FAIRsharing.s5zmbp; Last edited: March 8, 2021, 10:32 a.m.; Last accessed: Jan 03 2022 7:08 p.m.

metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:57.636780

cosmic
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:57.636780

Other names: COSMIC, cosmic

The Catalogue of Somatic Mutations in Cancer (COSMIC) is a database of manually-curated somatic mutation information relating to human cancers. The COSMIC database combines manually-curated data and genome-wide screen data.

Webpage:

http://cancer.sanger.ac.uk

Licence:

Name: COSMIC Terms of Use and Licence
URL: https://cancer.sanger.ac.uk/cosmic/license

Publications: (7)

Publications
More detailed information about this field from each metasource.

COSMIC: exploring the world's knowledge of somatic mutations in human cancer
PMID: 25355519
metasource: Fairsharing.org
version: FAIRsharing.org: COSMIC; Catalogue of Somatic Mutations in Cancer; DOI: https://doi.org/10.25504/FAIRsharing.s5zmbp; Last edited: March 8, 2021, 10:32 a.m.; Last accessed: Jan 03 2022 7:08 p.m.

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
PMID: 20952405
metasource: Fairsharing.org
version: FAIRsharing.org: COSMIC; Catalogue of Somatic Mutations in Cancer; DOI: https://doi.org/10.25504/FAIRsharing.s5zmbp; Last edited: March 8, 2021, 10:32 a.m.; Last accessed: Jan 03 2022 7:08 p.m.

metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:57.636780

COSMIC: the Catalogue Of Somatic Mutations In Cancer
PMID: 30371878
metasource: Fairsharing.org
version: FAIRsharing.org: COSMIC; Catalogue of Somatic Mutations in Cancer; DOI: https://doi.org/10.25504/FAIRsharing.s5zmbp; Last edited: March 8, 2021, 10:32 a.m.; Last accessed: Jan 03 2022 7:08 p.m.

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
PMID: 15188009
metasource: Fairsharing.org
version: FAIRsharing.org: COSMIC; Catalogue of Somatic Mutations in Cancer; DOI: https://doi.org/10.25504/FAIRsharing.s5zmbp; Last edited: March 8, 2021, 10:32 a.m.; Last accessed: Jan 03 2022 7:08 p.m.

COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer
PMID: 19906727
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:57.636780

Data mining using the Catalogue of Somatic Mutations in Cancer BioMart
PMID: 21609966
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:57.636780

http://dx.doi.org/10.1093/nar/gku1075
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

COSMIC: exploring the world's knowledge of somatic mutations in human cancer PubMed citations: 1245.

1245 articles citing: COSMIC: exploring the world's knowledge of somatic mutations in human cancer

