A novel cause of DKC1-related bone marrow failure: Partial deletion of the 3' untranslated region.
PMID:35845273
Structure of active human telomerase with telomere shelterin protein TPP1.
PMID:35418675
Structural basis of human telomerase recruitment by TPP1-POT1.
PMID:35201900
POLIE suppresses telomerase-mediated telomere G-strand extension and helps ensure proper telomere C-strand synthesis in trypanosomes.
PMID:35061898
TAR30, a homolog of the canonical plant TTTAGGG telomeric repeat, is enriched in the proximal chromosome regions of peanut (Arachis hypogaea L.).
PMID:35043294
Why sequence all eukaryotes?
PMID:35042801
Telomeric-Like Repeats Flanked by Sequences Retrotranscribed from the Telomerase RNA Inserted at DNA Double-Strand Break Sites during Vertebrate Genome Evolution.
PMID:34681704
Regulation of Antigenic Variation by Trypanosoma brucei Telomere Proteins Depends on Their Unique DNA Binding Activities.
PMID:34451431
Somatic reversion impacts myelodysplastic syndromes and acute myeloid leukemia evolution in the short telomere disorders.
PMID:34343137
Keeping Balance Between Genetic Stability and Plasticity at the Telomere and Subtelomere of Trypanosoma brucei.
PMID:34291053
Potential of Telomerase in Age-Related Macular Degeneration-Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α.
PMID:34281248
GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A: a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres.
PMID:34214172
The clinical and functional effects of TERT variants in myelodysplastic syndrome.
PMID:34019641
Structures of telomerase at several steps of telomere repeat synthesis.
PMID:33981033
Structure of human telomerase holoenzyme with bound telomeric DNA.
PMID:33883742
Could We Address the Interplay Between CD133, Wnt/β-Catenin, and TERT Signaling Pathways as a Potential Target for Glioblastoma Therapy?
PMID:33869033
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.
PMID:33564154
Step-by-Step Evolution of Telomeres: Lessons from Yeasts.
PMID:33537752
SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization.
PMID:33526451
Molecular mechanisms of telomere biology disorders.
PMID:33482595
Identification and characterization of novel ACD variants: modulation of TPP1 protein level offsets the impact of germline loss-of-function variants on telomere length.
PMID:33446513
A structurally conserved human and Tetrahymena telomerase catalytic core.
PMID:33229538
Telomerase RNA processing: Implications for human health and disease.
PMID:32875693
Genetic Underpinnings of Host Manipulation by Ophiocordyceps as Revealed by Comparative Transcriptomics.
PMID:32354705
A chromosome-scale assembly of the smallest Dothideomycete genome reveals a unique genome compaction mechanism in filamentous fungi.
PMID:32326892
XPO5 promotes primary miRNA processing independently of RanGTP.
PMID:32296071
Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions.
PMID:32102938
Cancer spectrum and outcomes in the Mendelian short telomere syndromes.
PMID:32076714
Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations.
PMID:32033110
RNAconTest: comparing tools for noncoding RNA multiple sequence alignment based on structural consistency.
PMID:32005745
A Nearly Complete Genome of Ciona intestinalis Type A (C. robusta) Reveals the Contribution of Inversion to Chromosomal Evolution in the Genus Ciona.
PMID:31621849
Structural Biology of Telomerase.
PMID:31451513
Pediatric Cancer Variant Pathogenicity Information Exchange (PeCanPIE): a cloud-based platform for curating and classifying germline variants.
PMID:31439692
Long telomeres and cancer risk: the price of cellular immortality.
PMID:31380804
Loss of Ku's DNA end binding activity affects telomere length via destabilizing telomere-bound Est1 rather than altering TLC1 homeostasis.
PMID:31337791
How to benchmark RNA secondary structure prediction accuracy.
PMID:30951834
N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation.
PMID:30931479
Chromosome rearrangements shape the diversification of secondary metabolism in the cyclosporin producing fungus Tolypocladium inflatum.
PMID:30732559
The H/ACA complex disrupts triplex in hTR precursor to permit processing by RRP6 and PARN.
PMID:30575725
TOE1 acts as a 3' exonuclease for telomerase RNA and regulates telomere maintenance.
PMID:30371886
Whole-Genome Resequencing and Pan-Transcriptome Reconstruction Highlight the Impact of Genomic Structural Variation on Secondary Metabolite Gene Clusters in the Grapevine Esca Pathogen Phaeoacremonium minimum.
PMID:30150972
TERribly Difficult: Searching for Telomerase RNAs in Saccharomycetes.
PMID:30049970
Mechanisms of template handling and pseudoknot folding in human telomerase and their manipulation to expand the sequence repertoire of processive repeat synthesis.
PMID:29986069
An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1.
PMID:29804836
TelNet - a database for human and yeast genes involved in telomere maintenance.
PMID:29776332
Structure of Telomerase with Telomeric DNA.
PMID:29775593
Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers.
PMID:29641532
Distinct telomere length and molecular signatures in seminoma and non-seminoma of testicular germ cell tumor.
PMID:29579225
Characterization and visualization of RNA secondary structure Boltzmann ensemble via information theory.
PMID:29506466
Direct observation of nucleic acid binding dynamics by the telomerase essential N-terminal domain.
PMID:29474579
Telomeres and genomic evolution.
PMID:29335376
Structural biology of telomerase and its interaction at telomeres.
