Integrated Interactions Database

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Integrated Interactions Database

metasource: Fairsharing.org
version: None

metasource: re3data.org
version: re3data.org: Integrated Interactions Database; editing status 2022-06-22; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R30X9H last accessed: 2022-11-04

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IID

metasource: Fairsharing.org
version: None

metasource: re3data.org
version: re3data.org: Integrated Interactions Database; editing status 2022-06-22; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R30X9H last accessed: 2022-11-04

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Other names: IID

The Integrated Interactions Database (IID) is a database of detected and predicted protein-protein interactions (PPIs) in a number of species. It stores networks that are specific to tissues, sub-cellular localizations, diseases, and druggable proteins.

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Publications

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IID 2018 update: context-specific physical protein-protein interactions in human, model organisms and domesticated species
PMID: 30407591

metasource: Fairsharing.org
version: None

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• IID 2018 update: context-specific physical protein-protein interactions in human, model organisms and domesticated species PubMed citations: 64.

  64 articles citing: IID 2018 update: context-specific physical protein-protein interactions in human, model organisms and domesticated species

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  The heterogeneous pharmacological medical biochemical network PharMeBINet. PMID:35821017

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  Impact of Human Genetic Variation on C-Reactive Protein Concentrations and Acute Appendicitis. PMID:35693796

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  IMEx Databases: Displaying Molecular Interactions into a Single, Standards-Compliant Dataset. PMID:35507258

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  Transcriptomic and Drug Discovery Analyses Reveal Natural Compounds Targeting the KDM4 Subfamily as Promising Adjuvant Treatments in Cancer. PMID:35480330

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  Systems-Level Analysis of Genetic Variants Reveals Functional and Spatiotemporal Context in Treatment-resistant Schizophrenia. PMID:35278208

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  JAK-STAT core cancer pathway: An integrative cancer interactome analysis. PMID:35229974

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  CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system. PMID:35156780

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  Correcting Differential Gene Expression Analysis for Cyto-Architectural Alterations in Substantia Nigra of Parkinson's Disease Patients Reveals Known and Potential Novel Disease-Associated Genes and Pathways. PMID:35053314

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  Potential Molecular Mechanisms and Remdesivir Treatment for Acute Respiratory Syndrome Corona Virus 2 Infection/COVID 19 Through RNA Sequencing and Bioinformatics Analysis. PMID:34992355

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  Improving Analysis and Annotation of Microarray Data with Protein Interactions. PMID:34902122

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  Estrogen Receptor 1 Inhibition of Wnt/β-Catenin Signaling Contributes to Sex Differences in Hepatocarcinogenesis. PMID:34881186

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  Therapeutic targeting of SPIB/SPI1-facilitated interplay of cancer cells and neutrophils inhibits aerobic glycolysis and cancer progression. PMID:34841706

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  Network medicine for disease module identification and drug repurposing with the NeDRex platform. PMID:34824199

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  A Network Biology Approach to Understanding the Tissue-Specific Roles of Non-Coding RNAs in Arthritis. PMID:34803912

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  The IntAct database: efficient access to fine-grained molecular interaction data. PMID:34761267

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  IID 2021: towards context-specific protein interaction analyses by increased coverage, enhanced annotation and enrichment analysis. PMID:34755877

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  MOSGA 2: Comparative genomics and validation tools. PMID:34712396

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  SARS-CoV-2-host proteome interactions for antiviral drug discovery. PMID:34709727

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  The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response. PMID:34645905

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  Getting to know each other: PPIMem, a novel approach for predicting transmembrane protein-protein complexes. PMID:34630938

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  Cross-Species and Human Inter-Tissue Network Analysis of Genes Implicated in Longevity and Aging Reveal Strong Support for Nutrient Sensing. PMID:34512728

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  Tau Protein Interaction Partners and Their Roles in Alzheimer's Disease and Other Tauopathies. PMID:34502116

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  Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context. PMID:34440098

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  Biomolecule and Bioentity Interaction Databases in Systems Biology: A Comprehensive Review. PMID:34439912

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  Mechanism-Centric Approaches for Biomarker Detection and Precision Therapeutics in Cancer. PMID:34408770

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  Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology. PMID:34270705

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  FINER: enhancing the prediction of tissue-specific functions of isoforms by refining isoform interaction networks. PMID:34169280

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  Model-based analysis uncovers mutations altering autophagy selectivity in human cancer. PMID:34059679

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  Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection. PMID:34031419

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  The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age. PMID:34027897

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  Predicting Protein-Protein Interactions Using Symmetric Logistic Matrix Factorization. PMID:33831302

