R3J05N last accessed: 2022-11-04

Kinetoplastid genome resources (TritryPDB)
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:01.651645

tritrypdb
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:01.651645

Other names: kinetoplastid genomics resource, Kinetoplastid genome resources (TritryPDB), tritrypdb

TriTrypDB is one of the databases that can be accessed through the VEuPathDB portal, covering eukaryotic pathogens of the genera Cryptosporidium, Giardia, Leishmania, Neospora, Plasmodium, Toxoplasma, Trichomonas and Trypanosoma. While each of these groups is supported by a taxon-specific database built upon the same infrastructure, the VEuPathDB portal offers an entry point to all these resources, and the opportunity to leverage orthology for searches across genera.

Webpage:

http://tritrypdb.org/tritrypdb/

Licence:

Name: VEuPathDB Data Submission and Release Policies
URL: https://static-content.veupathdb.org/documents/VEuPathDB_Data_Sub_Release_policy_rev_02April2020.pdf

Publications:

Publications
More detailed information about this field from each metasource.

TriTrypDB: a functional genomic resource for the Trypanosomatidae
PMID: 19843604
metasource: Fairsharing.org
version: FAIRsharing.org: TriTrypDB; TriTrypDB; DOI: https://doi.org/10.25504/FAIRsharing.fs1z27; Last edited: Feb. 24, 2021, 4:42 p.m.; Last accessed: Jan 03 2022 7:07 p.m.

metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:01.651645

http://nar.oxfordjournals.org/content/38/suppl_1/D457
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

TriTrypDB: a functional genomic resource for the Trypanosomatidae PubMed citations: 477.

477 articles citing: TriTrypDB: a functional genomic resource for the Trypanosomatidae