iCOMIC: a graphical interface-driven bioinformatics pipeline for analyzing cancer omics data. PMID:35899080
Therapeutic Potential of Intrabodies for Cancer Immunotherapy: Current Status and Future Directions. PMID:35892709
Uncovering the Contribution of Moderate-Penetrance Susceptibility Genes to Breast Cancer by Whole-Exome Sequencing and Targeted Enrichment Sequencing of Candidate Genes in Women of European Ancestry. PMID:35884425
Pan-cancer integrative analysis of whole-genome De novo somatic point mutations reveals 17 cancer types. PMID:35879674
Somatic DNA Damage Response and Homologous Repair Gene Alterations and Its Association With Tumor Variant Burden in Breast Cancer Patients With Occupational Exposure to Pesticides. PMID:35875117
Clinical, histopathological, and molecular features of IDH-wildtype indolent diffuse glioma: comparison with typical glioblastoma. PMID:35779193
Lsm7 phase-separated condensates trigger stress granule formation. PMID:35764627
TCGA-My: A Systematic Repository for Systems Biology of Malaysian Colorectal Cancer. PMID:35743803
Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma. PMID:35705558
The drug-induced phenotypic landscape of colorectal cancer organoids. PMID:35668108
Differential Regulation of NK Cell Receptors in Acute Lymphoblastic Leukemia. PMID:35652109
In utero origin of myelofibrosis presenting in adult monozygotic twins. PMID:35637336
Targeting Cell Death Mechanism Specifically in Triple Negative Breast Cancer Cell Lines. PMID:35563174
Pathway-Based Analysis Revealed the Role of Keap1-Nrf2 Pathway and PI3K-Akt Pathway in Chinese Esophageal Squamous Cell Carcinoma Patients With Definitive Chemoradiotherapy. PMID:35548450
Clinical features and prognosis according to genomic mutations in primary and metastatic lesions of non-small-cell lung cancer. PMID:35466584
A general framework for predicting the transcriptomic consequences of non-coding variation and small molecules. PMID:35421087
Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma. PMID:35408839
A Custom DNA-Based NGS Panel for the Molecular Characterization of Patients With Diffuse Gliomas: Diagnostic and Therapeutic Applications. PMID:35372034
Robust In Vitro Pharmacology of Tmod, a Synthetic Dual-Signal Integrator for Cancer Cell Therapy. PMID:35359952
Focal p53 protein expression and lymphovascular invasion in primary prostate tumors predict metastatic progression. PMID:35354846
PIK3CA-AKT pathway predominantly acts in developing ipsilateral breast tumor recurrence long after breast-conserving surgery. PMID:35338411
Identification of Copy Number Alterations from Next-Generation Sequencing Data. PMID:35230683
Global profiling of phosphorylation-dependent changes in cysteine reactivity. PMID:35228727
Single-cell gene fusion detection by scFusion. PMID:35228538
The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization. PMID:35193494
Identifying Actionable Variants Using Capture-Based Targeted Sequencing in 563 Patients With Non-Small Cell Lung Carcinoma. PMID:35186718
Delineating the intra-patient heterogeneity of molecular alterations in treatment-naïve colorectal cancer with peritoneal carcinomatosis. PMID:35169225
Cancer as a Metabolic Disorder. PMID:35163079
Genome Nexus: A Comprehensive Resource for the Annotation and Interpretation of Genomic Variants in Cancer. PMID:35148171
Activating PIK3CA postzygotic mutations in segmental overgrowth of muscles with bone involvement in the body extremities. PMID:35122151
BRCA1/2 mutation spectrum in Chinese early-onset breast cancer. PMID:35116780
A narrative review of artificial intelligence-assisted histopathologic diagnosis and decision-making for non-small cell lung cancer: achievements and limitations. PMID:35070383
Exploiting protein family and protein network data to identify novel drug targets for bladder cancer. PMID:35035776
Prognostic biomarker SMARCC1 and its association with immune infiltrates in hepatocellular carcinoma. PMID:34937564
Bioinformatics analysis for the role of CALR in human cancers. PMID:34910788
Exploring the Prognostic Value, Immune Implication and Biological Function of H2AFY Gene in Hepatocellular Carcinoma. PMID:34899687
KRAS signaling in malignant pleural mesothelioma. PMID:34898002
Gene biomarker prediction in glioma by integrating scRNA-seq data and gene regulatory network. PMID:34863158
Identification of miR-499a-5p as a Potential Novel Biomarker for Risk Stratification in Endometrial Cancer. PMID:34804952
Super-Resolution Microscopy Reveals That Stromal Interaction Molecule 1 Trafficking Depends on Microtubule Dynamics. PMID:34803742
A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing. PMID:34764240
The role of zinc transporter proteins as predictive and prognostic biomarkers of hepatocellular cancer. PMID:34721988
miR-125a-5p promotes gastric cancer growth and invasion by regulating the Hippo pathway. PMID:34708891
Liquid Biopsy as a Diagnostic and Prognostic Tool for Women and Female Dogs with Breast Cancer. PMID:34680380
Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma. PMID:34649520
Conformational landscape of multidomain SMAD proteins. PMID:34630939
BRAF mutations may identify a clinically distinct subset of glioblastoma. PMID:34625582
A CIBERSORTx-based immune cell scoring system could independently predict the prognosis of patients with myelodysplastic syndromes. PMID:34614508
CPLM 4.0: an updated database with rich annotations for protein lysine modifications. PMID:34581824
Whole-Genome Profiles of Malay Colorectal Cancer Patients with Intact MMR Proteins. PMID:34573430
Identification of hub genes and functional modules in colon adenocarcinoma based on public databases by bioinformatics analysis. PMID:34532115
Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection. PMID:34530913
RNA-binding proteins of COSMIC importance in cancer. PMID:34523614
Carcinogen-induced DNA structural distortion differences in the RAS gene isoforms; the importance of local sequence. PMID:34521464
Proteogenomic analysis of pancreatic cancer subtypes. PMID:34506537
Mutational landscape of marginal zone B-cell lymphomas of various origin: organotypic alterations and diagnostic potential for assignment of organ origin. PMID:34494161
Therapeutic and prognostic insights from the analysis of cancer mutational signatures. PMID:34483003
Tilting MYC toward cancer cell death. PMID:34481764
Beta-Genus Human Papillomavirus 8 E6 Destabilizes the Host Genome by Promoting p300 Degradation. PMID:34452526
Chromoanagenesis Landscape in 10,000 TCGA Patients. PMID:34439350
Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex. PMID:34424918
EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis. PMID:34411095
Comparative analysis of nuclear and mitochondrial DNA from tissue and liquid biopsies of colorectal cancer patients. PMID:34408162
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation. PMID:34385319
Comprehensive Analysis of the Expression and Prognostic Value of SPINT1/2 in Breast Carcinoma. PMID:34381422
Reverting to single-cell biology: The predictions of the atavism theory of cancer. PMID:34371024
Definition of Biologically Distinct Groups of Conjunctival Melanomas According to Etiological Factors and Implications for Precision Medicine. PMID:34359736
Cloud Computing Based Immunopeptidomics Utilizing Community Curated Variant Libraries Simplifies and Improves Neo-Antigen Discovery in Metastatic Melanoma. PMID:34359654
A Comprehensive Pan-Cancer Analysis of RBM8A Based on Data Mining. PMID:34326876
Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis. PMID:34316699
Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression. PMID:34294073
Clinically Advanced Pheochromocytomas and Paragangliomas: A Comprehensive Genomic Profiling Study. PMID:34282751
RNA methylation in mammalian development and cancer. PMID:34272618
Comparative analysis of clonal evolution among patients with right- and left-sided colon and rectal cancer. PMID:34258553
A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases. PMID:34253785
The Functional Characterization of Epigenetically Related lncRNAs Involved in Dysregulated CeRNA-CeRNA Networks Across Eight Cancer Types. PMID:34222227
Molecular alterations in pancreatic tumors. PMID:34135550
Sequence Neighborhoods Enable Reliable Prediction of Pathogenic Mutations in Cancer Genomes. PMID:34068918
Identification of combinations of somatic mutations that predict cancer survival and immunotherapy benefit. PMID:34027407
A comprehensive review of m6A/m6Am RNA methyltransferase structures. PMID:34023900
An Integrated Genomic, Proteomic, and Immunopeptidomic Approach to Discover Treatment-Induced Neoantigens. PMID:33936100
On the Unfounded Enthusiasm for Soft Selective Sweeps III: The Supervised Machine Learning Algorithm That Isn't. PMID:33916341
Rapidly Growing and Aggressive Cutaneous Squamous Cell Carcinomas in a Patient Treated with Ruxolitinib. PMID:33911570
Pathogenic missense protein variants affect different functional pathways and proteomic features than healthy population variants. PMID:33909605
Whole-genome sequencing of phenotypically distinct inflammatory breast cancers reveals similar genomic alterations to non-inflammatory breast cancers. PMID:33902690
Genetic Mutation Analysis in Small Cell Lung Cancer by a Novel NGS-Based Targeted Resequencing Gene Panel and Relation with Clinical Features. PMID:33880365
MicroRNAs and angiogenesis: a new era for the management of colorectal cancer. PMID:33865381
Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription. PMID:33836152
Pancreas cancer: Therapeutic trials in metastatic disease. PMID:33831245
Light-Activation of DNA-Methyltransferases. PMID:33826797
Ubiquitination-mediated degradation of TRDMT1 regulates homologous recombination and therapeutic response. PMID:33778494
Kinetic Characterization of ASXL1/2-Mediated Allosteric Regulation of the BAP1 Deubiquitinase. PMID:33731362
Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing. PMID:33727697
A showcase study on personalized in silico drug response prediction based on the genetic landscape of muscle invasive bladder cancer. PMID:33712636
JNK signaling as a target for anticancer therapy. PMID:33710509
CoronaPep: An Anti-Coronavirus Peptide Generation Tool. PMID:33687847
Medication for Acromegaly Reduces Expression of MUC16, MACC1 and GRHL2 in Pituitary Neuroendocrine Tumour Tissue. PMID:33680922
Cervical malignant mixed mesonephric tumour: A case report with local recurrence after six-years and next-generation sequencing analysis with particular reference to the ataxia telangiectasia mutated gene. PMID:33680116
Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation. PMID:33674381
Different effects of p53 protein overexpression on the survival of gastric cancer patients according to Lauren histologic classification: a retrospective study. PMID:33598811
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. PMID:33568819
Molecular medicine tumor board: whole-genome sequencing to inform on personalized medicine for a man with advanced prostate cancer. PMID:33568750
Bisulfite-free epigenomics and genomics of single cells through methylation-sensitive restriction. PMID:33526904
Lead DEAD/H box helicase biomarkers with the therapeutic potential identified by integrated bioinformatic approaches in lung cancer. PMID:33425256
Comprehensive characterisation of intronic mis-splicing mutations in human cancers. PMID:33420369
Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences. PMID:33407744
Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer. PMID:33407715
Selective exosome exclusion of miR-375 by glioma cells promotes glioma progression by activating the CTGF-EGFR pathway. PMID:33407703
Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies. PMID:33398072
HER2 Status in High-Risk Endometrial Cancers (PORTEC-3): Relationship with Histotype, Molecular Classification, and Clinical Outcomes. PMID:33375706
Quantifying the influence of mutation detection on tumour subclonal reconstruction. PMID:33288765
Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance. PMID:33268819
Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups. PMID:33256706
Identification of synthetic chemosensitivity genes paired with BRAF for BRAF/MAPK inhibitors. PMID:33203961
Long Noncoding RNA LOC400043 (LINC02381) Inhibits Gastric Cancer Progression Through Regulating Wnt Signaling Pathway. PMID:33194632
Histone Variants: Guardians of Genome Integrity. PMID:33167489
Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis. PMID:33154497
BRAF Mutation in Colorectal Cancers: From Prognostic Marker to Targetable Mutation. PMID:33152998
Structural Insight on Functional Regulation of Human MINERVA Protein. PMID:33142954
BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling. PMID:33142801
circVAR database: genome-wide archive of genetic variants for human circular RNAs. PMID:33121433
A novel strategy for molecular interfaces optimization: The case of Ferritin-Transferrin receptor interaction. PMID:33101606
Genetic characterization of a case of sellar metastasis from bronchial carcinoid neuroendocrine tumor. PMID:33093980
Cetuximab-Mediated Protection from Hypoxia- Induced Cell Death: Implications for Therapy Sequence in Colorectal Cancer. PMID:33092032
The FGF/FGFR System in Breast Cancer: Oncogenic Features and Therapeutic Perspectives. PMID:33081025
Whole exome sequencing reveals pathogenic variants in MYO3A, MYO15A and COL9A3 and differential frequencies in ancestral alleles in hearing impairment genes among individuals from Cameroon. PMID:33078831
Droplet-digital PCR reveals frequent mutations in TERT promoter region in breast fibroadenomas and phyllodes tumours, irrespective of the presence of MED12 mutations. PMID:33046803
The construction of a lymphoma cell-based, DC-targeted vaccine, and its application in lymphoma prevention and cure. PMID:33005832
Transcriptomic characterization and innovative molecular classification of clear cell renal cell carcinoma in the Chinese population. PMID:32982583
RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer. PMID:32965059
Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma. PMID:32951278
Genetic profiling of primary and secondary tumors from patients with lung adenocarcinoma and bone metastases reveals targeted therapy options. PMID:32942985
Uncommon Site of Metastasis and Prolonged Survival in Patients with Anaplastic Thyroid Carcinoma: A Systematic Review of the Literature. PMID:32927794
The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome. PMID:32926574
Targetable BRAF and RAF1 Alterations in Advanced Pediatric Cancers. PMID:32918774
Personalized Clinical Decision Making Through Implementation of a Molecular Tumor Board: A German Single-Center Experience. PMID:32913998
Implementation and Clinical Utility of an Integrated Academic-Community Regional Molecular Tumor Board. PMID:32913980
Artificial Intelligence to Decode Cancer Mechanism: Beyond Patient Stratification for Precision Oncology. PMID:32903628
Identification of a novel subgroup of endometrial cancer patients with loss of thyroid hormone receptor beta expression and improved survival. PMID:32894083
Whole-exome mutational landscape of metastasis in patient-derived hepatocellular carcinoma cells. PMID:32884992
Pervasive chromosomal instability and karyotype order in tumour evolution. PMID:32879494
Progress in Neoantigen Targeted Cancer Immunotherapies. PMID:32850843
Organized immune cell interactions within tumors sustain a productive T-cell response. PMID:32827212
Features of increased malignancy in eosinophilic clear cell renal cell carcinoma. PMID:32815150
Metagenomic Studies in Inflammatory Skin Diseases. PMID:32813091
Clinical implications of prospective genomic profiling of metastatic breast cancer patients. PMID:32811538
Expanding cancer predisposition genes with ultra-rare cancer-exclusive human variations. PMID:32778766
Developing therapies for rare tumors: opportunities, challenges and progress. PMID:32765971
Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant. PMID:32756902
Sequential Whole Exome Sequencing Reveals Somatic Mutations Associated with Platinum Response in NSCLC. PMID:32753889
Distinct roles of structure-specific endonucleases EEPD1 and Metnase in replication stress responses. PMID:32743552
The roles of histone variants in fine-tuning chromatin organization and function. PMID:32665685
Collaborative, Multidisciplinary Evaluation of Cancer Variants Through Virtual Molecular Tumor Boards Informs Local Clinical Practices. PMID:32644817
The histone H3-H4 tetramer is a copper reductase enzyme. PMID:32631887
Metabolomic Markers of Colorectal Tumor With Different Clinicopathological Features. PMID:32626659
Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology. PMID:32614802
Targeted sequencing of FH-deficient uterine leiomyomas reveals biallelic inactivating somatic fumarase variants and allows characterization of missense variants. PMID:32612247
Nivolumab in Patients with Advanced Platinum-resistant Urothelial Carcinoma: Efficacy, Safety, and Biomarker Analyses with Extended Follow-up from CheckMate 275. PMID:32532789
Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma. PMID:32528726
Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes. PMID:32513296
Regulators of glucose uptake in thyroid cancer cell lines. PMID:32493394
Phase and context shape the function of composite oncogenic mutations. PMID:32461694
Integrative genomics approach identifies molecular features associated with early-stage ovarian carcinoma histotypes. PMID:32409713
Application of Multiplex Bisulfite PCR-Ligase Detection Reaction-Real-Time Quantitative PCR Assay in Interrogating Bioinformatically Identified, Blood-Based Methylation Markers for Colorectal Cancer. PMID:32407802
Quinacrine inhibits GSTA1 activity and induces apoptosis through G1/S arrest and generation of ROS in human non-small cell lung cancer cell lines. PMID:32405336
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. PMID:32393580
Comparative proteogenomics profiling of non-small and small lung carcinoma cell lines using mass spectrometry. PMID:32351780
Morphologic and genetic heterogeneity in breast fibroepithelial lesions-a comprehensive mapping study. PMID:32322022
New Treatment Strategies for Metastatic Pancreatic Ductal Adenocarcinoma. PMID:32306207
Convolutional neural network models for cancer type prediction based on gene expression. PMID:32241303
Somatic synonymous mutations in regulatory elements contribute to the genetic aetiology of melanoma. PMID:32241263
The Landscape of Somatic Copy Number Alterations in Head and Neck Squamous Cell Carcinoma. PMID:32226775
Molecular Signatures of Fusion Proteins in Cancer. PMID:32219217
Stabilization of Cyclin-Dependent Kinase 4 by Methionyl-tRNA Synthetase in p16INK4a-Negative Cancer. PMID:32219202
Salivary microRNA miR-let-7a-5p and miR-3928 could be used as potential diagnostic bio-markers for head and neck squamous cell carcinoma. PMID:32208417
Integrative Analysis of Siglec-15 mRNA in Human Cancers Based on Data Mining. PMID:32201516
FKBP4 is a malignant indicator in luminal A subtype of breast cancer. PMID:32194784
A decision tree to improve identification of pathogenic mutations in clinical practice. PMID:32151256
Mutations in the coat complex II component SEC23B promote colorectal cancer metastasis. PMID:32123160
XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary. PMID:32115573
Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers. PMID:32103169
Phosphotyrosine-based Phosphoproteomics for Target Identification and Drug Response Prediction in AML Cell Lines. PMID:32102969
Adopting solutions for annotation and reporting of next generation sequencing in clinical practice. PMID:32099889
Tumor suppressor genes and allele-specific expression: mechanisms and significance. PMID:32064050
RBP EIF2S2 Promotes Tumorigenesis and Progression by Regulating MYC-Mediated Inhibition via FHIT-Related Enhancers. PMID:32059763
SuperFreq: Integrated mutation detection and clonal tracking in cancer. PMID:32053599
Loss of phosphatase activity in PTEN (phosphatase and tensin homolog deleted on chromosome ten) results in endometrial carcinoma in humans: An in-silico study. PMID:32042934
A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells. PMID:32039742
Impact of accumulated alterations in driver and passenger genes on response to radiation therapy. PMID:32031414
Combined burden and functional impact tests for cancer driver discovery using DriverPower. PMID:32024818
Identification of cancer driver genes based on nucleotide context. PMID:32015527
CANCERSIGN: a user-friendly and robust tool for identification and classification of mutational signatures and patterns in cancer genomes. PMID:31992766
Deep neural networks for interpreting RNA-binding protein target preferences. PMID:31992613
Mutation Enrichment and Transcriptomic Activation Signatures of 419 Molecular Pathways in Cancer. PMID:31979117
Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival. PMID:31969654
Identification of osteosarcoma driver genes using a network method. PMID:31966051
An Exon Signature to Estimate the Tumor Mutational Burden of Right-sided Colon Cancer Patients. PMID:31949492
Comprehensive identification and characterization of somatic copy number alterations in triple‑negative breast cancer. PMID:31894314
The exploration of disease-specific gene regulatory networks in esophageal carcinoma and stomach adenocarcinoma. PMID:31888440
Patient-Derived Cells to Guide Targeted Therapy for Advanced Lung Adenocarcinoma. PMID:31882684
The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer. PMID:31880305
Membrane Anchoring of Hck Kinase via the Intrinsically Disordered SH4-U and Length Scale Associated with Subcellular Localization. PMID:31877324
Oncogenic Mutations in Armadillo Repeats 5 and 6 of β-Catenin Reduce Binding to APC, Increasing Signaling and Transcription of Target Genes. PMID:31857074
Systematic expression analysis of WEE family kinases reveals the importance of PKMYT1 in breast carcinogenesis. PMID:31837068
Clinico-neuropathological features of isocitrate dehydrogenase 2 gene mutations in lower-grade gliomas. PMID:31833906
Clinicopathological and molecular characterisation of 'multiple-classifier' endometrial carcinomas. PMID:31829447
A Molecular Epidemiological Analysis Of Programmed Cell Death Ligand-1 (PD-L1) Protein Expression, Mutations And Survival In Non-Small Cell Lung Cancer. PMID:31819612
An analysis of mutational signatures of synonymous mutations across 15 cancer types. PMID:31815613
Embryonal precursors of Wilms tumor. PMID:31806814
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID. PMID:31804490
Text-mining clinically relevant cancer biomarkers for curation into the CIViC database. PMID:31796060
Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma. PMID:31792460
CBNA: A control theory based method for identifying coding and non-coding cancer drivers. PMID:31790386
Tumor Mutational Burden and Genomic Alterations in Chinese Small Cell Lung Cancer Measured by Whole-Exome Sequencing. PMID:31781628
Germline and somatic mutations of homologous recombination-associated genes in Japanese ovarian cancer patients. PMID:31780705
Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study. PMID:31741715
Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations. PMID:31740029
CPEM: Accurate cancer type classification based on somatic alterations using an ensemble of a random forest and a deep neural network. PMID:31729414
The OncoLifeS data-biobank for oncology: a comprehensive repository of clinical data, biological samples, and the patient's perspective. PMID:31727094
Biomarker identification of hepatocellular carcinoma using a methodical literature mining strategy. PMID:31725857
Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia. PMID:31697823
TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP), A Novel Therapeutic Target Of Breast Cancer. PMID:31695491
Comprehensive analysis of POLE and POLD1 Gene Variations identifies cancer patients potentially benefit from immunotherapy in Chinese population. PMID:31673068
Mutations of RAS genes in endometrial polyps. PMID:31638232
Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers. PMID:31637211
ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy. PMID:31636955
Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome. PMID:31624251
A Complex Interplay of Anionic Phospholipid Binding Regulates 3'-Phosphoinositide-Dependent-Kinase-1 Homodimer Activation. PMID:31601855
Nonlinear mixed-effects models for modeling in vitro drug response data to determine problematic cancer cell lines. PMID:31594982
Recent advances and emerging therapies in anaplastic thyroid carcinoma. PMID:31583077
Common Secondary Genomic Variants Associated With Advanced Epithelioid Hemangioendothelioma. PMID:31577358
Pathway Mutations in Breast Cancer Using Whole-Exome Sequencing. PMID:31575382
Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. PMID:31570656
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials. PMID:31511426
Predicting links between tumor samples and genes using 2-Layered graph based diffusion approach. PMID:31500564
Opportunities for new studies of nuclear DNA replication enzymology in budding yeast. PMID:31493018
Discordant Effects of Putative Lysine Acetyltransferase Inhibitors in Biochemical and Living Systems. PMID:31480793
Leveraging protein dynamics to identify cancer mutational hotspots using 3D structures. PMID:31462496
Neoantigen vaccine: an emerging tumor immunotherapy. PMID:31443694
Distinct signatures of lung cancer types: aberrant mucin O-glycosylation and compromised immune response. PMID:31429720
Oncogenic G12D mutation alters local conformations and dynamics of K-Ras. PMID:31409810
Genetic Interaction-Based Biomarkers Identification for Drug Resistance and Sensitivity in Cancer Cells. PMID:31400611
Mutational processes contributing to the development of multiple myeloma. PMID:31387987
Prognostic relevance of ATM protein in uveal melanoma and its association with clinicopathological factors. PMID:31377937
Somatic evolution and global expansion of an ancient transmissible cancer lineage. PMID:31371581
Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing. PMID:31360895
Structural basis of the atypical activation mechanism of KRASV14I. PMID:31341022
Targeted Therapy for Advanced Thyroid Cancer: Kinase Inhibitors and Beyond. PMID:31322645
Genomics-Guided Immunotherapy for Precision Medicine in Cancer. PMID:31314580
Improved detection of gene fusions by applying statistical methods reveals oncogenic RNA cancer drivers. PMID:31308241
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome. PMID:31303423
Comparative proteogenomic characterization of glioblastoma. PMID:31290679
Urinary expression of genes involved in DNA methylation and histone modification for diagnosis of bladder cancer in patients with asymptomatic microscopic haematuria. PMID:31289472
Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research. PMID:31287543
Genetic interactions of G-quadruplexes in humans. PMID:31287417
Single-cell RNA-seq variant analysis for exploration of genetic heterogeneity in cancer. PMID:31267007
Recurrent DMD Deletions Highlight Specific Role of Dp71 Isoform in Soft-Tissue Sarcomas. PMID:31266185
FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding. PMID:31262713
Comprehensive genomic profiling of recurrent endometrial cancer: Implications for selection of systemic therapy. PMID:31257009
Detection of mutational patterns in cell-free DNA of colorectal cancer by custom amplicon sequencing. PMID:31254442
The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs. PMID:31253656
FGFR2-Altered Gastroesophageal Adenocarcinomas Are an Uncommon Clinicopathologic Entity with a Distinct Genomic Landscape. PMID:31249137
Integration of Random Forest Classifiers and Deep Convolutional Neural Networks for Classification and Biomolecular Modeling of Cancer Driver Mutations. PMID:31245384
Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas. PMID:31231471
In-silico Prediction of Synergistic Anti-Cancer Drug Combinations Using Multi-omics Data. PMID:31222109
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen. PMID:31209238
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues. PMID:31171663
Integrative Analysis of Somatic Mutations in Non-coding Regions Altering RNA Secondary Structures in Cancer Genomes. PMID:31160636
Mutational burden and signatures in 4000 Japanese cancers provide insights into tumorigenesis and response to therapy. PMID:31152682
Lipid-dependent Akt-ivity: where, when, and how. PMID:31147387
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma. PMID:31131257
Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma. PMID:31112524
Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi. PMID:31111470
Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children. PMID:31102422
GIDB: a knowledge database for the automated curation and multidimensional analysis of molecular signatures in gastrointestinal cancer. PMID:31089686
Return to the Sea, Get Huge, Beat Cancer: An Analysis of Cetacean Genomes Including an Assembly for the Humpback Whale (Megaptera novaeangliae). PMID:31070747
Comprehensive genomic and prognostic analysis of the IL‑17 family genes in lung cancer. PMID:31059089
Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation. PMID:31048683
Genetics of testicular germ cell tumors. PMID:31045925
HumCFS: a database of fragile sites in human chromosomes. PMID:30999860
Discovering novel mutation signatures by latent Dirichlet allocation with variational Bayes inference. PMID:30993319
Molecular carcinogenesis of gastric cancer: Lauren classification, mucin phenotype expression, and cancer stem cells. PMID:30980196
The Molecular Organization of Human cGMP Specific Phosphodiesterase 6 (PDE6): Structural Implications of Somatic Mutations in Cancer and Retinitis Pigmentosa. PMID:30962868
TagGraph reveals vast protein modification landscapes from large tandem mass spectrometry datasets. PMID:30936560
Investigation of somatic single nucleotide variations in human endogenous retrovirus elements and their potential association with cancer. PMID:30934003
SNP mutation-related genes in breast cancer for monitoring and prognosis of patients: A study based on the TCGA database. PMID:30883028
Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction. PMID:30880007
Ancestral characterization of 1018 cancer cell lines highlights disparities and reveals gene expression and mutational differences. PMID:30865299
Haplotype-resolved and integrated genome analysis of the cancer cell line HepG2. PMID:30864654
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition. PMID:30860482
Overexpression of FZD1 is Associated with a Good Prognosis and Resistance of Sunitinib in Clear Cell Renal Cell Carcinoma. PMID:30854133
Clinical relevance of circulating molecules in cancer: focus on gastrointestinal stromal tumors. PMID:30854029
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil. PMID:30838409
Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors. PMID:30835255
Post-neoadjuvant treatment and the management of residual disease in breast cancer: state of the art and perspectives. PMID:30833989
Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors. PMID:30823893
Bidirectional modulation of HIF-2 activity through chemical ligands. PMID:30804532
Genomic landscape of a metastatic malignant proliferating tricholemmal tumor and its response to PI3K inhibition. PMID:30793038
Prediction of response to anti-cancer drugs becomes robust via network integration of molecular data. PMID:30787419
Molecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma. PMID:30761385
Nucleotide Weight Matrices Reveal Ubiquitous Mutational Footprints of AID/APOBEC Deaminases in Human Cancer Genomes. PMID:30759888
CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3. PMID:30755730
Signals of Variation in Human Mutation Rate at Multiple Levels of Sequence Context. PMID:30753705
tRNA modification and cancer: potential for therapeutic prevention and intervention. PMID:30744422
Non-Smoking-Associated Lung Cancer: A distinct Entity in Terms of Tumor Biology, Patient Characteristics and Impact of Hereditary Cancer Predisposition. PMID:30744199
VARIFI-Web-Based Automatic Variant Identification, Filtering and Annotation of Amplicon Sequencing Data. PMID:30717290
Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients. PMID:30709382
Potential involvement of RITA in the activation of Aurora A at spindle poles during mitosis. PMID:30705408
Comparison of different functional prediction scores using a gene-based permutation model for identifying cancer driver genes. PMID:30704472
One tool to find them all: a case of data integration and querying in a distributed LIMS platform. PMID:30698777
Inhibition of EZH2 induces NK cell-mediated differentiation and death in muscle-invasive bladder cancer. PMID:30692641
An essential role for dNTP homeostasis following CDK-induced replication stress. PMID:30674555
A CATH domain functional family based approach to identify putative cancer driver genes and driver mutations. PMID:30670742
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme. PMID:30670691
Challenges in Stratifying the Molecular Variability of Patient-Derived Colon Tumor Xenografts. PMID:30662905
Pathway Instability Is an Effective New Mutation-Based Type of Cancer Biomarkers. PMID:30662873
Bottom-up, integrated -omics analysis identifies broadly dosage-sensitive genes in breast cancer samples from TCGA. PMID:30653567
PANOPLY: Omics-Guided Drug Prioritization Method Tailored to an Individual Patient. PMID:30652605
Cancer therapeutic targeting using mutant-p53-specific siRNAs. PMID:30643191
RCBTB1 Deletion Is Associated with Metastatic Outcome and Contributes to Docetaxel Resistance in Nontranslocation-Related Pleomorphic Sarcomas. PMID:30641971
Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. PMID:30641053
Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage. PMID:30633903
Whole genomes define concordance of matched primary, xenograft, and organoid models of pancreas cancer. PMID:30629588
Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set. PMID:30602777
Decoding Somatic Driver Gene Mutations and Affected Signaling Pathways in Human Medulloblastoma Subgroups. PMID:30588243
Ensembl variation resources. PMID:30576484
Novel circular RNA circNF1 acts as a molecular sponge, promoting gastric cancer by absorbing miR-16. PMID:30576282
Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health. PMID:30545954
Knowledge base toward understanding actionable alterations and realizing precision oncology. PMID:30542800
A multi-omics approach for identifying important pathways and genes in human cancer. PMID:30541428
A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease. PMID:30541027
Natural products as new antimitotic compounds for anticancer drug development. PMID:30540125
Overexpressed PLAGL2 transcriptionally activates Wnt6 and promotes cancer development in colorectal cancer. PMID:30535429
A mechanistic classification of clinical phenotypes in neuroblastoma. PMID:30523111
Next-generation sequencing-based clinical sequencing: toward precision medicine in solid tumors. PMID:30515675
FAM129B promoted tumor invasion and proliferation via facilitating the phosphorylation of FAK signaling and associated with adverse clinical outcome of non-small cell lung cancer patients. PMID:30498362
S-phase cancer associated lncRNAs. PMID:30482083
Evaluating Clinical Genome Sequence Analysis by Watson for Genomics. PMID:30474028
Variant information systems for precision oncology. PMID:30463544
Mutational Evolution in Relapsed Diffuse Large B-Cell Lymphoma. PMID:30463380
A comparative analysis of KMT2D missense variants in Kabuki syndrome, cancers and the general population. PMID:30459467
Quantification of somatic mutation flow across individual cell division events by lineage sequencing. PMID:30459213
Loss of function of NF1 is a mechanism of acquired resistance to endocrine therapy in lobular breast cancer. PMID:30423024
Transcriptomic and genomic profiling of early-stage ovarian carcinomas associated with histotype and overall survival. PMID:30416686
Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations. PMID:30412573
Unique divergence of the breast cancer 2 (BRCA2) gene in Neanderthals. PMID:30410429
Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma. PMID:30405107
A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes. PMID:30400878
Disordered Regions of Mixed Lineage Leukemia 4 (MLL4) Protein Are Capable of RNA Binding. PMID:30400675
Hydroxysteroid 11-Beta Dehydrogenase 1 Overexpression with Copy-Number Gain and Missense Mutations in Primary Gastrointestinal Stromal Tumors. PMID:30388854
Correlation of Platinum Cytotoxicity to Drug-DNA Adduct Levels in a Breast Cancer Cell Line Panel. PMID:30381944
Network integration of multi-tumour omics data suggests novel targeting strategies. PMID:30375513
Genomic Profiling of Parathyroid Carcinoma Reveals Genomic Alterations Suggesting Benefit from Therapy. PMID:30373905
SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics. PMID:30373609
Non-coding genetic variation in cancer. PMID:30370373
Cancer type prediction based on copy number aberration and chromatin 3D structure with convolutional neural networks. PMID:30367576
Effect Sizes of Somatic Mutations in Cancer. PMID:30365005
Aberrant splicing in B-cell acute lymphoblastic leukemia. PMID:30357359
Analysis of impact metrics for the Protein Data Bank. PMID:30325351
β-Catenin is a pH sensor with decreased stability at higher intracellular pH. PMID:30315137
ClinGen Allele Registry links information about genetic variants. PMID:30311374
PHLI-seq: constructing and visualizing cancer genomic maps in 3D by phenotype-based high-throughput laser-aided isolation and sequencing. PMID:30296938
XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data. PMID:30286710
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. PMID:30275568
POFUT1 promotes colorectal cancer development through the activation of Notch1 signaling. PMID:30250219
Inference of Germline Mutational Status and Evaluation of Loss of Heterozygosity in High-Depth, Tumor-Only Sequencing Data. PMID:30246169
A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation. PMID:30238850
Exome scale map of genetic alterations promoting metastasis in colorectal cancer. PMID:30231850
Clinical molecular testing for ASXL1 c.1934dupG p.Gly646fs mutation in hematologic neoplasms in the NGS era. PMID:30222780
Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer. PMID:30209039
Integrative detection and analysis of structural variation in cancer genomes. PMID:30202056
Next-generation sequencing and personalized genomic medicine in hepatobiliary malignancies. PMID:30191018
Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis. PMID:30188888
A machine learning approach for somatic mutation discovery. PMID:30185652
Structural insights into the functional diversity of the CDK-cyclin family. PMID:30185601
Precision Lasso: accounting for correlations and linear dependencies in high-dimensional genomic data. PMID:30184048
Somatic genome alterations in relation to age in lung squamous cell carcinoma. PMID:30181806
SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis. PMID:30177679
Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours. PMID:30176945
The Ras-related gene ERAS is involved in human and murine breast cancer. PMID:30158566
The germline genetic component of drug sensitivity in cancer cell lines. PMID:30139972
p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2. PMID:30126895
Detection of Molecular Alterations in Taiwanese Patients with Medullary Thyroid Cancer Using Whole-Exome Sequencing. PMID:30120715
Systems level expression correlation of Ras GTPase regulators. PMID:30111366
Comprehensive Genomic Profiling of Hodgkin Lymphoma Reveals Recurrently Mutated Genes and Increased Mutation Burden. PMID:30108156
Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer. PMID:30108113
Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma. PMID:30093633
Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases. PMID:30087384
Detection and benchmarking of somatic mutations in cancer genomes using RNA-seq data. PMID:30083469
Pan-Cancer Analysis Reveals Differential Susceptibility of Bidirectional Gene Promoters to DNA Methylation, Somatic Mutations, and Copy Number Alterations. PMID:30081598
Elucidating therapeutic molecular targets in premenopausal Asian women with recurrent breast cancers. PMID:30062102
Explaining cancer type specific mutations with transcriptomic and epigenomic features in normal tissues. PMID:30061703
Expressed HNSCC variants by HPV-status in a well-characterized Michigan cohort. PMID:30061624
BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery. PMID:30053270
Analysis of public RNA-sequencing data reveals biological consequences of genetic heterogeneity in cell line populations. PMID:30046134
Insights into the Mutational Burden of Human Induced Pluripotent Stem Cells from an Integrative Multi-Omics Approach. PMID:30044985
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma. PMID:30030436
Integrative landscape of dysregulated signaling pathways of clinically distinct pancreatic cancer subtypes. PMID:30018740
Machine Learning for Better Prognostic Stratification and Driver Gene Identification Using Somatic Copy Number Variations in Anaplastic Oligodendroglioma. PMID:30018130
Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population. PMID:30012096
Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae. PMID:30011030
Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling. PMID:30007540
Structure and energy based quantitative missense variant effect analysis provides insights into drug resistance mechanisms of anaplastic lymphoma kinase mutations. PMID:30006516
Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations. PMID:30006355
Recurrent tumor-specific regulation of alternative polyadenylation of cancer-related genes. PMID:30005633
Radio-sensitizing effects of VE-821 and beyond: Distinct phosphoproteomic and metabolomic changes after ATR inhibition in irradiated MOLT-4 cells. PMID:30001349
Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket. PMID:29997876
Salvage pembrolizumab added to kinase inhibitor therapy for the treatment of anaplastic thyroid carcinoma. PMID:29996921
Prioritization and functional assessment of noncoding variants associated with complex diseases. PMID:29996888
Patterns of genomic evolution in advanced melanoma. PMID:29991680
Personalized regression enables sample-specific pan-cancer analysis. PMID:29949997
Improving genomics-based predictions for precision medicine through active elicitation of expert knowledge. PMID:29949984
Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update. PMID:29949919
appreci8: a pipeline for precise variant calling integrating 8 tools. PMID:29945233
ncdDetect2: improved models of the site-specific mutation rate in cancer and driver detection with robust significance evaluation. PMID:29945188
DeTiN: overcoming tumor-in-normal contamination. PMID:29941871
Integrated multi-omics data analysis identifying novel drug sensitivity-associated molecular targets of hepatocellular carcinoma cells. PMID:29930714
Molecular Characterization and Putative Pathogenic Pathways of Tuberous Sclerosis Complex-Associated Renal Cell Carcinoma. PMID:29925043
A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas. PMID:29915258
Plasmatic membrane toll-like receptor expressions in human astrocytomas. PMID:29912993
Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged 75 years or older. PMID:29903761
Association of ERBB Mutations With Clinical Outcomes of Afatinib- or Erlotinib-Treated Patients With Lung Squamous Cell Carcinoma: Secondary Analysis of the LUX-Lung 8 Randomized Clinical Trial. PMID:29902295
Principled multi-omic analysis reveals gene regulatory mechanisms of phenotype variation. PMID:29898900
Cancer-mutation network and the number and specificity of driver mutations. PMID:29895694
Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations. PMID:29880869
Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies. PMID:29880484
Changing Trends in Computational Drug Repositioning. PMID:29874824
Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma. PMID:29872726
Lung Cancer: One Disease or Many. PMID:29864749
Analysis of mutation, selection, and epistasis: an informed approach to cancer clinical trials. PMID:29854275
Efficacy of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Inhibitor, in Patients with Previously Treated Advanced Urothelial Carcinoma with FGFR3 Alterations. PMID:29848605
CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma. PMID:29804288
Systematic pan-cancer analysis of somatic allele frequency. PMID:29769535
Cancer subtype identification using somatic mutation data. PMID:29765148
VAReporter: variant reporter for cancer research of massive parallel sequencing. PMID:29764369
Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors. PMID:29760383
RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage. PMID:29742442
A genome-wide survey of mutations in the Jurkat cell line. PMID:29739316
Effect of RAD51C expression on the chemosensitivity of Eμ-Myc p19Arf-/- cells and its clinical significance in breast cancer. PMID:29731842
Development of Preclinical Models to Understand and Treat Colorectal Cancer. PMID:29720906
De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia. PMID:29720585
Pathway-based dissection of the genomic heterogeneity of cancer hallmarks' acquisition with SLAPenrich. PMID:29713020
Oncolytic activity of the rhabdovirus VSV-GP against prostate cancer. PMID:29696636
Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources. PMID:29695735
dbDEPC 3.0: the database of differentially expressed proteins in human cancer with multi-level annotation and drug indication. PMID:29688359
CellExpress: a comprehensive microarray-based cancer cell line and clinical sample gene expression analysis online system. PMID:29688349
Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma. PMID:29686388
Subunit-Specific Role of NF-κB in Cancer. PMID:29673141
Modeling and correct the GC bias of tumor and normal WGS data for SCNA based tumor subclonal population inferring. PMID:29671389
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets. PMID:29662167
NIPS, a 3D network-integrated predictor of deleterious protein SAPs, and its application in cancer prognosis. PMID:29662108
Helicase-like transcription factor expression is associated with a poor prognosis in Non-Small-Cell Lung Cancer (NSCLC). PMID:29661164
oncoNcRNA: A Web Portal for Exploring the Non-Coding RNAs with Oncogenic Potentials in Human Cancers. PMID:29657279
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal. PMID:29656891
Whole-genome sequencing of multiple myeloma reveals oncogenic pathways are targeted somatically through multiple mechanisms. PMID:29654271
Functional domain analysis of SOX18 transcription factor using a single-chain variable fragment-based approach. PMID:29648920
Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients. PMID:29636477
The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils. PMID:29634948
Epigenetic alterations to Polycomb targets precede malignant transition in a mouse model of breast cancer. PMID:29615825
Finding cancer driver mutations in the era of big data research. PMID:29611034
FGFR1 tyrosine kinase domain duplication in pilocytic astrocytoma with anaplasia. PMID:29610389
Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines. PMID:29596782
Dissecting the Mutational Landscape of Cutaneous Melanoma: An Omic Analysis Based on Patients from Greece. PMID:29596374
Genetic Evidence for Early Peritoneal Spreading in Pelvic High-Grade Serous Cancer. PMID:29594039
Methylation-to-Expression Feature Models of Breast Cancer Accurately Predict Overall Survival, Distant-Recurrence Free Survival, and Pathologic Complete Response in Multiple Cohorts. PMID:29581450
Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers. PMID:29575536
A single digital droplet PCR assay to detect multiple KIT exon 11 mutations in tumor and plasma from patients with gastrointestinal stromal tumors. PMID:29568401
Identification of potential regulatory mutations using multi-omics analysis and haplotyping of lung adenocarcinoma cell lines. PMID:29563587
A multiple myeloma-specific capture sequencing platform discovers novel translocations and frequent, risk-associated point mutations in IGLL5. PMID:29563506
RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia. PMID:29563491
New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response. PMID:29562639
An integrative bioinformatics approach reveals coding and non-coding gene variants associated with gene expression profiles and outcome in breast cancer molecular subtypes. PMID:29559730
High-throughput sequencing of nodal marginal zone lymphomas identifies recurrent BRAF mutations. PMID:29556019
Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells. PMID:29541393
Prevalence of the single-nucleotide polymorphism rs11554137 (IDH1105GGT) in brain tumors of a cohort of Italian patients. PMID:29535392
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors. PMID:29535388
Global analysis of A-to-I RNA editing reveals association with common disease variants. PMID:29527417
A High-Throughput Mutational Scan of an Intrinsically Disordered Acidic Transcriptional Activation Domain. PMID:29525204
Molecular Response to Neoadjuvant Chemotherapy in High-Grade Serous Ovarian Carcinoma. PMID:29523763
Efficacy of histology-agnostic and molecularly-driven HER2 inhibitors for refractory cancers. PMID:29515767
Hereditary cancer genes are highly susceptible to splicing mutations. PMID:29505604
PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers. PMID:29491376
The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection. PMID:29487696
A NOVEL AND EFFICIENT ALGORITHM FOR DE NOVO DISCOVERY OF MUTATED DRIVER PATHWAYS IN CANCER. PMID:29479394
Combinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response. PMID:29472726
Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia. PMID:29472724
Olaparib is effective in combination with, and as maintenance therapy after, first-line endocrine therapy in prostate cancer cells. PMID:29465803
Comprehensive Analysis of Constraint on the Spatial Distribution of Missense Variants in Human Protein Structures. PMID:29455857
Macrogenomic engineering via modulation of the scaling of chromatin packing density. PMID:29450107
STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion. PMID:29438108
Mutational signatures and chromosome alteration profiles of squamous cell carcinomas of the vulva. PMID:29422544
Structural basis for DNMT3A-mediated de novo DNA methylation. PMID:29414941
IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome. PMID:29390075
Reviewing the Utility of EUS FNA to Advance Precision Medicine in Pancreatic Cancer. PMID:29382047
Deep learning of mutation-gene-drug relations from the literature. PMID:29368597
Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production. PMID:29367762
Somatic APC mosaicism and oligogenic inheritance in genetically unsolved colorectal adenomatous polyposis patients. PMID:29367705
Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions. PMID:29358619
Interactome INSIDER: a structural interactome browser for genomic studies. PMID:29355848
A robust targeted sequencing approach for low input and variable quality DNA from clinical samples. PMID:29354287
Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival. PMID:29354286
Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae. PMID:29352080
Somatic evolutionary timings of driver mutations. PMID:29347918
Whole genome sequencing analysis for cancer genomics and precision medicine. PMID:29345757
Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. PMID:29345617
Cancer vaccine: learning lessons from immune checkpoint inhibitors. PMID:29344272
An orthotopic mouse model of gastric cancer invasion and metastasis. PMID:29339747
Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3. PMID:29338072
Characterizing genomic differences of human cancer stratified by the TP53 mutation status. PMID:29330617
Human Placental-Derived Adherent Stromal Cells Co-Induced with TNF-α and IFN-γ Inhibit Triple-Negative Breast Cancer in Nude Mouse Xenograft Models. PMID:29330447
An Rb family-independent E2F3 transcription factor variant impairs STAT5 signaling and mammary gland remodeling during pregnancy in mice. PMID:29330306
Genomic heterogeneity of ALK fusion breakpoints in non-small-cell lung cancer. PMID:29327716
Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix. PMID:29327707
Effects of trastuzumab and afatinib on kinase activity in gastric cancer cell lines. PMID:29325228
Allele-specific SHAPE-MaP assessment of the effects of somatic variation and protein binding on mRNA structure. PMID:29317542
Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family. PMID:29309642
Three-Dimensional Cellular Arrangement in Epithelial Ovarian Cancer Cell Lines TOV-21G and SKOV-3 is Associated with Apoptosis-Related miRNA Expression Modulation. PMID:29307001
Mutations in EMT-Related Genes in ALK Positive Crizotinib Resistant Non-Small Cell Lung Cancers. PMID:29300322
Mutation status coupled with RNA-sequencing data can efficiently identify important non-significantly mutated genes serving as diagnostic biomarkers of endometrial cancer. PMID:29297280
High-throughput sequencing of the B-cell receptor in African Burkitt lymphoma reveals clues to pathogenesis. PMID:29296973
Index case of acute myeloid leukemia in a family harboring a novel CEBPA germ line mutation. PMID:29296967
Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations. PMID:29295717
Functional characterization of a novel somatic oncogenic mutation of PIK3CB. PMID:29279775
Bioinformatic Analysis of Circadian Expression of Oncogenes and Tumor Suppressor Genes. PMID:29276378
Bioinformatics for precision oncology. PMID:29272324
Identification of potentially oncogenic alterations from tumor-only samples reveals Fanconi anemia pathway mutations in bladder carcinomas. PMID:29263839
Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma. PMID:29263824
The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy. PMID:29259203
Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer. PMID:29259186
Development and validation of a targeted next generation DNA sequencing panel outperforming whole exome sequencing for the identification of clinically relevant genetic variants. PMID:29254223
Informatics for cancer immunotherapy. PMID:29253114
Direct inhibition of RAS: Quest for the Holy Grail? PMID:29248537
Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum. PMID:29245897
Interleukin-4 induces a CD44high /CD49bhigh PC3 subpopulation with tumor-initiating characteristics. PMID:29236307
Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity. PMID:29233960
Causal somatic mutations in urine DNA from persons with the CLOVES subgroup of the PIK3CA-related overgrowth spectrum. PMID:29231959
Identification of cancer genes that are independent of dominant proliferation and lineage programs. PMID:29229826
Complete motif analysis of sequence requirements for translation initiation at non-AUG start codons. PMID:29228265
Pockets as structural descriptors of EGFR kinase conformations. PMID:29228029
Proteogenomic analysis prioritises functional single nucleotide variants in cancer samples. PMID:29221171
Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer. PMID:29216518
A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. PMID:29212479
Matrix metalloproteinase-1 expression in breast carcinoma: a marker for unfavorable prognosis. PMID:29207651
Genomic profiles of a hepatoblastoma from a patient with Beckwith-Wiedemann syndrome with uniparental disomy on chromosome 11p15 and germline mutation of APC and PALB2. PMID:29190888
High-throughput full-length single-cell mRNA-seq of rare cells. PMID:29186152
Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. PMID:29183403
Predicting cancer type from tumour DNA signatures. PMID:29183400
Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations. PMID:29180611
Functional germline variants as potential co-oncogenes. PMID:29177190
Promoter Hypermethylation of the ATM Gene as a Novel Biomarker for Breast Cancer. PMID:29172272
Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy. PMID:29163793
Nonmonotonic Pathway Gene Expression Analysis Reveals Oncogenic Role of p27/Kip1 at Intermediate Dose. PMID:29162974
Real-World Experience with Targeted Therapy for the Treatment of Anaplastic Thyroid Carcinoma. PMID:29161986
THANATOS: an integrative data resource of proteins and post-translational modifications in the regulation of autophagy. PMID:29157087
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines. PMID:29156801
Catching hidden variation: systematic correction of reference minor allele annotation in clinical variant calling. PMID:29155419
mSignatureDB: a database for deciphering mutational signatures in human cancers. PMID:29145625
Spontaneous development of Epstein-Barr Virus associated human lymphomas in a prostate cancer xenograft program. PMID:29145505
Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer. PMID:29138515
The Rho GTPase signalling pathway in urothelial carcinoma. PMID:29133936
Human primary liver cancer-derived organoid cultures for disease modeling and drug screening. PMID:29131160
Tumor molecular profiling of NSCLC patients using next generation sequencing. PMID:29130105
The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export. PMID:29112714
Passage-dependent accumulation of somatic mutations in mesenchymal stromal cells during in vitro culture revealed by whole genome sequencing. PMID:29109420
PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer. PMID:29108454
Size-based detection of sarcoma circulating tumor cells and cell clusters. PMID:29108279
MHC-I Genotype Restricts the Oncogenic Mutational Landscape. PMID:29107334
ASpedia: a comprehensive encyclopedia of human alternative splicing. PMID:29106599
Activation-induced cytidine deaminase prevents pro-B cell acute lymphoblastic leukemia by functioning as a negative regulator in Rag1 deficient pro-B cells. PMID:29100269
TumorFusions: an integrative resource for cancer-associated transcript fusions. PMID:29099951
Combating subclonal evolution of resistant cancer phenotypes. PMID:29093439
Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing. PMID:29092957
CRAVAT 4: Cancer-Related Analysis of Variants Toolkit. PMID:29092935
TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules. PMID:29088312
Pharmacological inhibition of the transcription factor PU.1 in leukemia. PMID:29083320
Somatic mutation driven codon transition bias in human cancer. PMID:29079855
PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival. PMID:29078751
UPS-indel: a Universal Positioning System for Indels. PMID:29074871
Mutation analysis and copy number alterations of KIF23 in non-small-cell lung cancer exhibiting KIF23 over-expression. PMID:29066916
QuaDMutEx: quadratic driver mutation explorer. PMID:29065872
Mutations in RNA methylating enzymes in disease. PMID:29059606
Cancer Prevention and Treatment by Wholistic Nutrition. PMID:29057328
Universal Patterns of Selection in Cancer and Somatic Tissues. PMID:29056346
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. PMID:29050219
Revealing the Determinants of Widespread Alternative Splicing Perturbation in Cancer. PMID:29045845
Comprehensive benchmarking of SNV callers for highly admixed tumor data. PMID:29020110
Nanotechnology as a Delivery Tool for Precision Cancer Therapies. PMID:29019032
How activating mutations affect MEK1 regulation and function. PMID:29018093
Tissue specificity of in vitro drug sensitivity. PMID:29016819
Vertical inhibition of the PI3K/Akt/mTOR pathway is synergistic in breast cancer. PMID:28991258
Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma. PMID:28984303
Frequent miRNA-convergent fusion gene events in breast cancer. PMID:28983113
Distinct distributions of genomic features of the 5' and 3' partners of coding somatic cancer gene fusions: arising mechanisms and functional implications. PMID:28977995
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas. PMID:28974674
RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia. PMID:28972594
Functional Impact of Chromatin Remodeling Gene Mutations and Predictive Signature for Therapeutic Response in Bladder Cancer. PMID:28970362
Learning causal networks with latent variables from multivariate information in genomic data. PMID:28968390
Comprehensive genomic profiles of metastatic and relapsed salivary gland carcinomas are associated with tumor type and reveal new routes to targeted therapies. PMID:28961851
GAB2 Amplification in Squamous Cell Lung Cancer of Non-Smokers. PMID:28960030
Molecular subtype specific efficacy of MEK inhibitors in pancreatic cancers. PMID:28957417
Spatial distribution of disease-associated variants in three-dimensional structures of protein complexes. PMID:28945216
Identification of potential cancer-related pseudogenes in lung adenocarcinoma based on ceRNA hypothesis. PMID:28938616
