Protein Protein Interaction Inhibition Database
Names
More detailed information about this field from each metasource.
Protein Protein Interaction Inhibition Database
metasource: Fairsharing.org
version: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
2P2Idb
metasource: Fairsharing.org
version: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Names
More detailed information about this field from each metasource.
Protein Protein Interaction Inhibition Database
metasource: Fairsharing.orgversion: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
2P2Idb
metasource: Fairsharing.orgversion: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Names
More detailed information about this field from each metasource.
Protein Protein Interaction Inhibition Database
metasource: Fairsharing.orgversion: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
2P2Idb
metasource: Fairsharing.orgversion: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
This source may no longer be available. No known URL could be resolved successfully.
2P2Idb is a hand-curated structural database dedicated to the modulation of protein-protein interactions (PPIs). It includes all interactions for which both the protein-protein and protein-modulator complexes have been structurally characterized by X-ray or NMR. The 2P2I database currently contains 14 protein-protein complexes, 16 free proteins, 56 protein-ligand complexes and 53 small molecule inhibitors. Only inhibitors found at the interface (orthosteric modulators) have been considered in this version of the database. The web server provides links to related sites of interest, binding affinity data, pre-calculated structural information about protein-protein interfaces and 3D interactive views through java applets.
Description
More detailed information about this field from each metasource.
2P2Idb is a hand-curated structural database dedicated to the modulation of protein-protein interactions (PPIs). It includes all interactions for which both the protein-protein and protein-modulator complexes have been structurally characterized by X-ray or NMR. The 2P2I database currently contains 14 protein-protein complexes, 16 free proteins, 56 protein-ligand complexes and 53 small molecule inhibitors. Only inhibitors found at the interface (orthosteric modulators) have been considered in this version of the database. The web server provides links to related sites of interest, binding affinity data, pre-calculated structural information about protein-protein interfaces and 3D interactive views through java applets.
metasource: Fairsharing.orgversion: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
2P2Idb is a hand-curated structural database dedicated to the modulation of protein-protein interactions (PPIs). It includes all interactions for which both the protein-protein and protein-modulator complexes have been structurally characterized by X-ray or NMR (1,2). The 2P2I database currently contains 14 protein-protein complexes, 16 free proteins, 56 protein-ligand complexes and 53 small molecule inhibitors. Only inhibitors found at the interface (orthosteric modulators) have been considered in this version of the database. The web server provides links to related sites of interest, binding affinity data, pre-calculated structural information about protein-protein interfaces and 3D interactive views through java applets.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Webpage:
http://2p2idb.cnrs-mrs.frWebpage
More detailed information about this field from each metasource.
http://2p2idb.cnrs-mrs.fr
metasource: Fairsharing.orgversion: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://2p2idb.cnrs-mrs.fr/
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Publications:
Publications
More detailed information about this field from each metasource.
2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions
PMID: 23203891
metasource: Fairsharing.org
version: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database
PMID: 20231898
metasource: Fairsharing.org
version: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://dx.doi.org/10.1093/nar/gks1002
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
More detailed information about this field from each metasource.
2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions
PMID: 23203891
metasource: Fairsharing.org
version: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database
PMID: 20231898
metasource: Fairsharing.org
version: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://dx.doi.org/10.1093/nar/gks1002
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions
PubMed citations: 59.
