Next-Generation Grade and Survival Expression Biomarkers of Human Gliomas Based on Algorithmically Reconstructed Molecular Pathways.
PMID:35806337
Toxic Metabolites and Inborn Errors of Amino Acid Metabolism: What One Informs about the Other.
PMID:35736461
In Situ Assembly of Platinum(II)-Metallopeptide Nanostructures Disrupts Energy Homeostasis and Cellular Metabolism.
PMID:35729777
OncoboxPD: human 51 672 molecular pathways database with tools for activity calculating and visualization.
PMID:35615022
BioUML-towards a universal research platform.
PMID:35536253
HIV-Sheltering Platelets From Immunological Non-Responders Induce a Dysfunctional Glycolytic CD4+ T-Cell Profile.
PMID:35222352
Establishment and characterization of prostate organoids from treatment-naïve patients with prostate cancer.
PMID:34820005
IID 2021: towards context-specific protein interaction analyses by increased coverage, enhanced annotation and enrichment analysis.
PMID:34755877
GPRuler: Metabolic gene-protein-reaction rules automatic reconstruction.
PMID:34748537
KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism.
PMID:34402428
MitopatHs: a new logically-framed tool for visualizing multiple mitochondrial pathways.
PMID:33889820
System-wide identification and prioritization of enzyme substrates by thermal analysis.
PMID:33637753
Algorithmic Annotation of Functional Roles for Components of 3,044 Human Molecular Pathways.
PMID:33633781
Epidermal Growth Factor Is Essential for the Maintenance of Novel Prostate Epithelial Cells Isolated From Patient-Derived Organoids.
PMID:33195205
Expression, Purification, Refolding, and Characterization of a Neverland Protein From Caenorhabditis elegans.
PMID:33195160
Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy.
PMID:33173052
VARAdb: a comprehensive variation annotation database for human.
PMID:33095866
MICA enhances sensitivity to cisplatin in patients with extensive small cell lung cancer via downregulation of ABCG2.
PMID:32724354
Antioxidant Activity of Synthetic Polymers of Phenolic Compounds.
PMID:32722059
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.
PMID:32694731
Genetic Markers for Later Remission in Response to Early Improvement of Antidepressants.
PMID:32664413
Metabolomics and Multi-Omics Integration: A Survey of Computational Methods and Resources.
PMID:32429287
Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation.
PMID:32386122
Large-Scale Differential Gene Expression Transcriptomic Analysis Identifies a Metabolic Signature Shared by All Cancer Cells.
PMID:32365991
Neutrophil Extracellular Trap Induced Dendritic Cell Activation Leads to Th1 Polarization in Type 1 Diabetes.
PMID:32346380
Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine.
PMID:32296688
Transcriptomic and Genomic Testing to Guide Individualized Treatment in Chemoresistant Gastric Cancer Case.
PMID:32210001
CaMeRe: A Novel Tool for Inference of Cancer Metabolic Reprogramming.
PMID:32161720
Exploring Integrative Analysis Using the BioMedical Evidence Graph.
PMID:32097025
Molecular heterogeneity in breast carcinoma cells with increased invasive capacities.
PMID:32061169
RNA sequencing profiles and diagnostic signatures linked with response to ramucirumab in gastric cancer.
PMID:32060041
Mutation Enrichment and Transcriptomic Activation Signatures of 419 Molecular Pathways in Cancer.
PMID:31979117
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
PMID:31911677
The plasma metabolome of women in early pregnancy differs from that of non-pregnant women.
PMID:31726468
Pathway Commons 2019 Update: integration, analysis and exploration of pathway data.
PMID:31647099
Gene connectivity and enzyme evolution in the human metabolic network.
PMID:31481097
A meta-analysis of multiple matched aCGH/expression cancer datasets reveals regulatory relationships and pathway enrichment of potential oncogenes.
PMID:31335867
Human Systems Biology and Metabolic Modelling: A Review-From Disease Metabolism to Precision Medicine.
PMID:31281846
Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study.
PMID:31179255
Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis.
PMID:31053723
Genes with High Network Connectivity Are Enriched for Disease Heritability.
PMID:31051114
The MACADAM database: a MetAboliC pAthways DAtabase for Microbial taxonomic groups for mining potential metabolic capacities of archaeal and bacterial taxonomic groups.
PMID:31032842
The Transcriptomic Toolbox: Resources for Interpreting Large Gene Expression Data within a Precision Medicine Context for Metabolic Disease Atherosclerosis.