Automatic identification of informative regions with epigenomic changes associated to hematopoiesis. PMID:28934481
The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma. PMID:28931820
Detection of clinically relevant copy number alterations in oral cancer progression using multiplexed droplet digital PCR. PMID:28928368
Comparative study of whole genome amplification and next generation sequencing performance of single cancer cells. PMID:28915574
A pilot study on the use of cerebrospinal fluid cell-free DNA in intramedullary spinal ependymoma. PMID:28900844
Genomic characterization of chromosome translocations in patients with T/myeloid mixed-phenotype acute leukemia. PMID:28882084
TITER: predicting translation initiation sites by deep learning. PMID:28881981
Modeling African American prostate adenocarcinoma by inducing defined genetic alterations in organoids. PMID:28881646
Deep Phospho- and Phosphotyrosine Proteomics Identified Active Kinases and Phosphorylation Networks in Colorectal Cancer Cell Lines Resistant to Cetuximab. PMID:28874695
CRISPR-FOCUS: A web server for designing focused CRISPR screening experiments. PMID:28873439
Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing. PMID:28873162
PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer. PMID:28860563
Identification of cis-regulatory mutations generating de novo edges in personalized cancer gene regulatory networks. PMID:28854983
Overall survival in EGFR mutated non-small-cell lung cancer patients treated with afatinib after EGFR TKI and resistant mechanisms upon disease progression. PMID:28854272
Using ALoFT to determine the impact of putative loss-of-function variants in protein-coding genes. PMID:28851873
In silico prediction of novel therapeutic targets using gene-disease association data. PMID:28851378
Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs. PMID:28850223
FGFR2 amplification in colorectal adenocarcinoma. PMID:28835367
Membrane localization of acetylated CNK1 mediates a positive feedback on RAF/ERK signaling. PMID:28819643
The impact of RNA sequence library construction protocols on transcriptomic profiling of leukemia. PMID:28818039
Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach. PMID:28814482
Carcinogen susceptibility is regulated by genome architecture and predicts cancer mutagenesis. PMID:28814448
Cancerouspdomains: comprehensive analysis of cancer type-specific recurrent somatic mutations in proteins and domains. PMID:28814324
Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma. PMID:28812986
Overexpressed somatic alleles are enriched in functional elements in Breast Cancer. PMID:28811643
Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance. PMID:28794284
Molecular characterization of breast cancer CTCs associated with brain metastasis. PMID:28775303
Molecular Characterization of Somatic Alterations in Dukes' B and C Colorectal Cancers by Targeted Sequencing. PMID:28769798
microRNA-143/145 loss induces Ras signaling to promote aggressive Pten-deficient basal-like breast cancer. PMID:28768903
CRISPR/Cas9-mediated knockout of c-REL in HeLa cells results in profound defects of the cell cycle. PMID:28767691
Versatile ion S5XL sequencer for targeted next generation sequencing of solid tumors in a clinical laboratory. PMID:28767674
High-depth, high-accuracy microsatellite genotyping enables precision lung cancer risk classification. PMID:28759038
Non-canonical IDH1 and IDH2 mutations: a clonal and relevant event in an Italian cohort of gliomas classified according to the 2016 World Health Organization (WHO) criteria. PMID:28748342
Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status. PMID:28744014
Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor. PMID:28741798
Targeted next-generation sequencing supports epidermoid metaplasia of the esophagus as a precursor to esophageal squamous neoplasia. PMID:28731047
Informatics Approaches for Predicting, Understanding, and Testing Cancer Drug Combinations. PMID:28730498
Pathogenetic Analysis of Sinonasal Teratocarcinosarcomas Reveal Actionable β-catenin Overexpression and a β-catenin Mutation. PMID:28725522
A novel molecular diagnostics platform for somatic and germline precision oncology. PMID:28717660
Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines. PMID:28716134
Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. PMID:28714951
Genomic landscape of high-grade meningiomas. PMID:28713588
CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer. PMID:28711281
Somatic mutations in ZFHX4 gene are associated with poor overall survival of Chinese esophageal squamous cell carcinoma patients. PMID:28694483
Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy. PMID:28687338
Metabolomics Applications in Precision Medicine: An Oncological Perspective. PMID:28685691
Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells. PMID:28678170
Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF. PMID:28676500
Pancreatic cancer: Circulating Tumor Cells and Primary Tumors show Heterogeneous KRAS Mutations. PMID:28674438
Mutations in Cancer Cause Gain of Cysteine, Histidine, and Tryptophan at the Expense of a Net Loss of Arginine on the Proteome Level. PMID:28671612
Ultra-sensitive Sequencing Identifies High Prevalence of Clonal Hematopoiesis-Associated Mutations throughout Adult Life. PMID:28669404
Cell signalling pathway regulation by RanBPM: molecular insights and disease implications. PMID:28659384
ISOWN: accurate somatic mutation identification in the absence of normal tissue controls. PMID:28659176
A Massively Parallel Fluorescence Assay to Characterize the Effects of Synonymous Mutations on TP53 Expression. PMID:28652265
An alternative model for (breast) cancer predisposition. PMID:28649653
Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis. PMID:28635960
OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. PMID:28628118
ATM, radiation, and the risk of second primary breast cancer. PMID:28627265
Genomic analysis of follicular dendritic cell sarcoma by molecular inversion probe array reveals tumor suppressor-driven biology. PMID:28621320
Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses. PMID:28619094
Two-step ATP-driven opening of cohesin head. PMID:28607419
Genotype and phenotype spectrum of NRAS germline variants. PMID:28594414
Imbalance-Aware Machine Learning for Predicting Rare and Common Disease-Associated Non-Coding Variants. PMID:28592878
A deep boosting based approach for capturing the sequence binding preferences of RNA-binding proteins from high-throughput CLIP-seq data. PMID:28575488
AACR Project GENIE: Powering Precision Medicine through an International Consortium. PMID:28572459
Metabolic rewiring in mutant Kras lung cancer. PMID:28570035
CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib. PMID:28566333
Advances in the Treatment of Pediatric Bone Sarcomas. PMID:28561686
Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity. PMID:28557434
Germline ETV6 mutations and predisposition to hematological malignancies. PMID:28555414
Genetic background and evolution of relapses in aggressive B-cell lymphomas. PMID:28554945
Oligomonocytic chronic myelomonocytic leukemia (chronic myelomonocytic leukemia without absolute monocytosis) displays a similar clinicopathologic and mutational profile to classical chronic myelomonocytic leukemia. PMID:28548124
CVE: an R package for interactive variant prioritisation in precision oncology. PMID:28545463
AMPK β1 reduces tumor progression and improves survival in p53 null mice. PMID:28544264
Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition. PMID:28537268
HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses. PMID:28533942
Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. PMID:28533407
CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism. PMID:28533324
Role of Epigenetics in Uveal Melanoma. PMID:28529451
TRPS1 gene alterations in human subependymoma. PMID:28528424
Somatic Tumor Mutations Detected by Targeted Next Generation Sequencing in Minute Amounts of Serum-Derived Cell-Free DNA. PMID:28522829
A hydrophobic residue in the TALE homeodomain of PBX1 promotes epithelial-to-mesenchymal transition of gastric carcinoma. PMID:28514754
Molecular basis of targeted therapy in T/NK-cell lymphoma/leukemia: A comprehensive genomic and immunohistochemical analysis of a panel of 33 cell lines. PMID:28505169
Revisiting olfactory receptors as putative drivers of cancer. PMID:28492065
Allelic imbalance of somatic mutations in cancer genomes and transcriptomes. PMID:28490743
Recurrent promoter mutations in melanoma are defined by an extended context-specific mutational signature. PMID:28489852
Identification of a novel RASD1 somatic mutation in a USP8-mutated corticotroph adenoma. PMID:28487882
Whole-genome sequencing identifies homozygous BRCA2 deletion guiding treatment in dedifferentiated prostate cancer. PMID:28487881
Stratification of clear cell renal cell carcinoma (ccRCC) genomes by gene-directed copy number alteration (CNA) analysis. PMID:28486536
Non-V600 BRAF Mutations Define a Clinically Distinct Molecular Subtype of Metastatic Colorectal Cancer. PMID:28486044
BAMClipper: removing primers from alignments to minimize false-negative mutations in amplicon next-generation sequencing. PMID:28484262
Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib. PMID:28484248
Soft Sweeps Are the Dominant Mode of Adaptation in the Human Genome. PMID:28482049
HLJ1 (DNAJB4) Gene Is a Novel Biomarker Candidate in Breast Cancer. PMID:28481734
Exploring background mutational processes to decipher cancer genetic heterogeneity. PMID:28472504
Reliability of algorithmic somatic copy number alteration detection from targeted capture data. PMID:28472276
Sirtuin 2 mutations in human cancers impair its function in genome maintenance. PMID:28461331
Optimized approach for Ion Proton RNA sequencing reveals details of RNA splicing and editing features of the transcriptome. PMID:28459821
QueryOR: a comprehensive web platform for genetic variant analysis and prioritization. PMID:28454514
Multiregional Radiogenomic Assessment of Prostate Microenvironments with Multiparametric MR Imaging and DNA Whole-Exome Sequencing of Prostate Glands with Adenocarcinoma. PMID:28453432
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations. PMID:28445466
Ancient genes establish stress-induced mutation as a hallmark of cancer. PMID:28441401
Clinical sequencing using a next-generation sequencing-based multiplex gene assay in patients with advanced solid tumors. PMID:28440963
Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI. PMID:28440912
PathOS: a decision support system for reporting high throughput sequencing of cancers in clinical diagnostic laboratories. PMID:28438193
Lkb1 deletion in murine B lymphocytes promotes cell death and cancer. PMID:28435024
Multiple components of PKA and TGF-β pathways are mutated in pseudomyxoma peritonei. PMID:28426742
Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors. PMID:28425505
FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma. PMID:28424412
Whole-Exome Sequencing of Metaplastic Breast Carcinoma Indicates Monoclonality with Associated Ductal Carcinoma Component. PMID:28424200
Systematic screening of isogenic cancer cells identifies DUSP6 as context-specific synthetic lethal target in melanoma. PMID:28423600
Robust in-silico identification of cancer cell lines based on next generation sequencing. PMID:28415721
A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma. PMID:28415633
Genetic alterations in seborrheic keratoses. PMID:28410231
Therapeutic Response of Metastatic Colorectal Cancer Harboring a KRAS Missense Mutation After Combination Chemotherapy With the EGFR Inhibitor Panitumumab. PMID:28404754
Mobile Genome Express (MGE): A comprehensive automatic genetic analyses pipeline with a mobile device. PMID:28403238
Omicseq: a web-based search engine for exploring omics datasets. PMID:28402462
A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC). PMID:28397687
Novel miRNA-mRNA interactions conserved in essential cancer pathways. PMID:28387377
The Proteins API: accessing key integrated protein and genome information. PMID:28383659
Testing for the Occurrence of Selective Episodes During the Divergence of Otophysan Fishes: Insights from Mitogenomics. PMID:28378191
Role of CPS1 in Cell Growth, Metabolism and Prognosis in LKB1-Inactivated Lung Adenocarcinoma. PMID:28376202
Drug repurposing from the perspective of pharmaceutical companies. PMID:28369768
Radium-223 Inhibits Osseous Prostate Cancer Growth by Dual Targeting of Cancer Cells and Bone Microenvironment in Mouse Models. PMID:28364014
Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate. PMID:28362259
Whole-genome analysis of papillary kidney cancer finds significant noncoding alterations. PMID:28358873
Identification of a Novel Somatic Mutation Leading to Allele Dropout for EGFR L858R Genotyping in Non-Small Cell Lung Cancer. PMID:28357677
Genomic profiling reveals mutational landscape in parathyroid carcinomas. PMID:28352668
The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies. PMID:28349240
Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector. PMID:28344987
NRAS destines tumor cells to the lungs. PMID:28341702
Epigenomic annotation of noncoding mutations identifies mutated pathways in primary liver cancer. PMID:28333948
A Review of Recent Advancement in Integrating Omics Data with Literature Mining towards Biomedical Discoveries. PMID:28331849
Orchestrating differential data access for translational research: a pilot implementation. PMID:28330491
Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells. PMID:28320353
Non-reproducible sequence artifacts in FFPE tissue: an experience report. PMID:28314930
Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort. PMID:28302137
Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma. PMID:28296713
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity. PMID:28294127
Homeostasis Back and Forth: An Ecoevolutionary Perspective of Cancer. PMID:28289244
Spatial regulation of ARAF controls the MST2-Hippo pathway. PMID:28281933
SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer. PMID:28273073
Precision medicine driven by cancer systems biology. PMID:28265786
Molecular features of early onset adult myelodysplastic syndrome. PMID:28255022
Using cancer genomics to guide clinical decisions. PMID:28253425
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance. PMID:28251903
Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer. PMID:28247034
ZEB1 regulates glioma stemness through LIF repression. PMID:28246407
Modulation of Ras/ERK and Phosphoinositide Signaling by Long-Chain n-3 PUFA in Breast Cancer and Their Potential Complementary Role in Combination with Targeted Drugs. PMID:28241486
Evaluating Variant Calling Tools for Non-Matched Next-Generation Sequencing Data. PMID:28233799
Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy. PMID:28233730
Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation. PMID:28230171
Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. PMID:28202506
Next-generation sequencing in familial breast cancer patients from Lebanon. PMID:28202063
One reporter for in-cell activity profiling of majority of protein kinase oncogenes. PMID:28199182
Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1). PMID:28198434
Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer. PMID:28198375
A novel RNA sequencing data analysis method for cell line authentication. PMID:28192450
MLL5 (KMT2E): structure, function, and clinical relevance. PMID:28188343
Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK. PMID:28188228
Small genomic insertions form enhancers that misregulate oncogenes. PMID:28181482
Human Cell Assays for Synthesis-Dependent Strand Annealing and Crossing over During Double-Strand Break Repair. PMID:28179392
Distribution bias analysis of germline and somatic single-nucleotide variations that impact protein functional site and neighboring amino acids. PMID:28176830
Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung Cancer. PMID:28169345
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. PMID:28162770
DeepGene: an advanced cancer type classifier based on deep learning and somatic point mutations. PMID:28155641
Molecular diagnosis of PIK3CA-related overgrowth spectrum (PROS) in 162 patients and recommendations for genetic testing. PMID:28151489
Prediction of Protein Interactions by Structural Matching: Prediction of PPI Networks and the Effects of Mutations on PPIs that Combines Sequence and Structural Information. PMID:28150242
Differences in the rare variant spectrum among human populations. PMID:28146552
KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. PMID:28145866
Variants of core histones and their roles in cell fate decisions, development and cancer. PMID:28144029
Insights into the pathological mechanisms of p85α mutations using a yeast-based phosphatidylinositol 3-kinase model. PMID:28143957
Synchronous Bilateral Breast Cancer in a Patient With Nager Syndrome. PMID:28139434
Towards standardization of next-generation sequencing of FFPE samples for clinical oncology: intrinsic obstacles and possible solutions. PMID:28137276
Sequencing thousands of single-cell genomes with combinatorial indexing. PMID:28135258
Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas. PMID:28124395
A variant by any name: quantifying annotation discordance across tools and clinical databases. PMID:28122645
Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. PMID:28107588
Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions. PMID:28100566
Juvenile myelomonocytic leukemia-associated variants are associated with neo-natal lethal Noonan syndrome. PMID:28098151
Order Matters: The Order of Somatic Mutations Influences Cancer Evolution. PMID:28096247
Precision oncology for acute myeloid leukemia using a knowledge bank approach. PMID:28092685
Utilizing somatic mutation data from numerous studies for cancer research: proof of concept and applications. PMID:28092680
Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition. PMID:28092667
Genomics pipelines and data integration: challenges and opportunities in the research setting. PMID:28092471
Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing. PMID:28091594
ROS1 Fusions Rarely Overlap with Other Oncogenic Drivers in Non-Small Cell Lung Cancer. PMID:28088512
EGFR L858M/L861Q cis Mutations Confer Selective Sensitivity to Afatinib. PMID:28088511
ClinGen Pathogenicity Calculator: a configurable system for assessing pathogenicity of genetic variants. PMID:28081714
KRAS, NRAS and BRAF mutations in colorectal cancer and melanoma. PMID:28074351
A Survey of Computational Tools to Analyze and Interpret Whole Exome Sequencing Data. PMID:28070503
Genomic hallmarks of localized, non-indolent prostate cancer. PMID:28068672
Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories. PMID:28067867
Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma. PMID:28061437
Colorectal mixed adenoneuroendocrine carcinomas and neuroendocrine carcinomas are genetically closely related to colorectal adenocarcinomas. PMID:28059096
Case report: whole exome sequencing of primary cardiac angiosarcoma highlights potential for targeted therapies. PMID:28056866
INDELseek: detection of complex insertions and deletions from next-generation sequencing data. PMID:28056804
Identification of coding and non-coding mutational hotspots in cancer genomes. PMID:28056774
POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins. PMID:28053162
The 24th annual Nucleic Acids Research database issue: a look back and upcoming changes. PMID:28053160
Competing endogenous RNA network analysis identifies critical genes among the different breast cancer subtypes. PMID:28052038
In vivo severity ranking of Ras pathway mutations associated with developmental disorders. PMID:28049852
Structural characterization of nonactive site, TrkA-selective kinase inhibitors. PMID:28039433
Evolution-informed modeling improves outcome prediction for cancers. PMID:28035236
Anaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not ligand-independent. PMID:28030793
Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions. PMID:28030567
Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis. PMID:28027327
Genomic Analysis of Uterine Lavage Fluid Detects Early Endometrial Cancers and Reveals a Prevalent Landscape of Driver Mutations in Women without Histopathologic Evidence of Cancer: A Prospective Cross-Sectional Study. PMID:28027320
The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE". PMID:28027312
Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution. PMID:28027311
The Mutational Landscape of the Oncogenic MZF1 SCAN Domain in Cancer. PMID:28018905
Mutations in EBF3 Disturb Transcriptional Profiles and Cause Intellectual Disability, Ataxia, and Facial Dysmorphism. PMID:28017373
VaProS: a database-integration approach for protein/genome information retrieval. PMID:28012137
iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing driver genes in personal cancer genomes. PMID:28007024
Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells. PMID:28002807
A bedr way of genomic interval processing. PMID:27999613
Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy. PMID:27997592
Somatic Mutations in Prostate Cancer: Closer to Personalized Medicine. PMID:27995550
Association between the KRAS Gene Polymorphisms and Papillary Thyroid Carcinoma in a Chinese Han Population. PMID:27994680
Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists. PMID:27993330
Targeting β-catenin in hepatocellular cancers induced by coexpression of mutant β-catenin and K-Ras in mice. PMID:27981621
Statistical Methods for Identifying Sequence Motifs Affecting Point Mutations. PMID:27974498
Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice. PMID:27956228
K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression. PMID:27934968
Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines. PMID:27933395
Integrating next-generation sequencing into clinical oncology: strategies, promises and pitfalls. PMID:27933214
A novel class of somatic mutations in blood detected preferentially in CD8+ cells. PMID:27932211
Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases. PMID:27923045
Identification of critical paralog groups with indispensable roles in the regulation of signaling flow. PMID:27922122
Localized structural frustration for evaluating the impact of sequence variants. PMID:27915290
sCNAphase: using haplotype resolved read depth to genotype somatic copy number alterations from low cellularity aneuploid tumors. PMID:27903916
dbSAP: single amino-acid polymorphism database for protein variation detection. PMID:27903894
Intrinsic HER2 V777L mutation mediates resistance to trastuzumab in a breast cancer patient. PMID:27900589
Patterns of Transposable Element Expression and Insertion in Cancer. PMID:27900322
Open Targets: a platform for therapeutic target identification and validation. PMID:27899665
The neXtProt knowledgebase on human proteins: 2017 update. PMID:27899619
MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search. PMID:27899610
COSMIC: somatic cancer genetics at high-resolution. PMID:27899578
ChimerDB 3.0: an enhanced database for fusion genes from cancer transcriptome and literature data mining. PMID:27899563
pathDIP: an annotated resource for known and predicted human gene-pathway associations and pathway enrichment analysis. PMID:27899558
Molecular predictive markers in tumors of the gastrointestinal tract. PMID:27895815
The Genome Conformation As an Integrator of Multi-Omic Data: The Example of Damage Spreading in Cancer. PMID:27895661
Investigating cytokinesis failure as a strategy in cancer therapy. PMID:27895316
The epigenetic landscape of renal cancer. PMID:27890923
Cancer somatic mutations cluster in a subset of regulatory sites predicted from the ENCODE data. PMID:27887606
Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer. PMID:27881443
In-depth comparison of somatic point mutation callers based on different tumor next-generation sequencing depth data. PMID:27874022
Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer. PMID:27869171
In silico SNP analysis of the breast cancer antigen NY-BR-1. PMID:27863482
Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases. PMID:27859906
Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer. PMID:27859262
KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer. PMID:27859136
Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer. PMID:27855189
Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma. PMID:27852700
Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling. PMID:27851986
Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motions. PMID:27845397
Identification of a rare germline NBN gene mutation by whole exome sequencing in a lung-cancer survivor from a large family with various types of cancer. PMID:27844240
Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma. PMID:27837031
Overexpression of KLHL23 protein from read-through transcription of PHOSPHO2-KLHL23 in gastric cancer increases cell proliferation. PMID:27833855
A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preference. PMID:27831464
Somatic cancer variant curation and harmonization through consensus minimum variant level data. PMID:27814769
IDICAP: A Novel Tool for Integrating Drug Intervention Based on Cancer Panel. PMID:27801815
A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. PMID:27799065
The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress. PMID:27797818
Comparative analysis of protein interactome networks prioritizes candidate genes with cancer signatures. PMID:27791983
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ. PMID:27791178
Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition. PMID:27791010
GenomeCRISPR - a database for high-throughput CRISPR/Cas9 screens. PMID:27789686
The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations. PMID:27789569
Whole-exome sequencing of Finnish hereditary breast cancer families. PMID:27782108
Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival. PMID:27776121
Dissecting the biological relationship between TCGA miRNA and mRNA sequencing data using MMiRNA-Viewer. PMID:27766936
Impact of RNA degradation on fusion detection by RNA-seq. PMID:27765019
Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants. PMID:27760319
Using Pharmacogenomic Databases for Discovering Patient-Target Genes and Small Molecule Candidates to Cancer Therapy. PMID:27746730
Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis. PMID:27734031
The human-induced pluripotent stem cell initiative-data resources for cellular genetics. PMID:27733501
KinView: a visual comparative sequence analysis tool for integrated kinome research. PMID:27731453
Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation. PMID:27721458
Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics. PMID:27721410
Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies. PMID:27713118
MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis. PMID:27705918
Insights into cancer severity from biomolecular interaction mechanisms. PMID:27698488
Acquired METD1228V Mutation and Resistance to MET Inhibition in Lung Cancer. PMID:27694386
DoCM: a database of curated mutations in cancer. PMID:27684579
Single Synonymous Mutations in KRAS Cause Transformed Phenotypes in NIH3T3 Cells. PMID:27684555
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors. PMID:27684276
Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy. PMID:27683556
Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. PMID:27683039
Molecular Genetic Characterization of Individual Cancer Cells Isolated via Single-Cell Printing. PMID:27658049
Oncogene Mutations in Colorectal Polyps Identified in the Norwegian Colorectal Cancer Prevention (NORCCAP) Screening Study. PMID:27656095
CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network. PMID:27650546
Prognostic significance of MST1R dysregulation in renal cell tumors. PMID:27648366
MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer. PMID:27638352
Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane. PMID:27630059
Integrated tumor and germline whole-exome sequencing identifies mutations in MAPK and PI3K pathway genes in an adolescent with rosette-forming glioneuronal tumor of the fourth ventricle. PMID:27626068
FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma. PMID:27625374
The rules and impact of nonsense-mediated mRNA decay in human cancers. PMID:27618451
G-quadruplex structures mark human regulatory chromatin. PMID:27618450
Role of CDKN2C Copy Number in Sporadic Medullary Thyroid Carcinoma. PMID:27610696
Subclonal diversity arises early even in small colorectal tumours and contributes to differential growth fates. PMID:27609830
Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer. PMID:27602502
Association of FGD1 polymorphisms with early-onset breast cancer. PMID:27602141
Genomic Instability of iPSCs: Challenges Towards Their Clinical Applications. PMID:27592701
Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity. PMID:27588951
A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma. PMID:27588520
DMBA induced mouse mammary tumors display high incidence of activating Pik3caH1047 and loss of function Pten mutations. PMID:27588403
Classification of breast cancer patients using somatic mutation profiles and machine learning approaches. PMID:27587275
Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake. PMID:27587023
XMRF: an R package to fit Markov Networks to high-throughput genetics data. PMID:27586041
Self-regulation of functional pathways by motifs inside the disordered tails of beta-catenin. PMID:27585692
Testicular germ cell tumor genomics. PMID:27584029
Performance comparison of two commercial human whole-exome capture systems on formalin-fixed paraffin-embedded lung adenocarcinoma samples. PMID:27578032
Tiered Human Integrated Sequence Search Databases for Shotgun Proteomics. PMID:27577934
RNA2DNAlign: nucleotide resolution allele asymmetries through quantitative assessment of RNA and DNA paired sequencing data. PMID:27576531
Multi-omics analysis of primary glioblastoma cell lines shows recapitulation of pivotal molecular features of parental tumors. PMID:27571888
G23D: Online tool for mapping and visualization of genomic variants on 3D protein structures. PMID:27565432
Concurrent ARID1A and ARID1B inactivation in endometrial and ovarian dedifferentiated carcinomas. PMID:27562491
Drug-Driven Synthetic Lethality: Bypassing Tumor Cell Genetics with a Combination of AsiDNA and PARP Inhibitors. PMID:27559053
Association mining of mutated cancer genes in different clinical stages across 11 cancer types. PMID:27556693
One-Tube-Only Standardized Site-Directed Mutagenesis: An Alternative Approach to Generate Amino Acid Substitution Collections. PMID:27548698
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults. PMID:27546487
Medullary Thyroid Carcinoma: Recent Advances Including MicroRNA Expression. PMID:27539727
The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development. PMID:27536874
Sensitivity to PRIMA-1MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 status. PMID:27533246
IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias. PMID:27532210
Punctuated copy number evolution and clonal stasis in triple-negative breast cancer. PMID:27526321
Phosphorylation Sites Identified in the NEIL1 DNA Glycosylase Are Potential Targets for the JNK1 Kinase. PMID:27518429
AKT1 (E17K) mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection. PMID:27515171
Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk. PMID:27514407
VHLdb: A database of von Hippel-Lindau protein interactors and mutations. PMID:27511743
The transposable element environment of human genes is associated with histone and expression changes in cancer. PMID:27506777
High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML. PMID:27498870
Y-family DNA polymerase-independent gap-filling translesion synthesis across aristolochic acid-derived adenine adducts in mouse cells. PMID:27497692
Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types. PMID:27490693
S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma. PMID:27489352
A gene browser of colorectal cancer with literature evidence and pre-computed regulatory information to identify key tumor suppressors and oncogenes. PMID:27477450
GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation. PMID:27476652
Clinical activity and safety of Pembrolizumab in Ipilimumab pre-treated patients with uveal melanoma. PMID:27467964
JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships. PMID:27466283
Reduced miR-550a-3p leads to breast cancer initiation, growth, and metastasis by increasing levels of ERK1 and 2. PMID:27462780
Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences. PMID:27462411
Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia. PMID:27461063
The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine. PMID:27460824
Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer. PMID:27452523
Clinical Outcomes of TP53 Mutations in Cancers. PMID:27449973
EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations. PMID:27443517
Galectin-3 interacts with components of the nuclear ribonucleoprotein complex. PMID:27435226
Protein function in precision medicine: deep understanding with machine learning. PMID:27423136
Somatic mutations predict outcomes of hypomethylating therapy in patients with myelodysplastic syndrome. PMID:27419369
A germline ERBB3 variant is a candidate for predisposition to erythroid MDS/erythroleukemia. PMID:27416908
Germline MC1R status influences somatic mutation burden in melanoma. PMID:27403562
Whole Genome Pathway Analysis Identifies an Association of Cadmium Response Gene Loss with Copy Number Variation in Mutant p53 Bearing Uterine Endometrial Carcinomas. PMID:27391266
Independent Tumor Origin in Two Cases of Synchronous Bilateral Clear Cell Renal Cell Carcinoma. PMID:27383411
Computational genomics tools for dissecting tumour-immune cell interactions. PMID:27376489
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. PMID:27373337
Deep Genetic Connection Between Cancer and Developmental Disorders. PMID:27363847
Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias. PMID:27363283
VarElect: the phenotype-based variation prioritizer of the GeneCards Suite. PMID:27357693
Intrinsic protein disorder in histone lysine methylation. PMID:27356874
Therapeutic Approaches to RAS Mutation. PMID:27341593
QuIN: A Web Server for Querying and Visualizing Chromatin Interaction Networks. PMID:27336171
Stuxnet Facilitates the Degradation of Polycomb Protein during Development. PMID:27326929
A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma. PMID:27324824
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia. PMID:27322744
FANCD2 limits replication stress and genome instability in cells lacking BRCA2. PMID:27322732
PTENpred: A Designer Protein Impact Predictor for PTEN-related Disorders. PMID:27310656
Fbw7 and Usp28 - enemies and allies. PMID:27308481
Structural Mechanisms and Drug Discovery Prospects of Rho GTPases. PMID:27304967
Gain-of-Function Mutations in the Toll-Like Receptor Pathway: TPL2-Mediated ERK1/ERK2 MAPK Activation, a Path to Tumorigenesis in Lymphoid Neoplasms? PMID:27303665
The Size of the Human Proteome: The Width and Depth. PMID:27298622
Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine. PMID:27296290
Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1. PMID:27286452
Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers. PMID:27273737
Predicting regulatory variants with composite statistic. PMID:27273672
Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned. PMID:27255914
Development and clinical application of an integrative genomic approach to personalized cancer therapy. PMID:27245685
Longitudinal molecular characterization of endoscopic specimens from colorectal lesions. PMID:27239120
Long noncoding RNAs in cancer: mechanisms of action and technological advancements. PMID:27233618
Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation. PMID:27232191
Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. PMID:27229929
Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1). PMID:27226556
PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions. PMID:27224906
Nonoverlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi. PMID:27220476
Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression. PMID:27217562
A hot L1 retrotransposon evades somatic repression and initiates human colorectal cancer. PMID:27197217
Analysis of Paired Primary-Metastatic Hormone-Receptor Positive Breast Tumors (HRPBC) Uncovers Potential Novel Drivers of Hormonal Resistance. PMID:27195705
Targeted sequencing of BRCA1 and BRCA2 across a large unselected breast cancer cohort suggests that one-third of mutations are somatic. PMID:27194814
Practical aspects of NGS-based pathways analysis for personalized cancer science and medicine. PMID:27191992
SETD2: an epigenetic modifier with tumor suppressor functionality. PMID:27191891
Nephroblastomatosis or Wilms tumor in a fourth patient with a somatic PIK3CA mutation. PMID:27191687
The Somatic Nature of Cancer Allows It to Affect Highly Constrained Genes. PMID:27190005
CTLPScanner: a web server for chromothripsis-like pattern detection. PMID:27185889
Biological function derived from predicted structures in CASP11. PMID:27181425
Frequent mutations in acetylation and ubiquitination sites suggest novel driver mechanisms of cancer. PMID:27175787
The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas. PMID:27175599
Proteome-wide search for functional motifs altered in tumors: Prediction of nuclear export signals inactivated by cancer-related mutations. PMID:27174732
NLRC5/MHC class I transactivator is a target for immune evasion in cancer. PMID:27162338
Computational approaches for predicting mutant protein stability. PMID:27160393
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas. PMID:27158780
Gender Specific Differences in RNA Polymerase III Transcription. PMID:27158556
Identification of cancer-driver genes in focal genomic alterations from whole genome sequencing data. PMID:27156852
High-performance web services for querying gene and variant annotation. PMID:27154141
PinSnps: structural and functional analysis of SNPs in the context of protein interaction networks. PMID:27153707
Functional oncogene signatures guide rationally designed combination therapies to synergistically induce breast cancer cell death. PMID:27153554
RAD51 variant proteins from human lung and kidney tumors exhibit DNA strand exchange defects. PMID:27153211
StructMAn: annotation of single-nucleotide polymorphisms in the structural context. PMID:27150811
Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development. PMID:27150584
Molecular analysis of a male breast cancer patient with prolonged stable disease under mTOR/PI3K inhibitors BEZ235/everolimus. PMID:27148582
Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples. PMID:27146902
Genetic Characteristics of Polycythemia Vera and Essential Thrombocythemia in Korean Patients. PMID:27132877
GCGene: a gene resource for gastric cancer with literature evidence. PMID:27127885
Long-term vemurafenib treatment drives inhibitor resistance through a spontaneous KRAS G12D mutation in a BRAF V600E papillary thyroid carcinoma model. PMID:27127178
Parkinson disease (PARK) genes are somatically mutated in cutaneous melanoma. PMID:27123489
Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia. PMID:27118405
VDAC2-specific cellular functions and the underlying structure. PMID:27116927
CoReCG: a comprehensive database of genes associated with colon-rectal cancer. PMID:27114494
Defining actionable mutations for oncology therapeutic development. PMID:27112209
CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes. PMID:27111720
Germline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures. PMID:27108799
TP53, PIK3CA, FBXW7 and KRAS Mutations in Esophageal Cancer Identified by Targeted Sequencing. PMID:27107065
Pooled-matrix protein interaction screens using Barcode Fusion Genetics. PMID:27107012
Discovering and understanding oncogenic gene fusions through data intensive computational approaches. PMID:27105842
A somatic reference standard for cancer genome sequencing. PMID:27094764
MutSpec: a Galaxy toolbox for streamlined analyses of somatic mutation spectra in human and mouse cancer genomes. PMID:27091472
Prioritizing functional phosphorylation sites based on multiple feature integration. PMID:27090940
Monovar: single-nucleotide variant detection in single cells. PMID:27088313
Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences. PMID:27084947
Mutation Yield of a 34-Gene Solid Tumor Panel in Community-Based Tumor Samples. PMID:27084556
GRN and MAPT Mutations in 2 Frontotemporal Dementia Research Centers in Brazil. PMID:27082848
Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants Through Conformational Sampling Approach. PMID:27081308
An NGS Workflow Blueprint for DNA Sequencing Data and Its Application in Individualized Molecular Oncology. PMID:27081306
Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer. PMID:27081080
BRONCO: Biomedical entity Relation ONcology COrpus for extracting gene-variant-disease-drug relations. PMID:27074804
JBrowse: a dynamic web platform for genome visualization and analysis. PMID:27072794
The potential utility of re-mining results of somatic mutation testing: KRAS status in lung adenocarcinoma. PMID:27068338
Establishment and Characterization of a Human Neuroendocrine Tumor Xenograft. PMID:27067082
VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research. PMID:27060149
Empowered genome community: leveraging a bioinformatics platform as a citizen-scientist collaboration tool. PMID:27054071
Aberrant hnRNP K expression: All roads lead to cancer. PMID:27049467
De novo mutations in CSNK2A1 are associated with neurodevelopmental abnormalities and dysmorphic features. PMID:27048600
The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants. PMID:27043589
Structure-Based Analysis Reveals Cancer Missense Mutations Target Protein Interaction Interfaces. PMID:27043210
Somatic Mutations and Genetic Variants of NOTCH1 in Head and Neck Squamous Cell Carcinoma Occurrence and Development. PMID:27035284
Long range recognition and selection in IDPs: the interactions of the C-terminus of p53. PMID:27030593
Expression of epithelial-mesenchymal transition-related genes increases with copy number in multiple cancer types. PMID:27029057
Integrated digital error suppression for improved detection of circulating tumor DNA. PMID:27018799
Genomic landscape of DNA repair genes in cancer. PMID:27004405
KDR Mutation as a Novel Predictive Biomarker of Exceptional Response to Regorafenib in Metastatic Colorectal Cancer. PMID:27004155
Wikidata as a semantic framework for the Gene Wiki initiative. PMID:26989148
Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen. PMID:26989080
Emerging applications of metabolomics in drug discovery and precision medicine. PMID:26965202
Reciprocal positive selection for weakness - preventing olaparib resistance by inhibiting BRCA2. PMID:26959114
Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines. PMID:26947069
On Predicting lung cancer subtypes using 'omic' data from tumor and tumor-adjacent histologically-normal tissue. PMID:26944944
Two novel germline DDX41 mutations in a family with inherited myelodysplasia/acute myeloid leukemia. PMID:26944477
DNA methylation in normal and malignant hematopoiesis. PMID:26943352
The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation. PMID:26943038
An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer. PMID:26921330
Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs. PMID:26906009
Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3. PMID:26883108
An open access pilot freely sharing cancer genomic data from participants in Texas. PMID:26882539
The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks. PMID:26877236
Frequent HRAS Mutations in Malignant Ectomesenchymoma: Overlapping Genetic Abnormalities With Embryonal Rhabdomyosarcoma. PMID:26872011
miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma. PMID:26871295
Simvastatin Sodium Salt and Fluvastatin Interact with Human Gap Junction Gamma-3 Protein. PMID:26863535
Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes. PMID:26858415
A novel mutation in CELSR1 is associated with hereditary lymphedema. PMID:26855770
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. PMID:26855148
Tumor suppressor properties of the splicing regulatory factor RBM10. PMID:26853560
Aberrant epigenetic regulation in clear cell sarcoma of the kidney featuring distinct DNA hypermethylation and EZH2 overexpression. PMID:26848979
A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men. PMID:26844274
Toward Repurposing Metformin as a Precision Anti-Cancer Therapy Using Structural Systems Pharmacology. PMID:26841718
Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner. PMID:26832796
Copy number gain of PIK3CA and MET is associated with poor prognosis in head and neck squamous cell carcinoma. PMID:26832731
Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2. PMID:26825711
Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors. PMID:26822237
PDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δ. PMID:26819372
The PI3K/Akt Pathway in Tumors of Endocrine Tissues. PMID:26793165
Simultaneous Underexpression of let-7a-5p and let-7f-5p microRNAs in Plasma and Stool Samples from Early Stage Colorectal Carcinoma. PMID:26793011
Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs. PMID:26781748
The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapies. PMID:26772741
A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. PMID:26771498
Farewell to GBM-O: Genomic and transcriptomic profiling of glioblastoma with oligodendroglioma component reveals distinct molecular subgroups. PMID:26757882
Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs. PMID:26755435
Computational analysis of prolyl hydroxylase domain-containing protein 2 (PHD2) mutations promoting polycythemia insurgence in humans. PMID:26754054
Integrating 400 million variants from 80,000 human samples with extensive annotations: towards a knowledge base to analyze disease cohorts. PMID:26746786
Direct Calculation of Protein Fitness Landscapes through Computational Protein Design. PMID:26745411
Macrophage Migration Inhibitory Factor Secretion Is Induced by Ionizing Radiation and Oxidative Stress in Cancer Cells. PMID:26741693
Big Data for Cancer Research. PMID:26740748
Molecular Evolution of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene Nrf2 in Old World Fruit Bats (Chiroptera: Pteropodidae). PMID:26735303
A spectral approach integrating functional genomic annotations for coding and noncoding variants. PMID:26727659
EGFR phosphorylates FAM129B to promote Ras activation. PMID:26721396
Exploring genomic alteration in pediatric cancer using ProteinPaint. PMID:26711108
Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease. PMID:26708421
Ensembl 2016. PMID:26687719
Selective amino acid restriction therapy (SAART): a non-pharmacological strategy against all types of cancer cells. PMID:26682277
Targeted next-generation sequencing panel (GlioSeq) provides comprehensive genetic profiling of central nervous system tumors. PMID:26681766
Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes. PMID:26681674
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors. PMID:26675378
Alterations of the immunosuppressive IL4I1 enzyme activity induced by naturally occurring SNP/mutations. PMID:26673964
Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity. PMID:26672766
Proteogenomics from a bioinformatics angle: A growing field. PMID:26670565
TP53 mutational status is predictive of pazopanib response in advanced sarcomas. PMID:26646755
Liquid biopsy for detection of actionable oncogenic mutations in human cancers and electric field induced release and measurement liquid biopsy (eLB). PMID:26645892
RBP-Var: a database of functional variants involved in regulation mediated by RNA-binding proteins. PMID:26635394
DriverDBv2: a database for human cancer driver gene research. PMID:26635391
An integrative somatic mutation analysis to identify pathways linked with survival outcomes across 19 cancer types. PMID:26635139
Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2A/B Deletion. PMID:26634163
Covalent targeting of acquired cysteines in cancer. PMID:26629855
Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia. PMID:26626780
Fast dimension reduction and integrative clustering of multi-omics data using low-rank approximation: application to cancer molecular classification. PMID:26626453
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. PMID:26619011
Regulators of genetic risk of breast cancer identified by integrative network analysis. PMID:26618344
GWASdb v2: an update database for human genetic variants identified by genome-wide association studies. PMID:26615194
Analytical Validation and Application of a Targeted Next-Generation Sequencing Mutation-Detection Assay for Use in Treatment Assignment in the NCI-MPACT Trial. PMID:26602013
Posttranscriptional methylation of transfer and ribosomal RNA in stress response pathways, cell differentiation, and cancer. PMID:26599292
A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity. PMID:26598692
PRL-3 activates mTORC1 in Cancer Progression. PMID:26597054
CancerResource--updated database of cancer-relevant proteins, mutations and interacting drugs. PMID:26590406
BreCAN-DB: a repository cum browser of personalized DNA breakpoint profiles of cancer genomes. PMID:26586806
Comprehensive evaluation of fusion transcript detection algorithms and a meta-caller to combine top performing methods in paired-end RNA-seq data. PMID:26582927
Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy. PMID:26582713
Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis. PMID:26578795
SomamiR 2.0: a database of cancer somatic mutations altering microRNA-ceRNA interactions. PMID:26578591
Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cells. PMID:26576332
The potential role of PHF6 as an oncogene: a genotranscriptomic/proteomic meta-analysis. PMID:26561469
The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome. PMID:26551667
Comparison of genetic variants in matched samples using thesaurus annotation. PMID:26545822
LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes. PMID:26545813
HOXB9 induction of mesenchymal-to-epithelial transition in gastric carcinoma is negatively regulated by its hexapeptide motif. PMID:26536658
Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers. PMID:26523969
Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study. PMID:26522332
Autophagy and AML--food for thought. PMID:26517530
Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers. PMID:26515115
Bioinformatics Knowledge Map for Analysis of Beta-Catenin Function in Cancer. PMID:26509276
The Cancer Genome Atlas Clinical Explorer: a web and mobile interface for identifying clinical-genomic driver associations. PMID:26507825
Whole exome sequencing of microdissected splenic marginal zone lymphoma: a study to discover novel tumor-specific mutations. PMID:26498442
Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues. PMID:26496946
Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing. PMID:26496030
GREM1 and POLE variants in hereditary colorectal cancer syndromes. PMID:26493165
Expression of histone methyltransferases as novel biomarkers for renal cell tumor diagnosis and prognostication. PMID:26488939
The human gene damage index as a gene-level approach to prioritizing exome variants. PMID:26483451
Lnc2Cancer: a manually curated database of experimentally supported lncRNAs associated with various human cancers. PMID:26481356
A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients. PMID:26474971
Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties. PMID:26468652
The genomic landscape of juvenile myelomonocytic leukemia. PMID:26457647
Structural Analysis of the Pin1-CPEB1 interaction and its potential role in CPEB1 degradation. PMID:26456073
Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma. PMID:26452128
An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System. PMID:26447128
Comprehensive serial molecular profiling of an "N of 1" exceptional non-responder with metastatic prostate cancer progressing to small cell carcinoma on treatment. PMID:26444865
Sensitivity of plasma BRAFmutant and NRASmutant cell-free DNA assays to detect metastatic melanoma in patients with low RECIST scores and non-RECIST disease progression. PMID:26440707
Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway. PMID:26440310
Remarkable similarities of chromosomal rearrangements between primary human breast cancers and matched distant metastases as revealed by whole-genome sequencing. PMID:26439695
Full-length nucleotide sequences of 30 common SLC44A2 alleles encoding human neutrophil antigen-3. PMID:26437811
Actionable clinical decisions based on comprehensive genomic evaluation in asymptomatic adults. PMID:26436109
ExoCarta: A Web-Based Compendium of Exosomal Cargo. PMID:26434508
Intracellular Mono-ADP-Ribosylation in Signaling and Disease. PMID:26426055
Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer. PMID:26424751
The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants. PMID:26408825
Next-Generation Sequencing Approaches in Cancer: Where Have They Brought Us and Where Will They Take Us? PMID:26404381
Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas. PMID:26402468
LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner. PMID:26400164
FARE-CAFE: a database of functional and regulatory elements of cancer-associated fusion events. PMID:26384373
Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid. PMID:26383547
FANCA safeguards interphase and mitosis during hematopoiesis in vivo. PMID:26366677
Molecular basis underlying resistance to Mps1/TTK inhibitors. PMID:26364596
The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice. PMID:26360410
A systematic analysis reveals heterogeneous changes in the endocytic activities of cancer cells. PMID:26359453
RICTOR involvement in the PI3K/AKT pathway regulation in melanocytes and melanoma. PMID:26356562
Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants. PMID:26354769
Computational approaches to study the effects of small genomic variations. PMID:26350246
The Structural Characterization of Tumor Fusion Genes and Proteins. PMID:26347798
Challenges in exome analysis by LifeScope and its alternative computational pipelines. PMID:26346699
ClinLabGeneticist: a tool for clinical management of genetic variants from whole exome sequencing in clinical genetic laboratories. PMID:26338694
Translational control by lysine-encoding A-rich sequences. PMID:26322332
Beyond genomics: critical evaluation of cell line utility for ovarian cancer research. PMID:26321251
Cancer Driver Log (CanDL): Catalog of Potentially Actionable Cancer Mutations. PMID:26320871
Next-generation sequencing: hype and hope for development of personalized radiation therapy? PMID:26316159
Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomes. PMID:26307061
Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance. PMID:26299805
Is Cancer a Genetic Disease or a Metabolic Disease? PMID:26288805
EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib. PMID:26286086
Cancer: leaping the E-cadherin hurdle. PMID:26282791
Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma. PMID:26276629
PTEN and NEDD4 in Human Breast Carcinoma. PMID:26276352
ExScalibur: A High-Performance Cloud-Enabled Suite for Whole Exome Germline and Somatic Mutation Identification. PMID:26271043
Phospho-T356RB1 predicts survival in HPV-negative squamous cell carcinoma of the head and neck. PMID:26265441
Point mutations of the mTOR-RHEB pathway in renal cell carcinoma. PMID:26255626
Structural integration in hypoxia-inducible factors. PMID:26245371
Contralateral breast cancer can represent a metastatic spread of the first primary tumor: determination of clonal relationship between contralateral breast cancers using next-generation whole genome sequencing. PMID:26242876
Oligonucleotide gap-fill ligation for mutation detection and sequencing in situ. PMID:26240388
Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. PMID:26234763
Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3. PMID:26229104
Mastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling. PMID:26225565
Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity. PMID:26212640
Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia. PMID:26206799
Atlas of Cancer Signalling Network: a systems biology resource for integrative analysis of cancer data with Google Maps. PMID:26192618
eIF3 controls cell size independently of S6K1-activity. PMID:26172298
Mutation-induced protein interaction kinetics changes affect apoptotic network dynamic properties and facilitate oncogenesis. PMID:26170328
Comprehensive genomic profiles of small cell lung cancer. PMID:26168399
Genetic mutations in human rectal cancers detected by targeted sequencing. PMID:26134512
An Efficient Method for Identifying Gene Fusions by Targeted RNA Sequencing from Fresh Frozen and FFPE Samples. PMID:26132974
Functional annotation of HOT regions in the human genome: implications for human disease and cancer. PMID:26113264
Computational methods and resources for the interpretation of genomic variants in cancer. PMID:26111056
Only one health, and so many omics. PMID:26101467
The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease. PMID:26066981
Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype. PMID:26033320
Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. PMID:26030179
Aneuploidy and chromosomal instability in cancer: a jackpot to chaos. PMID:26015801
Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples. PMID:26010451
The cancer cell map initiative: defining the hallmark networks of cancer. PMID:26000852
Getting personal: Head and neck cancer management in the era of genomic medicine. PMID:25995036
The impact of DNA input amount and DNA source on the performance of whole-exome sequencing in cancer epidemiology. PMID:25990554
Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling. PMID:25957506
Translational value of mouse models in oncology drug development. PMID:25951530
Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes. PMID:25944692
Structural determinants of Smad function in TGF-β signaling. PMID:25935112
Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors. PMID:25925381
A wide spectrum of EGFR mutations in glioblastoma is detected by a single clinical oncology targeted next-generation sequencing panel. PMID:25910966
SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering. PMID:25903787
Competing endogenous RNA networks: tying the essential knots for cancer biology and therapeutics. PMID:25888444
A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine. PMID:25860647
Generating a focused view of disease ontology cancer terms for pan-cancer data integration and analysis. PMID:25841438
Cancer whole-genome sequencing: present and future. PMID:25823020
New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma. PMID:25803323
Analysis of human upstream open reading frames and impact on gene expression. PMID:25800702
Personalized oncogenomics: clinical experience with malignant peritoneal mesothelioma using whole genome sequencing. PMID:25798586
Mutational dichotomy in desmoplastic malignant melanoma corroborated by multigene panel analysis. PMID:25769001
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis. PMID:25732814
Rapid mass spectrometric conversion of tissue biopsy samples into permanent quantitative digital proteome maps. PMID:25730263
Leveraging DNA damage response signaling to identify yeast genes controlling genome stability. PMID:25721128
Biological databases for human research. PMID:25712261
Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development. PMID:25712196
Databases and web tools for cancer genomics study. PMID:25707591
Lymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CA. PMID:25681199
Spectrin binding motifs regulate Scribble cortical dynamics and polarity function. PMID:25664942
Conformational stability and catalytic activity of PTEN variants linked to cancers and autism spectrum disorders. PMID:25647146
The 2015 Nucleic Acids Research Database Issue and molecular biology database collection. PMID:25593347
Targeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer. PMID:25590805
VarSim: a high-fidelity simulation and validation framework for high-throughput genome sequencing with cancer applications. PMID:25524895
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. PMID:25512523
Protein residues that control the reaction trajectory in S-adenosylmethionine radical enzymes: mutagenesis of asparagine 153 and aspartate 155 in Escherichia coli biotin synthase. PMID:19199517
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer PubMed citations: 1231.

