Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination.
PMID:35927700
CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma.
PMID:35844805
Single-cell specific and interpretable machine learning models for sparse scChIP-seq data imputation.
PMID:35776722
TWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in glioma.
PMID:35694846
ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge's disease.
PMID:35672450
3D genome organization in the epithelial-mesenchymal transition spectrum.
PMID:35637517
DeepSTARR predicts enhancer activity from DNA sequence and enables the de novo design of synthetic enhancers.
PMID:35551305
Multiple sclerosis genetic and non-genetic factors interact through the transient transcriptome.
PMID:35534508
The 4D Nucleome Data Portal as a resource for searching and visualizing curated nucleomics data.
PMID:35501320
CRISPRs in the human genome are differentially expressed between malignant and normal adjacent to tumor tissue.
PMID:35396392
Regulation of chromatin accessibility by hypoxia and HIF.
PMID:35258521
HiMoRNA: A Comprehensive Database of Human lncRNAs Involved in Genome-Wide Epigenetic Regulation.
PMID:35202091
Placental methylome reveals a 22q13.33 brain regulatory gene locus associated with autism.
PMID:35168652
KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences.
PMID:35042549
Antibody-free profiling of transcription factor occupancy during early embryogenesis by FitCUT&RUN.
PMID:34965941
GIP: an open-source computational pipeline for mapping genomic instability from protists to cancer cells.
PMID:34928370
Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation.
PMID:34922480
CoRE-ATAC: A deep learning model for the functional classification of regulatory elements from single cell and bulk ATAC-seq data.
PMID:34898596
A Transcriptional Signature of IL-2 Expanded Natural Killer Cells Predicts More Favorable Prognosis in Bladder Cancer.
PMID:34858395
Deficiency of replication-independent DNA mismatch repair drives a 5-methylcytosine deamination mutational signature in cancer.
PMID:34730999
DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity.
PMID:34706222
Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation and is altered with age.
PMID:34687484
Deficiencies in the DNA Binding Protein ARID3a Alter Chromatin Structures Important for Early Human Erythropoiesis.
PMID:34663594
DNA methylation-calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluation.
PMID:34663425
Detection of Neanderthal Adaptively Introgressed Genetic Variants That Modulate Reporter Gene Expression in Human Immune Cells.
PMID:34662402
Diverse functional elements in RNA predicted transcriptome-wide by orthogonal RNA structure probing.
PMID:34634799
Metabolic gene regulation by Drosophila GATA transcription factor Grain.
PMID:34634038
Identification and Functional Characterization of Two Noncoding RNAs Transcribed from Putative Active Enhancers in Hepatocellular Carcinoma.
PMID:34588321
High frequency of intron retention and clustered H3K4me3-marked nucleosomes in short first introns of human long non-coding RNAs.
PMID:34579770
A Transcriptional Signature of PDGF-DD Activated Natural Killer Cells Predicts More Favorable Prognosis in Low-Grade Glioma.
PMID:34539622
RNAProt: an efficient and feature-rich RNA binding protein binding site predictor.
PMID:34406415
m6Am-seq reveals the dynamic m6Am methylation in the human transcriptome.
PMID:34362929
Coding and noncoding variants in EBF3 are involved in HADDS and simplex autism.
PMID:34256850
ANANSE: an enhancer network-based computational approach for predicting key transcription factors in cell fate determination.
PMID:34244796
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.
PMID:34216543
Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.
PMID:34133714
GRiNCH: simultaneous smoothing and detection of topological units of genome organization from sparse chromatin contact count matrices with matrix factorization.
PMID:34034791
Regulatory rare variants of the dopaminergic gene ANKK1 as potential risk factors for Parkinson's disease.
PMID:33972609
Chromatin remodeller CHD7 is required for GABAergic neuron development by promoting PAQR3 expression.
PMID:33900016
Conserved long-range base pairings are associated with pre-mRNA processing of human genes.
PMID:33863890
Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms.
PMID:33852859
Functional annotation of lung cancer‒associated genetic variants by cell type‒specific epigenome and long-range chromatin interactome.
PMID:33840167
An extended catalogue of tandem alternative splice sites in human tissue transcriptomes.
PMID:33826604
A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation.
PMID:33823549
Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex.
PMID:33789096
Effects of sheared chromatin length on ChIP-seq quality and sensitivity.
PMID:33788948
Cell type-specific chromatin accessibility analysis in the mouse and human brain.
PMID:33775205
Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis.
PMID:33693641
Reactive astrocytes in ALS display diminished intron retention.
PMID:33684213
Integrated genomic analysis reveals regulatory pathways and dynamic landscapes of the tRNA transcriptome.
PMID:33664286
Annotation of chromatin states in 66 complete mouse epigenomes during development.