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  The Relevance of Bioinformatics Applications in the Discovery of Vaccine Candidates and Potential Drugs for COVID-19 Treatment. PMID:33795932

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  Bioinformatics analyses of significant genes, related pathways, and candidate diagnostic biomarkers and molecular targets in SARS-CoV-2/COVID-19. PMID:33553808

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  Human pathways in animal models: possibilities and limitations. PMID:33524155

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  SECAT: Quantifying Protein Complex Dynamics across Cell States by Network-Centric Analysis of SEC-SWATH-MS Profiles. PMID:33333029

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  Protein Interaction Network Biology in Neuroscience. PMID:33314619

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  Rho-GTPase pathways may differentiate treatment response to TNF-alpha and IL-17A inhibitors in psoriatic arthritis. PMID:33303908

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  The conformational and mutational landscape of the ubiquitin-like marker for autophagosome formation in cancer. PMID:33302793

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  Towards a unified open access dataset of molecular interactions. PMID:33262342

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  Driving integrative structural modeling with serial capture affinity purification. PMID:33257578

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  The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets. PMID:33237311

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  PINA 3.0: mining cancer interactome. PMID:33231689

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  NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype. PMID:33170835

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  Individuating Possibly Repurposable Drugs and Drug Targets for COVID-19 Treatment Through Hypothesis-Driven Systems Medicine Using CoVex. PMID:33164550

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  Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research. PMID:33147627

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  Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19. PMID:33128875

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  Identification of Candidate Genes Associated with Charcot-Marie-Tooth Disease by Network and Pathway Analysis. PMID:33029488

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  A pan-cancer assessment of alterations of the kinase domain of ULK1, an upstream regulator of autophagy. PMID:32913252

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  Extracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection: A Proteomics Study. PMID:32900843

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  Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies. PMID:32780286

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  Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing. PMID:32665542

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  Data-driven network alignment. PMID:32614833

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  MIPPIE: the mouse integrated protein-protein interaction reference. PMID:32496562

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  Urinary proteomics links keratan sulfate degradation and lysosomal enzymes to early type 1 diabetes. PMID:32453760

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  Germline Mutation in MUS81 Resulting in Impaired Protein Stability is Associated with Familial Breast and Thyroid Cancer. PMID:32443704

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  Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition. PMID:32415080

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  Molecular networks in Network Medicine: Development and applications. PMID:32307915

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  Precision medicine - networks to the rescue. PMID:32199228

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  Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. PMID:31980649

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  Alterations of the interactome of Bcl-2 proteins in breast cancer at the transcriptional, mutational and structural level. PMID:31825969

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  pathDIP 4: an extended pathway annotations and enrichment analysis resource for human, model organisms and domesticated species. PMID:31733064

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  Biological Network Approaches and Applications in Rare Disease Studies. PMID:31614842

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  Protein-protein interactions of drug uptake transporters that are important for liver and kidney. PMID:31381872

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  Identification of key modules and hub genes for small-cell lung carcinoma and large-cell neuroendocrine lung carcinoma by weighted gene co-expression network analysis of clinical tissue-proteomes. PMID:31166966

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orthologous

metasource: Fairsharing.org
version: None

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protein

metasource: Fairsharing.org
version: None

metasource: re3data.org
version: re3data.org: Integrated Interactions Database; editing status 2022-06-22; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R30X9H last accessed: 2022-11-04

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protein interaction

metasource: Fairsharing.org
version: None

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fly

metasource: re3data.org
version: re3data.org: Integrated Interactions Database; editing status 2022-06-22; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R30X9H last accessed: 2022-11-04

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human

metasource: re3data.org
version: re3data.org: Integrated Interactions Database; editing status 2022-06-22; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R30X9H last accessed: 2022-11-04

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mouse

metasource: re3data.org
version: re3data.org: Integrated Interactions Database; editing status 2022-06-22; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R30X9H last accessed: 2022-11-04

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organisms

metasource: re3data.org
version: re3data.org: Integrated Interactions Database; editing status 2022-06-22; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R30X9H last accessed: 2022-11-04

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rat

metasource: re3data.org
version: re3data.org: Integrated Interactions Database; editing status 2022-06-22; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R30X9H last accessed: 2022-11-04

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worm

metasource: re3data.org
version: re3data.org: Integrated Interactions Database; editing status 2022-06-22; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R30X9H last accessed: 2022-11-04

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yeast

metasource: re3data.org
version: re3data.org: Integrated Interactions Database; editing status 2022-06-22; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R30X9H last accessed: 2022-11-04

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orthology protein protein interaction fly human mouse organisms rat worm yeast