Discovery of Leishmania Druggable Serine Proteases by Activity-Based Protein Profiling. PMID:35910377
The Use of AlphaFold for In Silico Exploration of Drug Targets in the Parasite Trypanosoma cruzi. PMID:35909956
Nucleoside Transport and Nucleobase Uptake Null Mutants in Leishmania mexicana for the Routine Expression and Characterization of Purine and Pyrimidine Transporters. PMID:35897714
Current Status of Regulatory Non-Coding RNAs Research in the Tritryp. PMID:35893237
Stable Episomal Transfectant Leishmania infantum Promastigotes Over-Expressing the DEVH1 RNA Helicase Gene Down-Regulate Parasite Survival Genes. PMID:35890006
Differences in Charge Distribution in Leishmania tarentolae Leishmanolysin Result in a Reduced Enzymatic Activity. PMID:35887004
Stage-specific transcription activator ESB1 regulates monoallelic antigen expression in Trypanosoma brucei. PMID:35879525
The Kinetoplastid-Specific Protein TcCAL1 Plays Different Roles During In Vitro Differentiation and Host-Cell Invasion in Trypanosoma cruzi. PMID:35846750
Evolutionary analysis of globin domains from kinetoplastids. PMID:35841431
Replacement of Leishmania (Leishmania) infantum Populations in an Endemic Focus of Visceral Leishmaniasis in Brazil. PMID:35811682
Expression Profile of Genes Related to the Th17 Pathway in Macrophages Infected by Leishmania major and Leishmania amazonensis: The Use of Gene Regulatory Networks in Modeling This Pathway. PMID:35774406
Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: Phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content. PMID:35749562
Assembly of a Large Collection of Maxicircle Sequences and Their Usefulness for Leishmania Taxonomy and Strain Typing. PMID:35741832
Paving the Way: Contributions of Big Data to Apicomplexan and Kinetoplastid Research. PMID:35734575
A long noncoding RNA promotes parasite differentiation in African trypanosomes. PMID:35704590
A novel SNF2 ATPase complex in Trypanosoma brucei with a role in H2A.Z-mediated chromatin remodelling. PMID:35675371
Trypanosoma cruzi iron superoxide dismutases: insights from phylogenetics to chemotherapeutic target assessment. PMID:35668508
Polyamine Metabolism in Leishmania Parasites: A Promising Therapeutic Target. PMID:35645240
Consensus Enolase of Trypanosoma Cruzi: Evaluation of Their Immunogenic Properties Using a Bioinformatics Approach. PMID:35629412
Comparative Sensitivity and Specificity of the 7SL sRNA Diagnostic Test for Animal Trypanosomiasis. PMID:35450136
Tissue Specific Dual RNA-Seq Defines Host-Parasite Interplay in Murine Visceral Leishmaniasis Caused by Leishmania donovani and Leishmania infantum. PMID:35384718
The genomic basis of host and vector specificity in non-pathogenic trypanosomatids. PMID:35373253
Visualisation of proteome-wide ordered protein abundances in Trypanosoma brucei. PMID:35284642
Visualisation of experimentally determined and predicted protein N-glycosylation and predicted glycosylphosphatidylinositol anchor addition in Trypanosoma brucei. PMID:35284639
TbKINX1B: a novel BILBO1 partner and an essential protein in bloodstream form Trypanosoma brucei. PMID:35262485
Targeted Deletion of Centrin in Leishmania braziliensis Using CRISPR-Cas9-Based Editing. PMID:35252020
Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis. PMID:35236861
STopTox: An in Silico Alternative to Animal Testing for Acute Systemic and Topical Toxicity. PMID:35192406
Transcriptomic Profile of Canine DH82 Macrophages Infected by Leishmania infantum Promastigotes with Different Virulence Behavior. PMID:35163386
Impact of Genetic Diversity and Genome Plasticity of Leishmania spp. in Treatment and the Search for Novel Chemotherapeutic Targets. PMID:35141175
Transcriptome-Wide Identification of Coding and Noncoding RNA-Binding Proteins Defines the Comprehensive RNA Interactome of Leishmania mexicana. PMID:35138191
Plasticity in centromere organization and kinetochore composition: Lessons from diversity. PMID:35108654
Proteomics Uncovers Novel Components of an Interactive Protein Network Supporting RNA Export in Trypanosomes. PMID:35091090
LncRNAs Are Differentially Expressed between Wildtype and Cell Line Strains of African Trypanosomes. PMID:35076577
Facing Diseases Caused by Trypanosomatid Parasites: Rational Design of Pd and Pt Complexes With Bioactive Ligands. PMID:35071192
The Importance of Glycerophospholipid Production to the Mutualist Symbiosis of Trypanosomatids. PMID:35055989
A profile of research on the parasitic trypanosomatids and the diseases they cause. PMID:35025891
Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana. PMID:34965251
A novel leishmanial copper P-type ATPase plays a vital role in parasite infection and intracellular survival. PMID:34958799
High throughput single-cell genome sequencing gives insights into the generation and evolution of mosaic aneuploidy in Leishmania donovani. PMID:34893872
Characterization of an Atypical eIF4E Ortholog in Leishmania, LeishIF4E-6. PMID:34884522
A distinct complex of PRP19-related and trypanosomatid-specific proteins is required for pre-mRNA splicing in trypanosomes. PMID:34850936
Analyses of Leishmania-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins. PMID:34835111
In Leishmania major, the Homolog of the Oncogene PES1 May Play a Critical Role in Parasite Infectivity. PMID:34830469
A resource for improved predictions of Trypanosoma and Leishmania protein three-dimensional structure. PMID:34762696
Metacyclogenesis defects and gene expression hallmarks of histone deacetylase 4-deficient Trypanosoma cruzi cells. PMID:34737385
Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection. PMID:34714824
Variation in Leishmania chemokine suppression driven by diversification of the GP63 virulence factor. PMID:34710089
Prevalence and Molecular Identification of Trypanosomes in Dogs in Enugu North Senatorial Zone, South East Nigeria. PMID:34625859
In Vivo Structure-Function Analysis and Redox Interactomes of Leishmania tarentolae Erv. PMID:34585988
In Silico Characterization of Calcineurin from Pathogenic Obligate Intracellular Trypanosomatids: Potential New Biological Roles. PMID:34572535
Allele-specific assembly of a eukaryotic genome corrects apparent frameshifts and reveals a lack of nonsense-mediated mRNA decay. PMID:34541528
The nucleolar DExD/H protein Hel66 is involved in ribosome biogenesis in Trypanosoma brucei. PMID:34526538
Trypanosoma brucei triggers a broad immune response in the adipose tissue. PMID:34525131
Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae. PMID:34489462
Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing. PMID:34489460
Expansion microscopy facilitates quantitative super-resolution studies of cytoskeletal structures in kinetoplastid parasites. PMID:34465213
Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan. PMID:34454601
Experimental Selection of Paromomycin Resistance in Leishmania donovani Amastigotes Induces Variable Genomic Polymorphisms. PMID:34442625
Development of a chimeric protein based on a proteomic approach for the serological diagnosis of human tegumentary leishmaniasis. PMID:34432132
Cytosolic and Mitochondrial Hsp90 in Cytokinesis, Mitochondrial DNA Replication, and Drug Action in Trypanosoma brucei. PMID:34424040