59 articles citing: 2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions
Probing GPCR Dimerization Using Peptides. PMID:35909575
Structure-based assessment and druggability classification of protein-protein interaction sites. PMID:35562538
Protein-protein interactions: Methods, databases, and applications in virus-host study. PMID:34909403
Divide et impera: An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication. PMID:34065234
Measuring the subcellular compartmentalization of viral infections by protein complementation assay. PMID:33402530
Docking-based identification of small-molecule binding sites at protein-protein interfaces. PMID:33250973
A complex between the Zika virion and the Fab of a broadly cross-reactive neutralizing monoclonal antibody revealed by cryo-EM and single particle analysis at 4.1 Å resolution. PMID:32647830
The design and development of covalent protein-protein interaction inhibitors for cancer treatment. PMID:32228680
Biophysical Techniques for Target Validation and Drug Discovery in Transcription-Targeted Therapy. PMID:32225120
Rules of Engagement: GPCRs and G Proteins. PMID:32219204
AlphaSpace 2.0: Representing Concave Biomolecular Surfaces Using β-Clusters. PMID:31995373
Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. PMID:31276567
Atypical activation of the G protein Gαq by the oncogenic mutation Q209P. PMID:30352874
In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL). PMID:30090063
Evolution of In Silico Strategies for Protein-Protein Interaction Drug Discovery. PMID:30082644
Inhibition of protein interactions: co-crystalized protein-protein interfaces are nearly as good as holo proteins in rigid-body ligand docking. PMID:30003468
Engineered protein scaffolds as leads for synthetic inhibitors of protein-protein interactions. PMID:29803113
Assessment of a Single Decoupling Alchemical Approach for the Calculation of the Absolute Binding Free Energies of Protein-Peptide Complexes. PMID:29568737
Heterodimer Binding Scaffolds Recognition via the Analysis of Kinetically Hot Residues. PMID:29547506
Development of Protein-Protein Interaction Inhibitors for the Treatment of Infectious Diseases. PMID:29459032
HawkRank: a new scoring function for protein-protein docking based on weighted energy terms. PMID:29282565
When theory meets experiment: the PD-1 challenge. PMID:29019005
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298). PMID:28853884
The Gαi-GIV binding interface is a druggable protein-protein interaction. PMID:28819150
Exploring the potential of a structural alphabet-based tool for mining multiple target conformations and target flexibility insight. PMID:28817602
Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin. PMID:28706685
Electrostatic interactions between the CTX phage minor coat protein and the bacterial host receptor TolA drive the pathogenic conversion of Vibrio cholerae. PMID:28642371
Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis. PMID:28617811
The IQGAP1 N-Terminus Forms Dimers, and the Dimer Interface Is Required for Binding F-Actin and Calcium-Bound Calmodulin. PMID:27798963
Peptiderive server: derive peptide inhibitors from protein-protein interactions. PMID:27141963
Small molecules, big targets: drug discovery faces the protein-protein interaction challenge. PMID:27050677
Structure-guided design of small-molecule therapeutics against RSV disease. PMID:27046051
Gene Prioritization by Integrated Analysis of Protein Structural and Network Topological Properties for the Protein-Protein Interaction Network of Neurological Disorders. PMID:27034906
2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions. PMID:26980515
Local Geometry and Evolutionary Conservation of Protein Surfaces Reveal the Multiple Recognition Patches in Protein-Protein Interactions. PMID:26690684
Composition of Overlapping Protein-Protein and Protein-Ligand Interfaces. PMID:26517868
iPPI-DB: an online database of modulators of protein-protein interactions. PMID:26432833
Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics. PMID:26378508
Molecular Docking studies of FKBP12-mTOR inhibitors using binding predictions. PMID:26229292
AlphaSpace: Fragment-Centric Topographical Mapping To Target Protein-Protein Interaction Interfaces. PMID:26225450
Surfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI Inhibitors. PMID:26111183
The paramyxovirus polymerase complex as a target for next-generation anti-paramyxovirus therapeutics. PMID:26029193
CARDIO-PRED: an in silico tool for predicting cardiovascular-disorder associated proteins. PMID:25972989
Flexibility and small pockets at protein-protein interfaces: New insights into druggability. PMID:25662442
The conundrum of the high-affinity NGF binding site formation unveiled? PMID:25650935
The re-emergence of natural products for drug discovery in the genomics era. PMID:25614221
Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies? PMID:25510283
Molecular docking analysis of RN18 and VEC5 in A3G-Vif inhibition. PMID:25489169
Rational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approach. PMID:25340632
Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles. PMID:25265015
Drug-Like Protein-Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology. PMID:25254076
Structure-based inhibition of protein-protein interactions. PMID:25253637
Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. PMID:25237857
Structure-based druggability assessment of the mammalian structural proteome with inclusion of light protein flexibility. PMID:25079060
How proteins bind macrocycles. PMID:25038790
HADDOCK(2P2I): a biophysical model for predicting the binding affinity of protein-protein interaction inhibitors. PMID:24521147
2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine. PMID:24196694
Development of a fluorescent monoclonal antibody-based assay to measure the allosteric effects of synthetic peptides on self-oligomerization of AGR2 protein. PMID:23780840
TIMBAL v2: update of a database holding small molecules modulating protein-protein interactions. PMID:23766369 -
Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database
PubMed citations: 48.