PMID:33619351
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer.
PMID:33517887
MicroExonator enables systematic discovery and quantification of microexons across mouse embryonic development.
PMID:33482885
Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing.
PMID:33462199
Transcriptome-wide high-throughput mapping of protein-RNA occupancy profiles using POP-seq.
PMID:33441968
First insights into the molecular basis association between promoter polymorphisms of the IL1B gene and Helicobacter pylori infection in the Sudanese population: computational approach.
PMID:33413117
Bipartite regulation of cellular communication network factor 2 and fibroblast growth factor 1 genes by fibroblast growth factor 1 through histone deacetylase 1 and fork head box protein A1.
PMID:33398720
Evaluation of Male Fertility-Associated Loci in a European Population of Patients with Severe Spermatogenic Impairment.
PMID:33383876
CellO: comprehensive and hierarchical cell type classification of human cells with the Cell Ontology.
PMID:33364592
Improving CLIP-seq data analysis by incorporating transcript information.
PMID:33334306
Identifying chromatin features that regulate gene expression distribution.
PMID:33239733
Genetic associations of in vivo pathology influence Alzheimer's disease susceptibility.
PMID:33213512
Dedifferentiation and neuronal repression define familial Alzheimer's disease.
PMID:33188013
FOXL1 Regulates Lung Fibroblast Function via Multiple Mechanisms.
PMID:32946266
Alteration of genome folding via contact domain boundary insertion.
PMID:32868908
A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis.
PMID:32859762
Single-Cell Sequencing of Mouse Thymocytes Reveals Mutational Landscape Shaped by Replication Errors, Mismatch Repair, and H3K36me3.
PMID:32858340
The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes.
PMID:32811853
Expanded encyclopaedias of DNA elements in the human and mouse genomes.
PMID:32728249
An atlas of dynamic chromatin landscapes in mouse fetal development.
PMID:32728240
Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cells.
PMID:32710817
NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli.
PMID:32683448
Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells.
PMID:32565358
Sex Chromosomes and Sex Phenotype Contribute to Biased DNA Methylation in Mouse Liver.
PMID:32527045
Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes.
PMID:32469866
UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide.
PMID:32439635
Analysis of Putative Epigenetic Regulatory Elements in the FXN Genomic Locus.
PMID:32408537
CNN-Peaks: ChIP-Seq peak detection pipeline using convolutional neural networks that imitate human visual inspection.
PMID:32404971
HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6.
PMID:32344511
Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.
PMID:32324168
Management, Analyses, and Distribution of the MaizeCODE Data on the Cloud.
PMID:32296450
Transcriptional Patterning of the Ventricular Cardiac Conduction System.
PMID:32290757
LARP1 isoform expression in human cancer cell lines.
PMID:32286153
Quantification, Dynamic Visualization, and Validation of Bias in ATAC-Seq Data with ataqv.
PMID:32213349
Testing Proximity of Genomic Regions to Transcription Start Sites and Enhancers Complements Gene Set Enrichment Testing.
PMID:32211031
An epilepsy-associated mutation in the nuclear import receptor KPNA7 reduces nuclear localization signal binding.
PMID:32179771
*-DCC: A platform to collect, annotate, and explore a large variety of sequencing experiments.
PMID:32170312
NR2F2 Orphan Nuclear Receptor is Involved in Estrogen Receptor Alpha-Mediated Transcriptional Regulation in Luminal A Breast Cancer Cells.
PMID:32168782
Reprogramming of macrophages employing gene regulatory and metabolic network models.
PMID:32097424
Dual threshold optimization and network inference reveal convergent evidence from TF binding locations and TF perturbation responses.
PMID:32060051
pyBedGraph: a python package for fast operations on 1D genomic signal tracks.
PMID:32044918
EHMT2 Inhibition Induces Cell Death in Human Non-Small Cell Lung Cancer by Altering the Cholesterol Biosynthesis Pathway.
PMID:32028644
Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.
PMID:32012149
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance.
PMID:31949051
ASCOT identifies key regulators of neuronal subtype-specific splicing.
PMID:31919425
Integrative network analysis identifies cell-specific trans regulators of m6A.
PMID:31912146
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
PMID:31911677
The epigenomic landscape of transposable elements across normal human development and anatomy.
PMID:31822674
MeCP2 Represses Enhancers through Chromosome Topology-Associated DNA Methylation.
PMID:31784360
LncRNA SNHG15: A new budding star in human cancers.
PMID:31774607
Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.
PMID:31755685
The ENCODE Portal as an Epigenomics Resource.
PMID:31751002
New developments on the Encyclopedia of DNA Elements (ENCODE) data portal.
PMID:31713622
Genome-wide quantification of ADAR adenosine-to-inosine RNA editing activity.
