the Susceptibility of Familial Non-Medullary Thyroid Cancer. PMID:33218058
Genomic Amplification and Functional Dependency of the Gamma Actin Gene ACTG1 in Uterine Cancer. PMID:33217970
MEK inhibitors in non-V600 BRAF mutations and fusions. PMID:33216832
Comprehensive analysis of partial epithelial mesenchymal transition-related genes in hepatocellular carcinoma. PMID:33215860
Frequency and prognostic value of mutations associated with the homologous recombination DNA repair pathway in a large pan cancer cohort. PMID:33214570
Functional role of vitronectin in breast cancer. PMID:33211735
Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA. PMID:33210317
Expression and role of nuclear receptor-interacting protein 1 (NRIP1) in stomach adenocarcinoma. PMID:33209873
A comprehensive pan-cancer study of fibroblast growth factor receptor aberrations in Chinese cancer patients. PMID:33209870
Angiogenesis related gene expression significantly associated with the prognostic role of an urothelial bladder carcinoma. PMID:33209684
Comprehensive analysis of the prognosis for chromobox family in gastric cancer. PMID:33209489
Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality. PMID:33205017
Somatic mutational landscapes of adherens junctions and their functional consequences in cutaneous melanoma development. PMID:33204327
TP53 mutations and CDKN2A mutations/deletions are highly recurrent molecular alterations in the malignant progression of sinonasal papillomas. PMID:33203919
ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL. PMID:33203881
The Expression Profiles of ADME Genes in Human Cancers and Their Associations with Clinical Outcomes. PMID:33202946
Cancer Stem Cells and the Slow Cycling Phenotype: How to Cut the Gordian Knot Driving Resistance to Therapy in Melanoma. PMID:33202944
USP25 Regulates EGFR Fate by Modulating EGF-Induced Ubiquitylation Dynamics. PMID:33202887
Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer. PMID:33199492
EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers. PMID:33199443
E3 Ubiquitin Ligase TRIP12: Regulation, Structure, and Physiopathological Functions. PMID:33198194
Mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon: detailed molecular characterisation of two cases indicates a distinct colorectal cancer entity. PMID:33197299
CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics. PMID:33196823
PAXX, Not NHEJ1 Is an Independent Prognosticator in Colon Cancer. PMID:33195430
Identification of Key Genes in Lung Adenocarcinoma and Establishment of Prognostic Mode. PMID:33195408
Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter? PMID:33194757
Genomic Profiling Comparison of Germline BRCA and Non-BRCA Carriers Reveals CCNE1 Amplification as a Risk Factor for Non-BRCA Carriers in Patients With Triple-Negative Breast Cancer. PMID:33194720
Molecular and Clinical Characterization of a Novel Prognostic and Immunologic Biomarker FAM111A in Diffuse Lower-Grade Glioma. PMID:33194678
Epithelial Splicing Regulatory Protein (ESPR1) Expression in an Unfavorable Prognostic Factor in Prostate Cancer Patients. PMID:33194621
Effects of RNA Binding Proteins on the Prognosis and Malignant Progression in Prostate Cancer. PMID:33193734
Nicotinamide N-Methyltransferase Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric Cancer. PMID:33193702
Integration of Online Omics-Data Resources for Cancer Research. PMID:33193699
Multi-Omics Analysis Detects Novel Prognostic Subgroups of Breast Cancer. PMID:33193681
Theoretical and in silico Analyses Reveal MYC as a Dynamic Network Biomarker in Colon and Rectal Cancer. PMID:33193630
Data mining combined with experiments to validate CEP55 as a prognostic biomarker in colorectal cancer. PMID:33190424
Prognostic roles of metabolic reprogramming-associated genes in patients with hepatocellular carcinoma. PMID:33188160
SLX4IP Promotes Telomere Maintenance in Androgen Receptor-Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization. PMID:33188147
A Targeted Bioinformatics Assessment of Adrenocortical Carcinoma Reveals Prognostic Implications of GABA System Gene Expression. PMID:33187258
CGPE: an integrated online server for Cancer Gene and Pathway Exploration. PMID:33185687
Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq. PMID:33184288
Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival. PMID:33182511
EZH2 is a negative prognostic biomarker associated with immunosuppression in hepatocellular carcinoma. PMID:33180829
Comprehensive bioinformatics analysis of the TP53 signaling pathway in Wilms' tumor. PMID:33178760
Mitotically associated long non-coding RNA is a tumor promoter in anaplastic thyroid cancer. PMID:33178758
Spectrum of Mesenchymal-Epithelial Transition Aberrations and Potential Clinical Implications: Insights From Integrative Pancancer Analysis. PMID:33178590
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer. PMID:33177715
Molecular pathogenesis of breast cancer: impact of miR-99a-5p and miR-99a-3p regulation on oncogenic genes. PMID:33177704
High SEMA4C expression promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal carcinoma. PMID:33177246
PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways. PMID:33177155
A meta-analysis of BRF2 as a prognostic biomarker in invasive breast carcinoma. PMID:33176745
Cold-inducible RNA binding protein promotes breast cancer cell malignancy by regulating Cystatin C levels. PMID:33172965
Clinical and mutational profiles of adult medulloblastoma groups. PMID:33172502
Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions. PMID:33168106
Comprehensive Analysis of the Expression and Prognosis for MCMs in Human Gastric Cancer. PMID:33167799
Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA. PMID:33161228
Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome. PMID:33158447
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. PMID:33157015
Overexpression of Rhophilin Rho GTPase-binding protein 2 promotes hepatocellular carcinoma. PMID:33154780
Taxane-induced Attenuation of the CXCR2/BCL-2 Axis Sensitizes Prostate Cancer to Platinum-based Treatment. PMID:33153817
Characterization of Mutational Status, Spheroid Formation, and Drug Response of a New Genomically-Stable Human Ovarian Clear Cell Carcinoma Cell Line, 105C. PMID:33153119
Differential Expression of PEG10 Contributes to Aggressive Disease in Early Versus Late-Onset Colorectal Cancer. PMID:33149023
Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells. PMID:33148662
Identification of ALDH3A2 as a novel prognostic biomarker in gastric adenocarcinoma using integrated bioinformatics analysis. PMID:33148208
Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations. PMID:33147938
Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment. PMID:33146700
Expression Patterns and Prognostic Values of ORMDL1 in Different Cancers. PMID:33145351
Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion. PMID:33144694
Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients. PMID:33144586
GBAF, a small BAF sub-complex with big implications: a systematic review. PMID:33143733
MYC Targets Scores Are Associated with Cancer Aggressiveness and Poor Survival in ER-Positive Primary and Metastatic Breast Cancer. PMID:33143224
FAM188B Expression Is Critical for Cell Growth via FOXM1 Regulation in Lung Cancer. PMID:33142744
Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer. PMID:33142117
Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47phox. PMID:33139577
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status. PMID:33138032
Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation. PMID:33137094
netboxr: Automated discovery of biological process modules by network analysis in R. PMID:33137091
Characterization of the Tumor Immune Microenvironment Identifies M0 Macrophage-Enriched Cluster as a Poor Prognostic Factor in Hepatocellular Carcinoma. PMID:33136432
TERT promoter mutation associated with multifocal phenotype and poor prognosis in patients with IDH wild-type glioblastoma. PMID:33134923
An integrative multi-omics network-based approach identifies key regulators for breast cancer. PMID:33133424
TIM3 expression on tumor cells predicts response to anti-PD-1 therapy for renal cancer. PMID:33129110
TRIP13 promotes the proliferation and invasion of lung cancer cells via the Wnt signaling pathway and epithelial-mesenchymal transition. PMID:33128167
Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer. PMID:33127913
Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression. PMID:33127842
Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1. PMID:33126816
YAP/TAZ Signalling in Colorectal Cancer: Lessons from Consensus Molecular Subtypes. PMID:33126419
Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia. PMID:33123685
Multiomic Integration of Public Oncology Databases in Bioconductor. PMID:33119407
Increased SNX20 and PD-L1 Levels Can Predict the Clinical Response to PD-1 Inhibitors in Lung Adenocarcinoma. PMID:33116590
TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L. PMID:33115448
USP1 Regulates TAZ Protein Stability Through Ubiquitin Modifications in Breast Cancer. PMID:33114077
Multicenter Comparison of Molecular Tumor Boards in The Netherlands: Definition, Composition, Methods, and Targeted Therapy Recommendations. PMID:33111480
Comprehensive analysis of the expression of SLC30A family genes and prognosis in human gastric cancer. PMID:33110097
Involvement of NEK2 and its interaction with NDC80 and CEP250 in hepatocellular carcinoma. PMID:33109182
Functional and genomic characterization of patient-derived xenograft model to study the adaptation to mTORC1 inhibitor in clear cell renal cell carcinoma. PMID:33107222
MutSignatures: an R package for extraction and analysis of cancer mutational signatures. PMID:33106540
RNA-binding protein DDX3 mediates posttranscriptional regulation of androgen receptor: A mechanism of castration resistance. PMID:33106406
Prognostic Significance of Oxidation Pathway Mutations in Recurrent Laryngeal Squamous Cell Carcinoma. PMID:33105726
MN1 overexpression with varying tumor grade is a promising predictor of survival of glioma patients. PMID:33105486
DEC2 Serves as Potential Tumor Suppressor in Breast Carcinoma. PMID:33101542
Small interfering RNA-mediated knockdown of KRT80 suppresses colorectal cancer proliferation. PMID:33101466
Functional network analysis reveals potential repurposing of β-blocker atenolol for pancreatic cancer therapy. PMID:33098056
TRIM28 is a distinct prognostic biomarker that worsens the tumor immune microenvironment in lung adenocarcinoma. PMID:33091876
Expression profiles and prognostic significance of AFTPH in different tumors. PMID:33090728
Identification of PKP 2/3 as potential biomarkers of ovarian cancer based on bioinformatics and experiments. PMID:33088217
Glutaminase Inhibitors Induce Thiol-Mediated Oxidative Stress and Radiosensitization in Treatment-Resistant Cervical Cancers. PMID:33087507
Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. PMID:33086062
The genomic landscape of metastatic histologic special types of invasive breast cancer. PMID:33083532
JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma. PMID:33083484
Validation and clinical application of a targeted next-generation sequencing gene panel for solid and hematologic malignancies. PMID:33083132
Identification of hub genes and small molecule therapeutic drugs related to breast cancer with comprehensive bioinformatics analysis. PMID:33083112
Bioinformatic analysis of the expression and prognostic value of chromobox family proteins in human breast cancer. PMID:33082469
MLH1 single-nucleotide variant in circulating tumor DNA predicts overall survival of patients with hepatocellular carcinoma. PMID:33082400
Inhibiting insulin and mTOR signaling by afatinib and crizotinib combination fosters broad cytotoxic effects in cutaneous malignant melanoma. PMID:33082316
Common gene signatures and key pathways in hypopharyngeal and esophageal squamous cell carcinoma: Evidence from bioinformatic analysis. PMID:33080677
The impact of ARID1A mutation on molecular characteristics in colorectal cancer. PMID:33080474
TGFBI modulates tumour hypoxia and promotes breast cancer metastasis. PMID:33080107
Cytosolic pH regulates proliferation and tumour growth by promoting expression of cyclin D1. PMID:33077976
Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma. PMID:33077924
Recurrent urothelial carcinoma-like FGFR3 genomic alterations in malignant Brenner tumors of the ovary. PMID:33077920
HIF1α is not a target of 14q deletion in clear cell renal cancer. PMID:33077781
Melanoma Stem Cell-Like Phenotype and Significant Suppression of Immune Response within a Tumor Are Regulated by TRIM28 Protein. PMID:33076560
Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression. PMID:33076392
The prognostic significance of interferon-stimulated gene 15 (ISG15) in invasive breast cancer. PMID:33073304
Angiogenic factor AGGF1 acts as a tumor suppressor by modulating p53 post-transcriptional modifications and stability via MDM2. PMID:33069768
Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity. PMID:33067454
CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer. PMID:33066224
Identification of ATP8B1 as a Tumor Suppressor Gene for Colorectal Cancer and Its Involvement in Phospholipid Homeostasis. PMID:33062669
Association Between Succinate Receptor SUCNR1 Expression and Immune Infiltrates in Ovarian Cancer. PMID:33062639
The role of m6A-related genes in the prognosis and immune microenvironment of pancreatic adenocarcinoma. PMID:33062408
Comprehensive Analysis of Immunoinhibitors Identifies LGALS9 and TGFBR1 as Potential Prognostic Biomarkers for Pancreatic Cancer. PMID:33062039
Novel sequential treatment with palbociclib enhances the effect of cisplatin in RB-proficient triple-negative breast cancer. PMID:33061853
E2F1/2/7/8 as independent indicators of survival in patients with cervical squamous cell carcinoma. PMID:33061852
Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patients. PMID:33061814
Identification and characterization of functional long noncoding RNAs in cancer. PMID:33058262
Clinical characteristics and prognostic implications of BRCA-associated tumors in males: a pan-tumor survey. PMID:33054725
Comprehensive Exome Analysis of Immunocompetent Metastatic Head and Neck Cancer Models Reveals Patient Relevant Landscapes. PMID:33053752
In silico investigation of heparanase-correlated genes in breast cancer subtypes. PMID:33053017
Characterization of the expression and prognostic value of 14-3-3 isoforms in breast cancer. PMID:33052135
Genotype-Phenotype Features of Germline Variants of the TMEM127 Pheochromocytoma Susceptibility Gene: A 10-Year Update. PMID:33051659
Clinicopathologic significance of protein lysine methyltransferases in cancer. PMID:33050946
Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells. PMID:33050631
A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC. PMID:33049034
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD). PMID:33046988
Loss of ACSM3 confers worsened prognosis and immune exclusion to cutaneous melanoma. PMID:33046979
Transcriptome-Based Network Analysis Unveils Eight Immune-Related Genes as Molecular Signatures in the Immunomodulatory Subtype of Triple-Negative Breast Cancer. PMID:33042828
Deubiquitinase PSMD7 regulates cell fate and is associated with disease progression in breast cancer. PMID:33042429
Identification of KIF23 as a prognostic signature for ovarian cancer based on large-scale sampling and clinical validation. PMID:33042400
Comprehensive characterization of functional eRNAs in lung adenocarcinoma reveals novel regulators and a prognosis-related molecular subtype. PMID:33042282
Development and interpretation of a pathomics-based model for the prediction of microsatellite instability in Colorectal Cancer. PMID:33042271
Association between copy-number alteration of +20q, -14q and -18p and cross-sensitivity to tyrosine kinase inhibitors in clear-cell renal cell carcinoma. PMID:33041663
Inhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer. PMID:33041328
CUP-AI-Dx: A tool for inferring cancer tissue of origin and molecular subtype using RNA gene-expression data and artificial intelligence. PMID:33039710
Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression. PMID:33039351
Spliceosomal factor mutations and mis-splicing in MDS. PMID:33038983
Allele-Specific Role of ERBB2 in the Oncogenic Function of EGFR L861Q in EGFR-Mutant Lung Cancers. PMID:33038514
Bioinformatic Identification of Potential Hub Genes in Muscle-Invasive Bladder Urothelial Carcinoma. PMID:33035117
Identification of a new pseudogenes/lncRNAs-hsa-miR-26b-5p-COL12A1 competing endogenous RNA network associated with prognosis of pancreatic cancer using bioinformatics analysis. PMID:33027767
ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells. PMID:33024871
TOP2A and CENPF are synergistic master regulators activated in cervical cancer. PMID:33023625
Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure. PMID:33020667
Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. PMID:33020180
Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors. PMID:33016929
Comprehensive Analysis of Prognostic Value and Immune Infiltration of Chromobox Family Members in Colorectal Cancer. PMID:33014884
Discoidin Domain Receptors in Melanoma: Potential Therapeutic Targets to Overcome MAPK Inhibitor Resistance. PMID:33014862
Identification of PLOD Family Genes as Novel Prognostic Biomarkers for Hepatocellular Carcinoma. PMID:33014843
Serpin peptidase inhibitor clade A member 1-overexpression in gastric cancer promotes tumor progression in vitro and is associated with poor prognosis. PMID:33014156
Additional genetic alterations in BRAF-mutant gliomas correlate with histologic diagnoses. PMID:33009979
Biopathological Significance of PIWI-piRNA Pathway Deregulation in Invasive Breast Carcinomas. PMID:33008024
Transcriptome Profiling Reveals New Insights into the Immune Microenvironment and Upregulation of Novel Biomarkers in Metastatic Uveal Melanoma. PMID:33008022
MicroRNA-31 Regulates Expression of Wntless in Both Drosophila melanogaster and Human Oral Cancer Cells. PMID:33007980
Inflammatory Breast Cancer: Clinical Implications of Genomic Alterations and Mutational Profiling. PMID:33007869
Secretion of pro-oncogenic AGR2 protein in cancer. PMID:33005802
Regulating Methylation at H3K27: A Trick or Treat for Cancer Cell Plasticity. PMID:33003334
Recurrent ZNF83-E293V Mutation Promotes Bladder Cancer Progression through the NF-κB Pathway via Transcriptional Dysregulation of S100A8. PMID:33002420
Role of serine 365 in BRAF V600E sensitivity to RAF inhibition. PMID:33000894
Upregulation of centromere protein M promotes tumorigenesis: A potential predictive target for cancer in humans. PMID:33000180
Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer. PMID:32999000
PRINS lncRNA Is a New Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas. PMID:32998396
Omics-Based Platforms: Current Status and Potential Use for Cholangiocarcinoma. PMID:32998289
Two Sides of the Same Coin: The Roles of KLF6 in Physiology and Pathophysiology. PMID:32998281
Reconstruction of lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveals functional lncRNAs in skin cutaneous melanoma. PMID:32993558
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway. PMID:32990596
Loss of UTX/KDM6A and the activation of FGFR3 converge to regulate differentiation gene-expression programs in bladder cancer. PMID:32989154
Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer. PMID:32988402
8p11.23 Amplification in Breast Cancer: Molecular Characteristics, Prognosis and Targeted Therapy. PMID:32987805
Integrative Bioinformatics Analysis Reveals Potential Target Genes and TNFα Signaling Inhibition by Brazilin in Metastatic Breast Cancer Cells. PMID:32986377
YTHDF2 correlates with tumor immune infiltrates in lower-grade glioma. PMID:32986017
Genomic Profiling Identified ERCC2 E606Q Mutation in Helicase Domain Respond to Platinum-Based Neoadjuvant Therapy in Urothelial Bladder Cancer. PMID:32984035
Complement C7 (C7), a Potential Tumor Suppressor, Is an Immune-Related Prognostic Biomarker in Prostate Cancer (PC). PMID:32984006
Favorable Immune Microenvironment in Patients with EGFR and MAPK Co-Mutations. PMID:32982525
Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C. PMID:32980867
Overexpression of wild type or a Q311E mutant MB21D2 promotes a pro-oncogenic phenotype in HNSCC. PMID:32979859
EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer. PMID:32978523
Intrahepatic cholangiocarcinomas with IDH1/2 mutation-associated hypermethylation at selective genes and their clinicopathological features. PMID:32978444
A single-cell survey of cellular hierarchy in acute myeloid leukemia. PMID:32977829
Transcriptomics-Based Drug Repurposing Approach Identifies Novel Drugs against Sorafenib-Resistant Hepatocellular Carcinoma. PMID:32977582
Mutational Landscape of Esophageal Squamous Cell Carcinoma in an Indian Cohort. PMID:32974170
Systemic Expression Analysis Reveals Prognostic Significance of WIPI3 in Hepatocellular Carcinoma. PMID:32973867
Prognostic landscape of tumor-infiltrating immune cells and immune-related genes in the tumor microenvironment of gastric cancer. PMID:32969836
USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress. PMID:32968046
Identification of the DNA Replication Regulator MCM Complex Expression and Prognostic Significance in Hepatic Carcinoma. PMID:32964028
Targeting protein tyrosine kinase 6 in cancer. PMID:32956764
Analysis, identification and visualization of subgroups in genomics. PMID:32954413
Novel Potential Therapeutic Target for E2F1 and Prognostic Factors of E2F1/2/3/5/7/8 in Human Gastric Cancer. PMID:32953933
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome. PMID:32953737
Gene Signatures and Prognostic Values of m6A RNA Methylation Regulators in Ovarian Cancer. PMID:32951457
Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma. PMID:32951278
Association of PD-L1 and IDO1 expression with JAK-STAT pathway activation in soft-tissue leiomyosarcoma. PMID:32951108
Bioinformatics Data Mining Repurposes the JAK2 (Janus Kinase 2) Inhibitor Fedratinib for Treating Pancreatic Ductal Adenocarcinoma by Reversing the KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog)-Driven Gene Signature. PMID:32947833
Apolipoprotein C2 - CD36 Promotes Leukemia Growth and Presents a Targetable Axis in Acute Myeloid Leukemia. PMID:32944714
Expression signature, prognosis value, and immune characteristics of Siglec-15 identified by pan-cancer analysis. PMID:32939323
Role of GATA3 exon 6 germline mutations in breast cancer progression in Egyptian female patients. PMID:32938228
Down syndrome iPSC model: endothelial perspective on tumor development. PMID:32934781
Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis. PMID:32932846
The clinical value and potential molecular mechanism of the downregulation of MAOA in hepatocellular carcinoma tissues. PMID:32931665
Distinct cell-types in the prostate share an aging signature suggestive of metabolic reprogramming. PMID:32929410
Genome and transcriptome profiling of FBXW family in human prostate cancer. PMID:32929407
Identification of glycogene-type and validation of ST3GAL6 as a biomarker predicts clinical outcome and cancer cell invasion in urinary bladder cancer. PMID:32929335
Histopathological imaging features- versus molecular measurements-based cancer prognosis modeling. PMID:32929170
Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney. PMID:32928875
BRD4/8/9 are prognostic biomarkers and associated with immune infiltrates in hepatocellular carcinoma. PMID:32927435
HLA Class I Binding of Mutant EGFR Peptides in NSCLC Is Associated With Improved Survival. PMID:32927123
TENET 2.0: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma. PMID:32925947
METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth. PMID:32923617
Small extracellular vesicles modulated by αVβ3 integrin induce neuroendocrine differentiation in recipient cancer cells. PMID:32922691
Potential mechanism of RRM2 for promoting Cervical Cancer based on weighted gene co-expression network analysis. PMID:32922202
Using The Cancer Genome Atlas data to refine the 8th edition of the American Joint Committee on Cancer staging for papillary thyroid carcinoma. PMID:32915437
Male patients with TERT mutation may be more likely to benefit from immunotherapy, especially for melanoma. PMID:32915164
Mutational Landscape in Resected Periampullary Adenocarcinoma: Relationship With Morphology and Clinical Outcome. PMID:32914025
Genomic Analysis of Metastatic Solid Tumors in Veterans: Findings From the VHA National Precision Oncology Program. PMID:32914016
Implementation and Clinical Utility of an Integrated Academic-Community Regional Molecular Tumor Board. PMID:32913980
Zinc finger and BTB domain-containing 7C (ZBTB7C) expression as an independent prognostic factor for colorectal cancer and its relevant molecular mechanisms. PMID:32913494
GMIEC: a shiny application for the identification of gene-targeted drugs for precision medicine. PMID:32912170
The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs. PMID:32911332
SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells. PMID:32909943
Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns. PMID:32907621
CCAAT/Enhancer-Binding Protein Delta (C/EBPδ): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells. PMID:32906832
Transcriptomic and functional pathway features were associated with survival after pathological complete response to neoadjuvant chemotherapy in breast cancer. PMID:32905537
The m6A readers YTHDF1 and YTHDF3 aberrations associated with metastasis and predict poor prognosis in breast cancer patients. PMID:32905518
Integrative Analysis of the IQ Motif-Containing GTPase-Activating Protein Family Indicates That the IQGAP3-PIK3C2B Axis Promotes Invasion in Colon Cancer. PMID:32903879
Rho GDP-Dissociation Inhibitor 2 Inhibits C-X-C Chemokine Receptor Type 4-Mediated Acute Lymphoblastic Leukemia Cell Migration. PMID:32903764
Artificial Intelligence to Decode Cancer Mechanism: Beyond Patient Stratification for Precision Oncology. PMID:32903628
Development of an IFNγ response-related signature for predicting the survival of cutaneous melanoma. PMID:32902917
High expression of UNC5B enhances tumor proliferation, increases metastasis, and worsens prognosis in breast cancer. PMID:32902412
CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes. PMID:32900797
Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma. PMID:32899449
RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling. PMID:32899426
Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression. PMID:32895052
Genomic Profiling Aids Classification of Diagnostically Challenging Uterine Mesenchymal Tumors With Myomelanocytic Differentiation. PMID:32889887
H2A Histone Family Member X (H2AX) Is Upregulated in Ovarian Cancer and Demonstrates Utility as a Prognostic Biomarker in Terms of Overall Survival. PMID:32887437
5-Fluorouracil Conversion Pathway Mutations in Gastric Cancer. PMID:32887417
CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus-Associated Head and Neck Cancers. PMID:32883697
Genomics and Functional Genomics of Malignant Pleural Mesothelioma. PMID:32882916
Critical Role for Cold Shock Protein YB-1 in Cytokinesis. PMID:32882852
Sestrin2 Expression Has Regulatory Properties and Prognostic Value in Lung Cancer. PMID:32882793
Prognostic significance of ARL9 and its methylation in low-grade glioma. PMID:32882327
Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development in the Drosophila larval brain. PMID:32878945
Most Commonly Mutated Genes in High-Grade Serous Ovarian Carcinoma Are Nonessential for Ovarian Surface Epithelial Stem Cell Transformation. PMID:32877668
Genomic subtypes may predict the risk of central nervous system recurrence in diffuse large B-cell lymphoma. PMID:32877514
KAT6A amplifications are associated with shorter progression-free survival and overall survival in patients with endometrial serous carcinoma. PMID:32877461
Identification of potential biomarkers and candidate small molecule drugs in glioblastoma. PMID:32874133
Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway. PMID:32874132
Immortalization of human primary prostate epithelial cells via CRISPR inactivation of the CDKN2A locus and expression of telomerase. PMID:32873916
Comprehensive profiling of immune-related genes in soft tissue sarcoma patients. PMID:32873319
The HMGB1-2 Ovarian Cancer Interactome. The Role of HMGB Proteins and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and Drug-Response. PMID:32867128
Roles for MDC1 in cancer development and treatment. PMID:32866776
Transcriptional and immunohistological assessment of immune infiltration in pancreatic cancer. PMID:32866185
Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets. PMID:32863893
CDK1, CCNB1, and CCNB2 are Prognostic Biomarkers and Correlated with Immune Infiltration in Hepatocellular Carcinoma. PMID:32863381
27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression. PMID:32861706
Identification of Therapeutic and Prognostic Biomarkers of Lamin C (LAMC) Family Members in Head and Neck Squamous Cell Carcinoma. PMID:32860673
Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells. PMID:32859993
Impact of genetic alterations on outcomes of patients with stage I nonsmall cell lung cancer: An analysis of the cancer genome atlas data. PMID:32857918
Germline DNMT3A mutation in familial acute myeloid leukaemia. PMID:32856987
DLBCL with amplification of JAK2/PD-L2 exhibits PMBCL-like CNA pattern and worse clinical outcome resembling those with MYD88 L265P mutation. PMID:32854650
Detection of Germline Mutations in a Cohort of 139 Patients with Bilateral Breast Cancer by Multi-Gene Panel Testing: Impact of Pathogenic Variants in Other Genes beyond BRCA1/2. PMID:32854451
MNX1 Promotes Malignant Progression of Cervical Cancer via Repressing the Transcription of p21cip1. PMID:32850410
Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Pathways Associated With Clinical Outcome in Hepatocellular Carcinoma. PMID:32849813
Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers. PMID:32847042
Association of MUC16 Mutation With Response to Immune Checkpoint Inhibitors in Solid Tumors. PMID:32845327
A robust 11-genes prognostic model can predict overall survival in bladder cancer patients based on five cohorts. PMID:32843852
Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma. PMID:32843721
Endometrial Cancer as a Metabolic Disease with Dysregulated PI3K Signaling: Shedding Light on Novel Therapeutic Strategies. PMID:32842547
Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate. PMID:32839463
DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas. PMID:32838940
Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain. PMID:32838755
Protein kinase A inhibitor proteins (PKIs) divert GPCR-Gαs-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth. PMID:32830375
Expression Profile and Prognostic Values of Mini-Chromosome Maintenance Families (MCMs) in Breast Cancer. PMID:32830194
ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3. PMID:32826950
OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity. PMID:32826889
Neoadjuvant metformin added to conventional chemotherapy synergizes anti-proliferative effects in ovarian cancer. PMID:32825834
Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications. PMID:32825279
Role of Adipose Tissue-Derived Autotaxin, Lysophosphatidate Signaling, and Inflammation in the Progression and Treatment of Breast Cancer. PMID:32824846
The Oncogenic Roles of PTTG1 and PTTG2 Genes and Pseudogene PTTG3P in Head and Neck Squamous Cell Carcinomas. PMID:32824814
Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3. PMID:32824461
Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer. PMID:32824360
Clonal Hematopoiesis in Liquid Biopsy: From Biological Noise to Valuable Clinical Implications. PMID:32823942
Cyclin E2 Promotes Whole Genome Doubling in Breast Cancer. PMID:32823571
Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing. PMID:32822576
Hippo/MST blocks breast cancer by downregulating WBP2 oncogene expression via miRNA processor Dicer. PMID:32820148
Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression. PMID:32820145
Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite. PMID:32820045
Down-regulation of tenascin-C inhibits breast cancer cells development by cell growth, migration, and adhesion impairment. PMID:32817625
A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers. PMID:32817551
The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype. PMID:32817494
SUMOylation of E2F1 Regulates Expression of EZH2. PMID:32816857
TERT mutations correlate with higher TMB value and unique tumor microenvironment and may be a potential biomarker for anti-CTLA4 treatment. PMID:32810393
Deficiency of pseudogene UPAT leads to hepatocellular carcinoma progression and forms a positive feedback loop with ZEB1. PMID:32808348
FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity. PMID:32807875
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints. PMID:32807787
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice. PMID:32807776
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy. PMID:32807225
Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer. PMID:32807223
1-Chromonyl-5-Imidazolylpentadienone Demonstrates Anti-Cancer Action against TNBC and Exhibits Synergism with Paclitaxel. PMID:32806551
Downstream neighbor of SON (DONSON) is associated with unfavorable survival across diverse cancers with oncogenic properties in clear cell renal cell carcinoma. PMID:32805676
Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma. PMID:32801999
Analyses of DNA Methylation Involved in the Activation of Nuclear Karyopherin Alpha 2 Leading to Identify the Progression and Prognostic Significance Across Human Breast Cancer. PMID:32801900
Low Expression of APOB mRNA or Its Hypermethylation Predicts Favorable Overall Survival in Patients with Low-Grade Glioma. PMID:32801753
Prognostic value of S1PR1 and its correlation with immune infiltrates in breast and lung cancers. PMID:32799825
Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1. PMID:32796628
Expression of p42.3 in non-small cell lung cancer. PMID:32793664
Aberrant pregnancy-associated plasma protein-A expression in breast cancers prognosticates clinical outcomes. PMID:32792532
Subunits of ARID1 serve as novel biomarkers for the sensitivity to immune checkpoint inhibitors and prognosis of advanced non-small cell lung cancer. PMID:32791957
PARP Inhibitors and Prostate Cancer: To Infinity and Beyond BRCA. PMID:32790034
Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide. PMID:32785847
Design and Testing of a Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA. PMID:32785074
Notch Transduction in Non-Small Cell Lung Cancer. PMID:32784481
High expression of EMP1 predicts a poor prognosis and correlates with immune infiltrates in bladder urothelial carcinoma. PMID:32782602
miR129-1 regulates protein phosphatase 1D protein expression under hypoxic conditions in non-small cell lung cancer cells harboring a TP53 mutation. PMID:32782541
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. PMID:32782249
Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer. PMID:32781581
NRF2 Dysregulation in Hepatocellular Carcinoma and Ischemia: A Cohort Study and Laboratory Investigation. PMID:32780006
Expanding cancer predisposition genes with ultra-rare cancer-exclusive human variations. PMID:32778766
Prognostic value and therapeutic implications of ZHX family member expression in human gastric cancer. PMID:32774706
Somatic mutations in genes associated with mismatch repair predict survival in patients with metastatic cancer receiving immune checkpoint inhibitors. PMID:32774500
Identification of CD38 as a potential biomarker in skin cutaneous melanoma using bioinformatics analysis. PMID:32774485
Integrated genetic and epigenetic analysis of cancer-related genes in non-ampullary duodenal adenomas and intramucosal adenocarcinomas. PMID:32770675
Genetic heterogeneity and prognostic impact of recurrent ANK2 and TP53 mutations in mantle cell lymphoma: a multi-centre cohort study. PMID:32770099
Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis. PMID:32768595
A phase 2 trial of buparlisib in patients with platinum-resistant metastatic urothelial carcinoma. PMID:32767682
The molecular functions of RIT1 and its contribution to human disease. PMID:32766847
Bioinformatics analysis shows that TOP2A functions as a key candidate gene in the progression of cervical cancer. PMID:32765860
Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer. PMID:32765584
Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence. PMID:32764696
iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome. PMID:32764607
The Impact of Coilin Nonsynonymous SNP Variants E121K and V145I on Cell Growth and Cajal Body Formation: The First Characterization. PMID:32764415
Alternative splicing reverses the cell-intrinsic and cell-extrinsic pro-oncogenic potentials of YAP1. PMID:32763976
The identification of six risk genes for ovarian cancer platinum response based on global network algorithm and verification analysis. PMID:32762026
High frequency of exon 20 S768I EGFR mutation detected in malignant pleural effusions: A poor prognosticator of NSCLC. PMID:32761886
Abnormal expression and prognostic significance of EPB41L1 in kidney renal clear cell carcinoma based on data mining. PMID:32760223
ROS1-dependent cancers - biology, diagnostics and therapeutics. PMID:32760015
Comprehensive Analysis of Expression, Clinicopathological Association and Potential Prognostic Significance of RABs in Pancreatic Cancer. PMID:32759795
The Role of Steroid Hormone Receptors in Urothelial Tumorigenesis. PMID:32759680
The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency. PMID:32755579
The Dysregulation and Prognostic Analysis of STRIPAK Complex Across Cancers. PMID:32754603
PLEKHS1 Over-Expression is Associated with Metastases and Poor Outcomes in Papillary Thyroid Carcinoma. PMID:32752127
Genomic Database Analysis of Uterine Leiomyosarcoma Mutational Profile. PMID:32751892
Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy. PMID:32751840
Oncogenic Serine 45-Deleted β-Catenin Remains Susceptible to Wnt Stimulation and APC Regulation in Human Colonocytes. PMID:32751567
Metastasis of Uveal Melanoma with Monosomy-3 Is Associated with a Less Glycogenetic Gene Expression Profile and the Dysregulation of Glycogen Storage. PMID:32751097
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer. PMID:32749453
Molecular profiling of immune cell-enriched Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) interacting protein USP13. PMID:32735883
DNA Methylation: A Potential Biomarker of Chronic Obstructive Pulmonary Disease. PMID:32733890
Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma. PMID:32733646
Comprehensive Cohort Analysis of Mutational Spectrum in Early Onset Breast Cancer Patients. PMID:32731431
A Prognostic Nomogram Based on Immune Scores Predicts Postoperative Survival for Patients with Hepatocellular Carcinoma. PMID:32724794
Genomic analysis of biomarkers related to the prognosis of acute myeloid leukemia. PMID:32724426
Identification of hub genes involved in the occurrence and development of hepatocellular carcinoma via bioinformatics analysis. PMID:32724412
Mining the prognostic significance of the GINS2 gene in human breast cancer using bioinformatics analysis. PMID:32724372
PD-L1 expression increased by IFN-γ via JAK2-STAT1 signaling and predicts a poor survival in colorectal cancer. PMID:32724352
PARP Inhibitor Resistance Mechanisms and Implications for Post-Progression Combination Therapies. PMID:32722408
Pan-Cancer Analysis of the Genomic Alterations and Mutations of the Matrisome. PMID:32722287
Comprehensive Genomic Analysis Reveals the Prognostic Role of LRRK2 Copy-Number Variations in Human Malignancies. PMID:32722212
Transcriptomic Profile of Lymphovascular Invasion, a Known Risk Factor of Pancreatic Ductal Adenocarcinoma Metastasis. PMID:32722116
Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. PMID:32721948
Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal adenocarcinoma. PMID:32719550
Cancer-Testis Gene Expression in Hepatocellular Carcinoma: Identification of Prognostic Markers and Potential Targets for Immunotherapy. PMID:32715976
Characterisation of Ovarian Cancer Cell Line NIH-OVCAR3 and Implications of Genomic, Transcriptomic, Proteomic and Functional DNA Damage Response Biomarkers for Therapeutic Targeting. PMID:32709004
TCGA Pan-Cancer Genomic Analysis of Alternative Lengthening of Telomeres (ALT) Related Genes. PMID:32708340
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer. PMID:32708015
Chemically Induced Hypoxia Enhances miRNA Functions in Breast Cancer. PMID:32707933
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution. PMID:32707077
Enabling Agile Clinical and Translational Data Warehousing: Platform Development and Evaluation. PMID:32706673
FAK inhibition radiosensitizes pancreatic ductal adenocarcinoma cells in vitro. PMID:32705304
Identifying the novel key genes in renal cell carcinoma by bioinformatics analysis and cell experiments. PMID:32699530
Establishment of the prognostic index of lung squamous cell carcinoma based on immunogenomic landscape analysis. PMID:32699529
Inactivating mutations in genes encoding for components of the BAF/PBAF complex and immune-checkpoint inhibitor outcome. PMID:32695398
SFRP1 increases TMPRSS2-ERG expression promoting neoplastic features in prostate cancer in vitro and in vivo. PMID:32694934
Identifying strategies to target the metabolic flexibility of tumours. PMID:32694609
Increased nuclear factor I/B expression in prostate cancer correlates with AR expression. PMID:32692871
BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency. PMID:32690724
Comprehensive analysis of the expression of sodium/potassium-ATPase α subunits and prognosis of ovarian serous cystadenocarcinoma. PMID:32684846
Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer. PMID:32684626
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer. PMID:32679108
TGFβ2-mediated epithelial-mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance. PMID:32678313
Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer. PMID:32678307
Class IA PI3K regulatory subunits: p110-independent roles and structures. PMID:32677674
Radiomics Features Predict CIC Mutation Status in Lower Grade Glioma. PMID:32676453
Prostate cancer biology & genomics. PMID:32676435
PODXL2 maintains cellular stemness and promotes breast cancer development through the Rac1/Akt pathway. PMID:32669966
The prognostic value and potential mechanism of Matrix Metalloproteinases among Prostate Cancer. PMID:32669958
Disparate survival of late-stage male oropharyngeal cancer in Appalachia. PMID:32669588
CCR2 of Tumor Microenvironmental Cells Is a Relevant Modulator of Glioma Biology. PMID:32668709
The roles of histone variants in fine-tuning chromatin organization and function. PMID:32665685
ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader-Follower Relationship That Drives Collective Invasion. PMID:32661136
High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients. PMID:32658903
Analysis of deubiquitinase OTUD5 as a biomarker and therapeutic target for cervical cancer by bioinformatic analysis. PMID:32655987
A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma. PMID:32651364
Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency. PMID:32651270
The E2F Pathway Score as a Predictive Biomarker of Response to Neoadjuvant Therapy in ER+/HER2- Breast Cancer. PMID:32650578
Cell Lineage-Based Stratification for Glioblastoma. PMID:32649888
The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer. PMID:32649682
Novel monoclonal antibody against integrin α3 shows therapeutic potential for ovarian cancer. PMID:32648337
Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells. PMID:32647287
Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution. PMID:32647202
SLC7A2 serves as a potential biomarker and therapeutic target for ovarian cancer. PMID:32647070
Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis. PMID:32640634
Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene. PMID:32639993
Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade. PMID:32639068
Characterization of TNNC1 as a Novel Tumor Suppressor of Lung Adenocarcinoma. PMID:32638704
Synergistic effects of pazopanib and hyperthermia against uterine leiomyosarcoma growth mediated by downregulation of histone acetyltransferase 1. PMID:32638047
Bioinformatics analysis of high-throughput data to validate potential novel biomarkers and small molecule drugs for glioblastoma multiforme. PMID:32634050
Novel prognostic prediction model constructed through machine learning on the basis of methylation-driven genes in kidney renal clear cell carcinoma. PMID:32633782
Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer. PMID:32631905
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling. PMID:32630372
L1CAM, CA9, KLK6, HPN, and ALDH1A1 as Potential Serum Markers in Primary and Metastatic Colorectal Cancer Screening. PMID:32630086
Contribution of Immune Cells to Glucocorticoid Receptor Expression in Breast Cancer. PMID:32629782
Big data-based identification of methylated genes associated with drug resistance and prognosis in ovarian cancer. PMID:32629664
Application of cAMP-dependent catalytic subunit β (PRKACB) Low Expression in Predicting Worse Overall Survival: A Potential Therapeutic Target for Colorectal Carcinoma. PMID:32626531
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target. PMID:32620742
Radiomic analysis identifies tumor subtypes associated with distinct molecular and microenvironmental factors in head and neck squamous cell carcinoma. PMID:32619927
A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue. PMID:32619021
The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer. PMID:32612943
Evaluation of Gene Expression Data From Cybrids and Tumours Highlights Elevated NDRG1-Driven Proliferation in Triple-Negative Breast Cancer. PMID:32612361
A novel molecular-clinicopathologic nomogram to improve prognosis prediction of hepatocellular carcinoma. PMID:32611831
miRNA Clusters with Down-Regulated Expression in Human Colorectal Cancer and Their Regulation. PMID:32610706
KIT and Melanoma: Biological Insights and Clinical Implications. PMID:32608199
ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells. PMID:32606936
Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes. PMID:32605315
Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer. PMID:32603375
Genetic relationship between Hashimoto`s thyroiditis and papillary thyroid carcinoma with coexisting Hashimoto`s thyroiditis. PMID:32603365
Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection. PMID:32602627
Tumor Immune Microenvironment Clusters in Localized Prostate Adenocarcinoma: Prognostic Impact of Macrophage Enriched/Plasma Cell Non-Enriched Subtypes. PMID:32599760
Elevated expression of minichromosome maintenance 3 indicates poor outcomes and promotes G1/S cell cycle progression, proliferation, migration and invasion in colorectal cancer. PMID:32597491
miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway. PMID:32596290
The Role of RNA Splicing Factors in Cancer: Regulation of Viral and Human Gene Expression in Human Papillomavirus-Related Cervical Cancer. PMID:32596243
Identification of prognostic risk factors for pancreatic cancer using bioinformatics analysis. PMID:32587798
Systematic Analysis of Spleen Tyrosine Kinase Expression and its Clinical Outcomes in Various Cancers. PMID:32587490
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development. PMID:32579928
The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development. PMID:32576626
Using Pharmacology to Squeeze the Life Out of Childhood Leukemia, and Potential Strategies to Achieve Breakthroughs in Medulloblastoma Treatment. PMID:32571983
Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells. PMID:32571254
ZEB1/miR-200c/AGR2: A New Regulatory Loop Modulating the Epithelial-Mesenchymal Transition in Lung Adenocarcinomas. PMID:32570918
AML chemoresistance: The role of mutant TP53 subclonal expansion and therapy strategy. PMID:32569759
Alzheimer Gene BIN1 may Simultaneously Influence Dementia Risk and Androgen Deprivation Therapy Dosage in Prostate Cancer. PMID:32568785
Prevalence of disease-causing genes in Japanese patients with BRCA1/2-wildtype hereditary breast and ovarian cancer syndrome. PMID:32566746
Identification of a Robust Five-Gene Risk Model in Prostate Cancer: A Robust Likelihood-Based Survival Analysis. PMID:32566639
FOXP3 promotes colorectal carcinoma liver metastases by evaluating MMP9 expression via regulating S-adenosylmethionine metabolism. PMID:32566619
Bioinformatics analysis of prognosis-related long non-coding RNAs in invasive breast carcinoma. PMID:32565939
FAM83H and SCRIB stabilize β-catenin and stimulate progression of gastric carcinoma. PMID:32564009
The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways. PMID:32561656
Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress. PMID:32559414
Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium. PMID:32555365
Association of molecular characteristics with survival in advanced non-small cell lung cancer patients treated with checkpoint inhibitors. PMID:32554069
Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer. PMID:32552862
Ubiquilin Networking in Cancers. PMID:32549375
Identification of Early Warning Signals at the Critical Transition Point of Colorectal Cancer Based on Dynamic Network Analysis. PMID:32548109
Big Data-Based Identification of Multi-Gene Prognostic Signatures in Liver Cancer. PMID:32547951
MicroRNA-17-5p regulates EMT by targeting vimentin in colorectal cancer. PMID:32546833
Cotargeting of XPO1 Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Acute Myeloid Leukemia. PMID:32545904
Neutrophil Extracellular Traps (NETs) Promote Pro-Metastatic Phenotype in Human Breast Cancer Cells through Epithelial-Mesenchymal Transition. PMID:32545405
(-)-Oleocanthal as a Dual c-MET-COX2 Inhibitor for the Control of Lung Cancer. PMID:32545325
The novel lncRNA PTTG3P is downregulated and predicts poor prognosis in non-small cell lung cancer. PMID:32542097
Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia. PMID:32541670
DNA methylation-based diagnostic and prognostic biomarkers of nasopharyngeal carcinoma patients. PMID:32541515
HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma. PMID:32540961
Molecular Landscape of BRAF-Mutant NSCLC Reveals an Association Between Clonality and Driver Mutations and Identifies Targetable Non-V600 Driver Mutations. PMID:32540409
Identification of genes associated with gastric cancer survival and construction of a nomogram to improve risk stratification for patients with gastric cancer. PMID:32537023
UBE2I promotes metastasis and correlates with poor prognosis in hepatocellular carcinoma. PMID:32536822
Deep learning-based classification and mutation prediction from histopathological images of hepatocellular carcinoma. PMID:32536036
Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator. PMID:32533515
Mediator complex subunit 16 is down-regulated in papillary thyroid cancer, leading to increased transforming growth factor-β signaling and radioiodine resistance. PMID:32532820
Update on GNA Alterations in Cancer: Implications for Uveal Melanoma Treatment. PMID:32532044
Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells. PMID:32528731
Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 in Drosophila. PMID:32527935
Tissue- and development-stage-specific mRNA and heterogeneous CNV signatures of human ribosomal proteins in normal and cancer samples. PMID:32525984
Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells. PMID:32525891
Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer. PMID:32521267
Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen. PMID:32518267
Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein. PMID:32518090
Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression. PMID:32517178
Long Non-Coding RNA HAND2-AS1 Acts as a Tumor Suppressor in High-Grade Serous Ovarian Carcinoma. PMID:32517089
Selective Translation of Cell Fate Regulators Mediates Tolerance to Broad Oncogenic Stress. PMID:32516567
A robust twelve-gene signature for prognosis prediction of hepatocellular carcinoma. PMID:32514252
Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa. PMID:32514162
MET-dependent solid tumours - molecular diagnosis and targeted therapy. PMID:32514147
Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma. PMID:32513387
An Overview of Candidate Therapeutic Target Genes in Ovarian Cancer. PMID:32512900
Omics Integration Analyses Reveal the Early Evolution of Malignancy in Breast Cancer. PMID:32512721
ProTrack: An Interactive Multi-Omics Data Browser for Proteogenomic Studies. PMID:32510176
Mining the Prognostic Value of HNRNPAB and Its Function in Breast Carcinoma. PMID:32509843
Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma. PMID:32509165
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint. PMID:32508832
Identification of immune-related biomarkers associated with tumorigenesis and prognosis in cutaneous melanoma patients. PMID:32508531
HK3 is correlated with immune infiltrates and predicts response to immunotherapy in non-small cell lung cancer. PMID:32508023
ATPase copper transporter A, negatively regulated by miR-148a-3p, contributes to cisplatin resistance in breast cancer cells. PMID:32508020
DSCAM-AS1-Driven Proliferation of Breast Cancer Cells Involves Regulation of Alternative Exon Splicing and 3'-End Usage. PMID:32503257
Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination. PMID:32502392
Rlip Depletion Suppresses Growth of Breast Cancer. PMID:32498332
Co-Regulation of Immune Checkpoint PD-L1 with Interferon-Gamma Signaling is Associated with a Survival Benefit in Renal Cell Cancer. PMID:32495158
Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy. PMID:32494745
RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability. PMID:32494026
GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors. PMID:32493985
Lysophosphatidic acid reverses Temsirolimus-induced changes in lipid droplets and mitochondrial networks in renal cancer cells. PMID:32492043
Study of Caspase 8 mutation in oral cancer and adjacent precancer tissues and implication in progression. PMID:32492030
Radiomics-based nomogram using CT imaging for noninvasive preoperative prediction of early recurrence in patients with hepatocellular carcinoma. PMID:32490826
Fibroblasts as a Biological Marker for Curative Resection in Pancreatic Ductal Adenocarcinoma. PMID:32485981
Molecular Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord-Stromal Tumors: A Contemporary Review. PMID:32485873
TRPM4 is overexpressed in breast cancer associated with estrogen response and epithelial-mesenchymal transition gene sets. PMID:32484822
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer. PMID:32483383
Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival. PMID:32481602
Co-Occurring Alterations of ERBB2 Exon 20 Insertion in Non-Small Cell Lung Cancer (NSCLC) and the Potential Indicator of Response to Afatinib. PMID:32477948
Computational analysis and verification of molecular genetic targets for glioblastoma. PMID:32469390
Genome-defined African ancestry is associated with distinct mutations and worse survival in patients with diffuse large B-cell lymphoma. PMID:32469082
Pan‑cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS‑CoV‑2 infection leading to COVID-19. PMID:32468052
Assessing the Role of the Interleukin-12/STAT4 Axis in Breast Cancer by a Bioinformatics Approach. PMID:32467824
Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers. PMID:32467608
Strategies for Functional Interrogation of Big Cancer Data Using Drosophila Cancer Models. PMID:32466549
The SLC Family Are Candidate Diagnostic and Prognostic Biomarkers in Clear Cell Renal Cell Carcinoma. PMID:32461965
Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes. PMID:32461624
Epigenetic downregulation of desmin in gall bladder cancer reveals its potential role in disease progression. PMID:32461394
Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma. PMID:32460791
RAC1 as a Therapeutic Target in Malignant Melanoma. PMID:32460002
Immunoscore Predicts Survival in Early-Stage Lung Adenocarcinoma Patients. PMID:32457841
Molecular patterns in salivary duct carcinoma identify prognostic subgroups. PMID:32457410
An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer. PMID:32455963
Caution in the management of SARS-CoV-2 infection in males. PMID:32452644
EMP2 Is a Novel Regulator of Stemness in Breast Cancer Cells. PMID:32451329
Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival. PMID:32445177
Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks. PMID:32444848
SNHG7 is a lncRNA oncogene controlled by Insulin-like Growth Factor signaling through a negative feedback loop to tightly regulate proliferation. PMID:32444795
Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection. PMID:32444418
Screening and identification of key biomarkers for retinoblastoma: Evidence from bioinformatics analysis. PMID:32443297
Targeting eIF3f Suppresses the Growth of Prostate Cancer Cells by Inhibiting Akt Signaling. PMID:32440143
Core Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network. PMID:32439761
Proliferation-associated long noncoding RNA, TMPO-AS1, is a potential therapeutic target for triple-negative breast cancer. PMID:32437068
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth. PMID:32433953
Comprehensive analysis of the value of RAB family genes in prognosis of breast invasive carcinoma. PMID:32432324
Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that PTEN Loss Contributes to Cetuximab Resistance in Head and Neck Cancer. PMID:32430488
Direct comparison shows that mRNA-based diagnostics incorporate information which cannot be learned directly from genomic mutations. PMID:32429832
Epigenetic Alterations in Oesophageal Cancer: Expression and Role of the Involved Enzymes. PMID:32429269
A novel role for NUAK1 in promoting ovarian cancer metastasis through regulation of fibronectin production in spheroids. PMID:32429240
SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation. PMID:32427938
Comparative analysis of MACROD1, MACROD2 and TARG1 expression, localisation and interactome. PMID:32427867
Targeting RLIP with CRISPR/Cas9 controls tumor growth. PMID:32426802
Detecting Cancer Survival Related Gene Markers Based on Rectified Factor Network. PMID:32426342
Homer1 is a Potential Biomarker for Prognosis in Human Colorectal Carcinoma, Possibly in Association with G3BP1 Signaling. PMID:32425603
Characterization of FANCL variants observed in patient cancer cells. PMID:32420600
MCM2 and NUSAP1 Are Potential Biomarkers for the Diagnosis and Prognosis of Pancreatic Cancer. PMID:32420375
Long-term survival with targeted therapy in an advanced non-small cell lung cancer patient based on genetic profiling. PMID:32420078
B-cell lymphoma 2 family genes show a molecular pattern of spatiotemporal heterogeneity in gynaecologic and breast cancer. PMID:32419250
Integrative Analysis of Periostin in Primary and Advanced Prostate Cancer. PMID:32416542
Performance of four platforms for KRAS mutation detection in plasma cell-free DNA: ddPCR, Idylla, COBAS z480 and BEAMing. PMID:32415199
DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis. PMID:32415104
Analyzing the prognostic value of DKK1 expression in human cancers based on bioinformatics. PMID:32411775
CRISPR screening identifies M1AP as a new MYC regulator with a promoter-reporter system. PMID:32411526
Sulfiredoxin as a Potential Therapeutic Target for Advanced and Metastatic Prostate Cancer. PMID:32411320
Mining the role of angiopoietin-like protein family in gastric cancer and seeking potential therapeutic targets by integrative bioinformatics analysis. PMID:32410376
Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model. PMID:32408898
ERα-related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer. PMID:32408897
Identification of transforming growth factor beta induced (TGFBI) as an immune-related prognostic factor in clear cell renal cell carcinoma (ccRCC). PMID:32406866
GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17. PMID:32405532
Molecular determinants underlying functional innovations of TBP and their impact on transcription initiation. PMID:32404905
In silico analyses identify lncRNAs: WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors. PMID:32401758
Diagnostic, progressive and prognostic performance of m6A methylation RNA regulators in lung adenocarcinoma. PMID:32398949
Systematic Multiomic Analysis of Ly75 Gene Expression and Its Prognostic Value Through the Infiltration of Natural Killer (NK) Cells in Skin Cutaneous Melanoma. PMID:32397120
Emerging Therapeutic Implications of STK11 Mutation: Case Series. PMID:32396674
Lower Levels of Adiponectin and Its Receptor Adipor1 in the Uveal Melanomas With Monosomy-3. PMID:32396633
CD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancer. PMID:32395395
Differentiation Syndrome with Ivosidenib and Enasidenib Treatment in Patients with Relapsed or Refractory IDH-Mutated AML: A U.S. Food and Drug Administration Systematic Analysis. PMID:32393603
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. PMID:32393580
Oviz-Bio: a web-based platform for interactive cancer genomics data visualization. PMID:32392343
E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells. PMID:32391871
Clinical and prognostic association of oncogene cadherin 11 in gastric cancer. PMID:32391104
Ribonucleotide reductase small subunit M2 is a master driver of aggressive prostate cancer. PMID:32385899
Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood. PMID:32385268
Expression of yhwaz and gene regulation network in hepatocellular carcinoma. PMID:32382342
Clinical and prognostic significance of MYH11 in lung cancer. PMID:32382337
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling. PMID:32381551
CCNE1 Amplification as a Predictive Biomarker of Chemotherapy Resistance in Epithelial Ovarian Cancer. PMID:32380689
Androgen attenuates the inactivating phospho-Ser-127 modification of yes-associated protein 1 (YAP1) and promotes YAP1 nuclear abundance and activity. PMID:32376689
The molecular basis of selective DNA binding by the BRG1 AT-hook and bromodomain. PMID:32376391
A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer. PMID:32371585
A Novel 4-Gene Score to Predict Survival, Distant Metastasis and Response to Neoadjuvant Therapy in Breast Cancer. PMID:32370309
Molecular Signatures of JMJD10/MINA53 in Gastric Cancer. PMID:32370161
Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST. PMID:32369930
Complement factor H-deficient mice develop spontaneous hepatic tumors. PMID:32369457
The roles and mechanisms of YTH domain-containing proteins in cancer development and progression. PMID:32368386
IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils. PMID:32366475
The Influence of Methylating Mutations on Acute Myeloid Leukemia: Preliminary Analysis on 56 Patients. PMID:32365516
Molecular and Clinical Relevance of ZBTB38 Expression Levels in Prostate Cancer. PMID:32365491
Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases. PMID:32365229
Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth. PMID:32358581
PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. PMID:32358509
Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer. PMID:32357907
The Clinical Significance of PIWIL3 and PIWIL4 Expression in Pancreatic Cancer. PMID:32357464
Tumor-Infiltrating CD8 T Cells Predict Clinical Breast Cancer Outcomes in Young Women. PMID:32357420
Integrated bioinformatics analysis of expression and gene regulation network of COL12A1 in colorectal cancer. PMID:32356618
CPS1 expression and its prognostic significance in lung adenocarcinoma. PMID:32355785
Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity. PMID:32355214
Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish. PMID:32354205
The Role of Crosstalk between AR3 and E2F1 in Drug Resistance in Prostate Cancer Cells. PMID:32354165
Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors. PMID:32352724
BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression. PMID:32352029
Erlotinib sensitivity of MAPK1p.D321N mutation in head and neck squamous cell carcinoma. PMID:32351709
Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma. PMID:32350415
Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer. PMID:32350277
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation. PMID:32350249
Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma: A Functional Assessment Based on Actin Three-Dimensional Structures. PMID:32349449
Comprehensive Analysis of the Expression and Prognosis for TDO2 in Breast Cancer. PMID:32346606
Co-occurrent Alterations of Alzheimer's Genes and Prostate Cancer Genes in Prostate Cancer. PMID:32345668
The F-box protein FBXL16 up-regulates the stability of C-MYC oncoprotein by antagonizing the activity of the F-box protein FBW7. PMID:32345600
The duality of human oncoproteins: drivers of cancer and congenital disorders. PMID:32341551
Association Between Spatial Heterogeneity Within Nonmetastatic Gastroesophageal Adenocarcinomas and Survival. PMID:32338752
Identification of a metabolic gene panel to predict the prognosis of myelodysplastic syndrome. PMID:32337851
The Oncogenic Role of CENPA in Hepatocellular Carcinoma Development: Evidence from Bioinformatic Analysis. PMID:32337237
Kinome multigenic panel identified novel druggable EPHB4-V871I somatic variant in high-risk neuroblastoma. PMID:32336043
Identification of METTL3 as an Adverse Prognostic Biomarker in Hepatocellular Carcinoma. PMID:32333311
Pan-cancer analysis identifies mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation. PMID:32332164
G2M Cell Cycle Pathway Score as a Prognostic Biomarker of Metastasis in Estrogen Receptor (ER)-Positive Breast Cancer. PMID:32331421
HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity. PMID:32331382
Resveratrol Promotes Tumor Microvessel Growth via Endoglin and Extracellular Signal-Regulated Kinase Signaling Pathway and Enhances the Anticancer Efficacy of Gemcitabine against Lung Cancer. PMID:32326402
IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. PMID:32325700
Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy. PMID:32325691
Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis. PMID:32325032
Targeting Rac and Cdc42 GEFs in Metastatic Cancer. PMID:32322580
High-throughput gene screen reveals modulators of nuclear shape. PMID:32320319
Robust Biomarker Screening Using Spares Learning Approach for Liver Cancer Prognosis. PMID:32318552
Prognostic significance of an invasive leader cell-derived mutation cluster on chromosome 16q. PMID:32315457
Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone. PMID:32314873
Downregulation of α-l-fucosidase 1 suppresses glioma progression by enhancing autophagy and inhibiting macrophage infiltration. PMID:32314457
ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes. PMID:32313225
Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model. PMID:32313004
TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism. PMID:32312982
Overexpression of COL24A1 in Hepatocellular Carcinoma Predicts Poor Prognosis: A Study Based on Multiple Databases, Clinical Samples and Cell Lines. PMID:32308416
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. PMID:32302568
Plasma membrane expression of G protein-coupled estrogen receptor (GPER)/G protein-coupled receptor 30 (GPR30) is associated with worse outcome in metachronous contralateral breast cancer. PMID:32302351
CREB1 is affected by the microRNAs miR-22-3p, miR-26a-5p, miR-27a-3p, and miR-221-3p and correlates with adverse clinicopathological features in renal cell carcinoma. PMID:32300145
Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer. PMID:32300050
Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib. PMID:32297440
Comprehensive Analysis of AR Alterations in Circulating Tumor DNA from Patients with Advanced Prostate Cancer. PMID:32297439
Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington's Disease. PMID:32295075
Mutational landscape and characteristics of ERBB2 in non-small cell lung cancer. PMID:32291971
Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. PMID:32289751
CCNB2 and AURKA overexpression may cause atypical mitosis in Japanese cortisol-producing adrenocortical carcinoma with TP53 somatic variant. PMID:32287321
Re-definition of claudin-low as a breast cancer phenotype. PMID:32286297
The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma. PMID:32284793
Dissecting Anaplastic Thyroid Carcinoma: A Comprehensive Clinical, Histologic, Immunophenotypic, and Molecular Study of 360 Cases. PMID:32284020
Characterization of the prognostic values and response to immunotherapy/chemotherapy of Krüppel-like factors in prostate cancer. PMID:32281273
Peroxisome proliferator-activated receptor gamma as a theragnostic target for mesenchymal-type glioblastoma patients. PMID:32280134
The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxia-inducible factor 1α in liver cancer cells. PMID:32277050
High-Throughput Sequencing Identifies 3 Novel Susceptibility Genes for Hereditary Melanoma. PMID:32276436
PCNA-associated factor KIAA0101 transcriptionally induced by ELK1 controls cell proliferation and apoptosis in nasopharyngeal carcinoma: an integrated bioinformatics and experimental study. PMID:32275642
ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 while ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition. PMID:32272809
The Receptor Tyrosine Kinase RON and Its Isoforms as Therapeutic Targets in Ewing Sarcoma. PMID:32272784
Identification of core genes associated with prostate cancer progression and outcome via bioinformatics analysis in multiple databases. PMID:32266115
DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation. PMID:32264658
Urine Endocannabinoids as Novel Non-Invasive Biomarkers for Bladder Cancer at Early Stage. PMID:32260109
Evaluation of X-Ray Repair Cross-Complementing Family Members as Potential Biomarkers for Predicting Progression and Prognosis in Hepatocellular Carcinoma. PMID:32258128
Lentiviral Gene Therapy for Familial Hemophagocytic Lymphohistiocytosis Type 3, Caused by UNC13D Genetic Defects. PMID:32253931
Genomics of MPNST (GeM) Consortium: Rationale and Study Design for Multi-Omic Characterization of NF1-Associated and Sporadic MPNSTs. PMID:32252413
The pan-cancer landscape of netrin family reveals potential oncogenic biomarkers. PMID:32251318
CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation. PMID:32249801
Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells. PMID:32249776
The Mystery of Rap1 Suppression of Oncogenic Ras. PMID:32249186
Actionable Potentials of Less Frequently Mutated Genes in Colorectal Cancer and Their Roles in Precision Medicine. PMID:32245111
The Missing Lnc: The Potential of Targeting Triple-Negative Breast Cancer and Cancer Stem Cells by Inhibiting Long Non-Coding RNAs. PMID:32244924
SAMHD1 Functions and Human Diseases. PMID:32244340
Developing Organoids from Ovarian Cancer as Experimental and Preclinical Models. PMID:32243841
KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer. PMID:32243837
Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts. PMID:32240795
Meta-Analysis Based on Nonconvex Regularization. PMID:32238826
Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis. PMID:32238586
PRKDC: new biomarker and drug target for checkpoint blockade immunotherapy. PMID:32238472
Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy. PMID:32238357
LCK expression is a potential biomarker for distinguishing primary central nervous system lymphoma from glioblastoma multiforme. PMID:32237064
Multi-omics Visualization Platform: An extensible Galaxy plug-in for multi-omics data visualization and exploration. PMID:32236523
Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression. PMID:32235890
Development of a prognostic index and screening of potential biomarkers based on immunogenomic landscape analysis of colorectal cancer. PMID:32235004
LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma. PMID:32234847
Metastatic Melanoma Patient-Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition. PMID:32234759
Beyond repression of Nrf2: An update on Keap1. PMID:32234331
Controversies around the function of LARP1. PMID:32233986
Transcriptomic and Functional Screens Reveal MicroRNAs That Modulate Prostate Cancer Metastasis. PMID:32231998
Histone methyltransferase SETD2: a potential tumor suppressor in solid cancers. PMID:32231741
Landscape of BRIP1 molecular lesions in gastrointestinal cancers from published genomic studies. PMID:32231423
Therapeutically actionable PAK4 is amplified, overexpressed, and involved in bladder cancer progression. PMID:32231273
Bioinformatics Analysis of Prognostic Tumor Microenvironment-Related Genes in the Tumor Microenvironment of Hepatocellular Carcinoma. PMID:32231177
Vitamin D Suppresses Ovarian Cancer Growth and Invasion by Targeting Long Non-Coding RNA CCAT2. PMID:32230936
Extracellular Protease ADAMTS1 Is Required at Early Stages of Human Uveal Melanoma Development by Inducing Stemness and Endothelial-Like Features on Tumor Cells. PMID:32230715
Upregulation of deubiquitinase PSMD14 in lung adenocarcinoma (LUAD) and its prognostic significance. PMID:32226511
Decreased Expression of NUSAP1 Predicts Poor Overall Survival in Cervical Cancer. PMID:32226503
Effect of CELSR3 on the Cell Cycle and Apoptosis of Hepatocellular Carcinoma Cells. PMID:32226501
Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation. PMID:32226312
Nucleotide binding domain and leucine-rich repeat pyrin domain-containing protein 12: characterization of its binding to hematopoietic cell kinase. PMID:32226298
Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2. PMID:32224897
Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts. PMID:32220884
Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer. PMID:32219437
Transcription levels and prognostic significance of the NFI family members in human cancers. PMID:32219034
Intratumoral heterogeneity of glutaminase and lactate dehydrogenase A protein expression in colorectal cancer. PMID:32218849
High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC. PMID:32216563
Microbiome analyses of blood and tissues suggest cancer diagnostic approach. PMID:32214244
Coordination of mRNA and tRNA methylations by TRMT10A. PMID:32213595
Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis. PMID:32213586
RNF168-Mediated Ubiquitin Signaling Inhibits the Viability of BRCA1-Null Cancers. PMID:32213544
Cytokines secreted by stromal cells in TNBC microenvironment as potential targets for cancer therapy. PMID:32213106
Regulatory Mechanism of ITGBL1 in the Metastasis of Colorectal Cancer. PMID:32211321
OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine. PMID:32210335
HER2 as a potential biomarker of lymph node metastasis in undifferentiated early gastric cancer. PMID:32210254
Molecular Mechanism of Aflatoxin-Induced Hepatocellular Carcinoma Derived from a Bioinformatics Analysis. PMID:32210020
Wild-Type IDH1 and Mutant IDH1 Opposingly Regulate Podoplanin Expression in Glioma. PMID:32208352
PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation. PMID:32206121
The potential drug for treatment in pancreatic adenocarcinoma: a bioinformatical study based on distinct drug databases. PMID:32206083
Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis. PMID:32205868
Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. PMID:32205440
Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells. PMID:32203164
Comprehensive bioinformatic analysis of Wnt1 and Wnt1-associated diseases. PMID:32201670
CD148 Serves as a Prognostic Marker of Gastric Cancer and Hinders Tumor Progression by Dephosphorylating EGFR. PMID:32201537
Integrative Analysis of Siglec-15 mRNA in Human Cancers Based on Data Mining. PMID:32201516
Comparative genomic profiling of glandular bladder tumours. PMID:32198650
Dual regulation of p53 by the ribosome maturation factor SBDS. PMID:32198344
The tubal epigenome - An emerging target for ovarian cancer. PMID:32197795
Identification of hub driving genes and regulators of lung adenocarcinoma based on the gene Co-expression network. PMID:32196072
Immune and Stroma Related Genes in Breast Cancer: A Comprehensive Analysis of Tumor Microenvironment Based on the Cancer Genome Atlas (TCGA) Database. PMID:32195260
FAM83A Promotes Lung Cancer Progression by Regulating the Wnt and Hippo Signaling Pathways and Indicates Poor Prognosis. PMID:32195172
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis. PMID:32195105
Identification and validation of HELLS (Helicase, Lymphoid-Specific) and ICAM1 (Intercellular adhesion molecule 1) as potential diagnostic biomarkers of lung cancer. PMID:32195055
FGD1 promotes tumor progression and regulates tumor immune response in osteosarcoma via inhibiting PTEN activity. PMID:32194840
Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma. PMID:32194798
Expression levels and associations of five long non-coding RNAs in gastric cancer and their clinical significance. PMID:32194743
ZW10 interacting kinetochore protein may serve as a prognostic biomarker for human breast cancer: An integrated bioinformatics analysis. PMID:32194714
Integrated Analysis of the Functions and Prognostic Values of RNA Binding Proteins in Lung Squamous Cell Carcinoma. PMID:32194639
LINC00319-Mediated miR-3127 Repression Enhances Bladder Cancer Progression Through Upregulation of RAP2A. PMID:32194636
Integrated analysis of gene expression and DNA methylation profiles in ovarian cancer. PMID:32192517
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome. PMID:32188943
Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer. PMID:32188493
Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma. PMID:32188490
Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. PMID:32184446
The Oncogenic Potential of the Centromeric Border Protein FAM84B of the 8q24.21 Gene Desert. PMID:32183428
ATM-Deficient Cancers Provide New Opportunities for Precision Oncology. PMID:32183301
The Role of Polycomb Repressive Complex in Malignant Peripheral Nerve Sheath Tumor. PMID:32182803
Identification of key genes and pathways of diagnosis and prognosis in cervical cancer by bioinformatics analysis. PMID:32181600
Gene Expression Alterations and Molecular Analysis of CHEK1 in Solid Tumors. PMID:32178478
Hormone Receptor-Positive/Human Epidermal Growth Receptor 2-Negative Metastatic Breast Cancer in Young Women: Emerging Data in the Era of Molecularly Targeted Agents. PMID:32176406
Pan-cancer analysis of KEAP1 mutations as biomarkers for immunotherapy outcomes. PMID:32175433
Systematical Analysis of the Cancer Genome Atlas Database Reveals EMCN/MUC15 Combination as a Prognostic Signature for Gastric Cancer. PMID:32175327
FBXW4 Is Highly Expressed and Associated With Poor Survival in Acute Myeloid Leukemia. PMID:32175272
Expression patterns and the prognostic value of the EMILIN/Multimerin family members in low-grade glioma. PMID:32175193
Gene mutations distinguishing gastric from colorectal and esophageal adenocarcinomas. PMID:32175104
SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism. PMID:32166001
Defects in DNA Repair Genes Confer Improved Long-term Survival after Cisplatin-based Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer. PMID:32165095
Tumor mutational burden is associated with poor outcomes in diffuse glioma. PMID:32164609
Identification of potential novel biomarkers to differentiate malignant thyroid nodules with cytological indeterminate. PMID:32164602
Metagenomic characterization of lysine acetyltransferases in human cancer and their association with clinicopathologic features. PMID:32162442
Integrative Analysis of Sirtuins and Their Prognostic Significance in Clear Cell Renal Cell Carcinoma. PMID:32158696
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways. PMID:32156008
Integrated analysis of gene expression, alteration and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer. PMID:32154045
Targeting Chromosomal Architectural HMGB Proteins Could Be the Next Frontier in Cancer Therapy. PMID:32152151
The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis. PMID:32151005
The Application of Deep Learning in Cancer Prognosis Prediction. PMID:32150991
AXL as a Target in Breast Cancer Therapy. PMID:32148495
A Novel System for Functional Determination of Variants of Uncertain Significance using Deep Convolutional Neural Networks. PMID:32144301
Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain. PMID:32143622
The G Protein-Coupled Estrogen Receptor (GPER) Expression Correlates with Pro-Metastatic Pathways in ER-Negative Breast Cancer: A Bioinformatics Analysis. PMID:32143514
Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer. PMID:32142667
OncoMX: A Knowledgebase for Exploring Cancer Biomarkers in the Context of Related Cancer and Healthy Data. PMID:32142370
Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity. PMID:32140747
Label-free quantitative identification of abnormally ubiquitinated proteins as useful biomarkers for human lung squamous cell carcinomas. PMID:32140187
The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer. PMID:32139876
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy. PMID:32139506
PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models. PMID:32139402
miR-221-3p Regulates VEGFR2 Expression in High-Risk Prostate Cancer and Represents an Escape Mechanism from Sunitinib In Vitro. PMID:32131507
Non-Thermal Plasma Induces Antileukemic Effect Through mTOR Ubiquitination. PMID:32131492
Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells. PMID:32128997
Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer. PMID:32127696
HDMAC: A Web-Based Interactive Program for High-Dimensional Analysis of Molecular Alterations in Cancer. PMID:32127576
Muscleblind-like 2 controls the hypoxia response of cancer cells. PMID:32127384
Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis. PMID:32123305
Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells. PMID:32123273
Mutations in the coat complex II component SEC23B promote colorectal cancer metastasis. PMID:32123160
Melanoma in the Eyes of Mechanobiology. PMID:32117980
Prioritizing Gene Cascading Paths to Model Colorectal Cancer Through Engineered Organoids. PMID:32117908
Identification of Therapeutic Targets and Prognostic Biomarkers Among CXC Chemokines in the Renal Cell Carcinoma Microenvironment. PMID:32117786
Comprehensive Review of Web Servers and Bioinformatics Tools for Cancer Prognosis Analysis. PMID:32117725
The Functional Effects of Key Driver KRAS Mutations on Gene Expression in Lung Cancer. PMID:32117436
Programmed death-ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21-gene and 70-gene signatures in estrogen receptor-positive disease. PMID:32115850
Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells. PMID:32112300
Synaptotagmin 12 (SYT12) Gene Expression Promotes Cell Proliferation and Progression of Lung Adenocarcinoma and Involves the Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway. PMID:32108133
Identification of Novel Prognosis and Prediction Markers in Advanced Prostate Cancer Tissues Based on Quantitative Proteomics. PMID:32108042
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data. PMID:32107691
Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma. PMID:32104684
Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer. PMID:32103870
Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3. PMID:32102440
Efficacy of Cabozantinib and Nivolumab in Treating Hepatocellular Carcinoma with RET Amplification, High Tumor Mutational Burden, and PD-L1 Expression. PMID:32100934
Bioinformatics Analysis and RNA-Sequencing of SCAMP3 Expression and Correlated Gene Regulation in Hepatocellular Carcinoma. PMID:32099407
A transcriptional co-expression network-based approach to identify prognostic biomarkers in gastric carcinoma. PMID:32095347
Immunohistochemistry-based assessment of androgen receptor status and the AR-null phenotype in metastatic castrate resistant prostate cancer. PMID:32094488
Increased Expression of Micro-RNA-23a Mediates Chemoresistance to Cytarabine in Acute Myeloid Leukemia. PMID:32093419
SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt/β-catenin signaling pathway. PMID:32091407
Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers. PMID:32087759
Transcriptome Analysis Identifies ALCAM Overexpression as a Prognosis Biomarker in Laryngeal Squamous Cell Carcinoma. PMID:32085563
Genetic alterations of malignant pleural mesothelioma: association with tumor heterogeneity and overall survival. PMID:32083805
Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma. PMID:32083006
Systematic analysis of the Hippo pathway organization and oncogenic alteration in evolution. PMID:32081887
Expression and prognostic value of long non-coding RNA H19 in glioma via integrated bioinformatics analyses. PMID:32081833
Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer. PMID:32080887
Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. PMID:32080622
Multi-omics Data Integration, Interpretation, and Its Application. PMID:32076369
Dickkopf-2 (DKK2) as Context Dependent Factor in Patients with Esophageal Adenocarcinoma. PMID:32075129
Epigenetics of SFRP1: The Dual Roles in Human Cancers. PMID:32074995
Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy. PMID:32074012
SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness. PMID:32071280
STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype. PMID:32068166
Fallopian tube initiation of high grade serous ovarian cancer and ovarian metastasis: Mechanisms and therapeutic implications. PMID:32067992
Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis. PMID:32067422
Homologous recombination deficiency status-based classification of high-grade serous ovarian carcinoma. PMID:32066851
DNA repair gene expression is associated with differential prognosis between HPV16 and HPV18 positive cervical cancer patients following radiation therapy. PMID:32066835
Machine Learning and Bioinformatics Models to Identify Pathways that Mediate Influences of Welding Fumes on Cancer Progression. PMID:32066756
A role for caveola-forming proteins caveolin-1 and CAVIN1 in the pro-invasive response of glioblastoma to osmotic and hydrostatic pressure. PMID:32065471
Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer. PMID:32061630
Identification and validation of key genes with prognostic value in non-small-cell lung cancer via integrated bioinformatics analysis. PMID:32059076
DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation. PMID:32058953
The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis. PMID:32057095
Exploration of databases and methods supporting drug repurposing: a comprehensive survey. PMID:32055842
Genetic alterations related to endoscopic treatment of colorectal tumors. PMID:32055701
Detection of pancreatic ductal adenocarcinoma with galectin-9 serum levels. PMID:32055023
LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance. PMID:32054769
Mechanical regulation of glycolysis via cytoskeleton architecture. PMID:32051585
Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal. PMID:32050609
Development and validation of a novel immune-related prognostic model in hepatocellular carcinoma. PMID:32046766
Separated Siamese Twins: Intronic Small Nucleolar RNAs and Matched Host Genes May be Altered in Conjunction or Separately in Multiple Cancer Types. PMID:32046192
Novel ESCC-related gene ZNF750 as potential Prognostic biomarker and inhibits Epithelial-Mesenchymal Transition through directly depressing SNAI1 promoter in ESCC. PMID:32042337
Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts. PMID:32042320
Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling. PMID:32042113
The role of RICTOR amplification in targeted therapy and drug resistance. PMID:32041519
Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night. PMID:32041394
Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae. PMID:32041123
Analysis of the Differentially Expressed Genes Induced by Cisplatin Resistance in Oral Squamous Cell Carcinomas and Their Interaction. PMID:32038705
APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. PMID:32037952
MET targeting: time for a rematch. PMID:32034310
Cyclin-Dependent Kinase and Antioxidant Gene Expression in Cancers with Poor Therapeutic Response. PMID:32033319
Synergy between Non-Thermal Plasma with Radiation Therapy and Olaparib in a Panel of Breast Cancer Cell Lines. PMID:32033118
Opposite Roles of BAP1 in Overall Survival of Uveal Melanoma and Cutaneous Melanoma. PMID:32028647
Notch1/2/3/4 are prognostic biomarker and correlated with immune infiltrates in gastric cancer. PMID:32028262
Thyroid Carcinomas That Occur in Familial Adenomatous Polyposis Patients Recurrently Harbor Somatic Variants in APC, BRAF, and KTM2D. PMID:32024448
Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma. PMID:32023450
Oncogene-dependent function of BRG1 in hepatocarcinogenesis. PMID:32019910
Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches. PMID:32019869
Integrative analysis of highly mutated genes in hepatitis B virus-related hepatic carcinoma. PMID:32017470
Role of downregulated ADARB1 in lung squamous cell carcinoma. PMID:32016472
Identification of cancer driver genes based on nucleotide context. PMID:32015527
Inhibition of the deubiquitinase USP10 induces degradation of SYK. PMID:32015510
Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics. PMID:32010623
Genomic Features and Clinical Characteristics of Adolescents and Young Adults With Cholangiocarcinoma. PMID:32010606
Cyclin D1 expression as a potential prognostic factor in advanced KRAS-mutant non-small cell lung cancer. PMID:32010574
Comparative expression analysis in small cell lung carcinoma reveals neuroendocrine pattern change in primary tumor versus lymph node metastases. PMID:32010572
Inhibiting the Activity of NADPH Oxidase in Cancer. PMID:32008376
Grainyhead-like transcription factors in cancer - Focus on recent developments. PMID:32008358
High expression of SMYD3 indicates poor survival outcome and promotes tumour progression through an IGF-1R/AKT/E2F-1 positive feedback loop in bladder cancer. PMID:32007952
Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone. PMID:32007910
Adult Human Glioblastomas Harbor Radial Glia-like Cells. PMID:32004492
Clinical characteristics of malignant melanoma in central China and predictors of metastasis. PMID:32002034
Bioinformatics-based screening of key genes for transformation of liver cirrhosis to hepatocellular carcinoma. PMID:32000807
Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients. PMID:32000721
Differentially expressed genes and key molecules of BRCA1/2-mutant breast cancer: evidence from bioinformatics analyses. PMID:31998560
Phase II Trial of Cabozantinib in Recurrent/Metastatic Endometrial Cancer: A Study of the Princess Margaret, Chicago, and California Consortia (NCI9322/PHL86). PMID:31992589
Evidence-Based Network Approach to Recommending Targeted Cancer Therapies. PMID:31990579
Carcinogenesis effects of E2F transcription factor 8 (E2F8) in hepatocellular carcinoma outcomes: an integrated bioinformatic report. PMID:31990034
PIK3CA gene aberrancy and role in targeted therapy of solid malignancies. PMID:31988478
Low-frequency TP53 hotspot mutation contributes to chemoresistance through clonal expansion in acute myeloid leukemia. PMID:31988438
Patient similarity by joint matrix trifactorization to identify subgroups in acute myeloid leukemia. PMID:31984320
Mesothelioma: Hippo pathway as a target, lessons from COMMAND. PMID:31976036
Replisome genes regulation by antitumor miR-101-5p in clear cell renal cell carcinoma. PMID:31975570
Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing. PMID:31974171
A Multi-Omics Analysis of Bone Morphogenetic Protein 5 (BMP5) mRNA Expression and Clinical Prognostic Outcomes in Different Cancers Using Bioinformatics Approaches. PMID:31973134
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform. PMID:31971940
Genetic alterations of interleukin-17 and related genes in human prostate cancer. PMID:31970232
Co-regulation of the antagonistic RepoMan:Aurora-B pair in proliferating cells. PMID:31967936
Tracking the important role of JUNB in hepatocellular carcinoma by single-cell sequencing analysis. PMID:31966074
IDH1-R132H mutation radiosensitizes U87MG glioma cells via epigenetic downregulation of TIGAR. PMID:31966064
Downregulation of LINC01140 is associated with adverse features of breast cancer. PMID:31966045
Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis. PMID:31964905
A qualitative transcriptional signature for predicting the biochemical recurrence risk of prostate cancer patients after radical prostatectomy. PMID:31961962
HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair. PMID:31960047
Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers. PMID:31959902
Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity. PMID:31959836
Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression. PMID:31957540
Germline mutations of SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type and in SMARCA4-deficient undifferentiated uterine sarcoma: Clinical features of a single family and comparison of large cohorts. PMID:31954538
Variable Mutations at the p53-R273 Oncogenic Hotspot Position Leads to Altered Properties. PMID:31952808
Single-molecule detection of cancer mutations using a novel PCR-LDR-qPCR assay. PMID:31950578
miR-TV: an interactive microRNA Target Viewer for microRNA and target gene expression interrogation for human cancer studies. PMID:31950188
Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer. PMID:31949146
Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis. PMID:31949145
Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment. PMID:31944090
Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer. PMID:31942683
Combining Bioinformatics and Experiments to Identify and Verify Key Genes with Prognostic Values in Endometrial Carcinoma. PMID:31942195
MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer. PMID:31942031
FOXD3 Regulates VISTA Expression in Melanoma. PMID:31940493
Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma. PMID:31939622
Clinical implication of UCA1 in non-small cell lung cancer and its effect on caspase-3/7 activation and apoptosis induction in vitro. PMID:31938341
Bioinformatic analysis of differential expression and core GENEs in breast cancer. PMID:31938209
Cell adhesion in cancer: Beyond the migration of single cells. PMID:31937589
Sorafenib Inhibits Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in Hepatocellular Carcinoma Cells. PMID:31936661
Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis. PMID:31935372
The clinical significance of CHEK1 in breast cancer: a high-throughput data analysis and immunohistochemical study. PMID:31933717
The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity. PMID:31932812
C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts. PMID:31931851
Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer. PMID:31930723
Somatic genetic aberrations in gallbladder cancer: comparison between Chinese and US patients. PMID:31929987
Prognostic potential of PRPF3 in hepatocellular carcinoma. PMID:31926109
Trametinib Activity in Patients with Solid Tumors and Lymphomas Harboring BRAF Non-V600 Mutations or Fusions: Results from NCI-MATCH (EAY131). PMID:31924734
Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors. PMID:31923184
Emerging Functions of Human IFIT Proteins in Cancer. PMID:31921891
Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4. PMID:31921386
TRIP13 regulates DNA repair pathway choice through REV7 conformational change. PMID:31915374
Prognostic value of epithelial-mesenchymal transition markers in clear cell renal cell carcinoma. PMID:31915310
Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance. PMID:31914141
Advancing RAS/RASopathy therapies: An NCI-sponsored intramural and extramural collaboration for the study of RASopathies. PMID:31913576
Multi-regional sequencing reveals clonal and polyclonal seeding from primary tumor to metastases in advanced gastric cancer. PMID:31912238
Integrative network analysis identifies cell-specific trans regulators of m6A. PMID:31912146
Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR-Mutant Lung Cancer. PMID:31911548
Omics-based integrated analysis identified ATRX as a biomarker associated with glioma diagnosis and prognosis. PMID:31908895
UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop. PMID:31907353
High MYC mRNA Expression Is More Clinically Relevant than MYC DNA Amplification in Triple-Negative Breast Cancer. PMID:31905596
SIRPB1 promotes prostate cancer cell proliferation via Akt activation. PMID:31905248
The correlation and role analysis of COL4A1 and COL4A2 in hepatocarcinogenesis. PMID:31905170
The prognostic value of tumor mutation burden in EGFR-mutant advanced lung adenocarcinoma, an analysis based on cBioPortal data base. PMID:31903239
Therapeutic options for mucinous ovarian carcinoma. PMID:31902686
Multi-cancer V-ATPase molecular signatures: A distinctive balance of subunit C isoforms in esophageal carcinoma. PMID:31901859
Retained or altered expression of major histocompatibility complex class I in patient-derived xenograft models in breast cancer. PMID:31900802
Harnessing big 'omics' data and AI for drug discovery in hepatocellular carcinoma. PMID:31900465
Spitz melanoma is a distinct subset of spitzoid melanoma. PMID:31900433
CaSpER identifies and visualizes CNV events by integrative analysis of single-cell or bulk RNA-sequencing data. PMID:31900397
A regulatory role for CHD2 in myelopoiesis. PMID:31900031
TRPV6 as A Target for Cancer Therapy. PMID:31897233
Bioinformatics analysis of the expression of HOXC13 and its role in the prognosis of breast cancer. PMID:31897205
Genome-wide analysis reveals the emerging roles of long non-coding RNAs in cancer. PMID:31897174
FNDC3B is associated with ER stress and poor prognosis in cervical cancer. PMID:31897153
ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity. PMID:31895940
High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation. PMID:31892360
Discovering Rare Genes Contributing to Cancer Stemness and Invasive Potential by GBM Single-Cell Transcriptional Analysis. PMID:31888172
Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma. PMID:31887619
Matrisome-Associated Gene Expression Patterns Correlating with TIMP2 in Cancer. PMID:31882975
Single Nucleotide Polymorphism rs6942067 Is a Risk Factor in Young and in Non-Smoking Patients with HPV Negative Head and Neck Squamous Cell Carcinoma. PMID:31878157
Immunohistochemical Analysis Revealed a Correlation between Musashi-2 and Cyclin-D1 Expression in Patients with Oral Squamous Cells Carcinoma. PMID:31878037
Membrane Anchoring of Hck Kinase via the Intrinsically Disordered SH4-U and Length Scale Associated with Subcellular Localization. PMID:31877324
Increased Risk of Acute Myelogenous Leukemia After Early Onset but Not Late-Onset Colorectal Cancer. PMID:31876540
Genomics of lethal prostate cancer at diagnosis and castration resistance. PMID:31874108
Fluorouracil sensitivity in a head and neck squamous cell carcinoma with a somatic DPYD structural variant. PMID:31871216
SMAD4 Somatic Mutations in Head and Neck Carcinoma Are Associated With Tumor Progression. PMID:31867281
The Thyroid Hormone Receptor-RUNX2 Axis: A Novel Tumor Suppressive Pathway in Breast Cancer. PMID:31865591
PIK3CA and KRAS Amplification in Esophageal Adenocarcinoma and their Impact on the Inflammatory Tumor Microenvironment and Prognosis. PMID:31865178
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth. PMID:31863007
Reactive Oxygen Species Drive Proliferation in Acute Myeloid Leukemia via the Glycolytic Regulator PFKFB3. PMID:31862780
Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma. PMID:31862696
Modulation of proliferation factors in lung adenocarcinoma with an analysis of the transcriptional consequences of genomic EGFR activation. PMID:31857847
eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/β-catenin in gastric cancer. PMID:31853750
Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer. PMID:31852841
Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer. PMID:31849319
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function. PMID:31848340
FIREVAT: finding reliable variants without artifacts in human cancer samples using etiologically relevant mutational signatures. PMID:31847917
FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1. PMID:31846430
Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer. PMID:31844668
MicroRNA-338-3p suppresses ovarian cancer cells growth and metastasis: implication of Wnt/catenin beta and MEK/ERK signaling pathways. PMID:31842953
Preoperative plasma fatty acid metabolites inform risk of prostate cancer progression and may be used for personalized patient stratification. PMID:31842810
LncRNA MAGI2-AS3 Is Regulated by BRD4 and Promotes Gastric Cancer Progression via Maintaining ZEB1 Overexpression by Sponging miR-141/200a. PMID:31837602
Systematic expression analysis of WEE family kinases reveals the importance of PKMYT1 in breast carcinogenesis. PMID:31837068
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy. PMID:31836706
Heterogeneous alteration of the ERBB3-MYC axis associated with MEK inhibitor resistance in a KRAS-mutated low-grade serous ovarian cancer patient. PMID:31836588
Prostate-Derived ETS Factor (PDEF) Modulates Yes Associated Protein 1 (YAP1) in Prostate Cancer Cells: A Potential Cross-Talk between PDEF and Hippo Signaling. PMID:31835563
Harmonization of Tumor Mutational Burden Quantification and Association With Response to Immune Checkpoint Blockade in Non-Small-Cell Lung Cancer. PMID:31832578
Dickkopf-related protein 1, a new biomarker for local immune status and poor prognosis among patients with colorectal liver Oligometastases: a retrospective study. PMID:31830954
Clinical significance of stromal ER and PR expression in periampullary adenocarcinoma. PMID:31827798
MAP2K1 is a potential therapeutic target in erlotinib resistant head and neck squamous cell carcinoma. PMID:31827134
A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. PMID:31825826
NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma. PMID:31824170
TrkA overexpression in non-tumorigenic human breast cell lines confers oncogenic and metastatic properties. PMID:31823098
Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer. PMID:31822799
Transient receptor potential cation channel subfamily V and breast cancer. PMID:31822791
PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization. PMID:31822657
Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer. PMID:31822495
Prognostic value of immune-related genes in clear cell renal cell carcinoma. PMID:31821170
MIR22HG As A Tumor Suppressive lncRNA In HCC: A Comprehensive Analysis Integrating RT-qPCR, mRNA-Seq, And Microarrays. PMID:31819482
High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer. PMID:31819188
Increased inflammatory lipid metabolism and anaplerotic mitochondrial activation follow acquired resistance to vemurafenib in BRAF-mutant melanoma cells. PMID:31819183
Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen. PMID:31819114
Aberrant activation of hepatocyte growth factor/MET signaling promotes β-catenin-mediated prostatic tumorigenesis. PMID:31819003
Newly Developed CK1-Specific Inhibitors Show Specifically Stronger Effects on CK1 Mutants and Colon Cancer Cell Lines. PMID:31817920
Pannexin1 Is Associated with Enhanced Epithelial-To-Mesenchymal Transition in Human Patient Breast Cancer Tissues and in Breast Cancer Cell Lines. PMID:31817827
TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-κB Signaling Cascade. PMID:31817720