Comparative analysis of the transcriptional responses of five Leishmania species to trivalent antimony. PMID:34419127
An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei. PMID:34410224
AQPX-cluster aquaporins and aquaglyceroporins are asymmetrically distributed in trypanosomes. PMID:34376792
Novel Purine Chemotypes with Activity against Plasmodium falciparum and Trypanosoma cruzi. PMID:34358064
Structural and functional studies of the first tripartite protein complex at the Trypanosoma brucei flagellar pocket collar. PMID:34339455
Automated Phylogenetic Analysis Using Best Reciprocal BLAST. PMID:34313983
Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition. PMID:34310651
LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline. PMID:34292068
Life Cycle Stage-Specific Accessibility of Leishmania donovani Chromatin at Transcription Start Regions. PMID:34282941
Evolution and diversification of the nuclear pore complex. PMID:34282823
Polysomal mRNA Association and Gene Expression in Trypanosoma brucei. PMID:34250262
Preferential import of queuosine-modified tRNAs into Trypanosoma brucei mitochondrion is critical for organellar protein synthesis. PMID:34244755
Is mRNA decapping by ApaH like phosphatases present in eukaryotes beyond the Kinetoplastida? PMID:34162332
Novel aspects of iron homeostasis in pathogenic bloodstream form Trypanosoma brucei. PMID:34161395
A hub-and-spoke nuclear lamina architecture in trypanosomes. PMID:34151975
Selective nuclear export of mRNAs is promoted by DRBD18 in Trypanosoma brucei. PMID:34146438
Kinetoplastid kinetochore proteins KKT2 and KKT3 have unique centromere localization domains. PMID:34081090
DNA Topoisomerase 3α Is Involved in Homologous Recombination Repair and Replication Stress Response in Trypanosoma cruzi. PMID:34055812
An invariant Trypanosoma vivax vaccine antigen induces protective immunity. PMID:34040257
The Trypanosoma brucei subpellicular microtubule array is organized into functionally discrete subdomains defined by microtubule associated proteins. PMID:34010336
Structural studies of the shortest extended synaptotagmin with only two C2 domains from Trypanosoma brucei. PMID:33997700
Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery. PMID:33987166
Quantitative Proteomics Reveals that Hsp90 Inhibition Dynamically Regulates Global Protein Synthesis in Leishmania mexicana. PMID:33975965
Protein Serine/Threonine Phosphatase Type 2C of Leishmania mexicana. PMID:33937094
LeishIF4E-5 Is a Promastigote-Specific Cap-Binding Protein in Leishmania. PMID:33921489
Structural characterization of KKT4, an unconventional microtubule-binding kinetochore protein. PMID:33915106
Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion. PMID:33869086
Casein kinase TbCK1.2 regulates division of kinetoplast DNA, and movement of basal bodies in the African trypanosome. PMID:33861760
HLA-DRB1 Alleles Associated with Lower Leishmaniasis Susceptibility Share Common Amino Acid Polymorphisms and Epitope Binding Repertoires. PMID:33803005
Distinct features of the Leishmania cap-binding protein LeishIF4E2 revealed by CRISPR-Cas9 mediated hemizygous deletion. PMID:33760809
Nutrient availability regulates proline/alanine transporters in Trypanosoma brucei. PMID:33745971
Proteomic identification of the UDP-GlcNAc: PI α1-6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei. PMID:33735232
Catalase impairs Leishmania mexicana development and virulence. PMID:33724149
Deletion of a Golgi protein in Trypanosoma cruzi reveals a critical role for Mn2+ in protein glycosylation needed for host cell invasion and intracellular replication. PMID:33720977
PhyloQuant approach provides insights into Trypanosoma cruzi evolution using a systems-wide mass spectrometry-based quantitative protein profile. PMID:33707618
Evidence that a naturally occurring single nucleotide polymorphism in the RagC gene of Leishmania donovani contributes to reduced virulence. PMID:33621241
Diverse telomeres in trypanosomatids. PMID:33612129
Nucleotide sugar biosynthesis occurs in the glycosomes of procyclic and bloodstream form Trypanosoma brucei. PMID:33592041
Characterization of the novel mitochondrial genome segregation factor TAP110 in Trypanosoma brucei. PMID:33589495
Physiological and proteomic profiles of Trypanosoma brucei rhodesiense parasite isolated from suramin responsive and non-responsive HAT patients in Busoga, Uganda. PMID:33588295
APEX2 Proximity Proteomics Resolves Flagellum Subdomains and Identifies Flagellum Tip-Specific Proteins in Trypanosoma brucei. PMID:33568455
The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast. PMID:33535521
In silico and in vitro Evaluation of Mimetic Peptides as Potential Antigen Candidates for Prophylaxis of Leishmaniosis. PMID:33520931
Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease. PMID:33508020
Gene co-expression network analysis of Trypanosoma brucei in tsetse fly vector. PMID:33482903
Nuclear mRNA maturation and mRNA export control: from trypanosomes to opisthokonts. PMID:33461637
Anti-Trypanosoma cruzi Activity of Metabolism Modifier Compounds. PMID:33445756
Evolution and diversification of the nuclear envelope. PMID:33435791
Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes. PMID:33432154
Characterization of a new Leishmania major strain for use in a controlled human infection model. PMID:33431825
Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system. PMID:33429173
Differences in mitochondrial NADH dehydrogenase activities in trypanosomatids. PMID:33407966
Rapid protein evolution, organellar reductions, and invasive intronic elements in the marine aerobic parasite dinoflagellate Amoebophrya spp. PMID:33407428
Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea. PMID:33234025
Analysis of DNA Polymerases Reveals Specific Genes Expansion in Leishmania and Trypanosoma spp. PMID:33117729
Differentially modulated proteins associated with Leishmaniasis-a systematic review of in-vivo and in-vitro studies. PMID:33113081
Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex. PMID:33108402
Identification of Novel Interspersed DNA Repetitive Elements in the Trypanosoma cruzi Genome Associated with the 3'UTRs of Surface Multigenic Families. PMID:33096822
OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines. PMID:33084874
Analysis of the IGS rRNA Region and Applicability for Leishmania (V.) braziliensis Characterization. PMID:33083046
Study of the differentially abundant proteins among Leishmania amazonensis, L. braziliensis, and L. infantum. PMID:33057350
Phylogenomics from transcriptomic "bycatch" clarify the origins and diversity of avian trypanosomes in North America. PMID:33031471
Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi. PMID:33021977
Nuclear and mitochondrial genome sequencing of North-African Leishmania infantum isolates from cured and relapsed visceral leishmaniasis patients reveals variations correlating with geography and phenotype. PMID:32975503
Comparative Analysis of the Secretome and Interactome of Trypanosoma cruzi and Trypanosoma rangeli Reveals Species Specific Immune Response Modulating Proteins. PMID:32973747
Expanded genome-wide comparisons give novel insights into population structure and genetic heterogeneity of Leishmania tropica complex. PMID:32946436