PMID:31636457
SEAweb: the small RNA Expression Atlas web application.
PMID:31598718
The RNA-binding protein ILF3 binds to transposable element sequences in SINEUP lncRNAs.
PMID:31570000
SliceIt: A genome-wide resource and visualization tool to design CRISPR/Cas9 screens for editing protein-RNA interaction sites in the human genome.
PMID:31494246
H3K4me3, H3K9ac, H3K27ac, H3K27me3 and H3K9me3 Histone Tags Suggest Distinct Regulatory Evolution of Open and Condensed Chromatin Landmarks.
PMID:31491936
A de novo evolved gene in the house mouse regulates female pregnancy cycles.
PMID:31436535
Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced somatic mutation rates in survival outliers of glioblastoma.
PMID:31159876
Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids.
PMID:31155493
ImmuneRegulation: a web-based tool for identifying human immune regulatory elements.
PMID:31114925
RegulationSpotter: annotation and interpretation of extratranscriptic DNA variants.
PMID:31106382
Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy.
PMID:31095341
Profiling of chromatin accessibility and identification of general cis-regulatory mechanisms that control two ocular lens differentiation pathways.
PMID:31053165
scMatch: a single-cell gene expression profile annotation tool using reference datasets.
PMID:31028376
LightCpG: a multi-view CpG sites detection on single-cell whole genome sequence data.
PMID:31014252
Applications of ENCODE data to Systematic Analyses via Data Integration.
PMID:31011690
Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study.
PMID:31009952
Clinical application of next-generation sequencing to the practice of neurology.
PMID:30981321
Systems Biology Reveals NR2F6 and TGFB1 as Key Regulators of Feed Efficiency in Beef Cattle.
PMID:30967894
The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration.
PMID:30923168
AlleleHMM: a data-driven method to identify allele specific differences in distributed functional genomic marks.
PMID:30918970
Integrative transcriptomic analysis suggests new autoregulatory splicing events coupled with nonsense-mediated mRNA decay.
PMID:30916337
ChIPulate: A comprehensive ChIP-seq simulation pipeline.
PMID:30897079
EZH2 Inhibition in Ewing Sarcoma Upregulates GD2 Expression for Targeting with Gene-Modified T Cells.
PMID:30879952
Haplotype-resolved and integrated genome analysis of the cancer cell line HepG2.
PMID:30864654
Reproducible inference of transcription factor footprints in ATAC-seq and DNase-seq datasets using protocol-specific bias modeling.
PMID:30791920
Ribosomal DNA harbors an evolutionarily conserved clock of biological aging.
PMID:30765617
Comprehensive, integrated, and phased whole-genome analysis of the primary ENCODE cell line K562.
PMID:30737237
Retroelement-Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution.
PMID:30736359
Probing transcription factor combinatorics in different promoter classes and in enhancers.
PMID:30709337
Role of Segregation for Variant Discovery in Multiplex Families Ascertained by Probands With Left Sided Cardiovascular Malformations.
PMID:30687393
DASHR 2.0: integrated database of human small non-coding RNA genes and mature products.
PMID:30668832
Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association.
PMID:30597065
TICA: Transcriptional Interaction and Coregulation Analyzer.
PMID:30578913
Human genome-wide measurement of drug-responsive regulatory activity.
PMID:30575722
Characterizing the nuclease accessibility of DNA in human cells to map higher order structures of chromatin.
PMID:30496478
RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data.
PMID:30445601
Splicing of long non-coding RNAs primarily depends on polypyrimidine tract and 5' splice-site sequences due to weak interactions with SR proteins.
PMID:30445574
The UCSC Genome Browser database: 2019 update.
PMID:30407534
Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches.
PMID:30345087
Nervous System Regionalization Entails Axial Allocation before Neural Differentiation.
PMID:30343898
CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops.
PMID:30296942
A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains.
PMID:30266094
Identification of a functional antioxidant response element at the HIF1A locus.
PMID:30241031
Genome-wide DNA methylation profiling of primary colorectal laterally spreading tumors identifies disease-specific epimutations on common pathways.
PMID:30183087
Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci.
PMID:30146127
Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations.
PMID:30139389
Bioinformatics analysis of microarray data to reveal the pathogenesis of diffuse intrinsic pontine glioma.
PMID:30124166
Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing.
PMID:30078707
Tracing human stem cell lineage during development using DNA methylation.
PMID:30072366
Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture.
PMID:30048462
Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids.
PMID:29983891
CRISPR/Cas9-mediated knock-in of an optimized TetO repeat for live cell imaging of endogenous loci.
PMID:29912475
Comprehensive comparative analysis of 5'-end RNA-sequencing methods.
PMID:29867192
Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS.
PMID:29789581
SINHCAF/FAM60A and SIN3A specifically repress HIF-2α expression.