Collagen prolyl 4-hydroxylase 2 predicts worse prognosis and promotes glycolysis in cervical cancer. PMID:31814898
Identification of potential core genes in metastatic renal cell carcinoma using bioinformatics analysis. PMID:31814889
GliomaDB: A Web Server for Integrating Glioma Omics Data and Interactive Analysis. PMID:31811943
The most common RNF43 mutant G659Vfs*41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis. PMID:31811196
Bioinformatics Analysis of Expression and Alterations of BARD1 in Breast Cancer. PMID:31808361
Expression And Biological Interaction Network Of RHOC For Hepatic Carcinoma With Metastasis In PBMC Samples. PMID:31806997
The Impact of High-mobility Group Box Mutation of T-cell Factor 4 on Its Genomic Binding Pattern in Non-small Cell Lung Cancer. PMID:31805518
IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader. PMID:31804607
Insight Into the Role of Autophagy in Osteosarcoma and Its Therapeutic Implication. PMID:31803616
Identification of a Five-Gene Signature and Establishment of a Prognostic Nomogram to Predict Progression-Free Interval of Papillary Thyroid Carcinoma. PMID:31803141
Genetic And Epigenetic Regulation Of E-Cadherin Signaling In Human Hepatocellular Carcinoma. PMID:31802937
Cardioinformatics: the nexus of bioinformatics and precision cardiology. PMID:31802103
Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function. PMID:31801617
The activating transcription factor 2: an influencer of cancer progression. PMID:31799611
Casein Kinase 1 Delta Regulates Cell Proliferation, Response to Chemotherapy and Migration in Human Ovarian Cancer Cells. PMID:31799185
Genomic alterations of Tenascin C in highly aggressive prostate cancer: a meta-analysis. PMID:31798767
Functional network analysis of gene-phenotype connectivity based on pioglitazone. PMID:31798704
Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression. PMID:31796516
Analysis of the Whole-Exome Sequencing of Tumor and Circulating Tumor DNA in Metastatic Melanoma. PMID:31795494
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. PMID:31792461
P63 modulates the expression of the WDFY2 gene which is implicated in cancer regulation and limb development. PMID:31789342
Identification of hub genes and key pathways associated with the progression of gynecological cancer. PMID:31788113
Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer. PMID:31788076
Bioinformatics analysis of Ewing's sarcoma: Seeking key candidate genes and pathways. PMID:31788075
A subset of patients with MSS/MSI-low-colorectal cancer showed increased CD8(+) TILs together with up-regulated IFN-γ. PMID:31788072
Five extracellular matrix-associated genes upregulated in oral tongue squamous cell carcinoma: An integrated bioinformatics analysis. PMID:31788070
Mutations in KIAA1109, CACNA1C, BSN, AKAP13, CELSR2, and HELZ2 Are Associated With the Prognosis in Endometrial Cancer. PMID:31787999
VISTA expression is associated with a favorable prognosis in patients with high-grade serous ovarian cancer. PMID:31781843
A stroma-corrected ZEB1 transcriptional signature is inversely associated with antitumor immune activity in breast cancer. PMID:31780722
Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma. PMID:31780666
Combined genetic mutations and DNA-methylated genes as biomarkers for endometrial cancer detection from cervical scrapings. PMID:31779688
β-HPV 8E6 Attenuates ATM and ATR Signaling in Response to UV Damage. PMID:31779191
Bioinformatics analysis reveals 6 key biomarkers associated with non-small-cell lung cancer. PMID:31775549
Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis. PMID:31775037
Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition. PMID:31772025
Screening and identification of key biomarkers in nasopharyngeal carcinoma: Evidence from bioinformatic analysis. PMID:31770211
Peroxisome proliferator-activated receptor gamma controls prostate cancer cell growth through AR-dependent and independent mechanisms. PMID:31769890
The Emerging Roles of ATP-Dependent Chromatin Remodeling Complexes in Pancreatic Cancer. PMID:31769422
Development and Characterization of a Genetic Mouse Model of KRAS Mutated Colorectal Cancer. PMID:31766149
Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing. PMID:31765373
Aberrant expression of embryonic mesendoderm factor MESP1 promotes tumorigenesis. PMID:31761621
Analysis of gene expression signatures identifies prognostic and functionally distinct ovarian clear cell carcinoma subtypes. PMID:31761620
Clinical outcomes of patients with POLE mutated endometrioid endometrial cancer. PMID:31757464
Emerging serine-threonine kinase inhibitors for treating ovarian cancer. PMID:31755325
OSacc: Gene Expression-Based Survival Analysis Web Tool For Adrenocortical Carcinoma. PMID:31749633
CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer. PMID:31747605
ATAD2 predicts poor outcomes in patients with ovarian cancer and is a marker of proliferation. PMID:31746426
Screening and identification of key biomarkers in prostate cancer using bioinformatics. PMID:31746380
Epidermal Growth Factor Receptor Mutations in Resectable Non-Small Cell Lung Cancer Patients and their Potential Role in the Immune Landscape. PMID:31746315
Response to Immunotherapy in Combination With Mitotane in Patients With Metastatic Adrenocortical Cancer. PMID:31745526
Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma. PMID:31744494
Systems analysis of barrier molecule and ARNT-related gene expression regulation in melanoma. PMID:31741768
Tumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer. PMID:31741762
High Tumor Mutation Burden and Other Immunotherapy Response Predictors in Breast Cancers: Associations and Therapeutic Opportunities. PMID:31741177
BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration. PMID:31740786
The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma. PMID:31739284
High expression of polo-like kinase 1 is associated with TP53 inactivation, DNA repair deficiency, and worse prognosis in ER positive Her2 negative breast cancer. PMID:31737202
Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity. PMID:31733993
RNA-binding protein NONO promotes breast cancer proliferation by post-transcriptional regulation of SKP2 and E2F8. PMID:31733123
Exploitation of CD133 for the Targeted Imaging of Lethal Prostate Cancer. PMID:31732520
Interleukin-18 Is a Prognostic Biomarker Correlated with CD8+ T Cell and Natural Killer Cell Infiltration in Skin Cutaneous Melanoma. PMID:31731729
Mutation-Driven Signals of ARID1A and PI3K Pathways in Ovarian Carcinomas: Alteration Is An Opportunity. PMID:31731647
Identification of key biomarkers associated with development and prognosis in patients with ovarian carcinoma: evidence from bioinformatic analysis. PMID:31729978
Late recurrence of breast cancer is associated with pro-cancerous immune microenvironment in the primary tumor. PMID:31729458
EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma. PMID:31727135
Significant association between high serum CCL5 levels and better disease-free survival of patients with early breast cancer. PMID:31724785
A gastric cancer LncRNAs model for MSI and survival prediction based on support vector machine. PMID:31722674
p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma. PMID:31720078
Cytokeratin 7-negative and GATA binding protein 3-negative breast cancers: Clinicopathological features and prognostic significance. PMID:31718619
Expression of Adenosine Receptors in Rodent Pancreas. PMID:31717704
Lipid Related Genes Altered in NASH Connect Inflammation in Liver Pathogenesis Progression to HCC: A Canonical Pathway. PMID:31717414
KRAS regulation by small non-coding RNAs and SNARE proteins. PMID:31712554
mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma. PMID:31712311
KRAS/NRAS/BRAF Mutations as Potential Targets in Multiple Myeloma. PMID:31709194
OCTANE (Ontario-wide Cancer Targeted Nucleic Acid Evaluation): a platform for intraprovincial, national, and international clinical data-sharing. PMID:31708655
OmicsARules: a R package for integration of multi-omics datasets via association rules mining. PMID:31703610
The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities. PMID:31703360
DriverDBv3: a multi-omics database for cancer driver gene research. PMID:31701128
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors. PMID:31699932
Copy number of 8q24.3 drives HSF1 expression and patient outcome in cancer: an individual patient data meta-analysis. PMID:31699156
Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade. PMID:31697821
Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data. PMID:31697689
A Multi-Element Expression Score Is A Prognostic Factor In Glioblastoma Multiforme. PMID:31695490
Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer. PMID:31695102
GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients. PMID:31694641
Characterization of HMGB1/2 Interactome in Prostate Cancer by Yeast Two Hybrid Approach: Potential Pathobiological Implications. PMID:31694235
TYK2: An Upstream Kinase of STATs in Cancer. PMID:31694222
The paracrine induction of prostate cancer progression by caveolin-1. PMID:31685812
Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability. PMID:31685811
Transcriptionally Active Androgen Receptor Splice Variants Promote Hepatocellular Carcinoma Progression. PMID:31685543
ER-Negative Breast Cancer Is Highly Responsive to Cholesterol Metabolite Signalling. PMID:31683867
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Mesothelioma With Bone Metastasis. PMID:31681739
LCTL Is a Prognostic Biomarker and Correlates With Stromal and Immune Infiltration in Gliomas. PMID:31681612
GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies. PMID:31681577
RAS: Striking at the Core of the Oncogenic Circuitry. PMID:31681559
Burden of rare exome sequence variants in PROC gene is associated with venous thromboembolism: a population-based study. PMID:31680443
Prognostic significance of KN motif and ankyrin repeat domains 1 (KANK1) in invasive breast cancer. PMID:31679074
High-resolution copy number analysis of clear cell endometrial carcinoma. PMID:31678638
Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer. PMID:31678591
HMGB1: an overview of its versatile roles in the pathogenesis of colorectal cancer. PMID:31677065
DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma. PMID:31676785
Synergistic apoptosis of human gastric cancer cells by bortezomib and TRAIL. PMID:31673231
Structure of the RSC complex bound to the nucleosome. PMID:31672915
Targeting Novel Sodium Iodide Symporter Interactors ADP-Ribosylation Factor 4 and Valosin-Containing Protein Enhances Radioiodine Uptake. PMID:31672844
Molecular Alterations in Thyroid Carcinoma. PMID:31672298
The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer. PMID:31666925
Genome-Wide Small RNA Sequencing Identifies MicroRNAs Deregulated in Non-Small Cell Lung Carcinoma Harboring Gain-of-Function Mutant p53. PMID:31661871
CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50. PMID:31660072
Landscape of Germline Mutations in DNA Repair Genes for Breast Cancer in Latin America: Opportunities for PARP-Like Inhibitors and Immunotherapy. PMID:31658756
Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration. PMID:31658270
PGC-1α inhibits polyamine metabolism in Cyclin E1-driven ovarian cancer. PMID:31657115
Increased expression of TET3 predicts unfavorable prognosis in patients with ovarian cancer-a bioinformatics integrative analysis. PMID:31656201
Overexpression of steroid sulfotransferase genes is associated with worsened prognosis and with immune exclusion in clear cell-renal cell carcinoma. PMID:31655797
Modulating cellular cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing. PMID:31653966
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression. PMID:31653849
PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9. PMID:31652979
High Expression of TTYH3 is Related to Poor Clinical Outcomes in Human Gastric Cancer. PMID:31652813
Lysyl oxidases: linking structures and immunity in the tumor microenvironment. PMID:31650200
ACTL6A regulates follicle-stimulating hormone-driven glycolysis in ovarian cancer cells via PGK1. PMID:31649264
Pathway Commons 2019 Update: integration, analysis and exploration of pathway data. PMID:31647099
Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors. PMID:31646100
Integrative analysis of genetic and epigenetic profiling of lung squamous cell carcinoma (LSCC) patients to identify smoking level relevant biomarkers. PMID:31641374
Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion. PMID:31641031
Exploiting ING2 Epigenetic Modulation as a Therapeutic Opportunity for Non-Small Cell Lung Cancer. PMID:31640185
PIAS1 is not suitable as a urothelial carcinoma biomarker protein and pharmacological target. PMID:31639157
β‑elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A‑VEGFA pathway based on network pharmacology. PMID:31638231
ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy. PMID:31636955
Oncometabolites in renal cancer. PMID:31636445
PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells. PMID:31636389
Mutational inactivation of mTORC1 repressor gene DEPDC5 in human gastrointestinal stromal tumors. PMID:31636198
ICOSLG-mediated regulatory T-cell expansion and IL-10 production promote progression of glioblastoma. PMID:31634400
Why Be One Protein When You Can Affect Many? The Multiple Roles of YB-1 in Lung Cancer and Mesothelioma. PMID:31632972
Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors. PMID:31632920
Antisense targeting of CD47 enhances human cytotoxic T-cell activity and increases survival of mice bearing B16 melanoma when combined with anti-CTLA4 and tumor irradiation. PMID:31628526
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia. PMID:31628323
CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation. PMID:31627350
Programmed Death Ligand 1 Indicates Pre-Existing Adaptive Immune Response by Tumor-Infiltrating CD8+ T Cells in Non-Small Cell Lung Cancer. PMID:31627272
Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers. PMID:31623662
Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma. PMID:31620242
Identification of prognostic biomarkers for malignant melanoma using microarray datasets. PMID:31620197
Prognostic Roles of Central Carbon Metabolism-Associated Genes in Patients With Low-Grade Glioma. PMID:31620163
NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis. PMID:31619256
Open-Sourced CIViC Annotation Pipeline to Identify and Annotate Clinically Relevant Variants Using Single-Molecule Molecular Inversion Probes. PMID:31618044
HOIL-1, an atypical E3 ligase that controls MyD88 signalling by forming ester bonds between ubiquitin and components of the Myddosome. PMID:31615747
Fast fluorescence in situ hybridisation for the enhanced detection of MET in non-small cell lung cancer. PMID:31613934
Identification of a Nine-Gene Signature and Establishment of a Prognostic Nomogram Predicting Overall Survival of Pancreatic Cancer. PMID:31612115
The Effects of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer-The Impact in Intratumoral Heterogeneity. PMID:31612112
Identification of candidate genes for the diagnosis and treatment of cholangiocarcinoma using a bioinformatics approach. PMID:31612054
Screening and identification of key biomarkers in lung squamous cell carcinoma by bioinformatics analysis. PMID:31612029
Evaluation of the target genes of arsenic trioxide in pancreatic cancer by bioinformatics analysis. PMID:31612027
Long non-coding RNA small nucleolar RNA host gene 7 is upregulated and promotes cell proliferation in thyroid cancer. PMID:31611982
Screening and identification of key biomarkers in adrenocortical carcinoma based on bioinformatics analysis. PMID:31611976
KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. PMID:31611389
Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells. PMID:31610800
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. PMID:31607565
A comprehensive expression landscape of RNA-binding proteins (RBPs) across 16 human cancer types. PMID:31607220
Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2. PMID:31605148
ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer. PMID:31604914
The Pan-Cancer Landscape of Coamplification of the Tyrosine Kinases KIT, KDR, and PDGFRA. PMID:31604903
Detection of Novel Fusion Transcript VTI1A-CFAP46 in Hepatocellular Carcinoma. PMID:31602373
A cellular and bioinformatics analysis of the SENP1 SUMO isopeptidase in pancreatic cancer. PMID:31602319
The great escape: tumour cell plasticity in resistance to targeted therapy. PMID:31601994
AEBP1 down regulation induced cell death pathway depends on PTEN status of glioma cells. PMID:31601918
miR2Diabetes: A Literature-Curated Database of microRNA Expression Patterns, in Diabetic Microvascular Complications. PMID:31601051
TFEB Expression Profiling in Renal Cell Carcinomas: Clinicopathologic Correlations. PMID:31600176
Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) overexpression in tumors predicts worse overall survival in hepatocellular carcinoma. PMID:31598161
Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines. PMID:31597922
Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma. PMID:31596908
PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies. PMID:31595832
A qualitative transcriptional signature for determining the grade of colorectal adenocarcinoma. PMID:31595030
Distinctive targetable genotypes of younger patients with lung adenocarcinoma: a cBioPortal for cancer genomics data base analysis. PMID:31594446
ADAM proteases: Emerging role and targeting of the non-catalytic domains. PMID:31593799
Outcomes of multimodal therapy in a large series of patients with anaplastic thyroid cancer. PMID:31593317
Integrative Molecular Analysis of Patients With Advanced and Metastatic Cancer. PMID:31592503
A rectal cancer organoid platform to study individual responses to chemoradiation. PMID:31591597
Bringing radiomics into a multi-omics framework for a comprehensive genotype-phenotype characterization of oncological diseases. PMID:31590671
Genetic modification of primary human B cells to model high-grade lymphoma. PMID:31586074
Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations. PMID:31585123
Diagnostic Utility of Next-Generation Sequencing for Disorders of Somatic Mosaicism: A Five-Year Cumulative Cohort. PMID:31585106
STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer. PMID:31581535
Clinical implications of ALDH1A1 and ALDH1A3 mRNA expression in melanoma subtypes. PMID:31580832
Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis. PMID:31576298
Bortezomib sensitivity is tissue dependent and high expression of the 20S proteasome precludes good response in malignant pleural mesothelioma. PMID:31576173
Pathway Mutations in Breast Cancer Using Whole-Exome Sequencing. PMID:31575382
iPSC-Derived Embryoid Bodies as Models of c-Met-Mutated Hereditary Papillary Renal Cell Carcinoma. PMID:31575031
Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer. PMID:31572453
UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma. PMID:31571992
Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53. PMID:31570706
A Shallow Convolutional Learning Network for Classification of Cancers Based on Copy Number Variations. PMID:31569801
Integration of Bioinformatics Resources Reveals the Therapeutic Benefits of Gemcitabine and Cell Cycle Intervention in SMAD4-Deleted Pancreatic Ductal Adenocarcinoma. PMID:31569425
FAT1, a direct transcriptional target of E2F1, suppresses cell proliferation, migration and invasion in esophageal squamous cell carcinoma. PMID:31564804
Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer. PMID:31562808
Molecular phenotyping using networks, diffusion, and topology: soft tissue sarcoma. PMID:31562358
Retinoid X receptor gamma (RXRG) is an independent prognostic biomarker in ER-positive invasive breast cancer. PMID:31558802
Targeting lysosome function causes selective cytotoxicity in VHL-inactivated renal cell carcinomas. PMID:31556451
Liquid biopsies using pleural effusion-derived exosomal DNA in advanced lung adenocarcinoma. PMID:31555514
Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing. PMID:31553912
Olfactory receptor gene abundance in invasive breast carcinoma. PMID:31551495
Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer. PMID:31551414
A systems mechanism for KRAS mutant allele-specific responses to targeted therapy. PMID:31551296
Mutation profiling of cancer drivers in Brazilian colorectal cancer. PMID:31548566
Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer. PMID:31548343
IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells. PMID:31548328
Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression. PMID:31548239
Chromosomal Density of Cancer Up-Regulated Genes, Aberrant Enhancer Activity and Cancer Fitness Genes Are Associated with Transcriptional Cis-Effects of Broad Copy Number Gains in Colorectal Cancer. PMID:31546890
Matched Whole-Genome Sequencing (WGS) and Whole-Exome Sequencing (WES) of Tumor Tissue with Circulating Tumor DNA (ctDNA) Analysis: Complementary Modalities in Clinical Practice. PMID:31546879
Programmed Death-Ligand 1 and Vimentin: A Tandem Marker as Prognostic Factor in NSCLC. PMID:31546725
Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma. PMID:31545501
In Silico Drug Prescription for Targeting Cancer Patient Heterogeneity and Prediction of Clinical Outcome. PMID:31540260
Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets. PMID:31537895
A conserved Bcd1 interaction essential for box C/D snoRNP biogenesis. PMID:31537647
Deciphering structure, function and mechanism of lysine acetyltransferase HBO1 in protein acetylation, transcription regulation, DNA replication and its oncogenic properties in cancer. PMID:31535175
Multi-view based integrative analysis of gene expression data for identifying biomarkers. PMID:31534156
A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1. PMID:31534152
Transcriptional alterations in glioma result primarily from DNA methylation-independent mechanisms. PMID:31533980
A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis. PMID:31533041
Robust and interpretable PAM50 reclassification exhibits survival advantage for myoepithelial and immune phenotypes. PMID:31531391
A FAM83A Positive Feed-back Loop Drives Survival and Tumorigenicity of Pancreatic Ductal Adenocarcinomas. PMID:31527715
High expression of bone morphogenetic protein (BMP) 6 and BMP7 are associated with higher immune cell infiltration and better survival in estrogen receptor‑positive breast cancer. PMID:31524275
HiLDA: a statistical approach to investigate differences in mutational signatures. PMID:31523512
Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer. PMID:31523393
ERBB3 mutations in cancer: biological aspects, prevalence and therapeutics. PMID:31519989
Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma. PMID:31519898
TOX3 is a favorable prognostic indicator and potential immunomodulatory factor in lung adenocarcinoma. PMID:31516613
Predictive value of pseudouridine in prostate cancer. PMID:31511832
SNRPB promotes the tumorigenic potential of NSCLC in part by regulating RAB26. PMID:31511502
CytoConverter: a web-based tool to convert karyotypes to genomic coordinates. PMID:31510921
Estimating the predictability of cancer evolution. PMID:31510665
PRECISE: a domain adaptation approach to transfer predictors of drug response from pre-clinical models to tumors. PMID:31510654
Combining ERBB family and MET inhibitors is an effective therapeutic strategy in cutaneous malignant melanoma independent of BRAF/NRAS mutation status. PMID:31506424
Ado-trastuzumab emtansine (T-DM1) in patients with HER2-amplified tumors excluding breast and gastric/gastroesophageal junction (GEJ) adenocarcinomas: results from the NCI-MATCH trial (EAY131) subprotocol Q. PMID:31504139
Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response. PMID:31501315
ESR1-Stabilizing Long Noncoding RNA TMPO-AS1 Promotes Hormone-Refractory Breast Cancer Progression. PMID:31501276
Precise Immunodetection of PTEN Protein in Human Neoplasia. PMID:31501265
Discovery of a new pyrimidine synthesis inhibitor eradicating glioblastoma-initiating cells. PMID:31499527
Lactoferrin CpG Island Hypermethylation and Decoupling of mRNA and Protein Expression in the Early Stages of Prostate Carcinogenesis. PMID:31499027
Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention? PMID:31496918
The relevance between the immune response-related gene module and clinical traits in head and neck squamous cell carcinoma. PMID:31496804
Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival. PMID:31492840
LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2. PMID:31492160
Function of low ADARB1 expression in lung adenocarcinoma. PMID:31491024
Docking-based approach for identification of mutations that disrupt binding between Bcl-2 and Bax proteins: Inducing apoptosis in cancer cells. PMID:31490001
Tumor-induced peripheral immunosuppression promotes brain metastasis in patients with non-small cell lung cancer. PMID:31489465
Bioinformatic evidences and analysis of putative biomarkers in pancreatic ductal adenocarcinoma. PMID:31489384
USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation. PMID:31488580
Regulation of histone methylation by automethylation of PRC2. PMID:31488576
CFHR1 is a potentially downregulated gene in lung adenocarcinoma. PMID:31485643
Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis. PMID:31483918
Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. PMID:31483290
Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells. PMID:31481733
ATMIN Is a Tumor Suppressor Gene in Lung Adenocarcinoma. PMID:31481498
Ceritinib-Induced Regression of an Insulin-Like Growth Factor-Driven Neuroepithelial Brain Tumor. PMID:31480400
High Proportion of Potential Candidates for Immunotherapy in a Chilean Cohort of Gastric Cancer Patients: Results of the FORCE1 Study. PMID:31480291
Tumor-Derived Peptidoglycan Recognition Protein 2 Predicts Survival and Antitumor Immune Responses in Hepatocellular Carcinoma. PMID:31479523
Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro. PMID:31477700
Identification and validation of a prognostic proteomic signature for cervical cancer. PMID:31477280
The Dual Roles of the Atypical Protein Kinase Cs in Cancer. PMID:31474570
Annexin A8 can serve as potential prognostic biomarker and therapeutic target for ovarian cancer: based on the comprehensive analysis of Annexins. PMID:31474227
Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data. PMID:31472672
Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression. PMID:31471524
Frequency and outcomes of brain metastases in patients with HER2-mutant lung cancers. PMID:31469421
Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl-xL inhibition. PMID:31468706
ERK1/2 signaling regulates the immune microenvironment and macrophage recruitment in glioblastoma. PMID:31467175
Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies. PMID:31467060
BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain Tumors. PMID:31466300
MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues. PMID:31466240
Coxsackievirus Type B3 Is a Potent Oncolytic Virus against KRAS-Mutant Lung Adenocarcinoma. PMID:31463367
BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer. PMID:31462713
WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. PMID:31462314
Telomere alterations in neurofibromatosis type 1-associated solid tumors. PMID:31462295
Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma. PMID:31462277
Characterizing the Binding Interactions between DNA-Binding Proteins, XPA and XPE: A Molecular Dynamics Approach. PMID:31458200
PIDD interaction with KEAP1 as a new mutation-independent mechanism to promote NRF2 stabilization and chemoresistance in NSCLC. PMID:31455821
Analysis of Tumor Genomic Pathway Alterations Using Broad-Panel Next-Generation Sequencing in Surgically Resected Lung Adenocarcinoma. PMID:31455678
Alzheimer's Disease Susceptibility Genes in Malignant Breast Tumors. PMID:31453369
V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss. PMID:31452834
High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis. PMID:31452794
An integrated bioinformatics analysis of potential therapeutic targets among matrix metalloproteinases in breast cancer. PMID:31452777
Screening and identification of potential target genes in head and neck cancer using bioinformatics analysis. PMID:31452775
Multi-kinase inhibitors and cisplatin for head and neck cancer treatment in vitro. PMID:31452723
How Many Papillae in Conventional Papillary Carcinoma? A Clinical Evidence-Based Pathology Study of 235 Unifocal Encapsulated Papillary Thyroid Carcinomas, with Emphasis on the Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features. PMID:31452453
Transcriptomic Analysis Identifies RNA Binding Proteins as Putative Regulators of Myelopoiesis and Leukemia. PMID:31448224
Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma. PMID:31446433
Genomic Landscape and Immune Microenvironment Features of Preinvasive and Early Invasive Lung Adenocarcinoma. PMID:31446140
A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma. PMID:31444368
GPR56 Drives Colorectal Tumor Growth and Promotes Drug Resistance through Upregulation of MDR1 Expression via a RhoA-Mediated Mechanism. PMID:31444231
Determining the prognostic significance of alternative splicing events in soft tissue sarcoma using data from The Cancer Genome Atlas. PMID:31443718
For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors. PMID:31443495
The Prognosis Value of PIWIL1 and PIWIL2 Expression in Pancreatic Cancer. PMID:31443431
High expression of the vacuole membrane protein 1 (VMP1) is a potential marker of poor prognosis in HER2 positive breast cancer. PMID:31442252
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. PMID:31439867
Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination. PMID:31437751
Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia. PMID:31436048
Chronic iron exposure and c-Myc/H-ras-mediated transformation in fallopian tube cells alter the expression of EVI1, amplified at 3q26.2 in ovarian cancer. PMID:31434871
Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming. PMID:31433975
tRic: a user-friendly data portal to explore the expression landscape of tRNAs in human cancers. PMID:31432762
Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma. PMID:31431454
Parkin gene mutations are not common, but its epigenetic inactivation is a frequent event and predicts poor survival in advanced breast cancer patients. PMID:31429726
Impact of KRAS and TP53 Co-Mutations on Outcomes After First-Line Systemic Therapy Among Patients With STK11-Mutated Advanced Non-Small-Cell Lung Cancer. PMID:31428721
LSD1 Activates PI3K/AKT Signaling Through Regulating p85 Expression in Prostate Cancer Cells. PMID:31428587
Circulating Tumor DNA Sequencing Analysis of Gastroesophageal Adenocarcinoma. PMID:31427281
E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition. PMID:31424118
Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer. PMID:31423895
Long noncoding RNA LINC01089 predicts clinical prognosis and inhibits cell proliferation and invasion through the Wnt/β-catenin signaling pathway in breast cancer. PMID:31417284
MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21. PMID:31413145
Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression. PMID:31411736
DNA polymerase ζ in DNA replication and repair. PMID:31410467
New CXCR1/CXCR2 inhibitors represent an effective treatment for kidney or head and neck cancers sensitive or refractory to reference treatments. PMID:31410218
The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation. PMID:31409643
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. PMID:31408619
The role of Ki-67 in Asian triple negative breast cancers: a novel combinatory panel approach. PMID:31407032
Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy. PMID:31406302
Integration of Radiomic and Multi-omic Analyses Predicts Survival of Newly Diagnosed IDH1 Wild-Type Glioblastoma. PMID:31405148
Integrative Analysis of Cancer Omics Data for Prognosis Modeling. PMID:31405076
KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment. PMID:31404541
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer. PMID:31404287
Comprehensive analysis of peroxiredoxins expression profiles and prognostic values in breast cancer. PMID:31402980
Mechanical Stabilization of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex. PMID:31402305
Inactivation of Wild-Type p53 by Asparagine Endopeptidase in Glioblastoma: An Opportunity to Target the "Undruggable". PMID:31400198
Heterocellular gene signatures reveal luminal-A breast cancer heterogeneity and differential therapeutic responses. PMID:31396557
Prognostic alternative splicing signatures and underlying regulatory network in esophageal carcinoma. PMID:31396315
Proteogenomic landscape of squamous cell lung cancer. PMID:31395880
ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis. PMID:31395079
Identification of significant gene and pathways involved in HBV-related hepatocellular carcinoma by bioinformatics analysis. PMID:31392101
LINC00346 promotes pancreatic cancer progression through the CTCF-mediated Myc transcription. PMID:31391552
ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion. PMID:31391455
Lasting DNA Damage and Aberrant DNA Repair Gene Expression Profile Are Associated with Post-Chronic Cadmium Exposure in Human Bronchial Epithelial Cells. PMID:31390735
A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras Activation. PMID:31390566
Genomic and clinical characterization of pulmonary-only metastatic prostate cancer: A unique molecular subtype. PMID:31389628
Cyclin-dependent kinase inhibitor 2B gene is associated with the sensitivity of hepatoma cells to Sorafenib. PMID:31388306
Identification and Clinical Validation of a Novel 4 Gene-Signature with Prognostic Utility in Colorectal Cancer. PMID:31387239
CpG promoter hypo-methylation and up-regulation of microRNA-190b in hormone receptor-positive breast cancer. PMID:31384394
Characterization of the prognostic values of the NDRG family in gastric cancer. PMID:31384305
Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers. PMID:31383035
Evaluation of MT Family Isoforms as Potential Biomarker for Predicting Progression and Prognosis in Gastric Cancer. PMID:31380415
Survival Analysis of Multi-Omics Data Identifies Potential Prognostic Markers of Pancreatic Ductal Adenocarcinoma. PMID:31379917
Prognostic Significance of Potential Immune Checkpoint Member HHLA2 in Human Tumors: A Comprehensive Analysis. PMID:31379814
C-Jun drives melanoma progression in PTEN wild type melanoma cells. PMID:31378787
Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition. PMID:31378590
Differential gene expression analysis reveals novel genes and pathways in pediatric septic shock patients. PMID:31375728
Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability. PMID:31374965
Association of C8orf4 expression with its methylation status, aberrant β-catenin expression, and the development of cervical squamous cell carcinoma. PMID:31374065
Clinical Implications of Chromosomal Instability (CIN) and Kinetochore Abnormalities in Breast Cancers. PMID:31372940
The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression. PMID:31372497
Long non-coding RNA MIAT promotes papillary thyroid cancer progression through upregulating LASP1. PMID:31372094
Prognostic roles of the transcriptional expression of exportins in hepatocellular carcinoma. PMID:31371628
Clinical and preclinical characterization of CD99 isoforms in acute myeloid leukemia. PMID:31371417
BRN4 Is a Novel Driver of Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer and Is Selectively Released in Extracellular Vesicles with BRN2. PMID:31371344
Claudin-low-like mouse mammary tumors show distinct transcriptomic patterns uncoupled from genomic drivers. PMID:31366361
TP53 DNA Binding Domain Mutations Predict Progression-Free Survival of Bevacizumab Therapy in Metastatic Colorectal Cancer. PMID:31366114
Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas. PMID:31365877
Detailed modeling of positive selection improves detection of cancer driver genes. PMID:31363082
Genome atlas analysis based profiling of Akt pathway genes in the early and advanced human prostate cancer. PMID:31360736
CDK12 inactivation across solid tumors: an actionable genetic subtype. PMID:31360735
The landscape of novel and complementary targets for immunotherapy: an analysis of gene expression in the tumor microenvironment. PMID:31360302
Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project. PMID:31357599
A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis. PMID:31357169
m1A Regulated Genes Modulate PI3K/AKT/mTOR and ErbB Pathways in Gastrointestinal Cancer. PMID:31352195
Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome instability. PMID:31350889
Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer. PMID:31350446
Establishing a prognostic threshold for total copy number variation within adult IDH-mutant grade II/III astrocytomas. PMID:31349875
Oncogenic effect of PHLDB2 is associated with epithelial-mesenchymal transition and E-cadherin regulation in colorectal cancer. PMID:31346319
Systematic analysis of the intersection of disease mutations with protein modifications. PMID:31345222
Prognostic nomogram based on immune scores for breast cancer patients. PMID:31342666
In Vivo Assessment of VCAM-1 Expression by SPECT/CT Imaging in Mice Models of Human Triple Negative Breast Cancer. PMID:31340603
Molecular Mechanisms of p63-Mediated Squamous Cancer Pathogenesis. PMID:31340447
The molecular genetic make-up of male breast cancer. PMID:31340200
Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer. PMID:31340155
Prognostic Score Predicts Survival in HPV-Negative Head and Neck Squamous Cell Cancer Patients. PMID:31337965
SCF(FBXW7)-mediated degradation of p53 promotes cell recovery after UV-induced DNA damage. PMID:31337255
Multi-omic Dissection of Oncogenically Active Epiproteomes Identifies Drivers of Proliferative and Invasive Breast Tumors. PMID:31336272
The Cajal Body Protein WRAP53β Prepares the Scene for Repair of DNA Double-Strand Breaks by Regulating Local Ubiquitination. PMID:31334247
Upregulation of nucleoprotein AHNAK is associated with poor outcome of pancreatic ductal adenocarcinoma prognosis via mediating epithelial-mesenchymal transition. PMID:31333803
Combined Photosensitization and Vaccination Enable CD8 T-Cell Immunity and Tumor Suppression Independent of CD4 T-Cell Help. PMID:31333674
Transcriptome profiling-based identification of prognostic subtypes and multi-omics signatures of glioblastoma. PMID:31332251
Functional genomics identifies predictive markers and clinically actionable resistance mechanisms to CDK4/6 inhibition in bladder cancer. PMID:31331377
Emerging Therapeutic Opportunities Based on Current Knowledge of Uveal Melanoma Biology. PMID:31330784
Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy. PMID:31330086
Targeting PDZ-binding kinase is anti-tumorigenic in novel preclinical models of ACC. PMID:31325906
Bioinformatics-based discovery of PYGM and TNNC2 as potential biomarkers of head and neck squamous cell carcinoma. PMID:31324732
Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer. PMID:31324173
Identification of a key candidate gene‑phenotype network mediated by glycyrrhizic acid using pharmacogenomic analysis. PMID:31322195
Identification of important invasion and proliferation related genes in adrenocortical carcinoma. PMID:31321566
NSD1 mutations by HPV status in head and neck cancer: differences in survival and response to DNA-damaging agents. PMID:31321084
FGFR3S249C mutation promotes chemoresistance by activating Akt signaling in bladder cancer cells. PMID:31316618
SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait. PMID:31316083
Oncolytic Maraba virus armed with tumor antigen boosts vaccine priming and reveals diverse therapeutic response patterns when combined with checkpoint blockade in ovarian cancer. PMID:31315674
GCN-5/PGC-1α signaling is activated and associated with metabolism in cyclin E1-driven ovarian cancer. PMID:31313989
Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer. PMID:31312514
PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization. PMID:31311869
Exploring the Molecular Mechanism of the Drug-Treated Breast Cancer Based on Gene Expression Microarray. PMID:31311202
Molecular prognosticators in clinically and pathologically distinct cohorts of head and neck squamous cell carcinoma-A meta-analysis approach. PMID:31310629
Rgnef promotes ovarian tumor progression and confers protection from oxidative stress. PMID:31308489
Integration and Analysis of CPTAC Proteomics Data in the Context of Cancer Genomics in the cBioPortal. PMID:31308250
Next-generation RNA sequencing of FFPE subsections reveals highly conserved stromal reprogramming between canine and human mammary carcinoma. PMID:31308057
APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC. PMID:31307523
CEMIP upregulates BiP to promote breast cancer cell survival in hypoxia. PMID:31303964
Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. PMID:31303424
The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease. PMID:31302748
CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes. PMID:31300537
Circulating Tumor DNA Profiling in Small-Cell Lung Cancer Identifies Potentially Targetable Alterations. PMID:31300452
XPNPEP2 is associated with lymph node metastasis in prostate cancer patients. PMID:31296901
GENT2: an updated gene expression database for normal and tumor tissues. PMID:31296229
CONFIGURE: A pipeline for identifying context specific regulatory modules from gene expression data and its application to breast cancer. PMID:31296219
CoMutPlotter: a web tool for visual summary of mutations in cancer cohorts. PMID:31296206
Inhibition of Phosphatidylinositol 3-kinase (PI3K) Signaling Synergistically Potentiates Antitumor Efficacy of Paclitaxel and Overcomes Paclitaxel-Mediated Resistance in Cervical Cancer. PMID:31295843
HeartBioPortal. PMID:31294639
Emergence of ERBB2 Mutation as a Biomarker and an Actionable Target in Solid Cancers. PMID:31292270
Characterizing responsive and refractory orthotopic mouse models of hepatocellular carcinoma in cancer immunotherapy. PMID:31291357
MicroRNA-410-3p upregulation suppresses proliferation, invasion and migration, and promotes apoptosis in rhabdomyosarcoma cells. PMID:31289572
DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer. PMID:31289523
Molecular and histopathology directed therapy for advanced bladder cancer. PMID:31289379
The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde? †. PMID:31288625
mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer. PMID:31288154
Stability and sub-cellular localization of DNA polymerase β is regulated by interactions with NQO1 and XRCC1 in response to oxidative stress. PMID:31287140
The Role of APAL/ST8SIA6-AS1 lncRNA in PLK1 Activation and Mitotic Catastrophe of Tumor Cells. PMID:31286138
A functional genetic screen defines the AKT-induced senescence signaling network. PMID:31285545
FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation. PMID:31285543
Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics. PMID:31284662
miR-340-5p Suppresses Aggressiveness in Glioblastoma Multiforme by Targeting Bcl-w and Sox2. PMID:31272074
Pembrolizumab in men with heavily treated metastatic castrate-resistant prostate cancer. PMID:31270961
SOX4 regulates invasion of bladder cancer cells via repression of WNT5a. PMID:31268162
Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma. PMID:31266951
Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments. PMID:31263265
CD97 expression is associated with poor overall survival in acute myeloid leukemia. PMID:31260716
Loss of function Cbl-c mutations in solid tumors. PMID:31260484
Clustered microRNAs hsa-miR-221-3p/hsa-miR-222-3p and their targeted genes might be prognostic predictors for hepatocellular carcinoma. PMID:31258758
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling. PMID:31253801
Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma. PMID:31252679
Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review. PMID:31249452
FGFR2-Altered Gastroesophageal Adenocarcinomas Are an Uncommon Clinicopathologic Entity with a Distinct Genomic Landscape. PMID:31249137
Integration of Random Forest Classifiers and Deep Convolutional Neural Networks for Classification and Biomolecular Modeling of Cancer Driver Mutations. PMID:31245384
A tropomyosin receptor kinase family protein, NTRK2 is a potential predictive biomarker for lung adenocarcinoma. PMID:31245181
A liver-specific lncRNA, FAM99B, suppresses hepatocellular carcinoma progression through inhibition of cell proliferation, migration, and invasion. PMID:31243545
FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. PMID:31243370
Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer. PMID:31243151
Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics. PMID:31243108
Parallel-Reaction-Monitoring-Based Proteome-Wide Profiling of Differential Kinase Protein Expression during Prostate Cancer Metastasis in Vitro. PMID:31241916
Direct Ras G12C inhibitors: crossing the rubicon. PMID:31239544
KLF4 as a rheostat of osteolysis and osteogenesis in prostate tumors in the bone. PMID:31239516
Anticancer Effects of Emodin on HepG2 Cell: Evidence from Bioinformatic Analysis. PMID:31236404
The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression. PMID:31235595
ASC-J9® increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-κB survival signals. PMID:31234917
Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas. PMID:31231471
Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications. PMID:31231212
Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype. PMID:31230251
Concurrent RB1 and TP53 Alterations Define a Subset of EGFR-Mutant Lung Cancers at risk for Histologic Transformation and Inferior Clinical Outcomes. PMID:31228622
Methylation-associated miR-193b silencing activates master drivers of aggressive prostate cancer. PMID:31225930
ATRX Mutations in Pineal Parenchymal Tumors of Intermediate Differentiation. PMID:31225581
Amplification of lncRNA PVT1 promotes ovarian cancer proliferation by binding to miR-140. PMID:31222482
The chromatin remodeler Chd1 regulates cohesin in budding yeast and humans. PMID:31222142
The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation. PMID:31221779
Systems-level Analysis Reveals Multiple Modulators of Epithelial-mesenchymal Transition and Identifies DNAJB4 and CD81 as Novel Metastasis Inducers in Breast Cancer. PMID:31221721
A subtype of oral, laryngeal, esophageal, and lung, squamous cell carcinoma with high levels of TrkB-T1 neurotrophin receptor mRNA. PMID:31221127
GATA3 Truncating Mutations Promote Cistromic Re-Programming In Vitro, but Not Mammary Tumor Formation in Mice. PMID:31218575
Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes. PMID:31217899
ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells. PMID:31217031
TP53 structural variants in metastatic prostatic carcinoma. PMID:31216325
TuBA: Tunable biclustering algorithm reveals clinically relevant tumor transcriptional profiles in breast cancer. PMID:31216036
Distribution differences in prognostic copy number alteration profiles in IDH-wild-type glioblastoma cause survival discrepancies across cohorts. PMID:31215469
Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer. PMID:31215437
PP2A: A Promising Biomarker and Therapeutic Target in Endometrial Cancer. PMID:31214504
Revisiting Non-BRCA1/2 Familial Whole Exome Sequencing Datasets Implicates NCK1 as a Cancer Gene. PMID:31214250
Expressions of HLA Class II Genes in Cutaneous Melanoma Were Associated with Clinical Outcome: Bioinformatics Approaches and Systematic Analysis of Public Microarray and RNA-Seq Datasets. PMID:31212865
Survival analysis and functional annotation of long non-coding RNAs in lung adenocarcinoma. PMID:31211495
The potential markers of endocrine resistance among HR+ /HER2+ breast cancer patients. PMID:31209793
FAM84B promotes prostate tumorigenesis through a network alteration. PMID:31205500
Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer. PMID:31201273
NF1 mutations identify molecular and clinical subtypes of lung adenocarcinomas. PMID:31199580
Aberrantly expressed PLOD1 promotes cancer aggressiveness in bladder cancer: a potential prognostic marker and therapeutic target. PMID:31199049
ALDH1A3-regulated long non-coding RNA NRAD1 is a potential novel target for triple-negative breast tumors and cancer stem cells. PMID:31197235
The ion channels and transporters gene expression profile indicates a shift in excitability and metabolisms during malignant progression of Follicular Lymphoma. PMID:31197180
CK2 Pro-Survival Role in Prostate Cancer Is Mediated via Maintenance and Promotion of Androgen Receptor and NFκB p65 Expression. PMID:31197122
Loss of Fbxw7 synergizes with activated Akt signaling to promote c-Myc dependent cholangiocarcinogenesis. PMID:31195063
Two factor authentication: Asf1 mediates crosstalk between H3 K14 and K56 acetylation. PMID:31194870
Identification of novel biomarkers and candidate small molecule drugs in non-small-cell lung cancer by integrated microarray analysis. PMID:31190860
Overexpression of NCAPH is upregulated and predicts a poor prognosis in prostate cancer. PMID:31186803
NOTCH2/NOTCH3/DLL3/MAML1/ADAM17 signaling network is associated with ovarian cancer. PMID:31186700
Differential Expression Profile of NLRs and AIM2 in Glioma and Implications for NLRP12 in Glioblastoma. PMID:31186453
Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence. PMID:31186408
AXL Is a Novel Predictive Factor and Therapeutic Target for Radioactive Iodine Refractory Thyroid Cancer. PMID:31181609
PLEKHO1 knockdown inhibits RCC cell viability in vitro and in vivo, potentially by the Hippo and MAPK/JNK pathways. PMID:31180521
Identification of Specific Lysines and Arginines That Mediate Angiomotin Membrane Association. PMID:31179409
Total copy number variation as a prognostic factor in adult astrocytoma subtypes. PMID:31177992
Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations. PMID:31175097
Identification of key candidate genes involved in melanoma metastasis. PMID:31173190
Carbonic anhydrases as disease markers. PMID:31172829
Illuminating the Onco-GPCRome: Novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy. PMID:31171722
High expression of Annexin A2 is associated with DNA repair, metabolic alteration, and worse survival in pancreatic ductal adenocarcinoma. PMID:31171367
PROM1 and PROM2 expression differentially modulates clinical prognosis of cancer: a multiomics analysis. PMID:31164716
Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition. PMID:31158244
RHOA in Gastric Cancer: Functional Roles and Therapeutic Potential. PMID:31156701
Characterization of upregulated adhesion GPCRs in acute myeloid leukemia. PMID:31153896
Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma. PMID:31151416
High OGT activity is essential for MYC-driven proliferation of prostate cancer cells. PMID:31149037
MicroRNA-335/ID4 dysregulation predicts clinical outcome and facilitates leukemogenesis by activating PI3K/Akt signaling pathway in acute myeloid leukemia. PMID:31147526
Novel secretome-to-transcriptome integrated or secreto-transcriptomic approach to reveal liquid biopsy biomarkers for predicting individualized prognosis of breast cancer patients. PMID:31146747
Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway. PMID:31146385
Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility. PMID:31142743
RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme. PMID:31142741
The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis. PMID:31142515
Defining molecular risk in ALK+ NSCLC. PMID:31139322
Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma. PMID:31139015
RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression. PMID:31138663
