Candidate Cancer Gene Database
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Candidate Cancer Gene Database
metasource: Fairsharing.org
version: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
CCGD
metasource: Fairsharing.org
version: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Names
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Candidate Cancer Gene Database
metasource: Fairsharing.orgversion: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
CCGD
metasource: Fairsharing.orgversion: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Names
More detailed information about this field from each metasource.
Candidate Cancer Gene Database
metasource: Fairsharing.orgversion: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
CCGD
metasource: Fairsharing.orgversion: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
The Candidate Cancer Gene Database (CCGD) was developed to disseminate the results of transposon-based forward genetic screens in mice that identify candidate cancer genes. The purpose of the database is to allow cancer researchers to quickly determine whether or not a gene, or list of genes, has been identified as a potential cancer driver in a forward genetic screen in mice.
Description
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The Candidate Cancer Gene Database (CCGD) was developed to disseminate the results of transposon-based forward genetic screens in mice that identify candidate cancer genes. The purpose of the database is to allow cancer researchers to quickly determine whether or not a gene, or list of genes, has been identified as a potential cancer driver in a forward genetic screen in mice.
metasource: Fairsharing.orgversion: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Identification of cancer driver genes is crucial to advancement of cancer therapeutics. The search for causative cancer driver genes in the human genome is complicated by the presence of passenger mutations which appear in overwhelming numbers, hiding low-penetrance cancer drivers. We have developed a method of identifying low-penetrance drivers by performing forward genetic screens in mice using DNA transposons as mutagens. Molecular analysis of the tumors arising in these mice allows for identification of transposon common insertion sites (CISs), where the frequency of transposon insertion is greater than expected by chance. Genes disrupted by the transposon insertions in these CISs are identified as candidate cancer driver genes. Our lab, along with many other labs, have used this method to identify thousands of candidate cancer driver genes. Unfortunately, the findings are scattered across dozens of publications using different mouse genome builds and strength metrics. We developed the Candidate Cancer Gene Database (CCGD, http://ccgd-starrlab.oit.umn.edu/) to improve access to these findings and facilitate meta-analyses. The CCGD is a manually curated database of candidate driver genes based on transposon CISs from all published, transposon-based forward genetic screens in mice. Users can quickly locate information on a gene of interest or generate a list of driver genes associated with a particular tumor type. The CCGD accepts queries by study and cancer type as well as by human, mouse, rat, fly, zebrafish, or yeast gene symbol or gene ID. The database supports export into a comma-separated file or a BED formatted file. Gene detail pages provide many links to external resources such as databases and genome browsers. To reduce curation burden, we automated many tasks involving processing of downloads from NCBI Gene, NCBI HomoloGene, Sanger CGC, and Sanger COSMIC. As the CCGD incorporates additional studies, it will facilitate identification of pathway and gene mutations specific to subsets of cancer. To demonstrate this potential, we performed a modified gene set enrichment analysis (GSEA) using KEGG pathwa
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Webpage:
http://ccgd-starrlab.oit.umn.edu/Webpage
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http://ccgd-starrlab.oit.umn.edu/
metasource: Fairsharing.orgversion: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications:
Publications
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The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice
PMID: 25190456
metasource: Fairsharing.org
version: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
http://dx.doi.org/10.1093/nar/gku770
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
More detailed information about this field from each metasource.
The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice
PMID: 25190456
metasource: Fairsharing.org
version: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
http://dx.doi.org/10.1093/nar/gku770
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice
PubMed citations: 57.
