Implications of Sphingolipids on Aging and Age-Related Diseases.
PMID:35822041
Prediction of Chronological Age in Healthy Elderly Subjects with Machine Learning from MRI Brain Segmentation and Cortical Parcellation.
PMID:35624966
Biological aging processes underlying cognitive decline and neurodegenerative disease.
PMID:35575089
Nutrient-Response Pathways in Healthspan and Lifespan Regulation.
PMID:35563873
Predicting Chronological Age from DNA Methylation Data: A Machine Learning Approach for Small Datasets and Limited Predictors.
PMID:35505216
DNA Methylation - and Telomere - Based Biological Age Estimation as Markers of Biological Aging in Donors Kidneys.
PMID:35402460
Psychosocial Stress, Glucocorticoid Signaling, and Prostate Cancer Health Disparities in African American Men.
PMID:35252767
The Transcriptome and Methylome of the Developing and Aging Brain and Their Relations to Gliomas and Psychological Disorders.
PMID:35159171
Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging.
PMID:34829864
Genetic Contributions to Prostate Cancer Disparities in Men of West African Descent.
PMID:34820334
Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex.
PMID:34548609
Hierarchy and control of ageing-related methylation networks.
PMID:34534207
DNA methylation of decedent blood samples to estimate the chronological age of human remains.
PMID:34245337
Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases.
PMID:34206738
Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation.
PMID:34140348
TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice.
PMID:34099715
A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheimer's Disease Points for Accelerated Epigenetic Aging in Neurodegeneration.
PMID:33790779
Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children.
PMID:33685492
Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation.
PMID:33602921
Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence.
PMID:33450751
DNA methylation-based age estimation in pediatric healthy tissues and brain tumors.
PMID:33168783
Epigenetic Clock: DNA Methylation in Aging.
PMID:32724310
Epigenetic mechanisms in Alzheimer's disease.
PMID:32669903
DNA Methylation in Neurodegenerative and Cerebrovascular Disorders.
PMID:32210102
Hypermethylation of the Gene Coding for PGC-1α in Peripheral Blood Leukocytes of Patients With Parkinson's Disease.
PMID:32174806
Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice.
PMID:32050516
An analysis of the effect of mu-opioid receptor gene (OPRM1) promoter region DNA methylation on the response of naltrexone treatment of alcohol dependence.
PMID:32029903
DNA Methylation Changes Are Associated With an Incremental Ascent to High Altitude.
PMID:31737045
Differentially methylated gene patterns between age-matched sarcopenic and non-sarcopenic women.
PMID:31508907
The effect of age on DNA methylation in whole blood among Bangladeshi men and women.
PMID:31506065
Epigenetic Markers of Aging Predict the Neural Oscillations Serving Selective Attention.
PMID:31504270
A concise review of human brain methylome during aging and neurodegenerative diseases.
PMID:31462381
Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites.
PMID:31426852
Alzheimer's disease: pathogenesis, diagnostics, and therapeutics.
PMID:31410002
Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo.
PMID:31278326
Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation.
PMID:31136303
Entanglement of Genetics and Epigenetics in Parkinson's Disease.
PMID:30983962
Age-related Disturbances in DNA (hydroxy)methylation in APP/PS1 Mice.
PMID:30746282
DNA methylation in the human frontal cortex reveals a putative mechanism for age-by-disease interactions.
PMID:30696804
In Vitro Neuroprotection of Rat Hippocampal Neurons by Manninotriose and Astragaloside IV Against Corticosterone-Induced Toxicity.
PMID:30562980
Genotype effects contribute to variation in longitudinal methylome patterns in older people.
PMID:30348214
Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression.
PMID:30332397
The Contribution and Therapeutic Potential of Epigenetic Modifications in Alzheimer's Disease.
PMID:30283297
Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model.
PMID:30158856
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex.
PMID:30045751
Combination of resveratrol and 5-azacytydine improves osteogenesis of metabolic syndrome mesenchymal stem cells.
PMID:29999247
Tissue aging: the integration of collective and variant responses of cells to entropic forces over time.
PMID:29908481
Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception.
PMID:29848354
5-Hydroxymethylcytosine alterations in the human postmortem brains of autism spectrum disorder.
PMID:29790956
Into the Fourth Dimension: Dysregulation of Genome Architecture in Aging and Alzheimer's Disease.
PMID:29541020
Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases.
PMID:29527170
DNA-Methylation: Master or Slave of Neural Fate Decisions?
