Compartmentalized Protein-Protein Interaction
Names
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Compartmentalized Protein-Protein Interaction
metasource: Fairsharing.org
version: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
ComPPI
metasource: Fairsharing.org
version: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Names
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Compartmentalized Protein-Protein Interaction
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
ComPPI
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Names
More detailed information about this field from each metasource.
Compartmentalized Protein-Protein Interaction
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
ComPPI
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
The compartmentalized protein-protein interaction database (ComPPI), provides qualitative information on the interactions, proteins and their localizations integrated from multiple databases for protein-protein interaction network analysis.
Description
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The compartmentalized protein-protein interaction database (ComPPI), provides qualitative information on the interactions, proteins and their localizations integrated from multiple databases for protein-protein interaction network analysis.
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
Protein-protein interaction networks are spatially and temporally merged from the results of various experimental and predicting methods (1). These often ignore localization data, which in turn deteriorates the data quality and its predictive potential. ComPPI is a cellular compartment-specific database of proteins and their interactions enabling an extensive, compartmentalized protein-protein interaction network analysis (URL: http://comppi.linkgroup.hu/). ComPPI enables the user to filter biologically unlikely interactions, where the two interacting proteins have no common subcellular localizations and to predict novel properties, such as compartment-specific biological functions. The overlap of the data among various databases can be very low (2), therefore the integration extended with manual curation protocols results in improved data quality. The compilation of 9 protein-protein interaction and 8 subcellular localization datasets (http://comppi.linkgroup.hu/help/input_databases) had 4 curation steps including a manually built, comprehensive hierarchical structure of cellular localization data localizing them to one or several of >1,600 Gene Ontology cellular component terms (3) assigning these proteins into distinct sub-cellular compartments (http://comppi.linkgroup.hu/help/subcell_locs). The proteome-wide dataset contains localizations for 5 main subcellular organelles (nucleus, mitochondrion, cytosol, secretory-pathway, membrane) and the extracellular compartment. The ComPPI database includes comprehensive and integrated data of four species (S. cerevisiae, C. elegans, D. melanogaster and H. sapiens) cataloguing 125,757 proteins, their 791,059 interactions and 195,815 major subcellular localizations in its current, 1.1 version (http://comppi.linkgroup.hu/help/statistics). ComPPI provides confidence scores for protein subcellular localizations and protein-protein interactions (http://comppi.linkgroup.hu/help/scores). ComPPI has user-friendly search options for individual proteins giving their subcellular localization, their interactions and the likelihood of their interactions considering the subcellular localization of their interacting partners (http://comppi.linkgroup.hu/protein_search). Download options of search results, whole-proteomes, organelle-specific interactomes, and subcellular localization data are available on its website (http://comppi.linkgroup.hu/downloads). Due to its novel features, ComPPI is an integrative, open source database useful for the analysis of experimental results in biochemistry and molecular biology, as well as for proteome-wide studies in bioinformatics and network science helping cellular biology, medicine and drug design.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Webpage:
http://comppi.linkgroup.hu/Webpage
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http://comppi.linkgroup.hu/
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://comppi.linkgroup.hu
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Licence:
Name: Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)Licence name
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Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
Licence URL
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https://creativecommons.org/licenses/by-sa/4.0/
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
Publications:
Publications
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http://dx.doi.org/in press (arXiv: http://arxiv.org/abs/1410.2494)
metasource: Fairsharing.org
version: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://dx.doi.org/10.1093/nar/gku1007
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
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http://dx.doi.org/in press (arXiv: http://arxiv.org/abs/1410.2494)
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://dx.doi.org/10.1093/nar/gku1007
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
- http://dx.doi.org/in press (arXiv: http://arxiv.org/abs/1410.2494)
- http://dx.doi.org/10.1093/nar/gku1007
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cellular component
metasource: Fairsharing.org
version: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
cellular localization
metasource: Fairsharing.org
version: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
confidence score
metasource: Fairsharing.org
version: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
interactome
metasource: Fairsharing.org
version: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
network model
metasource: Fairsharing.org
version: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
protein interaction
metasource: Fairsharing.org
version: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metabolic and signaling pathways
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
protein-protein interactions
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Tags
More detailed information about this field from each metasource.
cellular component
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
cellular localization
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
confidence score
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
interactome
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
network model
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
protein interaction
metasource: Fairsharing.orgversion: FAIRsharing.org: ComPPI; Compartmentalized Protein-Protein Interaction; DOI: https://doi.org/10.25504/FAIRsharing.rt38zh; Last edited: Jan. 8, 2019, 1:21 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metabolic and signaling pathways
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
protein-protein interactions
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
cellular component cellular localization confidence score interactome network model protein interaction metabolic and signaling pathways protein-protein interactions
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