57 articles citing: The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice
Identifying Lethal Dependencies with HUGE Predictive Power. PMID:35805023
Isolation of a Human Betaretrovirus from Patients with Primary Biliary Cholangitis. PMID:35632628
Evaluation of cfDNA as an early detection assay for dense tissue breast cancer. PMID:35589867
Mutational characteristics of young and elderly gastric cancer: a comparative study. PMID:35284122
Stage-differentiated ensemble modeling of DNA methylation landscapes uncovers salient biomarkers and prognostic signatures in colorectal cancer progression. PMID:35202405
Discovering the key genes and important DNA methylation regions in breast cancer. PMID:35063044
Somatic Mutational Profile of High-Grade Serous Ovarian Carcinoma and Triple-Negative Breast Carcinoma in Young and Elderly Patients: Similarities and Divergences. PMID:34944094
Prognostic biomarkers for predicting papillary thyroid carcinoma patients at high risk using nine genes of apoptotic pathway. PMID:34767591
Interpretation of cancer mutations using a multiscale map of protein systems. PMID:34591613
Cancer LncRNA Census 2 (CLC2): an enhanced resource reveals clinical features of cancer lncRNAs. PMID:34316704
Framing the potential of public frameshift peptides as immunotherapy targets in colon cancer. PMID:34181673
Prognostic Biomarker-Based Identification of Drugs for Managing the Treatment of Endometrial Cancer. PMID:34155607
Integrative Data Analytic Framework to Enhance Cancer Precision Medicine. PMID:33796878
Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis. PMID:33783919
Use of signals of positive and negative selection to distinguish cancer genes and passenger genes. PMID:33427197
Discovering novel driver mutations from pan-cancer analysis of mutational and gene expression profiles. PMID:33232371
DORGE: Discovery of Oncogenes and tumoR suppressor genes using Genetic and Epigenetic features. PMID:33177077
Somatic mutation profiling in BRCA-negative breast and ovarian cancer patients by multigene panel sequencing. PMID:33042626
In vivo functional screening for systems-level integrative cancer genomics. PMID:32636489
Identification of Pan-Cancer Prognostic Biomarkers Through Integration of Multi-Omics Data. PMID:32300588
Biosystem Analysis of the Hypoxia Inducible Domain Family Member 2A: Implications in Cancer Biology. PMID:32085461
Co-occurrence and Mutual Exclusivity Analysis of DNA Methylation Reveals Distinct Subtypes in Multiple Cancers. PMID:32064261
Transposon Insertion Mutagenesis in Mice for Modeling Human Cancers: Critical Insights Gained and New Opportunities. PMID:32050713
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. PMID:32024996
Discovering master regulators in hepatocellular carcinoma: one novel MR, SEC14L2 inhibits cancer cells. PMID:31851620
Role of ion channels in gastrointestinal cancer. PMID:31636470
Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain. PMID:31523185
Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics. PMID:31338332
Quantifying gene selection in cancer through protein functional alteration bias. PMID:31334812
PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness. PMID:31279780
A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model. PMID:31061415
TranscriptAchilles: a genome-wide platform to predict isoform biomarkers of gene essentiality in cancer. PMID:30942869
Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice. PMID:30940846
Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene. PMID:30333512
Somatic mutations in early onset luminal breast cancer. PMID:29854292
Advances in functional genetic screening with transposons and CRISPR/Cas9 to illuminate cancer biology. PMID:29587177
Epigenetic restriction of Hippo signaling by MORC2 underlies stemness of hepatocellular carcinoma cells. PMID:29555977
Integrated analysis of microarray data to identify the genes critical for the rupture of intracranial aneurysm. PMID:29552131
Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells. PMID:29301589
SBCDDB: Sleeping Beauty Cancer Driver Database for gene discovery in mouse models of human cancers. PMID:29059366
Mutation-profile-based methods for understanding selection forces in cancer somatic mutations: a comparative analysis. PMID:28938601
Driver genes in non-small cell lung cancer: Characteristics, detection methods, and targeted therapies. PMID:28915704
Cell signalling pathway regulation by RanBPM: molecular insights and disease implications. PMID:28659384
Estimating genome-wide regulatory activity from multi-omics data sets using mathematical optimization. PMID:28347313
Germline large genomic alterations on 7q in patients with multiple primary cancers. PMID:28139749
Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice. PMID:28079877
Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma. PMID:27966608
Challenges in identifying cancer genes by analysis of exome sequencing data. PMID:27417679
Deep Genetic Connection Between Cancer and Developmental Disorders. PMID:27363847
dbCPG: A web resource for cancer predisposition genes. PMID:27192119
Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen. PMID:27038937
Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia. PMID:26500062
The mini-driver model of polygenic cancer evolution. PMID:26456849
Personalized targeted therapy for esophageal squamous cell carcinoma. PMID:26167067
Inference of transcriptional regulation in cancers. PMID:26056275
The 2015 Nucleic Acids Research Database Issue and molecular biology database collection. PMID:25593347
Sequencing methods and datasets to improve functional interpretation of sleeping beauty mutagenesis screens. PMID:25526783 - http://dx.doi.org/10.1093/nar/gku770
Tags:
Tags
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cancer
metasource: Fairsharing.org
version: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
gene
metasource: Fairsharing.org
version: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
transposable element
metasource: Fairsharing.org
version: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
human genes and diseases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
cancer gene databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Tags
More detailed information about this field from each metasource.
cancer
metasource: Fairsharing.orgversion: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
gene
metasource: Fairsharing.orgversion: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
transposable element
metasource: Fairsharing.orgversion: FAIRsharing.org: CCGD; Candidate Cancer Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.8njqwk; Last edited: Dec. 19, 2019, 4:02 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
human genes and diseases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
cancer gene databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
cancer gene transposable element human genes and diseases cancer-related genes
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