PMID:29449798
Aberrant DNA methylation associated with Alzheimer's disease in the superior temporal gyrus.
PMID:29375678
Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging.
PMID:29203886
Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease.
PMID:29113959
Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration.
PMID:29113750
Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline.
PMID:29084334
Aging as an Epigenetic Phenomenon.
PMID:29081695
Dopamine Transporter Gene Methylation is Associated with Nucleus Accumbens Activation During Reward Processing in Healthy but not Alcohol-Dependent Individuals.
PMID:29030974
Age-related gene expression in luminal epithelial cells is driven by a microenvironment made from myoepithelial cells.
PMID:29016359
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders.
PMID:28928628
DNA Methylation of Synaptic Genes in the Prefrontal Cortex Is Associated with Aging and Age-Related Cognitive Impairment.
PMID:28824413
Genome-wide Methyl-Seq analysis of blood-brain targets of glucocorticoid exposure.
PMID:28557603
Genetic architecture of epigenetic and neuronal ageing rates in human brain regions.
PMID:28516910
Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth.
PMID:28503212
UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures.
PMID:28402695
The epigenetic landscape of age-related diseases: the geroscience perspective.
PMID:28352958
Ageing, neurodegeneration and brain rejuvenation.
PMID:27830812
Environmental Enrichment Modified Epigenetic Mechanisms in SAMP8 Mouse Hippocampus by Reducing Oxidative Stress and Inflammaging and Achieving Neuroprotection.
PMID:27803663
The role of hydrogen sulfide in aging and age-related pathologies.
PMID:27683311
Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms.
PMID:27654999
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.
PMID:27511193
Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex.
PMID:27242522
The landscape of DNA methylation amid a perfect storm of autism aetiologies.
PMID:27150399
CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer's disease.
PMID:27094739
Age-related changes in Egr1 transcription and DNA methylation within the hippocampus.
PMID:26972614
The identification of age-associated cancer markers by an integrative analysis of dynamic DNA methylation changes.
PMID:26949191
Epigenetic modification of PKMζ rescues aging-related cognitive impairment.
PMID:26926225
Cellular Senescence as the Causal Nexus of Aging.
PMID:26904101
Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model.
PMID:26861500
Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study.
PMID:26861258
Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum.
PMID:26830004
Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease.
PMID:26803900
Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment.
PMID:26742120
Epigenetic Alterations in Alzheimer's Disease.
PMID:26734709
Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models.
PMID:26697081
Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders.
PMID:26689571
Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling.
PMID:26673150
The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter.
PMID:26481318
The APOE Gene is Differentially Methylated in Alzheimer's Disease.
PMID:26402071
Change in Epigenome-Wide DNA Methylation Over 9 Years and Subsequent Mortality: Results From the InCHIANTI Study.
PMID:26355017
DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women.
PMID:26175754
Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues.
PMID:26137924
2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.
PMID:26118662
Impacts of Chromatin States and Long-Range Genomic Segments on Aging and DNA Methylation.
PMID:26091484
The epigenetics of aging and neurodegeneration.
PMID:26072273
Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies.
PMID:26003740
The cerebellum ages slowly according to the epigenetic clock.
PMID:26000617
Transcriptomic profiles of aging in purified human immune cells.
PMID:25898983
Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes.
PMID:25880792
Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes.
PMID:25874017
DNA methylation dynamics in muscle development and disease.
PMID:25798107
Epigenetic mechanisms in neurological and neurodegenerative diseases.
PMID:25774124
Use of epigenetic drugs in disease: an overview.
PMID:25512710
Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth.
PMID:25437055
The future of neuroepigenetics in the human brain.
PMID:25410546
Age-related variations in the methylome associated with gene expression in human monocytes and T cells.
PMID:25404168
Exploring the epigenetics of Alzheimer disease.
PMID:25365705
Increased DNA methylation in the suicide brain.
PMID:25364291
A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.
PMID:25362550
Obesity accelerates epigenetic aging of human liver.
PMID:25313081
H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells.
PMID:25271306
Epigenetic contributions to cognitive aging: disentangling mindspan and lifespan.
PMID:25227252
Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease.
PMID:25201696
The epigenetic landscape of Alzheimer's disease.
PMID:25157507
Regulation of histone H3K4 methylation in brain development and disease.
PMID:25135975
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.
PMID:25129075
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
PMID:25064009
Epigenomics of Alzheimer's disease.
PMID:24905038
Gender-specific DNA methylome analysis of a Han Chinese longevity population.