Leishmania infantum infection in a dog imported from Morocco. PMID:32879521
Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance. PMID:32837530
The Absence of C-5 DNA Methylation in Leishmania donovani Allows DNA Enrichment from Complex Samples. PMID:32824654
Design of a AFLP-PCR and PCR-RFLP test that identify the majority of discrete typing units of Trypanosoma cruzi. PMID:32750094
The Immunoglobulin M-Shed Acute Phase Antigen (SAPA)-test for the Early Diagnosis of Congenital Chagas Disease in the Time of the Elimination Goal of Mother-to-Child Transmission. PMID:32667981
A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing. PMID:32651371
Unravelling the proteomic signature of extracellular vesicles released by drug-resistant Leishmania infantum parasites. PMID:32628683
MRPA-independent mechanisms of antimony resistance in Leishmania infantum. PMID:32413766
GCN2-Like Kinase Modulates Stress Granule Formation During Nutritional Stress in Trypanosoma cruzi. PMID:32373547
PRMT7 regulates RNA-binding capacity and protein stability in Leishmania parasites. PMID:32365184
Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes. PMID:32354742
Regulation of Translation in the Protozoan Parasite Leishmania. PMID:32340274
Control of assembly of extra-axonemal structures: the paraflagellar rod of trypanosomes. PMID:32295845
A Global Analysis of Enzyme Compartmentalization to Glycosomes. PMID:32290588
Molecular Characterization of Tc964, A Novel Antigenic Protein from Trypanosoma cruzi. PMID:32244527
An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei. PMID:32213288
Global genome diversity of the Leishmania donovani complex. PMID:32209228
Design of an Epitope-Based Vaccine Ensemble for Animal Trypanosomiasis by Computational Methods. PMID:32188062
A Uniquely Complex Mitochondrial Proteome from Euglena gracilis. PMID:32159766
Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru. PMID:32150562
Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions. PMID:32102938
Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes. PMID:32084124
A DNA polymerization-independent role for mitochondrial DNA polymerase I-like protein C in African trypanosomes. PMID:32079654
Rapid block of pre-mRNA splicing by chemical inhibition of analog-sensitive CRK9 in Trypanosoma brucei. PMID:32068297
A Novel Calcium-Activated Potassium Channel Controls Membrane Potential and Intracellular pH in Trypanosoma cruzi. PMID:32010643
Proteins involved in the biosynthesis of lipophosphoglycan in Leishmania: a comparative genomic and evolutionary analysis. PMID:32000835
Single-cell RNA sequencing of Trypanosoma brucei from tsetse salivary glands unveils metacyclogenesis and identifies potential transmission blocking antigens. PMID:31964820
Gene expression profiling of Trypanosoma cruzi in the presence of heme points to glycosomal metabolic adaptation of epimastigotes inside the vector. PMID:31895927
A BONCAT-iTRAQ method enables temporally resolved quantitative profiling of newly synthesised proteins in Leishmania mexicana parasites during starvation. PMID:31856154
Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway. PMID:31848371
Organising the cell cycle in the absence of transcriptional control: Dynamic phosphorylation co-ordinates the Trypanosoma brucei cell cycle post-transcriptionally. PMID:31830130
In silico Design of an Epitope-Based Vaccine Ensemble for Chagas Disease. PMID:31824493
Identification of four unconventional kinetoplastid kinetochore proteins KKT22-25 in Trypanosoma brucei. PMID:31795916
P-type transport ATPases in Leishmania and Trypanosoma. PMID:31782726
LmxM.22.0250-Encoded Dual Specificity Protein/Lipid Phosphatase Impairs Leishmania mexicana Virulence In Vitro. PMID:31744234
Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal Protein, Result in Asthenozoospermia and Male Infertility. PMID:31735292
LeishIF4E1 Deletion Affects the Promastigote Proteome, Morphology, and Infectivity. PMID:31722993
The Novel Serine/Threonine Protein Kinase LmjF.22.0810 from Leishmania major may be Involved in the Resistance to Drugs such as Paromomycin. PMID:31718000
Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania. PMID:31710597
Telomere and Subtelomere R-loops and Antigenic Variation in Trypanosomes. PMID:31682833
Proteome turnover in the bloodstream and procyclic forms of Trypanosoma brucei measured by quantitative proteomics. PMID:31681858
Comparative genomics of Leishmania (Mundinia). PMID:31601168
More than Microtubules: The Structure and Function of the Subpellicular Array in Trypanosomatids. PMID:31471215
Efficient and specific oligo-based depletion of rRNA. PMID:31439880
The general mRNA exporters Mex67 and Mtr2 play distinct roles in nuclear export of tRNAs in Trypanosoma brucei. PMID:31392978
Study of VIPER and TATE in kinetoplastids and the evolution of tyrosine recombinase retrotransposons. PMID:31391870
Identifying miltefosine-resistant key genes in protein-protein interactions network and experimental verification in Iranian Leishmania major. PMID:31385238
Dramatic changes in gene expression in different forms of Crithidia fasciculata reveal potential mechanisms for insect-specific adhesion in kinetoplastid parasites. PMID:31356610
Leishmania tarentolae: Taxonomic classification and its application as a promising biotechnological expression host. PMID:31344033
Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections. PMID:31242261
MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca2+ Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi. PMID:31064825
Mapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC-MS. PMID:31028136
Complete assembly of the Leishmania donovani (HU3 strain) genome and transcriptome annotation. PMID:30992521
Leishmania-Host Interactions-An Epigenetic Paradigm. PMID:30967861
Conserved motifs in nuclear genes encoding predicted mitochondrial proteins in Trypanosoma cruzi. PMID:30964924
Unveiling the Kinomes of Leishmania infantum and L. braziliensis Empowers the Discovery of New Kinase Targets and Antileishmanial Compounds. PMID:30949306
The mRNA-bound Proteome of Leishmania mexicana: Novel Genetic Insight into an Ancient Parasite. PMID:30948621
Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections. PMID:30943202
Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly. PMID:30940671
Nutritional stress targets LeishIF4E-3 to storage granules that contain RNA and ribosome components in Leishmania. PMID:30870425
Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake. PMID:30850347
Basalin is an evolutionarily unconstrained protein revealed via a conserved role in flagellum basal plate function. PMID:30810527
Parasite specific 7SL-derived small RNA is an effective target for diagnosis of active trypanosomiasis infection. PMID:30779758
Transcriptome, proteome and draft genome of Euglena gracilis. PMID:30732613
Comparative transcriptomics in Leishmania braziliensis: disclosing differential gene expression of coding and putative noncoding RNAs across developmental stages. PMID:30689499
A tRNA half modulates translation as stress response in Trypanosoma brucei. PMID:30631057
Small nucleolar RNAs controlling rRNA processing in Trypanosoma brucei. PMID:30605535
