Other names: SISYPHUS database of protein structure alignments, sisyphus

The SISYPHUS database contains manually curated multiple structural alignments constructed for a set of proteins with known three-dimensional structures that have revealed non-trivial structural relationships and whose structural similarity is ambiguous when using standard methods for structure comparison. The multiple alignments in the database comprise common structural motifs, structural domains or oligomeric biological units. Thus they capture a variety of protein structural relationships many of which are biologically relevant. The multiple alignments are grouped into different alignment categories and connected by complex non-hierarchical inter-relationships described by DAGs. The SISYPHUS alignments are displayed with SPICE, a browser that provides an integrated view of protein sequences, structures and their annotations.




protein sequence protein domains and classification structure protein structure proteins

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