PMID:29784889
REGGAE: a novel approach for the identification of key transcriptional regulators.
PMID:29741575
SPAR: small RNA-seq portal for analysis of sequencing experiments.
PMID:29733404
Global profiling of protein-DNA and protein-nucleosome binding affinities using quantitative mass spectrometry.
PMID:29695722
Prevention of data duplication for high throughput sequencing repositories.
PMID:29688363
DIVERSITY in binding, regulation, and evolution revealed from high-throughput ChIP.
PMID:29684008
Mammalian genomic regulatory regions predicted by utilizing human genomics, transcriptomics, and epigenetics data.
PMID:29618048
TISSUES 2.0: an integrative web resource on mammalian tissue expression.
PMID:29617745
A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes.
PMID:29605715
HnRNP L represses cryptic exons.
PMID:29581412
Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes.
PMID:29561703
STAT3 precedes HIF1α transcriptional responses to oxygen and oxygen and glucose deprivation in human brain pericytes.
PMID:29518129
Profiling of Human Molecular Pathways Affected by Retrotransposons at the Level of Regulation by Transcription Factor Proteins.
PMID:29441061
ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream of transcription start sites at the majority of CpG island promoters.
PMID:29429977
PureCLIP: capturing target-specific protein-RNA interaction footprints from single-nucleotide CLIP-seq data.
PMID:29284540
THiCweed: fast, sensitive detection of sequence features by clustering big datasets.
PMID:29267972
Binding of high mobility group A proteins to the mammalian genome occurs as a function of AT-content.
PMID:29267285
A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons.
PMID:29158107
rSNPBase 3.0: an updated database of SNP-related regulatory elements, element-gene pairs and SNP-based gene regulatory networks.
PMID:29140525
The Encyclopedia of DNA elements (ENCODE): data portal update.
PMID:29126249
De Novo Missense Mutations in DHX30 Impair Global Translation and Cause a Neurodevelopmental Disorder.
PMID:29100085
Chromatin interaction networks revealed unique connectivity patterns of broad H3K4me3 domains and super enhancers in 3D chromatin.
PMID:29089515
Loci associated with skin pigmentation identified in African populations.
PMID:29025994
Gene Regulatory Enhancers with Evolutionarily Conserved Activity Are More Pleiotropic than Those with Species-Specific Activity.
PMID:28985297
Nucleoplasmic Nup98 controls gene expression by regulating a DExH/D-box protein.
PMID:28934014
Next-Generation Sequencing: The Translational Medicine Approach from "Bench to Bedside to Population".
PMID:28930123
HiCRep: assessing the reproducibility of Hi-C data using a stratum-adjusted correlation coefficient.
PMID:28855260
microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells.
PMID:28774347
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.
PMID:28628103
DNA methylation-based chromatin compartments and ChIP-seq profiles reveal transcriptional drivers of prostate carcinogenesis.
PMID:28592290
Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth.
PMID:28583252
The elephant shark methylome reveals conservation of epigenetic regulation across jawed vertebrates.
PMID:28580133
The microprotein Minion controls cell fusion and muscle formation.
PMID:28569745
Transcriptomics technologies.
PMID:28545146
RegulatorTrail: a web service for the identification of key transcriptional regulators.
PMID:28472408
SnoVault and encodeD: A novel object-based storage system and applications to ENCODE metadata.
PMID:28403240
LncFunNet: an integrated computational framework for identification of functional long noncoding RNAs in mouse skeletal muscle cells.
PMID:28379566
An atlas of human long non-coding RNAs with accurate 5' ends.
PMID:28241135
Dynamic chromatin accessibility modeled by Markov process of randomly-moving molecules in the 3D genome.
PMID:28180283
An Improved Method for Identifying Specific DNA-Protein-Binding Sites In Vitro.
PMID:28132389
A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers.
PMID:28112740
The UCSC Genome Browser database: 2017 update.
PMID:27899642
Using GWAS to identify novel therapeutic targets for osteoporosis.
PMID:27837649
A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity.
PMID:27831498
Exploration and detection of potential regulatory variants in refractive error GWAS.
PMID:27604318
Genetic Susceptibility to Bortezomib-Induced Peripheral Neuroropathy: Replication of the Reported Candidate Susceptibility Loci.
PMID:27422265
The Cell Ontology 2016: enhanced content, modularization, and ontology interoperability.
PMID:27377652
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update.
PMID:27141961
The RNA 3D Motif Atlas: Computational methods for extraction, organization and evaluation of RNA motifs.
PMID:27125735
Resources for the Comprehensive Discovery of Functional RNA Elements.
PMID:26990993
Principles of metadata organization at the ENCODE data coordination center.
PMID:26980513