New antigens for the serological diagnosis of human visceral leishmaniasis identified by immunogenomic screening. PMID:30571783
Cellular landmarks of Trypanosoma brucei and Leishmania mexicana. PMID:30550896
Draft Whole-Genome Sequence of Leishmania (Viannia) braziliensis Presenting Leishmania RNA Virus 1, from Western Amazon, Brazil. PMID:30533928
The Hsp70/J-protein machinery of the African trypanosome, Trypanosoma brucei. PMID:30506377
Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing. PMID:30503212
Genomic insights into virulence mechanisms of Leishmania donovani: evidence from an atypical strain. PMID:30486770
A real-time PCR assay for quantification of parasite burden in murine models of leishmaniasis. PMID:30430041
Whole genome sequencing of Trypanosoma cruzi field isolates reveals extensive genomic variability and complex aneuploidy patterns within TcII DTU. PMID:30424726
Trypanosomes can initiate nuclear export co-transcriptionally. PMID:30418648
A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence. PMID:30409989
A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei. PMID:30365568
VianniaTopes: a database of predicted immunogenic peptides for Leishmania (Viannia) species. PMID:30358842
Genomic comparison of Trypanosoma conorhini and Trypanosoma rangeli to Trypanosoma cruzi strains of high and low virulence. PMID:30355302
Branched late-steps of the cytosolic iron-sulphur cluster assembly machinery of Trypanosoma brucei. PMID:30346997
Polyamines in protozoan pathogens. PMID:30333232
5-Diphosphoinositol pentakisphosphate (5-IP7) regulates phosphate release from acidocalcisomes and yeast vacuoles. PMID:30315104
TbUTP10, a protein involved in early stages of pre-18S rRNA processing in Trypanosoma brucei. PMID:30248370
Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of Trypanosoma cruzi. PMID:30232153
Inorganic polyphosphate interacts with nucleolar and glycosomal proteins in trypanosomatids. PMID:30230089
Insights on a putative aminoacyl-tRNA-protein transferase of Leishmania major. PMID:30208112
Resistance of Leishmania infantum to allopurinol is associated with chromosome and gene copy number variations including decrease in the S-adenosylmethionine synthetase (METK) gene copy number. PMID:30173105
Assessing the partners of the RBP9-mRNP complex in Trypanosoma cruzi using shotgun proteomics and RNA-seq. PMID:30146924
Pathogen Species Identification from Metagenomes in Ancient Remains: The Challenge of Identifying Human Pathogenic Species of Trypanosomatidae via Bioinformatic Tools. PMID:30127280
A Homozygous Ancestral SVA-Insertion-Mediated Deletion in WDR66 Induces Multiple Morphological Abnormalities of the Sperm Flagellum and Male Infertility. PMID:30122540
The unusual flagellar-targeting mechanism and functions of the trypanosome ortholog of the ciliary GTPase Arl13b. PMID:30097558
Life cycle adapted upstream open reading frames (uORFs) in Trypanosoma congolense: A post-transcriptional approach to accurate gene regulation. PMID:30092050
Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNA. PMID:30040867
The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei. PMID:30040830
Evolutionary Perspectives of Genotype-Phenotype Factors in Leishmania Metabolism. PMID:30022295
Amino acid permease 3 (aap3) coding sequence as a target for Leishmania identification and diagnosis of leishmaniases using high resolution melting analysis. PMID:30012182
Identification and Characterization of a Novel Palmitoyl Acyltransferase as a Druggable Rheostat of Dynamic Palmitoylome in L. donovani. PMID:29977865
Expression profiling of Trypanosoma congolense genes during development in the tsetse fly vector Glossina morsitans morsitans. PMID:29970164
Leishmania donovani Parasites Are Inhibited by the Benzoxaborole AN2690 Targeting Leucyl-tRNA Synthetase. PMID:29941647
A MFS-like plasma membrane transporter required for Leishmania virulence protects the parasites from iron toxicity. PMID:29906288
Genetic manipulation of Leishmania donovani threonyl tRNA synthetase facilitates its exploration as a potential therapeutic target. PMID:29897900
Identification of TOEFAZ1-interacting proteins reveals key regulators of Trypanosoma brucei cytokinesis. PMID:29781112
Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PMID:29758036
The protein family TcTASV-C is a novel Trypanosoma cruzi virulence factor secreted in extracellular vesicles by trypomastigotes and highly expressed in bloodstream forms. PMID:29727453
Distinct 3' UTRs regulate the life-cycle-specific expression of two TCTP paralogs in Trypanosoma brucei. PMID:29661850
Characterization of the novel mitochondrial genome replication factor MiRF172 in Trypanosoma brucei. PMID:29626111
Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping. PMID:29608569
High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms. PMID:29602064
Lipophosphoglycan 3 From Leishmania infantum chagasi Binds Heparin With Micromolar Affinity. PMID:29568220
Proteomic Analysis of the Cell Cycle of Procylic Form Trypanosoma brucei. PMID:29555687
UDP-glycosyltransferase genes in trypanosomatid genomes have diversified independently to meet the distinct developmental needs of parasite adaptations. PMID:29540192
Building protein-protein interaction networks for Leishmania species through protein structural information. PMID:29510668
SUMO polymeric chains are involved in nuclear foci formation and chromatin organization in Trypanosoma brucei procyclic forms. PMID:29474435
Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human. PMID:29449551
Assembly of highly repetitive genomes using short reads: the genome of discrete typing unit III Trypanosoma cruzi strain 231. PMID:29442617
CRISPR/Cas9 in Leishmania mexicana: A case study of LmxBTN1. PMID:29438445
Molecular model of the mitochondrial genome segregation machinery in Trypanosoma brucei. PMID:29434039
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles. PMID:29425238
Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization. PMID:29358582
Characterisation of Casein Kinase 1.1 in Leishmania donovani Using the CRISPR Cas9 Toolkit. PMID:29333442
Function of Macrophage and Parasite Phosphatases in Leishmaniasis. PMID:29312331
The genomes of Crithidia bombi and C. expoeki, common parasites of bumblebees. PMID:29304093
Trypanosoma brucei EIF4E2 cap-binding protein binds a homolog of the histone-mRNA stem-loop-binding protein. PMID:29288414
Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection. PMID:29240831
Trypanosomatid mitochondrial RNA editing: dramatically complex transcript repertoires revealed with a dedicated mapping tool. PMID:29220521
LeishDB: a database of coding gene annotation and non-coding RNAs in Leishmania braziliensis. PMID:29220437
Transcriptome-wide analysis of the Trypanosoma cruzi proliferative cycle identifies the periodically expressed mRNAs and their multiple levels of control. PMID:29182646
TbSmee1 regulates hook complex morphology and the rate of flagellar pocket uptake in Trypanosoma brucei. PMID:29178204
Molecular characterization of tsetse's proboscis and its response to Trypanosoma congolense infection. PMID:29155830
Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin. PMID:29150609
