Allosteric Mutation Analysis and Polymorphism of Signaling database
Names
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Allosteric Mutation Analysis and Polymorphism of Signaling database
metasource: Fairsharing.org
version: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
AlloMAPS
metasource: Fairsharing.org
version: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
AlloMAPS 2
metasource: bio.tools
version: extracted_at: 2022-11-04T11:23:05.148648
allomaps_2
metasource: bio.tools
version: extracted_at: 2022-11-04T11:23:05.148648
Names
More detailed information about this field from each metasource.
Allosteric Mutation Analysis and Polymorphism of Signaling database
metasource: Fairsharing.orgversion: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
AlloMAPS
metasource: Fairsharing.orgversion: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
AlloMAPS 2
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:23:05.148648
allomaps_2
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:23:05.148648
Other names: AlloMAPS, AlloMAPS 2, allomaps_2
Names
More detailed information about this field from each metasource.
Allosteric Mutation Analysis and Polymorphism of Signaling database
metasource: Fairsharing.orgversion: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
AlloMAPS
metasource: Fairsharing.orgversion: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
AlloMAPS 2
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:23:05.148648
allomaps_2
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:23:05.148648
The AlloMAPS database provides data on the energetics of communication in proteins with well-documented allosteric regulation, allosteric signalling in PDBselect chains, and allosteric effects of mutations. In addition to energetics of allosteric signaling between known functional and regulatory sites, allosteric modulation caused by the binding to these sites, by SNPs, and by mutations designated by the user can be explored. Allosteric Signaling Maps (ASMs), which are produced via the exhaustive computational scanning for stabilizing and destabilizing mutations and for the modulation range caused by the sequence position are available for each protein/protein chain in the database.
Description
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The AlloMAPS database provides data on the energetics of communication in proteins with well-documented allosteric regulation, allosteric signalling in PDBselect chains, and allosteric effects of mutations. In addition to energetics of allosteric signaling between known functional and regulatory sites, allosteric modulation caused by the binding to these sites, by SNPs, and by mutations designated by the user can be explored. Allosteric Signaling Maps (ASMs), which are produced via the exhaustive computational scanning for stabilizing and destabilizing mutations and for the modulation range caused by the sequence position are available for each protein/protein chain in the database.
metasource: Fairsharing.orgversion: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
AlloMAPS database provides data on the causality and energetics of allosteric communication obtained with the structure-based statistical mechanical model of allostery (SBSMMA). The database contains data on allosteric signaling in three sets of proteins and protein chains: (i) 46 proteins with comprehensively annotated functional and allosteric sites; (ii) 1908 protein chains from PDBselect set of chains with low (<25%) sequence identity; (iii) 33 proteins with more than 50 known pathological SNPs in each molecule. In addition to energetics of allosteric signaling between known functional and regulatory sites, allosteric modulation caused by the binding to these sites, by SNPs, and by mutations designated by the user can be explored. Allosteric Signaling Maps (ASMs), which are produced via the exhaustive computational scanning for stabilizing and destabilizing mutations and for the modulation range caused by the sequence position are available for each protein/protein chain in the database. We propose to use this database for evaluating the effects of allosteric signaling in the search for latent regulatory sites and in the design of allosteric sites and effectors. The database is freely available at: http://allomaps.bii.a-star.edu.sg.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
The database provides data on the energetics of communication in proteins with well-documented allosteric regulation, allosteric signalling in PDBselect chains, and allosteric effects of mutations.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:23:05.148648
Webpage:
http://allomaps.bii.a-star.edu.sgWebpage
More detailed information about this field from each metasource.
http://allomaps.bii.a-star.edu.sg
metasource: Fairsharing.orgversion: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:23:05.148648
Licence:
Name: Not licensedLicence name
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Publications:
Publications
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AlloMAPS: allosteric mutation analysis and polymorphism of signaling database
PMID: 30365033
metasource: Fairsharing.org
version: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
https://doi.org/10.1093/nar/gky1028
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
PMID:36169226
metasource: bio.tools
version: extracted_at: 2022-11-04T11:23:05.148648
Publications
More detailed information about this field from each metasource.
AlloMAPS: allosteric mutation analysis and polymorphism of signaling database
PMID: 30365033
metasource: Fairsharing.org
version: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
https://doi.org/10.1093/nar/gky1028
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
PMID:36169226
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:23:05.148648
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AlloMAPS: allosteric mutation analysis and polymorphism of signaling database
PubMed citations: 15.
15 articles citing: AlloMAPS: allosteric mutation analysis and polymorphism of signaling database
Dissecting mutational allosteric effects in alkaline phosphatases associated with different Hypophosphatasia phenotypes: An integrative computational investigation. PMID:35320273
Design and engineering of allosteric communications in proteins. PMID:35180676
Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein. PMID:35063064
Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators. PMID:34900528
Disorder driven allosteric control of protein activity. PMID:34235479
Signaling in the crowded cell. PMID:34218161
Untangling Dual-Targeting Therapeutic Mechanism of Epidermal Growth Factor Receptor (EGFR) Based on Reversed Allosteric Communication. PMID:34070173
Influence of Disease-Causing Mutations on Protein Structural Networks. PMID:33778000
PI3K inhibitors: review and new strategies. PMID:32953006
Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to. PMID:32937901
Conformational Changes Induced by S34Y and R98C Variants in the Death Domain of Myd88. PMID:32266286
The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance. PMID:32182845
MutaBind2: Predicting the Impacts of Single and Multiple Mutations on Protein-Protein Interactions. PMID:32169820
Unraveling allosteric landscapes of allosterome with ASD. PMID:31665428
AlloDriver: a method for the identification and analysis of cancer driver targets. PMID:31069394 - https://doi.org/10.1093/nar/gky1028
- PMID:36169226
Tags:
Tags
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protein
metasource: Fairsharing.org
version: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
signaling
metasource: Fairsharing.org
version: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
single nucleotide polymorphism
metasource: Fairsharing.org
version: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
human genes and diseases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
general polymorphism databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
genetic variation
metasource: bio.tools
version: extracted_at: 2022-11-04T11:23:05.148648
pathology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:23:05.148648
proteomics
metasource: bio.tools
version: extracted_at: 2022-11-04T11:23:05.148648
probes and primers
metasource: bio.tools
version: extracted_at: 2022-11-04T11:23:05.148648
personalised medicine
metasource: bio.tools
version: extracted_at: 2022-11-04T11:23:05.148648
Tags
More detailed information about this field from each metasource.
protein
metasource: Fairsharing.orgversion: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
signaling
metasource: Fairsharing.orgversion: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
single nucleotide polymorphism
metasource: Fairsharing.orgversion: FAIRsharing.org: AlloMAPS; Allosteric Mutation Analysis and Polymorphism of Signaling database; DOI: https://doi.org/10.25504/FAIRsharing.aIe9SA; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 03 2022 7:07 p.m.
human genes and diseases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
general polymorphism databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
genetic variation
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:23:05.148648
pathology
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:23:05.148648
proteomics
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:23:05.148648
probes and primers
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:23:05.148648
personalised medicine
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:23:05.148648
protein signaling single nucleotide polymorphism human genes and diseases polymorphism genetic variation pathology proteomics probes and primers personalised medicine
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