PMID:31032818
BZW2 gene knockdown induces cell growth inhibition, G1 arrest and apoptosis in muscle-invasive bladder cancers: A microarray pathway analysis.
PMID:30932331
netDx: interpretable patient classification using integrated patient similarity networks.
PMID:30872331
Pathway Based Analysis of Mutation Data Is Efficient for Scoring Target Cancer Drugs.
PMID:30728774
Ulcerative colitis: functional analysis of the in-depth proteome.
PMID:30718987
Integrative Analyses of Genes Associated with Subcutaneous Insulin Resistance.
PMID:30678306
Pathway Instability Is an Effective New Mutation-Based Type of Cancer Biomarkers.
PMID:30662873
Influence of pathway topology and functional class on the molecular evolution of human metabolic genes.
PMID:30550546
Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD.
PMID:30459441
Establishing normal metabolism and differentiation in hepatocellular carcinoma cells by culturing in adult human serum.
PMID:30076349
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
PMID:29892016
Patient Similarity Networks for Precision Medicine.
PMID:29860027
GFPT2-Expressing Cancer-Associated Fibroblasts Mediate Metabolic Reprogramming in Human Lung Adenocarcinoma.
PMID:29760045
A review of computational tools for design and reconstruction of metabolic pathways.
PMID:29552648
From correlation to causation: analysis of metabolomics data using systems biology approaches.
PMID:29503602
Evaluation and comparison of bioinformatic tools for the enrichment analysis of metabolomics data.
PMID:29291722
MitoCore: a curated constraint-based model for simulating human central metabolism.
PMID:29178872
Modelling pyruvate dehydrogenase under hypoxia and its role in cancer metabolism.
PMID:29134060
Association analysis identifies 65 new breast cancer risk loci.
PMID:29059683
Chronic obstructive pulmonary disease candidate gene prioritization based on metabolic networks and functional information.
PMID:28873096
Advances in metabolome information retrieval: turning chemistry into biology. Part II: biological information recovery.
PMID:28842777
Aspergillus Secondary Metabolite Database, a resource to understand the Secondary metabolome of Aspergillus genus.
PMID:28779078
YAP suppresses gluconeogenic gene expression through PGC1α.
PMID:28714135
NFPscanner: a webtool for knowledge-based deciphering of biomedical networks.
PMID:28521733
ADH1B: From alcoholism, natural selection, and cancer to the human phenome.
PMID:28349588
A Comprehensive Gene Expression Meta-analysis Identifies Novel Immune Signatures in Rheumatoid Arthritis Patients.
PMID:28210261
Systematic analyses of drugs and disease indications in RepurposeDB reveal pharmacological, biological and epidemiological factors influencing drug repositioning.
PMID:28200013
Sparse network modeling and metscape-based visualization methods for the analysis of large-scale metabolomics data.
PMID:28137712
Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism.
PMID:27966532
Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling.
PMID:27697518
Antioxidant-rich leaf extract of Barringtonia racemosa significantly alters the in vitro expression of genes encoding enzymes that are involved in methylglyoxal degradation III.
PMID:27635343
The metabolic background is a global player in Saccharomyces gene expression epistasis.
PMID:27572163
Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.
PMID:27559084
Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington's disease peripheral blood samples.
PMID:27524956
Clinical Metabolomics: The New Metabolic Window for Inborn Errors of Metabolism Investigations in the Post-Genomic Era.
PMID:27447622
ArthropodaCyc: a CycADS powered collection of BioCyc databases to analyse and compare metabolism of arthropods.
PMID:27242037
Changes in plasma metabolites and glucose homeostasis during omega-3 polyunsaturated fatty acid supplementation in women with polycystic ovary syndrome.
PMID:27182493
Pathway analysis in attention deficit hyperactivity disorder: An ensemble approach.
PMID:27004716
Representation and inference of cellular architecture for metabolic reconstruction and modeling.
PMID:26628588
Towards improved genome-scale metabolic network reconstructions: unification, transcript specificity and beyond.
PMID:26615025
A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease.
PMID:26504511
Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network.
PMID:26480823
Longitudinal omics modeling and integration in clinical metabonomics research: challenges in childhood metabolic health research.
PMID:26301225
Human metabolic atlas: an online resource for human metabolism.
PMID:26209309
Using gene expression signatures to identify novel treatment strategies in gulf war illness.