Identification of Crucial Candidate Genes and Pathways in Glioblastoma Multiform by Bioinformatics Analysis. PMID:31137733
Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer. PMID:31137727
ROR1 Potentiates FGFR Signaling in Basal-Like Breast Cancer. PMID:31137681
A Novel Set of WNT Pathway Effectors as a Predictive Marker of Uterine Corpus Endometrial Carcinoma-Study Based on Weighted Co-expression Matrices. PMID:31134156
Identification of Hub Genes Associated With Progression and Prognosis in Patients With Bladder Cancer. PMID:31134129
Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis. PMID:31133044
Genetic Alterations Detected in Cell-Free DNA Are Associated With Enzalutamide and Abiraterone Resistance in Castration-Resistant Prostate Cancer. PMID:31131348
COMPASS Ascending: Emerging clues regarding the roles of MLL3/KMT2C and MLL2/KMT2D proteins in cancer. PMID:31128216
Tumor-associated antigens identified early in mouse mammary tumor development can be effective vaccine targets. PMID:31126858
Genomic Characterization of Prostatic Ductal Adenocarcinoma Identifies a High Prevalence of DNA Repair Gene Mutations. PMID:31123724
Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression. PMID:31123087
Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer. PMID:31122207
The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21. PMID:31116991
Neuroblastoma RAS viral oncogene homolog mRNA is differentially spliced to give five distinct isoforms: implications for melanoma therapy. PMID:31116161
MEXPRESS update 2019. PMID:31114869
Combining the Specific Anti-MUC1 Antibody TAB004 and Lip-MSA-IL-2 Limits Pancreatic Cancer Progression in Immune Competent Murine Models of Pancreatic Ductal Adenocarcinoma. PMID:31114758
Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma. PMID:31114500
FAM111B, a direct target of p53, promotes the malignant process of lung adenocarcinoma. PMID:31114230
A key genomic subtype associated with lymphovascular invasion in invasive breast cancer. PMID:31114020
BRD4 Regulates Metastatic Potential of Castration-Resistant Prostate Cancer through AHNAK. PMID:31110158
Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer. PMID:31107239
Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets. PMID:31105872
Genomic landscape analyses of reprogrammed cells using integrative and non-integrative methods reveal variable cancer-associated alterations. PMID:31105870
APPBP2 enhances non-small cell lung cancer proliferation and invasiveness through regulating PPM1D and SPOP. PMID:31105033
LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML. PMID:31105032
Low expression of WWC1, a tumor suppressor gene, is associated with aggressive breast cancer and poor survival outcome. PMID:31102318
Loss of Disabled-2 Expression in Pancreatic Cancer Progression. PMID:31101868
Heat shock proteins create a signature to predict the clinical outcome in breast cancer. PMID:31101846
The LIM protein Ajuba/SP1 complex forms a feed forward loop to induce SP1 target genes and promote pancreatic cancer cell proliferation. PMID:31101117
Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening. PMID:31097696
c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma. PMID:31097685
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. PMID:31097636
Mining and validating the expression pattern and prognostic value of acetylcholine receptors in non-small cell lung cancer. PMID:31096457
Allelic Switching of DLX5, GRB10, and SVOPL during Colorectal Cancer Tumorigenesis. PMID:31093489
The cylindromatosis (CYLD) gene and head and neck tumorigenesis. PMID:31093340
Prognostic Value of BIRC5 in Lung Adenocarcinoma Lacking EGFR, KRAS, and ALK Mutations by Integrated Bioinformatics Analysis. PMID:31093306
Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis. PMID:31093284
Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data. PMID:31092827
Titin mutation associated with responsiveness to checkpoint blockades in solid tumors. PMID:31092729
In silico prediction of housekeeping long intergenic non-coding RNAs reveals HKlincR1 as an essential player in lung cancer cell survival. PMID:31089191
JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression. PMID:31089135
Radiation-Induced DNA Damage Cooperates with Heterozygosity of TP53 and PTEN to Generate High-Grade Gliomas. PMID:31088835
Identification of novel biomarkers and small molecule drugs in human colorectal cancer by microarray and bioinformatics analysis. PMID:31087508
Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling. PMID:31087223
FANCD2 Binding to H4K20me2 via a Methyl-Binding Domain Is Essential for Efficient DNA Cross-Link Repair. PMID:31085681
The dynamic conformational landscape of the protein methyltransferase SETD8. PMID:31081496
INKA2, a novel p53 target that interacts with the serine/threonine kinase PAK4. PMID:31081062
Phospho‑STAT1 expression as a potential biomarker for anti‑PD‑1/anti‑PD‑L1 immunotherapy for breast cancer. PMID:31081058
Hyper-O-GlcNAcylation promotes epithelial-mesenchymal transition in endometrial cancer cells. PMID:31080560
Mutation profiles of follicular thyroid tumors by targeted sequencing. PMID:31077238
Generalized gene co-expression analysis via subspace clustering using low-rank representation. PMID:31074376
USP9X-mediated deubiquitination of B-cell CLL/lymphoma 9 potentiates Wnt signaling and promotes breast carcinogenesis. PMID:31073027
Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity. PMID:31072879
Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer. PMID:31072371
Graphical data mining of cancer mechanisms with SEMA. PMID:31070723
Focal Adhesion Kinase and β-Catenin Cooperate to Induce Hepatocellular Carcinoma. PMID:31069844
WISP1 is associated to advanced disease, EMT and an inflamed tumor microenvironment in multiple solid tumors. PMID:31069142
Gelsolin-like actin-capping protein has prognostic value and promotes tumorigenesis and epithelial-mesenchymal transition via the Hippo signaling pathway in human bladder cancer. PMID:31068979
Next-generation characterization of the Cancer Cell Line Encyclopedia. PMID:31068700
A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1. PMID:31068365
[Citron Rho-interacting serine/threonine kinase knockdown suppresses prostate cancer cell proliferation and metastasis by blocking Hippo-YAP pathway]. PMID:31068310
The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer. PMID:31067569
Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition. PMID:31064120
Anchorage-independent growth conditions reveal a differential SOS2 dependence for transformation and survival in RAS-mutant cancer cells. PMID:31062644
von Willebrand Factor Gene Expression in Primary Lower Grade Glioma: Mutually Co-Occurring Mutations in von Willebrand Factor, ATRX, and TP53. PMID:31062529
Targeting the High-Mobility Group Box 3 Protein Sensitizes Chemoresistant Ovarian Cancer Cells to Cisplatin. PMID:31061066
Expression and prognostic value of NSD1 and SETD2 in pancreatic ductal adenocarcinoma and its precursor lesions. PMID:31060750
A TMEFF2-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer. PMID:31060542
Genomic Profiling of the Steroidogenic Acute Regulatory Protein in Breast Cancer: In Silico Assessments and a Mechanistic Perspective. PMID:31060224
Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy. PMID:31059199
Prospective molecular mechanism of COL5A1 in breast cancer based on a microarray, RNA sequencing and immunohistochemistry. PMID:31059074
Five miRNAs-mediated PIEZO2 downregulation, accompanied with activation of Hedgehog signaling pathway, predicts poor prognosis of breast cancer. PMID:31058608
Molecular Pathogenesis of Gene Regulation by the miR-150 Duplex: miR-150-3p Regulates TNS4 in Lung Adenocarcinoma. PMID:31052206
HDAC5 Expression in Urothelial Carcinoma Cell Lines Inhibits Long-Term Proliferation but Can Promote Epithelial-to-Mesenchymal Transition. PMID:31052182
PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt/β-catenin signaling pathway. PMID:31043858
Prognostic role of ARID1A negative expression in gastric cancer. PMID:31043675
SNW1 is a prognostic biomarker in prostate cancer. PMID:31043167
Exome Sequencing of a Primary Ovarian Insufficiency Cohort Reveals Common Molecular Etiologies for a Spectrum of Disease. PMID:31042289
The multiple roles of the unfolded protein response regulator IRE1α in cancer. PMID:31041814
Loss of Tyrosine Phosphatase Delta Promotes Gastric Cancer Progression via Signal Transducer and Activator of Transcription 3 Pathways. PMID:31041642
Inferring cancer dependencies on metabolic genes from large-scale genetic screens. PMID:31039782
[Detection and interpretation of somatic variants in molecular pathology]. PMID:31037375
Downregulation of CYB5D2 is associated with breast cancer progression. PMID:31036830
Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer. PMID:31036156
PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma. PMID:31036078
Clinico-pathological associations and concomitant mutations of the RAS/RAF pathway in metastatic colorectal cancer. PMID:31036005
Finding driver mutations in cancer: Elucidating the role of background mutational processes. PMID:31034466
Aberrant Rac pathway signalling in glioblastoma. PMID:31032735
Whole exome sequencing reveals mutations in FAT1 tumor suppressor gene clinically impacting on peripheral T-cell lymphoma not otherwise specified. PMID:31028364
RAC1 Takes the Lead in Solid Tumors. PMID:31027363
Differential Activation of ERK Signaling in HPV-Related Oropharyngeal Squamous Cell Carcinoma. PMID:31027243
UNR/CSDE1 Expression Is Critical to Maintain Invasive Phenotype of Colorectal Cancer through Regulation of c-MYC and Epithelial-to-Mesenchymal Transition. PMID:31027221
BRCA1 mRNA expression modifies the effect of T cell activation score on patient survival in breast cancer. PMID:31023256
Inducible expression of immediate early genes is regulated through dynamic chromatin association by NF45/ILF2 and NF90/NF110/ILF3. PMID:31022259
Complicated prognostic values of CCL28 in breast cancer by subtype. PMID:31019765
Increased RNA Expression of von Willebrand Factor Gene Is Associated With Infiltrating Lobular Breast Cancer and Normal PAM50 Subtype. PMID:31018945
In silico learning of tumor evolution through mutational time series. PMID:31015295
MicroRNA-92 Expression in CD133+ Melanoma Stem Cells Regulates Immunosuppression in the Tumor Microenvironment via Integrin-Dependent Activation of TGFβ. PMID:31015227
Long Non-Coding RNA ZFAS1 as a Novel Potential Biomarker for Predicting the Prognosis of Thyroid Cancer. PMID:31012438
Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer. PMID:31010205
Oncogenic Role of ZFAS1 lncRNA in Head and Neck Squamous Cell Carcinomas. PMID:31010087
Dual inhibition of ABCE1 and LCP1 by microRNA-96 results in an additive effect in breast cancer mouse model. PMID:31007850
Cancer Genetic Network Inference Using Gaussian Graphical Models. PMID:31007526
An SH3PX1-Dependent Endocytosis-Autophagy Network Restrains Intestinal Stem Cell Proliferation by Counteracting EGFR-ERK Signaling. PMID:31006650
Isocitrate dehydrogenase1 mutation reduces the pericyte coverage of microvessels in astrocytic tumours. PMID:31004262
JAK2/PD-L1/PD-L2 (9p24.1) amplifications in renal cell carcinomas with sarcomatoid transformation: implications for clinical management. PMID:30996253
A Novel Mechanism Driving Poor-Prognosis Prostate Cancer: Overexpression of the DNA Repair Gene, Ribonucleotide Reductase Small Subunit M2 (RRM2). PMID:30996073
Analysis of cyclin E co-expression genes reveals nuclear transcription factor Y subunit alpha is an oncogene in gastric cancer. PMID:30993263
Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients. PMID:30992440
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment. PMID:30992437
A Human Organotypic Microfluidic Tumor Model Permits Investigation of the Interplay between Patient-Derived Fibroblasts and Breast Cancer Cells. PMID:30992322
Systematic Multiomics Analysis of Alterations in C1QBP mRNA Expression and Relevance for Clinical Outcomes in Cancers. PMID:30991713
Expression of GLUT1 in Pseudopalisaded and Perivascular Tumor Cells Is an Independent Prognostic Factor for Patients With Glioblastomas. PMID:30990881
Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells. PMID:30987626
CDK11 Loss Induces Cell Cycle Dysfunction and Death of BRAF and NRAS Melanoma Cells. PMID:30987032
Remodeling the cancer epigenome: mutations in the SWI/SNF complex offer new therapeutic opportunities. PMID:30986130
Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas. PMID:30979734
Reduced FRG1 expression promotes prostate cancer progression and affects prostate cancer cell migration and invasion. PMID:30975102
Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses. PMID:30975030
Solid pseudopapillary neoplasms of the pancreas are dependent on the Wnt pathway. PMID:30972907
Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner. PMID:30971297
MED28 Over-Expression Shortens the Cell Cycle and Induces Genomic Instability. PMID:30970566
Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment. PMID:30970447
Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness. PMID:30967630
PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells. PMID:30967629
DNA Repair Gene Expression Adjusted by the PCNA Metagene Predicts Survival in Multiple Cancers. PMID:30965671
Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients. PMID:30963401
Benefit from anti-EGFRs in RAS and BRAF wild-type metastatic transverse colon cancer: a clinical and molecular proof of concept study. PMID:30962964
An age-based, RNA expression paradigm for survival biomarker identification for pediatric neuroblastoma and acute lymphoblastic leukemia. PMID:30962767
Tools To Live By: Bacterial DNA Structures Illuminate Cancer. PMID:30962000
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma. PMID:30957641
Transcriptomics-based validation of the relatedness of heterogeneous nuclear ribonucleoproteins to chronic lymphocytic leukemia as potential biomarkers of the disease aggressiveness. PMID:30957125
A global immune gene expression signature for human cancers. PMID:30956779
Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer. PMID:30956167
Interleukin 32 expression in human melanoma. PMID:30953519
An unbiased in vitro screen for activating epidermal growth factor receptor mutations. PMID:30952700
Risk of cognition alteration and emotional frailty via circulating transcriptome in treatment naïve head and neck squamous cell cancer patients. PMID:30949427
Elucidating the transcriptional program of feline injection-site sarcoma using a cross-species mRNA-sequencing approach. PMID:30947707
G Protein γ subunit 7 loss contributes to progression of clear cell renal cell carcinoma. PMID:30945310
Upregulated forkhead-box A3 elevates the expression of forkhead-box A1 and forkhead-box A2 to promote metastasis in esophageal cancer. PMID:30944629
Gene profiling of HepG2 cells following nitidine chloride treatment: An investigation with microarray and Connectivity Mapping. PMID:30942464
Tumor mutation burden and recurrent tumors in hereditary lung cancer. PMID:30941903
Phase II Study of Lenvatinib in Patients With Progressive, Recurrent or Metastatic Adenoid Cystic Carcinoma. PMID:30939095
The Role of ZNF143 in Breast Cancer Cell Survival Through the NAD(P)H Quinone Dehydrogenase 1⁻p53⁻Beclin1 Axis Under Metabolic Stress. PMID:30935019
Expression patterns and the prognostic value of the SMYD family members in human breast carcinoma using integrative bioinformatics analysis. PMID:30930987
MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation. PMID:30928206
Genomic subtyping and therapeutic targeting of acute erythroleukemia. PMID:30926971
Clinically Integrated Molecular Diagnostics in Adenoid Cystic Carcinoma. PMID:30926674
PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise? PMID:30925702
Genomic signature of parity in the breast of premenopausal women. PMID:30922380
MicroRNA-4417 is a tumor suppressor and prognostic biomarker for triple-negative breast cancer. PMID:30922194
Identification of gene-phenotype connectivity associated with flavanone naringenin by functional network analysis. PMID:30918758
Identification and characterization of two novel oncogenic mTOR mutations. PMID:30918329
Functional Diversity of p53 in Human and Wild Animals. PMID:30915036
Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells. PMID:30914776
The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy. PMID:30914656
Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer. PMID:30914635
Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients. PMID:30914425
Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. PMID:30911680
FAM83D is associated with gender, AJCC stage, overall survival and disease-free survival in hepatocellular carcinoma. PMID:30910840
MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma. PMID:30910803
The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas. PMID:30908539
Systematic Survey of the Role of IGF in the Link Between Diabetes and Cancer. PMID:30906876
Role of pre-miR-532 (miR-532-5p and miR-532-3p) in regulation of gene expression and molecular pathogenesis in renal cell carcinoma. PMID:30906802
Network Pharmacology Analysis of Damnacanthus indicus C.F.Gaertn in Gene-Phenotype. PMID:30906409
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer. PMID:30905761
FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. PMID:30903103
Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications. PMID:30902996
Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC. PMID:30902071
Origin of mutations in genes associated with human glioblastoma multiform cancer: random polymerase errors versus deamination. PMID:30899826
Depletion of H3K79 methyltransferase Dot1L promotes cell invasion and cancer stem-like cell property in ovarian cancer. PMID:30899413
STOML2 as a novel prognostic biomarker modulates cell proliferation, motility and chemo-sensitivity via IL6-Stat3 pathway in head and neck squamous cell carcinoma. PMID:30899371
Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells. PMID:30898113
Lack of galectin-1 exacerbates chronic hepatitis, liver fibrosis, and carcinogenesis in murine hepatocellular carcinoma model. PMID:30897344
Differentially expressed gene profile and relevant pathways of the traditional Chinese medicine cinobufotalin on MCF‑7 breast cancer cells. PMID:30896874
Diagnostic and prognostic value of CEP55 in clear cell renal cell carcinoma as determined by bioinformatics analysis. PMID:30896867
Genome-scale integrated analysis to identify prospective molecular mechanisms and therapeutic targets in isocitrate dehydrogenase 2 R140Q-mutated acute myeloid leukemia. PMID:30896832
The expression, significance and function of cancer susceptibility candidate 9 in lung squamous cell carcinoma: A bioinformatics and in vitro investigation. PMID:30896821
Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2-Robo1 signalling on cell migration and EMT. PMID:30896071
A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma. PMID:30894629
DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination. PMID:30893604
S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2. PMID:30885944
NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer. PMID:30885209
Villi development core-related gene expression associated with lung squamous cancer prognosis. PMID:30882635
MiR-1-3p Inhibits Lung Adenocarcinoma Cell Tumorigenesis via Targeting Protein Regulator of Cytokinesis 1. PMID:30881920
The Highly Expressed FAM83F Protein in Papillary Thyroid Cancer Exerts a Pro-Oncogenic Role in Thyroid Follicular Cells. PMID:30881348
Long noncoding RNA H19 is a critical oncogenic driver and contributes to epithelial-mesenchymal transition in papillary thyroid carcinoma. PMID:30881130
An immunosuppressive macrophage profile attenuates the prognostic impact of CD20-positive B cells in human soft tissue sarcoma. PMID:30879106
Gene signatures and prognostic values of m6A regulators in clear cell renal cell carcinoma - a retrospective study using TCGA database. PMID:30877265
Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis. PMID:30877170
Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer. PMID:30875794
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy. PMID:30873179
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma. PMID:30872592
Examination of Independent Prognostic Power of Gene Expressions and Histopathological Imaging Features in Cancer. PMID:30871256
Multiomics Analysis Reveals that GLS and GLS2 Differentially Modulate the Clinical Outcomes of Cancer. PMID:30871151
Mutations in gliclazide-associated genes may predict poor bladder cancer prognosis. PMID:30868054
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme. PMID:30867843
Resistance to lysosomotropic drugs used to treat kidney and breast cancers involves autophagy and inflammation and converges in inducing CXCL5. PMID:30867824
ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism. PMID:30867319
Bioinformatic exploration of OLFML2B overexpression in gastric cancer base on multiple analyzing tools. PMID:30866865
GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells toward Breast Tumor Progression. PMID:30866584
FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer. PMID:30865895
Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cells. PMID:30863489
Promising diagnostic and prognostic value of E2Fs in human hepatocellular carcinoma. PMID:30863181
Polo-like kinase 3 is associated with poor prognosis and regulates proliferation and metastasis in prostate cancer. PMID:30863161
Significant prognostic values of aquaporin mRNA expression in breast cancer. PMID:30863160
AP001056.1, A Prognosis-Related Enhancer RNA in Squamous Cell Carcinoma of the Head and Neck. PMID:30862109
Assessment of intra-tumoural colorectal cancer prognostic biomarkers using RNA in situ hybridisation. PMID:30858927
Gene regulation by antitumor miR-130b-5p in pancreatic ductal adenocarcinoma: the clinical significance of oncogenic EPS8. PMID:30858505
Computational analysis of the evolutionarily conserved Missing In Metastasis/Metastasis Suppressor 1 gene predicts novel interactions, regulatory regions and transcriptional control. PMID:30858428
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma. PMID:30858363
Enrichment of short mutant cell-free DNA fragments enhanced detection of pancreatic cancer. PMID:30857943
Prognostic and Clinicopathological Significance of SERTAD1 in Various Types of Cancer Risk: A Systematic Review and Retrospective Analysis. PMID:30857225
Analysis of cell-free circulating tumor DNA in 419 patients with glioblastoma and other primary brain tumors. PMID:30855176
Overexpression of FZD1 is Associated with a Good Prognosis and Resistance of Sunitinib in Clear Cell Renal Cell Carcinoma. PMID:30854133
Mechanisms of MTH1 inhibition-induced DNA strand breaks: The slippery slope from the oxidized nucleotide pool to genotoxic damage. PMID:30852368
Identification of Potential Candidate Genes of Oral Cancer in Response to Chronic Infection With Porphyromonas gingivalis Using Bioinformatical Analyses. PMID:30847302
Quantifying Tip60 (Kat5) stratifies breast cancer. PMID:30846725
Functional genomics screen with pooled shRNA library and gene expression profiling with extracts of Azadirachta indica identify potential pathways for therapeutic targets in head and neck squamous cell carcinoma. PMID:30842898
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. PMID:30842661
Diverse tumour susceptibility in Collaborative Cross mice: identification of a new mouse model for human gastric tumourigenesis. PMID:30842212
Genomic landscape of inverted urothelial papilloma and urothelial papilloma of the bladder. PMID:30838648
Alternative Splicing of MXD3 and Its Regulation of MXD3 Levels in Glioblastoma. PMID:30838212
DNA Ligase IV Prevents Replication Fork Stalling and Promotes Cellular Proliferation in Triple Negative Breast Cancer. PMID:30838131
Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors. PMID:30835255
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers. PMID:30833748
GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation. PMID:30830860
Tumor mutational profile of triple negative breast cancer patients in Thailand revealed distinctive genetic alteration in chromatin remodeling gene. PMID:30828495
ESR1 mutations in metastatic lobular breast cancer patients. PMID:30820448
Synergy from gene expression and network mining (SynGeNet) method predicts synergistic drug combinations for diverse melanoma genomic subtypes. PMID:30820351
POLE proofreading defects: Contributions to mutagenesis and cancer. PMID:30818169
Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer. PMID:30816541
Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of patients with head and neck cancer. PMID:30816478
Comprehensive sequencing of the myocilin gene in a selected cohort of severe primary open-angle glaucoma patients. PMID:30816137
IPCT: Integrated Pharmacogenomic Platform of Human Cancer Cell Lines and Tissues. PMID:30813377
Exome sequencing in 51 early onset non-familial CRC cases. PMID:30809968
Tumor suppressor MCPH1 regulates gene expression profiles related to malignant conversion and chromosomal assembly. PMID:30809794
VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness. PMID:30809300
β-catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancer. PMID:30809277
Combined expression and prognostic significance of PPFIA1 and ALG3 in head and neck squamous cell carcinoma. PMID:30805892
UBTD1 is a mechano-regulator controlling cancer aggressiveness. PMID:30804013
Novel genetic alterations and their impact on target therapy response in head and neck squamous cell carcinoma. PMID:30799957
The prognostic landscape of interactive biological processes presents treatment responses in cancer. PMID:30799199
Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer. PMID:30795624
The promising novel biomarkers and candidate small molecule drugs in kidney renal clear cell carcinoma: Evidence from bioinformatics analysis of high-throughput data. PMID:30793530
FBXW7 in Cancer: What Has Been Unraveled Thus Far? PMID:30791487
Dysregulation, functional implications, and prognostic ability of the circadian clock across cancers. PMID:30791227
Comprehensive clinical implications of homeobox A10 in 3,199 cases of non-small cell lung cancer tissue samples combining qRT-PCR, RNA sequencing and microarray data. PMID:30787969
Attenuated ZHX3 expression serves as a potential biomarker that predicts poor clinical outcomes in breast cancer patients. PMID:30787639
Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities. PMID:30782821
Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. PMID:30782064
Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer. PMID:30777101
Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells. PMID:30775443
LncRNA PCAT1 activates AKT and NF-κB signaling in castration-resistant prostate cancer by regulating the PHLPP/FKBP51/IKKα complex. PMID:30773595
A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. PMID:30773340
Overexpression of BUB1B, CCNA2, CDC20, and CDK1 in tumor tissues predicts poor survival in pancreatic ductal adenocarcinoma. PMID:30765611
Ectopic Otoconin 90 expression in triple negative breast cancer cell lines is associated with metastasis functions. PMID:30763339
Complex harmonic regularization with differential evolution in a memetic framework for biomarker selection. PMID:30763332
Molecular diagnosis of somatic overgrowth conditions: A single-center experience. PMID:30761771
Impact of the SPOP Mutant Subtype on the Interpretation of Clinical Parameters in Prostate Cancer. PMID:30761387
Genome-wide expression analysis reveals six contravened targets of EZH2 associated with breast cancer patient survival. PMID:30760814
NRF2 Activation in Cancer: From DNA to Protein. PMID:30760522
Semaphorin 3C as a Therapeutic Target in Prostate and Other Cancers. PMID:30759745
Ventricular-Subventricular Zone Contact by Glioblastoma is Not Associated with Molecular Signatures in Bulk Tumor Data. PMID:30755636
Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer. PMID:30755611
YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis. PMID:30755404
Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression. PMID:30755372
Low let-7d and high miR-205 expression levels positively influence HNSCC patient outcome. PMID:30755200
ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses. PMID:30754719
Variation in the repulsive guidance molecule family in human populations. PMID:30746893
Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1. PMID:30744692
Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E. PMID:30744688
SAMD5 mRNA was overexpressed in prostate cancer and can predict biochemical recurrence after radical prostatectomy. PMID:30739268
A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection. PMID:30737406
The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis. PMID:30737284
Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies. PMID:30737244
Pyruvate Kinase M2 serves as blockade for nucleosome repositioning and abrogates Chd7 remodeling activity. PMID:30735509
POLE-mutated clear cell cervical cancer associated with in-utero diethylstilbestrol exposure. PMID:30733993
Personalization of Logical Models With Multi-Omics Data Allows Clinical Stratification of Patients. PMID:30733688
Does functional specialization of ribosomes really exist? PMID:30733326
Functional characterization of a novel CSF1R mutation causing hereditary diffuse leukoencephalopathy with spheroids. PMID:30729751
pAKT pathway activation is associated with PIK3CA mutations and good prognosis in luminal breast cancer in contrast to p-mTOR pathway activation. PMID:30729154
Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells. PMID:30729097
Data mining for mutation-specific targets in acute myeloid leukemia. PMID:30728456
Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer. PMID:30728399
IFN regulatory factor-8 expression in macrophages governs an antimetastatic program. PMID:30728331
Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer. PMID:30728081
Identification of different gene expressions between diffuse- and intestinal-type spheroid-forming gastric cancer cells. PMID:30726523
The Expression Patterns of FAM83H and PANX2 Are Associated With Shorter Survival of Clear Cell Renal Cell Carcinoma Patients. PMID:30723706
A Guide to PIN1 Function and Mutations Across Cancers. PMID:30723410
The Proliferative and Apoptotic Landscape of Basal-like Breast Cancer. PMID:30720718
Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer. PMID:30719498
High FOXM1 expression is a prognostic marker for poor clinical outcomes in prostate cancer. PMID:30719174
The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic. PMID:30718927
TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells. PMID:30718921
Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets. PMID:30718226
CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT/GSK-3β/β-catenin pathway. PMID:30717785
Exploiting DNA repair defects in colorectal cancer. PMID:30714316
Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer. PMID:30709841
Peripheral Circulating Tumor DNA Detection Predicts Poor Outcomes After Liver Resection for Metastatic Colorectal Cancer. PMID:30706231
High-throughput RNAi screening reveals cancer-selective lethal targets in the RNA spliceosome. PMID:30705407
Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis. PMID:30705405
Identification of key genes and pathways in hepatocellular carcinoma: A preliminary bioinformatics analysis. PMID:30702595
Prognostic values of GMPS, PR, CD40, and p21 in ovarian cancer. PMID:30701134
Heterozygous mutations cause genetic instability in a yeast model of cancer evolution. PMID:30700905
VICKZ1 enhances tumor progression and metastasis in lung adenocarcinomas in mice. PMID:30700831
Differentiating between cancer and normal tissue samples using multi-hit combinations of genetic mutations. PMID:30700767
Mutation Hotspots in the β-Catenin Gene: Lessons from the Human Cancer Genome Databases. PMID:30699286
Deficiency of mismatch repair genes is less frequently observed in signet ring cell compared with non-signet ring cell gastric cancer. PMID:30694393
The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis. PMID:30692632
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. PMID:30692626
Data Lakes, Clouds, and Commons: A Review of Platforms for Analyzing and Sharing Genomic Data. PMID:30691868
Outcome and molecular characteristics of non-invasive encapsulated follicular variant of papillary thyroid carcinoma with oncocytic features. PMID:30689169
PKR: A Kinase to Remember. PMID:30686999
PRDM16 functions as a suppressor of lung adenocarcinoma metastasis. PMID:30683132
Carbonic Anhydrase 6 Gene Variation influences Oral Microbiota Composition and Caries Risk in Swedish adolescents. PMID:30679524
Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment. PMID:30679171
3D Mammary Epithelial Cell Models: A Goldmine of DCIS Biomarkers and Morphogenetic Mechanisms. PMID:30678048
Utility of the JAX Clinical Knowledgebase in capture and assessment of complex genomic cancer data. PMID:30675517
Use case driven evaluation of open databases for pediatric cancer research. PMID:30675185
Thymine DNA glycosylase as a novel target for melanoma. PMID:30674989
Testicular germ cell tumor: a comprehensive review. PMID:30671589
Expression and gene regulation network of RBM8A in hepatocellular carcinoma based on data mining. PMID:30670676
Alternating Electric Fields (TTFields) Activate Cav1.2 Channels in Human Glioblastoma Cells. PMID:30669316
BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer. PMID:30667054
Development of a prognostic index based on an immunogenomic landscape analysis of papillary thyroid cancer. PMID:30661062
The RANK-RANKL axis: an opportunity for drug repurposing in cancer? PMID:30656607
Deletion of C9orf53 promotes the growth of head and neck squamous cell carcinoma and is associated with poor prognosis of patients with head and neck squamous cell carcinoma. PMID:30655888
Significance of TERT and ATRX mutations in glioma. PMID:30655743
Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells. PMID:30654593
Molecular features of premenopausal breast cancers in Latin American women: Pilot results from the PRECAMA study. PMID:30653559
Synoptic Reporting: Evidence-Based Review and Future Directions. PMID:30652566
American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond-Lessons Learned and Member Institutions' Perspectives. PMID:30652542
Wild-type p53 regulates OTOP2 transcription through DNA loop alteration of the promoter in colorectal cancer. PMID:30652071
Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning. PMID:30652029
Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases. PMID:30651352
Impact of p85α Alterations in Cancer. PMID:30650664
Overcoming Intrinsic and Acquired Cetuximab Resistance in RAS Wild-Type Colorectal Cancer: An In Vitro Study on the Expression of HER Receptors and the Potential of Afatinib. PMID:30650638
p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value. PMID:30650356
Biological Interpretation of Complex Genomic Data. PMID:30649721
Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer. PMID:30647855
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma. PMID:30647454
Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice. PMID:30644386
Robust analysis of novel mRNA-lncRNA cross talk based on ceRNA hypothesis uncovers carcinogenic mechanism and promotes diagnostic accuracy in esophageal cancer. PMID:30643460
ATDC mediates a TP63-regulated basal cancer invasive program. PMID:30643195
RCBTB1 Deletion Is Associated with Metastatic Outcome and Contributes to Docetaxel Resistance in Nontranslocation-Related Pleomorphic Sarcomas. PMID:30641971
Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage. PMID:30633903
Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy. PMID:30628708
Characterization of Tumor-Suppressor Gene Inactivation Events in 33 Cancer Types. PMID:30625331
Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma. PMID:30622339
The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis. PMID:30622257
The transcriptome landscape of the carcinogenic treatment response in the blind mole rat: insights into cancer resistance mechanisms. PMID:30621584
Over-Expression of βII-Tubulin and Especially Its Localization in Cell Nuclei Correlates with Poorer Outcomes in Colorectal Cancer. PMID:30621030
Unbiased data mining identifies cell cycle transcripts that predict non-indolent Gleason score 7 prostate cancer. PMID:30616540
DNMT3A/3B overexpression might be correlated with poor patient survival, hypermethylation and low expression of ESR1/PGR in endometrioid carcinoma: an analysis of The Cancer Genome Atlas. PMID:30614867
Notch signaling activation induces cell death in MAPKi-resistant melanoma cells. PMID:30614626
Target sequencing of cancer-related genes in early esophageal squamous neoplasia resected by endoscopic resection in Japanese patients. PMID:30613367
Transcriptomic analyses identify key differentially expressed genes and clinical outcomes between triple-negative and non-triple-negative breast cancer. PMID:30613165
Next Generation-Targeted Amplicon Sequencing (NG-TAS): an optimised protocol and computational pipeline for cost-effective profiling of circulating tumour DNA. PMID:30609936
IGFBP7 Drives Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition in Lung Cancer. PMID:30609749
CEP55 promotes epithelial-mesenchymal transition in renal cell carcinoma through PI3K/AKT/mTOR pathway. PMID:30607788
SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program. PMID:30606720
Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. PMID:30604775
Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set. PMID:30602777
Chromatin regulatory mechanisms and therapeutic opportunities in cancer. PMID:30602726
Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem Cell and Proliferative Breast Cancer Cell Fates. PMID:30597041
Targeted Profiling of Heat Shock Proteome in Radioresistant Breast Cancer Cells. PMID:30596229
Prognostic and clinicopathological value of FoxM1 expression in colorectal cancer: A systematic review and meta-analysis. PMID:30593202
Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer. PMID:30590044
A comprehensive review of available omics data resources and molecular profiling for precision glioma studies. PMID:30588296
Systematic Analysis of Gene Expression Alteration and Co-Expression Network of Eukaryotic Initiation Factor 4A-3 in Cancer. PMID:30588240
An Analysis of the Expression and Association with Immune Cell Infiltration of the cGAS/STING Pathway in Pan-Cancer. PMID:30583098
Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer. PMID:30583079
Phosphatidylinositol 3-kinase pathway genomic alterations in 60,991 diverse solid tumors informs targeted therapy opportunities. PMID:30582752
A novel role for DGATs in cancer. PMID:30579761
Gene expression analysis of heat-shock proteins and redox regulators reveals combinatorial prognostic markers in carcinomas of the gastrointestinal tract. PMID:30578123
Inter- and intra-tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas. PMID:30575147
Drug-target-disease network analysis of gene-phenotype connectivity for genistein in ovarian cancer. PMID:30573976
Impact of RAS mutation subtype on clinical outcome-a cross-entity comparison of patients with advanced non-small cell lung cancer and colorectal cancer. PMID:30568222
Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer. PMID:30563893
The Prognostic Value of Cell Cycle Gene Expression Signatures in Muscle Invasive, High-Grade Bladder Cancer. PMID:30561442
Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells. PMID:30559934
Expression of FGD4 positively correlates with the aggressive phenotype of prostate cancer. PMID:30558664
Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma. PMID:30558661
Rac GTPases in Hematological Malignancies. PMID:30558116
The Oncogenic Functions of MASTL Kinase. PMID:30555827
Germline BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance associated with breast/ovarian cancer: a report from North India. PMID:30555256
Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 signalling in head and neck squamous cell carcinoma. PMID:30555157
Mutational profiles of persistent/recurrent laryngeal squamous cell carcinoma. PMID:30548484
SIU-ICUD consultation on bladder cancer: basic science. PMID:30547196
Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health. PMID:30545954
Upregulation of Long Non-Coding RNA DRAIC Correlates with Adverse Features of Breast Cancer. PMID:30544991
Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer. PMID:30544563
SMYD3 promotes the epithelial-mesenchymal transition in breast cancer. PMID:30544196
TP53 mutations as potential prognostic markers for specific cancers: analysis of data from The Cancer Genome Atlas and the International Agency for Research on Cancer TP53 Database. PMID:30542790
Long non-coding RNA LOC285194 functions as a tumor suppressor by targeting p53 in non-small cell lung cancer. PMID:30542733
PI3Kβ inhibitor AZD6482 exerts antiproliferative activity and induces apoptosis in human glioblastoma cells. PMID:30542720
Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bio-orthogonally Conjugated Drug. PMID:30540482
Integrated analysis reveals key genes with prognostic value in lung adenocarcinoma. PMID:30538558
TET2-Dependent Hydroxymethylome Plasticity Reduces Melanoma Initiation and Progression. PMID:30538121
Identification and Characterization of Synthetic Viability with ERCC1 Deficiency in Response to Interstrand Crosslinks in Lung Cancer. PMID:30538112
Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment. PMID:30538091
PDX Finder: A portal for patient-derived tumor xenograft model discovery. PMID:30535239
LCE: an open web portal to explore gene expression and clinical associations in lung cancer. PMID:30532070
Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition. PMID:30532030
CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development. PMID:30531840
Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling. PMID:30530503
Systematic identification of mutations and copy number alterations associated with cancer patient prognosis. PMID:30526857
Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models. PMID:30526553
Adipocytes and Obesity-Related Conditions Jointly Promote Breast Cancer Cell Growth and Motility: Associations With CAP1 for Prognosis. PMID:30524378
OMCD: OncomiR Cancer Database. PMID:30522456
Comprehensive Analysis of BAP1 Somatic Mutation in Clear Cell Renal Cell Carcinoma to Explore Potential Mechanisms in Silico. PMID:30519310
m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression. PMID:30518868
A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. PMID:30518210
Cullin-3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2-positive breast cancer cells. PMID:30515933
Loss of function, missense, and intronic variants in NOTCH1 confer different risks for left ventricular outflow tract obstructive heart defects in two European cohorts. PMID:30511478
Cyclin E1 and Rb modulation as common events at time of resistance to palbociclib in hormone receptor-positive breast cancer. PMID:30511015
Deletion of 3p13 is a late event linked to progression of TMPRSS2:ERG fusion prostate cancer. PMID:30510458
MSIpred: a python package for tumor microsatellite instability classification from tumor mutation annotation data using a support vector machine. PMID:30510242
Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers. PMID:30508726
Financially effective test algorithm to identify an aggressive, EGFR-amplified variant of IDH-wildtype, lower-grade diffuse glioma. PMID:30496526
CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. PMID:30487607
Overexpression of MUC1 predicts poor prognosis in patients with breast cancer. PMID:30483806
Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations. PMID:30482722
Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients. PMID:30481161
The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. PMID:30480076
Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells. PMID:30475204
Targets and genomic constraints of ectopic Dnmt3b expression. PMID:30468428
Different behaviour of DVL1, DVL2, DVL3 in astrocytoma malignancy grades and their association to TCF1 and LEF1 upregulation. PMID:30468298
EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer. PMID:30463996
Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells. PMID:30463939
Effects of PKM2 on global metabolic changes and prognosis in hepatocellular carcinoma: from gene expression to drug discovery. PMID:30463528
Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism. PMID:30463017
Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis. PMID:30460631
The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis. PMID:30460237
A comparative analysis of KMT2D missense variants in Kabuki syndrome, cancers and the general population. PMID:30459467
Estrogen receptor β promotes bladder cancer growth and invasion via alteration of miR-92a/DAB2IP signals. PMID:30459405
Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment. PMID:30458886
Machine Learning With K-Means Dimensional Reduction for Predicting Survival Outcomes in Patients With Breast Cancer. PMID:30455569
Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. PMID:30454645
Targeted sequencing of plasmacytoid urothelial carcinoma reveals frequent TERT promoter mutations. PMID:30447301
HHLA2 is a novel immune checkpoint protein in pancreatic ductal adenocarcinoma and predicts post-surgical survival. PMID:30447255
RET rearrangements are actionable alterations in breast cancer. PMID:30446652
Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma. PMID:30445726
15 years of PhosphoSitePlus®: integrating post-translationally modified sites, disease variants and isoforms. PMID:30445427
Pirin: a potential novel therapeutic target for castration-resistant prostate cancer regulated by miR-455-5p. PMID:30444038
The transcriptional coactivator WBP2 primes triple-negative breast cancer cells for responses to Wnt signaling via the JNK/Jun kinase pathway. PMID:30442712
Advances in HER2-Targeted Therapy: Novel Agents and Opportunities Beyond Breast and Gastric Cancer. PMID:30442682
Immunogenomic Landscape Contributes to Hyperprogressive Disease after Anti-PD-1 Immunotherapy for Cancer. PMID:30439581
Restoration of FBP1 suppressed Snail-induced epithelial to mesenchymal transition in hepatocellular carcinoma. PMID:30429463
Downregulation of IQGAP2 Correlates with Prostate Cancer Recurrence and Metastasis. PMID:30428404
Regional differences in gallbladder cancer pathogenesis: Insights from a multi-institutional comparison of tumor mutations. PMID:30427539
MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers. PMID:30425131
Cell Origins of High-Grade Serous Ovarian Cancer. PMID:30424539
The interaction of p130Cas with PKN3 promotes malignant growth. PMID:30422386
Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13. PMID:30422115
SETD2 mutations in primary central nervous system tumors. PMID:30419952
Association of specific gene mutations derived from machine learning with survival in lung adenocarcinoma. PMID:30419062
A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer. PMID:30414698
A cancer tissue-specific FAM72 expression profile defines a novel glioblastoma multiform (GBM) gene-mutation signature. PMID:30414097
The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance. PMID:30413706
Over expression of DNA damage and cell cycle dependent proteins are associated with poor survival in patients with adrenocortical carcinoma. PMID:30413320
Development of a Novel Autophagy-related Prognostic Signature for Serous Ovarian Cancer. PMID:30410611
CDK5 Functions as a Tumor Promoter in Human Lung Cancer. PMID:30410599
Cancer3D 2.0: interactive analysis of 3D patterns of cancer mutations in cancer subsets. PMID:30407596
Genomic Network-Based Analysis Reveals Pancreatic Adenocarcinoma Up-Regulating Factor-Related Prognostic Markers in Cervical Carcinoma. PMID:30406031
CDK9 Expression Shows Role as a Potential Prognostic Biomarker in Breast Cancer Patients Who Fail to Achieve Pathologic Complete Response after Neoadjuvant Chemotherapy. PMID:30405916
The anti-psychotic drug pimozide is a novel chemotherapeutic for breast cancer. PMID:30405882
Emerging Roles of Fibroblast Growth Factor 10 in Cancer. PMID:30405704
Polyamine synthesis as a target of MYC oncogenes. PMID:30404920
Criticality in tumor evolution and clinical outcome. PMID:30404913
Managing Clonal Hematopoiesis in Patients With Solid Tumors. PMID:30403571
Unbalanced YAP-SOX9 circuit drives stemness and malignant progression in esophageal squamous cell carcinoma. PMID:30401982
Cell Surface Notch Ligand DLL3 is a Therapeutic Target in Isocitrate Dehydrogenase-mutant Glioma. PMID:30397180
Metastasis Suppressor NME1 Directly Activates Transcription of the ALDOC Gene in Melanoma Cells. PMID:30396920
Tumor stroma-infiltrating mast cells predict prognosis and adjuvant chemotherapeutic benefits in patients with muscle invasive bladder cancer. PMID:30393586
Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer. PMID:30393068
Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases. PMID:30393067
Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma. PMID:30389701
KDM5A Regulates a Translational Program that Controls p53 Protein Expression. PMID:30388705
Tumor mutational burden is a determinant of immune-mediated survival in breast cancer. PMID:30386679
Recovery of T-cell receptor V(D)J recombination reads from lower grade glioma exome files correlates with reduced survival and advanced cancer grade. PMID:30382482
VISTA expressed in tumour cells regulates T cell function. PMID:30382166
Genomic and Transcriptomic Characterization Links Cell Lines with Aggressive Head and Neck Cancers. PMID:30380422
Involvement of dual-strand of the miR-144 duplex and their targets in the pathogenesis of lung squamous cell carcinoma. PMID:30375717
Loss of GAS5 tumour suppressor lncRNA: an independent molecular cancer biomarker for short-term relapse and progression in bladder cancer patients. PMID:30374124
Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival. PMID:30373918
Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients to Targeted and Immune Therapies. PMID:30373752
SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics. PMID:30373609
Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth. PMID:30367629
Single-cell RNA-seq analysis reveals the platinum resistance gene COX7B and the surrogate marker CD63. PMID:30367559
Bclaf1 promotes angiogenesis by regulating HIF-1α transcription in hepatocellular carcinoma. PMID:30367150
Examination of the expression and prognostic significance of DLGAPs in gastric cancer using the TCGA database and bioinformatic analysis. PMID:30365066
Upregulation of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in Tumor Tissues Predicted Worse Overall Survival and Disease-Free Survival in Hepatocellular Carcinoma Patients. PMID:30363964
FBXO17 promotes cell proliferation through activation of Akt in lung adenocarcinoma cells. PMID:30359271
Molecular classification and subtype-specific drug sensitivity research of uterine carcinosarcoma under multi-omics framework. PMID:30359167
PTPN11 Plays Oncogenic Roles and Is a Therapeutic Target for BRAF Wild-Type Melanomas. PMID:30355677
Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast Cancer. PMID:30355675
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer. PMID:30353166
DNA Methylation Predicts the Response of Triple-Negative Breast Cancers to All-Trans Retinoic Acid. PMID:30352973
DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway. PMID:30352910
Somatic mutations in renal cell carcinomas from Chinese patients revealed by whole exome sequencing. PMID:30349421
Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer. PMID:30349298
Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer. PMID:30348992
Ribosome biogenesis factor Ltv1 chaperones the assembly of the small subunit head. PMID:30348748
CD11c-Positive Dendritic Cells in Triple-negative Breast Cancer. PMID:30348717
Inverse Relationship Between Polio Incidence in the US and Colorectal Cancer. PMID:30348706
Identification of SUV39H2 as a potential oncogene in lung adenocarcinoma. PMID:30348215
Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress. PMID:30347795
Therapeutic potential of targeting the Eph/ephrin signaling complex. PMID:30343150
H19 regulation of oestrogen induction of symmetric division is achieved by antagonizing Let-7c in breast cancer stem-like cells. PMID:30338598
Concomitant targeting of the mTOR/MAPK pathways: novel therapeutic strategy in subsets of RICTOR/KRAS-altered non-small cell lung cancer. PMID:30338041
New insights into long noncoding RNAs and pseudogenes in prognosis of renal cell carcinoma. PMID:30337839
Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene. PMID:30333512
Genetic and Epigenetic Determinants of Aggressiveness in Cribriform Carcinoma of the Prostate. PMID:30333152
Integrative cancer patient stratification via subspace merging. PMID:30329022
RalB directly triggers invasion downstream Ras by mobilizing the Wave complex. PMID:30320548
Prognostic value of DKK2 from the Dickkopf family in human breast cancer. PMID:30320375
Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN-FOS at composite DNA sites. PMID:30315111
Integrative analysis of transcriptomics and clinical data uncovers the tumor-suppressive activity of MITF in prostate cancer. PMID:30310055
Clinical Impact of Tumor Mutational Burden in Neuroblastoma. PMID:30307503
Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas. PMID:30306125
Comparison of breast cancer metastasis models reveals a possible mechanism of tumor aggressiveness. PMID:30305609
Genomic analysis of DNA repair genes and androgen signaling in prostate cancer. PMID:30305041
Detection of endometrial precancer by a targeted gynecologic cancer liquid biopsy. PMID:30301868
Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells. PMID:30297743
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells. PMID:30293938
Heterozygous loss-of-function variants of MEIS2 cause a triad of palatal defects, congenital heart defects, and intellectual disability. PMID:30291340
ADAR1-mediated RNA-editing of 3'UTRs in breast cancer. PMID:30290838
Identification of Key Genes and Pathways Associated with RUNX1 Mutations in Acute Myeloid Leukemia Using Bioinformatics Analysis. PMID:30289875
Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy. PMID:30289335
Systematic expression alteration analysis of master reprogramming factor OCT4 and its three pseudogenes in human cancer and their prognostic outcomes. PMID:30287838
Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment. PMID:30285883
Durable response to anti-PD-1 immunotherapy in epithelioid angiomyolipoma: a report on the successful treatment of a rare malignancy. PMID:30285856
Quantitative phosphoproteomic analysis identifies novel functional pathways of tumor suppressor DLC1 in estrogen receptor positive breast cancer. PMID:30278072
Application of weighted gene co-expression network analysis to identify key modules and hub genes in oral squamous cell carcinoma tumorigenesis. PMID:30275705
High Expression of EpCAM and Sox2 is a Positive Prognosticator of Clinical Outcome for Head and Neck Carcinoma. PMID:30275505
Molecular Lesions of Insulator CTCF and Its Paralogue CTCFL (BORIS) in Cancer: An Analysis from Published Genomic Studies. PMID:30275357
TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis. PMID:30274972
Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5. PMID:30271790
Expressions and prognostic values of the E2F transcription factors in human breast carcinoma. PMID:30271201
ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer. PMID:30270106
Host IDO2 Gene Status Influences Tumor Progression and Radiotherapy Response in KRAS-Driven Sporadic Pancreatic Cancers. PMID:30266763
Mechanism and prognostic value of indoleamine 2,3-dioxygenase 1 expressed in hepatocellular carcinoma. PMID:30264546
Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase. PMID:30261690
A prognostic mRNA expression signature of four 16q24.3 genes in radio(chemo)therapy-treated head and neck squamous cell carcinoma (HNSCC). PMID:30259648
CD38 is methylated in prostate cancer and regulates extracellular NAD. PMID:30258629
Key elements involved in Epstein-Barr virus-associated gastric cancer and their network regulation. PMID:30258285
A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes. PMID:30258054
Association of Pioglitazone with Increased Risk of Prostate Cancer and Pancreatic Cancer: A Functional Network Study. PMID:30255424
Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity. PMID:30254278
Differential expressions of integrin-linked kinase, β-parvin and cofilin 1 in high-fat diet induced prostate cancer progression in a transgenic mouse model. PMID:30250560
Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis. PMID:30250075
Does Axl have potential as a therapeutic target in pancreatic cancer? PMID:30244621
SMC1A is associated with radioresistance in prostate cancer and acts by regulating epithelial-mesenchymal transition and cancer stem-like properties. PMID:30242889
The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model. PMID:30241549
Lack of APC somatic mutation is associated with early-onset colorectal cancer in African Americans. PMID:30239619
The endothelial glycocalyx anchors von Willebrand factor fibers to the vascular endothelium. PMID:30237293
Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment. PMID:30237173
Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas. PMID:30236127
Absence of AIF1L contributes to cell migration and a poor prognosis of breast cancer. PMID:30233209
Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression. PMID:30228209
Early Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma. PMID:30227407
Targeting LRP8 inhibits breast cancer stem cells in triple-negative breast cancer. PMID:30227220
ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner. PMID:30226859
Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular stress. PMID:30224719
Mutational processes shape the landscape of TP53 mutations in human cancer. PMID:30224644
TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM. PMID:30221069
Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer. PMID:30220976
A pan-cancer atlas of cancer hallmark-associated candidate driver lncRNAs. PMID:30216655
Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival. PMID:30214626
A TOP2A-derived cancer panel drives cancer progression in papillary renal cell carcinoma. PMID:30214555
Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids. PMID:30213835
Genomics of adult and pediatric solid tumors. PMID:30210910
Multifaceted regulation and functions of replication factor C family in human cancers. PMID:30210909
Integrative Histologic and Bioinformatics Analysis of BIRC5/Survivin Expression in Oral Squamous Cell Carcinoma. PMID:30205554
BAP1 links metabolic regulation of ferroptosis to tumour suppression. PMID:30202049
PTPRT and PTPRD Deleterious Mutations and Deletion Predict Bevacizumab Resistance in Metastatic Colorectal Cancer Patients. PMID:30200630
The p53 Pathway in Glioblastoma. PMID:30200436
ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer. PMID:30200227
P4HA3 is Epigenetically Activated by Slug in Gastric Cancer and its Deregulation is Associated With Enhanced Metastasis and Poor Survival. PMID:30198421
POLE gene hotspot mutations in advanced pancreatic cancer. PMID:30194485
Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer. PMID:30194340
Expression of the Vesicular Monoamine Transporter Gene Solute Carrier Family 18 Member 1 (SLC18A1) in Lung Cancer. PMID:30194079
Oncogene-directed small molecule inhibitors for the treatment of cutaneous melanoma. PMID:30190843
Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells. PMID:30190481
The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer. PMID:30188895
Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis. PMID:30188888
Signaling by discoidin domain receptor 1 in cancer metastasis. PMID:30187813
Expression profiling of ubiquitin-related genes in LKB1 mutant lung adenocarcinoma. PMID:30185829
Characterization of Mutations in the Mitochondrial Encoded Electron Transport Chain Complexes in Acute Myeloid Leukemia. PMID:30185817
Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. PMID:30185663
Structural insights into the functional diversity of the CDK-cyclin family. PMID:30185601
Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer. PMID:30181917
Identification of key pathways and genes in response to trastuzumab treatment in breast cancer using bioinformatics analysis. PMID:30181805
The prognostic effects of somatic mutations in ER-positive breast cancer. PMID:30181556
GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression. PMID:30181547
Targeting Raf Kinase Inhibitory Protein Regulation and Function. PMID:30181452
Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner. PMID:30177832
Genomic case report of a low grade bladder tumor metastasis to lung. PMID:30176882
Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. PMID:30174241
Mutations, Differential Gene Expression, and Chimeric Transcripts in Esophageal Squamous Cell Carcinoma Show High Heterogeneity. PMID:30172240
Prevalence of DNA repair gene mutations in localized prostate cancer according to clinical and pathologic features: association of Gleason score and tumor stage. PMID:30171229
Rare but Recurrent ROS1 Fusions Resulting From Chromosome 6q22 Microdeletions are Targetable Oncogenes in Glioma. PMID:30171048
Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT). PMID:30170559
DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity. PMID:30167090
Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors. PMID:30166553
Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains. PMID:30166540
Fractalis: a scalable open-source service for platform-independent interactive visual analysis of biomedical data. PMID:30165440
The Ras-related gene ERAS is involved in human and murine breast cancer. PMID:30158566
IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization. PMID:30154549
PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer. PMID:30154144
HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma. PMID:30153855
Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors. PMID:30150660
Current Landscape of Targeted Therapies for Hormone-Receptor Positive, HER2 Negative Metastatic Breast Cancer. PMID:30148117
How does inflammation drive mutagenesis in colorectal cancer? PMID:30147278
Regulation and modulation of PTEN activity. PMID:30145641
Recent advances in prostate cancer research: large-scale genomic analyses reveal novel driver mutations and DNA repair defects. PMID:30135717
DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride. PMID:30132517
BCMA (TNFRSF17) Induces APRIL and BAFF Mediated Breast Cancer Cell Stemness. PMID:30131941
Increased HSF1 expression predicts shorter disease-specific survival of prostate cancer patients following radical prostatectomy. PMID:30131848
Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells. PMID:30131529
Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer. PMID:30128035
High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma. PMID:30127967
The knockdown of the Mediator complex subunit MED15 restrains urothelial bladder cancer cells' malignancy. PMID:30127891
Skp2 expression has different clinicopathological and prognostic implications in lung adenocarcinoma and squamous cell carcinoma. PMID:30127874
Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma. PMID:30127394
Metastatic cells are preferentially vulnerable to lysosomal inhibition. PMID:30127018
p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2. PMID:30126895
Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance. PMID:30126203
Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma. PMID:30125264
Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer. PMID:30123134
Detection of Molecular Alterations in Taiwanese Patients with Medullary Thyroid Cancer Using Whole-Exome Sequencing. PMID:30120715
Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer. PMID:30115973
Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells. PMID:30112110
Novel clinicopathological and molecular characterization of metanephric adenoma: a study of 28 cases. PMID:30111351
A New Strategy to Uncover the Anticancer Mechanism of Chinese Compound Formula by Integrating Systems Pharmacology and Bioinformatics. PMID:30108661
Identification of an oncogenic network with prognostic and therapeutic value in prostate cancer. PMID:30108134
Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes. PMID:30107825
Increased levels of RECQ5 shift DNA repair from canonical to alternative pathways. PMID:30107528
Endogenous HIF2A reporter systems for high-throughput functional screening. PMID:30104738
The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor. PMID:30104711
Targeted Therapies in Type II Endometrial Cancers: Too Little, but Not Too Late. PMID:30104481
Germline and Somatic NF1 Alterations Are Linked to Increased HER2 Expression in Breast Cancer. PMID:30104415
A pan-cancer study of the transcriptional regulation of uricogenesis in human tumours: pathological and pharmacological correlates. PMID:30104401
Rethinking Gamma-secretase Inhibitors for Treatment of Non-small-Cell Lung Cancer: Is Notch the Target? PMID:30104200
Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting. PMID:30103702
A novel mechanism of SRRM4 in promoting neuroendocrine prostate cancer development via a pluripotency gene network. PMID:30100395
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures. PMID:30100185
Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis. PMID:30099850
Identification of UAP1L1 as a critical factor for protein O-GlcNAcylation and cell proliferation in human hepatoma cells. PMID:30097606
Downregulation of CEACAM6 gene expression in laryngeal squamous cell carcinoma is an effect of DNA hypermethylation and correlates with disease progression. PMID:30094098
Positive crosstalk between EGFR and the TF-PAR2 pathway mediates resistance to cisplatin and poor survival in cervical cancer. PMID:30093972
Transcriptomic analysis of CIC and ATXN1L reveal a functional relationship exploited by cancer. PMID:30093628
Survival in males with glioma and gastric adenocarcinoma correlates with mutant p53 residual transcriptional activity. PMID:30089713
The Cancer Omics Atlas: an integrative resource for cancer omics annotations. PMID:30089500
Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients. PMID:30088263
Mutations in NOTCH1 and nucleotide excision repair genes are correlated with prognosis of hepatitis B virus-associated hepatocellular carcinoma. PMID:30087708
Essential role of MED1 in the transcriptional regulation of ER-dependent oncogenic miRNAs in breast cancer. PMID:30087366
Integrative analysis of the inter-tumoral heterogeneity of triple-negative breast cancer. PMID:30087365
Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer. PMID:30086764
Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer. PMID:30078843
RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers. PMID:30078441
CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools. PMID:30076241
Sno-derived RNAs are prevalent molecular markers of cancer immunity. PMID:30072739
Familial Cancer Variant Prioritization Pipeline version 2 (FCVPPv2) applied to a papillary thyroid cancer family. PMID:30072699
Exploring the OncoGenomic Landscape of cancer. PMID:30071882
Role of Pseudogenes in Tumorigenesis. PMID:30071685
Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies. PMID:30067989
CLEC3B is downregulated and inhibits proliferation in clear cell renal cell carcinoma. PMID:30066941
PATRI, a Genomics Data Integration Tool for Biomarker Discovery. PMID:30065933
TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727. PMID:30065235
ER stress-related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer. PMID:30063110
Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study. PMID:30062862
Central role of autophagic UVRAG in melanogenesis and the suntan response. PMID:30061422
Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). PMID:30061297
CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest. PMID:30061045
Monitoring Immune Checkpoint Regulators as Predictive Biomarkers in Hepatocellular Carcinoma. PMID:30057891
Targeted Next-Generation Sequencing Identifies Actionable Targets in Estrogen Receptor Positive and Estrogen Receptor Negative Endometriod Endometrial Cancer. PMID:30057548
BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery. PMID:30053270
Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. PMID:30053102
Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing. PMID:30052636
Co-inhibition of mTORC1, HDAC and ESR1α retards the growth of triple-negative breast cancer and suppresses cancer stem cells. PMID:30050079
A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network. PMID:30049386
The mutational landscape of recurrent versus nonrecurrent human papillomavirus-related oropharyngeal cancer. PMID:30046007
The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma. PMID:30046005
Upregulation of PD-L1 predicts poor prognosis and is associated with miR-191-5p dysregulation in colon adenocarcinoma. PMID:30045644
Nuclear receptor ERRα and transcription factor ERG form a reciprocal loop in the regulation of TMPRSS2:ERG fusion gene in prostate cancer. PMID:30042415
Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer. PMID:30042390
Regulation of the oncogenic phenotype by the nuclear body protein ZC3H8. PMID:30041613
CDK4/6 inhibition in breast cancer: current practice and future directions. PMID:30038670
Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation. PMID:30037981
Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer. PMID:30037904
Molecular Portrait of Hypoxia in Breast Cancer: A Prognostic Signature and Novel HIF-Regulated Genes. PMID:30037853
RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer. PMID:30037330
Computational Approaches to Prioritize Cancer Driver Missense Mutations. PMID:30037003
PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress. PMID:30032250
Construction of a set of novel and robust gene expression signatures predicting prostate cancer recurrence. PMID:30024105
A Review of FOXI3 Regulation of Development and Possible Roles in Cancer Progression and Metastasis. PMID:30018953
Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes. PMID:30018742
A multiomics analysis of S100 protein family in breast cancer. PMID:30018736
Integrated genetic and epigenetic analysis of myxofibrosarcoma. PMID:30018380
Data Integration for Future Medicine (DIFUTURE). PMID:30016812
Downregulation of miR‑486‑5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing. PMID:30015845
TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins. PMID:30013069
CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade. PMID:30012853
Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss? PMID:30009155
Identification and validation of a Hedgehog pathway-based 3-gene prognostic signature for gastric cancers. PMID:30008928
Exosomal zinc transporter ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer. PMID:30007115
Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations. PMID:30006355
Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton. PMID:30005669
An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression. PMID:30004690
Identification and validation of SRY-box containing gene family member SOX30 methylation as a prognostic and predictive biomarker in myeloid malignancies. PMID:30002740
Tumor Suppressor Activity of Selenbp1, a Direct Nkx2-1 Target, in Lung Adenocarcinoma. PMID:30002193
Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers. PMID:29997511
KM-express: an integrated online patient survival and gene expression analysis tool for the identification and functional characterization of prognostic markers in breast and prostate cancers. PMID:29992322
FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium. PMID:29991799
Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers. PMID:29991691
LINC00152 Promotes Invasion through a 3'-Hairpin Structure and Associates with Prognosis in Glioblastoma. PMID:29991527
Involvement of anti-tumor miR-124-3p and its targets in the pathogenesis of pancreatic ductal adenocarcinoma: direct regulation of ITGA3 and ITGB1 by miR-124-3p. PMID:29988949
Nuclear factor-κB p65 regulates glutaminase 1 expression in human hepatocellular carcinoma. PMID:29988727
Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy. PMID:29988316
Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance. PMID:29987135
PBRM1 bromodomains variably influence nucleosome interactions and cellular function. PMID:29986887
Tongue carcinoma in young adults: a review of the literature. PMID:29984792
Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance. PMID:29983888
Prostate cancer susceptibility gene HIST1H1A is a modulator of androgen receptor signaling and epithelial to mesenchymal transition. PMID:29983878
Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model. PMID:29981811
GABA promotes gastrin-releasing peptide secretion in NE/NE-like cells: Contribution to prostate cancer progression. PMID:29980692
Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells. PMID:29980625
Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer. PMID:29980571
Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer. PMID:29975776
PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition. PMID:29975751
Eosinophilic Solid and Cystic (ESC) Renal Cell Carcinomas Harbor TSC Mutations: Molecular Analysis Supports an Expanding Clinicopathologic Spectrum. PMID:29975249
Subependymal giant cell astrocytoma-like astrocytoma: a neoplasm with a distinct phenotype and frequent neurofibromatosis type-1-association. PMID:29973652
Aberrant Promoter Methylation of YAP Gene and its Subsequent Downregulation in Indian Breast Cancer Patients. PMID:29970036
Oncogenic c-terminal cyclin D1 (CCND1) mutations are enriched in endometrioid endometrial adenocarcinomas. PMID:29969496
Regulation of antitumor miR-144-5p targets oncogenes: Direct regulation of syndecan-3 and its clinical significance. PMID:29968393
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia. PMID:29967349
Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis. PMID:29967250
Combining Pathway Identification and Breast Cancer Survival Prediction via Screening-Network Methods. PMID:29963073
Identification of an enhancer region within the TP63/LEPREL1 locus containing genetic variants associated with bladder cancer risk. PMID:29956121
Association Between the Oligomeric Status of p53 and Clinical Outcomes in Li-Fraumeni Syndrome. PMID:29955864
MiR-146a promotes the asymmetric division and inhibits the self-renewal ability of breast cancer stem-like cells via indirect upregulation of Let-7. PMID:29954239
RUMI is a novel negative prognostic marker and therapeutic target in non-small-cell lung cancer. PMID:29953591
Profiles of Radioresistance Mechanisms in Prostate Cancer. PMID:29953367
ETS1 is associated with cisplatin resistance through IKKα/NF-κB pathway in cell line MDA-MB-231. PMID:29950928
Biomarker discovery by integrated joint non-negative matrix factorization and pathway signature analyses. PMID:29950679
Long Noncoding RNAs in Colorectal Adenocarcinoma; an in silico Analysis. PMID:29948619
Molecular classification and subtype-specific characterization of skin cutaneous melanoma by aggregating multiple genomic platform data. PMID:29948145
Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant. PMID:29945995
MuvB: A Key to Cell Cycle Control in Ovarian Cancer. PMID:29942794
LncRNA ITGB2-AS1 Could Promote the Migration and Invasion of Breast Cancer Cells through Up-Regulating ITGB2. PMID:29941860
O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1. PMID:29941490
Gene expression profile and cancer-associated pathways linked to progesterone receptor isoform a (PRA) predominance in transgenic mouse mammary glands. PMID:29940887
Role of RNF20 in cancer development and progression - a comprehensive review. PMID:29934362
Connexin 43 C-terminus directly inhibits the hyperphosphorylation of Akt/ERK through protein-protein interactions in glioblastoma. PMID:29931708
Potential candidate treatment agents for targeting of cholangiocarcinoma identified by gene expression profile analysis. PMID:29930804
Frequent epigenetic alterations in polycomb repressive complex 2 in osteosarcoma cell lines. PMID:29930752
A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4. PMID:29930202
Anti-tumor roles of both strands of the miR-455 duplex: their targets SKA1 and SKA3 are involved in the pathogenesis of renal cell carcinoma. PMID:29928475
Novel insights into biomarkers associated with renal cell carcinoma. PMID:29928389
The ERBB network facilitates KRAS-driven lung tumorigenesis. PMID:29925636
Upregulation of the EMT marker vimentin is associated with poor clinical outcome in acute myeloid leukemia. PMID:29925392
Molecular Characterization and Putative Pathogenic Pathways of Tuberous Sclerosis Complex-Associated Renal Cell Carcinoma. PMID:29925043
Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas. PMID:29909548
Daxx Functions Are p53-Independent In Vivo. PMID:29903771
Low expression of KCNN3 may affect drug resistance in ovarian cancer. PMID:29901154
Dataset describing the development, optimization and application of SRM/MRM based targeted proteomics strategy for quantification of potential biomarkers of EGFR TKI sensitivity. PMID:29900338
The immune checkpoint protein PD-L1 induces and maintains regulatory T cells in glioblastoma. PMID:29900065
Complex pattern of immune evasion in MSI colorectal cancer. PMID:29900056
High Densities of Tumor-Associated Plasma Cells Predict Improved Prognosis in Triple Negative Breast Cancer. PMID:29899747
BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer. PMID:29898809
Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer. PMID:29892061
Analysis of differentially expressed genes, clinical value and biological pathways in prostate cancer. PMID:29887958
Precision Medicine in Head and Neck Cancer: Myth or Reality? PMID:29887732
Expression and prognostic value of cell-cycle-associated genes in gastric adenocarcinoma. PMID:29884122
Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways. PMID:29875996
Turning Uridines around: Role of rRNA Pseudouridylation in Ribosome Biogenesis and Ribosomal Function. PMID:29874862
Identification and targeting of an FGFR fusion in a pediatric thalamic "central oligodendroglioma". PMID:29872711
Network-based machine learning and graph theory algorithms for precision oncology. PMID:29872707
Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis. PMID:29872345
Elevated expression of podoplanin and its clinicopathological, prognostic, and therapeutic values in squamous non-small cell lung cancer. PMID:29872344
Gene expression and prognosis of NOX family members in gastric cancer. PMID:29872318
Transcriptomic analysis and mutational status of IDH1 in paired primary-recurrent intrahepatic cholangiocarcinoma. PMID:29871612
Discovering mutated driver genes through a robust and sparse co-regularized matrix factorization framework with prior information from mRNA expression patterns and interaction network. PMID:29871594
RNA-Seq of Circulating Tumor Cells in Stage II-III Breast Cancer. PMID:29868978
Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway. PMID:29866109
RankProd Combined with Genetic Algorithm Optimized Artificial Neural Network Establishes a Diagnostic and Prognostic Prediction Model that Revealed C1QTNF3 as a Biomarker for Prostate Cancer. PMID:29861410
Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p. PMID:29859298
Targeting Rac and Cdc42 GTPases in Cancer. PMID:29858187
Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors. PMID:29858058
LINC00857 expression predicts and mediates the response to platinum-based chemotherapy in muscle-invasive bladder cancer. PMID:29856124
LRP5 regulates the expression of STK40, a new potential target in triple-negative breast cancers. PMID:29854300
Splicing dysregulation as a driver of breast cancer. PMID:29848666
IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer. PMID:29847788
Bronchiolar Adenoma: Expansion of the Concept of Ciliated Muconodular Papillary Tumors With Proposal for Revised Terminology Based on Morphologic, Immunophenotypic, and Genomic Analysis of 25 Cases. PMID:29846186
High expression of long non-coding RNA MALAT1 in breast cancer is associated with poor relapse-free survival. PMID:29845475
Cofilin-1 levels and intracellular localization are associated with melanoma prognosis in a cohort of patients. PMID:29844875
PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma. PMID:29844863
RANK-c attenuates aggressive properties of ER-negative breast cancer by inhibiting NF-κB activation and EGFR signaling. PMID:29844572
Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate. PMID:29844571
Whole-Genome Sequencing in Cancer. PMID:29844223
TMPRSS2-ERG Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in PTEN and TP53-Mutated Prostate Cancer. PMID:29844131
Exploration of the molecular mechanisms of cervical cancer based on mRNA expression profiles and predicted microRNA interactions. PMID:29805632
Downregulation of FOXP2 promotes breast cancer migration and invasion through TGFβ/SMAD signaling pathway. PMID:29805593
Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth. PMID:29802348
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma. PMID:29802247
Association of increased primary breast tumor AGR2 with decreased disease-specific survival. PMID:29796176
Identification of Biological Targets of Therapeutic Intervention for Hepatocellular Carcinoma by Integrated Bioinformatical Analysis. PMID:29795057
Massively parallel sequencing analysis of mucinous ovarian carcinomas: genomic profiling and differential diagnoses. PMID:29793804
Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase in Adrenocortical Carcinoma. PMID:29790920
FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells. PMID:29789392
Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy. PMID:29785026
DARPP-32 and t-DARPP promote non-small cell lung cancer growth through regulation of IKKα-dependent cell migration. PMID:29782621
PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia. PMID:29774127
A new method of identifying glioblastoma subtypes and creation of corresponding animal models. PMID:29769617
Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability. PMID:29769258
Predicting hepatocellular carcinoma through cross-talk genes identified by risk pathways. PMID:29765536
The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications. PMID:29757368
KRAS mutation and epithelial-macrophage interplay in pancreatic neoplastic transformation. PMID:29756386
Comprehensive analysis of the clinical significance and prospective molecular mechanisms of differentially expressed autophagy-related genes in thyroid cancer. PMID:29749543
TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma. PMID:29749538
Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis. PMID:29748619
An integrated view of the role of miR-130b/301b miRNA cluster in prostate cancer. PMID:29744254
The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia. PMID:29742019
Genetic and Epigenetic Features of Rapidly Progressing IDH-Mutant Astrocytomas. PMID:29741737
PTEN Regulates Nonhomologous End Joining By Epigenetic Induction of NHEJ1/XLF. PMID:29739874
Elevated serum RAS p21 is an independent prognostic factor in metastatic breast cancer. PMID:29739347
Whole-Exome Sequencing of Sinonasal Small Cell Carcinoma Arising within a Papillary Schneiderian Carcinoma In Situ. PMID:29734873
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. PMID:29733835
Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma. PMID:29728763
Robust genomic copy number predictor of pan cancer metastasis. PMID:29725504
Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors. PMID:29725351
Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system. PMID:29721165
Soluble CD146 is a predictive marker of pejorative evolution and of sunitinib efficacy in clear cell renal cell carcinoma. PMID:29721091
Protein arginine methyltransferase 8 gene enhances the colon cancer stem cell (CSC) function by upregulating the pluripotency transcription factor. PMID:29721049
Molecular Landscape of ERBB2/ERBB3 Mutated Colorectal Cancer. PMID:29718453
VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin. PMID:29717062
Cell division cycle 7 is a potential therapeutic target in oral squamous cell carcinoma and is regulated by E2F1. PMID:29713760
Regulation of DNA damage repair and lipid uptake by CX3CR1 in epithelial ovarian carcinoma. PMID:29712888
Targeting DNA Methyltranferases in Urological Tumors. PMID:29706891
ACTN4 regulates the stability of RIPK1 in melanoma. PMID:29706658
In Silico and In Vitro Analyses of LncRNAs as Potential Regulators in the Transition from the Epithelioid to Sarcomatoid Histotype of Malignant Pleural Mesothelioma (MPM). PMID:29701689
The Correlation Between the Immune and Epithelial-Mesenchymal Transition Signatures Suggests Potential Therapeutic Targets and Prognosis Prediction Approaches in Kidney Cancer. PMID:29700419
New perspectives: systems medicine in cardiovascular disease. PMID:29699591
CAS-viewer: web-based tool for splicing-guided integrative analysis of multi-omics cancer data. PMID:29697367
Ankyrin repeat and single KH domain 1 (ANKHD1) drives renal cancer cell proliferation via binding to and altering a subset of miRNAs. PMID:29695508
EGFR L861Q Mutation in a Metastatic Solid-pseudopapillary Neoplasm of the Pancreas. PMID:29695402
Copy number changes at 8p11-12 predict adverse clinical outcome and chemo- and radiotherapy response in breast cancer. PMID:29682206
Combination of isocitrate dehydrogenase 1 (IDH1) mutation and podoplanin expression in brain tumors identifies patients at high or low risk of venous thromboembolism. PMID:29676036
High G2 and S-phase expressed 1 expression promotes acral melanoma progression and correlates with poor clinical prognosis. PMID:29660787
Quantitative targeted proteomic analysis of potential markers of tyrosine kinase inhibitor (TKI) sensitivity in EGFR mutated lung adenocarcinoma. PMID:29660496
oncoNcRNA: A Web Portal for Exploring the Non-Coding RNAs with Oncogenic Potentials in Human Cancers. PMID:29657279
Genomic Instability Promoted by Overexpression of Mismatch Repair Factors in Yeast: A Model for Understanding Cancer Progression. PMID:29654124
Systematic reconstruction of autism biology from massive genetic mutation profiles. PMID:29651456
Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma. PMID:29650805
Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer. PMID:29649003
Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior. PMID:29648538
Replication-incompetent gammaretroviral and lentiviral vector-based insertional mutagenesis screens identify prostate cancer progression genes. PMID:29643985
Epigenome-wide association study of metabolic syndrome in African-American adults. PMID:29643945
H19 overexpression promotes leukemogenesis and predicts unfavorable prognosis in acute myeloid leukemia. PMID:29643943
Contextual determinants of TGFβ action in development, immunity and cancer. PMID:29643418
T cell-induced CSF1 promotes melanoma resistance to PD1 blockade. PMID:29643229
Non-Coding Transcript Heterogeneity in Mesothelioma: Insights from Asbestos-Exposed Mice. PMID:29641489
The arachidonic acid metabolism protein-protein interaction network and its expression pattern in esophageal diseases. PMID:29636881
Disruption of NSD1 in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation. PMID:29636367
Identification of an Unfavorable Immune Signature in Advanced Lung Tumors from Nrf2-Deficient Mice. PMID:29634345
Genetic alterations and PIK3CA gene mutations and amplifications analysis in cervical cancer by racial groups in the United States. PMID:29623014
Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer. PMID:29622797
NFκB regulates p21 expression and controls DNA damage-induced leukemic differentiation. PMID:29622796
MORC2, a novel oncogene, is upregulated in liver cancer and contributes to proliferation, metastasis and chemoresistance. PMID:29620211
Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner. PMID:29619216
Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer. PMID:29618387
A comprehensive analysis of the predicted targets of miR-642b-3p associated with the long non-coding RNA HOXA11-AS in NSCLC cells. PMID:29616096
Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers. PMID:29615613
Finding cancer driver mutations in the era of big data research. PMID:29611034
Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making. PMID:29610392
Regulation of NCAPG by miR-99a-3p (passenger strand) inhibits cancer cell aggressiveness and is involved in CRPC. PMID:29608247
Concomitant BCORL1 and BRAF Mutations in Vemurafenib-Resistant Melanoma Cells. PMID:29605720
The Role of Transcription Factor YY1 in the Biology of Cancer. PMID:29604933
Modelling cost-effectiveness of a biomarker-based approach to neoadjuvant chemotherapy for muscle-invasive bladder cancer. PMID:29603871
Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma. PMID:29599922
PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells. PMID:29599917
Dissecting the Mutational Landscape of Cutaneous Melanoma: An Omic Analysis Based on Patients from Greece. PMID:29596374
UBE2C Is a Transcriptional Target of the Cell Cycle Regulator FOXM1. PMID:29596365
MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis. PMID:29594759
RNA-splicing factor SART3 regulates translesion DNA synthesis. PMID:29590477
The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth. PMID:29588411
Comprehensive genomic profiling aids in treatment of a metastatic endometrial cancer. PMID:29588307
miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis. PMID:29587866
Integrated Oncogenomic Profiling of Copy Numbers and Gene Expression in Lung Adenocarcinomas without EGFR Mutations or ALK Fusion. PMID:29581789
IDH1/2 Mutations Predict Shorter Survival in Chondrosarcoma. PMID:29581779
Genome-wide Association Study (GWAS) of Germline Copy Number Variations (CNVs) Reveal Genetic Risks of Prostate Cancer in Chinese population. PMID:29581771
The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer. PMID:29578365
Poly ADP-ribose polymerase-1 as a potential therapeutic target in Merkel cell carcinoma. PMID:29570891
Molecular profiling of ALDH1+ colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress pro-survival signalling pathways. PMID:29568377
Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer. PMID:29566768
The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours. PMID:29566741
FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma. PMID:29565465
The protein histidine phosphatase LHPP is a tumour suppressor. PMID:29562234
Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis. PMID:29562167
Meta-analysis of CDKN2A methylation to find its role in prostate cancer development and progression, and also to find the effect of CDKN2A expression on disease-free survival (PRISMA). PMID:29561434
QSurface: fast identification of surface expression markers in cancers. PMID:29560830
Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer. PMID:29560115
Effect of CCL5 expression in the recruitment of immune cells in triple negative breast cancer. PMID:29559701
MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation. PMID:29556384
PRL-3 is a potential glioblastoma prognostic marker and promotes glioblastoma progression by enhancing MMP7 through the ERK and JNK pathways. PMID:29556339
Epigenetic restriction of Hippo signaling by MORC2 underlies stemness of hepatocellular carcinoma cells. PMID:29555977
SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer. PMID:29547122
An integrated approach identifies new oncotargets in melanoma. PMID:29545914
Investigating a multigene prognostic assay based on significant pathways for Luminal A breast cancer through gene expression profile analysis. PMID:29545900
Expression of reactive species related genes is associated with patient survival in luminal B breast cancer. PMID:29545070
The curious case of Gαs gain-of-function in neoplasia. PMID:29544460
Discovery and validation of a glioblastoma co-expressed gene module. PMID:29541392
Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells. PMID:29541196
CD47 expression in Epstein-Barr virus-associated gastric carcinoma: coexistence with tumor immunity lowering the ratio of CD8+/Foxp3+ T cells. PMID:29536167
Targeting loss of the Hippo signaling pathway in NF2-deficient papillary kidney cancers. PMID:29535838
Nutlin-3a as a novel anticancer agent for adrenocortical carcinoma with CTNNB1 mutation. PMID:29532999
DNA Damage Response in Prostate Cancer. PMID:29530944
CD117/c-kit in Cancer Stem Cell-Mediated Progression and Therapeutic Resistance. PMID:29518044
TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer. PMID:29515762
Expression of TDRD9 in a subset of lung carcinomas by CpG island hypomethylation protects from DNA damage. PMID:29515758
Protein kinase C: perfectly balanced. PMID:29513138
Identification of COL4A1 as a potential gene conferring trastuzumab resistance in gastric cancer based on bioinformatics analysis. PMID:29512712
DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA. PMID:29509408
LRP1 expression in colon cancer predicts clinical outcome. PMID:29507659
Oncogenic BRAF mutations and p16 expression in melanocytic nevi and melanoma in the Polish population. PMID:29507566
The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers. PMID:29506079
A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance. PMID:29505315
Impact of Phosphoproteomics in the Era of Precision Medicine for Prostate Cancer. PMID:29503809
Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer. PMID:29497091
Carbonic Anhydrases: Role in pH Control and Cancer. PMID:29495652
The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer. PMID:29495625
Intrahepatic cholangiocarcinoma: can imaging phenotypes predict survival and tumor genetics? PMID:29492607
Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells. PMID:29492203
Pulling the BAX trigger for tumor cell death. PMID:29492188
UBASH3B-mediated silencing of the mitotic checkpoint: Therapeutic perspectives in cancer. PMID:29487893
Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma. PMID:29487705
The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection. PMID:29487696
Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression. PMID:29487338
ERK5 is activated by oncogenic BRAF and promotes melanoma growth. PMID:29483645
The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma. PMID:29481555
Epigenetic silencing of RNF144A expression in breast cancer cells through promoter hypermethylation and MBD4. PMID:29473320
Adhesion GPCRs in Kidney Development and Disease. PMID:29468160
Identification of the potential crucial genes in invasive ductal carcinoma using bioinformatics analysis. PMID:29467930
Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer. PMID:29465762
The transcriptional and mutational landscapes of lipid metabolism-related genes in colon cancer. PMID:29464044
GRK5 functions as an oncogenic factor in non-small-cell lung cancer. PMID:29463786
Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression. PMID:29463646
The Role of the Estrogen Pathway in the Tumor Microenvironment. PMID:29463044
The INO80 chromatin remodeler sustains metabolic stability by promoting TOR signaling and regulating histone acetylation. PMID:29462149
Diffuse gliomas classified by 1p/19q co-deletion, TERT promoter and IDH mutation status are associated with specific genetic risk loci. PMID:29460007
Role of BRCA Mutations in the Modulation of Response to Platinum Therapy. PMID:29459887
Recon3D enables a three-dimensional view of gene variation in human metabolism. PMID:29457794
Genomic Analysis Revealed New Oncogenic Signatures in TP53-Mutant Hepatocellular Carcinoma. PMID:29456550
SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer. PMID:29456503
The role of RICTOR downstream of receptor tyrosine kinase in cancers. PMID:29455662
Differential expression of the TWEAK receptor Fn14 in IDH1 wild-type and mutant gliomas. PMID:29453678
Metaplastic breast cancer in a patient with neurofibromatosis type 1 and somatic loss of heterozygosity. PMID:29449315
Dexamethasone-Mediated Upregulation of Calreticulin Inhibits Primary Human Glioblastoma Dispersal Ex Vivo. PMID:29443896
Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC). PMID:29440769
Targeting the MAPK Pathway in RAS Mutant Cancers. PMID:29440321
KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis. PMID:29440247
Oncogenic Kinase-Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem-like Cells. PMID:29440169
Lipid metabolism and lipophagy in cancer. PMID:29438712
Expression and function of nuclear receptor coactivator 4 isoforms in transformed endometriotic and malignant ovarian cells. PMID:29435183
Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma. PMID:29435132
Characterization and validation of potential therapeutic targets based on the molecular signature of patient-derived xenografts in gastric cancer. PMID:29433585
MethCNA: a database for integrating genomic and epigenomic data in human cancer. PMID:29433427
Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer. PMID:29430503
The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity. PMID:29429988
Comprehensive review of genetic factors contributing to head and neck squamous cell carcinoma development in low-risk, nontraditional patients. PMID:29427520
Immunohistochemically detected IDH1R132H mutation is rare and mostly heterogeneous in prostate cancer. PMID:29427004
Intragenic DNA methylation of PITX1 and the adjacent long non-coding RNA C5orf66-AS1 are prognostic biomarkers in patients with head and neck squamous cell carcinomas. PMID:29425237
Clinical outcomes and differential effects of PI3K pathway mutation in obese versus non-obese patients with cervical cancer. PMID:29423104
Inhibition of integrin β1-mediated oncogenic signalling by the antitumor microRNA-29 family in head and neck squamous cell carcinoma. PMID:29423074
Systematic analysis of gene expression alterations and clinical outcomes of STAT3 in cancer. PMID:29423040
Extracellular redox state shift: A novel approach to target prostate cancer invasion. PMID:29421238
Leveraging Genomics for Head and Neck Cancer Treatment. PMID:29420101
Impact of novel oncogenic pathways regulated by antitumor miR-451a in renal cell carcinoma. PMID:29417701
Mechanism of action of the atypical retinoid ST1926 in colorectal cancer: DNA damage and DNA polymerase α. PMID:29416919
CancerDiscover: an integrative pipeline for cancer biomarker and cancer class prediction from high-throughput sequencing data. PMID:29416792
SIRT1 contributes to neuroendocrine differentiation of prostate cancer. PMID:29416748
Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction. PMID:29416706
Cooperation between ZEB2 and Sp1 promotes cancer cell survival and angiogenesis during metastasis through induction of survivin and VEGF. PMID:29416649
The prognostic significance of nuclear expression of PHF2 and C/EBPα in clear cell renal cell carcinoma with consideration of adipogenic metabolic evolution. PMID:29416602
Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy. PMID:29416592
Mutational Profiling of Malignant Mesothelioma Revealed Potential Therapeutic Targets in EGFR and NRAS. PMID:29413759
MicroRNA-10b expression in breast cancer and its clinical association. PMID:29408861
Targeting the IL-6/JAK/STAT3 signalling axis in cancer. PMID:29405201
Recovery of Immunoglobulin VJ Recombinations from Pancreatic Cancer Exome Files Strongly Correlates with Reduced Survival. PMID:29404962
BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1. PMID:29402932
RNA-protein interaction detection in living cells. PMID:29400715
Cellular vaccination of MLH1-/- mice - an immunotherapeutic proof of concept study. PMID:29399413
Bromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune-environment. PMID:29399399
Mixed lineage kinase ZAK promotes epithelial-mesenchymal transition in cancer progression. PMID:29396440
High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer. PMID:29391527
G2S: a web-service for annotating genomic variants on 3D protein structures. PMID:29385402
Regulation of Cancer Stem Cell Metabolism by Secreted Frizzled-Related Protein 4 (sFRP4). PMID:29385093
Tumor exome sequencing and copy number alterations reveal potential predictors of intrinsic resistance to multi-targeted tyrosine kinase inhibitors. PMID:29383146
Overexpression of HSD17B4 exerts tumor suppressive function in adrenocortical carcinoma and is not associated with hormone excess. PMID:29383116
CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway. PMID:29383104
Development of a personalized therapeutic strategy for ERBB-gene-mutated cancers. PMID:29383036
Responses to crizotinib and disease monitoring with circulating tumor cells in lung adenocarcinoma patient with MET exon 14 skipping mutation: A case report. PMID:29381967
Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. PMID:29381681
Mitotically-Associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer. PMID:29378907
Genomic analysis of head and neck cancer cases from two high incidence regions. PMID:29377909
Fanconi anaemia and cancer: an intricate relationship. PMID:29376519
Cisplatin and Pemetrexed Activate AXL and AXL Inhibitor BGB324 Enhances Mesothelioma Cell Death from Chemotherapy. PMID:29375377
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma. PMID:29371990
Suppressor of fused (Sufu) promotes epithelial-mesenchymal transition (EMT) in cervical squamous cell carcinoma. PMID:29371981
MAEL contributes to gastric cancer progression by promoting ILKAP degradation. PMID:29371914
Bioinformatics-based identification of miR-542-5p as a predictive biomarker in breast cancer therapy. PMID:29371858
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors. PMID:29371290
Specific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors. PMID:29367883
A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer. PMID:29367767
Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production. PMID:29367762
miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis. PMID:29367737
HOXC8 promotes proliferation and migration through transcriptional up-regulation of TGFβ1 in non-small cell lung cancer. PMID:29367650
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. PMID:29364867
α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration. PMID:29361527
TcR-α recombinations in renal cell carcinoma exome files correlate with an intermediate level of T-cell exhaustion biomarkers. PMID:29361059
A core matrisome gene signature predicts cancer outcome. PMID:29360819
Immunogenomics: A Negative Prostate Cancer Outcome Associated with TcR-γ/δ Recombinations. PMID:29357011
Syndecan-1 Controls Lung Tumorigenesis by Regulating miRNAs Packaged in Exosomes. PMID:29355516
Hypermethylation of NF-κB-Activating Protein-Like (NKAPL) Promoter in Hepatocellular Carcinoma Suppresses Its Expression and Predicts a Poor Prognosis. PMID:29353445
A mutational signature associated with alcohol consumption and prognostically significantly mutated driver genes in esophageal squamous cell carcinoma. PMID:29351612
CCAT1 stimulation of the symmetric division of NSCLC stem cells through activation of the Wnt signalling cascade. PMID:29350683
