Telomerase Database
Names
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Telomerase Database
metasource: Fairsharing.org
version: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Telomerase database
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Names
More detailed information about this field from each metasource.
Telomerase Database
metasource: Fairsharing.orgversion: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Telomerase database
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Other names: Telomerase database
Names
More detailed information about this field from each metasource.
Telomerase Database
metasource: Fairsharing.orgversion: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Telomerase database
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
The Telomerase Database is a Web-based tool for the study of structure, function, and evolution of the telomerase ribonucleoprotein. The objective of this database is to serve the research community by providing a comprehensive compilation of information known about telomerase enzyme and its substrate, telomeres.
Description
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The Telomerase Database is a Web-based tool for the study of structure, function, and evolution of the telomerase ribonucleoprotein. The objective of this database is to serve the research community by providing a comprehensive compilation of information known about telomerase enzyme and its substrate, telomeres.
metasource: Fairsharing.orgversion: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Sequences and structures of the RNA and protein subunits of telomerase, mutations of telomerase components
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Webpage:
http://telomerase.asu.eduWebpage
More detailed information about this field from each metasource.
http://telomerase.asu.edu
metasource: Fairsharing.orgversion: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
http://telomerase.asu.edu/
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Publications:
Publications
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The telomerase database
PMID: 18073191
metasource: Fairsharing.org
version: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
Publications
More detailed information about this field from each metasource.
The telomerase database
PMID: 18073191
metasource: Fairsharing.org
version: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
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The telomerase database
PubMed citations: 117.
117 articles citing: The telomerase database
A novel cause of DKC1-related bone marrow failure: Partial deletion of the 3' untranslated region. PMID:35845273
Structure of active human telomerase with telomere shelterin protein TPP1. PMID:35418675
Structural basis of human telomerase recruitment by TPP1-POT1. PMID:35201900
POLIE suppresses telomerase-mediated telomere G-strand extension and helps ensure proper telomere C-strand synthesis in trypanosomes. PMID:35061898
TAR30, a homolog of the canonical plant TTTAGGG telomeric repeat, is enriched in the proximal chromosome regions of peanut (Arachis hypogaea L.). PMID:35043294
Why sequence all eukaryotes? PMID:35042801
Telomeric-Like Repeats Flanked by Sequences Retrotranscribed from the Telomerase RNA Inserted at DNA Double-Strand Break Sites during Vertebrate Genome Evolution. PMID:34681704
Regulation of Antigenic Variation by Trypanosoma brucei Telomere Proteins Depends on Their Unique DNA Binding Activities. PMID:34451431
Somatic reversion impacts myelodysplastic syndromes and acute myeloid leukemia evolution in the short telomere disorders. PMID:34343137
Keeping Balance Between Genetic Stability and Plasticity at the Telomere and Subtelomere of Trypanosoma brucei. PMID:34291053
Potential of Telomerase in Age-Related Macular Degeneration-Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α. PMID:34281248
GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A: a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres. PMID:34214172
The clinical and functional effects of TERT variants in myelodysplastic syndrome. PMID:34019641
Structures of telomerase at several steps of telomere repeat synthesis. PMID:33981033
Structure of human telomerase holoenzyme with bound telomeric DNA. PMID:33883742
Could We Address the Interplay Between CD133, Wnt/β-Catenin, and TERT Signaling Pathways as a Potential Target for Glioblastoma Therapy? PMID:33869033
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. PMID:33564154
Step-by-Step Evolution of Telomeres: Lessons from Yeasts. PMID:33537752
SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization. PMID:33526451
Molecular mechanisms of telomere biology disorders. PMID:33482595
Identification and characterization of novel ACD variants: modulation of TPP1 protein level offsets the impact of germline loss-of-function variants on telomere length. PMID:33446513
A structurally conserved human and Tetrahymena telomerase catalytic core. PMID:33229538
Telomerase RNA processing: Implications for human health and disease. PMID:32875693
Genetic Underpinnings of Host Manipulation by Ophiocordyceps as Revealed by Comparative Transcriptomics. PMID:32354705
A chromosome-scale assembly of the smallest Dothideomycete genome reveals a unique genome compaction mechanism in filamentous fungi. PMID:32326892
XPO5 promotes primary miRNA processing independently of RanGTP. PMID:32296071
Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions. PMID:32102938