PMID:26156520
Visualisation of BioPAX Networks using BioLayout Express (3D).
PMID:25949802
Measuring semantic similarities by combining gene ontology annotations and gene co-function networks.
PMID:25886899
Metabolomics and diabetes: analytical and computational approaches.
PMID:25713200
Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease.
PMID:25528190
Transcriptome alterations of mitochondrial and coagulation function in schizophrenia by cortical sequencing analysis.
PMID:25522158
Computational strategies for a system-level understanding of metabolism.
PMID:25427076
Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease.
PMID:25386055
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
PMID:25383517
Identifying common components across biological network graphs using a bipartite data model.
PMID:25374613
TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
PMID:25300491
Comparative network analysis via differential graphlet communities.
PMID:25283527
Maternal obesity and tobacco use modify the impact of genetic variants on the occurrence of conotruncal heart defects.
PMID:25275547
Predicting interactome network perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia.
PMID:25273558
Concept mapping One-Carbon Metabolism to model future ontologies for nutrient-gene-phenotype interactions.
PMID:25091042
Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic network.
PMID:25061554
MetDisease--connecting metabolites to diseases via literature.
PMID:24713438
Chemical structure identification in metabolomics: computational modeling of experimental features.
PMID:24688698
Prediction of individualized therapeutic vulnerabilities in cancer from genomic profiles.
PMID:24665131
Detection of type 2 diabetes related modules and genes based on epigenetic networks.
PMID:24565181
Comparing the Chemical Structure and Protein Content of ChEMBL, DrugBank, Human Metabolome Database and the Therapeutic Target Database.
PMID:24533037
Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.
PMID:24336226
Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles.
PMID:24320595
Controllability in cancer metabolic networks according to drug targets as driver nodes.
PMID:24282504
Using random walks to identify cancer-associated modules in expression data.
PMID:24128261
Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease.
PMID:24098138
In silico enzymatic synthesis of a 400,000 compound biochemical database for nontargeted metabolomics.
PMID:23991755
metabolicMine: an integrated genomics, genetics and proteomics data warehouse for common metabolic disease research.
PMID:23935057
3Omics: a web-based systems biology tool for analysis, integration and visualization of human transcriptomic, proteomic and metabolomic data.
PMID:23875761
A network-based approach for predicting key enzymes explaining metabolite abundance alterations in a disease phenotype.
PMID:23870038
An integrative framework for Bayesian variable selection with informative priors for identifying genes and pathways.
PMID:23844055
Consensus and conflict cards for metabolic pathway databases.
PMID:23803311
Pathway databases: making chemical and biological sense of the genomic data flood.
PMID:23706629
GeneSetDB: A comprehensive meta-database, statistical and visualisation framework for gene set analysis.
PMID:23650583
CMS: a web-based system for visualization and analysis of genome-wide methylation data of human cancers.
PMID:23630576
Heterogeneity of tumor-induced gene expression changes in the human metabolic network.
PMID:23604282
Network pharmacology strategies toward multi-target anticancer therapies: from computational models to experimental design principles.
PMID:23530504
Integration of clinical data with a genome-scale metabolic model of the human adipocyte.
PMID:23511207
SPPS resins impact the PNA-syntheses' improvement.
PMID:23423830
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.
PMID:23384594
Integrated testing strategies for safety assessments.
PMID:23338803
BioSM: metabolomics tool for identifying endogenous mammalian biochemical structures in chemical structure space.
PMID:23330685
Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation.
PMID:23324130
An integrative approach to inferring gene regulatory module networks.
PMID:23285197
IntPath--an integrated pathway gene relationship database for model organisms and important pathogens.
PMID:23282057
HMDB 3.0--The Human Metabolome Database in 2013.
PMID:23161693
Pathway Distiller - multisource biological pathway consolidation.
PMID:23134636
Associations between maternal genotypes and metabolites implicated in congenital heart defects.
PMID:23059056
Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species.
PMID:23019649
The genetics of alcohol dependence: advancing towards systems-based approaches.
PMID:22854292
DEFOG: discrete enrichment of functionally organized genes.
PMID:22706384
Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT.
PMID:22615553
Construction and completion of flux balance models from pathway databases.
PMID:22262672
Stable isotope-resolved metabolomics and applications for drug development.
PMID:22212615
Advanced stoichiometric analysis of metabolic networks of mammalian systems.