PMID:24822201
Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs.
PMID:24789080
Grand-paternal age and the development of autism-like symptoms in mice progeny.
PMID:24780920
An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy.
PMID:24603599
Genome-wide methylation analyses in glioblastoma multiforme.
PMID:24586730
Aging and epigenetic drift: a vicious cycle.
PMID:24382386
Genome-wide DNA methylation changes with age in disease-free human skeletal muscle.
PMID:24304487
Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer.
PMID:24287154
Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains.
PMID:24270187
Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites.
PMID:24163245
DNA methylation age of human tissues and cell types.
PMID:24138928
Genetic effects on DNA methylation and its potential relevance for obesity in Mexican Americans.
PMID:24058506
Epigenetic studies in Alzheimer's disease: current findings, caveats, and considerations for future studies.
PMID:24038819
Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape.
PMID:24034465
DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease.
PMID:24030951
Epigenetic landscape of Parkinson's disease: emerging role in disease mechanisms and therapeutic modalities.
PMID:24030213
Epigenetic alterations by NuRD and PRC2 in the neonatal mouse cochlea.
PMID:23911933
Testing two models describing how methylome-wide studies in blood are informative for psychiatric conditions.
PMID:23895651
Chromatin-bound RNA and the neurobiology of psychiatric disease.
PMID:23831425
Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan.
PMID:23826282
Characterizing genes with distinct methylation patterns in the context of protein-protein interaction network: application to human brain tissues.
PMID:23776563
Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging.
PMID:23736955
Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance.
PMID:23697701
Age-specific signatures of glioblastoma at the genomic, genetic, and epigenetic levels.
PMID:23658659
Systems biology in aging: linking the old and the young.
PMID:23633915
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
PMID:23583978
Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.
PMID:23582657
Epigenetic determinants of healthy and diseased brain aging and cognition.
PMID:23571692
Eyes on DNA methylation: current evidence for DNA methylation in ocular development and disease.
PMID:23538551
Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges.
PMID:23423909
Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.
PMID:23360175
Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease.
PMID:23307060
Perinatal epigenetic determinants of cognitive and metabolic disorders.
PMID:23251850
DNA methylation in schizophrenia: progress and challenges of epigenetic studies.
PMID:23234572
Aging and reprogramming: a two-way street.
PMID:23146768
Epigenetic genome-wide association methylation in aging and longevity.
PMID:23130832
Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum.
PMID:23042784
Age-associated hyper-methylated regions in the human brain overlap with bivalent chromatin domains.
PMID:23028473
Measurements of DNA methylation at seven loci in various tissues of CD1 mice.
PMID:22970256
Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans.
PMID:22968814
The dynamics of DNA methylation in schizophrenia and related psychiatric disorders.
PMID:22948975
Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution.
PMID:22922032
Epigenetic mechanisms in neurological disease.
PMID:22869198
Characterization of CpG island DNA methylation of impairment-related genes in a rat model of cognitive aging.
PMID:22869088
Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders.
PMID:22832356
Epigenetic mechanisms governing the process of neurodegeneration.
PMID:22782013
Use of next-generation sequencing and other whole-genome strategies to dissect neurological disease.
PMID:22714018
An integrated approach to design novel therapeutic interventions for demyelinating disorders.
PMID:22708599
The secret language of destiny: stress imprinting and transgenerational origins of disease.
PMID:22675331
Epigenetics in the human brain.
PMID:22643929
Plasticity of DNA methylation in mouse T cell activation and differentiation.
PMID:22642378
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.
PMID:22532803
Targeting epigenetic mediators of gene expression in thoracic malignancies.
PMID:22507242
Choline nutrition programs brain development via DNA and histone methylation.
PMID:22483275
Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex.
PMID:22451312
Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.
PMID:22445327
Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus.
PMID:22426040
Global LINE-1 DNA methylation is associated with blood glycaemic and lipid profiles.
PMID:22422454
Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease.
PMID:22422451
Hot topics in epigenetic mechanisms of aging: 2011.
PMID:22321768
DNA methylation signatures in development and aging of the human prefrontal cortex.
PMID:22305529
MethylomeDB: a database of DNA methylation profiles of the brain.
PMID:22140101
Using DNA methylation to understand biological consequences of genetic variability.
PMID:22123027
Promoter methylation and age-related downregulation of Klotho in rhesus monkey.
PMID:21922250
Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction.
PMID:21764481
Epigenetics of early child development.
PMID:21647402
DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer.
PMID:21521786