Cancer spectrum and outcomes in the Mendelian short telomere syndromes. PMID:32076714
Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations. PMID:32033110
RNAconTest: comparing tools for noncoding RNA multiple sequence alignment based on structural consistency. PMID:32005745
A Nearly Complete Genome of Ciona intestinalis Type A (C. robusta) Reveals the Contribution of Inversion to Chromosomal Evolution in the Genus Ciona. PMID:31621849
Structural Biology of Telomerase. PMID:31451513
Pediatric Cancer Variant Pathogenicity Information Exchange (PeCanPIE): a cloud-based platform for curating and classifying germline variants. PMID:31439692
Long telomeres and cancer risk: the price of cellular immortality. PMID:31380804
Loss of Ku's DNA end binding activity affects telomere length via destabilizing telomere-bound Est1 rather than altering TLC1 homeostasis. PMID:31337791
How to benchmark RNA secondary structure prediction accuracy. PMID:30951834
N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation. PMID:30931479
Chromosome rearrangements shape the diversification of secondary metabolism in the cyclosporin producing fungus Tolypocladium inflatum. PMID:30732559
The H/ACA complex disrupts triplex in hTR precursor to permit processing by RRP6 and PARN. PMID:30575725
TOE1 acts as a 3' exonuclease for telomerase RNA and regulates telomere maintenance. PMID:30371886
Whole-Genome Resequencing and Pan-Transcriptome Reconstruction Highlight the Impact of Genomic Structural Variation on Secondary Metabolite Gene Clusters in the Grapevine Esca Pathogen Phaeoacremonium minimum. PMID:30150972
TERribly Difficult: Searching for Telomerase RNAs in Saccharomycetes. PMID:30049970
Mechanisms of template handling and pseudoknot folding in human telomerase and their manipulation to expand the sequence repertoire of processive repeat synthesis. PMID:29986069
An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1. PMID:29804836
TelNet - a database for human and yeast genes involved in telomere maintenance. PMID:29776332
Structure of Telomerase with Telomeric DNA. PMID:29775593
Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers. PMID:29641532
Distinct telomere length and molecular signatures in seminoma and non-seminoma of testicular germ cell tumor. PMID:29579225
Characterization and visualization of RNA secondary structure Boltzmann ensemble via information theory. PMID:29506466
Direct observation of nucleic acid binding dynamics by the telomerase essential N-terminal domain. PMID:29474579
Telomeres and genomic evolution. PMID:29335376
Structural biology of telomerase and its interaction at telomeres. PMID:28732250
Telomeres and telomerase in prostate cancer development and therapy. PMID:28675175
DNA-binding determinants and cellular thresholds for human telomerase repeat addition processivity. PMID:28495680
Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs): An experimental and in silico study. PMID:28392905
Progress in Human and Tetrahymena Telomerase Structure Determination. PMID:28301767
Telomerase Mechanism of Telomere Synthesis. PMID:28141967
Single-molecule FRET-Rosetta reveals RNA structural rearrangements during human telomerase catalysis. PMID:28096444
Telomerase Regulation from Beginning to the End. PMID:27649246
Condition-dependent co-regulation of genomic clusters of virulence factors in the grapevine trunk pathogen Neofusicoccum parvum. PMID:27608421
A Whole-Genome Analysis Framework for Effective Identification of Pathogenic Regulatory Variants in Mendelian Disease. PMID:27569544
Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human. PMID:27531956
Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell. PMID:27446102
The functional requirement of two structural domains within telomerase RNA emerged early in eukaryotes. PMID:27378779
Evolutionary perspectives of telomerase RNA structure and function. PMID:27359343
G-quadruplex DNA structures can interfere with uracil glycosylase activity in vitro. PMID:26671821
Structure and function of echinoderm telomerase RNA. PMID:26598712
A DNA-hairpin model for repeat-addition processivity in telomere synthesis. PMID:26581517
Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes. PMID:26457608
The molecular genetics of the telomere biology disorders. PMID:26400640
Impaired telomerase activity hinders proliferation and in vitro transformation of Penaeus monodon lymphoid cells. PMID:26084784
Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients. PMID:25992652
Telomere DNA recognition in Saccharomycotina yeast: potential lessons for the co-evolution of ssDNA and dsDNA-binding proteins and their target sites. PMID:25983743
Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder. PMID:25940403
TeloPIN: a database of telomeric proteins interaction network in mammalian cells. PMID:25792605
A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. PMID:25684364
Combinatorial recognition of a complex telomere repeat sequence by the Candida parapsilosis Cdc13AB heterodimer. PMID:25662607
Prevalent and distinct spliceosomal 3'-end processing mechanisms for fungal telomerase RNA. PMID:25598218
Osteoarthritis and telomere shortening. PMID:25366419
Telomere-regulating genes and the telomere interactome in familial cancers. PMID:25244922
Sequence specificity of human telomerase. PMID:25056966
A self-regulating template in human telomerase. PMID:24982163
Structural basis for protein-RNA recognition in telomerase. PMID:24793650
Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex. PMID:24619002