1231 articles citing: COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

Role of Senescence in Tumorigenesis and Anticancer Therapy. PMID:35342397
Clinical and molecular features of sacrum chordoma in Chinese patients. PMID:35282040
Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas. PMID:35264242
A pan-cancer landscape of telomeric content shows that RAD21 and HGF alterations are associated with longer telomeres. PMID:35227290
Experimental Nuclear Medicine Meets Tumor Biology. PMID:35215337
In silico bioinformatics analysis for identification of differentially expressed genes and therapeutic drug molecules in Glucocorticoid-resistant Multiple myeloma. PMID:35150335
Computational Prediction of the Pathogenic Status of Cancer-Specific Somatic Variants. PMID:35116056
The mixed blessing of AMPK signaling in Cancer treatments. PMID:35078427
RNA-seq analysis of the human surfactant air-liquid interface culture reveals alveolar type II cell-like transcriptome. PMID:34977273
Application of Sparse Representation in Bioinformatics. PMID:34976030
Targeting KRAS in NSCLC: Old Failures and New Options for "Non-G12c" Patients. PMID:34944952
MutTMPredictor: Robust and accurate cascade XGBoost classifier for prediction of mutations in transmembrane proteins. PMID:34938415
CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications. PMID:34925370
Untangling the KRAS mutated lung cancer subsets and its therapeutic implications. PMID:34918209
Targeting Mutated KRAS Genes to Treat Solid Tumours. PMID:34914038
Chromothripsis in Chronic Lymphocytic Leukemia: A Driving Force of Genome Instability. PMID:34900721
DNA methylation variation along the cancer epigenome and the identification of novel epigenetic driver events. PMID:34871444
Stepwise correlation of TP53 mutations from pancreaticobiliary maljunction to gallbladder carcinoma: a retrospective study. PMID:34798839
Integrative Generalized Convex Clustering Optimization and Feature Selection for Mixed Multi-View Data. PMID:34744522
The Genetic Basis of Phenotypic Heterogeneity in the Neuronal Ceroid Lipofuscinoses. PMID:34733232
Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers. PMID:34702252
Deep learning for cancer type classification and driver gene identification. PMID:34689757
Comprehensive landscape and interference of clonal haematopoiesis mutations for liquid biopsy: A Chinese pan-cancer cohort. PMID:34658138
UNMASC: tumor-only variant calling with unmatched normal controls. PMID:34632388
mTOR Signaling: The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication. PMID:34580816
Crosstalk of the Wnt/β-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells. PMID:34577571
Gene expression profiling utilizing extremely sensitive CDNA arrays and enrichment-based network study of major bone cancer genes. PMID:34484381
Targeting enhancer reprogramming to mitigate MEK inhibitor resistance in preclinical models of advanced ovarian cancer. PMID:34464356
Extracting Concepts for Precision Oncology from the Biomedical Literature. PMID:34457142
Biomolecule and Bioentity Interaction Databases in Systems Biology: A Comprehensive Review. PMID:34439912
PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPARγ-DNMT1 Interactions in the Genome. PMID:34439147
Decoupling Lineage-Associated Genes in Acute Myeloid Leukemia Reveals Inflammatory and Metabolic Signatures Associated With Outcomes. PMID:34422660
Stem cell therapy: A paradigm shift in breast cancer treatment. PMID:34367480
Protein Arginine Methyltransferase 1 Is Essential for the Meiosis of Male Germ Cells. PMID:34360715
Pan-cancer analysis of non-coding recurrent mutations and their possible involvement in cancer pathogenesis. PMID:34316701
Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification. PMID:34307463
Sequencing of a central nervous system tumor demonstrates cancer transmission in an organ transplant. PMID:34301805
Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing. PMID:34301788
Web tools to perform long non-coding RNAs analysis in oncology research. PMID:34296748
KRAS gene status in gastric signet-ring cell carcinoma patients and acts as biomarker of MEK inhibitor. PMID:34295553
Chemopreventive effects of pterostilbene through p53 and cell cycle in mouse lung of squamous cell carcinoma model. PMID:34290382
Single Cell Genetic Profiling of Tumors of Breast Cancer Patients Aged 50 Years and Older Reveals Enormous Intratumor Heterogeneity Independent of Individual Prognosis. PMID:34282768
A preclinical report of a cobimetinib-inspired novel anticancer small-molecule scaffold of isoflavones, NSC777213, for targeting PI3K/AKT/mTOR/MEK in multiple cancers. PMID:34249417
Genomic and Transcriptome Analysis to Identify the Role of the mTOR Pathway in Kidney Renal Clear Cell Carcinoma and Its Potential Therapeutic Significance. PMID:34194607
Clinicopathological significance of the EMT-related proteins and their interrelationships in prostate cancer. An immunohistochemical study. PMID:34157052
MicroRNA-486-5p Suppresses Lung Cancer via Downregulating mTOR Signaling In Vitro and In Vivo. PMID:34094949
Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione. PMID:34088745
Current Understanding of Neurofibromatosis Type 1, 2, and Schwannomatosis. PMID:34072574
dbGENVOC: database of GENomic Variants of Oral Cancer, with special reference to India. PMID:34048545
Identification of combinations of somatic mutations that predict cancer survival and immunotherapy benefit. PMID:34027407
Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism. PMID:34016143
Differential Mutation Detection Capability Through Capture-Based Targeted Sequencing in Plasma Samples in Hepatocellular Carcinoma. PMID:33996539
Knowledge bases and software support for variant interpretation in precision oncology. PMID:33971666
Screening and identification of LMNB1 and DLGAP5, two key biomarkers in gliomas. PMID:33956061
Deletions in FLT-3 juxtamembrane domain define a new class of pathogenic mutations: case report and systematic analysis. PMID:33914060
Digital next-generation sequencing of cell-free DNA for pancreatic cancer. PMID:33860102
Impact of clinical targeted sequencing on endocrine responsiveness in estrogen receptor-positive, HER2-negative metastatic breast cancer. PMID:33854152
Comprehensive omic characterization of breast cancer in Mexican-Hispanic women. PMID:33854067
Panels and models for accurate prediction of tumor mutation burden in tumor samples. PMID:33850256
Emerging Role of ODC1 in Neurodevelopmental Disorders and Brain Development. PMID:33806076
Aging affects circadian clock and metabolism and modulates timing of medication. PMID:33796837
Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level. PMID:33747920
Comprehensive characterization of a drug-resistance-related ceRNA network across 15 anti-cancer drug categories. PMID:33738135
PLA1A expression as a diagnostic marker of BRAF-mutant metastasis in melanoma cancer. PMID:33723350
Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics. PMID:33664507
FAM83H-AS1 is a noncoding oncogenic driver and therapeutic target of lung adenocarcinoma. PMID:33634993
A synergetic effect of BARD1 mutations on tumorigenesis. PMID:33623049
Molecular Mechanisms of MYCN Dysregulation in Cancers. PMID:33614505
Mutant-selective degradation by BRAF-targeting PROTACs. PMID:33568647
Analysis of the role of Frizzled 2 in different cancer types. PMID:33565732
Distinct roles for the RNA-binding protein Staufen1 in prostate cancer. PMID:33541283
Medulloblastoma under Siege: Genetic and Molecular Dissection Concerning Recent Advances in Therapeutic Strategies. PMID:33531929
Machine learning applications in drug development. PMID:33489002
Discovery of a hidden transient state in all bromodomain families. PMID:33468647
Clinical significance of genetic alterations in endoscopically obtained pancreatic cancer specimens. PMID:33455072
A human surfactant B deficiency air-liquid interface cell culture model suitable for gene therapy applications. PMID:33426150
An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression. PMID:33423164
Interaction between Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1 and GTP-H-Ras: Implications for Aggressiveness of Human Mammary Epithelial Cells and Drug Resistance. PMID:33409256
DeMaSk: a deep mutational scanning substitution matrix and its use for variant impact prediction. PMID:33325500
Cross-Site Concordance Evaluation of Tumor DNA and RNA Sequencing Platforms for the CIMAC-CIDC Network. PMID:33323402
MitImpact 3: modeling the residue interaction network of the Respiratory Chain subunits. PMID:33300029
Influence of Cholesterol on the Orientation of the Farnesylated GTP-Bound KRas-4B Binding with Anionic Model Membranes. PMID:33266473
The Role of Autophagy in Liver Cancer: Crosstalk in Signaling Pathways and Potential Therapeutic Targets. PMID:33260729
Targeted nanopore sequencing by real-time mapping of raw electrical signal with UNCALLED. PMID:33257863
Mutation effects on charge transport through the p58c iron-sulfur protein. PMID:33250976
Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies. PMID:33229534
Structural bioinformatics enhances mechanistic interpretation of genomic variation, demonstrated through the analyses of 935 distinct RAS family mutations. PMID:33226070
LincSNP 3.0: an updated database for linking functional variants to human long non-coding RNAs, circular RNAs and their regulatory elements. PMID:33219661
Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Origin: Retrospective Molecular Classification Considering the CUPISCO Study Design. PMID:33219618
Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort. PMID:33168853
A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. PMID:33156843
Long-term single-cell passaging of human iPSC fully supports pluripotency and high-efficient trilineage differentiation capacity. PMID:33149912
Feature selection algorithm based on dual correlation filters for cancer-associated somatic variants. PMID:33121438
Fractionated small cell-free DNA increases possibility to detect cancer-related gene mutations in advanced colorectal cancer. PMID:33102773
Cutting the Brakes on Ras-Cytoplasmic GAPs as Targets of Inactivation in Cancer. PMID:33096593
Distinct genomic subclasses of high-grade/progressive meningiomas: NF2-associated, NF2-exclusive, and NF2-agnostic. PMID:33087175
Identification of hub genes and small molecule therapeutic drugs related to breast cancer with comprehensive bioinformatics analysis. PMID:33083112
Role of Cadherins in Cancer-A Review. PMID:33076339
Accuracy and reproducibility of somatic point mutation calling in clinical-type targeted sequencing data. PMID:33059707
PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective. PMID:33046444
KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors. PMID:32955176
Novel regulation of Ras proteins by direct tyrosine phosphorylation and dephosphorylation. PMID:32936431
Targeting the epigenetic regulation of antitumour immunity. PMID:32929243
Incorporating prior knowledge into regularized regression. PMID:32915960
CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. PMID:32883883
RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics. PMID:32797215
Small molecule inhibitors of RAS proteins with oncogenic mutations. PMID:32770300
Genomic, transcriptomic, and protein landscape profile of CFTR and cystic fibrosis. PMID:32734384
Activating PIK3CA mutation promotes adipogenesis of adipose-derived stem cells in macrodactyly via up-regulation of E2F1. PMID:32732866
MAGPEL: an autoMated pipeline for inferring vAriant-driven Gene PanEls from the full-length biomedical literature. PMID:32703994
A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19. PMID:32676577
Genomic assessment distinguishes intrapulmonary metastases from synchronous primary lung cancers. PMID:32642098
Decoding the evolutionary response to prostate cancer therapy by plasma genome sequencing. PMID:32631448
Clinical utility of target capture-based panel sequencing in hematological malignancies: A multicenter feasibility study. PMID:32619037
Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics. PMID:32549302
Update on GNA Alterations in Cancer: Implications for Uveal Melanoma Treatment. PMID:32532044
MicroRNA Signatures in Blood or Bone Marrow Distinguish Subtypes of Pediatric Acute Lymphoblastic Leukemia. PMID:32531485
Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes. PMID:32513296
Defined lifestyle and germline factors predispose Asian populations to gastric cancer. PMID:32426482
Mutation severity spectrum of rare alleles in the human genome is predictive of disease type. PMID:32413045
Clinicopathological Characteristics of PIK3CA Mutation and Amplification in Korean Patients with Breast Cancers. PMID:32410843
Form-Vessel Classification of Cholangioscopy Findings to Diagnose Biliary Tract Carcinoma's Superficial Spread. PMID:32392821
Liquid biopsy-based tumor profiling for metastatic colorectal cancer patients with ultra-deep targeted sequencing. PMID:32379795
The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors. PMID:32374727
RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K-RAS mutant tumors. PMID:32336014
Prognostic value of TP53 concurrent mutations for EGFR- TKIs and ALK-TKIs based targeted therapy in advanced non-small cell lung cancer: a meta-analysis. PMID:32299384
SAAMBE-3D: Predicting Effect of Mutations on Protein-Protein Interactions. PMID:32272725
Mutations in calmodulin-binding domains of TRPV4/6 channels confer invasive properties to colon adenocarcinoma cells. PMID:32186440
ATM-Deficient Cancers Provide New Opportunities for Precision Oncology. PMID:32183301
A decision tree to improve identification of pathogenic mutations in clinical practice. PMID:32151256
LeukmiR: a database for miRNAs and their targets in acute lymphoblastic leukemia. PMID:32128558
Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes. PMID:32101536
Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors. PMID:32099531
PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma. PMID:32075097
Genetic alterations related to endoscopic treatment of colorectal tumors. PMID:32055701
DEEPrior: a deep learning tool for the prioritization of gene fusions. PMID:32016382
KRAS G12C Game of Thrones, which direct KRAS inhibitor will claim the iron throne? PMID:32014824
The current understanding of KRAS protein structure and dynamics. PMID:31988705
Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy. PMID:31941155
Cancer progression is mediated by proline catabolism in non-small cell lung cancer. PMID:31911619
Amyloid Beta (A4) Precursor Protein: A Potential Biomarker for Recurrent Nasopharyngeal Carcinoma. PMID:31908537
A Germline Mutation in the C2 Domain of PLCγ2 Associated with Gain-of-Function Expands the Phenotype for PLCG2-Related Diseases. PMID:31853824
Evaluating the consistency of large-scale pharmacogenomic studies. PMID:31846027
A pan-cancer somatic mutation embedding using autoencoders. PMID:31829157
RAS, Cellular Plasticity, and Tumor Budding in Colorectal Cancer. PMID:31803624
Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. PMID:31759698
Ontology-based prediction of cancer driver genes. PMID:31757986
Mutation of the PTCH1 gene predicts recurrence of breast cancer. PMID:31704974
Establishment and Characterization of 10 Human Pancreatic Cancer Cell Lines Including a HER2 Overexpressed Cell Line. PMID:31688591
DrugCombDB: a comprehensive database of drug combinations toward the discovery of combinatorial therapy. PMID:31665429
Anti-Proliferative Effects of an Extra-Virgin Olive Oil Extract Enriched in Ligstroside Aglycone and Oleocanthal on Human Liver Cancer Cell Lines. PMID:31653043
Uncovering and characterizing splice variants associated with survival in lung cancer patients. PMID:31652257
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis. PMID:31649266
Establishment and characterization of novel patient-derived extraskeletal osteosarcoma cell line NCC-ESOS1-C1. PMID:31625124
Liquid biopsy: one cell at a time. PMID:31602399
β-Catenin mutations as determinants of hepatoblastoma phenotypes in mice. PMID:31597698
Epigenetic Mechanisms of Escape from BRAF Oncogene Dependency. PMID:31581557
Identification of targetable BRAF ΔN486_P490 variant by whole-genome sequencing leading to dabrafenib-induced remission of a BRAF-mutant pancreatic adenocarcinoma. PMID:31519698
Gastric cancer & prospects of cancer in Saudi Arabia peninsula. PMID:31516334
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. PMID:31515488
FunDMDeep-m6A: identification and prioritization of functional differential m6A methylation genes. PMID:31510685
Whole exome sequencing study of a Chinese concurrent cancer family. PMID:31452746
Influence of BRCA1 Germline Mutations in the Somatic Mutational Burden of Triple-Negative Breast Cancer. PMID:31419696
Concurrent TP53 mutations predict poor outcomes of EGFR-TKI treatments in Chinese patients with advanced NSCLC. PMID:31417310
Next-generation sequencing in liquid biopsy: cancer screening and early detection. PMID:31370908
Intrinsic GTPase Activity of K-RAS Monitored by Native Mass Spectrometry. PMID:31306575
Detection of a novel panel of somatic mutations in plasma cell-free DNA and its diagnostic value in hepatocellular carcinoma. PMID:31303788
A systematic approach to orient the human protein-protein interaction network. PMID:31289271
Somatic molecular analysis augments cytologic evaluation of pancreatic cyst fluids as a diagnostic tool. PMID:31258847
Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPKα signaling in STK11 mutant lung cancer. PMID:31232177
The role of mouse tumour models in the discovery and development of anticancer drugs. PMID:31231121
Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer. PMID:31201273
Total copy number variation as a prognostic factor in adult astrocytoma subtypes. PMID:31177992
Club cells form lung adenocarcinomas and maintain the alveoli of adult mice. PMID:31140976
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia. PMID:31085557
Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms. PMID:31064751
Systematic characterization of germline variants from the DiscovEHR study endometrial carcinoma population. PMID:31053132
CANCROX: a cross-species cancer therapy database. PMID:31032838
Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation. PMID:30991970
A Deep Learning Approach to the Screening of Oncogenic Gene Fusions in Humans. PMID:30987060
Simultaneous Interrogation of Cancer Omics to Identify Subtypes With Significant Clinical Differences. PMID:30984238
Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing. PMID:30942411
An Interactive Resource to Probe Genetic Diversity and Estimated Ancestry in Cancer Cell Lines. PMID:30894373
Enrichment of short mutant cell-free DNA fragments enhanced detection of pancreatic cancer. PMID:30857943
The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management. PMID:30854333
S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. PMID:30842656
Identification of enhancer of mRNA decapping 4 as a novel fusion partner of MLL in acute myeloid leukemia. PMID:30833276
A hybrid approach for automated mutation annotation of the extended human mutation landscape in scientific literature. PMID:30815103
Targeting epigenetics for cancer therapy. PMID:30806885
Non-invasive analysis of tumor mutation profiles and druggable mutations by sequencing of cell free DNA of Chinese metastatic breast cancer patients. PMID:30793491
Identification of early genetic changes in well-differentiated intramucosal gastric carcinoma by target deep sequencing. PMID:30756200
Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer. PMID:30755618
mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy. PMID:30754640
Feasibility and utility of a panel testing for 114 cancer-associated genes in a clinical setting: A hospital-based study. PMID:30742731
Network-guided prediction of aromatase inhibitor response in breast cancer. PMID:30742607
A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone. PMID:30670014
Characterization of human telomerase reverse transcriptase promoter methylation and transcription factor binding in differentiated thyroid cancer cell lines. PMID:30664813
Deletion of C9orf53 promotes the growth of head and neck squamous cell carcinoma and is associated with poor prognosis of patients with head and neck squamous cell carcinoma. PMID:30655888
Impact of p85α Alterations in Cancer. PMID:30650664
Biological Interpretation of Complex Genomic Data. PMID:30649721
Comparison of Cardiac miRNA Transcriptomes Induced by Diabetes and Rapamycin Treatment and Identification of a Rapamycin-Associated Cardiac MicroRNA Signature. PMID:30647817
Integration of cell of origin into the clinical CNS International Prognostic Index improves CNS relapse prediction in DLBCL. PMID:30617197
Genomic Landscape of Pancreatic Adenocarcinoma in Younger versus Older Patients: Does Age Matter? PMID:30617137
Chromatin regulatory mechanisms and therapeutic opportunities in cancer. PMID:30602726
VarQ: A Tool for the Structural and Functional Analysis of Human Protein Variants. PMID:30574164
NRAS Q61R and BRAF G466A mutations in atypical melanocytic lesions newly arising in advanced melanoma patients treated with vemurafenib. PMID:30552700
Monitoring BRAF and NRAS mutations with cell-free circulating tumor DNA from metastatic melanoma patients. PMID:30546839
Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer. PMID:30544563
OncoBase: a platform for decoding regulatory somatic mutations in human cancers. PMID:30445567
Transcriptomic Alterations in Lung Adenocarcinoma Unveil New Mechanisms Targeted by the TBX2 Subfamily of Tumor Suppressor Genes. PMID:30425966
Triptolide as a novel agent in pancreatic cancer: the validation using patient derived pancreatic tumor cell line. PMID:30419860
Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations. PMID:30412573
Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation. PMID:30406002
βcatenin is a marker of poor clinical characteristics and suppressed immune infiltration in testicular germ cell tumors. PMID:30390643
Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis. PMID:30384176
Development and validation of the PEPPER framework (Prenatal Exposure PubMed ParsER) with applications to food additives. PMID:30371821
Metformin reverses the resistance mechanism of lung adenocarcinoma cells that knocks down the Nrf2 gene. PMID:30333878
Synthetic Circular RNA Functions as a miR-21 Sponge to Suppress Gastric Carcinoma Cell Proliferation. PMID:30326427
RAS variant signalling. PMID:30287508
Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice. PMID:30273559
Antitumor activity of sorafenib plus CDK4/6 inhibitor in pancreatic patient derived cell with KRAS mutation. PMID:30271501
Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity. PMID:30243563
Bacterial endosymbiont Cardinium cSfur genome sequence provides insights for understanding the symbiotic relationship in Sogatella furcifera host. PMID:30231855
Reviving oncogenic addiction to MET bypassed by BRAF (G469A) mutation. PMID:30224486
PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas. PMID:30194764
The biological and clinical challenge of liver cancer heterogeneity. PMID:30190968
NRAS mutant melanoma: an overview for the clinician for melanoma management. PMID:30190872
A phase I study of the farnesyltransferase inhibitor Tipifarnib in combination with the epidermal growth factor tyrosine kinase inhibitor Erlotinib in patients with advanced solid tumors. PMID:30171497
Analytical Validation of Clinical Whole-Genome and Transcriptome Sequencing of Patient-Derived Tumors for Reporting Targetable Variants in Cancer. PMID:30138725
Thyroid cancers of follicular origin in a genomic light: in-depth overview of common and unique molecular marker candidates. PMID:30089490
Genomic Profiling of T-Cell Neoplasms Reveals Frequent JAK1 and JAK3 Mutations With Clonal Evasion From Targeted Therapies. PMID:30079384
INBIA: a boosting methodology for proteomic network inference. PMID:30066650
A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma. PMID:30042422
Clonal diversity predicts adverse outcome in chronic lymphocytic leukemia. PMID:30038380
Computational Approaches to Prioritize Cancer Driver Missense Mutations. PMID:30037003
Genomic alterations accompanying tumour evolution in colorectal cancer: tracking the differences between primary tumours and synchronous liver metastases by whole-exome sequencing. PMID:30029640
Sirt1 protects from K-Ras-driven lung carcinogenesis. PMID:30021836
Description of Genetic Variants in BRCA Genes in Mexican Patients with Ovarian Cancer: A First Step towards Implementing Personalized Medicine. PMID:29997359
Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal. PMID:29991556
Combining Pathway Identification and Breast Cancer Survival Prediction via Screening-Network Methods. PMID:29963073
Complexes formed by mutant p53 and their roles in breast cancer. PMID:29950894
Cancer panel analysis of circulating tumor cells in patients with breast cancer. PMID:29928447
The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy. PMID:29928381
Integrative Genome-Wide Analysis of Long Noncoding RNAs in Diverse Immune Cell Types of Melanoma Patients. PMID:29895674
Deep sequencing of human papillomavirus positive loco-regionally advanced oropharyngeal squamous cell carcinomas reveals novel mutational signature. PMID:29879932
Computational modeling of methionine cycle-based metabolism and DNA methylation and the implications for anti-cancer drug response prediction. PMID:29875994
SB Driver Analysis: a Sleeping Beauty cancer driver analysis framework for identifying and prioritizing experimentally actionable oncogenes and tumor suppressors. PMID:29846651
Multiplexed enrichment of rare DNA variants via sequence-selective and temperature-robust amplification. PMID:29805844
Measuring coverage and accuracy of whole-exome sequencing in clinical context. PMID:29789557
Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy. PMID:29781349
mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis Complex Model. PMID:29772672
PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis. PMID:29769245
SNPnexus: assessing the functional relevance of genetic variation to facilitate the promise of precision medicine. PMID:29757393
Genetic and Epigenetic Features of Rapidly Progressing IDH-Mutant Astrocytomas. PMID:29741737
Genome sequencing in the clinic: the past, present, and future of genomic medicine. PMID:29727589
PIK3CA mutation, reduced AKT serine 473 phosphorylation, and increased ERα serine 167 phosphorylation are positive prognostic indicators in postmenopausal estrogen receptor-positive early breast cancer. PMID:29707142
Mutational profiling can identify laryngeal dysplasia at risk of progression to invasive carcinoma. PMID:29700339
System for Informatics in the Molecular Pathology Laboratory: An Open-Source End-to-End Solution for Next-Generation Sequencing Clinical Data Management. PMID:29698836
β-Catenin-driven adrenocortical carcinoma is characterized with immune exclusion. PMID:29670378
IDH1 mutation is associated with lower expression of VEGF but not microvessel formation in glioblastoma multiforme. PMID:29662659
Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers. PMID:29641532
Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. PMID:29622466
A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers. PMID:29622464
Finding cancer driver mutations in the era of big data research. PMID:29611034
Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin. PMID:29610390
Inhibition of PI3K/AKT Signaling Pathway Radiosensitizes Pancreatic Cancer Cells with ARID1A Deficiency in Vitro. PMID:29581767
Single nucleotide variant profiles of viable single circulating tumour cells reveal CTC behaviours in breast cancer. PMID:29565466
Precision oncology in advanced cancer patients improves overall survival with lower weekly healthcare costs. PMID:29552312
Selenium-binding protein 1 is down-regulated in malignant melanoma. PMID:29535818
Identification of differentially expressed genes and biological pathways in bladder cancer. PMID:29532898
Prediction of sensitivity to gefitinib/erlotinib for EGFR mutations in NSCLC based on structural interaction fingerprints and multilinear principal component analysis. PMID:29514601
Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening. PMID:29503867
Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma. PMID:29497050
A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells. PMID:29491475
The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis. PMID:29463063
Selective identification of somatic mutations in pancreatic cancer cells through a combination of next-generation sequencing of plasma DNA using molecular barcodes and a bioinformatic variant filter. PMID:29451897
Assessment of a new genomic classification system in acute myeloid leukemia with a normal karyotype. PMID:29435155
Notch signaling via regulation of RB and p-AKT but not PIK3CG contributes to MIA PaCa-2 cell growth and migration to affect pancreatic carcinogenesis. PMID:29434912
Copy number profiles of paired primary and metastatic colorectal cancers. PMID:29423054
A computational approach to distinguish somatic vs. germline origin of genomic alterations from deep sequencing of cancer specimens without a matched normal. PMID:29415044
OneD: increasing reproducibility of Hi-C samples with abnormal karyotypes. PMID:29394371
Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. PMID:29374058
Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy. PMID:29357370
Interactome INSIDER: a structural interactome browser for genomic studies. PMID:29355848
Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival. PMID:29354286
mTOR Cross-Talk in Cancer and Potential for Combination Therapy. PMID:29351204
The Prognostic Value of HRAS mRNA Expression in Cutaneous Melanoma. PMID:29349077
The eIF4E2-Directed Hypoxic Cap-Dependent Translation Machinery Reveals Novel Therapeutic Potential for Cancer Treatment. PMID:29317983
Posttranslational Modifications of RAS Proteins. PMID:29311131
Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression. PMID:29301334
MicroRNA-128 suppresses paclitaxel-resistant lung cancer by inhibiting MUC1-C and BMI-1 in cancer stem cells. PMID:29299167
Identification of the genetic and clinical characteristics of neuroblastomas using genome-wide analysis. PMID:29296183
Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines. PMID:29228706
Exome sequencing characterizes the somatic mutation spectrum of early serrated lesions in a patient with serrated polyposis syndrome (SPS). PMID:29213343
MicroRNA regulation of K-Ras in pancreatic cancer and opportunities for therapeutic intervention. PMID:29199014
Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins. PMID:29165587
Activating FGFR1 Mutations in Sporadic Pheochromocytomas. PMID:29159601
An analysis of the gene interaction networks identifying the role of PARP1 in metastasis of non-small cell lung cancer. PMID:29152079
Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib. PMID:29152062
Copy number gains at chr3p25 and chr11p11 are associated with lymph node involvement and survival in muscle-invasive bladder tumors. PMID:29140994
CRTC2 promotes non-small cell lung cancer A549 migration and invasion in vitro. PMID:29105369
"Personalized Cancer Therapy": A Publicly Available Precision Oncology Resource. PMID:29092956
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors. PMID:29089486
Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. PMID:29089421
Noncoding Variants Functional Prioritization Methods Based on Predicted Regulatory Factor Binding Sites. PMID:29081688
lncRNASNP2: an updated database of functional SNPs and mutations in human and mouse lncRNAs. PMID:29077939
Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. PMID:29033317
Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells. PMID:29028794
Systematic, network-based characterization of therapeutic target inhibitors. PMID:29023443
Reconstructing cancer drug response networks using multitask learning. PMID:29017547
Colorectal Cancer Screening: A Comprehensive Review to Recent Non-Invasive Methods. PMID:28989593
Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. PMID:28988769
Base-resolution stratification of cancer mutations using functional variomics. PMID:28981122
Identification of Linkages between EDCs in Personal Care Products and Breast Cancer through Data Integration Combined with Gene Network Analysis. PMID:28973975
Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B. PMID:28968425
Next-Generation Sequencing in the Clinical Setting Clarifies Patient Characteristics and Potential Actionability. PMID:28939679
Mutation-profile-based methods for understanding selection forces in cancer somatic mutations: a comparative analysis. PMID:28938601
VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy. PMID:28931371
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy. PMID:28854171
PI3K: A Crucial Piece in the RAS Signaling Puzzle. PMID:28847905
Multitype Network-Guided Target Controllability in Phenotypically Characterized Osteosarcoma: Role of Tumor Microenvironment. PMID:28824643
An Optimal Mean Based Block Robust Feature Extraction Method to Identify Colorectal Cancer Genes with Integrated Data. PMID:28819308
Leveraging network analytics to infer patient syndrome and identify causal genes in rare disease cases. PMID:28812537
Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma. PMID:28776573
Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types. PMID:28743916
The impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer. PMID:28742836
Comparing sequencing assays and human-machine analyses in actionable genomics for glioblastoma. PMID:28740869
Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency. PMID:28726391
Association Of Plasma And Urinary Mutant DNA With Clinical Outcomes In Muscle Invasive Bladder Cancer. PMID:28717136
Identification of trunk mutations in gastric carcinoma: a case study. PMID:28716121
Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth. PMID:28709411
Two different, mutually exclusively distributed, TP53 mutations in ovarian and peritoneal tumor tissues of a serous ovarian cancer patient: indicative for tumor origin? PMID:28679689
Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF. PMID:28676500
Precision medicine based on epigenomics: the paradigm of carcinoma of unknown primary. PMID:28675165
A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay. PMID:28649990
High-confidence assessment of functional impact of human mitochondrial non-synonymous genome variations by APOGEE. PMID:28640805
Performance of four modern whole genome amplification methods for copy number variant detection in single cells. PMID:28611458
Systematic Quantification of Population Cell Death Kinetics in Mammalian Cells. PMID:28601558
Gene Therapy for Pancreatic Cancer: Specificity, Issues and Hopes. PMID:28594388
A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data. PMID:28569218
Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations. PMID:28515055
Treatment inferred from mutations identified using massive parallel sequencing leads to clinical benefit in some heavily pretreated cancer patients. PMID:28514312
Characterization of genetic aberrations in a single case of metastatic thymic adenocarcinoma. PMID:28506304
Comprehensive Genomic Profiling of Esthesioneuroblastoma Reveals Additional Treatment Options. PMID:28495808
Cancer-Associated Mutations in Endometriosis without Cancer. PMID:28489996
Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumor cells. PMID:28487279
MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer. PMID:28466200
Correlation between epidermal growth factor receptor mutations and the expression of estrogen receptor-β in advanced non-small cell lung cancer. PMID:28454404
A comprehensive analysis of cancer-driving mutations and genes in kidney cancer. PMID:28454375
WDR23 regulates NRF2 independently of KEAP1. PMID:28453520
Ultra-specific discrimination of single-nucleotide mutations using sequestration-assisted molecular beacons. PMID:28451240
Mining Exosomal Genes for Pancreatic Cancer Targets. PMID:28446531
PathOS: a decision support system for reporting high throughput sequencing of cancers in clinical diagnostic laboratories. PMID:28438193
Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples. PMID:28426665
Reciprocal control of lncRNA-BCAT1 and β-catenin pathway reveals lncRNA-BCAT1 long non-coding RNA acts as a tumor suppressor in colorectal cancer. PMID:28416735
Network Analysis Reveals A Signaling Regulatory Loop in the PIK3CA-mutated Breast Cancer Predicting Survival Outcome. PMID:28392480
Emerging role of mutations in epigenetic regulators including MLL2 derived from The Cancer Genome Atlas for cervical cancer. PMID:28390392
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival. PMID:28387924
Tissue-Specific Signaling Networks Rewired by Major Somatic Mutations in Human Cancer Revealed by Proteome-Wide Discovery. PMID:28364002
Pysim-sv: a package for simulating structural variation data with GC-biases. PMID:28361688
TP53 and RET may serve as biomarkers of prognostic evaluation and targeted therapy in hepatocellular carcinoma. PMID:28350084
Functional variomics and network perturbation: connecting genotype to phenotype in cancer. PMID:28344341
Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells. PMID:28344327
High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation. PMID:28330874
A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. PMID:28320739
Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies. PMID:28292435
Network Biomarkers Constructed from Gene Expression and Protein-Protein Interaction Data for Accurate Prediction of Leukemia. PMID:28243332
The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond. PMID:28237819
The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport. PMID:28232525
Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies. PMID:28231819
Single-Nucleotide Polymorphism of PPARγ, a Protein at the Crossroads of Physiological and Pathological Processes. PMID:28208577
Molecular modeling in the age of clinical genomics, the enterprise of the next generation. PMID:28204942
Integrated genomic analyses of de novo pathways underlying atypical meningiomas. PMID:28195122
Annotating Mutational Effects on Proteins and Protein Interactions: Designing Novel and Revisiting Existing Protocols. PMID:28188534
Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing. PMID:28182693
Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding. PMID:28180316
KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1. PMID:28180290
Distribution bias analysis of germline and somatic single-nucleotide variations that impact protein functional site and neighboring amino acids. PMID:28176830
Specific and Efficient Regression of Cancers Harboring KRAS Mutation by Targeted RNA Replacement. PMID:28153088
The use of gene interaction networks to improve the identification of cancer driver genes. PMID:28149674
DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer. PMID:28120820
A comprehensive global genotype-phenotype database for rare diseases. PMID:28116331
Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing. PMID:28091594
Single genome retrieval of context-dependent variability in mutation rates for human germline. PMID:28086752
Common risk variants for colorectal cancer: an evaluation of associations with age at cancer onset. PMID:28084440
Detection of KRAS Mutations in Plasma DNA Using a fully Automated Rapid Detection System in Colorectal Cancer Patients. PMID:28058585
Individual Bromodomains of Polybromo-1 Contribute to Chromatin Association and Tumor Suppression in Clear Cell Renal Carcinoma. PMID:28053089
Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine. PMID:28049532
Kinase impact assessment in the landscape of fusion genes that retain kinase domains: a pan-cancer study. PMID:28013235
Germline compound heterozygous poly-glutamine deletion in USF3 may be involved in predisposition to heritable and sporadic epithelial thyroid carcinoma. PMID:28011713
iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing driver genes in personal cancer genomes. PMID:28007024
Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation. PMID:28002804
Antimutagenic Effects of Selenium-Enriched Polysaccharides from Pyracantha fortuneana through Suppression of Cytochrome P450 1A Subfamily in the Mouse Liver. PMID:27999293
Choosing the right cell line for renal cell cancer research. PMID:27993170
BFDCA: A Comprehensive Tool of Using Bayes Factor for Differential Co-Expression Analysis. PMID:27984044
CanProVar 2.0: An Updated Database of Human Cancer Proteome Variation. PMID:27977206
Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes. PMID:27939638
Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase. PMID:27936599
Concordance between somatic copy number loss and down-regulated expression: A pan-cancer study of cancer predisposition genes. PMID:27929028
Evaluating the evaluation of cancer driver genes. PMID:27911828
Prioritization of non-coding disease-causing variants and long non-coding RNAs in liver cancer. PMID:27895760
Vertical Magnetic Separation of Circulating Tumor Cells for Somatic Genomic-Alteration Analysis in Lung Cancer Patients. PMID:27892470
A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease. PMID:27863505
Comprehensive screening of target molecules by next-generation sequencing in patients with malignant solid tumors: guiding entry into phase I clinical trials. PMID:27852271
K-ras oncogene mutation in pterygium. PMID:27834959
Investigating genetic characteristics of hepatitis B virus-associated and -non-associated hepatocellular carcinoma. PMID:27834158
A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma. PMID:27821489
A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. PMID:27799065
Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms. PMID:27790711
Technological considerations for genome-guided diagnosis and management of cancer. PMID:27784341
Genomic heterogeneity of multiple synchronous lung cancer. PMID:27767028
Chromatin accessibility contributes to simultaneous mutations of cancer genes. PMID:27762310
Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas. PMID:27738081
Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies. PMID:27713118
K-Ras Activation Induces Differential Sensitivity to Sulfur Amino Acid Limitation and Deprivation and to Oxidative and Anti-Oxidative Stress in Mouse Fibroblasts. PMID:27685888
Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells. PMID:27681615
90K Glycoprotein Promotes Degradation of Mutant β-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus. PMID:27668402
LPRP: A Gene-Gene Interaction Network Construction Algorithm and Its Application in Breast Cancer Data Analysis. PMID:27640171
mTOR inhibitors in cancer therapy. PMID:27635236
Systems Biology-Based Investigation of Cellular Antiviral Drug Targets Identified by Gene-Trap Insertional Mutagenesis. PMID:27632082
YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer. PMID:27627196
Unsupervised detection of cancer driver mutations with parsimony-guided learning. PMID:27618449
EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer. PMID:27612429
A Retrospective Analysis of Precision Medicine Outcomes in Patients With Advanced Cancer Reveals Improved Progression-Free Survival Without Increased Health Care Costs. PMID:27601506
Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes. PMID:27600516
Characterizing and targeting PDGFRA alterations in pediatric high-grade glioma. PMID:27582545
Minireview: The Link Between ERα Corepressors and Histone Deacetylases in Tamoxifen Resistance in Breast Cancer. PMID:27581354
Comprehensive characterization of lncRNA-mRNA related ceRNA network across 12 major cancers. PMID:27580177
Establishment and molecular characterisation of seven novel soft-tissue sarcoma cell lines. PMID:27560552
Elucidating Genomic Characteristics of Lung Cancer Progression from In Situ to Invasive Adenocarcinoma. PMID:27545006
Prevalent Accumulation of Non-Optimal Codons through Somatic Mutations in Human Cancers. PMID:27513638
SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling. PMID:27503857
Presence of both alterations in FGFR/FGF and PI3K/AKT/mTOR confer improved outcomes for patients with metastatic breast cancer treated with PI3K/AKT/mTOR inhibitors. PMID:27489863
Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer. PMID:27481051
FocalScan: Scanning for altered genes in cancer based on coordinated DNA and RNA change. PMID:27474725
Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design. PMID:27469033
Validation of a multi-omics strategy for prioritizing personalized candidate driver genes. PMID:27469031
Single-strand DNA library preparation improves sequencing of formalin-fixed and paraffin-embedded (FFPE) cancer DNA. PMID:27463017
The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine. PMID:27460824
Ranking novel cancer driving synthetic lethal gene pairs using TCGA data. PMID:27438146
Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability. PMID:27403962
Integrative radiogenomic analysis for genomic signatures in glioblastomas presenting leptomeningeal dissemination. PMID:27399113
RUBIC identifies driver genes by detecting recurrent DNA copy number breaks. PMID:27396759
Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view. PMID:27396271
Deciphering and Targeting Oncogenic Mutations and Pathways in Breast Cancer. PMID:27384237
BcCluster: A Bladder Cancer Database at the Molecular Level. PMID:27376128
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. PMID:27374120
The role of enhancers in cancer. PMID:27364481
Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia. PMID:27358048
Establishing and validating regulatory regions for variant annotation and expression analysis. PMID:27357948
Functional annotation of noncoding variants and prioritization of cancer-associated lncRNAs in lung cancer. PMID:27347129
CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma. PMID:27325650
Functional characterization of somatic mutations in cancer using network-based inference of protein activity. PMID:27322546
Novel targets for ATM-deficient malignancies. PMID:27308314
Identification of a region in the coiled-coil domain of Smc3 that is essential for cohesin activity. PMID:27307603
Genome-wide characterization of human L1 antisense promoter-driven transcripts. PMID:27301971
Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine. PMID:27296290
The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes. PMID:27282351
Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia. PMID:27282254
The Ensembl Variant Effect Predictor. PMID:27268795
Purifying selection shapes the coincident SNP distribution of primate coding sequences. PMID:27255481
Data integration to prioritize drugs using genomics and curated data. PMID:27231484
Reproducible pharmacogenomic profiling of cancer cell line panels. PMID:27193678
dbCPG: A web resource for cancer predisposition genes. PMID:27192119
Patient-specific factors influence somatic variation patterns in von Hippel-Lindau disease renal tumours. PMID:27174753
Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway. PMID:27152455
Molecular etiology of an indolent lymphoproliferative disorder determined by whole-genome sequencing. PMID:27148583
Gnaq and Gna11 in the Endothelin Signaling Pathway and Melanoma. PMID:27148356
The third dimension: new developments in cell culture models for colorectal research. PMID:27147463
Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling. PMID:27129147
Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype. PMID:27119498
Hepatitis C Virus Protein Interaction Network Analysis Based on Hepatocellular Carcinoma. PMID:27115606
PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma. PMID:27100670
DiMeX: A Text Mining System for Mutation-Disease Association Extraction. PMID:27073839
Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance. PMID:27071091
Ubiquitin-specific peptidase 22 functions and its involvement in disease. PMID:27057639
Proteogenomics: Integrating Next-Generation Sequencing and Mass Spectrometry to Characterize Human Proteomic Variation. PMID:27049631
Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy. PMID:27034805
Routine clinical mutation profiling using next generation sequencing and a customized gene panel improves diagnostic precision in myeloid neoplasms. PMID:27029036
Copy number deletion of RAD50 as predictive marker of BRCAness and PARP inhibitor response in BRCA wild type ovarian cancer. PMID:27016230
Contextualizing the Genes Altered in Bladder Neoplasms in Pediatric andTeen Patients Allows Identifying Two Main Classes of Biological ProcessesInvolved and New Potential Therapeutic Targets. PMID:27013923
KRAS G12D Mutation Subtype Is A Prognostic Factor for Advanced Pancreatic Adenocarcinoma. PMID:27010960
The importance of p53 pathway genetics in inherited and somatic cancer genomes. PMID:27009395
dbWGFP: a database and web server of human whole-genome single nucleotide variants and their functional predictions. PMID:26989155
CSCdb: a cancer stem cells portal for markers, related genes and functional information. PMID:26989154
Developments in miRNA gene signaling pathways in pancreatic cancer. PMID:26984178
MTDH genetic variants in colorectal cancer patients. PMID:26983693
FAK and paxillin, two potential targets in pancreatic cancer. PMID:26980710
Mutational status of synchronous and metachronous tumor samples in patients with metastatic non-small-cell lung cancer. PMID:26968843
Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases. PMID:26968808
Genome and network visualization facilitates the analyses of the effects of drugs and mutations on protein-protein and drug-protein networks. PMID:26961139
NGS meta data analysis for identification of SNP and INDEL patterns in human airway transcriptome: A preliminary indicator for lung cancer. PMID:26937342
Gene Variant Databases and Sharing: Creating a Global Genomic Variant Database for Personalized Medicine. PMID:26931283
KRAS, BRAF, and PIK3CA mutations, and patient prognosis in 126 pancreatic cancers: pyrosequencing technology and literature review. PMID:26927447
Mutational Landscape of Aggressive Prostate Tumors in African American Men. PMID:26921337
Genomic mapping of pathways in endometrial adenocarcinoma and a gastrointestinal stromal tumor located in Meckel's diverticulum. PMID:26893683
The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selection. PMID:26883632
Collateral Lethality: A new therapeutic strategy in oncology. PMID:26870836
Expression, purification, crystallization and X-ray data collection for RAS and its mutants. PMID:26866052
Mutation pattern is an influential factor on functional mutation rates in cancer. PMID:26865835
ApoCanD: Database of human apoptotic proteins in the context of cancer. PMID:26861916
A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1. PMID:26860615
LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer. PMID:26860319
mutation3D: Cancer Gene Prediction Through Atomic Clustering of Coding Variants in the Structural Proteome. PMID:26841357
Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation. PMID:26804919
Amplification-free in situ KRAS point mutation detection at 60 copies per mL in urine in a background of 1000-fold wild type. PMID:26783561
AURA 2: Empowering discovery of post-transcriptional networks. PMID:26779400
dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. PMID:26777304
Kinase Inhibitor Profiling Reveals Unexpected Opportunities to Inhibit Disease-Associated Mutant Kinases. PMID:26776524
Identification of mutant genes with high-frequency, high-risk, and high-expression in lung adenocarcinoma. PMID:26767003
Germline BAP1 mutations misreported as somatic based on tumor-only testing. PMID:26748926
A Distributed Network for Intensive Longitudinal Monitoring in Metastatic Triple-Negative Breast Cancer. PMID:26733551
Whole exome sequencing reveals a C-terminal germline variant in CEBPA-associated acute myeloid leukemia: 45-year follow up of a large family. PMID:26721895
The Prognostic Value of Microsatellite Instability, KRAS, BRAF and PIK3CA Mutations in Stage II Colon Cancer Patients. PMID:26716438
Identification of epistatic interactions through genome-wide association studies in sporadic medullary and juvenile papillary thyroid carcinomas. PMID:26690675
Expression, Epigenetic and Genetic Changes of HNF1B in Endometrial Lesions. PMID:26685938
Network-Based Integration of Disparate Omic Data To Identify "Silent Players" in Cancer. PMID:26683094
Balancing Protein Stability and Activity in Cancer: A New Approach for Identifying Driver Mutations Affecting CBL Ubiquitin Ligase Activation. PMID:26676746
TP53 Mutational Analysis Enhances the Prognostic Accuracy of IHC4 and PAM50 Assays. PMID:26671300
Mutation Screening of 1,237 Cancer Genes across Six Model Cell Lines of Basal-Like Breast Cancer. PMID:26670335
KRAS mutant lung cancer: progress thus far on an elusive therapeutic target. PMID:26668062
Systematic Prioritization of Druggable Mutations in ∼5000 Genomes Across 16 Cancer Types Using a Structural Genomics-based Approach. PMID:26657081
Differential regulation and synthetic lethality of exclusive RB1 and CDKN2A mutations in lung cancer. PMID:26647789
MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours. PMID:26635203
Improved Classification of Lung Cancer Using Radial Basis Function Neural Network with Affine Transforms of Voss Representation. PMID:26625358
Sequencing study on familial lung squamous cancer. PMID:26622902
Integrated genomic characterization of IDH1-mutant glioma malignant progression. PMID:26618343
Analytical Validation and Application of a Targeted Next-Generation Sequencing Mutation-Detection Assay for Use in Treatment Assignment in the NCI-MPACT Trial. PMID:26602013
The mathematics of cancer: integrating quantitative models. PMID:26597528
A Dual Model for Prioritizing Cancer Mutations in the Non-coding Genome Based on Germline and Somatic Events. PMID:26588488
Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer. PMID:26587011
Cooperation of BRAF(F595L) and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling. PMID:26582644
Whole Exome Sequencing of Rapid Autopsy Tumors and Xenograft Models Reveals Possible Driver Mutations Underlying Tumor Progression. PMID:26555578
Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma. PMID:26554828
Human genotype-phenotype databases: aims, challenges and opportunities. PMID:26553330
Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. PMID:26553052
Mutations in the transcriptional repressor REST predispose to Wilms tumor. PMID:26551668
Classification of Cancer Primary Sites Using Machine Learning and Somatic Mutations. PMID:26539502
A course-based undergraduate research experience investigating p300 bromodomain mutations. PMID:26537758
SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets. PMID:26516187
SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation. PMID:26511642
Discovery and functional characterization of a neomorphic PTEN mutation. PMID:26504226
Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. PMID:26503472
Circulating tumor cells (Ctc) and kras mutant circulating free Dna (cfdna) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer. PMID:26498594
Interpreting functional effects of coding variants: challenges in proteome-scale prediction, annotation and assessment. PMID:26494363
Big Data: the challenge for small research groups in the era of cancer genomics. PMID:26492224
Oncogenomic portals for the visualization and analysis of genome-wide cancer data. PMID:26484415
Continuously tunable nucleic acid hybridization probes. PMID:26480474
Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma. PMID:26477306
Somatic human ZBTB7A zinc finger mutations promote cancer progression. PMID:26455326
Targeting tumor suppressor genes for cancer therapy. PMID:26445307
Intron retention is a widespread mechanism of tumor-suppressor inactivation. PMID:26437032
Systematic analysis of somatic mutations impacting gene expression in 12 tumour types. PMID:26436532
Cell line name recognition in support of the identification of synthetic lethality in cancer from text. PMID:26428294
Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression. PMID:26424407
MGDB: a comprehensive database of genes involved in melanoma. PMID:26424083
Structural analysis of tumor-related single amino acid mutations in human MxA protein. PMID:26411585
Comprehensive assessment of cancer missense mutation clustering in protein structures. PMID:26392535
Kinome-wide decoding of network-attacking mutations rewiring cancer signaling. PMID:26388441
Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage. PMID:26378048
Novel endogenous angiogenesis inhibitors and their therapeutic potential. PMID:26364800
A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types. PMID:26352260
Identification of an oncogenic RAB protein. PMID:26338797
Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences. PMID:26336083
How do oncoprotein mutations rewire protein-protein interaction networks? PMID:26325016
Anatomy of protein disorder, flexibility and disease-related mutations. PMID:26322316
Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling. PMID:26317215
The distribution of BRAF gene fusions in solid tumors and response to targeted therapy. PMID:26314551
Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells. PMID:26300989
Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes. PMID:26300000
Use of semantic workflows to enhance transparency and reproducibility in clinical omics. PMID:26289940
Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination. PMID:26286987
Harmful somatic amino acid substitutions affect key pathways in cancers. PMID:26282678
What is the Need for Prostatic Biomarkers in Prostate Cancer Management? PMID:26267226
Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets. PMID:26261215
Cancer Cell Line Panels Empower Genomics-Based Discovery of Precision Cancer Medicine. PMID:26256959
HER2 activating mutations are targets for colorectal cancer treatment. PMID:26243863
Bioinformatic Challenges in Clinical Diagnostic Application of Targeted Next Generation Sequencing: Experience from Pheochromocytoma. PMID:26230854
Predicting the combined effect of multiple genetic variants. PMID:26223264
FusionCancer: a database of cancer fusion genes derived from RNA-seq data. PMID:26215638
Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning. PMID:26213851
Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity. PMID:26212640
Discriminating somatic and germline mutations in tumor DNA samples without matching normals. PMID:26209359
Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner. PMID:26206087
Chromosomal Rearrangements in Cancer: Detection and potential causal mechanisms. PMID:26203462
Rational Manual and Automated Scoring Thresholds for the Immunohistochemical Detection of TP53 Missense Mutations in Human Breast Carcinomas. PMID:26200835
Paired exome analysis of Barrett's esophagus and adenocarcinoma. PMID:26192918
