HotSpotAnnotations
Other names: hotspotannotations
Database for hotspot mutations and annotations in cancer. Hotspots, recurrently mutated DNA positions in cancer, are thought to be oncogenic drivers because random chance is unlikely and the knowledge of clear examples of oncogenic hotspots in genes like BRAF, IDH1, KRAS and NRAS among many other genes. Hotspots are attractive because provide opportunities for biomedical research and novel treatments. Nevertheless, recent evidence, such as DNA hairpins for APOBEC3A, suggests that a considerable fraction of hotspots seem to be passengers rather than drivers. To document hotspots, the database HotSpotsAnnotations is proposed. For this, a statistical model was implemented to detect putative hotspots, which was applied to TCGA cancer datasets covering 33 cancer types, 10 182 patients and 3 175 929 mutations
Description
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Database for hotspot mutations and annotations in cancer. Hotspots, recurrently mutated DNA positions in cancer, are thought to be oncogenic drivers because random chance is unlikely and the knowledge of clear examples of oncogenic hotspots in genes like BRAF, IDH1, KRAS and NRAS among many other genes. Hotspots are attractive because provide opportunities for biomedical research and novel treatments. Nevertheless, recent evidence, such as DNA hairpins for APOBEC3A, suggests that a considerable fraction of hotspots seem to be passengers rather than drivers. To document hotspots, the database HotSpotsAnnotations is proposed. For this, a statistical model was implemented to detect putative hotspots, which was applied to TCGA cancer datasets covering 33 cancer types, 10 182 patients and 3 175 929 mutations
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:28:47.384474
Webpage:
http://bioinformatica.mty.itesm.mx/HotSpotAnnotationsWebpage
More detailed information about this field from each metasource.
http://bioinformatica.mty.itesm.mx/HotSpotAnnotations
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:28:47.384474
Publications:
Publications
More detailed information about this field from each metasource.
HotSpotAnnotations-a database for hotspot mutations and annotations in cancer
PMID: 32386297
metasource: bio.tools
version: extracted_at: 2022-11-04T11:28:47.384474
Publications
More detailed information about this field from each metasource.
HotSpotAnnotations-a database for hotspot mutations and annotations in cancer
PMID: 32386297
metasource: bio.tools
version: extracted_at: 2022-11-04T11:28:47.384474
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HotSpotAnnotations-a database for hotspot mutations and annotations in cancer
PubMed citations: 5.
5 articles citing: HotSpotAnnotations-a database for hotspot mutations and annotations in cancer
Mutational Characterization of Colorectal Cancer from Korean Patients with Targeted Sequencing. PMID:35003350
A mutational hotspot that determines highly repeatable evolution can be built and broken by silent genetic changes. PMID:34667151
Imprecise Medicine: BRCA2 Variants of Uncertain Significance (VUS), the Challenges and Benefits to Integrate a Functional Assay Workflow with Clinical Decision Rules. PMID:34065235
Computational methods for detecting cancer hotspots. PMID:33304455
Modeling and analysis of site-specific mutations in cancer identifies known plus putative novel hotspots and bias due to contextual sequences. PMID:32670506
Tags:
Tags
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oncology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:28:47.384474
genetic variation
metasource: bio.tools
version: extracted_at: 2022-11-04T11:28:47.384474
biological databases
metasource: bio.tools
version: extracted_at: 2022-11-04T11:28:47.384474
Tags
More detailed information about this field from each metasource.
oncology
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:28:47.384474
genetic variation
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:28:47.384474
biological databases
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:28:47.384474
oncology genetic variation biological
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