Prediction of Protein Complexes in Trypanosoma brucei by Protein Correlation Profiling Mass Spectrometry and Machine Learning. PMID:29042480
STRIDE: Species Tree Root Inference from Gene Duplication Events. PMID:29029342
A functional analysis of TOEFAZ1 uncovers protein domains essential for cytokinesis in Trypanosoma brucei. PMID:28993462
Next-generation ELISA diagnostic assay for Chagas Disease based on the combination of short peptidic epitopes. PMID:28991925
High-resolution profiling of linear B-cell epitopes from mucin-associated surface proteins (MASPs) of Trypanosoma cruzi during human infections. PMID:28961244
Cell cycle stage-specific transcriptional activation of cyclins mediated by HAT2-dependent H4K10 acetylation of promoters in Leishmania donovani. PMID:28938001
Identification of the centromeres of Leishmania major: revealing the hidden pieces. PMID:28935715
Single-subunit oligosaccharyltransferases of Trypanosoma brucei display different and predictable peptide acceptor specificities. PMID:28928222
Cell Cycle Inhibition To Treat Sleeping Sickness. PMID:28928213
Genome sequencing reveals metabolic and cellular interdependence in an amoeba-kinetoplastid symbiosis. PMID:28916813
Structural basis for the high specificity of a Trypanosoma congolense immunoassay targeting glycosomal aldolase. PMID:28915239
Shape, form, function and Leishmania pathogenicity: from textbook descriptions to biological understanding. PMID:28903998
An Alternative Strategy for Trypanosome Survival in the Mammalian Bloodstream Revealed through Genome and Transcriptome Analysis of the Ubiquitous Bovine Parasite Trypanosoma (Megatrypanum) theileri. PMID:28903536
Genetic Validation of Leishmania donovani Lysyl-tRNA Synthetase Shows that It Is Indispensable for Parasite Growth and Infectivity. PMID:28875178
Interspecies quorum sensing in co-infections can manipulate trypanosome transmission potential. PMID:28871083
Disclosing 3' UTR cis-elements and putative partners involved in gene expression regulation in Leishmania spp. PMID:28859096
The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins. PMID:28837104
Transcriptional Profiling of Midguts Prepared from Trypanosoma/T. congolense-Positive Glossina palpalis palpalis Collected from Two Distinct Cameroonian Foci: Coordinated Signatures of the Midguts' Remodeling As T. congolense-Supportive Niches. PMID:28804485
In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease. PMID:28751689
A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts. PMID:28742133
The nuclear proteome of Trypanosoma brucei. PMID:28727848
A Computational Methodology to Overcome the Challenges Associated With the Search for Specific Enzyme Targets to Develop Drugs Against Leishmania major. PMID:28638238
The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes. PMID:28628654
Multiplexed Spliced-Leader Sequencing: A high-throughput, selective method for RNA-seq in Trypanosomatids. PMID:28623350
Comparative analyses of whole genome sequences of Leishmania infantum isolates from humans and dogs in northeastern Brazil. PMID:28606698
An essential domain of an early-diverged RNA polymerase II functions to accurately decode a primitive chromatin landscape. PMID:28575287
Characterization of the Protein Tyrosine Phosphatase LmPRL-1 Secreted by Leishmania major via the Exosome Pathway. PMID:28507071
The mitochondrial SIR2 related protein 2 (SIR2RP2) impacts Leishmania donovani growth and infectivity. PMID:28493888
Charting organellar importomes by quantitative mass spectrometry. PMID:28485388
Characterization of RBP9 and RBP10, two developmentally regulated RNA-binding proteins in Trypanosoma brucei. PMID:28381627
The Transcriptome of Leishmania major Developmental Stages in Their Natural Sand Fly Vector. PMID:28377524
Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. PMID:28328988
La Deletion from Mouse Brain Alters Pre-tRNA Metabolism and Accumulation of Pre-5.8S rRNA, with Neuron Death and Reactive Astrocytosis. PMID:28223366
The Evolutionary Loss of RNAi Key Determinants in Kinetoplastids as a Multiple Sporadic Phenomenon. PMID:28210761
Exo-miRExplorer: A Comprehensive Resource for Exploring and Comparatively Analyzing Exogenous MicroRNAs. PMID:28203233
Giant FAZ10 is required for flagellum attachment zone stabilization and furrow positioning in Trypanosoma brucei. PMID:28193733
Let's get fISSical: fast in silico synchronization as a new tool for cell division cycle analysis. PMID:28166845
TrypsNetDB: An integrated framework for the functional characterization of trypanosomatid proteins. PMID:28158179
The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis. PMID:28114397
In situ structure of trypanosomal ATP synthase dimer reveals a unique arrangement of catalytic subunits. PMID:28096380
Arginine and Lysine Transporters Are Essential for Trypanosoma brucei. PMID:28045943
The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins. PMID:27991487
Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms. PMID:27911896
Mining SNPs in extracellular vesicular transcriptome of Trypanosoma cruzi: a step closer to early diagnosis of neglected Chagas disease. PMID:27904804
Tsetse fly tolerance to T. brucei infection: transcriptome analysis of trypanosome-associated changes in the tsetse fly salivary gland. PMID:27884110
Novel Effects of Lapatinib Revealed in the African Trypanosome by Using Hypothesis-Generating Proteomics and Chemical Biology Strategies. PMID:27872081
TrypTag.org: A Trypanosome Genome-wide Protein Localisation Resource. PMID:27863903
Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model. PMID:27855164
Dietary nitrogen alters codon bias and genome composition in parasitic microorganisms. PMID:27842572
Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit. PMID:27791004
Two flagellar BAR domain proteins in Trypanosoma brucei with stage-specific regulation. PMID:27779220
Increased Abundance of Proteins Involved in Resistance to Oxidative and Nitrosative Stress at the Last Stages of Growth and Development of Leishmania amazonensis Promastigotes Revealed by Proteome Analysis. PMID:27776144
Identification of internalin-A-like virulent proteins in Leishmania donovani. PMID:27765050
Determination of the ribosome structure to a resolution of 2.5 Å by single-particle cryo-EM. PMID:27750394
Structural characterization reveals a novel bilobed architecture for the ectodomains of insect stage expressed Trypanosoma brucei PSSA-2 and Trypanosoma congolense ISA. PMID:27671214
Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression. PMID:27625397
Combination of In Silico Methods in the Search for Potential CD4(+) and CD8(+) T Cell Epitopes in the Proteome of Leishmania braziliensis. PMID:27621732
Characterization of a Novel Endoplasmic Reticulum Protein Involved in Tubercidin Resistance in Leishmania major. PMID:27606425
DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes. PMID:27540585
GMP reductase and genetic uncoupling of adenylate and guanylate metabolism in Leishmania donovani parasites. PMID:27343371
Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei. PMID:27331140
Heme pathway evolution in kinetoplastid protists. PMID:27193376
Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. PMID:27165796