Phenolyzer: phenotype-based prioritization of candidate genes for human diseases. PMID:26192085
Genetic architecture of colorectal cancer. PMID:26187503
Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial. PMID:26184520
Identification of Ohnolog Genes Originating from Whole Genome Duplication in Early Vertebrates, Based on Synteny Comparison across Multiple Genomes. PMID:26181593
Correlating bladder cancer risk genes with their targeting microRNAs using MMiRNA-Tar. PMID:26169799
Graph Curvature for Differentiating Cancer Networks. PMID:26169480
TD-60 links RalA GTPase function to the CPC in mitosis. PMID:26158537
Genome Modeling System: A Knowledge Management Platform for Genomics. PMID:26158448
TCF21 hypermethylation in genetically quiescent clear cell sarcoma of the kidney. PMID:26158413
Regulation rewiring analysis reveals mutual regulation between STAT1 and miR-155-5p in tumor immunosurveillance in seven major cancers. PMID:26156524
Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients. PMID:26154128
Novel scripts for improved annotation and selection of variants from whole exome sequencing in cancer research. PMID:26150983
Advanced Proteogenomic Analysis Reveals Multiple Peptide Mutations and Complex Immunoglobulin Peptides in Colon Cancer. PMID:26139413
Integrative network analysis for survival-associated gene-gene interactions across multiple genomic profiles in ovarian cancer. PMID:26138921
Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α. PMID:26122737
Mouse models of colorectal cancer as preclinical models. PMID:26115037
Disease-associated variants in different categories of disease located in distinct regulatory elements. PMID:26110593
Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis? PMID:26106140
Simulation-guided DNA probe design for consistently ultraspecific hybridization. PMID:26100802
An integrated approach to reveal miRNAs' impacts on the functional consequence of copy number alterations in cancer. PMID:26099552
Morphologic and Molecular Characteristics of Mixed Epithelial Ovarian Cancers. PMID:26099008
Comprehensive review of BAP1 tumor predisposition syndrome with report of two new cases. PMID:26096145
Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex. PMID:26095772
Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma. PMID:26087193
Approaches of targeting Rho GTPases in cancer drug discovery. PMID:26087073
Combined Targeted DNA Sequencing in Non-Small Cell Lung Cancer (NSCLC) Using UNCseq and NGScopy, and RNA Sequencing Using UNCqeR for the Detection of Genetic Aberrations in NSCLC. PMID:26076459
Pedican: an online gene resource for pediatric cancers with literature evidence. PMID:26073932
RAS Mutations Beyond KRAS Exon 2: A Review and Discussion of Clinical Trial Data. PMID:26050230
Integrative network-based approach identifies key genetic elements in breast invasive carcinoma. PMID:26040466
Genetics of the neuronal ceroid lipofuscinoses (Batten disease). PMID:26026925
A mass spectrometry-based method for comprehensive quantitative determination of post-transcriptional RNA modifications: the complete chemical structure of Schizosaccharomyces pombe ribosomal RNAs. PMID:26013808
Spatial genomic heterogeneity within localized, multifocal prostate cancer. PMID:26005866
Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy. PMID:26004768
The CREB Coactivator CRTC2 Is a Lymphoma Tumor Suppressor that Preserves Genome Integrity through Transcription of DNA Mismatch Repair Genes. PMID:26004186
Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma. PMID:26000094
Analysis of RAS mutation and PAX8/PPARγ rearrangements in follicular-derived thyroid neoplasms in a Korean population: frequency and ultrasound findings. PMID:25999051
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies. PMID:25997541
Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor. PMID:25995385
OncoRep: an n-of-1 reporting tool to support genome-guided treatment for breast cancer patients using RNA-sequencing. PMID:25989980
Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms. PMID:25986173
Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. PMID:25985179
Adaptation of peroxisome proliferator-activated receptor alpha to hibernation in bats. PMID:25980933
Genetic alterations of JAK/STAT cascade and histone modification in extranodal NK/T-cell lymphoma nasal type. PMID:25980440
Deubiquitinases in cancer. PMID:25972356
Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors. PMID:25970771
Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib. PMID:25969993
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines. PMID:25960936
Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations. PMID:25960144
PGMD: a comprehensive manually curated pharmacogenomic database. PMID:25939485
FOLFOX4 plus cetuximab treatment and RAS mutations in colorectal cancer. PMID:25937522
Next-Generation Sequencing of Stage IV Squamous Cell Lung Cancers Reveals an Association of PI3K Aberrations and Evidence of Clonal Heterogeneity in Patients with Brain Metastases. PMID:25929848
Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killing. PMID:25918225
Regulation of RAF protein kinases in ERK signalling. PMID:25907612
SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering. PMID:25903787
The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency. PMID:25903125
Multiple myeloma acquires resistance to EGFR inhibitor via induction of pentose phosphate pathway. PMID:25894462
The proteomic landscape of triple-negative breast cancer. PMID:25892236
CCI-779 (Temsirolimus) exhibits increased anti-tumor activity in low EGFR expressing HNSCC cell lines and is effective in cells with acquired resistance to cisplatin or cetuximab. PMID:25890004
Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment. PMID:25887790
ENCAPP: elastic-net-based prognosis prediction and biomarker discovery for human cancers. PMID:25887568
Detecting non-allelic homologous recombination from high-throughput sequencing data. PMID:25886137
Loregic: a method to characterize the cooperative logic of regulatory factors. PMID:25884877
Circulating tumor cells in hepatocellular carcinoma: a pilot study of detection, enumeration, and next-generation sequencing in cases and controls. PMID:25884197
Novel primary immunodeficiency candidate genes predicted by the human gene connectome. PMID:25883595
A classification system for clinical relevance of somatic variants identified in molecular profiling of cancer. PMID:25880439
A resource for cell line authentication, annotation and quality control. PMID:25877200
Semiconductor-based sequencing of formalin-fixed, paraffin-embedded colorectal cancer samples. PMID:25862747
Molecular biology of bladder cancer. PMID:25836928
Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme. PMID:25829971
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion. PMID:25829446
Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer. PMID:25824651
Characterizing the prevalence of chromosome instability in interval colorectal cancer. PMID:25810015
High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer. PMID:25808843
ROR1 as a novel therapeutic target for EGFR-mutant non-small-cell lung cancer patients with the EGFR T790M mutation. PMID:25806291
Hippo/YAP pathway for targeted therapy. PMID:25806284
Use of genome-wide association studies for cancer research and drug repositioning. PMID:25803826
ICan: an integrated co-alteration network to identify ovarian cancer-related genes. PMID:25803614
Protein domain-level landscape of cancer-type-specific somatic mutations. PMID:25794154
BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis. PMID:25794135
Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers. PMID:25768983
Structure-PPi: a module for the annotation of cancer-related single-nucleotide variants at protein-protein interfaces. PMID:25765346
Smoothened variants explain the majority of drug resistance in basal cell carcinoma. PMID:25759020
Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions. PMID:25755260
Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing. PMID:25751143
Identifying the determinants of response to MDM2 inhibition. PMID:25730903
Ploidy-Seq: inferring mutational chronology by sequencing polyploid tumor subpopulations. PMID:25729435
A somatic MAP3K3 mutation is associated with verrucous venous malformation. PMID:25728774
Molecular landscape of pancreatic cancer: implications for current clinical trials. PMID:25714017
Therapeutic opportunities within the DNA damage response. PMID:25709118
Biological and Clinical Implications of Clonal Heterogeneity and Clonal Evolution in Multiple Myeloma. PMID:25705146
Oncotator: cancer variant annotation tool. PMID:25703262
DNMT3A in haematological malignancies. PMID:25693834
DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes. PMID:25690659
Integrative multi-omics module network inference with Lemon-Tree. PMID:25679508
Mutation profile and clinical outcome of mixed endometrioid-serous endometrial carcinomas are different from that of pure endometrioid or serous carcinomas. PMID:25677978
La FAM fatale: USP9X in development and disease. PMID:25672900
Effect of mutation order on myeloproliferative neoplasms. PMID:25671252
Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors. PMID:25670082
p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. PMID:25659586
PON-P2: prediction method for fast and reliable identification of harmful variants. PMID:25647319
The next steps in next-gen sequencing of cancer genomes. PMID:25642706
PIK3CA mutations predict recurrence in localized microsatellite stable colon cancer. PMID:25641861
Autophagy Regulatory Network - a systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. PMID:25635527
MEN1 mutations in Hürthle cell (oncocytic) thyroid carcinoma. PMID:25625803
MDM4 expression as an indicator of TP53 reactivation by combined targeting of MDM2 and MDM4 in cancer cells without TP53 mutation. PMID:25621298
A pathway-centric survey of somatic mutations in Chinese patients with colorectal carcinomas. PMID:25617745
Brain tumor mutations detected in cerebral spinal fluid. PMID:25605683
Integrative genomics identifies YY1AP1 as an oncogenic driver in EpCAM(+) AFP(+) hepatocellular carcinoma. PMID:25597408
Open pipelines for integrated tumor genome profiles reveal differences between pancreatic cancer tumors and cell lines. PMID:25594743
Just like the rest of evolution in Mother Nature, the evolution of cancers may be driven by natural selection, and not by haphazard mutations. PMID:25594068
The neXtProt knowledgebase on human proteins: current status. PMID:25593349
Stepwise group sparse regression (SGSR): gene-set-based pharmacogenomic predictive models with stepwise selection of functional priors. PMID:25592566
Randomized Trial of Oral Cyclophosphamide and Veliparib in High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers, or BRCA-Mutant Ovarian Cancer. PMID:25589624
Genomic analysis of metastatic cutaneous squamous cell carcinoma. PMID:25589618
Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. PMID:25584894
Novel recurrently mutated genes in African American colon cancers. PMID:25583493
Sparse expression bases in cancer reveal tumor drivers. PMID:25583238
Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression. PMID:25582907
MADGiC: a model-based approach for identifying driver genes in cancer. PMID:25573922
Genome-wide discovery of human splicing branchpoints. PMID:25561518
Intrinsic subtypes, PIK3CA mutation, and the degree of benefit from adjuvant trastuzumab in the NSABP B-31 trial. PMID:25559813
Exome sequencing on malignant meningiomas identified mutations in neurofibromatosis type 2 (NF2) and meningioma 1 (MN1) genes. PMID:25549701
Whole genome sequencing as a means to assess pathogenic mutations in medical genetics and cancer. PMID:25548800
Clinically relevant genes and regulatory pathways associated with NRASQ61 mutations in melanoma through an integrative genomics approach. PMID:25537510
Implications of targeted genomic disruption of β-catenin in BxPC-3 pancreatic adenocarcinoma cells. PMID:25536063
Mitotic accumulation of dimethylated lysine 79 of histone H3 is important for maintaining genome integrity during mitosis in human cells. PMID:25533199
Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease. PMID:25528190
SG-ADVISER CNV: copy-number variant annotation and interpretation. PMID:25521334
ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma. PMID:25517749
Somatic mosaicism in the human genome. PMID:25513881
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations. PMID:25502805
Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma Multiforme. PMID:25502460
Role of Drosophila retinoblastoma protein instability element in cell growth and proliferation. PMID:25496208
Germline mutations in shelterin complex genes are associated with familial glioma. PMID:25482530
Oncogenic alterations in ERBB2/HER2 represent potential therapeutic targets across tumors from diverse anatomic sites of origin. PMID:25480824
Evolutionary and structural annotation of disease-associated mutations in human aminoacyl-tRNA synthetases. PMID:25476837
Preliminary whole-exome sequencing reveals mutations that imply common tumorigenicity pathways in multiple endocrine neoplasia type 1 patients. PMID:25456907
Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation. PMID:25437913
arrayMap 2014: an updated cancer genome resource. PMID:25428357
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. PMID:25426838
Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells. PMID:25426548
ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions. PMID:25425145
Integrated genomic characterization of papillary thyroid carcinoma. PMID:25417114
In silico prediction of splice-altering single nucleotide variants in the human genome. PMID:25416802
Kin-Driver: a database of driver mutations in protein kinases. PMID:25414382
Pathway connectivity and signaling coordination in the yeast stress-activated signaling network. PMID:25411400
Potential microRNA-mediated oncogenic intercellular communication revealed by pan-cancer analysis. PMID:25403569
CMPD: cancer mutant proteome database. PMID:25398898
Integrative genomic analyses of a novel cytokine, interleukin-34 and its potential role in cancer prediction. PMID:25395235
Evaluation of an integrated clinical workflow for targeted next-generation sequencing of low-quality tumor DNA using a 51-gene enrichment panel. PMID:25395014
Genomic landscape of metastatic colorectal cancer. PMID:25394515
Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations. PMID:25394176
Clonal architectures and driver mutations in metastatic melanomas. PMID:25393105
Predicting cancer prognosis using functional genomics data sets. PMID:25392695
The UCSC Cancer Genomics Browser: update 2015. PMID:25392408
Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types. PMID:25383969
MeT-DB: a database of transcriptome methylation in mammalian cells. PMID:25378335
Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines. PMID:25378332
Structure-based predictions broadly link transcription factor mutations to gene expression changes in cancers. PMID:25378323
Racial diversity of actionable mutations in non-small cell lung cancer. PMID:25376516
Human cancer databases (review). PMID:25369839
Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer. PMID:25368680
Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease. PMID:25363811
The mutational landscapes of genetic and chemical models of Kras-driven lung cancer. PMID:25363767
A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks. PMID:25362484
Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach. PMID:25360158
Onco-proteogenomics: cancer proteomics joins forces with genomics. PMID:25357240
The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data. PMID:25352556
Mutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy. PMID:25349966
Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations. PMID:25348012
Summarizing polygenic risks for complex diseases in a clinical whole-genome report. PMID:25341114
Regression analysis of combined gene expression regulation in acute myeloid leukemia. PMID:25340776
Germline mutations in MAP3K6 are associated with familial gastric cancer. PMID:25340522
Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and sequence variants associated with a genetic predisposition to prostate cancer. PMID:25335771
TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells. PMID:25333256
Integrated microRNA and mRNA transcriptome sequencing reveals the potential roles of miRNAs in stage I endometrioid endometrial carcinoma. PMID:25329664
The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease. PMID:25320178
Cdx1 and Cdx2 function as tumor suppressors. PMID:25320087
Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer. PMID:25315765
Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects. PMID:25309634
Analysis of the tryptic search space in UniProt databases. PMID:25307260
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. PMID:25301631
Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis. PMID:25294808
Mutation analysis of inhibitory guanine nucleotide binding protein alpha (GNAI) loci in young and familial pituitary adenomas. PMID:25291362
Review of current methods, applications, and data management for the bioinformatics analysis of whole exome sequencing. PMID:25288881
Functional annotation of putative regulatory elements at cancer susceptibility Loci. PMID:25288875
The structural basis for cancer treatment decisions. PMID:25277176
Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma. PMID:25274307
FunSeq2: a framework for prioritizing noncoding regulatory variants in cancer. PMID:25273974
High-Performance Integrated Virtual Environment (HIVE) Tools and Applications for Big Data Analysis. PMID:25271953
CancerPPD: a database of anticancer peptides and proteins. PMID:25270878
Hope for GWAS: relevant risk genes uncovered from GWAS statistical noise. PMID:25268625
Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors. PMID:25261369
Discrepancies in cancer genomic sequencing highlight opportunities for driver mutation discovery. PMID:25256751
Large differences in global transcriptional regulatory programs of normal and tumor colon cells. PMID:25253512
Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. PMID:25252692
Combining structural modeling with ensemble machine learning to accurately predict protein fold stability and binding affinity effects upon mutation. PMID:25243403
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. PMID:25240283
Mutation and Transcriptional Profiling of Formalin-Fixed Paraffin Embedded Specimens as Companion Methods to Immunohistochemistry for Determining Therapeutic Targets in Oropharyngeal Squamous Cell Carcinoma (OPSCC): A Pilot of Proof of Principle. PMID:25236499
Human germline and pan-cancer variomes and their distinct functional profiles. PMID:25232094
Personalized Oncology Suite: integrating next-generation sequencing data and whole-slide bioimages. PMID:25230706
Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation. PMID:25210032
Interleukin-4 receptor alpha overexpression in human bladder cancer correlates with the pathological grade and stage of the disease. PMID:25208941
Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. PMID:25202140
Modelling and simulation of mutant alleles of breast cancer metastasis suppressor 1 (BRMS1) gene. PMID:25187687
Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations. PMID:25182477
Quantitative analysis of mammalian translation initiation sites by FACS-seq. PMID:25170020
A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening. PMID:25165489
Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions. PMID:25164765
Cancer gene discovery goes mobile. PMID:25162801
ContrastRank: a new method for ranking putative cancer driver genes and classification of tumor samples. PMID:25161249
Morquio A syndrome-associated mutations: a review of alterations in the GALNS gene and a new locus-specific database. PMID:25137622
ACVR1 mutations in DIPG: lessons learned from FOP. PMID:25136070
Reporting tumor molecular heterogeneity in histopathological diagnosis. PMID:25127237
Functional kinomics identifies candidate therapeutic targets in head and neck cancer. PMID:25125259
HapMuC: somatic mutation calling using heterozygous germ line variants near candidate mutations. PMID:25123903
Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status. PMID:25123132
Mutation analysis of key genes in RAS/RAF and PI3K/PTEN pathways in Chinese patients with hepatocellular carcinoma. PMID:25120700
Identification of 33 candidate oncogenes by screening for base-specific mutations. PMID:25117815
Quantification of clonal circulating plasma cells in relapsed multiple myeloma. PMID:25113422
Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. PMID:25100735
Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer. PMID:25098926
The role of the Hippo pathway in human disease and tumorigenesis. PMID:25097728
Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer. PMID:25096367
Treatment of metastatic extramammary Paget's disease associated with adnexal adenocarcinoma, with anti-HER2 drugs based on genomic alteration ERBB2 S310F. PMID:25085898
KRAS mutation profile differences between rectosigmoid localized adenocarcinomas and colon adenocarcinomas. PMID:25083299
Clinicopathological significance of somatic RNF43 mutation and aberrant expression of ring finger protein 43 in intraductal papillary mucinous neoplasms of the pancreas. PMID:25081753
Human dominant disease genes are enriched in paralogs originating from whole genome duplication. PMID:25080083
Towards a HPC-oriented parallel implementation of a learning algorithm for bioinformatics applications. PMID:25077818
Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer? PMID:25057855
Genome-wide prediction of cancer driver genes based on SNP and cancer SNV data. PMID:25057442
The structural network of Interleukin-10 and its implications in inflammation and cancer. PMID:25056661
sapFinder: an R/Bioconductor package for detection of variant peptides in shotgun proteomics experiments. PMID:25053745
Next-generation sequencing identifies rare variants associated with Noonan syndrome. PMID:25049390
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. PMID:25043012
Loss of LKB1 in high-grade endometrial carcinoma: LKB1 is a novel transcriptional target of p53. PMID:25042259
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. PMID:25038752
Systematic identification and characterization of RNA editing in prostate tumors. PMID:25036877
Rho GTPases modulate malignant transformation of tumor cells. PMID:25036871
TERT promoter mutations and BRAF mutations are rare in sporadic, and TERT promoter mutations are absent in NF1-related malignant peripheral nerve sheath tumors. PMID:25035100
Outsmarting cancer: the power of hybrid genomic/proteomic biomarkers to predict drug response. PMID:25032256
Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma. PMID:25024164
Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs. PMID:25023699
A large-scale RNAi-based mouse tumorigenesis screen identifies new lung cancer tumor suppressors that repress FGFR signaling. PMID:25015643
HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. PMID:25011556
TORC2-a new player in genome stability. PMID:24992933
The domain landscape of virus-host interactomes. PMID:24991570
Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia. PMID:24986863
Integrated RNA and DNA sequencing improves mutation detection in low purity tumors. PMID:24970867
Mutational analysis of primary central nervous system lymphoma. PMID:24970810
Targeting TBK1 inhibits migration and resistance to MEK inhibitors in mutant NRAS melanoma. PMID:24962318
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. PMID:24957944
ALK-rearrangements and testing methods in non-small cell lung cancer: a review. PMID:24955213
HSF1 regulation of β-catenin in mammary cancer cells through control of HuR/elavL1 expression. PMID:24954509
Nicotine and oxidative stress induced exomic variations are concordant and overrepresented in cancer-associated genes. PMID:24947164
Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer. PMID:24943349
Evolution of histone 2A for chromatin compaction in eukaryotes. PMID:24939988
'Druggable' alterations detected by Ion Torrent in metastatic colorectal cancer patients. PMID:24932229
Detecting independent and recurrent copy number aberrations using interval graphs. PMID:24931984
Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. PMID:24931142
Expression level of hTERT is regulated by somatic mutation and common single nucleotide polymorphism at promoter region in glioblastoma. PMID:24930669
Small-molecule modulation of Ras signaling. PMID:24929527
Protein conservation and variation suggest mechanisms of cell type-specific modulation of signaling pathways. PMID:24922536
Role of PRMTs in cancer: Could minor isoforms be leaving a mark? PMID:24921003
Validation of the VE1 immunostain for the BRAF V600E mutation in melanoma. PMID:24917033
Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences. PMID:24909177
Deep sequencing of cancer-related genes revealed GNAS mutations to be associated with intraductal papillary mucinous neoplasms and its main pancreatic duct dilation. PMID:24897499
A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs. PMID:24894379
A RAS renaissance: emerging targeted therapies for KRAS-mutated non-small cell lung cancer. PMID:24893629
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. PMID:24889603
ATP-dependent chromatin remodeling complexes as novel targets for cancer therapy. PMID:24889532
Direct observation of genomic heterogeneity through local haplotyping analysis. PMID:24888354
Changing genetic paradigms: creating next-generation genetic databases as tools to understand the emerging complexities of genotype/phenotype relationships. PMID:24885908
Studying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactome. PMID:24881052
A web tool for the design and management of panels of genes for targeted enrichment and massive sequencing for clinical applications. PMID:24861626
Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions. PMID:24854082
An ex vivo assay of XRT-induced Rad51 foci formation predicts response to PARP-inhibition in ovarian cancer. PMID:24844596
Genetic interaction analysis of point mutations enables interrogation of gene function at a residue-level resolution: exploring the applications of high-resolution genetic interaction mapping of point mutations. PMID:24842270
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. PMID:24841718
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. PMID:24836576
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. PMID:24836286
Insights into the genetic structure and diversity of 38 South Asian Indians from deep whole-genome sequencing. PMID:24832686
Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice. PMID:24827933
Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy. PMID:24812339
Unique molecular signatures as a hallmark of patients with metastatic breast cancer: implications for current treatment paradigms. PMID:24811890
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. PMID:24807215
Using common variants to indicate cancer genes. PMID:24798945
Regulation and roles of bicarbonate transporters in cancer. PMID:24795638
Extraction of Molecular Features through Exome to Transcriptome Alignment. PMID:24791251
KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. PMID:24784001
Exploring the association of succinate dehydrogenase complex mutations with lymphoid malignancies. PMID:24781345
Diagnostic application of high resolution single nucleotide polymorphism array analysis for children with brain tumors. PMID:24767714
Genetic variations in colorectal cancer risk and clinical outcome. PMID:24764655
Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis. PMID:24760347
Principles and methods of integrative genomic analyses in cancer. PMID:24759209
Bioinformatics pipelines for targeted resequencing and whole-exome sequencing of human and mouse genomes: a virtual appliance approach for instant deployment. PMID:24752294
Pathways and therapeutic targets in melanoma. PMID:24743024
BAYSIC: a Bayesian method for combining sets of genome variants with improved specificity and sensitivity. PMID:24725768
What's that gene (or protein)? Online resources for exploring functions of genes, transcripts, and proteins. PMID:24723265
Tumor antigen discovery through translation of the cancer genome. PMID:24718952
Copper is required for oncogenic BRAF signalling and tumorigenesis. PMID:24717435
S-score: a scoring system for the identification and prioritization of predicted cancer genes. PMID:24710071
VCGDB: a dynamic genome database of the Chinese population. PMID:24708222
Diverse cells at the origin of lung adenocarcinoma. PMID:24707043
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma. PMID:24705252
Building and exploring an integrated human kinase network: global organization and medical entry points. PMID:24704859
Analysis of TP53 mutation status in human cancer cell lines: a reassessment. PMID:24700732
Deconvolving tumor purity and ploidy by integrating copy number alterations and loss of heterozygosity. PMID:24695406
POT1 loss-of-function variants predispose to familial melanoma. PMID:24686849
Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma. PMID:24686846
A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival. PMID:24681948
Structural pathways of cytokines may illuminate their roles in regulation of cancer development and immunotherapy. PMID:24670367
Novel insight into mutational landscape of head and neck squamous cell carcinoma. PMID:24667986
GeneSense: a new approach for human gene annotation integrated with protein-protein interaction networks. PMID:24667292
A framework for organizing cancer-related variations from existing databases, publications and NGS data using a High-performance Integrated Virtual Environment (HIVE). PMID:24667251
Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene. PMID:24658009
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. PMID:24656771
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. PMID:24631838
Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. PMID:24630729
Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma. PMID:24628946
Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib. PMID:24625776
Proceedings of the 12th Annual UT-ORNL-KBRIN Bioinformatics Summit 2013. PMID:24625056
Driver mutations of cancer epigenomes. PMID:24622842
Target enrichment using parallel nanoliter quantitative PCR amplification. PMID:24612714
Inferring probabilistic miRNA-mRNA interaction signatures in cancers: a role-switch approach. PMID:24609385
RNA binding protein-mediated post-transcriptional gene regulation in medulloblastoma. PMID:24608801
Concordance of genomic alterations between primary and recurrent breast cancer. PMID:24608573
NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes. PMID:24608173
Cancer evolution is associated with pervasive positive selection on globally expressed genes. PMID:24603726
Comparative genomic analysis of primary and synchronous metastatic colorectal cancers. PMID:24599305
STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious. PMID:24590058
Targeted therapy in gastric cancer: personalizing cancer treatment based on patient genome. PMID:24587678
Collection, integration and analysis of cancer genomic profiles: from data to insight. PMID:24584084
A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma. PMID:24584070
Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment. PMID:24571673
A genotoxic stress-responsive miRNA, miR-574-3p, delays cell growth by suppressing the enhancer of rudimentary homolog gene in vitro. PMID:24566139
Identification of gene fusions from human lung cancer mass spectrometry data. PMID:24564548
The structural pathway of interleukin 1 (IL-1) initiated signaling reveals mechanisms of oncogenic mutations and SNPs in inflammation and cancer. PMID:24550720
Navigating the multilayered organization of eukaryotic signaling: a new trend in data integration. PMID:24550716
Genetic lesions associated with chronic lymphocytic leukemia chemo-refractoriness. PMID:24550227
The GIST of targeted therapy for malignant melanoma. PMID:24531699
The polyphony of BACH2. PMID:24526774
Isocitrate dehydrogenase-1 mutations as prognostic biomarker in glioblastoma multiforme patients in West Bohemia. PMID:24511544
Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements. PMID:24505276
Abnormal gene expression and gene fusion in lung adenocarcinoma with high-throughput RNA sequencing. PMID:24503571
ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome. PMID:24501395
AMASS: a database for investigating protein structures. PMID:24497503
Integrated mRNA and microRNA transcriptome sequencing characterizes sequence variants and mRNA-microRNA regulatory network in nasopharyngeal carcinoma model systems. PMID:24490137
Functional annotation of noncoding sequence variants. PMID:24487584
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. PMID:24487277
Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma. PMID:24486590
Comprehensive molecular characterization of urothelial bladder carcinoma. PMID:24476821
SHEAR: sample heterogeneity estimation and assembly by reference. PMID:24476358
Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screens. PMID:24476156
C2orf62 and TTC17 are involved in actin organization and ciliogenesis in zebrafish and human. PMID:24475127
Genomic tools in acute myeloid leukemia: From the bench to the bedside. PMID:24474533
Integrative genetic characterization and phenotype correlations in pheochromocytoma and paraganglioma tumours. PMID:24466223
Somatic mutaome profile in human cancer tissues. PMID:24465236
Bionimbus: a cloud for managing, analyzing and sharing large genomics datasets. PMID:24464852
Deriving a mutation index of carcinogenicity using protein structure and protein interfaces. PMID:24454733
An evidence-based knowledgebase of pulmonary arterial hypertension to identify genes and pathways relevant to pathogenesis. PMID:24448676
Kinase fusions are frequent in Spitz tumours and spitzoid melanomas. PMID:24445538
Subclonal variant calling with multiple samples and prior knowledge. PMID:24443148
Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity. PMID:24442145
Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors. PMID:24440717
Environmental stress affects the activity of metabolic and growth factor signaling networks and induces autophagy markers in MCF7 breast cancer cells. PMID:24425749
Transcriptome-wide analysis of UTRs in non-small cell lung cancer reveals cancer-related genes with SNV-induced changes on RNA secondary structure and miRNA target sites. PMID:24416147
Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles. PMID:24415873
Quantitative prediction of the effect of genetic variation using hidden Markov models. PMID:24405700
Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer. PMID:24398047
Variants of the PPARD gene and their clinicopathological significance in colorectal cancer. PMID:24391853
Landscape of genomic alterations in cervical carcinomas. PMID:24390348
Genetics of rheumatoid arthritis contributes to biology and drug discovery. PMID:24390342
Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma. PMID:24367082
Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1. PMID:24366543
Successful whole-exome sequencing from a prostate cancer bone metastasis biopsy. PMID:24366412
Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma. PMID:24362935
Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets. PMID:24356096
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation. PMID:24351291
A quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype. PMID:24349113
Feature-based classification of amino acid substitutions outside conserved functional protein domains. PMID:24348198
Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours. PMID:24336498
SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. PMID:24335234
Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy. PMID:24335104
Evaluation of ultra-deep targeted sequencing for personalized breast cancer care. PMID:24326041
Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients. PMID:24324171
Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma. PMID:24317514
Ensembl 2014. PMID:24316576
Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia. PMID:24310736
Association of the autoimmune disease scleroderma with an immunologic response to cancer. PMID:24310608
Systematic genomic identification of colorectal cancer genes delineating advanced from early clinical stage and metastasis. PMID:24308539
PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas. PMID:24300787
Repurposing CRISPR/Cas9 for in situ functional assays. PMID:24298059
Cell line modeling for systems medicine in cancers (review). PMID:24297677
Systematic assessment of analytical methods for drug sensitivity prediction from cancer cell line data. PMID:24297534
NECTAR: a database of codon-centric missense variant annotations. PMID:24297257
PDBe: Protein Data Bank in Europe. PMID:24288376
Integrating structure to protein-protein interaction networks that drive metastasis to brain and lung in breast cancer. PMID:24278371
Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy. PMID:24265155
Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. PMID:24259466
Activities at the Universal Protein Resource (UniProt). PMID:24253303
Detectable clonal mosaicism in the human genome. PMID:24246702
An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing. PMID:24244370
RTK/ERK pathway under natural selection associated with prostate cancer. PMID:24223781
DriverDB: an exome sequencing database for cancer driver gene identification. PMID:24214964
Annotating cancer variants and anti-cancer therapeutics in reactome. PMID:24213504
ASXL1, TP53 and IKZF3 mutations are present in the chronic phase and blast crisis of chronic myeloid leukemia. PMID:24212482
Performance of common analysis methods for detecting low-frequency single nucleotide variants in targeted next-generation sequence data. PMID:24211364
CanDrA: cancer-specific driver missense mutation annotation with optimized features. PMID:24205039
Functional analysis of microRNA and transcription factor synergistic regulatory network based on identifying regulatory motifs in non-small cell lung cancer. PMID:24200043
Detection of low frequency FGFR3 mutations in the urine of bladder cancer patients using next-generation deep sequencing. PMID:24199178
Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells. PMID:24166297
The pancreatic expression database: recent extensions and updates. PMID:24163255
Inhibition of Rho-associated coiled-coil-forming kinase increases efficacy of measles virotherapy. PMID:24157925
Multiple cytoskeletal pathways and PI3K signaling mediate CDC-42-induced neuronal protrusion in C. elegans. PMID:24149939
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. PMID:24142049
Genes-environment interactions in obesity- and diabetes-associated pancreatic cancer: a GWAS data analysis. PMID:24136929
Identification of candidate genes for lung cancer somatic mutation test kits. PMID:24130455
Treatment-related toxicities in a phase II trial of dasatinib in patients with squamous cell carcinoma of the lung. PMID:24128713
Lessons from postgenome-wide association studies: functional analysis of cancer predisposition loci. PMID:24127939
Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain. PMID:24112705
Mutationally activated Rho GTPases in cancer. PMID:24088985
The Human Gene Mutation Database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine. PMID:24077912
The next-generation sequencing revolution and its impact on genomics. PMID:24074859
A simple consensus approach improves somatic mutation prediction accuracy. PMID:24073752
TOX3 mutations in breast cancer. PMID:24069272
Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterparts. PMID:24069199
Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines. PMID:24065145
The differential diagnosis of pilocytic astrocytoma with atypical features and malignant glioma: an analysis of 16 cases with emphasis on distinguishing molecular features. PMID:24057326
The landscape of somatic mutations in Down syndrome-related myeloid disorders. PMID:24056718
Epigenetic and genetic features of 24 colon cancer cell lines. PMID:24042735
Clinical and biological implications of driver mutations in myelodysplastic syndromes. PMID:24030381
The evolution of genome-scale models of cancer metabolism. PMID:24027532
Type-specific cell line models for type-specific ovarian cancer research. PMID:24023729
Systematic investigation of cancer-associated somatic point mutations in SNP databases. PMID:24022151
Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells. PMID:24002644
In vitro and in vivo models for analysis of resistance to anticancer molecular therapies. PMID:23992330
Discovering causal pathways linking genomic events to transcriptional states using Tied Diffusion Through Interacting Events (TieDIE). PMID:23986566
Navigating traditional chinese medicine network pharmacology and computational tools. PMID:23983798
Targeted next-generation sequencing panel (ThyroSeq) for detection of mutations in thyroid cancer. PMID:23979959
RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53. PMID:23973461
PharmGKB summary: very important pharmacogene information for the epidermal growth factor receptor. PMID:23962910
Towards precision medicine: advances in computational approaches for the analysis of human variants. PMID:23962656
NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition. PMID:23958853
BlackOPs: increasing confidence in variant detection through mappability filtering. PMID:23935067
Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. PMID:23911959
Computational approaches to identify functional genetic variants in cancer genomes. PMID:23900255
Ras-mutant cancer cells display B-Raf binding to Ras that activates extracellular signal-regulated kinase and is inhibited by protein kinase A phosphorylation. PMID:23893412
Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia. PMID:23891977
The pathogenesis of atypical proliferative Brenner tumor: an immunohistochemical and molecular genetic analysis. PMID:23887305
Discovery of structural alterations in solid tumor oligodendroglioma by single molecule analysis. PMID:23885787
Endometrial tumour BRAF mutations and MLH1 promoter methylation as predictors of germline mismatch repair gene mutation status: a literature review. PMID:23880961
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Receptor tyrosine kinases with intracellular pseudokinase domains. PMID:23863174
Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. PMID:23833300
Targeted re-sequencing analysis of 25 genes commonly mutated in myeloid disorders in del(5q) myelodysplastic syndromes. PMID:23831921
Assessment of computational methods for predicting the effects of missense mutations in human cancers. PMID:23819521
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. PMID:23817572
Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms. PMID:23817176
From human genome to cancer genome: the first decade. PMID:23817046
Dissecting disease inheritance modes in a three-dimensional protein network challenges the "guilt-by-association" principle. PMID:23791107
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. PMID:23788652
Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells. PMID:23775793
Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles. PMID:23765252
Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. PMID:23760024
A comparison of 100 human genes using an alu element-based instability model. PMID:23755193
Effect of single amino acid substitution observed in cancer on Pim-1 kinase thermodynamic stability and structure. PMID:23755147
Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinase. PMID:23754386
The UCSC Interaction Browser: multidimensional data views in pathway context. PMID:23748957
Comparison of modules of wild type and mutant Huntingtin and TP53 protein interaction networks: implications in biological processes and functions. PMID:23741403
A recurrent PDGFRB mutation causes familial infantile myofibromatosis. PMID:23731537
Identification of driver genes in hepatocellular carcinoma by exome sequencing. PMID:23728943
Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap). PMID:23723294
Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors. PMID:23718828
Germline and somatic mutations in cyclin-dependent kinase inhibitor genes CDKN1A, CDKN2B, and CDKN2C in sporadic parathyroid adenomas. PMID:23715670
H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation. PMID:23707062
Lack of SF3B1 R625 mutations in cutaneous melanoma. PMID:23694694
The identification of gut neuroendocrine tumor disease by multiple synchronous transcript analysis in blood. PMID:23691035
The mutational landscape of adenoid cystic carcinoma. PMID:23685749
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. PMID:23685747
Genetic characterization of SF3B1 mutations in single chronic lymphocytic leukemia cells. PMID:23685408
Equivalent indels--ambiguous functional classes and redundancy in databases. PMID:23658777
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. PMID:23640210
Chapter 15: disease gene prioritization. PMID:23633938
Implementing personalized cancer genomics in clinical trials. PMID:23629504
Annotation of genes having candidate somatic mutations in acute myeloid leukemia with whole-exome sequencing using concept lattice analysis. PMID:23613681
Desktop transcriptome sequencing from archival tissue to identify clinically relevant translocations. PMID:23598961
Clinical analysis and interpretation of cancer genome data. PMID:23589549
Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα. PMID:23589289
Systematic identification of combinatorial drivers and targets in cancer cell lines. PMID:23577104
Multiple receptor tyrosine kinases promote the in vitro phenotype of metastatic human osteosarcoma cell lines. PMID:23552467
Cancer genome landscapes. PMID:23539594
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. PMID:23535730
Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. PMID:23535648
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. PMID:23525077
TIARA genome database: update 2013. PMID:23515433
Dual coordination of post translational modifications in human protein networks. PMID:23505349
POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. PMID:23502782
Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K-mutated melanoma. PMID:23444215
siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors. PMID:23435420
Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer. PMID:23426136
Cancer driver-passenger distinction via sporadic human and dog cancer comparison: a proof-of-principle study with colorectal cancer. PMID:23416983
Next generation sequencing in cancer research and clinical application. PMID:23406336
Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies. PMID:23401433
Bevacizumab-based treatment in colorectal cancer with a NRAS Q61K mutation. PMID:23400451
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. PMID:23396013
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review. PMID:23384594
DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer. PMID:23383675
Identification of ovarian cancer associated genes using an integrated approach in a Boolean framework. PMID:23383610
Single molecule molecular inversion probes for targeted, high-accuracy detection of low-frequency variation. PMID:23382536
Supervillin-mediated suppression of p53 protein enhances cell survival. PMID:23382381
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia. PMID:23377183
KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. PMID:23373539
Genome-wide assessment of the association of rare and common copy number variations to testicular germ cell cancer. PMID:23372565
Molecular markers as therapeutic targets in lung cancer. PMID:23369726
HeurAA: accurate and fast detection of genetic variations with a novel heuristic amplicon aligner program for next generation sequencing. PMID:23349847
The genetic landscape of high-risk neuroblastoma. PMID:23334666
A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. PMID:23324396
GSVA: gene set variation analysis for microarray and RNA-seq data. PMID:23323831
STOP gene Phactr4 is a tumor suppressor. PMID:23319639
Embryonic stem cells or induced pluripotent stem cells? A DNA integrity perspective. PMID:23317057
Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers. PMID:23303603
HitWalker: variant prioritization for personalized functional cancer genomics. PMID:23303510
Multi-analyte network markers for tumor prognosis. PMID:23300836
Mutation scanning using MUT-MAP, a high-throughput, microfluidic chip-based, multi-analyte panel. PMID:23284662
An integrative analysis of cellular contexts, miRNAs and mRNAs reveals network clusters associated with antiestrogen-resistant breast cancer cells. PMID:23270413
CellLineMiner: a knowledge portal for human cell lines. PMID:23251048
In silico prediction of tumor antigens derived from functional missense mutations of the cancer gene census. PMID:23243591
Protein arginine methyltransferases and cancer. PMID:23235912
Ensembl 2013. PMID:23203987
The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013. PMID:23203882
STRING v9.1: protein-protein interaction networks, with increased coverage and integration. PMID:23203871
DbVar and DGVa: public archives for genomic structural variation. PMID:23193291
Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines. PMID:23188824
SomamiR: a database for somatic mutations impacting microRNA function in cancer. PMID:23180788
Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. PMID:23180760
Elucidating distinct roles for NF1 in melanomagenesis. PMID:23171796
Building a statistical model for predicting cancer genes. PMID:23166609
Genenames.org: the HGNC resources in 2013. PMID:23161694
Atlas of genetics and cytogenetics in oncology and haematology in 2013. PMID:23161685
Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. PMID:23161513
Preliminary evidence of different selection pressures on cancer cells as compared to normal tissues. PMID:23146329
Genome instability caused by a germline mutation in the human DNA repair gene POLB. PMID:23144636
ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data. PMID:23143107
Genetic pathways in disorders of epidermal differentiation. PMID:23141808
A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis. PMID:23133403
Recurrent targets of aberrant somatic hypermutation in lymphoma. PMID:23131835
An integrated map of genetic variation from 1,092 human genomes. PMID:23128226
CaGe: A Web-Based Cancer Gene Annotation System for Cancer Genomics. PMID:23105926
Integrative analysis of somatic mutations altering microRNA targeting in cancer genomes. PMID:23091610
Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in antiapoptotic and chromatin-remodeling genes. PMID:23091298
Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases. PMID:23076159
Gene Fusion Markup Language: a prototype for exchanging gene fusion data. PMID:23072312
TSGene: a web resource for tumor suppressor genes. PMID:23066107
Genetically engineered mouse models and human osteosarcoma. PMID:23036272
Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns. PMID:23034185
Bioinformatics for cancer immunology and immunotherapy. PMID:22986455
Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity. PMID:22981675
Genomic Determinants of PI3K Pathway Inhibitor Response in Cancer. PMID:22970424
Distinct and competitive regulatory patterns of tumor suppressor genes and oncogenes in ovarian cancer. PMID:22952919
A computational framework for boosting confidence in high-throughput protein-protein interaction datasets. PMID:22937800
Novel somatic mutations to PI3K pathway genes in metastatic melanoma. PMID:22912864
Regulating the response to targeted MEK inhibition in melanoma: enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation. PMID:22895053
The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development. PMID:22891273
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. PMID:22885699
Uncovering MicroRNA and Transcription Factor Mediated Regulatory Networks in Glioblastoma. PMID:22829753
K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc. PMID:22826122
The rebel angel: mutant p53 as the driving oncogene in breast cancer. PMID:22822097
A landscape of driver mutations in melanoma. PMID:22817889
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. PMID:22810586
Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasion. PMID:22807579
BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors. PMID:22798288
The genetics and biology of KRAS in lung cancer. PMID:22776234
Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec. PMID:22761113
Predicting cancer-associated germline variations in proteins. PMID:22759656
Applying next-generation sequencing to pancreatic cancer treatment. PMID:22751458
Leukemia gene atlas--a public platform for integrative exploration of genome-wide molecular data. PMID:22720055
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. PMID:22698401
CellBase, a comprehensive collection of RESTful web services for retrieving relevant biological information from heterogeneous sources. PMID:22693220
Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis. PMID:22689059
Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus. PMID:22665440
Use of mutation profiles to refine the classification of endometrial carcinomas. PMID:22653804
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. PMID:22634755
arrayMap: a reference resource for genomic copy number imbalances in human malignancies. PMID:22629346
Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors. PMID:22628563
Recurrent hemizygous deletions in cancers may optimize proliferative potential. PMID:22628553
LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. PMID:22615920
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. PMID:22610119
A comprehensive survey of Ras mutations in cancer. PMID:22589270
High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. PMID:22585170
Molecular ontogeny of donor-derived follicular lymphomas occurring after hematopoietic cell transplantation. PMID:22585168
Genetic variants in the PI3K/PTEN/AKT/mTOR pathway predict head and neck cancer patient second primary tumor/recurrence risk and response to retinoid chemoprevention. PMID:22577058
Chronic inflammation in cancer development. PMID:22566887
Detectable clonal mosaicism and its relationship to aging and cancer. PMID:22561519
SNPnexus: a web server for functional annotation of novel and publicly known genetic variants (2012 update). PMID:22544707
Functional and topological properties in hepatocellular carcinoma transcriptome. PMID:22539975
Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides. PMID:22529291
Molecular prescreening to select patient population in early clinical trials. PMID:22473105
Structural stability of human protein tyrosine phosphatase ρ catalytic domain: effect of point mutations. PMID:22389709
Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas. PMID:22355676
Oncogene Mutation Survey in MPNST Cell Lines Enhances the Dominant Role of Hyperactive Ras in NF1 Associated Pro-Survival and Malignancy. PMID:22346343
Evolution of the cancer genome. PMID:22342180
Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. PMID:22341455
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. PMID:22327622
JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data. PMID:22285562
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. PMID:22265402
The diverse and complex roles of NF-κB subunits in cancer. PMID:22257950
Role of Bcl-3 in solid tumors. PMID:22195643
Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice. PMID:22194995
The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer. PMID:22194470
The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma. PMID:22183185
SomaticSniper: identification of somatic point mutations in whole genome sequencing data. PMID:22155872
The 2012 Nucleic Acids Research Database Issue and the online Molecular Biology Database Collection. PMID:22144685
MetaBase--the wiki-database of biological databases. PMID:22139927
Personalized oncology through integrative high-throughput sequencing: a pilot study. PMID:22133722
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. PMID:22037554
Critical amino acid residues in proteins: a BioMart integration of Reactome protein annotations with PRIDE mass spectrometry data and COSMIC somatic mutations. PMID:22025670
Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants. PMID:22016070
canSAR: an integrated cancer public translational research and drug discovery resource. PMID:22013161
The Reactome BioMart. PMID:22012987
Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production. PMID:21996744
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. PMID:21984976
Copy number and loss of heterozygosity detected by SNP array of formalin-fixed tissues using whole-genome amplification. PMID:21966361
Germline BAP1 mutations and tumor susceptibility. PMID:21956388
Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors. PMID:21931803
Ras trafficking, localization and compartmentalized signalling. PMID:21924373
Accessing protein conformational ensembles using room-temperature X-ray crystallography. PMID:21918110
p53-independent epigenetic repression of the p21(WAF1) gene in T-cell acute lymphoblastic leukemia. PMID:21903579
Annotating individual human genomes. PMID:21839162
PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers. PMID:21829508
The mutational landscape of head and neck squamous cell carcinoma. PMID:21798893
Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer. PMID:21795997
A mosaic activating mutation in AKT1 associated with the Proteus syndrome. PMID:21793738
Ras in cancer and developmental diseases. PMID:21779504
Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations. PMID:21764165
A new disease-specific machine learning approach for the prediction of cancer-causing missense variants. PMID:21763417
Absence of common activating mutations of the epidermal growth factor receptor gene in thyroid cancers from American and Japanese patients. PMID:21717456
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. PMID:21670202
Using BioMart as a framework to manage and query pancreatic cancer data. PMID:21666272
p21-activated kinase 1: PAK'ed with potential. PMID:21653999
Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma. PMID:21575252
Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, Condel. PMID:21457909
Making sense of cancer genomic data. PMID:21406553
The 2011 Nucleic Acids Research Database Issue and the online Molecular Biology Database Collection. PMID:21177655
COSMIC: the Catalogue Of Somatic Mutations In Cancer PubMed citations: 1200.

