I2D - Interologous Interaction Database

High-throughput experiments are being performed at an ever-increasing rate to systematically elucidate protein-protein interaction (PPI) networks for model organisms, while similar experiments for human networks have lagged far behind. The Online Predicted Human Interaction Database (OPHID) is a web-based database of predicted interactions between human proteins. It combines the literature-derived human PPIs from BIND, HPRD and MINT, with predictions made from Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and Mus musculus. The 23,889 predicted interactions currently listed in OPHID are evaluated using protein domains, gene co-expression and Gene Ontology terms. OPHID can be queried using single IDs or batch queries, and using multiple supported ID types. The results can be displayed as text, HTML, or visualized using our custom graph visualization program. In addition, the entire database is available for download in tab-delimited text or PSI-compliant XML format.




metabolic and signaling pathways protein-protein interactions

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