48 articles citing: Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database
The design and development of covalent protein-protein interaction inhibitors for cancer treatment. PMID:32228680
Discovery of Inhibitors for Proliferating Cell Nuclear Antigen Using a Computational-Based Linked-Multiple-Fragment Screen. PMID:31552364
Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. PMID:31276567
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein. PMID:30740315
Chemical Space Overlap with Critical Protein-Protein Interface Residues in Commercial and Specialized Small-Molecule Libraries. PMID:30548204
Evolution of In Silico Strategies for Protein-Protein Interaction Drug Discovery. PMID:30082644
Toward Small-Molecule Inhibition of Protein-Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions. PMID:29848279
MEGADOCK-Web: an integrated database of high-throughput structure-based protein-protein interaction predictions. PMID:29745830
Essential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions. PMID:28662026
How order and disorder within paramyxoviral nucleoproteins and phosphoproteins orchestrate the molecular interplay of transcription and replication. PMID:28600653
"Solvent hydrogen-bond occlusion": A new model of polar desolvation for biomolecular energetics. PMID:28318014
Imbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors. PMID:27034268
2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions. PMID:26980515
An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces. PMID:26730437
Enhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein Interactions. PMID:26484863
AlphaSpace: Fragment-Centric Topographical Mapping To Target Protein-Protein Interaction Interfaces. PMID:26225450
Fractal Dimensions of Macromolecular Structures. PMID:26213587
Structural Disorder within Paramyxoviral Nucleoproteins and Phosphoproteins in Their Free and Bound Forms: From Predictions to Experimental Assessment. PMID:26184170
DARC 2.0: Improved Docking and Virtual Screening at Protein Interaction Sites. PMID:26181386
Computational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex. PMID:25822046
Flexibility and small pockets at protein-protein interfaces: New insights into druggability. PMID:25662442
Crystal structure of the human fatty acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition. PMID:25301948
Break CDK2/Cyclin E1 interface allosterically with small peptides. PMID:25290691
HADDOCK(2P2I): a biophysical model for predicting the binding affinity of protein-protein interaction inhibitors. PMID:24521147
2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine. PMID:24196694
The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth. PMID:24142503
Structural properties of non-traditional drug targets present new challenges for virtual screening. PMID:23879197
Structural basis for LMO2-driven recruitment of the SCL:E47bHLH heterodimer to hematopoietic-specific transcriptional targets. PMID:23831025
Computational analysis of protein-protein interfaces involving an alpha helix: insights for terphenyl-like molecules binding. PMID:23768251
TIMBAL v2: update of a database holding small molecules modulating protein-protein interactions. PMID:23766369
Computational analysis of C-reactive protein for assessment of molecular dynamics and interaction properties. PMID:23494263
Using a fragment-based approach to target protein-protein interactions. PMID:23344974
Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions. PMID:23267671
On the binding affinity of macromolecular interactions: daring to ask why proteins interact. PMID:23235262
2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions. PMID:23203891
Dr. PIAS 2.0: an update of a database of predicted druggable protein-protein interactions. PMID:23060433
Virus-host interactomes--antiviral drug discovery. PMID:23057872
Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity. PMID:22831787
Fine-tuning multiprotein complexes using small molecules. PMID:22725693
A leap into the chemical space of protein-protein interaction inhibitors. PMID:22650260
Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors. PMID:22497421
Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets. PMID:22417279
Small-molecule inhibitor starting points learned from protein-protein interaction inhibitor structure. PMID:22210869
Modulating protein-protein interactions with small molecules: the importance of binding hotspots. PMID:22198293
Exploring NMR ensembles of calcium binding proteins: perspectives to design inhibitors of protein-protein interactions. PMID:21569443
Targeting protein-protein interactions for parasite control. PMID:21556146
Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions. PMID:21303559
Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors. PMID:20712375 - http://dx.doi.org/10.1093/nar/gks1002
Tags:
Tags
More detailed information about this field from each metasource.
protein interaction
metasource: Fairsharing.org
version: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
structure
metasource: Fairsharing.org
version: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
structure databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
protein structure
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Tags
More detailed information about this field from each metasource.
protein interaction
metasource: Fairsharing.orgversion: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
structure
metasource: Fairsharing.orgversion: FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
structure databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
protein structure
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
protein interaction structure structure protein structure
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