1200 articles citing: COSMIC: the Catalogue Of Somatic Mutations In Cancer

Accurate determination of CRISPR-mediated gene fitness in transplantable tumours. PMID:35927228
PO2RDF: representation of real-world data for precision oncology using resource description framework. PMID:35907849
Weighted Correlation Network Analysis of Cancer Stem Cell-Related Prognostic Biomarkers in Esophageal Squamous Cell Carcinoma. PMID:35899307
New Drug Development and Clinical Trial Design by Applying Genomic Information Management. PMID:35893795
SMARCB1-Deficient Cancers: Novel Molecular Insights and Therapeutic Vulnerabilities. PMID:35892904
Molecular Profiles of Serum-Derived Extracellular Vesicles in High-Grade Serous Ovarian Cancer. PMID:35892848
Characteristics and Treatment Outcomes in Advanced-Stage Non-Small Cell Lung Cancer Patients with a KRAS G12C Mutation: A Real-World Study. PMID:35887862
TAaCGH Suite for Detecting Cancer-Specific Copy Number Changes Using Topological Signatures. PMID:35885119
P63 and P73 Activation in Cancers with p53 Mutation. PMID:35884795
Mutational Signature and Integrative Genomic Analysis of Human Papillomavirus-Associated Penile Squamous Cell Carcinomas from Latin American Patients. PMID:35884575
Ras-Related Protein Rab-32 and Thrombospondin 1 Confer Resistance to the EGFR Tyrosine Kinase Inhibitor Osimertinib by Activating Focal Adhesion Kinase in Non-Small Cell Lung Cancer. PMID:35884490
Targeted Next-Generation Sequencing of Thymic Epithelial Tumours Revealed Pathogenic Variants in KIT, ERBB2, KRAS, and TP53 in 30% of Thymic Carcinomas. PMID:35884448
DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancers. PMID:35883104
Pan-cancer analyses of synonymous mutations based on tissue-specific codon optimality. PMID:35860410
Aristolochic acid-associated cancers: a public health risk in need of global action. PMID:35854147
RNA-SSNV: A Reliable Somatic Single Nucleotide Variant Identification Framework for Bulk RNA-Seq Data. PMID:35846154
Exploring the Conformational Impact of Glycine Receptor TM1-2 Mutations Through Coarse-Grained Analysis and Atomistic Simulations. PMID:35836931
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis. PMID:35835912
ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1. PMID:35831023
Computational estimation of quality and clinical relevance of cancer cell lines. PMID:35822563
Immune and Genetic Signatures of Breast Carcinomas Triggering Anti-Yo-Associated Paraneoplastic Cerebellar Degeneration. PMID:35821104
Targeted sequencing of candidate gene regions for myelofibrosis in dogs. PMID:35815881
Duplication of 8q24 in Chronic Lymphocytic Leukemia: Cytogenetic and Molecular Biologic Analysis of MYC Aberrations. PMID:35814434
Challenges and Obstacles in Applying Therapeutical Indications Formulated in Molecular Tumor Boards. PMID:35804968
J-SPACE: a Julia package for the simulation of spatial models of cancer evolution and of sequencing experiments. PMID:35804300
Genetic association and single-cell transcriptome analyses reveal distinct features connecting autoimmunity with cancers. PMID:35800769
A paediatric dysembryoplastic neuroepithelial tumour (DNET) with deregulated stem cell markers: a case report. PMID:35800288
Detection of temozolomide-induced hypermutation and response to PD-1 checkpoint inhibitor in recurrent glioblastoma. PMID:35795471
Cross Analysis of Genomic-Pathologic Features on Multiple Primary Hepatocellular Carcinoma. PMID:35795211
Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. PMID:35794096
Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects. PMID:35788175
KDM6A missense variants hamper H3 histone demethylation in lung squamous cell carcinoma. PMID:35782738
Mutational landscape of pan-cancer patients with PIK3CA alterations in Chinese population. PMID:35778737
A combinatorial system to examine the enzymatic repair of multiply damaged DNA substrates. PMID:35776119
Structural basis for SHOC2 modulation of RAS signalling. PMID:35768504
The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma. PMID:35768438
WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage. PMID:35768435
The impact of rare germline variants on human somatic mutation processes. PMID:35764656
Identification of Prognostic and Tumor Microenvironment by Shelterin Complex-Related Signatures in Oral Squamous Cell Carcinoma. PMID:35757510
A new deep learning technique reveals the exclusive functional contributions of individual cancer mutations. PMID:35753349
Genomic and transcriptomic analysis of Korean colorectal cancer patients. PMID:35751785
Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies. PMID:35750695
Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations. PMID:35741042
HypoxaMIRs: Key Regulators of Hallmarks of Colorectal Cancer. PMID:35741024
A Novel Proteogenomic Integration Strategy Expands the Breadth of Neo-Epitope Sources. PMID:35740681
APOBEC Alteration Contributes to Tumor Growth and Immune Escape in Pan-Cancer. PMID:35740493
A phylogenetic approach to study the evolution of somatic mutational processes in cancer. PMID:35732905
Integrating chromatin accessibility states in the design of targeted sequencing panels for liquid biopsy. PMID:35729208
Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2. PMID:35727845
Genome-wide mapping of somatic mutation rates uncovers drivers of cancer. PMID:35726091
The genomic landscape of canine diffuse large B-cell lymphoma identifies distinct subtypes with clinical and therapeutic implications. PMID:35726023
The DNA methylation landscape of five pediatric-tumor types. PMID:35707123
Signatures of copy number alterations in human cancer. PMID:35705804
Network approaches for modeling the effect of drugs and diseases. PMID:35704883
The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma. PMID:35703534
FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity. PMID:35703180
DisPhaseDB: An integrative database of diseases related variations in liquid-liquid phase separation proteins. PMID:35685370
Early Development of Ubiquitous Acanthocytosis and Extravascular Hemolysis in Lung Cancer Patients Receiving Alectinib. PMID:35681698
Molecular Oncology of Bladder Cancer from Inception to Modern Perspective. PMID:35681556
APOBEC-mediated mutagenesis is a favorable predictor of prognosis and immunotherapy for bladder cancer patients: evidence from pan-cancer analysis and multiple databases. PMID:35673559
ENDORSE: a prognostic model for endocrine therapy in estrogen-receptor-positive breast cancers. PMID:35671075
Low-grade tracheal adenocarcinoma with ETV6::NTRK3 fusion: unique morphology akin to subsets of sinonasal low-grade non-intestinal-type adenocarcinoma. PMID:35670854
Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Squamous Cell Carcinomas Identifies KMT2C as a Potential Tumor Suppressor. PMID:35664801
MCM10 is a Prognostic Biomarker and Correlated With Immune Checkpoints in Ovarian Cancer. PMID:35664337
Combined exome and transcriptome sequencing of non-muscle-invasive bladder cancer: associations between genomic changes, expression subtypes, and clinical outcomes. PMID:35655252
AnthraxKP: a knowledge graph-based, Anthrax Knowledge Portal mined from biomedical literature. PMID:35653350
Breaking the Immune Complexity of the Tumor Microenvironment Using Single-Cell Technologies. PMID:35651929
Comprehensive Genomic Characterization of Tumor Microenvironment and Relevant Signature in Clear Cell Renal Cell Carcinoma. PMID:35651807
Annotation Query (AnnoQ): an integrated and interactive platform for large-scale genetic variant annotation. PMID:35640593
Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma. PMID:35637530
Identifying tumor cells at the single-cell level using machine learning. PMID:35637521
Identification of lung cancer drivers by comparison of the observed and the expected numbers of missense and nonsense mutations in individual human genes. PMID:35634240
Cutaneous malignant melanoma incidence is strongly associated with European depigmented skin type regardless of ambient ultraviolet radiation levels: evidence from Worldwide population-based data. PMID:35634021
Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas. PMID:35630580
Correlation of Immunological and Molecular Profiles with Response to Crizotinib in Alveolar Soft Part Sarcoma: An Exploratory Study Related to the EORTC 90101 "CREATE" Trial. PMID:35628499
Inferring Potential Cancer Driving Synonymous Variants. PMID:35627162
Homologous Recombination Repair in Biliary Tract Cancers: A Prime Target for PARP Inhibition? PMID:35626165
Making Invisible RNA Visible: Discriminative Sequencing Methods for RNA Molecules with Specific Terminal Formations. PMID:35625540
Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers. PMID:35615018
Genomic Evolution and Personalized Therapy of an Infantile Fibrosarcoma Harboring an NTRK Oncogenic Fusion. PMID:35613412
Convergent Alterations of a Protein Hub Produce Divergent Effects within a Binding Site. PMID:35613319
iUMRG: multi-layered network-guided propagation modeling for the inference of susceptibility genes and potential drugs against uveal melanoma. PMID:35610253
Multiaspect Examinations of Possible Alternative Mappings of Identified Variant Peptides: A Case Study on the HEK293 Cell Line. PMID:35601313
High DKK3 expression related to immunosuppression was associated with poor prognosis in glioblastoma: machine learning approach. PMID:35599254
Genomic features of Chinese small cell lung cancer. PMID:35596192
Automated next-generation profiling of genomic alterations in human cancers. PMID:35595835
Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene. PMID:35587635
Tumor and Constitutional Sequencing for Neurofibromatosis Type 1. PMID:35584348
All EGFR mutations are (not) created equal: focus on uncommon EGFR mutations. PMID:35581383
Cancer driver drug interaction explorer. PMID:35580047
Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck. PMID:35572996
Dynamic Interplay between Structural Variations and 3D Genome Organization in Pancreatic Cancer. PMID:35570408
The molecular characteristics of gastric cancer patients living in Qinghai-Tibetan Plateau. PMID:35568828
Comprehensive Analysis of the Structure and Function of Peptide:N-Glycanase 1 and Relationship with Congenital Disorder of Deglycosylation. PMID:35565658
Unmasking the suppressed immunopeptidome of EZH2-mutated diffuse large B-cell lymphomas through combination drug treatment. PMID:35561310
Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer. PMID:35559669
TMC-SNPdb 2.0: an ethnic-specific database of Indian germline variants. PMID:35551364
Genetic and chemotherapeutic influences on germline hypermutation. PMID:35545669
Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment naïve gBRCA+ breast cancers. PMID:35538088
Clinicopathologic and genomic characteristics of mucinous gastric adenocarcinoma. PMID:35534656
The Role of CTNNB1 in Endometrial Cancer. PMID:35531470
Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops. PMID:35524550
Chemical Proteomics of the Tumor Suppressor Fhit Covalently Bound to the Cofactor Ap3A Elucidates Its Inhibitory Action on Translation. PMID:35522782
Noncoding RNAs endogenously rule the cancerous regulatory realm while proteins govern the normal. PMID:35521545
Germline predisposition to pediatric Ewing sarcoma is characterized by inherited pathogenic variants in DNA damage repair genes. PMID:35512711
Identification of a Gene Signature to Aid Treatment Decisions by Integrated Analysis of Mutated Genes Between Primary and Metastatic Prostate Cancer. PMID:35495154
Genome interpretation using in silico predictors of variant impact. PMID:35488922
A Validation Framework for Somatic Copy Number Detection in Targeted Sequencing Panels. PMID:35487348
Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy. PMID:35486732
Analytical and clinical validation of an amplicon-based next generation sequencing assay for ultrasensitive detection of circulating tumor DNA. PMID:35486650
At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy. PMID:35484287
Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA. PMID:35484264
DNA-based copy number analysis confirms genomic evolution of PDX models. PMID:35484194
Non-canonical genomic driver mutations of urethane carcinogenesis. PMID:35482806
Pharmacogenomic Cluster Analysis of Lung Cancer Cell Lines Provides Insights into Preclinical Model Selection in NSCLC. PMID:35476185
A pan-cancer survey of cell line tumor similarity by feature-weighted molecular profiles. PMID:35475239
Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study. PMID:35471999
Machine learning assisted analysis of breast cancer gene expression profiles reveals novel potential prognostic biomarkers for triple-negative breast cancer. PMID:35465161
Models of Renal Cell Carcinoma Used to Investigate Molecular Mechanisms and Develop New Therapeutics. PMID:35463327
Germline MBD4 deficiency causes a multi-tumor predisposition syndrome. PMID:35460607
Clinical and Molecular Basis of Hepatocellular Carcinoma after Hepatitis C Virus Eradication. PMID:35456105
Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gastrointestinal Tract: A Case Series. PMID:35455885
Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing. PMID:35452513
The NHS England 100,000 Genomes Project: feasibility and utility of centralised genome sequencing for children with cancer. PMID:35449451
Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity. PMID:35449156
H3K4 demethylase KDM5B regulates cancer cell identity and epigenetic plasticity. PMID:35440714
A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese population. PMID:35440542
Clinical Utility and Performance of an Ultrarapid Multiplex RNA-Based Assay for Detection of ALK, ROS1, RET, and NTRK1/2/3 Rearrangements and MET Exon 14 Skipping Alterations. PMID:35430374
Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon. PMID:35425963
BAP1-Related ceRNA (NEAT1/miR-10a-5p/SERPINE1) Promotes Proliferation and Migration of Kidney Cancer Cells. PMID:35425712
Q61 mutant-mediated dynamics changes of the GTP-KRAS complex probed by Gaussian accelerated molecular dynamics and free energy landscapes. PMID:35425180
The E3 ubiquitin ligase SMURF2 stabilizes RNA editase ADAR1p110 and promotes its adenosine-to-inosine (A-to-I) editing function. PMID:35403872
Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia. PMID:35401501
Integrated genomic analyses identify high-risk factors and actionable targets in T-cell acute lymphoblastic leukemia. PMID:35399540
Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas. PMID:35396535
Diagnostic value of thyroid imaging reporting and data system combined with BRAFV600E mutation analysis in Bethesda categories III-V thyroid nodules. PMID:35395862
Deciphering the Increased Prevalence of TP53 Mutations in Metastatic Prostate Cancer. PMID:35392296
Exome and Tissue-Associated Microbiota as Predictive Markers of Response to Neoadjuvant Treatment in Locally Advanced Rectal Cancer. PMID:35392220
Multivalent DNA and nucleosome acidic patch interactions specify VRK1 mitotic localization and activity. PMID:35390161
Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA. PMID:35385349
High cyclin E1 protein, but not gene amplification, is prognostic for basal-like breast cancer. PMID:35384378
The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein. PMID:35383292
The contribution of evolutionarily volatile promoters to molecular phenotypes and human trait variation. PMID:35379293
SUITOR: Selecting the number of mutational signatures through cross-validation. PMID:35377867
Establishment and Characterization of Brain Cancer Primary Cell Cultures From Patients to Enable Phenotypic Screening for New Drugs. PMID:35370679
Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability. PMID:35367648
Standardized evidence-based approach for assessment of oncogenic and clinical significance of NTRK fusions. PMID:35366592
Exploring Methods of Targeting Histone Methyltransferases and Their Applications in Cancer Therapeutics. PMID:35363464
TBGA: a large-scale Gene-Disease Association dataset for Biomedical Relation Extraction. PMID:35361129
Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma. PMID:35354817
Distinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification. PMID:35347147
Findings from precision oncology in the clinic: rare, novel variants are a significant contributor to scaling molecular diagnostics. PMID:35346197
Aberrant SKP1 Expression: Diverse Mechanisms Impacting Genome and Chromosome Stability. PMID:35345853
Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers. PMID:35338148
Re-evaluation of missense variant classifications in NF2. PMID:35332608
Pan-cancer analysis identifies BIRC5 as a prognostic biomarker. PMID:35331169
The Prognostic Relevance of PMCA4 Expression in Melanoma: Gender Specificity and Implications for Immune Checkpoint Inhibition. PMID:35328746
An In Vivo Inflammatory Loop Potentiates KRAS Blockade. PMID:35327394
Circulating Tumor DNA Profiling of a Diffuse Large B Cell Lymphoma Patient with Secondary Acute Myeloid Leukemia. PMID:35326522
MEN4, the MEN1 Mimicker: A Case Series of three Phenotypically Heterogenous Patients With Unique CDKN1B Mutations. PMID:35323929
Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders. PMID:35322263
APOBEC Mutational Signature and Tumor Mutational Burden as Predictors of Clinical Outcomes and Treatment Response in Patients With Advanced Urothelial Cancer. PMID:35321431
Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers. PMID:35320711
A clinician's handbook for using ctDNA throughout the patient journey. PMID:35307037
Interactions of circRNAs with methylation: An important aspect of circRNA biogenesis and function (Review). PMID:35302170
Prion-like domains drive CIZ1 assembly formation at the inactive X chromosome. PMID:35289833
RIOK1 is associated with non-small cell lung cancer clinical characters and contributes to cancer progression. PMID:35281872
Frequency and Clinicopathological Characteristics of Patients With KRAS/BRAF Double-Mutant Colorectal Cancer: An In Silico Study. PMID:35280113
In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2. PMID:35273342
A saturation-mutagenesis analysis of the interplay between stability and activation in Ras. PMID:35272765
FlyBase: a guided tour of highlighted features. PMID:35266522
The seventh international RASopathies symposium: Pathways to a cure-expanding knowledge, enhancing research, and therapeutic discovery. PMID:35266292
Computing microRNA-gene interaction networks in pan-cancer using miRDriver. PMID:35260634
Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells. PMID:35252869
Landscape of TP53 Alterations in Chronic Lymphocytic Leukemia via Data Mining Mutation Databases. PMID:35251978
Sequencing of BRCA1/2-alterations using NGS-based technology: annotation as a challenge. PMID:35251494
PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features. PMID:35247012
The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia. PMID:35243242
Prevalence of (Epi)genetic Predisposing Factors in a 5-Year Unselected National Wilms Tumor Cohort: A Comprehensive Clinical and Genomic Characterization. PMID:35230882
Computational Resources for the Interpretation of Variations in Cancer. PMID:35230689
The Architecture of a Precision Oncology Platform. PMID:35230680
DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors. PMID:35227293
Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding? PMID:35226061
Cross-continental admixture in the Kho population from northwest Pakistan. PMID:35217804
A Low-Activity Polymorphic Variant of Human NEIL2 DNA Glycosylase. PMID:35216329
Predicting Anticancer Drug Resistance Mediated by Mutations. PMID:35215249
Analyses of human cancer driver genes uncovers evolutionarily conserved RNA structural elements involved in posttranscriptional control. PMID:35213597
Discovery of an unusually high number of de novo mutations in sperm of older men using duplex sequencing. PMID:35210354
Metabolomics and the Multi-Omics View of Cancer. PMID:35208228
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei. PMID:35207746
Low Mutational Burden of Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue in Patients with Primary Sjogren's Syndrome. PMID:35205758
Detection of Cancer Mutations by Urine Liquid Biopsy as a Potential Tool in the Clinical Management of Bladder Cancer Patients. PMID:35205727
Hyperactivation of MAPK Induces Tamoxifen Resistance in SPRED2-Deficient ERα-Positive Breast Cancer. PMID:35205702
The Role of VHL in the Development of von Hippel-Lindau Disease and Erythrocytosis. PMID:35205407
PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy. PMID:35204749
Regulation of GTPase function by autophosphorylation. PMID:35202574
The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma. PMID:35201535
Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development. PMID:35198906
Internalization and trafficking of CSPG-bound recombinant VAR2CSA lectins in cancer cells. PMID:35197518
Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. PMID:35197475
IDH1/2 mutations in acute myeloid leukemia. PMID:35197370
Mutational Characteristics of Primary Mucosal Melanoma: A Systematic Review. PMID:35195858
The molecular characteristics of low-grade and high-grade areas in desmoplastic infantile astrocytoma/ganglioglioma. PMID:35191090
Disentangling the recognition complexity of a protein hub using a nanopore. PMID:35190547
NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model. PMID:35186194
BORIS-mediated generation of circular RNAs induces inflammation. PMID:35182955
New insights on familial colorectal cancer type X syndrome. PMID:35181726
Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics. PMID:35180770
Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium. PMID:35177608
Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation. PMID:35176222
Deciphering specific miRNAs in brain tumors: a 5-miRNA signature in glioblastoma. PMID:35175428
Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition. PMID:35173208
Machine learning for multi-omics data integration in cancer. PMID:35169688
Delineating the intra-patient heterogeneity of molecular alterations in treatment-naïve colorectal cancer with peritoneal carcinomatosis. PMID:35169225
Genion, an accurate tool to detect gene fusion from long transcriptomics reads. PMID:35164688
Identification of Early-Onset Metastasis in SF3B1 Mutated Uveal Melanoma. PMID:35159112
Disparities in Lung Cancer: miRNA Isoform Characterization in Lung Adenocarcinoma. PMID:35159038
RBM22, a Key Player of Pre-mRNA Splicing and Gene Expression Regulation, Is Altered in Cancer. PMID:35158909
Rare Occurrence of Aristolochic Acid Mutational Signatures in Oro-Gastrointestinal Tract Cancers. PMID:35158844
Over-Expression and Prognostic Significance of FATP5, as a New Biomarker, in Colorectal Carcinoma. PMID:35155561
Aberrant somatic hypermutation of CCND1 generates non-coding drivers of mantle cell lymphomagenesis. PMID:35145272
Somatic mutational profiles and germline polygenic risk scores in human cancer. PMID:35144655
Pan-Cancer Analyses Reveal Oncogenic Role and Prognostic Value of F-Box Only Protein 22. PMID:35141150
Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. PMID:35140400
Signatures of TOP1 transcription-associated mutagenesis in cancer and germline. PMID:35140396
A platform for oncogenomic reporting and interpretation. PMID:35140225
SCHOOL: Software for Clinical Health in Oncology for Omics Laboratories. PMID:35136669
ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance. PMID:35133980
Curated variation benchmarks for challenging medically relevant autosomal genes. PMID:35132260
New genetic variants of TET2 and ASXL1 identified by next generation sequencing and pyrosequencing in a patient with MDS-RS-MLD and secondary acute myeloid leukemia. PMID:35125953
Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial. PMID:35122060
Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse. PMID:35122027
Integrating molecular profiles into clinical frameworks through the Molecular Oncology Almanac to prospectively guide precision oncology. PMID:35121878
Prognostic value of Dickkopf-1 and ß-catenin expression according to the antitumor immunity of CD8-positive tumor-infiltrating lymphocytes in biliary tract cancer. PMID:35121803
Identification of neoantigens for individualized therapeutic cancer vaccines. PMID:35105974
Context dependency of nucleotide probabilities and variants in human DNA. PMID:35100973
Genomic patterns of transcription-replication interactions in mouse primary B cells. PMID:35100392
GenomeTornadoPlot: A novel R package for CNV visualization and focality analysis. PMID:35099519
Genomic landscape and immune-related gene expression profiling of epithelial ovarian cancer after neoadjuvant chemotherapy. PMID:35087175
Analytical Validation and Performance of a 7-Gene Next-Generation Sequencing Panel in Uveal Melanoma. PMID:35083209
Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource. PMID:35078504
An oncogenic splice variant of PDGFRα in adult glioblastoma as a therapeutic target for selective CDK4/6 inhibitors. PMID:35075231
Lung squamous cell carcinoma with rare epidermal growth factor receptor mutation G719X: a case report and literature review. PMID:35071499
Characterization With KRAS Mutant Is a Critical Determinant in Immunotherapy and Other Multiple Therapies for Non-Small Cell Lung Cancer. PMID:35070984
Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1. PMID:35070079
Discovering the key genes and important DNA methylation regions in breast cancer. PMID:35063044
Massively parallel phenotyping of coding variants in cancer with Perturb-seq. PMID:35058622
Identification of Survival-Specific Genes in Clear Cell Renal Cell Carcinoma Using a Customized Next-Generation Sequencing Gene Panel. PMID:35055428
Genomic Landscape of Vinflunine Response in Metastatic Urothelial Cancer. PMID:35053540
Noncoding RNAs and Deep Learning Neural Network Discriminate Multi-Cancer Types. PMID:35053515
Landscape of driver gene events, biomarkers, and druggable targets identified by whole-genome sequencing of glioblastomas. PMID:35047820
The path to the clinic: a comprehensive review on direct KRASG12C inhibitors. PMID:35045886
TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity. PMID:35045331
Effects of Oncohistone Mutations and PTM Crosstalk on the N-Terminal Acetylation Activities of NatD. PMID:35044762
PRODeepSyn: predicting anticancer synergistic drug combinations by embedding cell lines with protein-protein interaction network. PMID:35043159
Incidental germline findings during molecular profiling of tumor tissues for precision oncology: molecular survey and methodological obstacles. PMID:35033101
Analysis of genetic variants in myeloproliferative neoplasms using a 22-gene next-generation sequencing panel. PMID:35033063
The breast pre-cancer atlas illustrates the molecular and micro-environmental diversity of ductal carcinoma in situ. PMID:35027560
Single-cell analysis of somatic mutation burden in mammary epithelial cells of pathogenic BRCA1/2 mutation carriers. PMID:35025760
Age influences on the molecular presentation of tumours. PMID:35017538
A framework for mutational signature analysis based on DNA shape parameters. PMID:35015788
C/EBPβ promotes the expression of atrophy-inducing factors by tumours and is a central regulator of cancer cachexia. PMID:35014202
The insertion and dysregulation of transposable elements in osteosarcoma and their association with patient event-free survival. PMID:35013466
Integrated bioinformatics and experiments reveal the roles and driving forces for HSF1 in colorectal cancer. PMID:35006040
Case Report: Combination of Olaparib With Chemotherapy in a Patient With ATM-Deficient Colorectal Cancer. PMID:35004311
Phase I study using crenolanib to target PDGFR kinase in children and young adults with newly diagnosed DIPG or recurrent high-grade glioma, including DIPG. PMID:34993482
Universal annotation of the human genome through integration of over a thousand epigenomic datasets. PMID:34991667
Systematic analysis of the role of SLC52A2 in multiple human cancers. PMID:34991609
ScalpelSig Designs Targeted Genomic Panels from Data to Detect Activity of Mutational Signatures. PMID:34986026
Retinoblastoma protein regulates carcinogen susceptibility at heterochromatic cancer driver loci. PMID:34983823
A somatic UBA2 variant preceded ETV6-RUNX1 in the concordant BCP-ALL of monozygotic twins. PMID:34982829
A genomic mutation spectrum of collecting duct carcinoma in the Chinese population. PMID:34980126
KRAS Mutations in Squamous Cell Carcinomas of the Lung. PMID:34976827
Good Tumor Response to Chemoradioimmunotherapy in dMMR/MSI-H Advanced Colorectal Cancer: A Case Series. PMID:34975873
Sex- and mutation-specific p53 gain-of-function activity in gliomagenesis. PMID:34957471
Landscape and Clonal Dominance of Co-occurring Genomic Alterations in Non-Small-Cell Lung Cancer Harboring MET Exon 14 Skipping. PMID:34957368
9-ING-41, a Small Molecule Inhibitor of GSK-3β, Potentiates the Effects of Chemotherapy on Colorectal Cancer Cells. PMID:34955846
Anticancer drug resistance: An update and perspective. PMID:34953682
Genomic landscape of Epstein-Barr virus-positive extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue. PMID:34952945
GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease. PMID:34948182
Arginine Depletion in Human Cancers. PMID:34944895
The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene. PMID:34943931
Translesion DNA synthesis-driven mutagenesis in very early embryogenesis of fast cleaving embryos. PMID:34939656
Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001. PMID:34933343
Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes. PMID:34932938
RB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes. PMID:34932500
Prioritising positively selected variants in whole-genome sequencing data using FineMAV. PMID:34922440
Induction of mismatch repair deficiency, compromised DNA damage signaling and compound hypermutagenesis by a dietary mutagen in a cell-based model for Lynch syndrome. PMID:34919656
Driving mosaicism: somatic variants in reference population databases and effect on variant interpretation in rare genetic disease. PMID:34906245
gcMECM: graph clustering of mutual exclusivity of cancer mutations. PMID:34906079
Pathway Enrichment Analysis of Microarray Data. PMID:34902127
Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics. PMID:34900668
MLL4 mediates differentiation and tumor suppression through ferroptosis. PMID:34890228
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1. PMID:34887559
Accurate detection of circulating tumor DNA using nanopore consensus sequencing. PMID:34887408
Bridging the Species Gap: Morphological and Molecular Comparison of Feline and Human Intestinal Carcinomas. PMID:34885050
Integration of Mutational Signature Analysis with 3D Chromatin Data Unveils Differential AID-Related Mutagenesis in Indolent Lymphomas. PMID:34884820
Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair. PMID:34879271
The histologic phenotype of lung cancers is associated with transcriptomic features rather than genomic characteristics. PMID:34873156
Therapeutic Response-Based Reclassification of Multiple Tumor Subtypes Reveals Intrinsic Molecular Concordance of Therapy Across Histologically Disparate Cancers. PMID:34869372
Atypical Chronic Myelogenous Leukemia, BCR-ABL1 Negative: Diagnostic Criteria and Treatment Approaches. PMID:34868917
Compendium of human transcription factor effector domains. PMID:34863368
Discovery of clinically relevant fusions in pediatric cancer. PMID:34863095
Genomic and clinical findings in myeloid neoplasms with PDGFRB rearrangement. PMID:34859285
An Integrative Pan-Cancer Analysis of PBK in Human Tumors. PMID:34859049
Calcium sensing receptor stimulates breast cancer cell migration via the Gβγ-AKT-mTORC2 signaling pathway. PMID:34854057
miRTarBase update 2022: an informative resource for experimentally validated miRNA-target interactions. PMID:34850920
Evolution under Spatially Heterogeneous Selection in Solid Tumors. PMID:34850073
Genomic mutation features identify distinct BRCA-associated mutation characteristics in endometrioid carcinoma and endometrioid ovarian carcinoma. PMID:34837690
Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes. PMID:34836952
Integration and Visualization of Regulatory Elements and Variations of the EPAS1 Gene in Human. PMID:34828399
Genomic and experimental evidence that ALKATI does not predict single agent sensitivity to ALK inhibitors. PMID:34825133
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture. PMID:34824211
The effect of S427F mutation on RXRα activity depends on its dimeric partner. PMID:34820085
Structural basis for ligand reception by anaplastic lymphoma kinase. PMID:34819665
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer. PMID:34819353
Prognostic value of circulating tumour DNA in metastatic pancreatic cancer patients: post-hoc analyses of two clinical trials. PMID:34811505
Super-Resolution Microscopy Reveals That Stromal Interaction Molecule 1 Trafficking Depends on Microtubule Dynamics. PMID:34803742
Combination of Type I and Type II MET Tyrosine Kinase Inhibitors as Therapeutic Approach to Prevent Resistance. PMID:34789563
Molecular Characterization of Dysplasia-Initiated Colorectal Cancer With Assessing Matched Tumor and Dysplasia Samples. PMID:34788527
CSNK2 in cancer: pathophysiology and translational applications. PMID:34773100
Clinical Value of NGS Genomic Studies for Clinical Management of Pediatric and Young Adult Bone Sarcomas. PMID:34771600
Growth of Biological Complexity from Prokaryotes to Hominids Reflected in the Human Genome. PMID:34769071
Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue. PMID:34767620
Structural variants in the Chinese population and their impact on phenotypes, diseases and population adaptation. PMID:34764282
Origins and evolution of extreme life span in Pacific Ocean rockfishes. PMID:34762458
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance. PMID:34750265
Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine. PMID:34749812
Pol3Base: a resource for decoding the interactome, expression, evolution, epitranscriptome and disease variations of Pol III-transcribed ncRNAs. PMID:34747466
Conversion Surgery for Advanced Thoracic SMARCA4-Deficient Undifferentiated Tumor With Atezolizumab in Combination With Bevacizumab, Paclitaxel, and Carboplatin Treatment: A Case Report. PMID:34746887
New Regions With Molecular Alterations in a Rare Case of Insulinomatosis: Case Report With Literature Review. PMID:34737724
Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine. PMID:34737276
A novel strategy for combination of clofarabine and pictilisib is synergistic in gastric cancer. PMID:34735897
Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene. PMID:34735543
Artificial Intelligence, Machine Learning, and Deep Learning in Real-Life Drug Design Cases. PMID:34731478
Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer. PMID:34729943
Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair. PMID:34728620
Simulation studies, 3D QSAR and molecular docking on a point mutation of protein kinase B with flavonoids targeting ovarian Cancer. PMID:34727985
A mixture model for signature discovery from sparse mutation data. PMID:34724984
RPS: a comprehensive database of RNAs involved in liquid-liquid phase separation. PMID:34718734
ConVarT: a search engine for matching human genetic variants with variants from non-human species. PMID:34718716
Mouse-INtraDuctal (MIND): an in vivo model for studying the underlying mechanisms of DCIS malignancy. PMID:34714554
Urine TERT promoter mutations-based tumor DNA detection in patients with bladder cancer: A pilot study. PMID:34712485
Pharmacogenomics characterization of the MDM2 inhibitor MI-773 reveals candidate tumours and predictive biomarkers. PMID:34711913
Blast cells surviving acute myeloid leukemia induction therapy are in cycle with a signature of FOXM1 activity. PMID:34711181
Dissecting the Pathogenesis of Diabetic Retinopathy Based on the Biological ceRNA Network and Genome Variation Disturbance. PMID:34707685
Everything Old Is New Again: Drug Repurposing Approach for Non-Small Cell Lung Cancer Targeting MAPK Signaling Pathway. PMID:34692523
Omics and Computational Modeling Approaches for the Effective Treatment of Drug-Resistant Cancer Cells. PMID:34691155
MYCN and MAX alterations in Wilms tumor and identification of novel N-MYC interaction partners as biomarker candidates. PMID:34689785
Recent innovations and in-depth aspects of post-genome wide association study (Post-GWAS) to understand the genetic basis of complex phenotypes. PMID:34689168
Naturally occurring cancer-associated mutations disrupt oligomerization and activity of protein arginine methyltransferase 1 (PRMT1). PMID:34688662
Distinct Clinical Impact and Biological Function of Angiopoietin and Angiopoietin-like Proteins in Human Breast Cancer. PMID:34685578
ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer. PMID:34685488
Improved SNV Discovery in Barcode-Stratified scRNA-seq Alignments. PMID:34680953
Integrative Map of HIF1A Regulatory Elements and Variations. PMID:34680921
Molecular Signature Expands the Landscape of Driver Negative Thyroid Cancers. PMID:34680332
Development and Validation of Targeted Gene Sequencing Panel Based Companion Diagnostic for Korean Patients with Solid Tumors. PMID:34680263
PPARγ Targets-Derived Diagnostic and Prognostic Index for Papillary Thyroid Cancer. PMID:34680260
The Evolution of Clinically Aggressive Triple-Negative Breast Cancer Shows a Large Mutational Diversity and Early Metastasis to Lymph Nodes. PMID:34680239
(In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers. PMID:34680193
p53 Forms Redox-Dependent Protein-Protein Interactions through Cysteine 277. PMID:34679713
Investigating single amino acid substitutions in PIM1 kinase: A structural genomics approach. PMID:34679086
The experiences and needs of Australian medical oncologists in integrating comprehensive genomic profiling into clinical care: a nation-wide survey. PMID:34676049
Prediction of severe adverse events, modes of action and drug treatments for COVID-19's complications. PMID:34675303
Identifying a cervical cancer survival signature based on mRNA expression and genome-wide copy number variations. PMID:34674573
Pan-Cancer Analysis of the Associations of TGFBI Expression With Prognosis and Immune Characteristics. PMID:34671645
Global quantification exposes abundant low-level off-target activity by base editors. PMID:34667118
PIK3CA mutation in a case of CTNNB1-mutant sinonasal glomangiopericytoma. PMID:34667073
A data-driven approach for constructing mutation categories for mutational signature analysis. PMID:34665813
Dissecting single-cell genomes through the clonal organoid technique. PMID:34663940
Molecular and genomic characterisation of a panel of human anal cancer cell lines. PMID:34663790
Network potential identifies therapeutic miRNA cocktails in Ewing sarcoma. PMID:34662337
Prognostic Value and Immunological Role of MORF4-Related Gene-Binding Protein in Human Cancers. PMID:34660575
Comprehensive landscape and interference of clonal haematopoiesis mutations for liquid biopsy: A Chinese pan-cancer cohort. PMID:34658138
DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes. PMID:34654425
Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers. PMID:34649609
Liquid Biopsy in Gastric Cancer: Analysis of Somatic Cancer Tissue Mutations in Plasma Cell-Free DNA for Predicting Disease State and Patient Survival. PMID:34644276
Aortic root dilatation and dilated cardiomyopathy in an adult with Tatton-Brown-Rahman syndrome. PMID:34644003
Targeted Sequencing Revealed Distinct Mutational Profiles of Ocular and Extraocular Sebaceous Carcinomas. PMID:34638295
Role of Circulating Tumor DNA in Gastrointestinal Cancers: Current Knowledge and Perspectives. PMID:34638228
Immune pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma. PMID:34635775
SomaMutDB: a database of somatic mutations in normal human tissues. PMID:34634815
A Pan-Cancer Analysis of SLC12A5 Reveals Its Correlations with Tumor Immunity. PMID:34630736
Toward a methodology for evaluating DNA variants in nuclear families. PMID:34624066
ESR1 mutations and therapeutic resistance in metastatic breast cancer: progress and remaining challenges. PMID:34621045
Network propagation-based prioritization of long tail genes in 17 cancer types. PMID:34620211
Histopathologic, immunophenotypic, and mutational landscape of follicular lymphomas with plasmacytic differentiation. PMID:34601504
Somatic IDH1 variant (p.R132C) in an adult male with Maffucci syndrome. PMID:34588213
t(4;12)(q12;p13) ETV6-rearranged AML without eosinophilia does not involve PDGFRA: relevance for imatinib insensitivity. PMID:34587239
The multifaceted role of lemur tyrosine kinase 3 in health and disease. PMID:34582708
Bilineal evolution of a U2AF1-mutated clone associated with acquisition of distinct secondary mutations. PMID:34581783
Molecular Alterations in Meningioangiomatosis Causing Epilepsy. PMID:34580720
Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in Cancer. PMID:34576340
Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species. PMID:34570764
VannoPortal: multiscale functional annotation of human genetic variants for interrogating molecular mechanism of traits and diseases. PMID:34570217
Pan-cancer evaluation of gene expression and somatic alteration data for cancer prognosis prediction. PMID:34563154
Comparative analyses of aging-related genes in long-lived mammals provide insights into natural longevity. PMID:34557758
Liquid biopsy with droplet digital PCR targeted to specific mutations in plasma cell-free tumor DNA can detect ovarian cancer recurrence earlier than CA125. PMID:34557579
Multiomics Analysis of Neuroblastoma Cells Reveals a Diversity of Malignant Transformations. PMID:34557494
Molecular basis of human ATM kinase inhibition. PMID:34556870
SCReadCounts: estimation of cell-level SNVs expression from scRNA-seq data. PMID:34551708
Sporadic adamantinomatous craniopharyngioma with double-hit somatic APC mutations. PMID:34549183
Predicting cancer drug TARGETS - TreAtment Response Generalized Elastic-neT Signatures. PMID:34548481
Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma. PMID:34545084
circMine: a comprehensive database to integrate, analyze and visualize human disease-related circRNA transcriptome. PMID:34530446
ASXL1 and STAG2 are common mutations in GATA2 deficiency patients with bone marrow disease and myelodysplastic syndrome. PMID:34529785
The reversed intra- and extracellular pH in tumors as a unified strategy to chemotherapeutic delivery using targeted nanocarriers. PMID:34522586
The genomic profiling and MAMLD1 expression in human and canines with Cushing's disease. PMID:34517852
Evolution of Functional Diversity in the Holozoan Tyrosine Kinome. PMID:34515793
Copy Number Signatures and Clinical Outcomes in Upper Tract Urothelial Carcinoma. PMID:34513842
Recognizing Pattern and Rule of Mutation Signatures Corresponding to Cancer Types. PMID:34513841
Consistent B Cell Receptor Immunoglobulin Features Between Siblings in Familial Chronic Lymphocytic Leukemia. PMID:34513715
Integrative analysis reveals clinically relevant molecular fingerprints in pancreatic cancer. PMID:34513290
Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases. PMID:34507989
SWnet: a deep learning model for drug response prediction from cancer genomic signatures and compound chemical structures. PMID:34507532
Whole-Genome Analysis of De Novo Somatic Point Mutations Reveals Novel Mutational Biomarkers in Pancreatic Cancer. PMID:34503185
The Prognostic Effect of KRAS Mutations in Non-Small Cell Lung Carcinoma Revisited: A Norwegian Multicentre Study. PMID:34503114
A Genome-Wide Profiling of Glioma Patients with an IDH1 Mutation Using the Catalogue of Somatic Mutations in Cancer Database. PMID:34503108
Therapeutic cancer vaccines revamping: technology advancements and pitfalls. PMID:34500046
Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients. PMID:34496298
Genomic and epigenomic evolution of acquired resistance to combination therapy in esophageal squamous cell carcinoma. PMID:34494553
Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis. PMID:34493325
A scalable Drosophila assay for clinical interpretation of human PTEN variants in suppression of PI3K/AKT induced cellular proliferation. PMID:34492006
Prognostic role of EGR1 in breast cancer: a systematic review. PMID:34488929
Integrated evaluation of telomerase activation and telomere maintenance across cancer cell lines. PMID:34486523
Host-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural process. PMID:34485968
Prospects and challenges of cancer systems medicine: from genes to disease networks. PMID:34471925
Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy. PMID:34467251
Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma. PMID:34465776
Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study. PMID:34464379
Systematic Analysis of Cytostatic TGF-Beta Response in Mesenchymal-Like Hepatocellular Carcinoma Cell Lines. PMID:34463913
The chemical biology of coronavirus host-cell interactions. PMID:34458775
Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation. PMID:34452907
Transcriptional Regulation of RUNX1: An Informatics Analysis. PMID:34440349
Extracellular Vesicle-Derived DNA vs. CfDNA as a Biomarker for the Detection of Colon Cancer. PMID:34440345
Comprehensive Genetic Analysis of DGAT2 Mutations and Gene Expression Patterns in Human Cancers. PMID:34439946
Biomolecule and Bioentity Interaction Databases in Systems Biology: A Comprehensive Review. PMID:34439912
Clinical Perspectives of Single-Cell RNA Sequencing. PMID:34439827
Computational Approaches for Cancer-Fighting: From Gene Expression to Functional Foods. PMID:34439361
Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAFV600E-Mutant Human Glioma. PMID:34433654
HPLC method to resolve, identify and quantify guanine nucleotides bound to recombinant ras GTPase. PMID:34433016
Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment. PMID:34429404
Characterizing miRNA-lncRNA Interplay. PMID:34417757
Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction. PMID:34417497
Histone Methyltransferases Useful in Gastric Cancer Research. PMID:34413625
Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion. PMID:34413465
Sclerosing Polycystic Adenoma: Conclusive Clinical and Molecular Evidence of Its Neoplastic Nature. PMID:34410594
Androgen signaling connects short isoform production to breakpoint formation at Ewing sarcoma breakpoint region 1. PMID:34409300
Assessing acute myeloid leukemia susceptibility in rearrangement-driven patients by DNA breakage at topoisomerase II and CCCTC-binding factor/cohesin binding sites. PMID:34405474
Novel somatic variants involved in biochemical activity of pure growth hormone-secreting pituitary adenoma without GNAS variant. PMID:34400688
Two progressed malignant phyllodes tumors of the breast harbor alterations in genes frequently involved in other advanced cancers. PMID:34399808
Machine Learning Identifies Clinical and Genetic Factors Associated With Anthracycline Cardiotoxicity in Pediatric Cancer Survivors. PMID:34396283
Rates and Patterns of Clonal Oncogenic Mutations in the Normal Human Brain. PMID:34389641
Genome-wide mapping of binding sites of the transposase-derived SETMAR protein in the human genome. PMID:34377368
Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma. PMID:34376672
Phase Ib study of patients with metastatic castrate-resistant prostate cancer treated with different sequencing regimens of atezolizumab and sipuleucel-T. PMID:34376554
Phosphoinositide Recognition Sites Are Blocked by Metabolite Attachment. PMID:34368138
A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival. PMID:34363019
HER Tyrosine Kinase Family and Rhabdomyosarcoma: Role in Onset and Targeted Therapy. PMID:34359977
A proteogenomic portrait of lung squamous cell carcinoma. PMID:34358469
Somatic Tumor Profile Analysis in a Patient with Germline PMS2 Mutation and Synchronous Ovarian and Uterine Carcinomas. PMID:34357101
Molecular and Pathological Profiling of Corresponding Treatment-Naïve and Neoadjuvant Pazopanib-Treated High-Risk Soft Tissue Sarcoma Samples of the GISG-04/NOPASS Study. PMID:34356494
Merida: a novel boolean logic based integer linear program for personalized cancer therapy. PMID:34352075
A domain damage index to prioritizing the pathogenicity of missense variants. PMID:34350656
DNA and RNA Sequencing Recapitulated Aberrant Tumor Metabolism in Liver Cancer Cell Lines. PMID:34350138
Identification of Variants Associated With Rare Hematological Disorder Erythrocytosis Using Targeted Next-Generation Sequencing Analysis. PMID:34349782
Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma. PMID:34349258
Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice. PMID:34348785
Identification of HCC-Related Genes Based on Differential Partial Correlation Network. PMID:34335688
Co-Occurrence of Familial Non-Medullary Thyroid Cancer (FNMTC) and Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Associated Tumors-A Cohort Study. PMID:34326811
Large scale clinical exome sequencing uncovers the scope and severity of skin disorders associated with MC1R genetic variants. PMID:34326492
Germ-line mutations in WDR77 predispose to familial papillary thyroid cancer. PMID:34326253
The repair gene BACH1 - a potential oncogene. PMID:34322202
Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal. PMID:34321462
Characterization of DNA lesions associated with cell-free DNA by targeted deep sequencing. PMID:34320984
Tumor Mutation Burden Prediction Model in Egyptian Breast Cancer patients based on Next Generation Sequencing. PMID:34319027
Next-Generation Sequencing Concordance Analysis of Comprehensive Solid Tumor Profiling between a Centralized Specialty Laboratory and the Decentralized Personal Genome Diagnostics elio Tissue Complete Kitted Solution. PMID:34314880
VarSAn: associating pathways with a set of genomic variants using network analysis. PMID:34313777
Pan-Cancer Survey of Tumor Mass Dormancy and Underlying Mutational Processes. PMID:34307377
Immunopeptidomics-Guided Warehouse Design for Peptide-Based Immunotherapy in Chronic Lymphocytic Leukemia. PMID:34305947
The Genomic Landscape of a Restricted ALL Cohort from Patients Residing on the U.S./Mexico Border. PMID:34299796
The Structural Effect of FLT3 Mutations at 835th Position and Their Interaction with Acute Myeloid Leukemia Inhibitors: In Silico Approach. PMID:34299222
Comprehensive Genomic and Transcriptomic Analysis of Three Synchronous Primary Tumours and a Recurrence from a Head and Neck Cancer Patient. PMID:34299215
Exploring Differentially Methylated Genes in Vulvar Squamous Cell Carcinoma. PMID:34298793
Methyltransferases in the Pathogenesis of Keratinocyte Cancers. PMID:34298617
Detection of circulating tumor DNA without a tumor-informed search using next-generation sequencing is a prognostic biomarker in pancreatic ductal adenocarcinoma. PMID:34298235
Autocrine signaling by receptor tyrosine kinases in urothelial carcinoma of the bladder. PMID:34292953
Co-evolutionary landscape at the interface and non-interface regions of protein-protein interaction complexes. PMID:34285778
Antitumor efficacy of XPO1 inhibitor Selinexor in KRAS-mutant lung adenocarcinoma patient-derived xenografts. PMID:34284202
A pan-cancer landscape of somatic mutations in non-unique regions of the human genome. PMID:34282324
Functional annotation of noncoding mutations in cancer. PMID:34282050
Revealing macropinocytosis using nanoparticles. PMID:34281720
Germline ERBB3 mutation in familial non-small-cell lung carcinoma: expanding ErbB's role in oncogenesis. PMID:34274969
Haplotype-resolved germline and somatic alterations in renal medullary carcinomas. PMID:34261517
Somatic mutations in benign breast disease tissues and association with breast cancer risk. PMID:34261476
CNVIntegrate: the first multi-ethnic database for identifying copy number variations associated with cancer. PMID:34259866
Functional genomics approaches to improve pre-clinical drug screening and biomarker discovery. PMID:34254730
ctDNA MRD Detection and Personalized Oncogenomic Analysis in Oligometastatic Colorectal Cancer From Plasma and Urine. PMID:34250420
Alpelisib and radiotherapy treatment enhances Alisertib-mediated cervical cancer tumor killing. PMID:34249458
Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors. PMID:34235003
Non-coding driver mutations in human cancer. PMID:34230647
Applicability of liquid biopsies to represent the mutational profile of tumor tissue from different cancer entities. PMID:34230613
Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer. PMID:34223403
Identification and Characterization of Non-Coding RNAs in Thymoma. PMID:34219124
Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis. PMID:34215846
A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated prostate cancer. PMID:34211036
Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome. PMID:34210977
Poorly Differentiated and Anaplastic Thyroid Cancer: Insights into Genomics, Microenvironment and New Drugs. PMID:34206867
NGS-Based Analysis of Atypical Deep Penetrating Nevi. PMID:34205480
Identifying Cancer Drivers Using DRIVE: A Feature-Based Machine Learning Model for a Pan-Cancer Assessment of Somatic Missense Mutations. PMID:34205004
Targeted Sequencing of Taiwanese Breast Cancer with Risk Stratification by the Concurrent Genes Signature: A Feasibility Study. PMID:34203389
Histone H3K4 Methyltransferases as Targets for Drug-Resistant Cancers. PMID:34201935
Increased Tumor Growth Rate and Mesenchymal Properties of NSCLC-Patient-Derived Xenograft Models during Serial Transplantation. PMID:34198671
Functional and structural analyses of novel Smith-Kingsmore Syndrome-Associated MTOR variants reveal potential new mechanisms and predictors of pathogenicity. PMID:34197453
Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma. PMID:34193180
Profiling of host genetic alterations and intra-tumor microbiomes in colorectal cancer. PMID:34188781
The effect of protein mutations on drug binding suggests ensuing personalised drug selection. PMID:34188094
Identification and monitoring of mutations in circulating cell-free tumor DNA in hepatocellular carcinoma treated with lenvatinib. PMID:34174931
Aggressive early-stage lung adenocarcinoma is characterized by epithelial cell plasticity with acquirement of stem-like traits and immune evasion phenotype. PMID:34172935
Identification and Validation of T-cell Receptors Targeting RAS Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy. PMID:34168045
A computational method for prioritizing targeted therapies in precision oncology: performance analysis in the SHIVA01 trial. PMID:34162980
LncRNAs and Available Databases. PMID:34160796
Mobile element insertions and associated structural variants in longitudinal breast cancer samples. PMID:34158539
Frequent POLE-driven hypermutation in ovarian endometrioid cancer revealed by mutational signatures in RNA sequencing. PMID:34158040
Distal chromosome 1q aberrations and initial response to ibrutinib in central nervous system relapsed mantle cell lymphoma. PMID:34150491
Establishment and characterization of immortalized human breast cancer cell lines from breast cancer patient-derived xenografts (PDX). PMID:34145270
COSMIC Cancer Gene Census 3D database: understanding the impacts of mutations on cancer targets. PMID:34137435
BAX mitochondrial integration is regulated allosterically by its α1-α2 loop. PMID:34135480
Learning mutational signatures and their multidimensional genomic properties with TensorSignatures. PMID:34131135
Pan-cancer analysis of CD274 (PD-L1) mutations in 314,631 patient samples and subset correlation with PD-L1 protein expression. PMID:34130989
High-throughput surface marker screen on primary human breast tissues reveals further cellular heterogeneity. PMID:34120626
Efficient representations of tumor diversity with paired DNA-RNA aberrations. PMID:34115745
Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course. PMID:34113563
Single-Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids. PMID:34105295
Anti-PD-1 elicits regression of undifferentiated pleomorphic sarcomas with UV-mutation signatures. PMID:34103354
Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival. PMID:34099491
A novel genomic classification system of gastric cancer via integrating multidimensional genomic characteristics. PMID:34095982
Reciprocal priming between receptor tyrosine kinases at recycling endosomes orchestrates cellular signalling outputs. PMID:34086370
Alterations in Chromatin Folding Patterns in Cancer Variant-Enriched Loci. PMID:34085045
Translesion Synthesis Past 5-Formylcytosine-Mediated DNA-Peptide Cross-Links by hPolη Is Dependent on the Local DNA Sequence. PMID:34080848
Genomic and Transcriptomic Characterization of Canine Osteosarcoma Cell Lines: A Valuable Resource in Translational Medicine. PMID:34079834
Transcriptomic heterogeneity of driver gene mutations reveals novel mutual exclusivity and improves exploration of functional associations. PMID:34076361
Mechnetor: a web server for exploring protein mechanism and the functional context of genetic variants. PMID:34076240
Yeast-based screening of cancer mutations in the DNA damage response protein Mre11 demonstrates importance of conserved capping domain residues. PMID:34075539
Diagnostic and Prognostic Value of Circulating Cell-Free DNA for Cholangiocarcinoma. PMID:34070951
Molecular Landscape and Therapeutic Strategies in Cholangiocarcinoma: An Integrated Translational Approach towards Precision Medicine. PMID:34070643
Regulation of the Phosphoinositide Code by Phosphorylation of Membrane Readers. PMID:34069055
Stability across the Whole Nuclear Genome in the Presence and Absence of DNA Mismatch Repair. PMID:34067668
Cell-Free DNA Analysis by Whole-Exome Sequencing for Hepatocellular Carcinoma: A Pilot Study in Thailand. PMID:34066484
KEAP1 Cancer Mutants: A Large-Scale Molecular Dynamics Study of Protein Stability. PMID:34065616
RLIP76: A Structural and Functional Triumvirate. PMID:34064388
Analysis and Interpretation of the Impact of Missense Variants in Cancer. PMID:34063805
The Multiple Facets of ATRX Protein. PMID:34062956
Prostate cancer risk variants of the HOXB genetic locus. PMID:34059701
X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology. PMID:34056803
MTR3D: identifying regions within protein tertiary structures under purifying selection. PMID:34050760
AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression. PMID:34041018
Enhancer release and retargeting activates disease-susceptibility genes. PMID:34040254
Somatic PIK3R1 variation as a cause of vascular malformations and overgrowth. PMID:34040190
Unraveling Neuroendocrine Gallbladder Cancer: Comprehensive Clinicopathologic and Molecular Characterization. PMID:34036234
Sensitivity, specificity, and accuracy of a liquid biopsy approach utilizing molecular amplification pools. PMID:34031447
driveR: a novel method for prioritizing cancer driver genes using somatic genomics data. PMID:34030627
Large-Scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers. PMID:34027416
Identification of combinations of somatic mutations that predict cancer survival and immunotherapy benefit. PMID:34027407
Characterizing the molecular and immune landscape of canine bladder cancer. PMID:34021685
FUS oncofusion protein condensates recruit mSWI/SNF chromatin remodeler via heterotypic interactions between prion-like domains. PMID:34018649
Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma. PMID:34015961
Characterization and comparison of gene-centered human interactomes. PMID:34010955
Protein synthesis inhibitor omacetaxine is effective against hepatocellular carcinoma. PMID:34003798
Combined Blockade of MEK and CDK4/6 Pathways Induces Senescence to Improve Survival in Pancreatic Ductal Adenocarcinoma. PMID:34001634
The emerging role of the KCTD proteins in cancer. PMID:34001146
Chaperonin-Containing TCP1 Complex (CCT) Promotes Breast Cancer Growth Through Correlations With Key Cell Cycle Regulators. PMID:33996588
HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1. PMID:33990627
Crystal structure and mutational analysis of the human TRIM7 B30.2 domain provide insights into the molecular basis of its binding to glycogenin-1. PMID:33989636
The landscape and driver potential of site-specific hotspots across cancer genomes. PMID:33986299
Crinet: A computational tool to infer genome-wide competing endogenous RNA (ceRNA) interactions. PMID:33983999
Role of Chromodomain-Helicase-DNA-Binding Protein 4 (CHD4) in Breast Cancer. PMID:33981601
Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer. PMID:33981003
Landscape of allele-specific transcription factor binding in the human genome. PMID:33980847
Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion. PMID:33980181
Ras Variant Biology and Contributions to Human Disease. PMID:33977468
Investigation of product-derived lymphoma following infusion of piggyBac-modified CD19 chimeric antigen receptor T cells. PMID:33974080
Application of the conventional and novel methods in testing EGFR variants for NSCLC patients in the last 10 years through different regions: a systematic review. PMID:33973139
MLKL in cancer: more than a necroptosis regulator. PMID:33953348
SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site. PMID:33953332
Comprehensive CRISPR-Cas9 screens identify genetic determinants of drug responsiveness in multiple myeloma. PMID:33950175
SLF1 polymorphism predicts response to oxaliplatin-based adjuvant chemotherapy in patients with colon cancer. PMID:33948371
A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells. PMID:33941937
Single nucleotide polymorphism array-based signature of low hypodiploidy in acute lymphoblastic leukemia. PMID:33938069
Molecular Profiling-Based Assignment of Cancer Therapy (NCI-MPACT): A Randomized Multicenter Phase II Trial. PMID:33928209
A Panel of Five-lncRNA Signature as a Potential Biomarker for Predicting Survival in Gastric and Thoracic Cancers. PMID:33927753
NEPdb: A Database of T-Cell Experimentally-Validated Neoantigens and Pan-Cancer Predicted Neoepitopes for Cancer Immunotherapy. PMID:33927717