Structure and sequence elements of the CR4/5 domain of medaka telomerase RNA important for telomerase function. PMID:24335084
RNA connectivity requirements between conserved elements in the core of the yeast telomerase RNP. PMID:24129512
Vitreous hemorrhage secondary to retinal vasculopathy in a patient with dyskeratosis congenita. PMID:24114504
Telomere reprogramming and maintenance in porcine iPS cells. PMID:24098638
Telomere phenotypes in females with heterozygous mutations in the dyskeratosis congenita 1 (DKC1) gene. PMID:23946118
In silico discrimination of nsSNPs in hTERT gene by means of local DNA sequence context and regularity. PMID:23716176
RNA recognition by the DNA end-binding Ku heterodimer. PMID:23610127
Identification of purple sea urchin telomerase RNA using a next-generation sequencing based approach. PMID:23584428
A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome. PMID:23538340
The common ancestral core of vertebrate and fungal telomerase RNAs. PMID:23093598
An enhanced H/ACA RNP assembly mechanism for human telomerase RNA. PMID:22527283
Dynamic evolution of telomeric sequences in the green algal order Chlamydomonadales. PMID:22247428
DNAtraffic--a new database for systems biology of DNA dynamics during the cell life. PMID:22110027
It all comes together at the ends: telomerase structure, function, and biogenesis. PMID:22093366
Databases and bioinformatics tools for the study of DNA repair. PMID:22091405
The accumulation and not the specific activity of telomerase ribonucleoprotein determines telomere maintenance deficiency in X-linked dyskeratosis congenita. PMID:22058290
Molecular analysis of T-DNA insertion mutants identified putative regulatory elements in the AtTERT gene. PMID:21865176
Architecture of human telomerase RNA. PMID:21844345
Dyskeratosis congenita as a disorder of telomere maintenance. PMID:21745483
Mutational patterns in RNA secondary structure evolution examined in three RNA families. PMID:21698102
Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step. PMID:21606328
Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation. PMID:21514196
Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. PMID:21483807
Structurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNA. PMID:20966348
The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion. PMID:20670897
Telomere biology in Metazoa. PMID:20655915
Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNA. PMID:20554853
Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. PMID:20351177
A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity. PMID:20044353
Transcriptome Analysis of ESTs from a Chaetognath Reveals a Deep-Branching Clade of Retrovirus-Like Retrotransposons. PMID:19440464
Dyskeratosis congenita, stem cells and telomeres. PMID:19419704
Advances in the understanding of dyskeratosis congenita. PMID:19208095
Solution structure and dynamics of the wild-type pseudoknot of human telomerase RNA. PMID:18950640
Tags:
Tags
More detailed information about this field from each metasource.
deoxyribonucleic acid
metasource: Fairsharing.org
version: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
disease
metasource: Fairsharing.org
version: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
enzyme
metasource: Fairsharing.org
version: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
protein
metasource: Fairsharing.org
version: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
ribonucleic acid
metasource: Fairsharing.org
version: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
small molecule
metasource: Fairsharing.org
version: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
structure
metasource: Fairsharing.org
version: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
nucleotide sequence databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
transcriptional regulator sites and transcription factors
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
protein sequence databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
databases of individual protein families
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Tags
More detailed information about this field from each metasource.
deoxyribonucleic acid
metasource: Fairsharing.orgversion: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
disease
metasource: Fairsharing.orgversion: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
enzyme
metasource: Fairsharing.orgversion: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
protein
metasource: Fairsharing.orgversion: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
ribonucleic acid
metasource: Fairsharing.orgversion: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
small molecule
metasource: Fairsharing.orgversion: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
structure
metasource: Fairsharing.orgversion: FAIRsharing.org: Telomerase Database; Telomerase Database; DOI: https://doi.org/10.25504/FAIRsharing.fqcrpt; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
nucleotide sequence databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
transcriptional regulator sites and transcription factors
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
protein sequence databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
databases of individual protein families
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
dna disease enzyme protein rna small molecule structure nucleic acid sequence transcription protein sequence protein family
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