Genome editing technology is a fast-growing and rapidly advancing global bioscience field with applications in many biotechnology sectors. Genome editing is used to modify the nucleic acids of a genetic code, which can be composed of DNA or RNA, in a site-specific manner. Modifications can include insertion, deletion or alteration of nucleic acids. The technology operates by biochemical principles generally applicable to every kind of cell. Examples of genome editing technology applications with global significance include human cell-based therapeutics, agriculture, microbial based therapeutics, synthetic biology and biomanufacturing. While genome editing technology is being actively utilized, there is a need for international standardization in terms and definitions for this field, so as to enhance interpretation and communication of concepts, data and results. This document has been developed to provide a unified standard set of terms and definitions that serve the needs of biotechnology stakeholders and act as a reference for genome editing technology.