Overexpression of adhesion molecules and barrier molecules is associated with differential infiltration of immune cells in non-small cell lung cancer. PMID:29348685
Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma. PMID:29348488
SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1. PMID:29348142
The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer. PMID:29346117
In colonic ρ0 (rho0) cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer. PMID:29344557
Identification of key pathways and genes in TP53 mutation acute myeloid leukemia: evidence from bioinformatics analysis. PMID:29343974
The protective role of DOT1L in UV-induced melanomagenesis. PMID:29343685
Splice Expression Variation Analysis (SEVA) for inter-tumor heterogeneity of gene isoform usage in cancer. PMID:29342249
Clinicopathological and prognostic significance of SDC1 overexpression in breast cancer. PMID:29340066
MCL-1 is a prognostic indicator and drug target in breast cancer. PMID:29339815
An orthotopic mouse model of gastric cancer invasion and metastasis. PMID:29339747
Kinase-independent function of E-type cyclins in liver cancer. PMID:29339491
IDH1/2 Mutations Sensitize Acute Myeloid Leukemia to PARP Inhibition and This Is Reversed by IDH1/2-Mutant Inhibitors. PMID:29339439
Making Use of Cancer Genomic Databases. PMID:29337373
Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-13C] Lactate. PMID:29330287
Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma. PMID:29330283
Lung fibroblasts promote metastatic colonization through upregulation of stearoyl-CoA desaturase 1 in tumor cells. PMID:29326439
Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer. PMID:29325444
Tumor purity quantification by clonal DNA methylation signatures. PMID:29325057
Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. PMID:29323272
Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis. PMID:29321207
Dual inhibition of Wnt and Yes-associated protein signaling retards the growth of triple-negative breast cancer in both mesenchymal and epithelial states. PMID:29316250
Precision Medicine in Children and Young Adults with Hematologic Malignancies and Blood Disorders: The Columbia University Experience. PMID:29312904
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma. PMID:29312802
Adipocyte-activated oxidative and ER stress pathways promote tumor survival in bone via upregulation of Heme Oxygenase 1 and Survivin. PMID:29311669
MRAS: A Close but Understudied Member of the RAS Family. PMID:29311130
Kras in Organoids. PMID:29311127
Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer. PMID:29311118
Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms. PMID:29309058
Long interspersed nuclear element-1 expression and retrotransposition in prostate cancer cells. PMID:29308092
Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer. PMID:29306329
Identification of specific feed-forward apoptosis mechanisms and associated higher survival rates for low grade glioma and lung squamous cell carcinoma. PMID:29305708
Transcription Factor and lncRNA Regulatory Networks Identify Key Elements in Lung Adenocarcinoma. PMID:29303984
Fibroblast growth factor receptor 1 and 3 expression is associated with regulatory PI3K/AKT kinase activity, as well as invasion and prognosis, in human laryngeal cancer. PMID:29299828
Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer. PMID:29298117
Incorporating biological prior knowledge for Bayesian learning via maximal knowledge-driven information priors. PMID:29297278
Interleukin enhancer-binding factor 3 and HOXC8 co-activate cadherin 11 transcription to promote breast cancer cells proliferation and migration. PMID:29296180
TFF1 hypermethylation and decreased expression in esophageal squamous cell carcinoma and histologically normal tumor surrounding esophageal cells. PMID:29296124
The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division. PMID:29295957
Context-Dependent Role of IKKβ in Cancer. PMID:29292732
Detection of somatic variants and EGFR mutations in cell-free DNA from non-small cell lung cancer patients by ultra-deep sequencing using the ion ampliseq cancer hotspot panel and droplet digital polymerase chain reaction. PMID:29290998
Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer. PMID:29290965
Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profile in Pancreatic Cancer Derived Exosomes Treated Dendritic Cells by Microarray Analysis. PMID:29290766
AKT3 drives adenoid cystic carcinoma development in salivary glands. PMID:29282901
Abnormal expression of TFIIIB subunits and RNA Pol III genes is associated with hepatocellular carcinoma. PMID:29276645
Methylation-regulated decommissioning of multimeric PP2A complexes. PMID:29273778
EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients. PMID:29272522
Usability and Suitability of the Omics-Integrating Analysis Platform tranSMART for Translational Research and Education. PMID:29270954
Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4. PMID:29269867
Overexpressed HSF1 cancer signature genes cluster in human chromosome 8q. PMID:29268782
VaDiR: an integrated approach to Variant Detection in RNA. PMID:29267927
The impact on high-grade serous ovarian cancer of obesity and lipid metabolism-related gene expression patterns: the underestimated driving force affecting prognosis. PMID:29266765
Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment. PMID:29262845
Chk1 modulates the interaction between myosin phosphatase targeting protein 1 (MYPT1) and protein phosphatase 1cβ (PP1cβ). PMID:29262732
Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53. PMID:29262616
Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model. PMID:29262598
Identification of SPOP related metabolic pathways in prostate cancer. PMID:29262542
PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression. PMID:29262329
Combination of palbociclib with enzalutamide shows in vitro activity in RB proficient and androgen receptor positive triple negative breast cancer cells. PMID:29261702
Recent advances in the management of non-small cell lung cancer. PMID:29259780
Genomic regression analysis of coordinated expression. PMID:29259170
High expression of FLT3 is a risk factor in leukemia. PMID:29257272
GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers. PMID:29255247
Development and validation of a targeted next generation DNA sequencing panel outperforming whole exome sequencing for the identification of clinically relevant genetic variants. PMID:29254223
Therapeutic potential of an anti-angiogenic multimodal biomimetic peptide in hepatocellular carcinoma. PMID:29254183
Accelerating Discovery of Functional Mutant Alleles in Cancer. PMID:29247016
High expression of lncRNA PVT1 independently predicts poor overall survival in patients with primary uveal melanoma. PMID:29244840
Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer. PMID:29242529
Ornithine decarboxylase as a therapeutic target for endometrial cancer. PMID:29240775
Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers. PMID:29235520
Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7. PMID:29235476
SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis. PMID:29234151
Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity. PMID:29233960
Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review. PMID:29230671
SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer. PMID:29229751
Genes with mutation significance were highly associated with the clinical pattern of patients with breast cancer. PMID:29228676
Subependymal giant cell astrocytomas in Tuberous Sclerosis Complex have consistent TSC1/TSC2 biallelic inactivation, and no BRAF mutations. PMID:29221145
CTD2 Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network. PMID:29220450
Advances in Text Mining and Visualization for Precision Medicine. PMID:29218914
Role of Dopamine Receptors in the Anticancer Activity of ONC201. PMID:29216597
Prediction of early-stage hepatocellular carcinoma using OncoScan chromosomal copy number aberration data. PMID:29209123
Robust method for identification of prognostic gene signatures from gene expression profiles. PMID:29208919
Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response. PMID:29208897
Identification and validation of a 44-gene expression signature for the classification of renal cell carcinomas. PMID:29208006
Integrative analysis to identify oncogenic gene expression changes associated with copy number variations of enhancer in ovarian cancer. PMID:29207666
Matrix metalloproteinase-1 expression in breast carcinoma: a marker for unfavorable prognosis. PMID:29207651
Cancer-mutated ribosome protein L22 (RPL22/eL22) suppresses cancer cell survival by blocking p53-MDM2 circuit. PMID:29207594
p-STAT3 in luminal breast cancer: Integrated RNA-protein pooled analysis and results from the BIG 2-98 phase III trial. PMID:29207087
Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous. PMID:29203670
Regulation of HMGB3 by antitumor miR-205-5p inhibits cancer cell aggressiveness and is involved in prostate cancer pathogenesis. PMID:29196733
Profiling of the transcriptional response to all-trans retinoic acid in breast cancer cells reveals RARE-independent mechanisms of gene expression. PMID:29192143
Genes co-amplified with ERBB2 or MET as novel potential cancer-promoting genes in gastric cancer. PMID:29190909
High bone marrow ID2 expression predicts poor chemotherapy response and prognosis in acute myeloid leukemia. PMID:29190891
Toll-like receptor expression in human non-small cell lung carcinoma: potential prognostic indicators of disease. PMID:29190881
Decreased KPNB1 Expression is Induced by PLK1 Inhibition and Leads to Apoptosis in Lung Adenocarcinoma. PMID:29187890
Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling. PMID:29187877
JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion. PMID:29186616
PKK deletion in basal keratinocytes promotes tumorigenesis after chemical carcinogenesis. PMID:29186361
The OncoPPi Portal: an integrative resource to explore and prioritize protein-protein interactions for cancer target discovery. PMID:29186335
Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription. PMID:29184031
Predicting cancer type from tumour DNA signatures. PMID:29183400
Investigation of fusion gene expression in HCT116 cells. PMID:29181107
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. PMID:29180628
Small-Cell Carcinomas of the Bladder and Lung Are Characterized by a Convergent but Distinct Pathogenesis. PMID:29180607
NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis. PMID:29176703
HOXC13 promotes proliferation of esophageal squamous cell carcinoma via repressing transcription of CASP3. PMID:29168599
Activating FGFR1 Mutations in Sporadic Pheochromocytomas. PMID:29159601
Structural analyses of key features in the KANK1·KIF21A complex yield mechanistic insights into the cross-talk between microtubules and the cell cortex. PMID:29158259
In silico and in vitro identification of inhibitory activities of sorafenib on histone deacetylases in hepatocellular carcinoma cells. PMID:29156785
Identification of potential tissue-specific cancer biomarkers and development of cancer versus normal genomic classifiers. PMID:29156751
Epigenetic silencing of tumor suppressor candidate 3 confers adverse prognosis in early colorectal cancer. PMID:29156678
β-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic β-catenin and MET. PMID:29152756
Functional network analysis of gene-phenotype connectivity associated with temozolomide. PMID:29152101
Salt bridges gate α-catenin activation at intercellular junctions. PMID:29142072
Copy number gains at chr3p25 and chr11p11 are associated with lymph node involvement and survival in muscle-invasive bladder tumors. PMID:29140994
Lack of both androgen receptor and forkhead box A1 (FOXA1) expression is a poor prognostic factor in estrogen receptor-positive breast cancers. PMID:29137314
Vinculin and filamin-C are two potential prognostic biomarkers and therapeutic targets for prostate cancer cell migration. PMID:29137275
LinkedOmics: analyzing multi-omics data within and across 32 cancer types. PMID:29136207
The Rho GTPase signalling pathway in urothelial carcinoma. PMID:29133936
Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer. PMID:29133620
An NRG Oncology/GOG study of molecular classification for risk prediction in endometrioid endometrial cancer. PMID:29132872
Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures. PMID:29130628
RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition. PMID:29127119
DNA methylation regulates TMEM16A/ANO1 expression through multiple CpG islands in head and neck squamous cell carcinoma. PMID:29123240
Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer. PMID:29122777
The Role of NRG1 in the Predisposition to Papillary Thyroid Carcinoma. PMID:29121253
Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion. PMID:29121062
KRAS Mutation in Gastric Cancer and Prognostication Associated with Microsatellite Instability Status. PMID:29116623
Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer. PMID:29112949
STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. PMID:29108249
Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells. PMID:29107110
Clinical Implications of NRAS Overexpression in Resectable Pancreatic Adenocarcinoma Patients. PMID:29101736
Combined Small Cell Carcinoma of the Lung: Is It a Single Entity? PMID:29101056
The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1. PMID:29100415
Genes encoding neuropeptide receptors are epigenetic markers in patients with head and neck cancer: a site-specific analysis. PMID:29100314
Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein. PMID:29100040
PAX5 gene as a novel methylation marker that predicts both clinical outcome and cisplatin sensitivity in esophageal squamous cell carcinoma. PMID:29099287
Percolation transition of cooperative mutational effects in colorectal tumorigenesis. PMID:29097710
Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer. PMID:29089489
Prevalence of Aflatoxin-Associated TP53R249S Mutation in Hepatocellular Carcinoma in Hispanics in South Texas. PMID:29089331
Neuropilin-1 is a glial cell line-derived neurotrophic factor receptor in glioblastoma. PMID:29088765
Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis. PMID:29088297
Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival. PMID:29088295
High ECT2 expression is an independent prognostic factor for poor overall survival and recurrence-free survival in non-small cell lung adenocarcinoma. PMID:29088286
Sortilin limits EGFR signaling by promoting its internalization in lung cancer. PMID:29084952
Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. PMID:29084603
ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells. PMID:29084210
C10orf116 Gene Copy Number Loss in Prostate Cancer: Clinicopathological Correlations and Prognostic Significance. PMID:29084195
Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications. PMID:29082853
SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. PMID:29081404
Vitamin D Receptor Signaling and Cancer. PMID:29080633
Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers. PMID:29073199
Resistance to checkpoint blockade therapy through inactivation of antigen presentation. PMID:29070816
Circulating tumor DNA detection in head and neck cancer: evaluation of two different detection approaches. PMID:29069814
SEECancer: a resource for somatic events in evolution of cancer genome. PMID:29069402
Mutation analysis and copy number alterations of KIF23 in non-small-cell lung cancer exhibiting KIF23 over-expression. PMID:29066916
Signaling by cell surface death receptors: Alterations in head and neck cancer. PMID:29066276
Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism. PMID:29063830
[Advances in the Transformation to Small Cell Lung Cancer from Non-small Cell Lung Cancer Following Acquired Drug-resistance to EGFR Tyrosine Kinase Inhibitors]. PMID:29061221
SBCDDB: Sleeping Beauty Cancer Driver Database for gene discovery in mouse models of human cancers. PMID:29059366
Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB. PMID:29059167
Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis. PMID:29057879
Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence. PMID:29055014
Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways. PMID:29054837
CANcer-specific Evaluation System (CANES): a high-accuracy platform, for preclinical single/multi-biomarker discovery. PMID:29050243
A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates. PMID:29049289
Gastric cancer: immunohistochemical classification of molecular subtypes and their association with clinicopathological characteristics. PMID:29046940
Protein Phosphatase Magnesium-Dependent 1δ (PPM1D) Expression as a Prognostic Marker in Adult Supratentorial Diffuse Astrocytic and Oligodendroglial Tumors. PMID:29046514
Clinical and molecular characterization of patients with cancer of unknown primary in the modern era. PMID:29045506
Role of N6-methyladenosine modification in cancer. PMID:29040886
Dysbindin promotes progression of pancreatic ductal adenocarcinoma via direct activation of PI3K. PMID:29040676
A novel machine learning approach reveals latent vascular phenotypes predictive of renal cancer outcome. PMID:29038551
CR2Cancer: a database for chromatin regulators in human cancer. PMID:29036683
Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. PMID:29035366
PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer. PMID:29034543
Identifying gene-gene interactions using penalized tensor regression. PMID:29034516
Genomic insights into head and neck cancer. PMID:29034103
A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events. PMID:29032073
MDM2 Antagonists Counteract Drug-Induced DNA Damage. PMID:29030058
Environment and bladder cancer: molecular analysis by interaction networks. PMID:29029427
Subtle Deregulation of the Wnt-Signaling Pathway Through Loss of Apc2 Reduces the Fitness of Intestinal Stem Cells. PMID:29027285
CAR T Therapy Targeting ICAM-1 Eliminates Advanced Human Thyroid Tumors. PMID:29025766
Mutational landscape of RNA-binding proteins in human cancers. PMID:29023197
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data. PMID:29021715
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. PMID:29021522
Metabolite Profiling Reveals the Glutathione Biosynthetic Pathway as a Therapeutic Target in Triple-Negative Breast Cancer. PMID:29021292
Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding. PMID:29018056
Targeting apoptosis in acute myeloid leukaemia. PMID:29017180
Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. PMID:29017059
Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment. PMID:29016864
Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation. PMID:29016808
Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors. PMID:28993411
ESRP1 is overexpressed in ovarian cancer and promotes switching from mesenchymal to epithelial phenotype in ovarian cancer cells. PMID:28991261
Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer. PMID:28984209
Unique protein expression signatures of survival time in kidney renal clear cell carcinoma through a pan-cancer screening. PMID:28984208
HOXC13 promotes proliferation of lung adenocarcinoma via modulation of CCND1 and CCNE1. PMID:28979806
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation. PMID:28978427
SLC2A2 (GLUT2) as a novel prognostic factor for hepatocellular carcinoma. PMID:28978124
Genetic profile and biological implication of PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) in human cancers: an analysis using The Cancer Genome Atlas. PMID:28978030
Genomic alterations in mucins across cancers. PMID:28978023
Overexpression of the E2F target gene CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer. PMID:28977935
NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization. PMID:28977907
Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer. PMID:28977839
BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing. PMID:28976962
Resources for Interpreting Variants in Precision Genomic Oncology Applications. PMID:28975082
Revisiting the impact of age and molecular subtype on overall survival after radiotherapy in breast cancer patients. PMID:28974723
Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation. PMID:28970512
Functional Impact of Chromatin Remodeling Gene Mutations and Predictive Signature for Therapeutic Response in Bladder Cancer. PMID:28970362
DNA-damage related genes and clinical outcome in hormone receptor positive breast cancer. PMID:28968952
Federation in genomics pipelines: techniques and challenges. PMID:28968781
Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence. PMID:28967919
Aurora-A-mediated phosphorylation of LKB1 compromises LKB1/AMPK signaling axis to facilitate NSCLC growth and migration. PMID:28967900
Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer. PMID:28966724
Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor. PMID:28963353
Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events. PMID:28959951
PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma. PMID:28951458
miR-367 stimulates Wnt cascade activation through degrading FBXW7 in NSCLC stem cells. PMID:28949784
miR-33a is a tumor suppressor microRNA that is decreased in prostate cancer. PMID:28947967
A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival. PMID:28947735
Estrogen Activation by Steroid Sulfatase Increases Colorectal Cancer Proliferation via GPER. PMID:28945888
Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. PMID:28945232
PRAS40 promotes NF-κB transcriptional activity through association with p65. PMID:28945219
Xanthine dehydrogenase downregulation promotes TGFβ signaling and cancer stem cell-related gene expression in hepatocellular carcinoma. PMID:28945217
Computational Approaches to Identify Genetic Interactions for Cancer Therapeutics. PMID:28941356
The FOXA2 transcription factor is frequently somatically mutated in uterine carcinosarcomas and carcinomas. PMID:28940304
Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation. PMID:28939681
Prostate Tumor Overexpressed-1 (PTOV1) promotes docetaxel-resistance and survival of castration resistant prostate cancer cells. PMID:28938627
Integrated molecular analysis of Tamoxifen-resistant invasive lobular breast cancer cells identifies MAPK and GRM/mGluR signaling as therapeutic vulnerabilities. PMID:28935545
MUC1-C promotes the suppressive immune microenvironment in non-small cell lung cancer. PMID:28932637
Methylation associated transcriptional repression of ELOVL5 in novel colorectal cancer cell lines. PMID:28931069
p16 Methylation was associated with the development, age, hepatic viruses infection of hepatocellular carcinoma, and p16 expression had a poor survival: A systematic meta-analysis (PRISMA). PMID:28930859
Overexpression of MUC1 and Genomic Alterations in Its Network Associate with Prostate Cancer Progression. PMID:28930697
Villi-specific Gene Expression Reveals Novel Prognostic Biomarkers in Multiple Human Cancers. PMID:28928868
Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer. PMID:28928458
HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers. PMID:28928286
MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression. PMID:28927893
Towards precision medicine: discovering novel gynecological cancer biomarkers and pathways using linked data. PMID:28927463
Associations of tumor suppressor SPARCL1 with cancer progression and prognosis. PMID:28927026
Loss of RUNX1 is associated with aggressive lung adenocarcinomas. PMID:28926105
Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling. PMID:28925397
Genomic analysis of exceptional responder to regorafenib in treatment-refractory metastatic rectal cancer: a case report and review of the literature. PMID:28915719
Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β. PMID:28915558
Identification of a novel p53 target, COL17A1, that inhibits breast cancer cell migration and invasion. PMID:28915553
Genomic Analysis of Tumor Microenvironment Immune Types across 14 Solid Cancer Types: Immunotherapeutic Implications. PMID:28912897
MPZL1 forms a signalling complex with GRB2 adaptor and PTPN11 phosphatase in HER2-positive breast cancer cells. PMID:28912526
Deconvolution of DNA methylation identifies differentially methylated gene regions on 1p36 across breast cancer subtypes. PMID:28912426
Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures. PMID:28912153
Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer. PMID:28904132
Analysis of the relationship between coexpression domains and chromatin 3D organization. PMID:28902867
Dual Strands of Pre-miR-149 Inhibit Cancer Cell Migration and Invasion through Targeting FOXM1 in Renal Cell Carcinoma. PMID:28902136
Screening and identification of key biomarkers in hepatocellular carcinoma: Evidence from bioinformatic analysis. PMID:28901457
TMEM16A/ANO1 Inhibits Apoptosis Via Downregulation of Bim Expression. PMID:28899969
Associations of two-pore domain potassium channels and triple negative breast cancer subtype in The Cancer Genome Atlas: systematic evaluation of gene expression and methylation. PMID:28899398
The genetic landscape of programmed death ligand-1 (PD-L1) alterations in head and neck cancer. PMID:28894827
Involvement of DPP9 in gene fusions in serous ovarian carcinoma. PMID:28893231
Targeting epidermal growth factor receptor co-dependent signaling pathways in glioblastoma. PMID:28892308
A system for detecting high impact-low frequency mutations in primary tumors and metastases. PMID:28892047
Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking. PMID:28892043
Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. PMID:28891816
Breast cancer risk and germline genomic profiling of women with neurofibromatosis type 1 who developed breast cancer. PMID:28891274
OncoKB: A Precision Oncology Knowledge Base. PMID:28890946
MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer. PMID:28888037
p53 gain-of-function mutations increase Cdc7-dependent replication initiation. PMID:28887320
Expression of SESN1, UHRF1BP1, and miR-377-3p as prognostic markers in mutated TP53 squamous cell carcinoma of the head and neck. PMID:28886272
Analysis of the whole transcriptome from gingivo-buccal squamous cell carcinoma reveals deregulated immune landscape and suggests targets for immunotherapy. PMID:28886030
Integrated expression profiles analysis reveals novel predictive biomarker in pancreatic ductal adenocarcinoma. PMID:28881752
Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma. PMID:28881735
BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1). PMID:28881656
A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas. PMID:28881577
Signatures derived from increase in SHARPIN gene copy number are associated with poor prognosis in patients with breast cancer. PMID:28879097
SPEN, a new player in primary cilia formation and cell migration in breast cancer. PMID:28877752
Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia. PMID:28870994
Dynamic Change of Transcription Pausing through Modulating NELF Protein Stability Regulates Granulocytic Differentiation. PMID:28868519
Clinical significance and prospective molecular mechanism of MALAT1 in pancreatic cancer exploration: a comprehensive study based on the GeneChip, GEO, Oncomine, and TCGA databases. PMID:28860807
PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer. PMID:28860563
A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer. PMID:28860486
Blood-brain barrier-adapted precision medicine therapy for pediatric brain tumors. PMID:28860053
A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes. PMID:28859688
Spatial and temporal epithelial ovarian cancer cell heterogeneity impacts Maraba virus oncolytic potential. PMID:28854921
Study on molecular mechanism of ANOS1 promoting development of colorectal cancer. PMID:28854193
Mutational heterogeneity in non-serous ovarian cancers. PMID:28852190
Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs. PMID:28850223
Identification of prognostic markers of high grade prostate cancer through an integrated bioinformatics approach. PMID:28849390
TP63 mutations are frequent in cutaneous melanoma, support UV etiology, but their role in melanomagenesis is unclear. PMID:28849221
Significance of the TMPRSS2:ERG gene fusion in prostate cancer. PMID:28849022
Discovering novel pharmacogenomic biomarkers by imputing drug response in cancer patients from large genomics studies. PMID:28847918
HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells. PMID:28842558
Lung adenocarcinoma: from molecular basis to genome-guided therapy and immunotherapy. PMID:28840016
The Neddylation Inhibitor Pevonedistat (MLN4924) Suppresses and Radiosensitizes Head and Neck Squamous Carcinoma Cells and Tumors. PMID:28838998
Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas. PMID:28836293
Expression of neurotensin receptor 1 in endometrial adenocarcinoma is correlated with histological grade and clinical outcome. PMID:28836043
The scaffold protein Ajuba suppresses CdGAP activity in epithelia to maintain stable cell-cell contacts. PMID:28835688
SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis. PMID:28827661
Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. PMID:28827401
Identification of NRAS isoform 2 overexpression as a mechanism facilitating BRAF inhibitor resistance in malignant melanoma. PMID:28827320
Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making. PMID:28825054
Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. PMID:28820959
Single-Color Digital PCR Provides High-Performance Detection of Cancer Mutations from Circulating DNA. PMID:28818432
"UPRegulation" of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses. PMID:28815041
Modeling of RAS complexes supports roles in cancer for less studied partners. PMID:28815022
iCAVE: an open source tool for visualizing biomolecular networks in 3D, stereoscopic 3D and immersive 3D. PMID:28814063
An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis. PMID:28813674
CDK4/6 inhibition triggers anti-tumour immunity. PMID:28813415
LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer. PMID:28811844
ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. PMID:28808226
Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence. PMID:28807943
Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors. PMID:28807940
Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish. PMID:28806732
A systems approach reveals distinct metabolic strategies among the NCI-60 cancer cell lines. PMID:28806730
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. PMID:28805820
AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma. PMID:28805815
Lumican delays melanoma growth in mice and drives tumor molecular assembly as well as response to matrix-targeted TAX2 therapeutic peptide. PMID:28794454
Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance. PMID:28794284
Metalloprotease-dependent activation of EGFR modulates CD44+/CD24- populations in triple negative breast cancer cells through the MEK/ERK pathway. PMID:28791489
Expression of CD70 (CD27L) Is Associated With Epithelioid and Sarcomatous Features in IDH-Wild-Type Glioblastoma. PMID:28789475
PIK3R1Met326Ile germline mutation correlates with cysteine-rich protein 61 expression and poor prognosis in glioblastoma. PMID:28785028
Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma. PMID:28784174
Identification of essential genes for cancer immunotherapy. PMID:28783722
The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma. PMID:28783171
Amplification of the NSD3-BRD4-CHD8 pathway in pelvic high-grade serous carcinomas of tubo-ovarian and endometrial origin. PMID:28781807
Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes. PMID:28771473
Endothelial protein C receptor is overexpressed in colorectal cancer as a result of amplification and hypomethylation of chromosome 20q. PMID:28770100
Molecular Characterization of Somatic Alterations in Dukes' B and C Colorectal Cancers by Targeted Sequencing. PMID:28769798
Sexual dimorphism in glioma glycolysis underlies sex differences in survival. PMID:28768910
Deleterious Effect of RAS and Evolutionary High-risk TP53 Double Mutation in Colorectal Liver Metastases. PMID:28767562
Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines. PMID:28767070
FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion. PMID:28767039
Targeting latency-associated peptide promotes antitumor immunity. PMID:28763794
UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept. PMID:28763470
Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma. PMID:28759042
TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis. PMID:28759040
High-depth, high-accuracy microsatellite genotyping enables precision lung cancer risk classification. PMID:28759038
Cell genomics and immunosuppressive biomarker expression influence PD-L1 immunotherapy treatment responses in HNSCC-a computational study. PMID:28756882
Vaccines targeting helper T cells for cancer immunotherapy. PMID:28755541
The Landscape of Whole-genome Alterations and Pathologic Features in Genitourinary Malignancies: An Analysis of the Cancer Genome Atlas. PMID:28753846
Krüppel-like factor 4 acts as a potential therapeutic target of Sijunzi decoction for treatment of colorectal cancer. PMID:28752861
Exome sequencing identifies recurrent BCOR alterations and the absence of KLF2, TNFAIP3 and MYD88 mutations in splenic diffuse red pulp small B-cell lymphoma. PMID:28751561
Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer. PMID:28751448
Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies. PMID:28750640
Mutations targeting the coagulation pathway are enriched in brain metastases. PMID:28747664
AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination. PMID:28747635
Regulation of spindle and kinetochore-associated protein 1 by antitumor miR-10a-5p in renal cell carcinoma. PMID:28746769
PSMA-Targeted Theranostic Nanocarrier for Prostate Cancer. PMID:28744329
Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas. PMID:28742845
Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia. PMID:28742792
Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor. PMID:28741798
Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. PMID:28735896
UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses. PMID:28732212
Renal cell tumors with clear cell histology and intact VHL and chromosome 3p: a histological review of tumors from the Cancer Genome Atlas database. PMID:28731045
Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene. PMID:28731043
Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer. PMID:28724614
Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer. PMID:28717230
Clinical Significance and Effect of lncRNA HOXA11-AS in NSCLC: A Study Based on Bioinformatics, In Vitro and in Vivo Verification. PMID:28717185
Association Of Plasma And Urinary Mutant DNA With Clinical Outcomes In Muscle Invasive Bladder Cancer. PMID:28717136
IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model. PMID:28714957
Combined deletion and DNA methylation result in silencing of FAM107A gene in laryngeal tumors. PMID:28710449
Emerging Roles for SIRT5 in Metabolism and Cancer. PMID:28707979
Clinical value of integrated-signature miRNAs in esophageal cancer. PMID:28707457
Detection of early pancreatic ductal adenocarcinoma with thrombospondin-2 and CA19-9 blood markers. PMID:28701476
Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets. PMID:28699633
Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing. PMID:28692054
Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts. PMID:28691904
RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis. PMID:28689994
De-escalation of treatment in HER2-positive breast cancer: Determinants of response and mechanisms of resistance. PMID:28687441
Copy number alteration of neuropeptides and receptors in multiple cancers. PMID:28676692
Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF. PMID:28676500
Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer. PMID:28675450
The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers. PMID:28674494
Mechanical cue-induced YAP instructs Skp2-dependent cell cycle exit and oncogenic signaling. PMID:28673931
Variation of mutant allele frequency in NRAS Q61 mutated melanomas. PMID:28668077
SATB2 suppresses non-small cell lung cancer invasiveness by G9a. PMID:28667416
Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition. PMID:28659312
Stroma-derived Fibrinogen-like Protein 2 Activates Cancer-associated Fibroblasts to Promote Tumor Growth in Lung Cancer. PMID:28656005
PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma. PMID:28654422
Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma. PMID:28650484
Genotranscriptomic meta-analysis of the CHD family chromatin remodelers in human cancers - initial evidence of an oncogenic role for CHD7. PMID:28649742
Application of open-access databases to determine functional connectivity between resveratrol-binding protein QR2 and colorectal carcinoma. PMID:28646291
Base Excision Repair Variants in Cancer. PMID:28645367
Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer. PMID:28641312
Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression. PMID:28639619
The NF1 somatic mutational landscape in sporadic human cancers. PMID:28637487
Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cells. PMID:28635133
Molecular regulation and pharmacological targeting of the β-catenin destruction complex. PMID:28634996
How Schwann cells facilitate cancer progression in nerves. PMID:28631007
OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. PMID:28628118
Genome-wide methylome and chromatin interactome identify abnormal enhancer to be risk factor of breast cancer. PMID:28621677
Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival. PMID:28621318
Structural insights into the function of ZRANB3 in replication stress response. PMID:28621305
Epigenome-wide association study of chronic obstructive pulmonary disease and lung function in Koreans. PMID:28621160
Genomic landscape and evolution of metastatic chromophobe renal cell carcinoma. PMID:28614790
Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma. PMID:28614736
Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death. PMID:28613975
Regulation of ITGA3 by the anti-tumor miR-199 family inhibits cancer cell migration and invasion in head and neck cancer. PMID:28612520
RIN1 promotes renal cell carcinoma malignancy by activating EGFR signaling through Rab25. PMID:28612496
Tumor diversity and evolution revealed through RADseq. PMID:28611298
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. PMID:28611215
FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC. PMID:28607447
Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT. PMID:28604746
p90RSK Blockade Inhibits Dual BRAF and MEK Inhibitor-Resistant Melanoma by Targeting Protein Synthesis. PMID:28599981
Cholesterol uptake and regulation in high-grade and lethal prostate cancers. PMID:28595267
MYC Deregulation in Primary Human Cancers. PMID:28587062
Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay. PMID:28586478
Reduced Smad4 expression and DNA topoisomerase inhibitor chemosensitivity in non-small cell lung cancer. PMID:28577946
Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53. PMID:28574838
AACR Project GENIE: Powering Precision Medicine through an International Consortium. PMID:28572459
JUN-Mediated Downregulation of EGFR Signaling Is Associated with Resistance to Gefitinib in EGFR-mutant NSCLC Cell Lines. PMID:28566434
Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers. PMID:28566428
Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit. PMID:28564602
EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe? PMID:28561778
Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions. PMID:28561041
HDAC2 overexpression correlates with aggressive clinicopathological features and DNA-damage response pathway of breast cancer. PMID:28560068
FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells. PMID:28558758
Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice. PMID:28553932
Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines. PMID:28545079
Functional interaction between co-expressed MAGE-A proteins. PMID:28542476
Ezh2 Acts as a Tumor Suppressor in Kras-driven Lung Adenocarcinoma. PMID:28539837
The potential of organoids in urological cancer research. PMID:28534535
PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models. PMID:28532501
A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo. PMID:28530655
Induction of senescence in primary glioblastoma cells by serum and TGFβ. PMID:28526854
XLF-mediated NHEJ activity in hepatocellular carcinoma therapy resistance. PMID:28526069
ZNF281 Promotes Growth and Invasion of Pancreatic Cancer Cells by Activating Wnt/β-Catenin Signaling. PMID:28523575
Analyses of publicly available genomics resources define FGF-2-expressing bladder carcinomas as EMT-prone, proliferative tumors with low mutation rates and high expression of CTLA-4, PD-1 and PD-L1. PMID:28515962
Nicotinamide metabolism regulates glioblastoma stem cell maintenance. PMID:28515364
Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer. PMID:28512244
Focus on cutaneous and uveal melanoma specificities. PMID:28512236
Long Non-Coding RNA SNHG6 as a Potential Biomarker for Hepatocellular Carcinoma. PMID:28508329
Pro-necrotic molecules impact local immunosurveillance in human breast cancer. PMID:28507808
Formyl peptide receptor 1 suppresses gastric cancer angiogenesis and growth by exploiting inflammation resolution pathways. PMID:28507800
A Subset of Malignant Mesotheliomas in Young Adults Are Associated With Recurrent EWSR1/FUS-ATF1 Fusions. PMID:28505004
Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity. PMID:28504970
Fibulin-3 promotes muscle-invasive bladder cancer. PMID:28504717
Cytoplasmic translocation of MTA1 coregulator promotes de-repression of SGK1 transcription in hypoxic cancer cells. PMID:28504714
Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer. PMID:28504713
Expression and alternative splicing of the cyclin-dependent kinase inhibitor-3 gene in human cancer. PMID:28504190
Analysis of genomic variation in lung adenocarcinoma patients revealed the critical role of PI3K complex. PMID:28503373
Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR. PMID:28499833
A novel microRNA regulator of prostate cancer epithelial-mesenchymal transition. PMID:28498363
RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma. PMID:28497782
Next-Generation Sequencing-based genomic profiling of brain metastases of primary ovarian cancer identifies high number of BRCA-mutations. PMID:28497333
AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer. PMID:28494797
Progression inference for somatic mutations in cancer. PMID:28492066
Identification of potential biomarkers and analysis of prognostic values in head and neck squamous cell carcinoma by bioinformatics analysis. PMID:28490889
Recurrent promoter mutations in melanoma are defined by an extended context-specific mutational signature. PMID:28489852
HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer. PMID:28487443
Genetic landscape of clear cell endometrial cancer and the era of precision medicine. PMID:28485840
TWIST1-WDR5-Hottip Regulates Hoxa9 Chromatin to Facilitate Prostate Cancer Metastasis. PMID:28484075
The zinc-finger transcriptional factor Slug transcriptionally downregulates ERα by recruiting lysine-specific demethylase 1 in human breast cancer. PMID:28481366
Characterization of potential driver mutations involved in human breast cancer by computational approaches. PMID:28477017
Protein kinase C as a tumor suppressor. PMID:28476658
Association of body mass index with ER, PR and 14-3-3σ expression in tumor and stroma of type I and type II endometrial carcinoma. PMID:28476021
Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer. PMID:28473532
Clinical value of R-spondins in triple-negative and metaplastic breast cancers. PMID:28472820
Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma. PMID:28472509
MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets. PMID:28472340
Transcriptomic immunologic signature associated with favorable clinical outcome in basal-like breast tumors. PMID:28472085
In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma. PMID:28467784
HER2-positive breast cancer cells expressing elevated FAM83A are sensitive to FAM83A loss. PMID:28463969
Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition. PMID:28462496
Sirtuin 2 mutations in human cancers impair its function in genome maintenance. PMID:28461331
Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling. PMID:28460443
Oncogenic KRAS-associated gene signature defines co-targeting of CDK4/6 and MEK as a viable therapeutic strategy in colorectal cancer. PMID:28459468
Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells. PMID:28459464
Impaired AMPK Activity Drives Age-Associated Acute Lung Injury after Hemorrhage. PMID:28459384
A PanorOmic view of personal cancer genomes. PMID:28453651
Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate. PMID:28452363
Epigenetic dysregulation of ID4 predicts disease progression and treatment outcome in myeloid malignancies. PMID:28452111
Writing, erasing and reading histone lysine methylations. PMID:28450737
Perturbation of DROSHA and DICER expression by human papillomavirus 16 oncoproteins. PMID:28448850
Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma. PMID:28441149
WIP1 phosphatase as pharmacological target in cancer therapy. PMID:28439615
A murine preclinical syngeneic transplantation model for breast cancer precision medicine. PMID:28439535
Lkb1 deletion in murine B lymphocytes promotes cell death and cancer. PMID:28435024
A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks. PMID:28432356
SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway. PMID:28429243
Limitations of Personalized Medicine and Gene Assays for Breast Cancer. PMID:28428927
High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors. PMID:28426873
Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples. PMID:28426665
Integrative epigenetic and genetic pan-cancer somatic alteration portraits. PMID:28426276
Systematic analysis of gene expression alterations and clinical outcomes of adenylate cyclase-associated protein in cancer. PMID:28423713
Mitotic read-out genes confer poor outcome in luminal A breast cancer tumors. PMID:28423514
The transcriptional STAT3 is a potential target, whereas transcriptional STAT5A/5B/6 are new biomarkers for prognosis in human breast carcinoma. PMID:28422733
Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication. PMID:28416140
Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-miR-150 as antitumor miRNAs. PMID:28415821
Identification of long non-coding RNAs that stimulate cell survival in bladder cancer. PMID:28415801
Detection of COPB2 as a KRAS synthetic lethal partner through integration of functional genomics screens. PMID:28415695
The combined effect of USP7 inhibitors and PARP inhibitors in hormone-sensitive and castration-resistant prostate cancer cells. PMID:28415632
The role of GLI1 for 5-Fu resistance in colorectal cancer. PMID:28413604
Whole-Genome Sequence of the Metastatic PC3 and LNCaP Human Prostate Cancer Cell Lines. PMID:28413162
Development of a novel prognostic signature of long non-coding RNAs in lung adenocarcinoma. PMID:28409273
ETS (E26 transformation-specific) up-regulation of the transcriptional co-activator TAZ promotes cell migration and metastasis in prostate cancer. PMID:28408625
The immune molecular landscape of the B7 and TNFR immunoregulatory ligand-receptor families in head and neck cancer: A comprehensive overview and the immunotherapeutic implications. PMID:28405520
NUSAP1 promotes invasion and metastasis of prostate cancer. PMID:28404898
Therapeutic Response of Metastatic Colorectal Cancer Harboring a KRAS Missense Mutation After Combination Chemotherapy With the EGFR Inhibitor Panitumumab. PMID:28404754
IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing. PMID:28403884
IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis. PMID:28399871
Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer. PMID:28397780
Metastasis-associated protein 1 is an upstream regulator of DNMT3a and stimulator of insulin-growth factor binding protein-3 in breast cancer. PMID:28393842
Identification of IGF-1-enhanced cytokine expressions targeted by miR-181d in glioblastomas via an integrative miRNA/mRNA regulatory network analysis. PMID:28389653
The tumor suppressor interferon regulatory factor 8 inhibits β-catenin signaling in breast cancers, but is frequently silenced by promoter methylation. PMID:28388578
Novel miRNA-mRNA interactions conserved in essential cancer pathways. PMID:28387377
Multinuclear NMR and MRI Reveal an Early Metabolic Response to mTOR Inhibition in Sarcoma. PMID:28386017
Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade. PMID:28382931
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer. PMID:28382170
Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. PMID:28381423
CD47 promotes ovarian cancer progression by inhibiting macrophage phagocytosis. PMID:28380460
Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival. PMID:28380429
The Evolving Role of the Estrogen Receptor Mutations in Endocrine Therapy-Resistant Breast Cancer. PMID:28374222
The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway. PMID:28372542
Sox2 is dispensable for primary melanoma and metastasis formation. PMID:28368416
HBEGF promotes gliomagenesis in the context of Ink4a/Arf and Pten loss. PMID:28368403
Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer. PMID:28368395
Jmjd6, a JmjC Dioxygenase with Many Interaction Partners and Pleiotropic Functions. PMID:28360925
Safety and utility of image-guided research biopsies in relapsed high-grade serous ovarian carcinoma-experience of the BriTROC consortium. PMID:28359078
Differential molecular regulation of processing and membrane expression of Type-I BMP receptors: implications for signaling. PMID:28357470
Diagnostic and prognostic roles of IRAK1 in hepatocellular carcinoma tissues: an analysis of immunohistochemistry and RNA-sequencing data from the cancer genome atlas. PMID:28356759
Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing. PMID:28350094
SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer. PMID:28346421
Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer. PMID:28344890
CpG island methylator phenotype in adenocarcinomas from the digestive tract: Methods, conclusions, and controversies. PMID:28344746
PI3K signaling in cancer: beyond AKT. PMID:28343126
Lipid quantification by Raman microspectroscopy as a potential biomarker in prostate cancer. PMID:28342983
Leveraging molecular datasets for biomarker-based clinical trial design in glioblastoma. PMID:28339723
Next-generation sequencing of urine specimens: A novel platform for genomic analysis in patients with non-muscle-invasive urothelial carcinoma treated with bacille Calmette-Guérin. PMID:28339163
Integrative analysis of multi-omics data reveals distinct impacts of DDB1-CUL4 associated factors in human lung adenocarcinomas. PMID:28336923
NELF-E is recruited to DNA double-strand break sites to promote transcriptional repression and repair. PMID:28336775
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies. PMID:28336552
PathwayMapper: a collaborative visual web editor for cancer pathways and genomic data. PMID:28334343
PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4. PMID:28332630
Regulation of ITGA3 by the dual-stranded microRNA-199 family as a potential prognostic marker in bladder cancer. PMID:28324890
Effect of method of deduplication on estimation of differential gene expression using RNA-seq. PMID:28321364
The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia. PMID:28321123
FOXA1 inhibits prostate cancer neuroendocrine differentiation. PMID:28319070
Towards precision oncology in RET-aberrant cancers. PMID:28318386
Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation. PMID:28317937
Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry. PMID:28302160
NCAPH plays important roles in human colon cancer. PMID:28300828
Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma. PMID:28296713
Inhibitors of STAT3, β-catenin, and IGF-1R sensitize mouse PIK3CA-mutant breast cancer to PI3K inhibitors. PMID:28296140
TRAF3/CYLD mutations identify a distinct subset of human papillomavirus-associated head and neck squamous cell carcinoma. PMID:28295222
Comprehensive discovery of subsample gene expression components by information explanation: therapeutic implications in cancer. PMID:28292312
Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer. PMID:28290516
Targeting Lyn regulates Snail family shuttling and inhibits metastasis. PMID:28288135
AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins. PMID:28287129
Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor. PMID:28283201
BRAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumorigenesis. PMID:28281325
Marked for death: targeting epigenetic changes in cancer. PMID:28280262
Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells. PMID:28278050
B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers. PMID:28276478
SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer. PMID:28273073
Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer. PMID:28267766
Precision medicine driven by cancer systems biology. PMID:28265786
Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells. PMID:28264911
Piccolo mediates EGFR signaling and acts as a prognostic biomarker in esophageal squamous cell carcinoma. PMID:28263981
Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer. PMID:28263970
HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors. PMID:28255362
Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity. PMID:28255353
Using cancer genomics to guide clinical decisions. PMID:28253425
Key Roles of AXL and MER Receptor Tyrosine Kinases in Resistance to Multiple Anticancer Therapies. PMID:28251492
Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. PMID:28249155
ZEB1 regulates glioma stemness through LIF repression. PMID:28246407
TET2 in Normal and Malignant Hematopoiesis. PMID:28242787
Androgen Receptor Signaling in Bladder Cancer. PMID:28241422
PIK3CA-mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation. PMID:28233937
Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17. PMID:28232483
Mining Cancer Transcriptomes: Bioinformatic Tools and the Remaining Challenges. PMID:28229366
Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma. PMID:28228279
Mcm10: A Dynamic Scaffold at Eukaryotic Replication Forks. PMID:28218679
Amphiregulin as a Novel Serum Marker of Puberty in Girls. PMID:28216130
Role of a p53 polymorphism in the development of nonfunctional pituitary adenomas. PMID:28214592
High PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 function. PMID:28213783
Emerging themes of regulation at the Golgi. PMID:28213314
Genetic characterization of Polish ccRCC patients: somatic mutation analysis of PBRM1, BAP1 and KDMC5, genomic SNP array analysis in tumor biopsy and preliminary results of chromosome aberrations analysis in plasma cell free DNA. PMID:28212566
The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. PMID:28211885
OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. PMID:28209616
ID2 promotes survival of glioblastoma cells during metabolic stress by regulating mitochondrial function. PMID:28206987
PI3K pathway mutations are associated with longer time to local progression after radioembolization of colorectal liver metastases. PMID:28206962
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies. PMID:28205554
Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. PMID:28202506
Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas. PMID:28201779
MiR-143 Targeting TAK1 Attenuates Pancreatic Ductal Adenocarcinoma Progression via MAPK and NF-κB Pathway In Vitro. PMID:28194669
Real-time genomic profiling of histiocytoses identifies early-kinase domain BRAF alterations while improving treatment outcomes. PMID:28194436
Circulating and tissue biomarkers in early-stage non-small cell lung cancer. PMID:28194229
Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis. PMID:28191885
Bladder cancer cell growth and motility implicate cannabinoid 2 receptor-mediated modifications of sphingolipids metabolism. PMID:28191815
A potential panel of four-long noncoding RNA signature in prostate cancer predicts biochemical recurrence-free survival and disease-free survival. PMID:28188414
Upregulation of FAM84B during prostate cancer progression. PMID:28186973
Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and PIK3CA Mutations. PMID:28184015
ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib. PMID:28182994
KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1. PMID:28180290
Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. PMID:28177281
LncRNA AK023948 is a positive regulator of AKT. PMID:28176758
An Integrated Approach Identifies Mediators of Local Recurrence in Head and Neck Squamous Carcinoma. PMID:28174235
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. PMID:28174173
A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer. PMID:28169991
Physical and Functional Interactions between ELL2 and RB in the Suppression of Prostate Cancer Cell Proliferation, Migration, and Invasion. PMID:28167296
Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling. PMID:28163016
SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation. PMID:28159833
Clinical significance and effect of AEG-1 on the proliferation, invasion, and migration of NSCLC: a study based on immunohistochemistry, TCGA, bioinformatics, in vitro and in vivo verification. PMID:28152520
microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis through revival of TWIST1 in renal cell carcinoma. PMID:28152509
Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer. PMID:28148288
Keratin 5 overexpression is associated with serous ovarian cancer recurrence and chemotherapy resistance. PMID:28147318
MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy. PMID:28146422
KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. PMID:28145866
Master Regulators of Oncogenic KRAS Response in Pancreatic Cancer: An Integrative Network Biology Analysis. PMID:28141826
The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation. PMID:28137908
E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling. PMID:28137882
The Cdc42/Rac1 regulator CdGAP is a novel E-cadherin transcriptional co-repressor with Zeb2 in breast cancer. PMID:28135249
Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice. PMID:28134936
Gene Signature Associated with Upregulation of the Wnt/β-Catenin Signaling Pathway Predicts Tumor Response to Transarterial Embolization. PMID:28126478
Clinical and Morphologic Features of ETV6-NTRK3 Translocated Papillary Thyroid Carcinoma in an Adult Population Without Radiation Exposure. PMID:28125451
CXCR4-CXCL12-CXCR7, TLR2-TLR4, and PD-1/PD-L1 in colorectal cancer liver metastases from neoadjuvant-treated patients. PMID:28123896
Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk. PMID:28123876
Genome-wide DNA copy number analysis in clonally expanded human ovarian cancer cells with distinct invasive/migratory capacities. PMID:28122348
Genome-wide screen identifies a novel prognostic signature for breast cancer survival. PMID:28122328
Combined evaluation of the FAS cell surface death receptor and CD8+ tumor infiltrating lymphocytes as a prognostic biomarker in breast cancer. PMID:28121628
Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity. PMID:28117753
Molecular characterization of CD44+/CD24-/Ck+/CD45- cells in benign and malignant breast lesions. PMID:28116522
3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets. PMID:28115009
Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL. PMID:28114281
The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma. PMID:28114277
Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer. PMID:28112739
Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma. PMID:28108737
Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1. PMID:28108589
Quantitative Proteomic Profiling of Tachyplesin I Targets in U251 Gliomaspheres. PMID:28106765
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA. PMID:28106072
Ubiquitin specific protease 21 upregulation in breast cancer promotes cell tumorigenic capability and is associated with the NOD-like receptor signaling pathway. PMID:28105162
WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer. PMID:28102297
Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. PMID:28101337
Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma. PMID:28099935
The EMSY threonine 207 phospho-site is required for EMSYdriven suppression of DNA damage repair. PMID:28099152
Metastasis regulation by PPARD expression in cancer cells. PMID:28097239
β-Catenin haploinsufficiency promotes mammary tumorigenesis in an ErbB2-positive basal breast cancer model. PMID:28096336
The role of MDM2 and MDM4 in breast cancer development and prevention. PMID:28096293
The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma. PMID:28096290
Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma. PMID:28096186
Iron overload and altered iron metabolism in ovarian cancer. PMID:28095368
Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival. PMID:28094268
SPAG6 and L1TD1 are transcriptionally regulated by DNA methylation in non-small cell lung cancers. PMID:28093071
Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality. PMID:28092670
Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase. PMID:28090586
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma. PMID:28082722
TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation. PMID:28082682
FAM83 family oncogenes are broadly involved in human cancers: an integrative multi-omics approach. PMID:28078827
Translation from unconventional 5' start sites drives tumour initiation. PMID:28077873
HDAC10 as a potential therapeutic target in ovarian cancer. PMID:28073598
Expression site of P2RY12 in residential microglial cells in astrocytomas correlates with M1 and M2 marker expression and tumor grade. PMID:28073370
APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. PMID:28069571
SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. PMID:28067909
Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular Carcinoma. PMID:28067792
KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors. PMID:28067315
Computational polypharmacology: a new paradigm for drug discovery. PMID:28067061
Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients. PMID:28061480
Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate. PMID:28059163
Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions. PMID:28057438
Integrative genomic and transcriptomic analysis for pinpointing recurrent alterations of plant homeodomain genes and their clinical significance in breast cancer. PMID:28055972
Genomic analysis of exceptional responders to radiotherapy reveals somatic mutations in ATM. PMID:28055970
Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer. PMID:28055301
Expression of T-Lymphocyte Markers in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer. PMID:28053626
PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion. PMID:28051998
The Role of Aneuploidy in Cancer Evolution. PMID:28049655
Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival. PMID:28039471
Key Survival Factor, Mcl-1, Correlates with Sensitivity to Combined Bcl-2/Bcl-xL Blockade. PMID:28039357
The role of prostate tumor overexpressed 1 in cancer progression. PMID:28029646
Defining the boundaries and expanding the utility of head and neck cancer patient derived xenografts. PMID:28024726
Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53. PMID:28008906
Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations. PMID:28007021
The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism. PMID:28003335
The Heat Shock Transcription Factor HSF1 Induces Ovarian Cancer Epithelial-Mesenchymal Transition in a 3D Spheroid Growth Model. PMID:27997575
Nucleophosmin Mutations Induce Chemosensitivity in THP-1 Leukemia Cells by Suppressing NF-κB Activity and Regulating Bax/Bcl-2 Expression. PMID:27994664
A novel NFIA-NFκB feed-forward loop contributes to glioblastoma cell survival. PMID:27994064
Flexible model-based clustering of mixed binary and continuous data: application to genetic regulation and cancer. PMID:27994031
Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists. PMID:27993330
Circulating cell-free DNA-based epigenetic assay can detect early breast cancer. PMID:27993161
A CRISPR/Cas9 Functional Screen Identifies Rare Tumor Suppressors. PMID:27982060
Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology-molecular associations: clinical and biological implications. PMID:27982025
Comprehensive analysis of the long noncoding RNA HOXA11-AS gene interaction regulatory network in NSCLC cells. PMID:27980454
Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase. PMID:27979310
Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression. PMID:27977328
Targeting metastasis-initiating cells through the fatty acid receptor CD36. PMID:27974793
Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers. PMID:27974415
ERK-mediated NF-κB activation through ASIC1 in response to acidosis. PMID:27941930
The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination. PMID:27941881
NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors? PMID:27938406
Large-Scale Analysis of Gene Expression Data Reveals a Novel Gene Expression Signature Associated with Colorectal Cancer Distant Recurrence. PMID:27935967
CASP9 germline mutation in a family with multiple brain tumors. PMID:27935156
Profiling lung adenocarcinoma by liquid biopsy: can one size fit all? PMID:27933110
MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib. PMID:27931239
Concordance between somatic copy number loss and down-regulated expression: A pan-cancer study of cancer predisposition genes. PMID:27929028
Gene expression and pathway analysis of CTNNB1 in cancer and stem cells. PMID:27928465
AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex. PMID:27927748
Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin. PMID:27926874
Higher programmed cell death 1 ligand 1 (PD-L1) mRNA level in clear cell renal cell carcinomas is associated with a favorable outcome due to the active immune responses in tumor tissues. PMID:27926518
ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin. PMID:27923832
Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases. PMID:27923045
Maximising the potential of AKT inhibitors as anti-cancer treatments. PMID:27919797
Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy. PMID:27918595
GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer. PMID:27918237
Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer. PMID:27916600
IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity. PMID:27913435
Y-box binding protein-1 promotes hepatocellular carcinoma-initiating cell progression and tumorigenesis via Wnt/β-catenin pathway. PMID:27911878
L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling. PMID:27910855
The implication of FLT3 amplification for FLT targeted therapeutics in solid tumors. PMID:27906677
Tumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour. PMID:27906134
LncRNAs are altered in lung squamous cell carcinoma and lung adenocarcinoma. PMID:27903974
Association of a cytarabine chemosensitivity related gene expression signature with survival in cytogenetically normal acute myeloid leukemia. PMID:27903973
MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma. PMID:27903915
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations. PMID:27903500
Intrinsic HER2 V777L mutation mediates resistance to trastuzumab in a breast cancer patient. PMID:27900589
Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification. PMID:27900363
Aberrations in the Iron Regulatory Gene Signature Are Associated with Decreased Survival in Diffuse Infiltrating Gliomas. PMID:27898674
Functional exploration of colorectal cancer genomes using Drosophila. PMID:27897178
MUC1-C activates BMI1 in human cancer cells. PMID:27893710
MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer. PMID:27893706
TFAP2C-mediated upregulation of TGFBR1 promotes lung tumorigenesis and epithelial-mesenchymal transition. PMID:27885255
Rs3842530 Polymorphism in MicroRNA-205 Host Gene in Lung and Breast Cancer Patients. PMID:27885248
Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis. PMID:27884605
Patterns of ribosomal protein expression specify normal and malignant human cells. PMID:27884178
Institutional implementation of clinical tumor profiling on an unselected cancer population. PMID:27882345
Deletion of 8p is an independent prognostic parameter in prostate cancer. PMID:27880722
Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors. PMID:27875628
Clinical and genetic determinants of ovarian metastases from colorectal cancer. PMID:27875625
Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. PMID:27870829
The Importance of Biopsy in the Era of Molecular Medicine. PMID:27870685
Quantitative secretomic analysis of pancreatic cancer cells in serum-containing conditioned medium. PMID:27869176
A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease. PMID:27863505
Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin. PMID:27863405
Molecular characterization reveals NF1 deletions and FGFR1-activating mutations in a pediatric spinal oligodendroglioma. PMID:27862886
The challenges of tumor genetic diversity. PMID:27861749
Deletion of 18q is a strong and independent prognostic feature in prostate cancer. PMID:27861151
Head and neck squamous cell carcinoma: Ambiguous human papillomavirus status, elevated p16, and deleted retinoblastoma 1. PMID:27859938
High-throughput sequencing of two populations of extracellular vesicles provides an mRNA signature that can be detected in the circulation of breast cancer patients. PMID:27858503
GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis. PMID:27856536
Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures. PMID:27855702
SNAP23 promotes the malignant process of ovarian cancer. PMID:27855700
IGFBP2 expression predicts IDH-mutant glioma patient survival. PMID:27852048
Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression. PMID:27849608
IAP antagonists induce anti-tumor immunity in multiple myeloma. PMID:27841872
Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma. PMID:27837031
Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors. PMID:27837027
Combination of COX-2 expression and PIK3CA mutation as prognostic and predictive markers for celecoxib treatment in breast cancer. PMID:27835884
ZHX1 Promotes the Proliferation, Migration and Invasion of Cholangiocarcinoma Cells. PMID:27835650
p16 overexpression and 9p21 deletion are linked to unfavorable tumor phenotype in breast cancer. PMID:27835607
Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells. PMID:27835572
Long intergenic non-coding RNA 271 is predictive of a poorer prognosis of papillary thyroid cancer. PMID:27833134
Adhesion GPCRs in Tumorigenesis. PMID:27832497
SUMOylated MAFB promotes colorectal cancer tumorigenesis. PMID:27829226
Amplification of MUC1 in prostate cancer metastasis and CRPC development. PMID:27825118
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer. PMID:27824159
TET2 binds the androgen receptor and loss is associated with prostate cancer. PMID:27819678
Protease-activated receptor-1 inhibits proliferation but enhances leukemia stem cell activity in acute myeloid leukemia. PMID:27819671
The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. PMID:27819275
p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. PMID:27815262
A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. PMID:27799065
Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours. PMID:27798604
Phosphatidylinositol 4-kinase IIβ negatively regulates invadopodia formation and suppresses an invasive cellular phenotype. PMID:27798239
Serpin E2 promotes breast cancer metastasis by remodeling the tumor matrix and polarizing tumor associated macrophages. PMID:27793045
FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer. PMID:27791031
TCGA Expedition: A Data Acquisition and Management System for TCGA Data. PMID:27788220
A Systems Biology Comparison of Ovarian Cancers Implicates Putative Somatic Driver Mutations through Protein-Protein Interaction Models. PMID:27788148
PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. PMID:27775705
G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion. PMID:27765922
Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants. PMID:27760319
Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations. PMID:27758891
Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation. PMID:27758883
Genomic Biomarkers of a Randomized Trial Comparing First-line Everolimus and Sunitinib in Patients with Metastatic Renal Cell Carcinoma. PMID:27751729
PlexinD1 Is a Novel Transcriptional Target and Effector of Notch Signaling in Cancer Cells. PMID:27749937
Using Pharmacogenomic Databases for Discovering Patient-Target Genes and Small Molecule Candidates to Cancer Therapy. PMID:27746730
Comprehensive Genetic Landscape of Uveal Melanoma by Whole-Genome Sequencing. PMID:27745836
Cohesin Mutations in Cancer. PMID:27742736
MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer. PMID:27731867
Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model. PMID:27729860
Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients. PMID:27729614
Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3. PMID:27729585
Increased global transcription activity as a mechanism of replication stress in cancer. PMID:27725641
Upregulation of HSF1 in estrogen receptor positive breast cancer. PMID:27713164
Clinical Relevance and Molecular Phenotypes in Gastric Cancer, of TP53 Mutations and Gene Expressions, in Combination With Other Gene Mutations. PMID:27708434
APSA Awardee Submission: Tumor/cancer stem cell marker doublecortin-like kinase 1 in liver diseases. PMID:27694285
Predicting PD-L1 expression on human cancer cells using next-generation sequencing information in computational simulation models. PMID:27688163
Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells. PMID:27684953
Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix. PMID:27683114
Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells. PMID:27681615
The possible roles of B-cell novel protein-1 (BCNP1) in cellular signalling pathways and in cancer. PMID:27680505
Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design. PMID:27672311
OSAnalyzer: A Bioinformatics Tool for the Analysis of Gene Polymorphisms Enriched with Clinical Outcomes. PMID:27669316
Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition. PMID:27663592
SEPT9 and SHOX2 DNA methylation status and its utility in the diagnosis of colonic adenomas and colorectal adenocarcinomas. PMID:27660666
Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer. PMID:27655714
Molecular Pap smear: HPV genotype and DNA methylation of ADCY8, CDH8, and ZNF582 as an integrated biomarker for high-grade cervical cytology. PMID:27651839
CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network. PMID:27650546
SHP2 phosphatase as a novel therapeutic target for melanoma treatment. PMID:27650545
ZNF703 Overexpression may act as an oncogene in non-small cell lung cancer. PMID:27650486
Individual and Combined Expression of DNA Damage Response Molecules PARP1, γH2AX, BRCA1, and BRCA2 Predict Shorter Survival of Soft Tissue Sarcoma Patients. PMID:27643881
Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. PMID:27642788
Multi-omics approach to infer cancer therapeutic targets on chromosome 20q across tumor types. PMID:27642640
ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA. PMID:27641332
Beta-adrenergic signaling promotes tumor angiogenesis and prostate cancer progression through HDAC2-mediated suppression of thrombospondin-1. PMID:27641328
Alkylating Agent-Induced NRF2 Blocks Endoplasmic Reticulum Stress-Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis. PMID:27638861
Histone H3 lysine 23 acetylation is associated with oncogene TRIM24 expression and a poor prognosis in breast cancer. PMID:27638829
MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer. PMID:27638352
A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice. PMID:27634876
Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin. PMID:27633757
Study of apoptosis-related interactions in colorectal cancer. PMID:27629291
Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer. PMID:27622076
Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate. PMID:27621311
Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype. PMID:27617860
Ecotropic viral integration site 1, a novel oncogene in prostate cancer. PMID:27617580
Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates epidermal growth factor receptor in prostate cancer. PMID:27611943
Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors. PMID:27611922
Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis. PMID:27610619
Pro-invasive Effect of Proto-oncogene PBF Is Modulated by an Interaction with Cortactin. PMID:27603901
Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer. PMID:27602502
Association of FGD1 polymorphisms with early-onset breast cancer. PMID:27602141
Cytidine Deaminase Deficiency Reveals New Therapeutic Opportunities against Cancer. PMID:27601591
miR-564 acts as a dual inhibitor of PI3K and MAPK signaling networks and inhibits proliferation and invasion in breast cancer. PMID:27600857
Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer. PMID:27599661
Mutational load and mutational patterns in relation to age in head and neck cancer. PMID:27596625
ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors. PMID:27596438
Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. PMID:27590350
Dysregulation of TGFβ1 Activity in Cancer and Its Influence on the Quality of Anti-Tumor Immunity. PMID:27589814
Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity. PMID:27588951
Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma. PMID:27586084
Exploring and visualizing multidimensional data in translational research platforms. PMID:27585944
Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase. PMID:27585847
Will targeting PI3K/Akt/mTOR signaling work in hematopoietic malignancies? PMID:27583254
Minireview: The Link Between ERα Corepressors and Histone Deacetylases in Tamoxifen Resistance in Breast Cancer. PMID:27581354
FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib. PMID:27581340
Nonhistone Lysine Methylation in the Regulation of Cancer Pathways. PMID:27580749
A PGC1α-mediated transcriptional axis suppresses melanoma metastasis. PMID:27580028
Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy. PMID:27577169
Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors. PMID:27572108
RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation. PMID:27571409
Expression and clinicopathological implication of DcR3 in lung cancer tissues: a tissue microarray study with 365 cases. PMID:27570459
Expression of a novel endothelial marker, C-type lectin 14A, in epithelial ovarian cancer and its prognostic significance. PMID:27567920
Microarray-based identification of genes associated with cancer progression and prognosis in hepatocellular carcinoma. PMID:27567667
Identification of breast cancer recurrence risk factors based on functional pathways in tumor and normal tissues. PMID:27564264
Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface. PMID:27563818
Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53. PMID:27559130
Identification of breast cancer cell subtypes sensitive to ATG4B inhibition. PMID:27556700
Concordance of copy number loss and down-regulation of tumor suppressor genes: a pan-cancer study. PMID:27556634
Integrative analysis of somatic mutations and transcriptomic data to functionally stratify breast cancer patients. PMID:27556157
Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer. PMID:27555231
Genetic determinants in head and neck squamous cell carcinoma and their influence on global personalized medicine. PMID:27551333
Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. PMID:27551064
Elucidating Genomic Characteristics of Lung Cancer Progression from In Situ to Invasive Adenocarcinoma. PMID:27545006
Activation of GRP/GRP-R signaling contributes to castration-resistant prostate cancer progression. PMID:27542219
A new correlation clustering method for cancer mutation analysis. PMID:27540270
The Non-coding Mammary Carcinoma Susceptibility Locus, Mcs5c, Regulates Pappa Expression via Age-Specific Chromatin Folding and Allele-Dependent DNA Methylation. PMID:27537370
Gene Coexpression Analyses Differentiate Networks Associated with Diverse Cancers Harboring TP53 Missense or Null Mutations. PMID:27536319
Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models. PMID:27535970
Mixed Mesonephric Adenocarcinoma and High-grade Neuroendocrine Carcinoma of the Uterine Cervix: Case Description of a Previously Unreported Entity With Insights Into Its Molecular Pathogenesis. PMID:27532149
Novel B55α-PP2A mutations in AML promote AKT T308 phosphorylation and sensitivity to AKT inhibitor-induced growth arrest. PMID:27531894
Clinical utility and treatment outcome of comprehensive genomic profiling in high grade glioma patients. PMID:27531351
Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation. PMID:27528607
DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer. PMID:27520310
Dual Chromatin and Cytoskeletal Remodeling by SETD2. PMID:27518565
Genetic variants of the Wnt signaling pathway as predictors of aggressive disease and reclassification in men with early stage prostate cancer on active surveillance. PMID:27515962
Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia. PMID:27510297
HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma. PMID:27506904
In silico modeling for tumor growth visualization. PMID:27503052
Imaging-genomics reveals driving pathways of MRI derived volumetric tumor phenotype features in Glioblastoma. PMID:27502180
Cancer Clocks Out for Lunch: Disruption of Circadian Rhythm and Metabolic Oscillation in Cancer. PMID:27500134
In-depth molecular profiling of the biphasic components of uterine carcinosarcomas. PMID:27499902
High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML. PMID:27498870
Epigenetic activation of LY6K predicts the presence of metastasis and poor prognosis in breast carcinoma. PMID:27494879
The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts. PMID:27494403
Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer. PMID:27491809
Significance of BMI1 and FSCN1 expression in colorectal cancer. PMID:27488323
The microRNA signature of patients with sunitinib failure: regulation of UHRF1 pathways by microRNA-101 in renal cell carcinoma. PMID:27487138
Mammary epithelial morphogenesis and early breast cancer. Evidence of involvement of basal components of the RNA Polymerase I transcription machinery. PMID:27485818
PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs). PMID:27481946
A gene browser of colorectal cancer with literature evidence and pre-computed regulatory information to identify key tumor suppressors and oncogenes. PMID:27477450
Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth. PMID:27477273
EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance. PMID:27470974
SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2. PMID:27469115
Vitamin D Deficiency Promotes Liver Tumor Growth in Transforming Growth Factor-β/Smad3-Deficient Mice Through Wnt and Toll-like Receptor 7 Pathway Modulation. PMID:27456065
Prognostic relevance of autophagy-related markers LC3, p62/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status. PMID:27444698
Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer. PMID:27440266
Examination of CK2α and NF-κB p65 expression in human benign prostatic hyperplasia and prostate cancer tissues. PMID:27435858
Cardiac glycosides display selective efficacy for STK11 mutant lung cancer. PMID:27431571
Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation. PMID:27431380
Epigenetic activation of MGAT3 and corresponding bisecting GlcNAc shortens the survival of cancer patients. PMID:27429195
Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer. PMID:27428427
Phenotypic plasticity in prostate cancer: role of intrinsically disordered proteins. PMID:27427552
TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects. PMID:27425591
Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection. PMID:27424183
The role of wild type RAS isoforms in cancer. PMID:27422332
RNASeq analysis reveals biological processes governing the clinical behaviour of endometrioid and serous endometrial cancers. PMID:27420608
A novel gene expression-based prognostic scoring system to predict survival in gastric cancer. PMID:27419373
Regulation and function of AMPK in physiology and diseases. PMID:27416781
The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer. PMID:27413115
Regulation of TAZ in cancer. PMID:27412635
IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin. PMID:27411958
Myotubularin-related protein 7 inhibits insulin signaling in colorectal cancer. PMID:27409167
Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks. PMID:27403431
A comprehensive next generation sequencing-based virome assessment in brain tissue suggests no major virus - tumor association. PMID:27402152
Causes and consequences of nuclear envelope alterations in tumour progression. PMID:27397692
Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. PMID:27393618
Non-myogenic tumors display altered expression of dystrophin (DMD) and a high frequency of genetic alterations. PMID:27391342
Whole Genome Pathway Analysis Identifies an Association of Cadmium Response Gene Loss with Copy Number Variation in Mutant p53 Bearing Uterine Endometrial Carcinomas. PMID:27391266
MET Inhibition in Clear Cell Renal Cell Carcinoma. PMID:27390595
TMPRSS4 induces invasion and proliferation of prostate cancer cells through induction of Slug and cyclin D1. PMID:27385093
Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3-MYC Interactions as a Target in Pancreatic Cancer. PMID:27384421
RAB25 expression is epigenetically downregulated in oral and oropharyngeal squamous cell carcinoma with lymph node metastasis. PMID:27379752
The dual role of FOXF2 in regulation of DNA replication and the epithelial-mesenchymal transition in breast cancer progression. PMID:27377963
Co-Expression Network Analysis of Fbxw7-Associated LncRNAs Reveals Their Functions in Radiation-Induced Thymic Lymphoma. PMID:27376155
ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways. PMID:27374177
BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. PMID:27373334
Genomic Landscape of poorly Differentiated and Anaplastic Thyroid Carcinoma. PMID:27372303
HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment. PMID:27370607
Combined genetic and epigenetic interferences with interferon signaling expose prostate cancer cells to viral infection. PMID:27366948
Deep Genetic Connection Between Cancer and Developmental Disorders. PMID:27363847
Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma. PMID:27363021
CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. PMID:27358011
Network Modeling Identifies Patient-specific Pathways in Glioblastoma. PMID:27354287
Sterol Regulatory Element Binding Protein Regulates the Expression and Metabolic Functions of Wild-Type and Oncogenic IDH1. PMID:27354064
Silencing of ZRF1 impedes survival of estrogen receptor positive MCF-7 cells and potentiates the effect of curcumin. PMID:27350366
MonoSeq Variant Caller Reveals Novel Mononucleotide Run Indel Mutations in Tumors with Defective DNA Mismatch Repair. PMID:27346418
FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis. PMID:27346356
Cbx8 Acts Non-canonically with Wdr5 to Promote Mammary Tumorigenesis. PMID:27346354
PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2. PMID:27345410
The value of genomics in dissecting the RAS-network and in guiding therapeutics for RAS-driven cancers. PMID:27338857
Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma. PMID:27333051
Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings. PMID:27330277
MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis. PMID:27330189
Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma. PMID:27329590
Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End. PMID:27329033
Pharmacological activation of wild-type p53 in the therapy of leukemia. PMID:27327543
PRAME expression and promoter hypomethylation in epithelial ovarian cancer. PMID:27322684
Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer. PMID:27322458
Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3. PMID:27319316
GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis. PMID:27312530
Approaches to uncovering cancer diagnostic and prognostic molecular signatures. PMID:27308330
Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes. PMID:27304678
Frequent PIK3CA Mutations in Colorectal and Endometrial Tumors With 2 or More Somatic Mutations in Mismatch Repair Genes. PMID:27302833
Tumor and Plasma Met Levels in Non-Metastatic Prostate Cancer. PMID:27300295
Upregulation of AKT3 Confers Resistance to the AKT Inhibitor MK2206 in Breast Cancer. PMID:27297869
Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine. PMID:27296290
Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth. PMID:27292643
The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer. PMID:27292261
Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma. PMID:27287018
Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1. PMID:27286452
WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck. PMID:27285764
A microscopic landscape of the invasive breast cancer genome. PMID:27283966
Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo. PMID:27283899
Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator. PMID:27282385
Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3. PMID:27281824
Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis. PMID:27281560
CRAF R391W is a melanoma driver oncogene. PMID:27273450
NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-κB pathway. PMID:27270613
Myeloid translocation genes differentially regulate colorectal cancer programs. PMID:27270437
Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary. PMID:27270435
Clonal evolution of glioblastoma under therapy. PMID:27270107
Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned. PMID:27255914
Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice. PMID:27255182
Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2α Kinase Levels in NRAS(Q61) Mutant Cells. PMID:27251789
Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis. PMID:27248819
Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism. PMID:27248322
XPA: A key scaffold for human nucleotide excision repair. PMID:27247238
Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells. PMID:27246979
Engineered Swine Models of Cancer. PMID:27242889
Genomic Characterization of High-Grade Serous Ovarian Cancer: Dissecting Its Molecular Heterogeneity as a Road Towards Effective Therapeutic Strategies. PMID:27241520
CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment. PMID:27241286
Checkpoint Inhibitors and Their Application in Breast Cancer. PMID:27239172
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation. PMID:27233495
Functional/activity network (FAN) analysis of gene-phenotype connectivity liaised by grape polyphenol resveratrol. PMID:27232943
The lncRNA PVT1 Contributes to the Cervical Cancer Phenotype and Associates with Poor Patient Prognosis. PMID:27232880
Connexin and pannexin channels in cancer. PMID:27229305
Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma. PMID:27226552
Genomic Landscape of Colorectal Mucosa and Adenomas. PMID:27221540
Reduced SOD2 expression is associated with mortality of hepatocellular carcinoma patients in a mutant p53-dependent manner. PMID:27221200
FAM83 proteins: Fostering new interactions to drive oncogenic signaling and therapeutic resistance. PMID:27221039
Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles. PMID:27220849
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis. PMID:27219062
The metabolic co-regulator PGC1α suppresses prostate cancer metastasis. PMID:27214280
RhoE/ROCK2 regulates chemoresistance through NF-κB/IL-6/ STAT3 signaling in hepatocellular carcinoma. PMID:27213590
REC8 functions as a tumor suppressor and is epigenetically downregulated in gastric cancer, especially in EBV-positive subtype. PMID:27212034
Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer. PMID:27205883
Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. PMID:27203177
Pan-cancer analyses of the nuclear receptor superfamily. PMID:27200367
Reconstruction of gene regulatory networks reveals chromatin remodelers and key transcription factors in tumorigenesis. PMID:27198694
Increased Expression of miR-23a Mediates a Loss of Expression in the RAF Kinase Inhibitor Protein RKIP. PMID:27197200
Infiltrating T Cells Promote Bladder Cancer Progression via Increasing IL1→Androgen Receptor→HIF1α→VEGFa Signals. PMID:27196763
GRK3 is a direct target of CREB activation and regulates neuroendocrine differentiation of prostate cancer cells. PMID:27191986
SETD2: an epigenetic modifier with tumor suppressor functionality. PMID:27191891
Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) interacts with estrogen receptor and predicted poor survival in breast cancer. PMID:27191888
Anti-tumor efficacy of BEZ235 is complemented by its anti-angiogenic effects via downregulation of PI3K-mTOR-HIF1alpha signaling in HER2-defined breast cancers. PMID:27186427
The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma. PMID:27184927
Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo. PMID:27182052
p27T187A knockin identifies Skp2/Cks1 pocket inhibitors for advanced prostate cancer. PMID:27181203
An unregulated regulator: Vasa expression in the development of somatic cells and in tumorigenesis. PMID:27179696
DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers. PMID:27174913
Identifying and targeting determinants of melanoma cellular invasion. PMID:27172792
Coexistence of YWHAZ amplification predicts better prognosis in muscle-invasive bladder cancer with CDKN2A or TP53 loss. PMID:27167196
Squamous Cell Cancers: A Unified Perspective on Biology and Genetics. PMID:27165741
FOXM1 and FOXQ1 Are Promising Prognostic Biomarkers and Novel Targets of Tumor-Suppressive miR-342 in Human Colorectal Cancer. PMID:27162244
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes. PMID:27161491
Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth. PMID:27160768
Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. PMID:27160553
Gender Specific Differences in RNA Polymerase III Transcription. PMID:27158556
Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers. PMID:27158381
A New Approach for Identification of Cancer-related Pathways using Protein Networks and Genomic Data. PMID:27158220
Analyzing Somatic Genome Rearrangements in Human Cancers by Using Whole-Exome Sequencing. PMID:27153396
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. PMID:27150562
Molecular analysis of a male breast cancer patient with prolonged stable disease under mTOR/PI3K inhibitors BEZ235/everolimus. PMID:27148582
Collecting duct carcinoma of the kidney is associated with CDKN2A deletion and SLC family gene up-regulation. PMID:27144525
Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters. PMID:27144334
Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma. PMID:27144065
Alterations in genes other than EGFR/ALK/ROS1 in non-small cell lung cancer: trials and treatment options. PMID:27144064
Hawaii natural compounds are promising to reduce ovarian cancer deaths. PMID:27142977
The Therapeutic Potential of Targeting the HGF/cMET Axis in Ovarian Cancer. PMID:27139908
MET inhibition overcomes radiation resistance of glioblastoma stem-like cells. PMID:27138567
Pan-Cancer Analysis of Mutation Hotspots in Protein Domains. PMID:27135912
An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation. PMID:27135738
Zinc Finger Homeodomain Factor Zfhx3 Is Essential for Mammary Lactogenic Differentiation by Maintaining Prolactin Signaling Activity. PMID:27129249
GCGene: a gene resource for gastric cancer with literature evidence. PMID:27127885
Data Requirements for Model-Based Cancer Prognosis Prediction. PMID:27127404
Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition. PMID:27120806
MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1. PMID:27119506
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. PMID:27117709
VDAC2-specific cellular functions and the underlying structure. PMID:27116927
BMP2/BMPR1A is linked to tumour progression in dedifferentiated liposarcomas. PMID:27114889
Defining actionable mutations for oncology therapeutic development. PMID:27112209
Elevated integrin α6β4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer. PMID:27107458
Deregulation of Rho GTPases in cancer. PMID:27104658
TET2 Negatively Regulates Nestin Expression in Human Melanoma. PMID:27102770
The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma. PMID:27102439
Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma. PMID:27102295
Omics Profiling in Precision Oncology. PMID:27099341
Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas. PMID:27096031
Thin and thick primary cutaneous melanomas reveal distinct patterns of somatic copy number alterations. PMID:27095580
Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets. PMID:27091990
Gastric Lgr5(+) stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice. PMID:27091432
The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy. PMID:27089238
Cerebellum Development and Tumorigenesis: A p53-Centric Perspective. PMID:27085812
Mutation Yield of a 34-Gene Solid Tumor Panel in Community-Based Tumor Samples. PMID:27084556
Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma. PMID:27083054
Integrating Genomics Into Clinical Pediatric Oncology Using the Molecular Tumor Board at the Memorial Sloan Kettering Cancer Center. PMID:27082517
ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion. PMID:27081041
Comprehensive analysis of lncRNA expression profiles reveals a novel lncRNA signature to discriminate nonequivalent outcomes in patients with ovarian cancer. PMID:27074572
Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia. PMID:27071307
The tandem duplicator phenotype as a distinct genomic configuration in cancer. PMID:27071093
Epigenetic and genetic burden measures are associated with tumor characteristics in invasive breast carcinoma. PMID:27070496
VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research. PMID:27060149
FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases. PMID:27060136
Critical role of DEK and its regulation in tumorigenesis and metastasis of hepatocellular carcinoma. PMID:27057626
Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism. PMID:27056547
Bioinformatic exploration of MTA1-regulated gene networks in colon cancer. PMID:27052252
Regulation of Cancer Cell Behavior by the Small GTPase Rab13. PMID:27044746
TGF-β signaling in liver and gastrointestinal cancers. PMID:27039259
Expression of epithelial-mesenchymal transition-related genes increases with copy number in multiple cancer types. PMID:27029057
Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype. PMID:27026680
The Roles of MDM2 and MDMX in Cancer. PMID:27022975
Automated eligibility screening and monitoring for genotype-driven precision oncology trials. PMID:27016727
Chaperonin Containing TCP-1 Protein Level in Breast Cancer Cells Predicts Therapeutic Application of a Cytotoxic Peptide. PMID:27012814
Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer. PMID:27005559
TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene. PMID:27005522
Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer. PMID:27004849
Plasminogen activator inhibitor-1 enhances radioresistance and aggressiveness of non-small cell lung cancer cells. PMID:27004408
Genomic landscape of DNA repair genes in cancer. PMID:27004405
AR-42 induces apoptosis in human hepatocellular carcinoma cells via HDAC5 inhibition. PMID:26993777
Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation. PMID:26993606
Transforming Growth Factor-β Is an Upstream Regulator of Mammalian Target of Rapamycin Complex 2-Dependent Bladder Cancer Cell Migration and Invasion. PMID:26988652
p53MutaGene: an online tool to estimate the effect of p53 mutational status on gene regulation in cancer. PMID:26986515
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. PMID:26982726
Mutation based treatment recommendations from next generation sequencing data: a comparison of web tools. PMID:26980737
Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways. PMID:26977886
Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma. PMID:26977885
Cancer genomics: opportunities for medicinal chemistry? PMID:26976526
REGene: a literature-based knowledgebase of animal regeneration that bridge tissue regeneration and cancer. PMID:26975833
Stathmin involvement in the maternal embryonic leucine zipper kinase pathway in glioblastoma. PMID:26973435
MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma. PMID:26967478
Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1. PMID:26966246
12-HETER1/GPR31, a high-affinity 12(S)-hydroxyeicosatetraenoic acid receptor, is significantly up-regulated in prostate cancer and plays a critical role in prostate cancer progression. PMID:26965684
Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment. PMID:26965581
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. PMID:26960398
Reciprocal positive selection for weakness - preventing olaparib resistance by inhibiting BRCA2. PMID:26959114
The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer. PMID:26957540
Distinct Metabolic Signature of Human Bladder Cancer Cells Carrying an Impaired Fanconi Anemia Tumor-Suppressor Signaling Pathway. PMID:26956768
Improving gastric cancer preclinical studies using diverse in vitro and in vivo model systems. PMID:26955870
DNA methylation modifies the association between obesity and survival after breast cancer diagnosis. PMID:26945992
The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation. PMID:26943038
Long non-coding RNAs as prognostic markers in human breast cancer. PMID:26942882
FGFR1 promotes the stem cell-like phenotype of FGFR1-amplified non-small cell lung cancer cells through the Hedgehog pathway. PMID:26936993
ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma. PMID:26936505
Activation-Induced Cytidine Deaminase Links Ovulation-Induced Inflammation and Serous Carcinogenesis. PMID:26936395
Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression. PMID:26934321
AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours. PMID:26934201
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. PMID:26928227
SOX5 is involved in balanced MITF regulation in human melanoma cells. PMID:26927636
Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition. PMID:26926107
Clinical impact of tumour biology in the management of gastroesophageal cancer. PMID:26925958
Mutational Landscape of Aggressive Prostate Tumors in African American Men. PMID:26921337
Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival. PMID:26921331
The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair. PMID:26915295
Mutations in PIK3CA sensitize breast cancer cells to physiologic levels of aspirin. PMID:26915040
Prevalence and phenotypic correlations of EIF1AX mutations in thyroid nodules. PMID:26911375
Elevated expression of IFN-inducible CXCR3 ligands predicts poor prognosis in patients with non-metastatic clear-cell renal cell carcinoma. PMID:26910919
MiR-494 Inhibits Epithelial Ovarian Cancer Growth by Targeting c-Myc. PMID:26908019
Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells. PMID:26907172
Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs. PMID:26906009
Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion. PMID:26895380
Association between cytoplasmic CRABP2, altered retinoic acid signaling, and poor prognosis in glioblastoma. PMID:26893190
GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification. PMID:26887977
MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells. PMID:26885614
Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling. PMID:26884713
Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients. PMID:26884349
Discovery of candidate tumor biomarkers for treatment with intraperitoneal chemotherapy for ovarian cancer. PMID:26883286
Involvement of calprotectin (S100A8/A9) in molecular pathways associated with HNSCC. PMID:26883112
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination. PMID:26881969
Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators. PMID:26879975
BCORL1 is an independent prognostic marker and contributes to cell migration and invasion in human hepatocellular carcinoma. PMID:26879601
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers. PMID:26878173
BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1. PMID:26877780
High Expression of miR-532-5p, a Tumor Suppressor, Leads to Better Prognosis in Ovarian Cancer Both In Vivo and In Vitro. PMID:26873729
The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells. PMID:26871602
Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway. PMID:26871431
Structure, expression and functions of MTA genes. PMID:26869315
Transcription factor C/EBP-β induces tumor-suppressor phosphatase PHLPP2 through repression of the miR-17-92 cluster in differentiating AML cells. PMID:26868909
Integrative modeling of multi-omics data to identify cancer drivers and infer patient-specific gene activity. PMID:26864072
Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome. PMID:26862846
G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling. PMID:26861299
LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer. PMID:26860319
Clinical Overview of MDM2/X-Targeted Therapies. PMID:26858935
Differential expression of PDGFRB and EGFR in microvascular proliferation in glioblastoma. PMID:26857280
Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma. PMID:26855149
Web-TCGA: an online platform for integrated analysis of molecular cancer data sets. PMID:26852330
Moving towards personalised therapy in head and neck squamous cell carcinoma through analysis of next generation sequencing data. PMID:26851381
Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells. PMID:26848584
The effect of HMGB1 on the clinicopathological and prognostic features of non-small cell lung cancer. PMID:26840258
A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer. PMID:26840086
Imaging-genomic pipeline for identifying gene mutations using three-dimensional intra-tumor heterogeneity features. PMID:26839909
Targeting TRPM2 Channels Impairs Radiation-Induced Cell Cycle Arrest and Fosters Cell Death of T Cell Leukemia Cells in a Bcl-2-Dependent Manner. PMID:26839633
The rs11515 Polymorphism Is More Frequent and Associated With Aggressive Breast Tumors with Increased ANRIL and Decreased p16 (INK4a) Expression. PMID:26835415
MLL1 is essential for the senescence-associated secretory phenotype. PMID:26833731
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. PMID:26833729
Targeted Next-Generation Sequencing Identifies a Recurrent Mutation in MCPH1 Associating with Hereditary Breast Cancer Susceptibility. PMID:26820313
Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss. PMID:26818109
Endothelin therapeutics in cancer: Where are we? PMID:26818060
Genomic and epigenomic heterogeneity in molecular subtypes of gastric cancer. PMID:26811657
Mouse models for the discovery of colorectal cancer driver genes. PMID:26811627
Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers. PMID:26810754
Amplification of the bromodomain-containing protein 4 gene in ovarian high-grade serous carcinoma is associated with worse prognosis and survival. PMID:26807235
Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation. PMID:26804919
Mutations of Chromatin Structure Regulating Genes in Human Malignancies. PMID:26796307
Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma. PMID:26790128
Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis. PMID:26785143
TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. PMID:26784546
CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases. PMID:26775705
BRCAness revisited. PMID:26775620
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer. PMID:26771841
ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression. PMID:26771237
Molecular Pathways: AXL, a Membrane Receptor Mediator of Resistance to Therapy. PMID:26763248
GPR171 expression enhances proliferation and metastasis of lung cancer cells. PMID:26760963
Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A. PMID:26760764
SSRP1 Contributes to the Malignancy of Hepatocellular Carcinoma and Is Negatively Regulated by miR-497. PMID:26755331
Direct Calculation of Protein Fitness Landscapes through Computational Protein Design. PMID:26745411
MicroRNA 100 sensitizes luminal A breast cancer cells to paclitaxel treatment in part by targeting mTOR. PMID:26744318
Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry. PMID:26732427
Overview of pre-clinical and clinical studies targeting angiogenesis in pancreatic ductal adenocarcinoma. PMID:26723874
Improved survival associated with somatic PIK3CA mutations in copy-number low endometrioid endometrial adenocarcinoma. PMID:26722235
Structure-Based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors. PMID:26721946
Fibroblast growth factor receptor 3 protein is overexpressed in oral and oropharyngeal squamous cell carcinoma. PMID:26711175
Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer. PMID:26711141
Exploring genomic alteration in pediatric cancer using ProteinPaint. PMID:26711108
TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data. PMID:26704973
TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer. PMID:26702755
The significance of Brf1 overexpression in human hepatocellular carcinoma. PMID:26701855
The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling. PMID:26701726
Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas. PMID:26700204
ECGene: A Literature-Based Knowledgebase of Endometrial Cancer Genes. PMID:26699919
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. PMID:26691987
The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. PMID:26687066
Tumor-suppressor NFκB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494. PMID:26686085
Regulation of breast tumorigenesis through acid sensors. PMID:26686084
EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes. PMID:26683696
Prognostic significance of FAM83D gene expression across human cancer types. PMID:26678035
Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis. PMID:26677978
Onco-proteogenomics identifies urinary S100A9 and GRN as potential combinatorial biomarkers for early diagnosis of hepatocellular carcinoma. PMID:26675302
The emerging role of Slit-Robo pathway in gastric and other gastro intestinal cancers. PMID:26674478
Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity. PMID:26672766
Sources of polycyclic aromatic hydrocarbons are associated with gene-specific promoter methylation in women with breast cancer. PMID:26671626
Mutation Screening of 1,237 Cancer Genes across Six Model Cell Lines of Basal-Like Breast Cancer. PMID:26670335
The Cellular Apoptosis Susceptibility Protein (CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis and Cell Proliferation. PMID:26668314
Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation. PMID:26668268
The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. PMID:26655904
SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status. PMID:26654769
Understanding the role of the kynurenine pathway in human breast cancer immunobiology. PMID:26646699
MicroRNAs 125a and 125b inhibit ovarian cancer cells through post-transcriptional inactivation of EIF4EBP1. PMID:26646586
HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells. PMID:26643866
Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: Repertoire of somatic genetic alterations and clonal relationships. PMID:26643573
DriverDBv2: a database for human cancer driver gene research. PMID:26635391
rcellminer: exploring molecular profiles and drug response of the NCI-60 cell lines in R. PMID:26635141
An integrative somatic mutation analysis to identify pathways linked with survival outcomes across 19 cancer types. PMID:26635139
Different prognostic impact of STK11 mutations in non-squamous non-small-cell lung cancer. PMID:26625312
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. PMID:26619011
Integrated genomic characterization of IDH1-mutant glioma malignant progression. PMID:26618343
Mutant p53: Multiple Mechanisms Define Biologic Activity in Cancer. PMID:26618142
Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility. PMID:26610392
Role of "oncogenic nexus" of CIP2A in breast oncogenesis: how does it work? PMID:26609493
Inhibition of pentose phosphate pathway suppresses acute myelogenous leukemia. PMID:26596840
TSGene 2.0: an updated literature-based knowledgebase for tumor suppressor genes. PMID:26590405
ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. PMID:26590320
An integrated genomic analysis of Tudor domain-containing proteins identifies PHD finger protein 20-like 1 (PHF20L1) as a candidate oncogene in breast cancer. PMID:26588862
Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma. PMID:26576100
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing. PMID:26575292
Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas. PMID:26575021
Induction of proto-oncogene BRF2 in breast cancer cells by the dietary soybean isoflavone daidzein. PMID:26573593
Drosophila Rabex-5 restricts Notch activity in hematopoietic cells and maintains hematopoietic homeostasis. PMID:26567216
Persistent androgen receptor addiction in castration-resistant prostate cancer. PMID:26566796
LINC00472 expression is regulated by promoter methylation and associated with disease-free survival in patients with grade 2 breast cancer. PMID:26564482
Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-κB regulatory genes. PMID:26564005
TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation. PMID:26563938
The potential role of PHF6 as an oncogene: a genotranscriptomic/proteomic meta-analysis. PMID:26561469
TP53 Mutational Spectrum in Endometrioid and Serous Endometrial Cancers. PMID:26556035
Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma. PMID:26554648
Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer. PMID:26553438
CSIOVDB: a microarray gene expression database of epithelial ovarian cancer subtype. PMID:26549805
Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion. PMID:26549256
Co-active receptor tyrosine kinases mitigate the effect of FGFR inhibitors in FGFR1-amplified lung cancers with low FGFR1 protein expression. PMID:26549034
Depletion of three combined THOC5 mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death. PMID:26549021
Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers. PMID:26546618
N-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression. PMID:26537799
Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation. PMID:26531827
MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. PMID:26530832
Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression. PMID:26529257
IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival. PMID:26527316
Metastatic renal cell carcinoma without evidence of a renal primary. PMID:26527083
Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet. PMID:26526858
ATP5A1 and ATP5B are highly expressed in glioblastoma tumor cells and endothelial cells of microvascular proliferation. PMID:26526033
Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers. PMID:26523969
A Database of Gene Expression Profiles of Korean Cancer Genome. PMID:26523133
The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo. PMID:26517239
A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma. PMID:26515236
Lentiviral vector-mediated insertional mutagenesis screen identifies genes that influence androgen independent prostate cancer progression and predict clinical outcome. PMID:26512949
Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation. PMID:26510686
A human leucyl-tRNA synthetase as an anticancer target. PMID:26508878
A novel gammaretroviral shuttle vector insertional mutagenesis screen identifies SHARPIN as a breast cancer metastasis gene and prognostic biomarker. PMID:26506596
The Tip of the Iceberg: Clinical Implications of Genomic Sequencing Projects in Head and Neck Cancer. PMID:26506389
MEF2 transcription factors: developmental regulators and emerging cancer genes. PMID:26506234
A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma. PMID:26504497
Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. PMID:26503472
Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair. PMID:26502057
Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients. PMID:26500237
Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression. PMID:26498686
TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines. PMID:26496938
Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing. PMID:26496030
Genomic characterisation of two cancers of unknown primary cases supports a kidney cancer origin. PMID:26494726
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. PMID:26493647
GREM1 and POLE variants in hereditary colorectal cancer syndromes. PMID:26493165
An evidence-based knowledgebase of metastasis suppressors to identify key pathways relevant to cancer metastasis. PMID:26486520
Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC). PMID:26484545
Oncogenomic portals for the visualization and analysis of genome-wide cancer data. PMID:26484415
Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination. PMID:26475525
Increased metastasis with loss of E2F2 in Myc-driven tumors. PMID:26474282
Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma. PMID:26473374
Targeting Signaling Transduction Pathways in Bladder Cancer. PMID:26472299
Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties. PMID:26468652
Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination. PMID:26464464
The NER-related gene GTF2H5 predicts survival in high-grade serous ovarian cancer patients. PMID:26463438
Public data and open source tools for multi-assay genomic investigation of disease. PMID:26463000
RelA-Induced Interferon Response Negatively Regulates Proliferation. PMID:26460486
JRK is a positive regulator of β-catenin transcriptional activity commonly overexpressed in colon, breast and ovarian cancer. PMID:26455321
Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer. PMID:26452386
UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO. PMID:26449661
Genetic Alterations in Gliosarcoma and Giant Cell Glioblastoma. PMID:26443480
Functional Role of G9a Histone Methyltransferase in Cancer. PMID:26441991
Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway. PMID:26440310
p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase. PMID:26438819
From drug response profiling to target addiction scoring in cancer cell models. PMID:26438695
Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition. PMID:26437225
GNL3 and SKA3 are novel prostate cancer metastasis susceptibility genes. PMID:26429724
A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors. PMID:26428316
Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer. PMID:26427375
Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland. PMID:26426580
Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma. PMID:26424075
Genome-wide association study identifies multiple susceptibility loci for glioma. PMID:26424050
Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. PMID:26420897
CD151 promotes α3β1 integrin-dependent organization of carcinoma cell junctions and restrains collective cell invasion. PMID:26418968
The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression. PMID:26417066
Genomic alterations in BCL2L1 and DLC1 contribute to drug sensitivity in gastric cancer. PMID:26401016
Translational compensation of genomic instability in neuroblastoma. PMID:26399178
KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27kip1. PMID:26397136
Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer. PMID:26390252
Kinome-wide decoding of network-attacking mutations rewiring cancer signaling. PMID:26388441
A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis. PMID:26384344
Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. PMID:26384318
Decreased efficacy of drugs targeting the vascular endothelial growth factor pathway by the epigenetic silencing of FLT1 in renal cancer cells. PMID:26380584
CDK4/6 inhibitor suppresses gastric cancer with CDKN2A mutation. PMID:26380006
Limited evidence that cancer susceptibility regions are preferential targets for somatic mutation. PMID:26374197
Splicing Factor Prp8 Interacts With NES(AR) and Regulates Androgen Receptor in Prostate Cancer Cells. PMID:26371515
RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors. PMID:26370156
Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma. PMID:26369831
YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells. PMID:26364602
hPso4/hPrp19: a critical component of DNA repair and DNA damage checkpoint complexes. PMID:26364595
Gene mutations in gastric cancer: a review of recent next-generation sequencing studies. PMID:26364057
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type. PMID:26356327
Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants. PMID:26354769
Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. PMID:26354767
Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. PMID:26353928
DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines. PMID:26353782
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B. PMID:26344709
Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14. PMID:26341486
NF-κB: Regulation by Methylation. PMID:26337909
Targeted genomic profiling reveals recurrent KRAS mutations and gain of chromosome 1q in mesonephric carcinomas of the female genital tract. PMID:26336887
The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma. PMID:26336132
NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability. PMID:26324937
Extreme Outlier Analysis Identifies Occult Mitogen-Activated Protein Kinase Pathway Mutations in Patients With Low-Grade Serous Ovarian Cancer. PMID:26324360
Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation. PMID:26322231
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. PMID:26321681
Cancer Driver Log (CanDL): Catalog of Potentially Actionable Cancer Mutations. PMID:26320871
Precision medicine at Memorial Sloan Kettering Cancer Center: clinical next-generation sequencing enabling next-generation targeted therapy trials. PMID:26320725
Genomic copy number analysis of Chernobyl papillary thyroid carcinoma in the Ukrainian-American Cohort. PMID:26320103
KRAS mutations in microsatellite instable gastric tumours: impact of targeted treatment and intratumoural heterogeneity. PMID:26318594
Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells. PMID:26318585
Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux. PMID:26312386
Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomes. PMID:26307061
Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. PMID:26305679
The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics. PMID:26300004
Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance. PMID:26299805
Identification of a PEAK1/ZEB1 signaling axis during TGFβ/fibronectin-induced EMT in breast cancer. PMID:26297948
Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer. PMID:26297050
Predicting Response to Histone Deacetylase Inhibitors Using High-Throughput Genomics. PMID:26296641
YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers. PMID:26295846
Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression. PMID:26294211
Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase. PMID:26292256
Pyrosequencing-Based Assays for Rapid Detection of HER2 and HER3 Mutations in Clinical Samples Uncover an E332E Mutation Affecting HER3 in Retroperitoneal Leiomyosarcoma. PMID:26287187
OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation. PMID:26283179
Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. PMID:26280536
Ras association domain family member 10 suppresses gastric cancer growth by cooperating with GSTP1 to regulate JNK/c-Jun/AP-1 pathway. PMID:26279301
TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling. PMID:26268696
Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer. PMID:26267899
Activating Mutations in PIK3CA Lead to Widespread Modulation of the Tyrosine Phosphoproteome. PMID:26267517
Phospho-T356RB1 predicts survival in HPV-negative squamous cell carcinoma of the head and neck. PMID:26265441
Search for new loci and low-frequency variants influencing glioma risk by exome-array analysis. PMID:26264438
Cancer Cell Line Panels Empower Genomics-Based Discovery of Precision Cancer Medicine. PMID:26256959
Point mutations of the mTOR-RHEB pathway in renal cell carcinoma. PMID:26255626
The molecular landscape of premenopausal breast cancer. PMID:26251034
MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation. PMID:26245647
Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2. PMID:26244988
Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression. PMID:26243836
E-cadherin can limit the transforming properties of activating β-catenin mutations. PMID:26240067
Beclin-1 expression is retained in high-grade serous ovarian cancer yet is not essential for autophagy induction in vitro. PMID:26239434
Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. PMID:26234763
RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression. PMID:26234677
Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis. PMID:26233892
The PI3K/AKT Pathway and Renal Cell Carcinoma. PMID:26233890
Cancer type-dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types. PMID:26227665
Model-Based Design of a Decision Tree for Treating HER2+ Cancers Based on Genetic and Protein Biomarkers. PMID:26225238
Role of microRNAs Located on Chromosome Arm 10q in Malignant Gliomas. PMID:26223576
Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells. PMID:26222502
Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomas. PMID:26221190
Downregulation of dystroglycan glycosyltransferases LARGE2 and ISPD associate with increased mortality in clear cell renal cell carcinoma. PMID:26220087
Survival of patients with structurally-grouped TP53 mutations in ovarian and breast cancers. PMID:26215675
Alternative preprocessing of RNA-Sequencing data in The Cancer Genome Atlas leads to improved analysis results. PMID:26209429
Cross-cancer profiling of molecular alterations within the human autophagy interaction network. PMID:26208877
LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer. PMID:26208723
Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer. PMID:26207617
Dysregulation of the Met pathway in non-small cell lung cancer: implications for drug targeting and resistance. PMID:26207212
Clinicopathologic implications of NF1 gene alterations in diffuse gliomas. PMID:26190195
CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma. PMID:26183406
RAC1 P29S regulates PD-L1 expression in melanoma. PMID:26176707
Poly (A) Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor. PMID:26176602
Analysis of gene expression of secreted factors associated with breast cancer metastases in breast cancer subtypes. PMID:26173622
Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma. PMID:26172295
Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma. PMID:26168291
Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma. PMID:26164206
TGFβ-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis. PMID:26157579
High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer. PMID:26156018
Time-course gene profiling and networks in demethylated retinoblastoma cell line. PMID:26143641
Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer. PMID:26140362
Integrative network analysis for survival-associated gene-gene interactions across multiple genomic profiles in ovarian cancer. PMID:26138921
Plakophilin 1-deficient cells upregulate SPOCK1: implications for prostate cancer progression. PMID:26138584
Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer. PMID:26121593
Heat-shock factor 2 is a suppressor of prostate cancer invasion. PMID:26119944
Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer. PMID:26113876
Computational methods and resources for the interpretation of genomic variants in cancer. PMID:26111056
Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer. PMID:26110843
Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas. PMID:26109333
The expression of microRNA-34a is inversely correlated with c-MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients. PMID:26104764
Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer. PMID:26101715
The Therapeutic Challenge of Targeting HER2 in Endometrial Cancer. PMID:26099744
dbEMT: an epithelial-mesenchymal transition associated gene resource. PMID:26099468
DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45 (CT45) genes is associated with disease progression and reduced survival in epithelial ovarian cancer. PMID:26098711
Genomic landscape of adenoid cystic carcinoma of the breast. PMID:26095796
A Single Kinase Generates the Majority of the Secreted Phosphoproteome. PMID:26091039
Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach. PMID:26084042
NF1 Mutations Are Common in Desmoplastic Melanoma. PMID:26076063
An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes. PMID:26075792
Pedican: an online gene resource for pediatric cancers with literature evidence. PMID:26073932
Novel EPHB4 Receptor Tyrosine Kinase Mutations and Kinomic Pathway Analysis in Lung Cancer. PMID:26073592
Regulation and function of the human HSP90AA1 gene. PMID:26071189
Structural Determinants of the Mechanical Stability of α-Catenin. PMID:26070562
Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas. PMID:26070366
Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids. PMID:26068970
Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation. PMID:26065894
A critical role for HER3 in HER2-amplified and non-amplified breast cancers: function of a kinase-dead RTK. PMID:26064441
Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. PMID:26062848
Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women. PMID:26053184
Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. PMID:26047463
Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells. PMID:26036626
Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAF(V600E) Melanoma. PMID:26032958
Consistent copy number changes and recurrent PRKAR1A mutations distinguish Melanotic Schwannomas from Melanomas: SNP-array and next generation sequencing analysis. PMID:26031761
Prostate-specific G-protein-coupled receptor collaborates with loss of PTEN to promote prostate cancer progression. PMID:26028029
Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. PMID:26028026
EGFR blockade prevents glioma escape from BRAFV600E targeted therapy. PMID:26023796
mTORC1 signaling activates NRF1 to increase cellular proteasome levels. PMID:26017155
The CASC15 Long Intergenic Noncoding RNA Locus Is Involved in Melanoma Progression and Phenotype Switching. PMID:26016895
Combined Inhibition of MEK and Plk1 Has Synergistic Antitumor Activity in NRAS Mutant Melanoma. PMID:26016894
Mutated Fanconi anemia pathway in non-Fanconi anemia cancers. PMID:26015400
The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast: an exploratory, hypothesis-generating study. PMID:26011570
TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis. PMID:26001956
Integrative clinical genomics of advanced prostate cancer. PMID:26000489
Identification of differentially methylated markers among cytogenetic risk groups of acute myeloid leukemia. PMID:25996682
FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus Replication in Hepatoma Cells by Regulating Tumor Suppressor p53. PMID:25995247
Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression. PMID:25993413
Expression of polarity genes in human cancer. PMID:25991909
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. PMID:25990418
Genomic Analysis of the BMP Family in Glioblastomas. PMID:25987829
Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis. PMID:25987130
IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG. PMID:25982283
Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression. PMID:25977291
Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping. PMID:25971939
Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics. PMID:25970776
Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib. PMID:25969993
TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas. PMID:25958320
Zodiac: A Comprehensive Depiction of Genetic Interactions in Cancer by Integrating TCGA Data. PMID:25956356
Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies. PMID:25956158
Efficient exploration of pan-cancer networks by generalized covariance selection and interactive web content. PMID:25953855
A method for generating new datasets based on copy number for cancer analysis. PMID:25949998
An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy. PMID:25949894
New recurrent BRCA1/2 mutations in Polish patients with familial breast/ovarian cancer detected by next generation sequencing. PMID:25948282
Activation of insulin-like growth factor 1 receptor in patients with non-small cell lung cancer. PMID:25944691
Pregnancy associated plasma protein-A links pregnancy and melanoma progression by promoting cellular migration and invasion. PMID:25940796
HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses. PMID:25938541
Low ATM protein expression in malignant tumor as well as cancer-associated stroma are independent prognostic factors in a retrospective study of early-stage hormone-negative breast cancer. PMID:25935535
IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma. PMID:25934889
Predicting human genetic interactions from cancer genome evolution. PMID:25933428
Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells. PMID:25926557
Genetic and molecular analyses reveal G6PC as a key element connecting glucose metabolism and cell cycle control in ovarian cancer. PMID:25926381
Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma. PMID:25925892
Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN. PMID:25925379
Structural mechanisms of DREAM complex assembly and regulation. PMID:25917549
Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining. PMID:25916843
ERBB4 is over-expressed in human colon cancer and enhances cellular transformation. PMID:25916654
Origin of cells and network information. PMID:25914760
N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects. PMID:25914051
Molecular stratification of metastatic melanoma using gene expression profiling: Prediction of survival outcome and benefit from molecular targeted therapy. PMID:25909218
Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer. PMID:25903835
TFF2-CXCR4 Axis Is Associated with BRAF V600E Colon Cancer. PMID:25899003
MET Mutation Associated with Responsiveness to Crizotinib. PMID:25898962
HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer. PMID:25897424
KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulation. PMID:25896712
Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity. PMID:25883215
Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer. PMID:25879784
Genomic alterations in DNA repair and chromatin remodeling genes in estrogen receptor-positive metastatic breast cancer patients with exceptional responses to capecitabine. PMID:25871911
Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer. PMID:25865225
A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine. PMID:25860647
PI3Kβ inhibitor TGX221 selectively inhibits renal cell carcinoma cells with both VHL and SETD2 mutations and links multiple pathways. PMID:25853938
The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling. PMID:25851810
Studying clonal dynamics in response to cancer therapy using high-complexity barcoding. PMID:25849130
Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics. PMID:25849106
Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin. PMID:25846096
Promoter hypermethylation profiling of distant breast cancer metastases. PMID:25841351
Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolism in clear cell renal cell carcinoma. PMID:25830305
Modulation of Macrophage Gene Expression via Liver X Receptor α Serine 198 Phosphorylation. PMID:25825525
The expression of DBC1/CCAR2 is associated with poor prognosis of ovarian carcinoma. PMID:25823848
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. PMID:25822087
BioXpress: an integrated RNA-seq-derived gene expression database for pan-cancer analysis. PMID:25819073
Mutant p53 expression in fallopian tube epithelium drives cell migration. PMID:25810107
Loss of PLZF expression in prostate cancer by immunohistochemistry correlates with tumor aggressiveness and metastasis. PMID:25807461
Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer. PMID:25789974
Genetic interaction between Tmprss2-ERG gene fusion and Nkx3.1-loss does not enhance prostate tumorigenesis in mouse models. PMID:25780911
Coordinate loss of MAP3K7 and CHD1 promotes aggressive prostate cancer. PMID:25770290
p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration. PMID:25753393
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. PMID:25748654
ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels. PMID:25742469
Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis. PMID:25740784
Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4. PMID:25737278
APOBEC3B expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation. PMID:25730878
DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior. PMID:25713415
Databases and web tools for cancer genomics study. PMID:25707591
Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells. PMID:25703587
Disease implications of the Hippo/YAP pathway. PMID:25702974
Methodological aspects of the molecular and histological study of prostate cancer: focus on PTEN. PMID:25697760
DNMT3A in haematological malignancies. PMID:25693834
The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge. PMID:25691825
A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells. PMID:25681440
Lung Master Protocol (Lung-MAP)-A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400. PMID:25680375
Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity. PMID:25673823
La FAM fatale: USP9X in development and disease. PMID:25672900
A leak pathway for luminal protons in endosomes drives oncogenic signalling in glioblastoma. PMID:25662504
The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond. PMID:25662273
p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. PMID:25659586
Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PMID:25658639
In silico functional pathway annotation of 86 established prostate cancer risk variants. PMID:25658610
The functional and pathologic relevance of autophagy proteases. PMID:25654548
Beclin 1 regulates growth factor receptor signaling in breast cancer. PMID:25639875
HMG20A is required for SNAI1-mediated epithelial to mesenchymal transition. PMID:25639869
A unique subset of epithelial ovarian cancers with platinum sensitivity and PARP inhibitor resistance. PMID:25634215
MYC-xing it up with PIK3CA mutation and resistance to PI3K inhibitors: summit of two giants in breast cancers. PMID:25628917
Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling. PMID:25625625
Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy? PMID:25621172
Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. PMID:25619690
NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. PMID:25611383
Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer. PMID:25605014
Rapid in vivo validation of candidate drivers derived from the PTEN-mutant prostate metastasis genome. PMID:25592467
MYC regulates the non-coding transcriptome. PMID:25587025
Identification of six new susceptibility loci for invasive epithelial ovarian cancer. PMID:25581431
Identification of constrained cancer driver genes based on mutation timing. PMID:25569148
Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS. PMID:25557169
The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges. PMID:25556614
Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein. PMID:25549724
Argininosuccinate synthetase (ASS) deficiency in high-grade pulmonary neuroendocrine carcinoma: an opportunity for personalized targeted therapy. PMID:25548129
A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy. PMID:25544748
Genetic alterations of histone lysine methyltransferases and their significance in breast cancer. PMID:25537518
Characterization of HGF/Met Signaling in Cell Lines Derived From Urothelial Carcinoma of the Bladder. PMID:25534569
STRIPAK components determine mode of cancer cell migration and metastasis. PMID:25531779
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. PMID:25531777
Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness. PMID:25531322
Loss of MLH1 confers resistance to PI3Kβ inhibitors in renal clear cell carcinoma with SETD2 mutation. PMID:25528216
TRKing down an old oncogene in a new era of targeted therapy. PMID:25527197
Evidence for the Influence of the Iron Regulatory MHC Class I Molecule HFE on Tumor Progression in Experimental Models and Clinical Populations. PMID:25520556
Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer. PMID:25519703
Protein disorder: wagging a tail at ubiquitin. PMID:25517385
Loss of the Notch effector RBPJ promotes tumorigenesis. PMID:25512468
Kinome-wide screening of HER2+ breast cancer cells for molecules that mediate cell proliferation or sensitize cells to trastuzumab therapy. PMID:25500906
RSUME inhibits VHL and regulates its tumor suppressor function. PMID:25500545
Oncogenic alterations in ERBB2/HER2 represent potential therapeutic targets across tumors from diverse anatomic sites of origin. PMID:25480824
A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. PMID:25458841
Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer. PMID:25447675
LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression. PMID:25435372
Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1. PMID:25427824
SF3B1 mutations constitute a novel therapeutic target in breast cancer. PMID:25424858
MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers. PMID:25422431
Survival analysis tools in genomics research. PMID:25421963
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. PMID:25415230
A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes. PMID:25411967
Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer. PMID:25410484
Evaluation of an integrated clinical workflow for targeted next-generation sequencing of low-quality tumor DNA using a 51-gene enrichment panel. PMID:25395014
Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations. PMID:25394778
Oncogenic activity of the regulatory subunit p85β of phosphatidylinositol 3-kinase (PI3K). PMID:25385636
Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types. PMID:25383969
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. PMID:25378557
Classification models for clear cell renal carcinoma stage progression, based on tumor RNAseq expression trained supervised machine learning algorithms. PMID:25374611
The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer. PMID:25368431
SOX4 inhibits GBM cell growth and induces G0/G1 cell cycle arrest through Akt-p53 axis. PMID:25366337
MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking. PMID:25351745
CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression. PMID:25333262
Stromal Expression of Fibroblast Activation Protein Alpha (FAP) Predicts Platinum Resistance and Shorter Recurrence in patients with Epithelial Ovarian Cancer. PMID:25331442
miR-154* and miR-379 in the DLK1-DIO3 microRNA mega-cluster regulate epithelial to mesenchymal transition and bone metastasis of prostate cancer. PMID:25324143
Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities. PMID:25314076
Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis. PMID:25306547
Multiple Components of the VHL Tumor Suppressor Complex Are Frequently Affected by DNA Copy Number Loss in Pheochromocytoma. PMID:25298778
A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling. PMID:25296753
Genomically driven precision medicine to improve outcomes in anaplastic thyroid cancer. PMID:25276134
Integrated omic analysis of oropharyngeal carcinomas reveals human papillomavirus (HPV)-dependent regulation of the activator protein 1 (AP-1) pathway. PMID:25271301
Host deficiency in caveolin-2 inhibits lung carcinoma tumor growth by impairing tumor angiogenesis. PMID:25269481
Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. PMID:25252692
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. PMID:25240283
Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response. PMID:25238756
Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC. PMID:25238142
Mutation and Transcriptional Profiling of Formalin-Fixed Paraffin Embedded Specimens as Companion Methods to Immunohistochemistry for Determining Therapeutic Targets in Oropharyngeal Squamous Cell Carcinoma (OPSCC): A Pilot of Proof of Principle. PMID:25236499
Modulation of sodium iodide symporter in thyroid cancer. PMID:25234361
Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma. PMID:25233932
Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia. PMID:25220401
Targeted H3R26 deimination specifically facilitates estrogen receptor binding by modifying nucleosome structure. PMID:25211228
Clinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways. PMID:25206307
Endothelin-1/endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis. PMID:25194819
Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. PMID:25188500
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. PMID:25187556
Prominin-1 (CD133) defines both stem and non-stem cell populations in CNS development and gliomas. PMID:25184684
The LRIG family: enigmatic regulators of growth factor receptor signaling. PMID:25183430
RTCGAToolbox: a new tool for exporting TCGA Firehose data. PMID:25181531
Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. PMID:25178650
ATR inhibition preferentially targets homologous recombination-deficient tumor cells. PMID:25174396
Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells. PMID:25153725
Precision therapy for lymphoma--current state and future directions. PMID:25135367
hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3. PMID:25120384
Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. PMID:25117820
Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer. PMID:25114896
Candidate prognostic markers in breast cancer: focus on extracellular proteases and their inhibitors. PMID:25114586
Available resources and challenges for the clinical annotation of somatic variations. PMID:25111663
PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors. PMID:25103565
Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer. PMID:25096367
Integrating biological pathways and genomic profiles with ChiBE 2. PMID:25086704
Recurring DNA copy number gain at chromosome 9p13 plays a role in the activation of multiple candidate oncogenes in progressing oral premalignant lesions. PMID:25060540
Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer. PMID:25056937
Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma. PMID:25051363
Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast. PMID:25041824
Sox2 gene amplification significantly impacts overall survival in serous epithelial ovarian cancer. PMID:25038052
Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression. PMID:25026213
Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): an oncoprotein with many hands. PMID:25015035
Visualizing molecular profiles of glioblastoma with GBM-BioDP. PMID:25010047
ASXL1 and DNMT3A mutation in a cytogenetically normal B3 thymoma. PMID:25000259
Inhibition of BMP signaling suppresses metastasis in mammary cancer. PMID:24998846
Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer. PMID:24981109
USP33, a new player in lung cancer, mediates Slit-Robo signaling. PMID:24981056
Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation. PMID:24979279
Osteoprotegerin expression in triple-negative breast cancer cells promotes metastasis. PMID:24976340
BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis. PMID:24974076
miR-409-3p/-5p promotes tumorigenesis, epithelial-to-mesenchymal transition, and bone metastasis of human prostate cancer. PMID:24963047
Constitutive androstane receptor ligands modulate the anti-tumor efficacy of paclitaxel in non-small cell lung cancer cells. PMID:24959746
WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies. PMID:24932569
Inhibitor of differentiation 4 (ID4) inactivation promotes de novo steroidogenesis and castration-resistant prostate cancer. PMID:24921661
MicroRNA Machinery Genes as Novel Biomarkers for Cancer. PMID:24904827
TCGA-assembler: open-source software for retrieving and processing TCGA data. PMID:24874569
MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival. PMID:24866769
Bioenergetic analysis of ovarian cancer cell lines: profiling of histological subtypes and identification of a mitochondria-defective cell line. PMID:24858344
Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors. PMID:24849047
Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer. PMID:24840646
Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. PMID:24810057
The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA. PMID:24798327
Oncogenic protein MTBP interacts with MYC to promote tumorigenesis. PMID:24786788
Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. PMID:24755468
Novel genetic targets in endometrial cancer. PMID:24750045
Class I HDACs Affect DNA Replication, Repair, and Chromatin Structure: Implications for Cancer Therapy. PMID:24730655
Combined PTEN Mutation and Protein Expression Associate with Overall and Disease-Free Survival of Glioblastoma Patients. PMID:24721394
SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker. PMID:24681808
Mining genome sequencing data to identify the genomic features linked to breast cancer histopathology. PMID:24672738
Prediction of individualized therapeutic vulnerabilities in cancer from genomic profiles. PMID:24665131
RNA editing in RHOQ promotes invasion potential in colorectal cancer. PMID:24663214
MCM10: one tool for all-Integrity, maintenance and damage control. PMID:24662891
Recurrent SMARCA4 mutations in small cell carcinoma of the ovary. PMID:24658004
PTEN function: the long and the short of it. PMID:24656806
Targeting TBP-Associated Factors in Ovarian Cancer. PMID:24653979
Lung tumourigenesis in a conditional Cul4A transgenic mouse model. PMID:24648314
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. PMID:24631838
Masking epistasis between MYC and TGF-β pathways in antiangiogenesis-mediated colon cancer suppression. PMID:24627270
CHD7 expression predicts survival outcomes in patients with resected pancreatic cancer. PMID:24626090
Driver mutations of cancer epigenomes. PMID:24622842
Nullifying the CDKN2AB locus promotes mutant K-ras lung tumorigenesis. PMID:24618618
Mdmx promotes genomic instability independent of p53 and Mdm2. PMID:24608433
Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells. PMID:24606123
Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance. PMID:24584939
Collection, integration and analysis of cancer genomic profiles: from data to insight. PMID:24584084
Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma. PMID:24578576
DDB2 suppresses tumorigenicity by limiting the cancer stem cell population in ovarian cancer. PMID:24574518
Estrogen signaling crosstalk: Implications for endocrine resistance in ovarian cancer. PMID:24565562
ARID1B is a specific vulnerability in ARID1A-mutant cancers. PMID:24562383
A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer. PMID:24551133
SYK allelic loss and the role of Syk-regulated genes in breast cancer survival. PMID:24523870
NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels. PMID:24521615
The Mdm network and its regulation of p53 activities: a rheostat of cancer risk. PMID:24488925
Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes. PMID:24469035
Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells. PMID:24465609
The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity. PMID:24393003
Turning off AKT: PHLPP as a drug target. PMID:24392697
MAP3K1: Genomic Alterations in Cancer and Function in Promoting Cell Survival or Apoptosis. PMID:24386504
A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis. PMID:24368541
Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers. PMID:24366882
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation. PMID:24351291
Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential. PMID:24349617
An emerging role of PARK2 in cancer. PMID:24297497
Characterizing the heterogeneity of triple-negative breast cancers using microdissected normal ductal epithelium and RNA-sequencing. PMID:24292813
Tracking progesterone receptor-mediated actions in breast cancer. PMID:24291072
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity. PMID:24240700
Γ-secretase components as predictors of breast cancer outcome. PMID:24223915
DriverDB: an exome sequencing database for cancer driver gene identification. PMID:24214964
Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7. PMID:24194518
The molecular balancing act of p16(INK4a) in cancer and aging. PMID:24136988
Using functional signature ontology (FUSION) to identify mechanisms of action for natural products. PMID:24129700
Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes. PMID:24114677
In vitro three-dimensional modeling of fallopian tube secretory epithelial cells. PMID:24070420
Low-copy piggyBac transposon mutagenesis in mice identifies genes driving melanoma. PMID:24003131
Integrin α3β1 can function to promote spontaneous metastasis and lung colonization of invasive breast carcinoma. PMID:24002891
Functional DNA quantification guides accurate next-generation sequencing mutation detection in formalin-fixed, paraffin-embedded tumor biopsies. PMID:24001039
Clinical Significance of HER-2 Splice Variants in Breast Cancer Progression and Drug Resistance. PMID:23935627
Expression of Tra2 β in Cancer Cells as a Potential Contributory Factor to Neoplasia and Metastasis. PMID:23935626
Intrinsic disorder in PTEN and its interactome confers structural plasticity and functional versatility. PMID:23783762
The mutational landscape of adenoid cystic carcinoma. PMID:23685749
http://dx.doi.org/10.1126/scisignal.2004088

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version: FAIRsharing.org: cBioPortal; cBioPortal for Cancer Genomics; DOI: https://doi.org/10.25504/FAIRsharing.6L6MjA; Last edited: Jan. 9, 2019, 3:06 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

copy number variation
metasource: Fairsharing.org
version: FAIRsharing.org: cBioPortal; cBioPortal for Cancer Genomics; DOI: https://doi.org/10.25504/FAIRsharing.6L6MjA; Last edited: Jan. 9, 2019, 3:06 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

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UCSC Cancer Genomics Browser

Cancer Genomics Hub

German Centre for Cancer Registry Data

The Database of Human DNA Methylation and Cancer

The Cancer Genome Atlas

Network of Cancer Genes

CanGEM

COLT-Cancer

intOGen

BCCTBbp

Progenetix - genomic copy number aberrations in cancer

National Cancer Institute's Genomic Data Commons

Cancer Registration Data

GENOMICS ENGLAND 100K PHE LINKED DATA

Cancer RNA-Seq Nexus

Candidate Cancer Gene Database

Cancer3D

CTDatabase

IARC TP53 Database

CMPD