Ten-eleven translocation protein 1 modulates medulloblastoma progression. PMID:33926529
Prognostic Impact of APOBEC3B Expression in Metastatic Urothelial Carcinoma and Its Association with Tumor-Infiltrating Cytotoxic T Cells. PMID:33925044
Characterization of the Survival Influential Genes in Carcinogenesis. PMID:33922264
The Molecular Landscape of Primary Acral Melanoma: A Multicenter Study of the Italian Melanoma Intergroup (IMI). PMID:33917086
Next Generation Sequencing Technology in the Clinic and Its Challenges. PMID:33916923
DPP9: Comprehensive In Silico Analyses of Loss of Function Gene Variants and Associated Gene Expression Signatures in Human Hepatocellular Carcinoma. PMID:33915844
Targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer. PMID:33907296
Genomic profile of advanced breast cancer in circulating tumour DNA. PMID:33893289
Leukemia Cells Resistant to Glutamine Deprivation Express Glutamine Synthetase Protein. PMID:33882633
Typical 22q11.2 deletion syndrome appears to confer a reduced risk of schwannoma. PMID:33879870
An integrative analysis of the age-associated multi-omic landscape across cancers. PMID:33879792
CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSα/ATM-p73 axis in bladder cancer. PMID:33874956
The Metabolic Landscape of RAS-Driven Cancers from biology to therapy. PMID:33870211
Rational antibody design for undruggable targets using kinetically controlled biomolecular probes. PMID:33863724
A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency. PMID:33863366
Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis. PMID:33859162
CRL4AMBRA1 is a master regulator of D-type cyclins. PMID:33854235
Structural basis of long-range to short-range synaptic transition in NHEJ. PMID:33854234
Type IV Collagen Variants in CKD: Performance of Computational Predictions for Identifying Pathogenic Variants. PMID:33851121
Panels and models for accurate prediction of tumor mutation burden in tumor samples. PMID:33850256
Mechanistic Differences of Activation of Rac1P29S and Rac1A159V. PMID:33848152
Epigenetic and metabolic interplay in cutaneous squamous cell carcinoma. PMID:33844325
Are all ALK variants created equal? Clinicopathologic features and outcomes: a propensity-matched study. PMID:33844110
PIK3CA Mutations as a Molecular Target for Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer. PMID:33842357
Genetic alterations in Thai adult patients with acute myeloid leukemia and myelodysplastic syndrome-excess blasts detected by next-generation sequencing technique. PMID:33839881
Low-level variant calling for non-matched samples using a position-based and nucleotide-specific approach. PMID:33832433
Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML. PMID:33831168
Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations. PMID:33823788
Exons and introns exhibit transcriptional strand asymmetry of dinucleotide distribution, damage formation and DNA repair. PMID:33817640
Constitutional 2p16.3 deletion including MSH6 and FBXO11 in a boy with developmental delay and diffuse large B-cell lymphoma. PMID:33811277
Comprehensive Genomic Characterization of Fifteen Early-Onset Lynch-Like Syndrome Colorectal Cancers. PMID:33809179
Structural Basis for the Functional Changes by EGFR Exon 20 Insertion Mutations. PMID:33807850
Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival. PMID:33807330
Quantitative Proteomics Analysis of Berberine-Treated Colon Cancer Cells Reveals Potential Therapy Targets. PMID:33806918
A Review of Genetic Abnormalities in Unicentric and Multicentric Castleman Disease. PMID:33804823
Approaches to Identify and Characterise the Post-Transcriptional Roles of lncRNAs in Cancer. PMID:33803328
A Detailed Catalogue of Multi-Omics Methodologies for Identification of Putative Biomarkers and Causal Molecular Networks in Translational Cancer Research. PMID:33802234
Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations. PMID:33796225
Systematic prediction of drug resistance caused by transporter genes in cancer cells. PMID:33795761
Dramatic Responses of Recurrent Upper Urinary Tract Urothelial Carcinoma Harboring FGFR3 and TP53 Activating Mutations to Pembrolizumab in Combination with Erdafitinib: A Case Report. PMID:33790580
Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias. PMID:33786584
Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia. PMID:33785863
Myeloproliferative neoplasm-driving Calr frameshift promotes the development of pulmonary hypertension in mice. PMID:33785036
A selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in Saccharomyces cerevisiae. PMID:33784385
Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice. PMID:33782605
Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth. PMID:33782401
Mutational Profile and Clonal Evolution of Relapsed/Refractory Diffuse Large B-Cell Lymphoma. PMID:33777778
OncoGEMINI: software for investigating tumor variants from multiple biopsies with integrated cancer annotations. PMID:33771218
Potential Impact of DPYD Variation on Fluoropyrimidine Drug Response in sub-Saharan African Populations. PMID:33767731
Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles. PMID:33764464
GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase. PMID:33762003
In-utero exposure to zidovudine-containing antiretroviral therapy and clonal hematopoiesis in HIV-exposed uninfected newborns. PMID:33756513
Mutational spectrum and precision oncology for biliary tract carcinoma. PMID:33754015
The origins and genetic interactions of KRAS mutations are allele- and tissue-specific. PMID:33753749
Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis. PMID:33743547
A DNA repair disorder caused by de novo monoallelic DDB1 variants is associated with a neurodevelopmental syndrome. PMID:33743206
Short and long-read genome sequencing methodologies for somatic variant detection; genomic analysis of a patient with diffuse large B-cell lymphoma. PMID:33742045
Landmarks of human embryonic development inscribed in somatic mutations. PMID:33737485
EIF3F-related neurodevelopmental disorder: refining the phenotypic and expanding the molecular spectrum. PMID:33736665
Mutational profiles of marker genes of cervical carcinoma in Bangladeshi patients. PMID:33736612
High mutation burden in the checkpoint and micro-RNA processing genes in myelodysplastic syndrome. PMID:33730109
Single-copy detection of somatic variants from solid and liquid biopsy. PMID:33727644
Do Molecular Profiles of Primary Versus Metastatic Radioiodine Refractory Differentiated Thyroid Cancer Differ? PMID:33716974
The role of WDR76 protein in human diseases. PMID:33714259
Characterization of in vitro models of SLC30A10 deficiency. PMID:33713241
Malfeasance of KRAS mutations in carcinogenesis. PMID:33709341
Establishment and genomic characterization of a sporadic malignant peripheral nerve sheath tumor cell line. PMID:33707600
Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia. PMID:33707421
Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor. PMID:33705793
Functional impact of cancer-associated cohesin variants on gene expression and cellular identity. PMID:33704438
Significant non-existence of sequences in genomes and proteomes. PMID:33693858
CD96 Correlates With Immune Infiltration and Impacts Patient Prognosis: A Pan-Cancer Analysis. PMID:33680972
FOXM1 and Cancer: Faulty Cellular Signaling Derails Homeostasis. PMID:33680951
DriverSubNet: A Novel Algorithm for Identifying Cancer Driver Genes by Subnetwork Enrichment Analysis. PMID:33679866
SomatoSim: precision simulation of somatic single nucleotide variants. PMID:33676403
Comprehensive Profiling of Genomic and Transcriptomic Differences between Risk Groups of Lung Adenocarcinoma and Lung Squamous Cell Carcinoma. PMID:33672117
Mapping of Genomic Vulnerabilities in the Post-Translational Ubiquitination, SUMOylation and Neddylation Machinery in Breast Cancer. PMID:33671201
Detection of Somatic Mutations with ddPCR from Liquid Biopsy of Colorectal Cancer Patients. PMID:33669856
Knowledge-Guided "Community Network" Analysis Reveals the Functional Modules and Candidate Targets in Non-Small-Cell Lung Cancer. PMID:33669233
Current Knowledge on Genomic Profiling of Upper Tract Urothelial Carcinoma. PMID:33668859
Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers. PMID:33667223
AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity. PMID:33664996
Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors. PMID:33661099
Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells. PMID:33659038
Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains. PMID:33658503
Ablation of CRBN induces loss of type I collagen and SCH in mouse skin by fibroblast senescence via the p38 MAPK pathway. PMID:33658395
Development, maturation, and maintenance of human prostate inferred from somatic mutations. PMID:33657416
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics. PMID:33649320
A-to-I RNA Editing in Cancer: From Evaluating the Editing Level to Exploring the Editing Effects. PMID:33643923
NVP-BEZ235 or JAKi Treatment leads to decreased survival of examined GBM and BBC cells. PMID:33636591
A bladder cancer patient-derived xenograft displays aggressive growth dynamics in vivo and in organoid culture. PMID:33633154
Molecular profile of KRAS G12C-mutant colorectal and non-small-cell lung cancer. PMID:33632153
MEDALT: single-cell copy number lineage tracing enabling gene discovery. PMID:33622385
Sequential filtering for clinically relevant variants as a method for clinical interpretation of whole exome sequencing findings in glioma. PMID:33622343
Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A. PMID:33621062
Protein kinase C fusion proteins are paradoxically loss of function in cancer. PMID:33617877
A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS-Driven Lung Cancer. PMID:33608386
Identification of novel, clonally stable, somatic mutations targeting transcription factors PAX5 and NKX2-3, the epigenetic regulator LRIF1, and BRAF in a case of atypical B-cell chronic lymphocytic leukemia harboring a t(14;18)(q32;q21). PMID:33608382
Comparison of Open-access Databases for Clinical Variant Interpretation in Cancer: A Case Study of MDS/AML. PMID:33608312
Exploring the Differential Expression and Prognostic Significance of the COL11A1 Gene in Human Colorectal Carcinoma: An Integrated Bioinformatics Approach. PMID:33597969
BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1. PMID:33589814
Integrative Genomic Analyses of Patient-Matched Intracranial and Extracranial Metastases Reveal a Novel Brain-Specific Landscape of Genetic Variants in Driver Genes of Malignant Melanoma. PMID:33578810
Mechanism of forkhead transcription factors binding to a novel palindromic DNA site. PMID:33577686
AI-Driver: an ensemble method for identifying driver mutations in personal cancer genomes. PMID:33575629
Hematologic indices in individuals with pathogenic germline DICER1 variants. PMID:33570641
The Role of Necroptosis: Biological Relevance and Its Involvement in Cancer. PMID:33567618
Modular Reorganization of Signaling Networks during the Development of Colon Adenoma and Carcinoma. PMID:33562960
Making the Most of Complexity to Create Opportunities: Comprehensive Genomic Profiling and Molecular Tumor Board for Patients with Non-Small Cell Lung Cancer (NSCLC). PMID:33557047
Development and validation of a multigene variant profiling assay to guide targeted and immuno therapy selection in solid tumors. PMID:33556149
Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer. PMID:33553693
Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction. PMID:33540838
ADDRESS: A Database of Disease-associated Human Variants Incorporating Protein Structure and Folding Stabilities. PMID:33539887
Structural determinants of the IRF4/DNA homodimeric complex. PMID:33533913
Cutaneous and Mucosal Melanomas of Uncommon Sites: Where Do We Stand Now? PMID:33525348
Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation. PMID:33523931
Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity. PMID:33523837
Pathway-Based Drug-Repurposing Schemes in Cancer: The Role of Translational Bioinformatics. PMID:33520715
My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype. PMID:33514395
Support of BCP-ALL-cells by autologous bone marrow Th-cells involves induction of AID expression but not widespread AID off-target mutagenesis. PMID:33507341
Salicylates enhance CRM1 inhibitor antitumor activity by induction of S-phase arrest and impairment of DNA-damage repair. PMID:33507295
Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies. PMID:33504652
Analysis of Single Nucleotide Variants (SNVs) Induced by Exposure to PM10 in Lung Epithelial Cells Using Whole Genome Sequencing. PMID:33503946
The mutational repertoire of uterine sarcomas and carcinosarcomas in a Brazilian cohort: A preliminary study. PMID:33503190
Genomic Adaption and Mutational Patterns in a HaCaT Subline Resistant to Alkylating Agents and Ionizing Radiation. PMID:33498964
An improved assay for detection of theranostic gene translocations and MET exon 14 skipping in thoracic oncology. PMID:33495574
Genomic alterations predictive of response to radiosurgery in recurrent IDH-WT glioblastoma. PMID:33492602
MYBL2-Driven Transcriptional Programs Link Replication Stress and Error-prone DNA Repair With Genomic Instability in Lung Adenocarcinoma. PMID:33489883
An Efficient and Easy-to-Use Network-Based Integrative Method of Multi-Omics Data for Cancer Genes Discovery. PMID:33488678
The Genomic Landscape of Actinic Keratosis. PMID:33482222
Online informatics resources to facilitate cancer target and chemical probe discovery. PMID:33479663
Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24. PMID:33479206
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. PMID:33479123
Natural history, response to systemic therapy, and genomic landscape of plasmacytoid urothelial carcinoma. PMID:33473164
A platform for curated products from novel open reading frames prompts reinterpretation of disease variants. PMID:33468550
Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation. PMID:33453420
Rad18 mediates specific mutational signatures and shapes the genomic landscape of carcinogen-induced tumors in vivo. PMID:33447826
Diverse Taxonomies for Diverse Chemistries: Enhanced Representation of Natural Product Metabolism in UniProtKB. PMID:33445429
Biological roles of the B cell receptor-associated protein 31: Functional Implication in Cancer. PMID:33439410
Artificial Intelligence in Drug Discovery: A Comprehensive Review of Data-driven and Machine Learning Approaches. PMID:33437151
CTCF and EGR1 suppress breast cancer cell migration through transcriptional control of Nm23-H1. PMID:33436746
Structural insights into TSC complex assembly and GAP activity on Rheb. PMID:33436626
Cancer associated talin point mutations disorganise cell adhesion and migration. PMID:33431906
Use of signals of positive and negative selection to distinguish cancer genes and passenger genes. PMID:33427197
Biased Influences of Low Tumor Purity on Mutation Detection in Cancer. PMID:33425983
Therapy-induced Deletion in 11q23 Leading to Fusion of KMT2A With ARHGEF12 and Development of B Lineage Acute Lymphoplastic Leukemia in a Child Treated for Acute Myeloid Leukemia Caused by t(9;11)(p21;q23)/KMT2A-MLLT3. PMID:33419897
Noncoding RNAs Serve as the Deadliest Universal Regulators of all Cancers. PMID:33419895
scReQTL: an approach to correlate SNVs to gene expression from individual scRNA-seq datasets. PMID:33419390
Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling. PMID:33418509
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. PMID:33417831
SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets. PMID:33416848
MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1. PMID:33416496
Whole exome sequencing and establishment of an organoid culture of the carcinoma showing thymus-like differentiation (CASTLE) of the parotid gland. PMID:33415446
Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase Fusions. PMID:33414136
Chemical Decorations of "MARs" Residents in Orchestrating Eukaryotic Gene Regulation. PMID:33409278
Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer. PMID:33407715
Ferroptosis-Related Flavoproteins: Their Function and Stability. PMID:33406703
Mutation Frequency in Main Susceptibility Genes Among Patients With Head and Neck Paragangliomas. PMID:33391357
Discovery of acquired molecular signature on immune checkpoint inhibitors in paired tumor tissues. PMID:33389015
Network machine learning maps phytochemically rich "Hyperfoods" to fight COVID-19. PMID:33386081
The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity. PMID:33383924
Genomic and transcriptomic landscape of conjunctival melanoma. PMID:33383577
STAT3 and p53: Dual Target for Cancer Therapy. PMID:33371351
Alagille syndrome and risk for hepatocellular carcinoma: Need for increased surveillance in adults with mild liver phenotypes. PMID:33369123
m5C RNA Methylation Primarily Affects the ErbB and PI3K-Akt Signaling Pathways in Gastrointestinal Cancer. PMID:33365328
Beyond TNBC: Repositioning of Clofazimine Against a Broad Range of Wnt-Dependent Cancers. PMID:33363033
Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. PMID:33361816
Molecular dynamics approach to identification of new OGG1 cancer-associated somatic variants with impaired activity. PMID:33361155
Modeling molecular development of breast cancer in canine mammary tumors. PMID:33361113
Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites. PMID:33347579
Empagliflozin and Doxorubicin Synergistically Inhibit the Survival of Triple-Negative Breast Cancer Cells via Interfering with the mTOR Pathway and Inhibition of Calmodulin: In Vitro and Molecular Docking Studies. PMID:33344906
Selective Elimination of Osteosarcoma Cell Lines with Short Telomeres by Ataxia Telangiectasia and Rad3-Related Inhibitors. PMID:33344901
Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer Cells. PMID:33339169
Spliceosome Mutations in Uveal Melanoma. PMID:33333932
Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+ T Lymphocyte Signature. PMID:33329548
Oncology and Pharmacogenomics Insights in Polycystic Ovary Syndrome: An Integrative Analysis. PMID:33329391
Germline Variation and Somatic Alterations in Ewing Sarcoma. PMID:33326089
Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity. PMID:33318037
PD-1 blockade using pembrolizumab in adolescent and young adult patients with advanced bone and soft tissue sarcoma. PMID:33314769
ncDRMarker: a computational method for identifying non-coding RNA signatures of drug resistance based on heterogeneous network. PMID:33313140
Intron retention is a robust marker of intertumoral heterogeneity in pancreatic ductal adenocarcinoma. PMID:33311498
Overlapping variants in the blood, tissues and cell lines for patients with intracranial meningiomas are predominant in stem cell-related genes. PMID:33305042
Computational methods for detecting cancer hotspots. PMID:33304455
The conformational and mutational landscape of the ubiquitin-like marker for autophagosome formation in cancer. PMID:33302793
Prioritizing genes for systematic variant effect mapping. PMID:33300982
Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis. PMID:33296650
A validated lineage-derived somatic truth data set enables benchmarking in cancer genome analysis. PMID:33293579
Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression. PMID:33287884
Complete Response to PD-1 Inhibition in an Adolescent With Relapsed Clear Cell Adenocarcinoma of the Cervix Predicted by Neoepitope Burden and APOBEC Signature. PMID:33283136
Mastermind: A Comprehensive Genomic Association Search Engine for Empirical Evidence Curation and Genetic Variant Interpretation. PMID:33281875
PTEN and Other PtdIns(3,4,5)P3 Lipid Phosphatases in Breast Cancer. PMID:33276499
Common germline-somatic variant interactions in advanced urothelial cancer. PMID:33273457
Flype: Software for enabling personalized medicine. PMID:33270363
G Protein-Coupled receptors and heterotrimeric G proteins as cancer drivers. PMID:33270228
Differential Effects of Cancer-Associated Mutations Enriched in Helix H3 of PPARγ. PMID:33266062
Readfish enables targeted nanopore sequencing of gigabase-sized genomes. PMID:33257864
VarStack: a web tool for data retrieval to interpret somatic variants in cancer. PMID:33247936
Differences in gynecologic tumor development in Amhr2-Cre mice with KRASG12D or KRASG12V mutations. PMID:33244099
Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts. PMID:33237278
Possible A2E Mutagenic Effects on RPE Mitochondrial DNA from Innovative RNA-Seq Bioinformatics Pipeline. PMID:33233726
The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases. PMID:33233473
A Novel Germline c.1267T>A MEN1 Mutation in MEN1 Family-from Phenotype to Gene and Back. PMID:33233395
Identification of transcription factor co-regulators that drive prostate cancer progression. PMID:33230156
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy. PMID:33212010
Ex vivo culture of circulating tumour cells derived from non-small cell lung cancer. PMID:33209602
A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1. PMID:33208384
Technical and Methodological Aspects of Cell-Free Nucleic Acids Analyzes. PMID:33207777
Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma. PMID:33207206
Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy. PMID:33203880
Germline Variants That Affect Tumor Progression. PMID:33203571
Open Targets Platform: supporting systematic drug-target identification and prioritisation. PMID:33196847
RBP2GO: a comprehensive pan-species database on RNA-binding proteins, their interactions and functions. PMID:33196814
Overgrowth Syndromes-Evaluation, Diagnosis, and Management. PMID:33194904
Integration of Online Omics-Data Resources for Cancer Research. PMID:33193699
Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma. PMID:33193654
Plasma-derived extracellular vesicle analysis and deconvolution enable prediction and tracking of melanoma checkpoint blockade outcome. PMID:33188016
A conserved acetylation switch enables pharmacological control of tubby-like protein stability. PMID:33187986
Trop2: Jack of All Trades, Master of None. PMID:33187148
Quantitative Structure-Mutation-Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction. PMID:33183223
OncoVar: an integrated database and analysis platform for oncogenic driver variants in cancers. PMID:33179738
High-throughput proteomics of breast cancer interstitial fluid: identification of tumor subtype-specific serologically relevant biomarkers. PMID:33176066
Clinical and Genomic Characteristics of Adult Diffuse Midline Glioma. PMID:33171023
Comparative assessments of indel annotations in healthy and cancer genomes with next-generation sequencing data. PMID:33167946
The Mutational and Transcriptional Landscapes of Hepatocarcinogenesis in a Rat Model. PMID:33163943
How Elongator Acetylates tRNA Bases. PMID:33152999
Integrative Analysis of miRNAs Identifies Clinically Relevant Epithelial and Stromal Subtypes of Head and Neck Squamous Cell Carcinoma. PMID:33148669
Biocuration - mapping resources and needs. PMID:33145007
Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations. PMID:33144684
Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain. PMID:33143292
Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses. PMID:33142932
The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations. PMID:33139697
KinaseMD: kinase mutations and drug response database. PMID:33137204
Establishing a Framework for the Clinical Translation of Germline Findings in Precision Oncology. PMID:33134827
Noncoding RNA (ncRNA) Profile Association with Patient Outcome in Epithelial Ovarian Cancer Cases. PMID:33125686
Novel canine isocitrate dehydrogenase 1 mutation Y208C attenuates dimerization ability. PMID:33123262
Analysis of open chromatin regions in bladder cancer links β-catenin mutations and Wnt signaling with neuronal subtype of bladder cancer. PMID:33122695
RUNX3 methylation drives hypoxia-induced cell proliferation and antiapoptosis in early tumorigenesis. PMID:33116296
A systems genomics approach to uncover the molecular properties of cancer genes. PMID:33110144
Cancer therapy shapes the fitness landscape of clonal hematopoiesis. PMID:33106634
The autoinhibited state of MKK4: Phosphorylation, putative dimerization and R134W mutant studied by molecular dynamics simulations. PMID:33101607
The KDR (VEGFR-2) Genetic Polymorphism Q472H and c-KIT Polymorphism M541L Are Associated With More Aggressive Behaviour in Astrocytic Gliomas. PMID:33099473
Prediction of driver variants in the cancer genome via machine learning methodologies. PMID:33094325
Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis. PMID:33093207
NIMBus: a negative binomial regression based Integrative Method for mutation Burden Analysis. PMID:33092526
Keap1 inhibition sensitizes head and neck squamous cell carcinoma cells to ionizing radiation via impaired non-homologous end joining and induced autophagy. PMID:33087706
OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines. PMID:33084874
Validation and clinical application of a targeted next-generation sequencing gene panel for solid and hematologic malignancies. PMID:33083132
Cancer prognosis prediction using somatic point mutation and copy number variation data: a comparison of gene-level and pathway-based models. PMID:33081688
Large scale, robust, and accurate whole transcriptome profiling from clinical formalin-fixed paraffin-embedded samples. PMID:33077815
Development of synthetic lethality in cancer: molecular and cellular classification. PMID:33077733
Ultrafast and scalable variant annotation and prioritization with big functional genomics data. PMID:33060171
Clinical, FDG-PET and molecular markers of immune checkpoint inhibitor response in patients with metastatic Merkel cell carcinoma. PMID:33060145
Cancer-Associated Gain-of-Function Mutations Activate a SWI/SNF-Family Regulatory Hub. PMID:33058778
No association between <i>ECSIT</i> germline mutations and hemophagocytic lymphohistiocytosis in natural killer/T-cell lymphoma. PMID:33054138
Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. PMID:33053837
Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling. PMID:33046706
Anticancer drug synergy prediction in understudied tissues using transfer learning. PMID:33040150
KALRN mutations promote antitumor immunity and immunotherapy response in cancer. PMID:33037113
Dynamics of genomic and immune responses during primary immunotherapy resistance in mismatch repair-deficient tumors. PMID:33028646
The mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrence. PMID:33024263
RMVar: an updated database of functional variants involved in RNA modifications. PMID:33021671
Characteristics of mutational signatures of unknown etiology. PMID:33015626
Exploiting DNA repair defects in triple negative breast cancer to improve cell killing. PMID:32994807
CSVS, a crowdsourcing database of the Spanish population genetic variability. PMID:32990755
miRNASNP-v3: a comprehensive database for SNPs and disease-related variations in miRNAs and miRNA targets. PMID:32990748
The mutational signature profile of known and suspected human carcinogens in mice. PMID:32989322
Genomic Profiling Identified ERCC2 E606Q Mutation in Helicase Domain Respond to Platinum-Based Neoadjuvant Therapy in Urothelial Bladder Cancer. PMID:32984035
Favorable Immune Microenvironment in Patients with EGFR and MAPK Co-Mutations. PMID:32982525
Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor. PMID:32978388
Immunohistochemistry and Mutation Analysis of SDHx Genes in Carotid Paragangliomas. PMID:32971818
VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma. PMID:32963234
Targeting protein tyrosine kinase 6 in cancer. PMID:32956764
Limitations of Detecting Genetic Variants from the RNA Sequencing Data in Tissue and Fine-Needle Aspiration Samples. PMID:32948110
Scanning window analysis of non-coding regions within normal-tumor whole-genome sequence samples. PMID:32940334
Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer. PMID:32937789
Molecular Classification of Endometrial Stromal Sarcomas Using RNA Sequencing Defines Nosological and Prognostic Subgroups with Different Natural History. PMID:32933053
The clinical value and potential molecular mechanism of the downregulation of MAOA in hepatocellular carcinoma tissues. PMID:32931665
Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses. PMID:32929263
Single-cell transcriptomics in cancer: computational challenges and opportunities. PMID:32929226
PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition. PMID:32929011
Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas. PMID:32928922
Opportunities and Challenges for Analyzing Cancer Data at the Inter- and Intra-Institutional Levels. PMID:32923903
Durable Near-Complete Response to Olaparib Plus Temozolomide and Radiation in a Patient With ATM-Mutated Glioblastoma and MSH6-Deficient Lynch Syndrome. PMID:32923878
METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth. PMID:32923617
Growth rate alterations of human colorectal cancer cells by 157 gut bacteria. PMID:32915102
A pan-cancer assessment of alterations of the kinase domain of ULK1, an upstream regulator of autophagy. PMID:32913252
Cell-free DNA alterations in the AR enhancer and locus predict resistance to AR-directed therapy in patients with metastatic prostate cancer. PMID:32903952
Complex Mosaicism of Two Distinct Mutations in a Female Patient With KCNA2-Related Encephalopathy: A Case Report. PMID:32903602
RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling. PMID:32899426
Pre- and Post-Zygotic TP53 De Novo Mutations in SHH-Medulloblastoma. PMID:32899294
Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing. PMID:32887686
Genomics and Functional Genomics of Malignant Pleural Mesothelioma. PMID:32882916
The genomic landscape of Mongolian hepatocellular carcinoma. PMID:32873799
Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450. PMID:32872162
Matrix metalloproteinases in keratinocyte carcinomas. PMID:32869366
ARID1A protein expression is retained in ovarian endometriosis with ARID1A loss-of-function mutations: implication for the two-hit hypothesis. PMID:32868822
Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy. PMID:32863928
GLI1 activation is a key mechanism of erlotinib resistance in human non-small cell lung cancer. PMID:32863909
HybridSucc: A Hybrid-learning Architecture for General and Species-specific Succinylation Site Prediction. PMID:32861878
Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases. PMID:32855398
Non-BRAF Mutant Melanoma: Molecular Features and Therapeutical Implications. PMID:32850962
Identifying the Potential Mechanism of Action of SNPs Associated With Breast Cancer Susceptibility With GVITamIN. PMID:32850701
Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage. PMID:32846134
Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome. PMID:32841224
The Biological Significance of Multi-copy Regions and Their Impact on Variant Discovery. PMID:32827758
Dual Inhibition of Autophagy and PI3K/AKT/MTOR Pathway as a Therapeutic Strategy in Head and Neck Squamous Cell Carcinoma. PMID:32825725
Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications. PMID:32825279
Identification of MicroRNA-Related Tumorigenesis Variants and Genes in the Cancer Genome Atlas (TCGA) Data. PMID:32824926
From Patient Engagement to Precision Oncology: Leveraging Informatics to Advance Cancer Care. PMID:32823322
Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing. PMID:32822576
Leukemic stem cell phenotype is associated with mutational profile in acute myeloid leukemia. PMID:32811132
TMPRSS13 promotes cell survival, invasion, and resistance to drug-induced apoptosis in colorectal cancer. PMID:32807808
Analyses of DNA Methylation Involved in the Activation of Nuclear Karyopherin Alpha 2 Leading to Identify the Progression and Prognostic Significance Across Human Breast Cancer. PMID:32801900
Novel Somatic Genetic Variants as Predictors of Resistance to EGFR-Targeted Therapies in Metastatic Colorectal Cancer Patients. PMID:32796636
The Fetal Phenotype of Noonan Syndrome Caused by Severe, Cancer-Related PTPN11 Variants. PMID:32794475
Monitoring of Early Changes of Circulating Tumor DNA in the Plasma of Rectal Cancer Patients Receiving Neoadjuvant Concomitant Chemoradiotherapy: Evaluation for Prognosis and Prediction of Therapeutic Response. PMID:32793464
Expansion of germline RPS20 mutation phenotype to include Diamond-Blackfan anemia. PMID:32790018
Genomic Analysis of Localized High-Risk Prostate Cancer Circulating Tumor Cells at the Single-Cell Level. PMID:32784507
Mutation analysis and genomic imbalances of cells found in effusion fluids from patients with ovarian cancer. PMID:32782545
Detailed analysis of phenotypes and genotypes in megalencephaly-capillary malformation-polymicrogyria syndrome caused by somatic mosaicism of PIK3CA mutations. PMID:32778138
Limitations and challenges in protein stability prediction upon genome variations: towards future applications in precision medicine. PMID:32774791
Korean Genome Project: 1094 Korean personal genomes with clinical information. PMID:32766443
Molecular analysis of circulating tumor DNA from breast cancer patients before and after surgery and following adjuvant chemotherapy. PMID:32765873
Glycosaminoglycan-Protein Interactions: The First Draft of the Glycosaminoglycan Interactome. PMID:32757871
Non-Melanoma Skin Cancers: Biological and Clinical Features. PMID:32751327
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes. PMID:32747829
Mutational signature SBS8 predominantly arises due to late replication errors in cancer. PMID:32747711
Evaluation of the role of Nrf2/Keap1 pathway-associated novel mutations and gene expression on antioxidant status in patients with deep vein thrombosis. PMID:32742329
In Vivo Gene Therapy for Canine SCID-X1 Using Cocal-Pseudotyped Lentiviral Vector. PMID:32741228
Development and validation of Houston Methodist Variant Viewer version 3: updates to our application for interpretation of next-generation sequencing data. PMID:32734171
Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation. PMID:32733642
Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing. PMID:32724113
Protein-Protein Interactions Mediated by Intrinsically Disordered Protein Regions Are Enriched in Missense Mutations. PMID:32722039
PhosphoEffect: Prioritizing Variants On or Adjacent to Phosphorylation Sites through Their Effect on Kinase Recognition Motifs. PMID:32712465
Integration of Genomic Medicine in Pathology Resident Training. PMID:32696061
The Current State of Molecular Testing in the BRAF-Mutated Melanoma Landscape. PMID:32695793
The Clinical and Molecular Characterization of Gastric Cancer Patients in Qinghai-Tibetan Plateau. PMID:32695679
Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer. PMID:32693820
Tumor somatic mutations also existing as germline polymorphisms may help to identify functional SNPs from genome-wide association studies. PMID:32681635
Protein-Protein interactions uncover candidate 'core genes' within omnigenic disease networks. PMID:32678846
Prostate cancer biology & genomics. PMID:32676435
A novel cell-free single-molecule unique primer extension resequencing (cf-SUPER) technology for bladder cancer non-invasive detection in urine. PMID:32676405
Modeling and analysis of site-specific mutations in cancer identifies known plus putative novel hotspots and bias due to contextual sequences. PMID:32670506
Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System. PMID:32668202
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity. PMID:32667137
Disclosing the Interactome of Leukemogenic NUP98-HOXA9 and SET-NUP214 Fusion Proteins Using a Proteomic Approach. PMID:32664447
MutCombinator: identification of mutated peptides allowing combinatorial mutations using nucleotide-based graph search. PMID:32657416
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma. PMID:32649874
Human genes differ by their UV sensitivity estimated through analysis of UV-induced silent mutations in melanoma. PMID:32643855
Tumor mutational burden predicts survival in patients with low-grade gliomas expressing mutated IDH1. PMID:32642696
The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2. PMID:32636302
Identification of miRNA Master Regulators in Breast Cancer. PMID:32635183
NRAS mutant E132K identified in young-onset sporadic colorectal cancer and the canonical mutants G12D and Q61K affect distinct oncogenic phenotypes. PMID:32620824
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate. PMID:32619424
Secreted breast tumor interstitial fluid microRNAs and their target genes are associated with triple-negative breast cancer, tumor grade, and immune infiltration. PMID:32605588
High mutation burden of circulating cell-free DNA in early-stage breast cancer patients is associated with a poor relapse-free survival. PMID:32602248
Clinicopathologic characterization of malignant chondroblastoma: a neoplasm with locally aggressive behavior and metastatic potential that closely mimics chondroblastoma-like osteosarcoma. PMID:32601382
Genetic mutations and features of mantle cell lymphoma: a systematic review and meta-analysis. PMID:32598477
The Human Gene Mutation Database (HGMD®): optimizing its use in a clinical diagnostic or research setting. PMID:32596782
Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma. PMID:32589730
Coexisting TIF1γ-positive Primary Pulmonary Lymphoepithelioma-like Carcinoma and Anti-TIF1γ Antibody-positive Dermatomyositis. PMID:32581161
Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas. PMID:32580154
DNA damage repair pathway alterations in metastatic clear cell renal cell carcinoma and implications on systemic therapy. PMID:32571992
Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer. PMID:32571788
Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target. PMID:32560530
Activation and inhibition of nonsense-mediated mRNA decay control the abundance of alternative polyadenylation products. PMID:32542372
Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia. PMID:32541670
PDX1 DNA Methylation Distinguishes Two Subtypes of Pancreatic Neuroendocrine Neoplasms with a Different Prognosis. PMID:32512761
Beyond the Variants: Mutational Patterns in Next-Generation Sequencing Data for Cancer Precision Medicine. PMID:32509788
Compound Heterozygous Variants in Pediatric Cancers: A Systematic Review. PMID:32508881
Human gene and disease associations for clinical-genomics and precision medicine research. PMID:32508008
Inside-Out or Outside-In: Choosing the Right Model of Hepatocellular Cancer. PMID:32503685
Clinical acceleration of JAK2 p.V617F driven myeloproliferative disease due to a new uncommon homozygous MPL p.Y591D mutation. PMID:32499240
POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status. PMID:32497495
SNPnexus: a web server for functional annotation of human genome sequence variation (2020 update). PMID:32496546
FGFR4: A promising therapeutic target for breast cancer and other solid tumors. PMID:32492514
Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in lung cancer. PMID:32492203
Colibactin DNA-damage signature indicates mutational impact in colorectal cancer. PMID:32483361
Clonal lineage from normal endometrium to ovarian clear cell carcinoma through ovarian endometriosis. PMID:32473611
Crystal structure and interactions of the Tof1-Csm3 (Timeless-Tipin) fork protection complex. PMID:32469068
CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data. PMID:32466770
Genomic and Transcriptomic Characteristics According to Size of Papillary Thyroid Microcarcinoma. PMID:32466217
CVCDAP: an integrated platform for molecular and clinical analysis of cancer virtual cohorts. PMID:32449936
Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms. PMID:32442302
Molecular testing on bronchial washings for the diagnosis and predictive assessment of lung cancer. PMID:32441866
Identification of a Triple Drug Combination That Is Synergistically Cytotoxic for Triple-Negative Breast Cancer Cells Using a Novel Combination Discovery Approach. PMID:32441190
High polymerase ε expression associated with increased CD8+T cells improves survival in patients with non-small cell lung cancer. PMID:32433714
Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA). PMID:32430494
fcScan: a versatile tool to cluster combinations of sites using genomic coordinates. PMID:32429868
Dual Deep Sequencing Improves the Accuracy of Low-Frequency Somatic Mutation Detection in Cancer Gene Panel Testing. PMID:32429412
Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations. PMID:32427823
Homer1 is a Potential Biomarker for Prognosis in Human Colorectal Carcinoma, Possibly in Association with G3BP1 Signaling. PMID:32425603
The Evolution of Human Cancer Gene Duplications across Mammals. PMID:32421773
High Levels of Chromosomal Copy Number Alterations and TP53 Mutations Correlate with Poor Outcome in Younger Breast Cancer Patients. PMID:32416097
Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane. PMID:32414921
The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor-Positive Metastatic Breast Cancer. PMID:32404308
Frequency and spectrum of PIK3CA somatic mutations in breast cancer. PMID:32404150
Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma. PMID:32392801
Oviz-Bio: a web-based platform for interactive cancer genomics data visualization. PMID:32392343
Localized Hypertrophic Neuropathy as a Neoplastic Manifestation of KRAS-Mediated RASopathy. PMID:32388560
Characterization of long G4-rich enhancer-associated genomic regions engaging in a novel loop:loop 'G4 Kissing' interaction. PMID:32383760
Analysis of TP53 aflatoxin signature mutation in hepatocellular carcinomas from Guatemala: A cross-sectional study (2016-2017). PMID:32382660
Loss of Integrase Interactor 1 (INI1) Expression in a Subset of Differentiated Thyroid Cancer. PMID:32380731
HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases. PMID:32366477
Limited Proteolysis of Cyclooxygenase-2 Enhances Cell Proliferation. PMID:32366045
Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants. PMID:32365913
Exomes of Ductal Luminal Breast Cancer Patients from Southwest Colombia: Gene Mutational Profile and Related Expression Alterations. PMID:32365829
Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases. PMID:32358504
Tumor-Infiltrating CD8 T Cells Predict Clinical Breast Cancer Outcomes in Young Women. PMID:32357420
Estrogen receptor α (ERα)-binding super-enhancers drive key mediators that control uterine estrogen responses in mice. PMID:32354741
In Silico Analysis of a Highly Mutated Gene in Cancer Provides Insight into Abnormal mRNA Splicing: Splicing Factor 3B Subunit 1K700E Mutant. PMID:32354150
The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells. PMID:32353949
Erlotinib sensitivity of MAPK1p.D321N mutation in head and neck squamous cell carcinoma. PMID:32351709
Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction. PMID:32350270
EM-mosaic detects mosaic point mutations that contribute to congenital heart disease. PMID:32349777
Mining Drug-Target Associations in Cancer: Analysis of Gene Expression and Drug Activity Correlations. PMID:32344870
Allelic heterogeneity of Proteus syndrome. PMID:32327430
Neoadjuvant Nivolumab for Patients With Resectable Merkel Cell Carcinoma in the CheckMate 358 Trial. PMID:32324435
Targeted next generation sequencing identifies somatic mutations in a cohort of Egyptian breast cancer patients. PMID:32322420
Mechanisms and therapeutic implications of hypermutation in gliomas. PMID:32322066
High expression of CDCA7 predicts tumor progression and poor prognosis in human colorectal cancer. PMID:32319649
Identification of Pan-Cancer Prognostic Biomarkers Through Integration of Multi-Omics Data. PMID:32300588
The Ccr4-Not complex monitors the translating ribosome for codon optimality. PMID:32299921
Hierarchical discovery of large-scale and focal copy number alterations in low-coverage cancer genomes. PMID:32299346
QuaDMutNetEx: a method for detecting cancer driver genes with low mutation frequency. PMID:32293263
Capturing the primordial Kras mutation initiating urethane carcinogenesis. PMID:32286309
Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells. PMID:32283832
Emerging strategies to treat rare and intractable subtypes of melanoma. PMID:32274887
Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression. PMID:32270762
Molecular Trajectory of BRCA1 and BRCA2 Mutations. PMID:32269964
EGFR Polymorphism and Survival of NSCLC Patients Treated with TKIs: A Systematic Review and Meta-Analysis. PMID:32256580
Enhanced identification of significant regulators of gene expression. PMID:32252623
A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/- rats. PMID:32252027
Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions. PMID:32251294
pyCancerSig: subclassifying human cancer with comprehensive single nucleotide, structural and microsatellite mutational signature deconstruction from whole genome sequencing. PMID:32245405
KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment. PMID:32245394
SAMHD1 Functions and Human Diseases. PMID:32244340
Exome sequencing of familial high-grade serous ovarian carcinoma reveals heterogeneity for rare candidate susceptibility genes. PMID:32242007
Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors. PMID:32235770
Detection of Circulating Tumor DNA in Patients With Uterine Leiomyomas. PMID:32232185
Update on Fundamental Mechanisms of Thyroid Cancer. PMID:32231639
Generating high quality libraries for DIA MS with empirically corrected peptide predictions. PMID:32214105
The Frequency of Ras Mutations in Cancer. PMID:32209560
Infigratinib in upper tract urothelial carcinoma versus urothelial carcinoma of the bladder and its association with comprehensive genomic profiling and/or cell-free DNA results. PMID:32208524
Total mRNA Quantification in Single Cells: Sarcoma Cell Heterogeneity. PMID:32204559
Skewed X-Chromosome Inactivation and Compensatory Upregulation of Escape Genes Precludes Major Clinical Symptoms in a Female With a Large Xq Deletion. PMID:32194616
Downregulation of SFRP1 is a protumorigenic event in hepatoblastoma and correlates with beta-catenin mutations. PMID:32189106
Cryo-EM structure of SWI/SNF complex bound to a nucleosome. PMID:32188938
Exome sequencing identifies novel mutation signatures of UV radiation and trichostatin A in primary human keratinocytes. PMID:32188867
Pathogenesis and Clinical Management of Uterine Serous Carcinoma. PMID:32183290
Vitamin D3 Metabolites Demonstrate Prognostic Value in EGFR-Mutant Lung Adenocarcinoma and Can be Deployed to Oppose Acquired Therapeutic Resistance. PMID:32183160
The Atypical Protein Kinase C Small Molecule Inhibitor ζ-Stat, and Its Effects on Invasion Through Decreases in PKC-ζ Protein Expression. PMID:32175276
Identification of Biomarkers for Osteosarcoma Based on Integration Strategy. PMID:32173717
Second-hit APC mutation in a familial adamantinomatous craniopharyngioma. PMID:32170310
Molecular-Clinical Correlation in Pediatric Medulloblastoma: A Cohort Series Study of 52 Cases in Taiwan. PMID:32168907
Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis. PMID:32142681
Clinical response to pazopanib in a patient with endolymphatic sac tumor not associated with von Hippel-Lindau syndrome. PMID:32141326
Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription. PMID:32128251
Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives. PMID:32127560
Modeling clear cell renal cell carcinoma and therapeutic implications. PMID:32123314
CHG: A Systematically Integrated Database of Cancer Hallmark Genes. PMID:32117445
The Search for Molecular Markers in a Gene-Orphan Case Study of a Pediatric Spinal Cord Pilocytic Astrocytoma. PMID:32108034
Emerging roles of the αC-β4 loop in protein kinase structure, function, evolution, and disease. PMID:32101380
Dual-molecular barcode sequencing detects rare variants in tumor and cell free DNA in plasma. PMID:32099048
Genetic alterations of malignant pleural mesothelioma: association with tumor heterogeneity and overall survival. PMID:32083805
Phenotypic expansion of KMT2D-related disorder: Beyond Kabuki syndrome. PMID:32083401
Binding of the periplakin linker requires vimentin acidic residues D176 and E187. PMID:32081916
A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib. PMID:32076484
A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia. PMID:32074275
Neutrophil-like HL-60 cells expressing only GFP-tagged β-actin exhibit nearly normal motility. PMID:32072765
A Rapid Robust Method for Subgrouping Non-NF2 Meningiomas According to Genotype and Detection of Lower Levels of M2 Macrophages in AKT1 E17K Mutated Tumours. PMID:32070062
Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance. PMID:32060290
The Functional Consequences of Eukaryotic Topoisomerase 1 Interaction with G-Quadruplex DNA. PMID:32059547
An improved strategy for CRISPR/Cas9 gene knockout and subsequent wildtype and mutant gene rescue. PMID:32053639
BATCAVE: calling somatic mutations with a tumor- and site-specific prior. PMID:32051931
Comparative Molecular Life History of Spontaneous Canine and Human Gliomas. PMID:32049048
Targeted nanopore sequencing with Cas9-guided adapter ligation. PMID:32042167
Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins. PMID:32042025
'Omics Approaches to Explore the Breast Cancer Landscape. PMID:32039208
Integrative Network Analysis of Differentially Methylated and Expressed Genes for Biomarker Identification in Leukemia. PMID:32034170
A virtual molecular tumor board to improve efficiency and scalability of delivering precision oncology to physicians and their patients. PMID:32025647
Oncogene-dependent function of BRG1 in hepatocarcinogenesis. PMID:32019910
Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients. PMID:32000721
Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization. PMID:31988522
Low-frequency TP53 hotspot mutation contributes to chemoresistance through clonal expansion in acute myeloid leukemia. PMID:31988438
MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors. PMID:31965022
Assessment of Tumor Mutational Burden in Pediatric Tumors by Real-Life Whole-Exome Sequencing and In Silico Simulation of Targeted Gene Panels: How the Choice of Method Could Affect the Clinical Decision? PMID:31963488
Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations. PMID:31961934
Peptide-TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens. PMID:31932728
VISTA: Coming of age as a multi-lineage immune checkpoint. PMID:31930484
Tumoral and immune heterogeneity in an anti-PD-1-responsive glioblastoma: a case study. PMID:31907277
Molecular Profiling of Atypical Tenosynovial Giant Cell Tumors Reveals Novel Non-CSF1 Fusions. PMID:31906059
Therapeutic options for mucinous ovarian carcinoma. PMID:31902686
Functional annotation of de novo variants from healthy individuals. PMID:31896246
Characterization of JAK1 Pseudokinase Domain in Cytokine Signaling. PMID:31892268
Somatic mutations in intracranial arteriovenous malformations. PMID:31891627
ZDOG: zooming in on dominating genes with mutations in cancer pathways. PMID:31888434
Standardization of Somatic Variant Classifications in Solid and Haematological Tumours by a Two-Level Approach of Biological and Clinical Classes: An Initiative of the Belgian ComPerMed Expert Panel. PMID:31888289
A solid-phase transfection platform for arrayed CRISPR screens. PMID:31885201
The somatic mutation landscape of the human body. PMID:31874648
Comparison of somatic variant detection algorithms using Ion Torrent targeted deep sequencing data. PMID:31874647
A Review of Key Biological and Molecular Events Underpinning Transformation of Melanocytes to Primary and Metastatic Melanoma. PMID:31861163
Endometrial cancer and its cell lines. PMID:31848918
Somatic Mutation of PIK3CA (H1047R) Is a Common Driver Mutation Hotspot in Canine Mammary Tumors as Well as Human Breast Cancers. PMID:31842489
The human DEPhOsphorylation Database DEPOD: 2019 update. PMID:31836896
Deep whole-genome sequencing of 3 cancer cell lines on 2 sequencing platforms. PMID:31836783
CNVScope: Visually Exploring Copy Number Aberrations in Cancer Genomes. PMID:31832011
Characterization of organoid cultured human breast cancer. PMID:31829259
Alterations of the interactome of Bcl-2 proteins in breast cancer at the transcriptional, mutational and structural level. PMID:31825969
The most common RNF43 mutant G659Vfs*41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis. PMID:31811196
Using Transcriptional Signatures to Find Cancer Drivers with LURE. PMID:31797609
DNA Repair Footprint Uncovers Contribution of DNA Repair Mechanism to Mutational Signatures. PMID:31797602
Standard operating procedure for curation and clinical interpretation of variants in cancer. PMID:31779674
Dramatic increase in gene mutational burden after transformation of follicular lymphoma into TdT+ B-lymphoblastic leukemia/lymphoma. PMID:31776129
Vertical Pathway Inhibition Overcomes Adaptive Feedback Resistance to KRASG12C Inhibition. PMID:31776128
The role of noncoding mutations in blood cancers. PMID:31771951
Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. PMID:31759698
High content phenotypic screening identifies serotonin receptor modulators with selective activity upon breast cancer cell cycle and cytokine signaling pathways. PMID:31757681
Distinct functions of AKT isoforms in breast cancer: a comprehensive review. PMID:31752925
ChiTaRS 5.0: the comprehensive database of chimeric transcripts matched with druggable fusions and 3D chromatin maps. PMID:31747015
Functional characterization of MCAK/Kif2C cancer mutations using high-throughput microscopic analysis. PMID:31746663
TAZ functions as a tumor suppressor in multiple myeloma by downregulating MYC. PMID:31743393
Using Structural Analysis In Silico to Assess the Impact of Missense Variants in MEN1. PMID:31737856
DIANA-LncBase v3: indexing experimentally supported miRNA targets on non-coding transcripts. PMID:31732741
Alterations in ZnT1 expression and function lead to impaired intracellular zinc homeostasis in cancer. PMID:31728210
Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. PMID:31721781
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. PMID:31715132
Synthetic lethality as an engine for cancer drug target discovery. PMID:31712683
Identification of key regulators in prostate cancer from gene expression datasets of patients. PMID:31712650
Engaging chromatin: PRC2 structure meets function. PMID:31708574
CancerTracer: a curated database for intrapatient tumor heterogeneity. PMID:31701131
TYK2: An Upstream Kinase of STATs in Cancer. PMID:31694222
Prediction of impacts of mutations on protein structure and interactions: SDM, a statistical approach, and mCSM, using machine learning. PMID:31693276
Next-generation sequencing reveals unique combination of mutations in cis of CSF3R in atypical chronic myeloid leukemia. PMID:31692115
Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes. PMID:31687977
ACVR1 Function in Health and Disease. PMID:31683698
Unraveling allosteric landscapes of allosterome with ASD. PMID:31665428
Alazami syndrome: the first case of papillary thyroid carcinoma. PMID:31656314
MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription. PMID:31648989
Arteriovenous malformation associated with a HRAS mutation. PMID:31637524
LnCeVar: a comprehensive database of genomic variations that disturb ceRNA network regulation. PMID:31617563
Translational Application of Circulating DNA in Oncology: Review of the Last Decades Achievements. PMID:31615102
The combination of BET and PARP inhibitors is synergistic in models of cholangiocarcinoma. PMID:31605774
dbInDel: a database of enhancer-associated insertion and deletion variants by analysis of H3K27ac ChIP-Seq. PMID:31603498
CancerGeneNet: linking driver genes to cancer hallmarks. PMID:31598703
Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer. PMID:31596905
RNAIndel: discovering somatic coding indels from tumor RNA-Seq data. PMID:31593214
Debutant iOS app and gene-disease complexities in clinical genomics and precision medicine. PMID:31586224
BRAF Mutations and Dysregulation of the MAP Kinase Pathway Associated to Sinonasal Mucosal Melanomas. PMID:31581559
Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer. PMID:31562808
Improving our understanding of breast cancer tumorigenesis across ethnicities. PMID:31555678
Drivers of AR indifferent anti-androgen resistance in prostate cancer cells. PMID:31551480
Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer. PMID:31548343
Identification of targetable BRAF ΔN486_P490 variant by whole-genome sequencing leading to dabrafenib-induced remission of a BRAF-mutant pancreatic adenocarcinoma. PMID:31519698
Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes. PMID:31515279
regBase: whole genome base-wise aggregation and functional prediction for human non-coding regulatory variants. PMID:31511901
Mutated RAS: Targeting the "Untargetable" with T Cells. PMID:31511296
Alignment-free filtering for cfNA fusion fragments. PMID:31510681
pCRM1exportome: database of predicted CRM1-dependent Nuclear Export Signal (NES) motifs in cancer-related genes. PMID:31504173
SigsPack, a package for cancer mutational signatures. PMID:31477009
A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene. PMID:31469826
Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance. PMID:31467286
Venetoclax and hypomethylating agents in TP53-mutated acute myeloid leukaemia. PMID:31441045
Genomic and outcome analysis of adult T-cell lymphoblastic lymphoma. PMID:31413085
Atypical BRAF and NRAS Mutations in Mucosal Melanoma. PMID:31398831
TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma. PMID:31391125
A comparative study of curated contents by knowledge-based curation system in cancer clinical sequencing. PMID:31383922
Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection. PMID:31373491
Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome. PMID:31353912
A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencing. PMID:31349857
Circulating tumor DNA quantity is related to tumor volume and both predict survival in metastatic pancreatic ductal adenocarcinoma. PMID:31340061
Complement System in Cutaneous Squamous Cell Carcinoma. PMID:31331124
Proteogenomic Analysis of Protein Sequence Alterations in Breast Cancer Cells. PMID:31316139
Germline pathogenic variant in PIK3CA leading to symmetrical overgrowth with marked macrocephaly and mild global developmental delay. PMID:31290289
VIPdb, a genetic Variant Impact Predictor Database. PMID:31283070
HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods. PMID:31270435
Optimizing Genetic Workup in Pheochromocytoma and Paraganglioma by Integrating Diagnostic and Research Approaches. PMID:31212687
Evaluating the predictions of the protein stability change upon single amino acid substitutions for the FXN CAGI5 challenge. PMID:31209948
Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia. PMID:31209280
Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing. PMID:31175136
In vivo effects of chemotherapy on oncogenic pathways in colorectal cancer. PMID:31119819
Future Options of Molecular-Targeted Therapy in Small Cell Lung Cancer. PMID:31108964
CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule. PMID:31080802
DrugComb: an integrative cancer drug combination data portal. PMID:31066443
Are machine learning based methods suited to address complex biological problems? Lessons from CAGI-5 challenges. PMID:31066146
RB constrains lineage fidelity and multiple stages of tumour progression and metastasis. PMID:31043741
Whole exome sequencing reveals mutations in FAT1 tumor suppressor gene clinically impacting on peripheral T-cell lymphoma not otherwise specified. PMID:31028364
Chemoradiation induces epithelial-to-mesenchymal transition in esophageal adenocarcinoma. PMID:31018252
In silico learning of tumor evolution through mutational time series. PMID:31015295
Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer. PMID:31003445
BayesPI-BAR2: A New Python Package for Predicting Functional Non-coding Mutations in Cancer Patient Cohorts. PMID:31001324
Germline missense NF1 mutation in an elderly patient with a blastic plasmacytoid dendritic cell neoplasm. PMID:30977107
Reduced FRG1 expression promotes prostate cancer progression and affects prostate cancer cell migration and invasion. PMID:30975102
DNA Repair Gene Expression Adjusted by the PCNA Metagene Predicts Survival in Multiple Cancers. PMID:30965671
Augmented CD133 expression in distal margin correlates with poor prognosis in colorectal cancer. PMID:30950180
Genomic Common Data Model for Seamless Interoperation of Biomedical Data in Clinical Practice: Retrospective Study. PMID:30912749
A synonymous germline variant in a gene encoding a cell adhesion molecule is associated with cutaneous mast cell tumour development in Labrador and Golden Retrievers. PMID:30901340
Clonal analyses of refractory testicular germ cell tumors. PMID:30870501
Analysis of error profiles in deep next-generation sequencing data. PMID:30867008
Shared and unique genomic structural variants of different histological components within testicular germ cell tumours identified with mate pair sequencing. PMID:30837548
Tropomyosins: Potential Biomarkers for Urothelial Bladder Cancer. PMID:30836651
iPS-Cell Technology and the Problem of Genetic Instability-Can It Ever Be Safe for Clinical Use? PMID:30823421
Hormone therapy use and breast tissue DNA methylation: analysis of epigenome wide data from the normal breast study. PMID:30821641
An Integrative Data Mining and Omics-Based Translational Model for the Identification and Validation of Oncogenic Biomarkers of Pancreatic Cancer. PMID:30700038
Increased Mortality in SDHB but Not in SDHD Pathogenic Variant Carriers. PMID:30658386
Molecular Mechanisms of Leucine Zipper EF-Hand Containing Transmembrane Protein-1 Function in Health and Disease. PMID:30642051
The 26th annual Nucleic Acids Research database issue and Molecular Biology Database Collection. PMID:30626175
The Rio1 protein kinases/ATPases: conserved regulators of growth, division, and genomic stability. PMID:30515528
miRNA Mediated Noise Making of 3'UTR Mutations in Cancer. PMID:30424545
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website PubMed citations: 601.