Influence of the Microenvironment in the Transcriptome of Leishmania infantum Promastigotes: Sand Fly versus Culture. PMID:27163123
Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania. PMID:27162331
Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites. PMID:27133314
Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes. PMID:27123924
Genomic Appraisal of the Multifactorial Basis for In Vitro Acquisition of Miltefosine Resistance in Leishmania donovani. PMID:27114280
Illuminating Parasite Protein Production by Ribosome Profiling. PMID:27061497
Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. PMID:27021793
Resequencing and assembly of seven complex loci to improve the Leishmania major (Friedlin strain) reference genome. PMID:26857920
Whole genome sequencing shows sleeping sickness relapse is due to parasite regrowth and not reinfection. PMID:26834831
Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma brucei. PMID:26796527
Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications. PMID:26786754
The Trypanosoma cruzi Protein TcHTE Is Critical for Heme Uptake. PMID:26752206
Novel Characteristics of Trypanosoma brucei Guanosine 5'-monophosphate Reductase Distinct from Host Animals. PMID:26731263
The Dynamics of Lateral Gene Transfer in Genus Leishmania - A Route for Adaptation and Species Diversification. PMID:26730948
Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome. PMID:26684831
Transcriptional and phenotypical heterogeneity of Trypanosoma cruzi cell populations. PMID:26674416
A transcription-independent epigenetic mechanism is associated with antigenic switching in Trypanosoma brucei. PMID:26673706
Basal body multipotency and axonemal remodelling are two pathways to a 9+0 flagellum. PMID:26667778
Leishmania donovani Encodes a Functional Selenocysteinyl-tRNA Synthase. PMID:26586914
Identification of the nicotinamide mononucleotide adenylyltransferase of Trypanosoma cruzi. PMID:26560979
The Leishmania metaphylome: a comprehensive survey of Leishmania protein phylogenetic relationships. PMID:26518129
Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes. PMID:26492041
Molecular control of irreversible bistability during trypanosome developmental commitment. PMID:26483558
Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A. PMID:26459761
Three-dimensional structure model and predicted ATP interaction rewiring of a deviant RNA ligase 2. PMID:26449279
Targeting Lysine Deacetylases (KDACs) in Parasites. PMID:26402733
Trypanosoma cruzi Binds to Cytokeratin through Conserved Peptide Motifs Found in the Laminin-G-Like Domain of the gp85/Trans-sialidase Proteins. PMID:26398185
Differential Gene Expression and Infection Profiles of Cutaneous and Mucosal Leishmania braziliensis Isolates from the Same Patient. PMID:26366580
Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania donovani. PMID:26317207
Systems analysis of host-parasite interactions. PMID:26306749
Data in support of large scale comparative codon usage analysis in Leishmania and Trypanosomatids. PMID:26217801
Novel insights into RNP granules by employing the trypanosome's microtubule skeleton as a molecular sieve. PMID:26187993
A framework for ontology-based question answering with application to parasite immunology. PMID:26185615
Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease. PMID:26162928
An immunoinformatic approach for identification of Trypanosoma cruzi HLA-A2-restricted CD8(+) T cell epitopes. PMID:26107442
Databases for Microbiologists. PMID:26013493
A draft genome for the African crocodilian trypanosome Trypanosoma grayi. PMID:25977781
Towards High-throughput Immunomics for Infectious Diseases: Use of Next-generation Peptide Microarrays for Rapid Discovery and Mapping of Antigenic Determinants. PMID:25922409
In silico search of energy metabolism inhibitors for alternative leishmaniasis treatments. PMID:25918726
RNA interference screen reveals a high proportion of mitochondrial proteins essential for correct cell cycle progress in Trypanosoma brucei. PMID:25888089
Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. PMID:25768284
Comprehensive proteomics analysis of glycosomes from Leishmania donovani. PMID:25748437
New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource. PMID:25740547
Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis. PMID:25679388
Mitochondrial heat shock protein machinery hsp70/hsp40 is indispensable for proper mitochondrial DNA maintenance and replication. PMID:25670781
Phytomonas: trypanosomatids adapted to plant environments. PMID:25607944
Comparative in-silico genome analysis of Leishmania (Leishmania) donovani: A step towards its species specificity. PMID:25606461
Improving serodiagnosis of human and canine leishmaniasis with recombinant Leishmania braziliensis cathepsin l-like protein and a synthetic peptide containing its linear B-cell epitope. PMID:25569432
A toolkit enabling efficient, scalable and reproducible gene tagging in trypanosomatids. PMID:25567099
Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster. PMID:25536859
Identification of a candidate rad1 subunit for the kinetoplastid 9-1-1 (rad9-hus1-rad1) complex. PMID:25534152
Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes. PMID:25522361
Intrinsically disordered proteins (IDPs) in trypanosomatids. PMID:25496281
TLR9 activation is triggered by the excess of stimulatory versus inhibitory motifs present in Trypanosomatidae DNA. PMID:25392997
The Eukaryotic Pathogen Databases: a functional genomic resource integrating data from human and veterinary parasites. PMID:25388105
TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. PMID:25300491
Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability. PMID:25232945
The mRNAs associated to a zinc finger protein from Trypanosoma cruzi shift during stress conditions. PMID:25180711
International glossina genome initiative 2004-2014: a driver for post-genomic era research on the African continent. PMID:25144472
Evidence for loss of a partial flagellar glycolytic pathway during trypanosomatid evolution. PMID:25050549
An orthology-based analysis of pathogenic protozoa impacting global health: an improved comparative genomics approach with prokaryotes and model eukaryote orthologs. PMID:24960463
The epigenome of Trypanosoma brucei: a regulatory interface to an unconventional transcriptional machine. PMID:24942804
Proteomic selection of immunodiagnostic antigens for Trypanosoma congolense. PMID:24922510
Mapping B-cell epitopes for the peroxidoxin of Leishmania (Viannia) braziliensis and its potential for the clinical diagnosis of tegumentary and visceral leishmaniasis. PMID:24921246
Insect stage-specific receptor adenylate cyclases are localized to distinct subdomains of the Trypanosoma brucei Flagellar membrane. PMID:24879126
Trypanosoma brucei translation initiation factor homolog EIF4E6 forms a tripartite cytosolic complex with EIF4G5 and a capping enzyme homolog. PMID:24839125
Genetic profiling of the isoprenoid and sterol biosynthesis pathway genes of Trypanosoma cruzi. PMID:24828104
Epitope mapping of the HSP83.1 protein of Leishmania braziliensis discloses novel targets for immunodiagnosis of tegumentary and visceral clinical forms of leishmaniasis. PMID:24807053
High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics. PMID:24792668