PMID:22196224
Novel search method for the discovery of functional relationships.
PMID:22180409
MMMDB: Mouse Multiple Tissue Metabolome Database.
PMID:22139941
Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data.
PMID:22135418
DNAtraffic--a new database for systems biology of DNA dynamics during the cell life.
PMID:22110027
Critical assessment of human metabolic pathway databases: a stepping stone for future integration.
PMID:21999653
Structural diversity of biologically interesting datasets: a scaffold analysis approach.
PMID:21824432
A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle.
PMID:21714867
A survey of metabolic databases emphasizing the MetaCyc family.
PMID:21523460
Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells.
PMID:21483477
Modeling cholesterol metabolism by gene expression profiling in the hippocampus.
PMID:21451815
Network analysis of human protein location.
PMID:21106131
Pathway Commons, a web resource for biological pathway data.
PMID:21071392
A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1.
PMID:20959003
Prediction of human protein-protein interaction by a mixed Bayesian model and its application to exploring underlying cancer-related pathway crosstalk.
PMID:20943681
Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension.
PMID:20942928
The BioPAX community standard for pathway data sharing.
PMID:20829833
Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network.
PMID:20823846
Computational reconstruction of tissue-specific metabolic models: application to human liver metabolism.
PMID:20823844
Compartmentalization of the Edinburgh Human Metabolic Network.
PMID:20649990
Somatic polyploidy promotes cell function under stress and energy depletion: evidence from tissue-specific mammal transcriptome.
PMID:20625914
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function.
PMID:20576703
Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining.
PMID:20526351
MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks.
PMID:20444866
Consolidating metabolite identifiers to enable contextual and multi-platform metabolomics data analysis.
PMID:20426876
Improved microarray-based decision support with graph encoded interactome data.
PMID:20419106
Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology.
PMID:19955237
The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases.
PMID:19850718
HPD: an online integrated human pathway database enabling systems biology studies.
PMID:19811689
A mapping of drug space from the viewpoint of small molecule metabolism.
PMID:19701464
MouseCyc: a curated biochemical pathways database for the laboratory mouse.
PMID:19682380
The conservation and evolutionary modularity of metabolism.
PMID:19523219
LeishCyc: a biochemical pathways database for Leishmania major.
PMID:19497128
Database resources in metabolomics: an overview.
PMID:19418229
Reconstruction of metabolic pathways for the cattle genome.
PMID:19284618
ConsensusPathDB--a database for integrating human functional interaction networks.
PMID:18940869
PID: the Pathway Interaction Database.
PMID:18832364
A combined computational-experimental analyses of selected metabolic enzymes in Pseudomonas species.
PMID:18802474
Gene Vector Analysis (Geneva): a unified method to detect differentially-regulated gene sets and similar microarray experiments.
PMID:18721468
Meta-analysis approach identifies candidate genes and associated molecular networks for type-2 diabetes mellitus.
PMID:18590522
Analysis of Aspergillus nidulans metabolism at the genome-scale.
PMID:18405346
An ontology-driven semantic mashup of gene and biological pathway information: application to the domain of nicotine dependence.
PMID:18395495
Photosensitivity in Smith-Lemli-Opitz syndrome: a flux balance analysis of altered metabolism.
PMID:18188427
Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia.
PMID:18070347
The MetaCyc Database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases.
PMID:17965431
The Edinburgh human metabolic network reconstruction and its functional analysis.
PMID:17882155
Organismal complexity, cell differentiation and gene expression: human over mouse.
PMID:17881362
A survey of orphan enzyme activities.
PMID:17623104
Metabolic network visualization eliminating node redundance and preserving metabolic pathways.
PMID:17608928
e-Science and biological pathway semantics.
PMID:17493286
Reactome: a knowledge base of biologic pathways and processes.
PMID:17367534
From bytes to bedside: data integration and computational biology for translational cancer research.
PMID:17319736
Global reconstruction of the human metabolic network based on genomic and bibliomic data.
PMID:17267599
'Genome design' model and multicellular complexity: golden middle.
PMID:17062620
The Cinderella story of metabolic profiling: does metabolomics get to go to the functional genomics ball?
PMID:16553314
WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data.
PMID:16423281
MetaCyc: a multiorganism database of metabolic pathways and enzymes.
PMID:16381923
Expansion of the BioCyc collection of pathway/genome databases to 160 genomes.
PMID:16246909