PMID:28732250
Telomeres and telomerase in prostate cancer development and therapy.
PMID:28675175
DNA-binding determinants and cellular thresholds for human telomerase repeat addition processivity.
PMID:28495680
Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs): An experimental and in silico study.
PMID:28392905
Progress in Human and Tetrahymena Telomerase Structure Determination.
PMID:28301767
Telomerase Mechanism of Telomere Synthesis.
PMID:28141967
Single-molecule FRET-Rosetta reveals RNA structural rearrangements during human telomerase catalysis.
PMID:28096444
Telomerase Regulation from Beginning to the End.
PMID:27649246
Condition-dependent co-regulation of genomic clusters of virulence factors in the grapevine trunk pathogen Neofusicoccum parvum.
PMID:27608421
A Whole-Genome Analysis Framework for Effective Identification of Pathogenic Regulatory Variants in Mendelian Disease.
PMID:27569544
Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human.
PMID:27531956
Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell.
PMID:27446102
The functional requirement of two structural domains within telomerase RNA emerged early in eukaryotes.
PMID:27378779
Evolutionary perspectives of telomerase RNA structure and function.
PMID:27359343
G-quadruplex DNA structures can interfere with uracil glycosylase activity in vitro.
PMID:26671821
Structure and function of echinoderm telomerase RNA.
PMID:26598712
A DNA-hairpin model for repeat-addition processivity in telomere synthesis.
PMID:26581517
Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes.
PMID:26457608
The molecular genetics of the telomere biology disorders.
PMID:26400640
Impaired telomerase activity hinders proliferation and in vitro transformation of Penaeus monodon lymphoid cells.
PMID:26084784
Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients.
PMID:25992652
Telomere DNA recognition in Saccharomycotina yeast: potential lessons for the co-evolution of ssDNA and dsDNA-binding proteins and their target sites.
PMID:25983743
Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder.
PMID:25940403
TeloPIN: a database of telomeric proteins interaction network in mammalian cells.
PMID:25792605
A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.
PMID:25684364
Combinatorial recognition of a complex telomere repeat sequence by the Candida parapsilosis Cdc13AB heterodimer.
PMID:25662607
Prevalent and distinct spliceosomal 3'-end processing mechanisms for fungal telomerase RNA.
PMID:25598218
Osteoarthritis and telomere shortening.
PMID:25366419
Telomere-regulating genes and the telomere interactome in familial cancers.
PMID:25244922
Sequence specificity of human telomerase.
PMID:25056966
A self-regulating template in human telomerase.
PMID:24982163
Structural basis for protein-RNA recognition in telomerase.
PMID:24793650
Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex.
PMID:24619002
Structure and sequence elements of the CR4/5 domain of medaka telomerase RNA important for telomerase function.
PMID:24335084
RNA connectivity requirements between conserved elements in the core of the yeast telomerase RNP.
PMID:24129512
Vitreous hemorrhage secondary to retinal vasculopathy in a patient with dyskeratosis congenita.
PMID:24114504
Telomere reprogramming and maintenance in porcine iPS cells.
PMID:24098638
Telomere phenotypes in females with heterozygous mutations in the dyskeratosis congenita 1 (DKC1) gene.
PMID:23946118
In silico discrimination of nsSNPs in hTERT gene by means of local DNA sequence context and regularity.
PMID:23716176
RNA recognition by the DNA end-binding Ku heterodimer.
PMID:23610127
Identification of purple sea urchin telomerase RNA using a next-generation sequencing based approach.
PMID:23584428
A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome.
PMID:23538340
The common ancestral core of vertebrate and fungal telomerase RNAs.
PMID:23093598
An enhanced H/ACA RNP assembly mechanism for human telomerase RNA.
PMID:22527283
Dynamic evolution of telomeric sequences in the green algal order Chlamydomonadales.
PMID:22247428
DNAtraffic--a new database for systems biology of DNA dynamics during the cell life.
PMID:22110027
It all comes together at the ends: telomerase structure, function, and biogenesis.
PMID:22093366
Databases and bioinformatics tools for the study of DNA repair.
PMID:22091405
The accumulation and not the specific activity of telomerase ribonucleoprotein determines telomere maintenance deficiency in X-linked dyskeratosis congenita.
PMID:22058290
Molecular analysis of T-DNA insertion mutants identified putative regulatory elements in the AtTERT gene.
PMID:21865176
Architecture of human telomerase RNA.
PMID:21844345
Dyskeratosis congenita as a disorder of telomere maintenance.
PMID:21745483
Mutational patterns in RNA secondary structure evolution examined in three RNA families.
PMID:21698102
Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step.
PMID:21606328
Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation.
PMID:21514196
Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis.
PMID:21483807
Structurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNA.
PMID:20966348
The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion.
PMID:20670897
Telomere biology in Metazoa.
PMID:20655915
Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNA.
PMID:20554853
Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo.
PMID:20351177
A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity.
PMID:20044353
Transcriptome Analysis of ESTs from a Chaetognath Reveals a Deep-Branching Clade of Retrovirus-Like Retrotransposons.
PMID:19440464
Dyskeratosis congenita, stem cells and telomeres.
PMID:19419704
Advances in the understanding of dyskeratosis congenita.
PMID:19208095
Solution structure and dynamics of the wild-type pseudoknot of human telomerase RNA.
PMID:18950640