601 articles citing: The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

New Drug Development and Clinical Trial Design by Applying Genomic Information Management. PMID:35893795
Mutant-Allele Tumor Heterogeneity, a Favorable Biomarker to Assess Intra-Tumor Heterogeneity, in Advanced Lung Adenocarcinoma. PMID:35847947
GraphChrom: A Novel Graph-Based Framework for Cancer Classification Using Chromosomal Rearrangement Endpoints. PMID:35804833
Histologically resolved multiomics enables precise molecular profiling of human intratumor heterogeneity. PMID:35776767
Measuring thermodynamic preferences to form non-native conformations in nucleic acids using ultraviolet melting. PMID:35671421
Estimating tumor mutational burden from RNA-sequencing without a matched-normal sample. PMID:35654823
Establishment and characterization of two novel patient-derived myxoid liposarcoma cell lines. PMID:35637403
A novel somatic mutation in GNAQ in a capillary malformation provides insight into molecular pathogenesis. PMID:35635655
Obesity-Associated Differentially Methylated Regions in Colon Cancer. PMID:35629083
MutaXome: A Novel Database for Identified Somatic Variations of In silico Analyzed Cancer Exome Datasets. PMID:35586731
Preliminary study on the role of the C5orf46 gene in renal cancer. PMID:35504177
DNA methylation profile of liver tissue in end-stage cholestatic liver disease. PMID:35473391
Recognition of a Novel Gene Signature for Human Glioblastoma. PMID:35456975
High-throughput functional evaluation of human cancer-associated mutations using base editors. PMID:35411116
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking. PMID:35410377
Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness. PMID:35365638
Ultrasensitive profiling of UV-induced mutations identifies thousands of subclinical facial tumors in tuberous sclerosis complex. PMID:35358092
Computational methods, databases and tools for synthetic lethality prediction. PMID:35352098
Translational advances in pancreatic ductal adenocarcinoma therapy. PMID:35352061
Role of Senescence in Tumorigenesis and Anticancer Therapy. PMID:35342397
Four drug metabolism-related subgroups of pancreatic adenocarcinoma in prognosis, immune infiltration, and gene mutation. PMID:35340619
Multifaceted Roles of the KEAP1-NRF2 System in Cancer and Inflammatory Disease Milieu. PMID:35326187
The Immunogenetics of Non-melanoma Skin Cancer. PMID:35286705
American Head and Neck Society Endocrine Surgery Section and International Thyroid Oncology Group consensus statement on mutational testing in thyroid cancer: Defining advanced thyroid cancer and its targeted treatment. PMID:35274388
Somatic and Germline Variant Calling from Next-Generation Sequencing Data. PMID:35230682
Syntenin Regulated by miR-216b Promotes Cancer Progression in Pancreatic Cancer. PMID:35155233
Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis. PMID:35149673
DriverFuse: An R package for analysis of next-generation sequencing datasets to identify cancer driver fusion genes. PMID:35113898
Extension of the Human Fibrinogen Database with Detailed Clinical Information-The αC-Connector Segment. PMID:35008554
Conditional prediction of consecutive tumor evolution using cancer progression models: What genotype comes next? PMID:34932572
Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics. PMID:34900668
Detection of gene mutations and gene-gene fusions in circulating cell-free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis. PMID:34875133
Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets. PMID:34855109
Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. PMID:34819355
[Expert Consensus on Tumor Mutational Burden for Immunotherapy in Lung Cancer]. PMID:34802204
Pancreatic Cancer-Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis. PMID:34797250
DCMP: database of cancer mutant protein domains. PMID:34791106
Individualized Proteogenomics Reveals the Mutational Landscape of Melanoma Patients in Response to Immunotherapy. PMID:34771574
Novel Dual PI3K/mTOR Inhibitor, Apitolisib (GDC-0980), Inhibits Growth and Induces Apoptosis in Human Glioblastoma Cells. PMID:34768941
Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells. PMID:34764293
Ovarian metastases of pancreatic adenocarcinoma: clinical presentation, role of surgery, and potential value of the mutational profile for the differential diagnosis with primary mucinous ovarian carcinoma. PMID:34721673
Mouse-INtraDuctal (MIND): an in vivo model for studying the underlying mechanisms of DCIS malignancy. PMID:34714554
Proteogenomics Reveals Perturbed Signaling Networks in Malignant Melanoma Cells Resistant to BRAF Inhibition. PMID:34673281
EZH2 inhibition confers PIK3CA-driven lung tumors enhanced sensitivity to PI3K inhibition. PMID:34655667
A Genome-Wide Profiling of Glioma Patients with an IDH1 Mutation Using the Catalogue of Somatic Mutations in Cancer Database. PMID:34503108
KRAS mutations in patients with colorectal cancer in Libya. PMID:34462653
Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction. PMID:34417497
Tunisian Maturity-Onset Diabetes of the Young: A Short Review and a New Molecular and Clinical Investigation. PMID:34393998
Using bioinformatics approaches to investigate driver genes and identify BCL7A as a prognostic gene in colorectal cancer. PMID:34306573
Liquid biopsy as an option for predictive testing and prognosis in patients with lung cancer. PMID:34217228
The structure-based cancer-related single amino acid variation prediction. PMID:34193921
Profiling of host genetic alterations and intra-tumor microbiomes in colorectal cancer. PMID:34188781
Germline RUNX1 variation and predisposition to childhood acute lymphoblastic leukemia. PMID:34166225
Identification of Somatic Gene Signatures in Circulating Cell-Free DNA Associated with Disease Progression in Metastatic Prostate Cancer by a Novel Machine Learning Platform. PMID:34157173
A Systems-Based Key Innovation-Driven Approach Infers Co-option of Jaw Developmental Programs During Cancer Progression. PMID:34150777
[Effect of stable overexpression of XAF1 gene on biological characteristics of ovarian cancer A2780 cells]. PMID:34134965
Cutaneous Melanoma Classification: The Importance of High-Throughput Genomic Technologies. PMID:34123788
Predicting anticancer hyperfoods with graph convolutional networks. PMID:34099048
2-kupl: mapping-free variant detection from DNA-seq data of matched samples. PMID:34090332
Translesion Synthesis Past 5-Formylcytosine-Mediated DNA-Peptide Cross-Links by hPolη Is Dependent on the Local DNA Sequence. PMID:34080848
The Unreasonable Effectiveness of Inverse Reinforcement Learning in Advancing Cancer Research. PMID:34055465
Small Molecules in the Treatment of Squamous Cell Carcinomas: Focus on Indirubins. PMID:33917267
Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases. PMID:33907576
The lncRNA GATA3-AS1/miR-495-3p/CENPU axis predicts poor prognosis of breast cancer via the PLK1 signaling pathway. PMID:33902008
A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency. PMID:33863366
Genomic, Transcriptomic, and Proteomic Profiling of Metastatic Breast Cancer. PMID:33782032
Significant impact of circulating tumour DNA mutations on survival in metastatic breast cancer patients. PMID:33762647
Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor. PMID:33750001
E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis. PMID:33627783
Understanding protein structural changes for oncogenic missense variants. PMID:33553733
Online informatics resources to facilitate cancer target and chemical probe discovery. PMID:33479663
Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation. PMID:33435458
An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression. PMID:33423164
Structural insights and evaluation of the potential impact of missense variants on the interactions of SLIT2 with ROBO1/4 in cancer progression. PMID:33318575
ncVarDB: a manually curated database for pathogenic non-coding variants and benign controls. PMID:33258967
Triangular Relationship between p53, Autophagy, and Chemotherapy Resistance. PMID:33256191
VarStack: a web tool for data retrieval to interpret somatic variants in cancer. PMID:33247936
Simultaneous Isolation of Circulating Nucleic Acids and EV-Associated Protein Biomarkers From Unprocessed Plasma Using an AC Electrokinetics-Based Platform. PMID:33224932
KRAS G12C mutations in Asia: a landscape analysis of 11,951 Chinese tumor samples. PMID:33209599
A Novel Six-Gene Signature for Prognosis Prediction in Ovarian Cancer. PMID:33193589
PRIMPOL ready, set, reprime! PMID:33179522
Structural Insight on Functional Regulation of Human MINERVA Protein. PMID:33142954
Metastatic Low-Grade Sarcoma with CARS-ALK Fusion Dramatically Responded to Multiple ALK Tyrosine Kinase Inhibitors: A Case Report with Comprehensive Genomic Analysis. PMID:32997436
YB-1 Knockdown Inhibits the Proliferation of Mesothelioma Cells through Multiple Mechanisms. PMID:32823952
Mathematical model of colorectal cancer initiation. PMID:32788368
Clinical responses to PD-1 inhibition and their molecular characterization in six patients with mismatch repair-deficient metastatic cancer of the digestive system. PMID:32776177
Pre-Treatment Mutational and Transcriptomic Landscape of Responding Metastatic Melanoma Patients to Anti-PD1 Immunotherapy. PMID:32708981
A six-attribute classification of genetic mosaicism. PMID:32661356
Data-driven network alignment. PMID:32614833
Cas9 activates the p53 pathway and selects for p53-inactivating mutations. PMID:32424350
Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST. PMID:32369930
Towards the routine use of in silico screenings for drug discovery using metabolic modelling. PMID:32369553
Separase-triggered apoptosis enforces minimal length of mitosis. PMID:32322059
Initiative for standardization of the format of the next-generation sequencing (NGS) results. PMID:32309567
Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer. PMID:32294438
A novel virtual barcode strategy for accurate panel-wide variant calling in circulating tumor DNA. PMID:32245364
The Inhibition of Wnt Restrain KRASG12V-Driven Metastasis in Non-Small-Cell Lung Cancer. PMID:32244355
Comparison of Fresh Frozen Tissue With Formalin-Fixed Paraffin-Embedded Tissue for Mutation Analysis Using a Multi-Gene Panel in Patients With Colorectal Cancer. PMID:32232001
STAT3 Mutation Is Associated with STAT3 Activation in CD30+ ALK- ALCL. PMID:32188095
STAT3 Mutation Is Associated with STAT3 Activation in CD30+ ALK- ALCL. PMID:32188095
ATM-Deficient Cancers Provide New Opportunities for Precision Oncology. PMID:32183301
Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver. PMID:32064334
Chlorpromazine binding to the PAS domains uncovers the effect of ligand modulation on EAG channel activity. PMID:32047112
'Omics Approaches to Explore the Breast Cancer Landscape. PMID:32039208
Cyclin F is involved in response to cisplatin treatment in melanoma cell lines. PMID:32020229
Somatic genetic aberrations in gallbladder cancer: comparison between Chinese and US patients. PMID:31929987
Identification of Two Kinase Inhibitors with Synergistic Toxicity with Low-Dose Hydrogen Peroxide in Colorectal Cancer Cells in vitro. PMID:31906582
A Novel, Heterozygous Three Base-Pair Deletion in CARD11 Results in B Cell Expansion with NF-κB and T Cell Anergy Disease. PMID:31897776
Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas. PMID:31889115
Identification of Common and Subtype-Specific Mutated Sub-Pathways for a Cancer. PMID:31850075
BRAF Mutations Occur Infrequently in Ovarian Cancer but Suggest Responsiveness to BRAF and MEK Inhibition. PMID:31799491
Cancer Is Associated with Alterations in the Three-Dimensional Organization of the Genome. PMID:31783642
Gene mutation profiling in Chinese colorectal cancer patients and its association with clinicopathological characteristics and prognosis. PMID:31782259
Targeting the JAK/STAT Pathway in T Cell Lymphoproliferative Disorders. PMID:31741284
PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9. PMID:31652979
Debutant iOS app and gene-disease complexities in clinical genomics and precision medicine. PMID:31586224
XMAn v2-a database of Homo sapiens mutated peptides. PMID:31539018
Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations. PMID:31484939
C3: Consensus Cancer Driver Gene Caller. PMID:31465854
Differentiated Thyroid Carcinoma in Pediatric Age: Genetic and Clinical Scenario. PMID:31456750
PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia. PMID:31381561
Every which way? On predicting tumor evolution using cancer progression models. PMID:31374072
Clinical Evaluation of IntelliPlex™ KRAS G12/13 Mutation Kit for Detection of KRAS Mutations in Codon 12 and 13: A Novel Multiplex Approach. PMID:31347028
Distinct clinical and biological implications of CUX1 in myeloid neoplasms. PMID:31320321
Phenotypic characterization of the novel, non-hotspot oncogenic KRAS mutants E31D and E63K. PMID:31289513
Role of keratan sulfate expression in human pancreatic cancer malignancy. PMID:31273306
"Somatic" and "pathogenic" - is the classification strategy applicable in times of large-scale sequencing? PMID:31273095
FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding. PMID:31262713
KRAS Exon 3 and PTEN Exon 7 Mutations in Small-cell Lung Cancer. PMID:31209806
A pan-cancer analysis of synonymous mutations. PMID:31189880
Computational Screening and Analysis of Lung Cancer Related Non-Synonymous Single Nucleotide Polymorphisms on the Human Kirsten Rat Sarcoma Gene. PMID:31117243
Identification of TP53RK-Binding Protein (TPRKB) Dependency in TP53-Deficient Cancers. PMID:31110156
Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets. PMID:31105872
NeoMutate: an ensemble machine learning framework for the prediction of somatic mutations in cancer. PMID:31096972
Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts. PMID:31053105
Genetics of testicular germ cell tumors. PMID:31045925
Molecular Profiling of Hard-to-Treat Childhood and Adolescent Cancers. PMID:31026031
In silico learning of tumor evolution through mutational time series. PMID:31015295
Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study. PMID:31011206
Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan. PMID:30992375
Tensor clustering with algebraic constraints gives interpretable groups of crosstalk mechanisms in breast cancer. PMID:30958184
Mad1 destabilizes p53 by preventing PML from sequestering MDM2. PMID:30948704
A Model Information Management Plan for Molecular Pathology Sequence Data Using Standards: From Sequencer to Electronic Health Record. PMID:30797065
Establishment and characterization of a novel dedifferentiated chondrosarcoma cell line, NCC-dCS1-C1. PMID:30737713
A cancer-associated point mutation disables the steric gate of human PrimPol. PMID:30718533
Redox inhibition of protein phosphatase PP2A: Potential implications in oncogenesis and its progression. PMID:30686777
Physical plasma-treated saline promotes an immunogenic phenotype in CT26 colon cancer cells in vitro and in vivo. PMID:30679720
A CATH domain functional family based approach to identify putative cancer driver genes and driver mutations. PMID:30670742
The Modulatory Role of MicroRNA-873 in the Progression of KRAS-Driven Cancers. PMID:30654191
Clinical significance of multiple gene detection with a 22-gene panel in formalin-fixed paraffin-embedded specimens of 207 colorectal cancer patients. PMID:30612269
Somatic genetic alterations in synchronous and metachronous low-grade serous tumours and high-grade carcinomas of the adnexa. PMID:30565721
Long-peptide vaccination with driver gene mutations in p53 and Kras induces cancer mutation-specific effector as well as regulatory T cell responses. PMID:30524892
FAM129B promoted tumor invasion and proliferation via facilitating the phosphorylation of FAK signaling and associated with adverse clinical outcome of non-small cell lung cancer patients. PMID:30498362
SeqVItA: Sequence Variant Identification and Annotation Platform for Next Generation Sequencing Data. PMID:30487811
COSMIC: the Catalogue Of Somatic Mutations In Cancer. PMID:30371878
Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase. PMID:30261690
Next-generation sequencing and personalized genomic medicine in hepatobiliary malignancies. PMID:30191018
Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma. PMID:30182330
Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer. PMID:30146241
COL1A1: A potential therapeutic target for colorectal cancer expressing wild-type or mutant KRAS. PMID:30132520
From homogeneous to heterogeneous network alignment via colored graphlets. PMID:30131590
The expression of genes contributing to pancreatic adenocarcinoma progression is influenced by the respective environment. PMID:30108682
Genetic and transcriptional evolution alters cancer cell line drug response. PMID:30089904
CDKN2A Germline Rare Coding Variants and Risk of Pancreatic Cancer in Minority Populations. PMID:30038052
Exceptional Chemotherapy Response in Metastatic Colorectal Cancer Associated With Hyper-Indel-Hypermutated Cancer Genome and Comutation of POLD1 and MLH1. PMID:30009279
Oncolytic Immunotherapy for Bladder Cancer Using Coxsackie A21 Virus. PMID:29989024
Mutations of p53 decrease sensitivity to the anthracycline treatments in bladder cancer cells. PMID:29983877
Evaluation of CHK1 activation in vulvar squamous cell carcinoma and its potential as a therapeutic target in vitro. PMID:29963769
Intracranial Germ Cell Tumor in the Molecular Era. PMID:29742886
Elevated serum RAS p21 is an independent prognostic factor in metastatic breast cancer. PMID:29739347
Cancer driver mutation prediction through Bayesian integration of multi-omic data. PMID:29738578
Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer. PMID:29731394
ENTPRISE-X: Predicting disease-associated frameshift and nonsense mutations. PMID:29723276
Inherent flexibility of CLIC6 revealed by crystallographic and solution studies. PMID:29720717
IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma. PMID:29669935
Exosome-Mediated Transfer of Cancer Cell Resistance to Antiestrogen Drugs. PMID:29617321
Whole-exome sequencing identifies germline mutation in TP53 and ATRX in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma. PMID:29602769
Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer. PMID:29535384
The Immunome of Colon Cancer: Functional In Silico Analysis of Antigenic Proteins Deduced from IgG Microarray Profiling. PMID:29505855
ATLANTIS - Attractor Landscape Analysis Toolbox for Cell Fate Discovery and Reprogramming. PMID:29476134
Genome sequencing identifies somatic BRAF duplication c.1794_1796dupTAC;p.Thr599dup in pediatric patient with low-grade ganglioglioma. PMID:29434027
CoVaCS: a consensus variant calling system. PMID:29402227
Multicenter validation of cancer gene panel-based next-generation sequencing for translational research and molecular diagnostics. PMID:29374318
Somatic evolutionary timings of driver mutations. PMID:29347918
Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family. PMID:29309642
Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis. PMID:29299135
Preclinical and clinical development of neoantigen vaccines. PMID:29253113
Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis. PMID:29237412
KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation. PMID:29235861
STAT5BN642H is a driver mutation for T cell neoplasia. PMID:29200404
A network diffusion approach to inferring sample-specific function reveals functional changes associated with breast cancer. PMID:29190299
Identification of large rearrangements in cancer genomes with barcode linked reads. PMID:29186506
High-throughput full-length single-cell mRNA-seq of rare cells. PMID:29186152
Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer. PMID:29161592
Excluding Lynch syndrome in a female patient with metachronous DNA mismatch repair deficient colon- and ovarian cancer. PMID:29124495
Prevalence and detection of low-allele-fraction variants in clinical cancer samples. PMID:29123093
BRAF peptide vaccine facilitates therapy of murine BRAF-mutant melanoma. PMID:29094184
Characterisation of the changing genomic landscape of metastatic melanoma using cell free DNA. PMID:29075515
Lnc2Meth: a manually curated database of regulatory relationships between long non-coding RNAs and DNA methylation associated with human disease. PMID:29069510
Neurotensin receptor type 2 protects B-cell chronic lymphocytic leukemia cells from apoptosis. PMID:29059151
A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteome. PMID:29038160
Optimal detection of clinically relevant mutations in colorectal carcinoma: sample pooling overcomes intra-tumoral heterogeneity. PMID:29027537
Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors. PMID:28982154
SWI/SNF Infobase-An exclusive information portal for SWI/SNF remodeling complex subunits. PMID:28961249
Next-Generation Sequencing in the Clinical Setting Clarifies Patient Characteristics and Potential Actionability. PMID:28939679
Viral based vaccine TG4010 induces broadening of specific immune response and improves outcome in advanced NSCLC. PMID:28923084
Hallmarks of glioblastoma: a systematic review. PMID:28912963
Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures. PMID:28912153
Prognostic Significance of Circulating RET M918T Mutated Tumor DNA in Patients With Advanced Medullary Thyroid Carcinoma. PMID:28911154
miR-300 regulates cellular radiosensitivity through targeting p53 and apaf1 in human lung cancer cells. PMID:28895780
A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2. PMID:28874847
Mitochondrial mutations in human cancer: Curation of translation. PMID:28873329
The neoepitope landscape in pediatric cancers. PMID:28854978
BRAF mutation as a novel driver of eosinophilic cystitis. PMID:28829677
The Case for Laboratory Developed Procedures: Quality and Positive Impact on Patient Care. PMID:28815200
Comprehensive Genomic Profiling of Metastatic Squamous Cell Carcinoma of the Anal Canal. PMID:28784613
p53 loss does not permit escape from BrafV600E-induced senescence in a mouse model of lung cancer. PMID:28745322
A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers. PMID:28733453
Genomic abnormalities in invasive endocervical adenocarcinoma correlate with pattern of invasion: biologic and clinical implications. PMID:28731050
CrossCheck: an open-source web tool for high-throughput screen data analysis. PMID:28724888
Deconstruction of the Ras switching cycle through saturation mutagenesis. PMID:28686159
The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer. PMID:28684677
Targeting mitotic pathways for endocrine-related cancer therapeutics. PMID:28615236
CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism. PMID:28533324
Targeted sequencing of tonsillar and base of tongue cancer and human papillomavirus positive unknown primary of the head and neck reveals prognostic effects of mutated FGFR3. PMID:28525363
Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia. PMID:28505595
WDR23 regulates NRF2 independently of KEAP1. PMID:28453520
KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer. PMID:28452926
K-RAS and N-RAS mutations in testicular germ cell tumors. PMID:28426398
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. PMID:28420421
Genomic and proteomic characterization of ARID1A chromatin remodeller in ampullary tumors. PMID:28401006
Pysim-sv: a package for simulating structural variation data with GC-biases. PMID:28361688
Orchestrating differential data access for translational research: a pilot implementation. PMID:28330491
Tobacco habituated and non-habituated subjects exhibit different mutational spectrums in head and neck squamous cell carcinoma. PMID:28324520
Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation. PMID:28317937
Role of Structural Bioinformatics in Drug Discovery by Computational SNP Analysis: Analyzing Variation at the Protein Level. PMID:28302551
Precision medicine driven by cancer systems biology. PMID:28265786
The marine triterpene glycoside frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells. PMID:28143426
Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma. PMID:28099935
IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study. PMID:27997540
HOP expression is regulated by p53 and RAS and characteristic of a cancer gene signature. PMID:27987076
A cloud-based workflow to quantify transcript-expression levels in public cancer compendia. PMID:27982081
Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers. PMID:27974415
COSMIC: somatic cancer genetics at high-resolution. PMID:27899578
The Chromatin Assembly Factor Complex 1 (CAF1) and 5-Azacytidine (5-AzaC) Affect Cell Motility in Src-transformed Human Epithelial Cells. PMID:27872192
A missense methionine mutation augments catalytic activity but reduces thermal stability in two protein tyrosine phosphatases. PMID:27816449
A map of mobile DNA insertions in the NCI-60 human cancer cell panel. PMID:27807467
Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours. PMID:27798604
KinView: a visual comparative sequence analysis tool for integrated kinome research. PMID:27731453
PSSV: a novel pattern-based probabilistic approach for somatic structural variation identification. PMID:27659451
Cancer Stem Cells in Squamous Cell Carcinoma. PMID:27638386
Next-Generation Sequencing in Intellectual Disability. PMID:27617123
[Actinic keratoses]. PMID:27613022
KRAS Mutation in Small Cell Lung Carcinoma and Extrapulmonary Small Cell Cancer. PMID:27606136
Molecular mechanism leading to SAHA-induced autophagy in tumor cells: evidence for a p53-dependent pathway. PMID:27601937
Testicular germ cell tumor genomics. PMID:27584029
RalA is overactivated in medulloblastoma. PMID:27566179
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. PMID:27561929
Elucidating Genomic Characteristics of Lung Cancer Progression from In Situ to Invasive Adenocarcinoma. PMID:27545006
Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations. PMID:27499925
The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts. PMID:27494403
Establishing a baseline for literature mining human genetic variants and their relationships to disease cohorts. PMID:27454860
Aberrant expression and functions of protocadherins in human malignant tumors. PMID:27449047
A first-in-human phase I study to evaluate the MEK1/2 inhibitor, cobimetinib, administered daily in patients with advanced solid tumors. PMID:27424159
Tracking Cancer Genetic Evolution using OncoTrack. PMID:27412732
TMC-SNPdb: an Indian germline variant database derived from whole exome sequences. PMID:27402678
JAK-STAT signaling in cancer: From cytokines to non-coding genome. PMID:27349799
Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer. PMID:27329137
To live or let die - complexity within the E2F1 pathway. PMID:27308406
Genome-wide characterization of human L1 antisense promoter-driven transcripts. PMID:27301971
Significance of duon mutations in cancer genomes. PMID:27272679
Metabolic rewiring in melanoma. PMID:27270434
In Hyperthermia Increased ERK and WNT Signaling Suppress Colorectal Cancer Cell Growth. PMID:27187477
Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer. PMID:27182968
Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism. PMID:27159400
Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses. PMID:27152965
A common founding clone with TP53 and PTEN mutations gives rise to a concurrent germ cell tumor and acute megakaryoblastic leukemia. PMID:27148581
Discovering and understanding oncogenic gene fusions through data intensive computational approaches. PMID:27105842
Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas. PMID:27096031
Molecular Heterogeneity of Ewing Sarcoma as Detected by Ion Torrent Sequencing. PMID:27077911
The degree of intratumor mutational heterogeneity varies by primary tumor sub-site. PMID:27034009
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors. PMID:27022756
ENTPRISE: An Algorithm for Predicting Human Disease-Associated Amino Acid Substitutions from Sequence Entropy and Predicted Protein Structures. PMID:26982818
Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis. PMID:26973251
Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination. PMID:26965143
Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers. PMID:26917980
Endogenous network states predict gain or loss of functions for genetic mutations in hepatocellular carcinoma. PMID:26911487
Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy. PMID:26887045
Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease. PMID:26847028
The kinome 'at large' in cancer. PMID:26822576
Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases. PMID:26797410
EGFR phosphorylates FAM129B to promote Ras activation. PMID:26721396
Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity. PMID:26701849
Prevalence of Titin Truncating Variants in General Population. PMID:26701604
Age-related mutations and chronic myelomonocytic leukemia. PMID:26648538
Liquid biopsy for detection of actionable oncogenic mutations in human cancers and electric field induced release and measurement liquid biopsy (eLB). PMID:26645892
Overexpression of centromere protein K (CENPK) in ovarian cancer is correlated with poor patient survival and associated with predictive and prognostic relevance. PMID:26587348
The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. PMID:26573295
Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients. PMID:26508446
Thyroid C-Cell Biology and Oncogenic Transformation. PMID:26494382
Big Data: the challenge for small research groups in the era of cancer genomics. PMID:26492224
Oncogenomic portals for the visualization and analysis of genome-wide cancer data. PMID:26484415
Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092. PMID:26469692
Negative regulation of RNA-binding protein HuR by tumor-suppressor ECRG2. PMID:26434587
Genetic Testing and Tissue Banking for Personalized Oncology: Analytical and Institutional Factors. PMID:26433552
TumorTracer: a method to identify the tissue of origin from the somatic mutations of a tumor specimen. PMID:26429708
Hyperplasia in glands with hormone excess. PMID:26407873
Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma. PMID:26384810
An ensemble approach to accurately detect somatic mutations using SomaticSeq. PMID:26381235
Prognostic value of the KRAS G12V mutation in 841 surgically resected Caucasian lung adenocarcinoma cases. PMID:26372703
Automatically Detecting Failures in Natural Language Processing Tools for Online Community Text. PMID:26323337
Global Cell Proteome Profiling, Phospho-signaling and Quantitative Proteomics for Identification of New Biomarkers in Acute Myeloid Leukemia Patients. PMID:26306748
Identification of Genetic Mutations in Human Lung Cancer by Targeted Sequencing. PMID:26244006
Contralateral breast cancer can represent a metastatic spread of the first primary tumor: determination of clonal relationship between contralateral breast cancers using next-generation whole genome sequencing. PMID:26242876
N-glycosylation controls the function of junctional adhesion molecule-A. PMID:26224316
Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomas. PMID:26221190
Towards pathway-centric cancer therapies via pharmacogenomic profiling analysis of ERK signalling pathway. PMID:26220863
Precise Classification of Cervical Carcinomas Combined with Somatic Mutation Profiling Contributes to Predicting Disease Outcome. PMID:26197069
In vitro prediction of the efficacy of molecularly targeted cancer therapy by Raman spectral imaging. PMID:26168967
Genetic mutations in human rectal cancers detected by targeted sequencing. PMID:26134512
Only one health, and so many omics. PMID:26101467
Computational Pathology: A Path Ahead. PMID:26098131
The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas. PMID:26085527
Association of CCND1 overexpression with KRAS and PTEN alterations in specific subtypes of non-small cell lung carcinoma and its influence on patients' outcome. PMID:26055143
The homogeneous mutation status of a 22 gene panel justifies the use of serial sections of colorectal cancer tissue for external quality assessment. PMID:26047774
A comprehensive analysis of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) loss in colorectal cancer. PMID:25986931
PDGFRA-mutant syndrome. PMID:25975287
Fast and scalable inference of multi-sample cancer lineages. PMID:25944252
Cell-lineage heterogeneity and driver mutation recurrence in pre-invasive breast neoplasia. PMID:25918554
Treating medullary thyroid cancer in the age of targeted therapy. PMID:25908961
EGFR Mutant Structural Database: computationally predicted 3D structures and the corresponding binding free energies with gefitinib and erlotinib. PMID:25886721
Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours. PMID:25884485
A decision support framework for genomically informed investigational cancer therapy. PMID:25863335
GeneMed: An Informatics Hub for the Coordination of Next-Generation Sequencing Studies that Support Precision Oncology Clinical Trials. PMID:25861217
PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia. PMID:25855603
Protein domain-level landscape of cancer-type-specific somatic mutations. PMID:25794154
Next-generation sequencing reveals clinically actionable molecular markers in myeloid sarcoma. PMID:25787914
Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection. PMID:25786870
Rapid detection of genetic mutations in individual breast cancer patients by next-generation DNA sequencing. PMID:25757876
Recurrent SKIL-activating rearrangements in ETS-negative prostate cancer. PMID:25749039
Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage. PMID:25744535
Comparative analysis of KRAS codon 12, 13, 18, 61, and 117 mutations using human MCF10A isogenic cell lines. PMID:25705018
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. PMID:25629630
Clinical actionability enhanced through deep targeted sequencing of solid tumors. PMID:25626406
Functional consequence of the MET-T1010I polymorphism in breast cancer. PMID:25605252
A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation. PMID:25572802
Complex-based analysis of dysregulated cellular processes in cancer. PMID:25521701
Elderly former smoker with HRAS mutant non-small-cell lung cancer. PMID:25521407
Immunohistochemical detection of the BRAF V600E mutant protein in colorectal neoplasms. PMID:25517872
The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer. PMID:25491778
A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis. PMID:25486196
Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer. PMID:25480945
FISH molecular testing in cytological preparations from solid tumors. PMID:25478010
Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment. PMID:25477533
Association between specific KRAS mutations and the clinicopathological characteristics of colorectal tumors. PMID:25469291
Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin type. PMID:25466284
Rescuing dicer defects via inhibition of an anti-dicing nuclease. PMID:25457613
Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer. PMID:25444907
HotSpotter: efficient visualization of driver mutations. PMID:25435088
Radiomics and circulating tumor cells: personalized care in hepatocellular carcinoma? PMID:25430530
Comprehensive characterization of the genomic alterations in human gastric cancer. PMID:25422082
Insights into genetic and epigenetic determinants with impact on vitamin d signaling and cancer association studies: the case of thyroid cancer. PMID:25414832
A computational model incorporating neural stem cell dynamics reproduces glioma incidence across the lifespan in the human population. PMID:25409511
Structure-based predictions broadly link transcription factor mutations to gene expression changes in cancers. PMID:25378323
Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status. PMID:25375092
The axis of progression of disease. PMID:25374458
COSMIC: exploring the world's knowledge of somatic mutations in human cancer. PMID:25355519
Pharmacological profiling of kinase dependency in cell lines across triple-negative breast cancer subtypes. PMID:25344583
Noninvasive saliva-based EGFR gene mutation detection in patients with lung cancer. PMID:25317990
Dysregulated serum response factor triggers formation of hepatocellular carcinoma. PMID:25266280
The clinical response to vemurafenib in a patient with a rare BRAFV600DK601del mutation-positive melanoma. PMID:25265970
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. PMID:25263562
A new class of cancer-associated PTEN mutations defined by membrane translocation defects. PMID:25263454
Changes of KRAS Exon 2 Codon 12/13 Mutation Status in Recurrent Colorectal Cancer. PMID:25248721
Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance. PMID:25247188
Hepatocellular carcinoma: can circulating tumor cells and radiogenomics deliver personalized care? PMID:25238287
Single nucleotide variations: biological impact and theoretical interpretation. PMID:25234433
PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data. PMID:25192370
Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. PMID:25130491
Human somatic cell mutagenesis creates genetically tractable sarcomas. PMID:25129143
Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors. PMID:25127139
Targeting BRAF mutant metastatic colorectal cancer: clinical implications and emerging therapeutic strategies. PMID:25119972
Different mutational characteristics of TSG in cell lines and surgical specimens. PMID:25119593
Available resources and challenges for the clinical annotation of somatic variations. PMID:25111663
Lean Big Data integration in systems biology and systems pharmacology. PMID:25109570
The dynamic range of circulating tumor DNA in metastatic breast cancer. PMID:25107527
BRCA1 pathway function in basal-like breast cancer cells. PMID:25092866
Sporadic early-onset colorectal cancer is a specific sub-type of cancer: a morphological, molecular and genetics study. PMID:25083765
Frequent KIT mutations in human gastrointestinal stromal tumors. PMID:25080996
Putative cis-regulatory drivers in colorectal cancer. PMID:25079323
Genetic mutation analysis of human gastric adenocarcinomas using ion torrent sequencing platform. PMID:25025766
Mutational profiling of the RAS, PI3K, MET and b-catenin pathways in cancer of unknown primary: a retrospective study of the Hellenic Cooperative Oncology Group. PMID:24997156
Viral oncogene expression in the stem/progenitor cell compartment of the mouse intestine induces adenomatous polyps. PMID:24994749
A unified nomenclature and amino acid numbering for human PTEN. PMID:24985344
An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma. PMID:24969085
'Druggable' alterations detected by Ion Torrent in metastatic colorectal cancer patients. PMID:24932229
Targeted resequencing of the microRNAome and 3'UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer. PMID:24909162
FIGG: simulating populations of whole genome sequences for heterogeneous data analyses. PMID:24885193
Exome sequencing reveals a potential mutational trajectory and treatments for a specific pancreatic cancer patient. PMID:24833909
Exome sequencing reveals a potential mutational trajectory and treatments for a specific pancreatic cancer patient. PMID:24833909
Structure-functional prediction and analysis of cancer mutation effects in protein kinases. PMID:24817905
Frequent mutations in EGFR, KRAS and TP53 genes in human lung cancer tumors detected by ion torrent DNA sequencing. PMID:24760004
Prediction and prioritization of rare oncogenic mutations in the cancer Kinome using novel features and multiple classifiers. PMID:24743239
BRAF and beyond: Tailoring strategies for the individual melanoma patient. PMID:24737949
Multi-marker analysis of circulating cell-free DNA toward personalized medicine for colorectal cancer. PMID:24698732
Genomic profile analysis of diffuse-type gastric cancers. PMID:24690483
The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. PMID:24682267
Comparative functional analysis of DPYD variants of potential clinical relevance to dihydropyrimidine dehydrogenase activity. PMID:24648345
Recurrent PTPRB and PLCG1 mutations in angiosarcoma. PMID:24633157
CHD7 expression predicts survival outcomes in patients with resected pancreatic cancer. PMID:24626090
p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells. PMID:24622841
FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors. PMID:24586741
Inferring the temporal order of cancer gene mutations in individual tumor samples. PMID:24586626
Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma. PMID:24578576
Literature mining of genetic variants for curation: quantifying the importance of supplementary material. PMID:24520105
Ras effector mutant expression suggest a negative regulator inhibits lung tumor formation. PMID:24489653
p120RasGAP is a mediator of rho pathway activation and tumorigenicity in the DLD1 colorectal cancer cell line. PMID:24465899
Beyond E-cadherin: roles of other cadherin superfamily members in cancer. PMID:24442140
α-Lipoic acid suppresses migration and invasion via downregulation of cell surface β1-integrin expression in bladder cancer cells. PMID:24426186
Novel multisample scheme for inferring phylogenetic markers from whole genome tumor profiles. PMID:24407301
A colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α). PMID:24398687
Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. PMID:24398324
Epidermal growth factor receptor mutations in lung adenocarcinoma. PMID:24378644
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition. PMID:24351425
A quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype. PMID:24349113
Phosphatidylinositol 3-Kinase dependent upregulation of the epidermal growth factor receptor upon Flotillin-1 depletion in breast cancer cells. PMID:24304721
wKinMut: an integrated tool for the analysis and interpretation of mutations in human protein kinases. PMID:24289158
CNVannotator: a comprehensive annotation server for copy number variation in the human genome. PMID:24244640
Alcohol interacts with genetic alteration of the Hippo tumor suppressor pathway to modulate tissue growth in Drosophila. PMID:24205337
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. PMID:24162739
Identification of candidate genes for lung cancer somatic mutation test kits. PMID:24130455
Epigenetic inactivation of microRNA-34b/c predicts poor disease-free survival in early-stage lung adenocarcinoma. PMID:24130071
IGFBP2/FAK pathway is causally associated with dasatinib resistance in non-small cell lung cancer cells. PMID:24130049
EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers. PMID:24071938
Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides. PMID:24041868
The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. PMID:24029233
Low-copy piggyBac transposon mutagenesis in mice identifies genes driving melanoma. PMID:24003131
The structural mechanism of KCNH-channel regulation by the eag domain. PMID:23975098
E2F-7 couples DNA damage-dependent transcription with the DNA repair process. PMID:23974101
Combining erlotinib and cetuximab is associated with activity in patients with non-small cell lung cancer (including squamous cell carcinomas) and wild-type EGFR or resistant mutations. PMID:23963360
USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy. PMID:23937906
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. PMID:23934108
Genetics and epigenetics of sporadic thyroid cancer. PMID:23933154
The BAH domain of Rsc2 is a histone H3 binding domain. PMID:23907388
PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system. PMID:23888070
Detection of EGFRvIII mutant DNA in the peripheral blood of brain tumor patients. PMID:23877363
Somatic mutation, genomic variation, and neurological disease. PMID:23828942
Revealing selection in cancer using the predicted functional impact of cancer mutations. Application to nomination of cancer drivers. PMID:23819556
A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma. PMID:23709298
Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer. PMID:23688269
A novel fully automated molecular diagnostic system (AMDS) for colorectal cancer mutation detection. PMID:23671647
Distinct types of disorder in the human proteome: functional implications for alternative splicing. PMID:23633940
Predicting the functional consequences of cancer-associated amino acid substitutions. PMID:23620363
Prognostic microRNA/mRNA signature from the integrated analysis of patients with invasive breast cancer. PMID:23589849
Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. PMID:23552377
Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. PMID:23551194
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. PMID:23550210
High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer. PMID:23548132
Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing. PMID:23496902
Linking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling. PMID:23408876
Using aptamers for cancer biomarker discovery. PMID:23401749
SurfaceomeDB: a cancer-orientated database for genes encoding cell surface proteins. PMID:23390370
Development and characterization of a bladder cancer xenograft model using patient-derived tumor tissue. PMID:23384396
Identification of somatic and germline mutations using whole exome sequencing of congenital acute lymphoblastic leukemia. PMID:23379653
Visualizing multidimensional cancer genomics data. PMID:23363777
Collections of simultaneously altered genes as biomarkers of cancer cell drug response. PMID:23338612
High-throughput mutation profiling of primary and metastatic endometrial cancers identifies KRAS, FGFR2 and PIK3CA to be frequently mutated. PMID:23300780
Penile cancer: current therapy and future directions. PMID:23293117
Identifying the status of genetic lesions in cancer clinical trial documents using machine learning. PMID:23282337
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. PMID:23251002
Prognostic and predictive roles of KRAS mutation in colorectal cancer. PMID:23202889
Reconstructing skin cancers using animal models. PMID:23179861
Building a statistical model for predicting cancer genes. PMID:23166609
Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system. PMID:23152778
ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data. PMID:23143107
Aberrations in the epidermal growth factor receptor gene in 958 patients with diverse advanced tumors: implications for therapy. PMID:23139256
Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers. PMID:23134728
Molecular evidence for the bi-clonal origin of neuroendocrine tumor derived metastases. PMID:23127113
Vemurafenib: targeted inhibition of mutated BRAF for treatment of advanced melanoma and its potential in other malignancies. PMID:23116250
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. PMID:23103869
Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly. PMID:23100325
DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours. PMID:23068969
Interpretation of the consequences of mutations in protein kinases: combined use of bioinformatics and text mining. PMID:23055974
Retrospective analysis of KRAS status in metastatic colorectal cancer patients: a single-center feasibility study. PMID:23028236
Whole exome sequencing of pediatric gastric adenocarcinoma reveals an atypical presentation of Li-Fraumeni syndrome. PMID:23015295
Activating BRAF gene mutations are uncommon in hormone refractory prostate cancer in Caucasian patients. PMID:22966370
EnrichNet: network-based gene set enrichment analysis. PMID:22962466
Exploring functional variant discovery in non-coding regions with SInBaD. PMID:22941663
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. PMID:22941188
Wnt antagonist SFRP1 functions as a secreted mediator of senescence. PMID:22927647
Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations. PMID:22923130
Effect of KRAS codon13 mutations in patients with advanced colorectal cancer (advanced CRC) under oxaliplatin containing chemotherapy. Results from a translational study of the AIO colorectal study group. PMID:22876876
Comprehensive mutation analysis in colorectal flat adenomas. PMID:22848674
Prospective, high-throughput molecular profiling of human gliomas. PMID:22821383
Ubiquitin C-terminal hydrolase l1 in tumorigenesis. PMID:22811913
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. PMID:22805292
The ERBB network: at last, cancer therapy meets systems biology. PMID:22785351
miR-34 - a microRNA replacement therapy is headed to the clinic. PMID:22783274
A case of synchronous pancreatic ductal adenocarcinoma and ovarian mucinous cystic neoplasm: use of kras mutation molecular phenotyping to demonstrate independent primary origin. PMID:22690261
Expression of proto-oncogene KIT is up-regulated in subset of human meningiomas. PMID:22672386
GeLC-MRM quantitation of mutant KRAS oncoprotein in complex biological samples. PMID:22671702
Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors. PMID:22628563
Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents. PMID:22576213
Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K. PMID:22576130
Alpha lipoic acid selectively inhibits proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells. PMID:22573927
Allele specific locked nucleic acid quantitative PCR (ASLNAqPCR): an accurate and cost-effective assay to diagnose and quantify KRAS and BRAF mutation. PMID:22558339
3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PMID:22514694
Somatic activation of AKT3 causes hemispheric developmental brain malformations. PMID:22500628
Perspectives on personalized cancer care. PMID:22489325
Molecular prescreening to select patient population in early clinical trials. PMID:22473105
Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells. PMID:22461507
Exploring the cancer genome in the era of next-generation sequencing. PMID:22460448
Systematic analysis of genotype-specific drug responses in cancer. PMID:22422301
Myc proteins in brain tumor development and maintenance. PMID:22348395
Incorporating molecular and functional context into the analysis and prioritization of human variants associated with cancer. PMID:22319177
From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. PMID:22293185
Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways. PMID:22262169
A mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesis. PMID:22241976
Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. PMID:22197930
Signal control through Raf: in sickness and in health. PMID:22143568
Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. PMID:22071650
Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival. PMID:22048815
Are KRAS/BRAF mutations potent prognostic and/or predictive biomarkers in colorectal cancers? PMID:22043994
A framework to select clinically relevant cancer cell lines for investigation by establishing their molecular similarity with primary human cancers. PMID:22012889
The energy landscape analysis of cancer mutations in protein kinases. PMID:21998754
High throughput interrogation of somatic mutations in high grade serous cancer of the ovary. PMID:21931712
APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis. PMID:21886810
Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling? PMID:21859557
Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR). PMID:21835029
Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine. PMID:21781349
KRAS Mouse Models: Modeling Cancer Harboring KRAS Mutations. PMID:21779503
High chromosome number in hematological cancer cell lines is a negative predictor of response to the inhibition of Aurora B and C by GSK1070916. PMID:21762492
Molecular biology of pancreatic cancer. PMID:21734801
Integrative computational biology for cancer research. PMID:21691773
Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. PMID:21680795
The application of gene co-expression network reconstruction based on CNVs and gene expression microarray data in breast cancer. PMID:21611746
Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. PMID:21575862
Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma. PMID:21575252
FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. PMID:21503901
CREBBP mutations in relapsed acute lymphoblastic leukaemia. PMID:21390130
A bioinformatics workflow for variant peptide detection in shotgun proteomics. PMID:21389108
Synergistic effect between erlotinib and MEK inhibitors in KRAS wild-type human pancreatic cancer cells. PMID:21385921
Meet me halfway: when genomics meets structural bioinformatics. PMID:21350909
A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas. PMID:21266528
Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery. PMID:21208444
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. PMID:21187329
Co-conserved features associated with cis regulation of ErbB tyrosine kinases. PMID:21179209
MU2A--reconciling the genome and transcriptome to determine the effects of base substitutions. PMID:21149339
COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma. PMID:21110880
Pre-clinical drug prioritization via prognosis-guided genetic interaction networks. PMID:21085674
Prediction of human protein-protein interaction by a mixed Bayesian model and its application to exploring underlying cancer-related pathway crosstalk. PMID:20943681
A mathematical framework to determine the temporal sequence of somatic genetic events in cancer. PMID:20864632
Epigenetics of renal cell carcinoma: the path towards new diagnostics and therapeutics. PMID:20815920
Important role of indels in somatic mutations of human cancer genes. PMID:20807447
Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations. PMID:20712882
Clinical relevance of KRAS in human cancers. PMID:20617134
HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer. PMID:20604919
Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. PMID:20570894
Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa. PMID:20492640
Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine. PMID:20432502
Disruption of p73-MDM2 binding synergizes with gemcitabine to induce apoptosis in HuCCT1 cholangiocarcinoma cell line with p53 mutation. PMID:20422343
Comprehensive mapping of the human kinome to epidermal growth factor receptor signaling. PMID:20421302
The analysis of PIK3CA mutations in gastric carcinoma and metanalysis of literature suggest that exon-selectivity is a signature of cancer type. PMID:20398348
A cancer derived mutation in the retinoblastoma gene with a distinct defect for LXCXE dependent interactions. PMID:20298605
Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells. PMID:20193846
U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line. PMID:20126413
Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer. PMID:20108112
Deregulation of H3K27 methylation in cancer. PMID:20104248
CanProVar: a human cancer proteome variation database. PMID:20052754
Regulation of cell signalling by uPAR. PMID:20027185
Bi-directional SIFT predicts a subset of activating mutations. PMID:20011534
Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine. PMID:19935793
Our changing view of the genomic landscape of cancer. PMID:19918804
ChimerDB 2.0--a knowledgebase for fusion genes updated. PMID:19906715
Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cells. PMID:19848582
Sequence and structure signatures of cancer mutation hotspots in protein kinases. PMID:19834613
Extraction of human kinase mutations from literature, databases and genotyping studies. PMID:19758464
Romidepsin inhibits Ras-dependent growth transformation of NIH 3T3 fibroblasts and RIE-1 epithelial cells independently of Ras signaling inhibition. PMID:19682393
9-Aminoacridine inhibition of HIV-1 Tat dependent transcription. PMID:19630958
SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis. PMID:19622832
FancyGene: dynamic visualization of gene structures and protein domain architectures on genomic loci. PMID:19542150
Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. PMID:19451690
A genomic strategy to elucidate modules of oncogenic pathway signaling networks. PMID:19362539
Utilizing the molecular gateway: the path to personalized cancer management. PMID:19246616
Functional copy-number alterations in cancer. PMID:18784837
Comprehensive genomic characterization defines human glioblastoma genes and core pathways. PMID:18772890
Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients. PMID:18594528
Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients. PMID:18577988
Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression. PMID:18492263
Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins. PMID:18490377
Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. PMID:18440854
Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspective. PMID:18397526
Sequence variation in the human transcription factor gene POU5F1. PMID:18254969
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia. PMID:18252861
Mutational analysis of Rac2 in gliomas. PMID:18217210
Characterizing the cancer genome in lung adenocarcinoma. PMID:17982442
MethyCancer: the database of human DNA methylation and cancer. PMID:17890243
Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia. PMID:17494858
From bytes to bedside: data integration and computational biology for translational cancer research. PMID:17319736
COSMIC 2005. PMID:16421597
ChimerDB--a knowledgebase for fusion sequences. PMID:16381848
COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer PubMed citations: 273.

273 articles citing: COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer

Identification of lung cancer drivers by comparison of the observed and the expected numbers of missense and nonsense mutations in individual human genes. PMID:35634240
Establishment and characterization of NCC-DMM1-C1, a novel patient-derived cell line of desmoplastic malignant pleural mesothelioma. PMID:35069873
DCMP: database of cancer mutant protein domains. PMID:34791106
Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers. PMID:34702252
Next Generation Sequencing of Tumor and Matched Plasma Samples: Identification of Somatic Variants in ctDNA From Ovarian Cancer Patients. PMID:34660321
A Comprehensive Circulating Tumor DNA Assay for Detection of Translocation and Copy-Number Changes in Pediatric Sarcomas. PMID:34353895
Epigenetic Mechanisms Involved in HCV-Induced Hepatocellular Carcinoma (HCC). PMID:34336665
Web tools to perform long non-coding RNAs analysis in oncology research. PMID:34296748
The emerging role of the KCTD proteins in cancer. PMID:34001146
Preclinical Models for Bladder Cancer Research. PMID:33958154
Genomic landscape of extraordinary responses in metastatic breast cancer. PMID:33837242
Cutaneous Squamous Cell Carcinoma in the Age of Immunotherapy. PMID:33800195
Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation. PMID:33435458
A human surfactant B deficiency air-liquid interface cell culture model suitable for gene therapy applications. PMID:33426150
Molecular characteristics of primary pulmonary lymphoepithelioma-like carcinoma based on integrated genomic analyses. PMID:33414372
Integrative analysis of long extracellular RNAs reveals a detection panel of noncoding RNAs for liver cancer. PMID:33391469
Whole-exome sequencing of non-BRCA1/BRCA2 mutation carrier cases at high-risk for hereditary breast/ovarian cancer. PMID:33326660
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system. PMID:33311466
Deep phylogeny of cancer drivers and compensatory mutations. PMID:33009502
Drivers underpinning the malignant transformation of giant cell tumour of bone. PMID:32866294
GLI1 activation is a key mechanism of erlotinib resistance in human non-small cell lung cancer. PMID:32863909
Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate. PMID:32839463
PertInInt: An Integrative, Analytical Approach to Rapidly Uncover Cancer Driver Genes with Perturbed Interactions and Functionalities. PMID:32711844
Human genes differ by their UV sensitivity estimated through analysis of UV-induced silent mutations in melanoma. PMID:32643855
Human gene and disease associations for clinical-genomics and precision medicine research. PMID:32508008
Xanthomas Can Be Misdiagnosed and Mistreated in Homozygous Familial Hypercholesterolemia Patients: A Call for Increased Awareness Among Dermatologists and Health Care Practitioners. PMID:32489792
HECTD1 regulates the expression of SNAIL: Implications for epithelial‑mesenchymal transition. PMID:32319576
CScape-somatic: distinguishing driver and passenger point mutations in the cancer genome. PMID:32282885
TGPred: a tumor gene prediction webserver for analyzing structural and functional impacts of variants. PMID:32246141
Temporal activation of WNT/β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth. PMID:32238882
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. PMID:32025015
TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. PMID:31953436
Genomic profiling of multiple breast cancer reveals inter-lesional heterogeneity. PMID:31929516
Candidate Genes and MiRNAs Linked to the Inverse Relationship Between Cancer and Alzheimer's Disease: Insights From Data Mining and Enrichment Analysis. PMID:31608105
Identification of predictive genetic signatures of Cytarabine responsiveness using a 3D acute myeloid leukaemia model. PMID:31449347
Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer. PMID:31287991
Computational analysis of receptor tyrosine kinase inhibitors and cancer metabolism: implications for treatment and discovery of potential therapeutic signatures. PMID:31208363
Pathogenicity and functional impact of non-frameshifting insertion/deletion variation in the human genome. PMID:31199787
Design of a liver cancer-specific selector for the analysis of circulating tumor DNA. PMID:31186754
Utility of cfDNA Fragmentation Patterns in Designing the Liquid Biopsy Profiling Panels to Improve Their Sensitivity. PMID:30915108
An Interactive Resource to Probe Genetic Diversity and Estimated Ancestry in Cancer Cell Lines. PMID:30894373
Most canine ameloblastomas harbor HRAS mutations, providing a novel large-animal model of RAS-driven cancer. PMID:30741938
Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines. PMID:30485824
Spectrum of the KIT Gene Mutations in Gastrointestinal Stromal Tumors in Arab Patients. PMID:30362320
Generation of a TP53-modified porcine cancer model by CRISPR/Cas9-mediated gene modification in porcine zygotes via electroporation. PMID:30352075
Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy. PMID:30309915
Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development. PMID:30262843
Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers. PMID:30254182
SMART Cancer Navigator: A Framework for Implementing ASCO Workshop Recommendations to Enable Precision Cancer Medicine. PMID:30238071
Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular stress. PMID:30224719
Comprehensive genetic diagnosis of acute myeloid leukemia by next-generation sequencing. PMID:30190345
SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis. PMID:30177679
Identification of Two Novel Mutations in KDM3A Regulatory Gene in Iranian Infertile Males. PMID:30053768
Quantitative Crotonylome Analysis Expands the Roles of p300 in the Regulation of Lysine Crotonylation Pathway. PMID:29932303
Selenium-binding protein 1 is down-regulated in malignant melanoma. PMID:29535818
The Integrated Genomic Landscape of Thymic Epithelial Tumors. PMID:29438696
Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations. PMID:29295717
Comprehensive molecular biomarker identification in breast cancer brain metastases. PMID:29287594
STR profiling and Copy Number Variation analysis on single, preserved cells using current Whole Genome Amplification methods. PMID:29215049
Contemporary genetic testing in inherited cardiac disease: tools, ethical issues, and clinical applications. PMID:29176389
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas. PMID:29100075
Racial disparities in patient survival and tumor mutation burden, and the association between tumor mutation burden and cancer incidence rate. PMID:29057889
Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11. PMID:29018080
Insights from animal models of bladder cancer: recent advances, challenges, and opportunities. PMID:28915710
Identification of a p53-repressed gene module in breast cancer cells. PMID:28915555
CUT-PCR: CRISPR-mediated, ultrasensitive detection of target DNA using PCR. PMID:28846115
Direct detection of early-stage cancers using circulating tumor DNA. PMID:28814544
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma. PMID:28810145
Loss of MutL Disrupts CHK2-Dependent Cell-Cycle Control through CDK4/6 to Promote Intrinsic Endocrine Therapy Resistance in Primary Breast Cancer. PMID:28801307
Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth. PMID:28709411
Performance of four modern whole genome amplification methods for copy number variant detection in single cells. PMID:28611458
Ultrasensitive detection of acute myeloid leukemia minimal residual disease using single molecule molecular inversion probes. PMID:28572161
Characterization of potential driver mutations involved in human breast cancer by computational approaches. PMID:28477017
Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma. PMID:28463229
Comparative study of joint bioinformatics analysis of underlying potential of 'neurimmiR', miR-212-3P/miR-132-3P, being involved in epilepsy and its emerging role in human cancer. PMID:28380454
Hypermutation signature reveals a slippage and realignment model of translesion synthesis by Rev3 polymerase in cisplatin-treated yeast. PMID:28223526
The subclonal structure and genomic evolution of oral squamous cell carcinoma revealed by ultra-deep sequencing. PMID:28157713
Next-Generation Sequencing in Oncology: Genetic Diagnosis, Risk Prediction and Cancer Classification. PMID:28146134
Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations. PMID:28098136
Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions. PMID:27923773
Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers. PMID:27901097
Computational approaches for the identification of cancer genes and pathways. PMID:27863091
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors. PMID:27684276
Comprehensive comparison of molecular portraits between cell lines and tumors in breast cancer. PMID:27556158
2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells. PMID:27551077
In-depth molecular profiling of the biphasic components of uterine carcinosarcomas. PMID:27499902
Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development. PMID:27494029
Challenges in identifying cancer genes by analysis of exome sequencing data. PMID:27417679
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. PMID:27374120
Identification of Cancer Related Genes Using a Comprehensive Map of Human Gene Expression. PMID:27322383
Somatic mutations in histiocytic sarcoma identified by next generation sequencing. PMID:27259537
Integrative Genomics and Transcriptomics Analysis Reveals Potential Mechanisms for Favorable Prognosis of Patients with HPV-Positive Head and Neck Carcinomas. PMID:27108969
A bioinformatics approach for precision medicine off-label drug drug selection among triple negative breast cancer patients. PMID:27107440
SMART precision cancer medicine: a FHIR-based app to provide genomic information at the point of care. PMID:27018265
Altered RNA editing in 3' UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors. PMID:26980570
Mosaic Activating Mutations in FGFR1 Cause Encephalocraniocutaneous Lipomatosis. PMID:26942290
Gene Variant Databases and Sharing: Creating a Global Genomic Variant Database for Personalized Medicine. PMID:26931283
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. PMID:26928227
Endogenous network states predict gain or loss of functions for genetic mutations in hepatocellular carcinoma. PMID:26911487
The diagnostic application of RNA sequencing in patients with thyroid cancer: an analysis of 851 variants and 133 fusions in 524 genes. PMID:26818556
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function. PMID:26700806
Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2A/B Deletion. PMID:26634163
Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma. PMID:26619122
Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival. PMID:26585234
Adaptive Evolution Coupled with Retrotransposon Exaptation Allowed for the Generation of a Human-Protein-Specific Coding Gene That Promotes Cancer Cell Proliferation and Metastasis in Both Haematological Malignancies and Solid Tumours: The Extraordinary Case of MYEOV Gene. PMID:26568894
Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case. PMID:26555092
Determining the origin of synchronous multifocal bladder cancer by exome sequencing. PMID:26553077
Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. PMID:26503472
An evidence-based knowledgebase of metastasis suppressors to identify key pathways relevant to cancer metastasis. PMID:26486520
Oncogenomic portals for the visualization and analysis of genome-wide cancer data. PMID:26484415
Next-Generation Sequencing in Clinical Molecular Diagnostics of Cancer: Advantages and Challenges. PMID:26473927
Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms. PMID:26340370
Increasing Nucleosome Occupancy Is Correlated with an Increasing Mutation Rate so Long as DNA Repair Machinery Is Intact. PMID:26308346
Next-generation sequencing to guide cancer therapy. PMID:26221189
Implementation of a Molecular Tumor Board: The Impact on Treatment Decisions for 35 Patients Evaluated at Dartmouth-Hitchcock Medical Center. PMID:26205736
Genetic profiles of cervical tumors by high-throughput sequencing for personalized medical care. PMID:26155992
Receptor tyrosine kinase mutations in developmental syndromes and cancer: two sides of the same coin. PMID:26152202
Functional annotation of HOT regions in the human genome: implications for human disease and cancer. PMID:26113264
Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells. PMID:26084335
The road from next-generation sequencing to personalized medicine. PMID:26000024
Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib. PMID:25969993
Methylation Abnormalities in Mammary Carcinoma: The Methylation Suicide Hypothesis. PMID:25960928
Genomic Characterization of Non-Small-Cell Lung Cancer in African Americans by Targeted Massively Parallel Sequencing. PMID:25918285
Cis-regulatory somatic mutations and gene-expression alteration in B-cell lymphomas. PMID:25903198
BRAF mutations in non-small cell lung cancer. PMID:25870796
Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells. PMID:25853217
Multiple mechanisms of MYCN dysregulation in Wilms tumour. PMID:25749049
Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M(3)P). PMID:25743686
Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients. PMID:25742471
Viable pigs with a conditionally-activated oncogenic KRAS mutation. PMID:25716163
Scripps Genome ADVISER: Annotation and Distributed Variant Interpretation SERver. PMID:25706643
Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization. PMID:25627682
Genetic lesions in diffuse large B-cell lymphomas. PMID:25605746
Churchill: an ultra-fast, deterministic, highly scalable and balanced parallelization strategy for the discovery of human genetic variation in clinical and population-scale genomics. PMID:25600152
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. PMID:25531777
The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis. PMID:25486477
Immune status, strain background, and anatomic site of inoculation affect mouse papillomavirus (MmuPV1) induction of exophytic papillomas or endophytic trichoblastomas. PMID:25474466
Clinical characteristics and course of 63 patients with BRAF mutant lung cancers. PMID:25436800
Insights into genetic and epigenetic determinants with impact on vitamin d signaling and cancer association studies: the case of thyroid cancer. PMID:25414832
Single-Tube Mutation Scanning of The Epidermal Growth Factor Receptor Gene Using Multiplex LATE-PCR and Lights-On/Lights-Off Probes. PMID:25411647
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes. PMID:25401301
Cancer3D: understanding cancer mutations through protein structures. PMID:25392415
Human cancer databases (review). PMID:25369839
Receptors for luteinizing hormone-releasing hormone (GnRH) as therapeutic targets in triple negative breast cancers (TNBC). PMID:25293576
Multi-stage genome-wide association study identifies new susceptibility locus for testicular germ cell tumour on chromosome 3q25. PMID:25281660
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. PMID:25240283
Diverse modes of genomic alteration in hepatocellular carcinoma. PMID:25159915
The determinants of head and neck cancer: Unmasking the PI3K pathway mutations. PMID:25126449
Different mutational characteristics of TSG in cell lines and surgical specimens. PMID:25119593
The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression. PMID:25066119
Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. PMID:24898756
Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. PMID:24891321
Transduction motif analysis of gastric cancer based on a human signaling network. PMID:24838641
Application of genomic principles to pharmacotherapy of cancer. PMID:24761016
Prediction and prioritization of rare oncogenic mutations in the cancer Kinome using novel features and multiple classifiers. PMID:24743239
Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing. PMID:24728327
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. PMID:24705333
A framework for organizing cancer-related variations from existing databases, publications and NGS data using a High-performance Integrated Virtual Environment (HIVE). PMID:24667251
Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition. PMID:24616105
Benchmarking infrastructure for mutation text mining. PMID:24568600
Identification of novel point mutations in splicing sites integrating whole-exome and RNA-seq data in myeloproliferative diseases. PMID:24498620
Non-synonymous variations in cancer and their effects on the human proteome: workflow for NGS data biocuration and proteome-wide analysis of TCGA data. PMID:24467687
Genomic characterization of three urinary bladder cancer cell lines: understanding genomic types of urinary bladder cancer. PMID:24459064
MutPred Splice: machine learning-based prediction of exonic variants that disrupt splicing. PMID:24451234
Simultaneous characterization of somatic events and HPV-18 integration in a metastatic cervical carcinoma patient using DNA and RNA sequencing. PMID:24418928
Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma. PMID:24379610
Rare EGFR exon 18 and exon 20 mutations in non-small-cell lung cancer on 10 117 patients: a multicentre observational study by the French ERMETIC-IFCT network. PMID:24285021
Genomic and transcriptomic plasticity in treatment-naive ovarian cancer. PMID:24221193
Detection of up to 65% of Precancerous Lesions of the Human Colon and Rectum by Mutation Analysis of APC, K-Ras, B-Raf and CTNNB1. PMID:24212608
Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. PMID:24183448
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. PMID:24161930
The Janus kinases inhibitor AZD1480 attenuates growth of small cell lung cancers in vitro and in vivo. PMID:24158701
Reassessing target antigens for adoptive T-cell therapy. PMID:24142051
The next-generation sequencing revolution and its impact on genomics. PMID:24074859
IntOGen-mutations identifies cancer drivers across tumor types. PMID:24037244
The integrated landscape of driver genomic alterations in glioblastoma. PMID:23917401
Search for signatures in miRNAs associated with cancer. PMID:23861569
Two Distinct Categories of Focal Deletions in Cancer Genomes. PMID:23805207
The relative timing of mutations in a breast cancer genome. PMID:23762276
Genome Maps, a new generation genome browser. PMID:23748955
Shimmer: detection of genetic alterations in tumors using next-generation sequence data. PMID:23620360
Annotation of genes having candidate somatic mutations in acute myeloid leukemia with whole-exome sequencing using concept lattice analysis. PMID:23613681
Identification of nine genomic regions of amplification in urothelial carcinoma, correlation with stage, and potential prognostic and therapeutic value. PMID:23593348
Epidermal growth factor receptor as a therapeutic target in glioblastoma. PMID:23575987
Comprehensive molecular oncogenomic profiling and miRNA analysis of prostate cancer. PMID:23573364
Somatic mutations in exocrine pancreatic tumors: association with patient survival. PMID:23565280
Drosophila SETs its sights on cancer: Trr/MLL3/4 COMPASS-like complexes in development and disease. PMID:23459940
Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans. PMID:23445218
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. PMID:23415222
Power in numbers: meta-analysis to identify inhibitor-sensitive tumor genotypes. PMID:23403632
HeurAA: accurate and fast detection of genetic variations with a novel heuristic amplicon aligner program for next generation sequencing. PMID:23349847
Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers. PMID:23340843
Interplay of microRNAs, transcription factors and target genes: linking dynamic expression changes to function. PMID:23335783
Disentangling function from topology to infer the network properties of disease genes. PMID:23324116
Regulation of ROCK activity in cancer. PMID:23204112
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling. PMID:23178117
Increased frequency of single base substitutions in a population of transcripts expressed in cancer cells. PMID:23137041
Next-generation sequencing in breast cancer: first take home messages. PMID:23014189
Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family. PMID:22992069
Network enrichment analysis: extension of gene-set enrichment analysis to gene networks. PMID:22966941
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. PMID:22941189
Biomarkers of response to Akt inhibitor MK-2206 in breast cancer. PMID:22932669
Recurrent R-spondin fusions in colon cancer. PMID:22895193
Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec. PMID:22761113
Mathematical and statistical modeling in cancer systems biology. PMID:22754537
Analyzing large biological datasets with association networks. PMID:22638576
Melanoma genome sequencing reveals frequent PREX2 mutations. PMID:22622578
Phage displayed peptides/antibodies recognizing growth factors and their tyrosine kinase receptors as tools for anti-cancer therapeutics. PMID:22606042
Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. PMID:22588879
Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance. PMID:22547687
An analysis of substitution, deletion and insertion mutations in cancer genes. PMID:22492711
Liverome: a curated database of liver cancer-related gene signatures with self-contained context information. PMID:22369201
PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. PMID:22271473
Bioinformatics for personal genome interpretation. PMID:22247263
'Omic approaches to preventing or managing metastatic breast cancer. PMID:22216753
Mutability and mutational spectrum of chromosome transmission fidelity genes. PMID:22198145
Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness. PMID:22179824
Condensin dysfunction in human cells induces nonrandom chromosomal breaks in anaphase, with distinct patterns for both unique and repeated genomic regions. PMID:22179743
β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. PMID:22172720
Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. PMID:22158273
IGDB.NSCLC: integrated genomic database of non-small cell lung cancer. PMID:22139933
Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer. PMID:22110708
Ensembl 2012. PMID:22086963
myKaryoView: a light-weight client for visualization of genomic data. PMID:22046276
Temporal dissection of tumorigenesis in primary cancers. PMID:21984974
Integrative cancer genomics (IntOGen) in Biomart. PMID:21903633
Different phenotypic consequences of simultaneous versus stepwise Apc loss. PMID:21892206
Ensembl BioMarts: a hub for data retrieval across taxonomic space. PMID:21785142
Analysis of Somatic Mutations in Cancer: Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases. PMID:21701703
Exome sequencing reveals comprehensive genomic alterations across eight cancer cell lines. PMID:21701589
Sequence analysis of 515 kinase genes in chronic lymphocytic leukemia. PMID:21701494
Predicting selective drug targets in cancer through metabolic networks. PMID:21694718
Limited importance of the dominant-negative effect of TP53 missense mutations. PMID:21668955
The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence. PMID:21642372
Data mining using the Catalogue of Somatic Mutations in Cancer BioMart. PMID:21609966
Protocol matters: which methylome are you actually studying? PMID:21566704
The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PMID:21552543
Mutations in CEP57 cause mosaic variegated aneuploidy syndrome. PMID:21552266
Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. PMID:21533036
Genomic evidence of pre-invasive clonal expansion, dispersal and progression in bronchial dysplasia. PMID:21506132
Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. PMID:21483012
Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, Condel. PMID:21457909
Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. PMID:21440986
Integrated metabolome and transcriptome analysis of the NCI60 dataset. PMID:21342567
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. PMID:21329883
Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency. PMID:21262837
A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer. PMID:21227397
PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors. PMID:21216929
The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression. PMID:21203412
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. PMID:21187329
The genetic landscape of the childhood cancer medulloblastoma. PMID:21163964
ALK inhibition for non-small cell lung cancer: from discovery to therapy in record time. PMID:21156280
dbDEMC: a database of differentially expressed miRNAs in human cancers. PMID:21143814
Exploring the link between germline and somatic genetic alterations in breast carcinogenesis. PMID:21124932
COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma. PMID:21110880
Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing. PMID:21097718
Induction of human epithelial stem/progenitor expansion by FOXM1. PMID:21062979
IGRhCellID: integrated genomic resources of human cell lines for identification. PMID:21051335
The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction. PMID:21047778
Ensembl 2011. PMID:21045057
A self-validating quantitative mass spectrometry method for assessing the accuracy of high-content phosphoproteomic experiments. PMID:20972267
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. PMID:20952405
CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowledge. PMID:20952398
genenames.org: the HGNC resources in 2011. PMID:20929869
Accumulation of driver and passenger mutations during tumor progression. PMID:20876136
Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms. PMID:20823136
Important role of indels in somatic mutations of human cancer genes. PMID:20807447
Validating cancer drug targets through chemical genetics. PMID:20708654
Cell signaling by receptor tyrosine kinases. PMID:20602996
Mutations for the people. PMID:20461736
KRAS status analysis and anti-EGFR therapies: is comprehensiveness a biologist's fancy or a clinical necessity? PMID:20160721
Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer. PMID:20108112
The 2010 Nucleic Acids Research Database Issue and online Database Collection: a community of data resources. PMID:19965766

Data mining using the Catalogue of Somatic Mutations in Cancer BioMart PubMed citations: 29.

http://dx.doi.org/10.1093/nar/gku1075

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cancer
metasource: Fairsharing.org
version: FAIRsharing.org: COSMIC; Catalogue of Somatic Mutations in Cancer; DOI: https://doi.org/10.25504/FAIRsharing.s5zmbp; Last edited: March 8, 2021, 10:32 a.m.; Last accessed: Jan 03 2022 7:08 p.m.

genome annotation
metasource: Fairsharing.org
version: FAIRsharing.org: COSMIC; Catalogue of Somatic Mutations in Cancer; DOI: https://doi.org/10.25504/FAIRsharing.s5zmbp; Last edited: March 8, 2021, 10:32 a.m.; Last accessed: Jan 03 2022 7:08 p.m.

somatic mutation
metasource: Fairsharing.org
version: FAIRsharing.org: COSMIC; Catalogue of Somatic Mutations in Cancer; DOI: https://doi.org/10.25504/FAIRsharing.s5zmbp; Last edited: March 8, 2021, 10:32 a.m.; Last accessed: Jan 03 2022 7:08 p.m.

tumor
metasource: Fairsharing.org
version: FAIRsharing.org: COSMIC; Catalogue of Somatic Mutations in Cancer; DOI: https://doi.org/10.25504/FAIRsharing.s5zmbp; Last edited: March 8, 2021, 10:32 a.m.; Last accessed: Jan 03 2022 7:08 p.m.

human genes and diseases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

cancer gene databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

genetic variation
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:57.636780

oncology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:57.636780

data mining
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:57.636780

rare diseases
metasource: bio.tools
version: extracted_at: 2022-11-04T11:30:57.636780

cancer genome annotation somatic mutation tumor human genes and diseases cancer-related genes genetic variation oncology data mining rare diseases

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Database of Somatic Mutations in Normal Cells

SomaMutDB

Minimum Information About Somatic Mutation

CancerGenes

IARC TP53 Database

SomamiR

mSignatureDB

MoKCa

Network of Cancer Genes

MethHC

Candidate Cancer Gene Database

CanGEM

Cancer3D

MutationAligner

COLT-Cancer

Catalogue of Life

ICGC Data Portal

The Database of Human DNA Methylation and Cancer

Clinical Interpretation of Variants in Cancer

The Cancer Genome Atlas