A draft genome of the honey bee trypanosomatid parasite Crithidia mellificae. PMID:24743507
Investigating the Chaperone Properties of a Novel Heat Shock Protein, Hsp70.c, from Trypanosoma brucei. PMID:24707395
The endocytic activity of the flagellar pocket in Trypanosoma brucei is regulated by an adjacent phosphatidylinositol phosphate kinase. PMID:24639465
Tetrahymena thermophila: a divergent perspective on membrane traffic. PMID:24634411
Metabolic reprogramming during purine stress in the protozoan pathogen Leishmania donovani. PMID:24586154
The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants. PMID:24516393
The calmodulin intergenic spacer as molecular target for characterization of Leishmania species. PMID:24438764
More than meets the eye: understanding Trypanosoma brucei morphology in the tsetse. PMID:24312899
Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant. PMID:24312377
Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum. PMID:24278495
The limits on trypanosomatid morphological diversity. PMID:24260255
Identification of a secreted casein kinase 1 in Leishmania donovani: effect of protein over expression on parasite growth and virulence. PMID:24260187
Extracellular vesicles shed by Trypanosoma cruzi are linked to small RNA pathways, life cycle regulation, and susceptibility to infection of mammalian cells. PMID:24241124
Role of gap junctions and hemichannels in parasitic infections. PMID:24236292
Identification of strain-specific B-cell epitopes in Trypanosoma cruzi using genome-scale epitope prediction and high-throughput immunoscreening with peptide arrays. PMID:24205430
Plasmid vectors and molecular building blocks for the development of genetic manipulation tools for Trypanosoma cruzi. PMID:24205392
Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design. PMID:24147171
Trypanosoma brucei vacuolar transporter chaperone 4 (TbVtc4) is an acidocalcisome polyphosphate kinase required for in vivo infection. PMID:24114837
The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host. PMID:23998526
TcTASV-C, a protein family in Trypanosoma cruzi that is predominantly trypomastigote-stage specific and secreted to the medium. PMID:23923058
Trypanosome Letm1 protein is essential for mitochondrial potassium homeostasis. PMID:23893410
Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA. PMID:23877697
The genome sequence of Leishmania (Leishmania) amazonensis: functional annotation and extended analysis of gene models. PMID:23857904
Regulation of Trypanosoma brucei Total and Polysomal mRNA during Development within Its Mammalian Host. PMID:23840587
Identification and analysis of putative homologues of mechanosensitive channels in pathogenic protozoa. PMID:23785469
KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes. PMID:23766511
Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue. PMID:23750752
Comparative transcriptome analysis of small noncoding RNAs in different stages of Trypanosoma brucei. PMID:23704326
Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections. PMID:23583962
Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei. PMID:23485197
Adenylosuccinate synthetase and adenylosuccinate lyase deficiencies trigger growth and infectivity deficits in Leishmania donovani. PMID:23404497
Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels. PMID:23382545
Distinct genomic organization, mRNA expression and cellular localization of members of two amastin sub-families present in Trypanosoma cruzi. PMID:23327097
Diagnostic peptide discovery: prioritization of pathogen diagnostic markers using multiple features. PMID:23272069
A genomic scale map of genetic diversity in Trypanosoma cruzi. PMID:23270511
Novel bilobe components in Trypanosoma brucei identified using proximity-dependent biotinylation. PMID:23264645
Computational prediction of protein-protein interactions in Leishmania predicted proteomes. PMID:23251492
Purification, crystallization and X-ray diffraction analysis of Trypanosoma congolense insect-stage surface antigen (TcCISSA). PMID:23192033
EuPathDB: the eukaryotic pathogen database. PMID:23175615
'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana. PMID:23170981
Unusual domain architecture of aminoacyl tRNA synthetases and their paralogs from Leishmania major. PMID:23151081
Generation of Leishmania hybrids by whole genomic DNA transformation. PMID:23029579
Chromatin immunoprecipitation and microarray analysis reveal that TFIIB occupies the SL RNA gene promoter region in Trypanosoma brucei chromosomes. PMID:22999857
Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei. PMID:22908928
ALDH2 mediates 5-nitrofuran activity in multiple species. PMID:22840776
Parasites, proteomes and systems: has Descartes' clock run out of time? PMID:22828391
Purine salvage in Leishmania: complex or simple by design? PMID:22726696
Genome organization is a major component of gene expression control in response to stress and during the cell division cycle in trypanosomes. PMID:22724062
Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase. PMID:22676716
A modular and optimized single marker system for generating Trypanosoma brucei cell lines expressing T7 RNA polymerase and the tetracycline repressor. PMID:22645659
The Ontology for Parasite Lifecycle (OPL): towards a consistent vocabulary of lifecycle stages in parasitic organisms. PMID:22621763
Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages. PMID:22574199
On the evolution of hexose transporters in kinetoplastid Protozoans [corrected]. PMID:22567148
Multiple mitochondrial introgression events and heteroplasmy in trypanosoma cruzi revealed by maxicircle MLST and next generation sequencing. PMID:22506081
A 43-nucleotide U-rich element in 3'-untranslated region of large number of Trypanosoma cruzi transcripts is important for mRNA abundance in intracellular amastigotes. PMID:22500021
Trypanosomatid comparative genomics: Contributions to the study of parasite biology and different parasitic diseases. PMID:22481868
The orthologue of Sjögren's syndrome nuclear autoantigen 1 (SSNA1) in Trypanosoma brucei is an immunogenic self-assembling molecule. PMID:22363749
Assignment of putative functions to membrane "hypothetical proteins" from the Trypanosoma cruzi genome. PMID:22354180
Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing. PMID:22348164
A semantic problem solving environment for integrative parasite research: identification of intervention targets for Trypanosoma cruzi. PMID:22272365
Trypanosoma cruzi gene expression in response to gamma radiation. PMID:22247781
The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei. PMID:22140102
GeneDB--an annotation database for pathogens. PMID:22116062
Peroxiredoxins in parasites. PMID:22098136
The genetic toolbox for Leishmania parasites. PMID:22067831
Late endosomal Rab7 regulates lysosomal trafficking of endocytic but not biosynthetic cargo in Trypanosoma brucei. PMID:21923766
The short non-coding transcriptome of the protozoan parasite Trypanosoma cruzi. PMID:21912713
Amino acid determinants of substrate selectivity in the Trypanosoma brucei sphingolipid synthase family. PMID:21899277
Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts. PMID:21853145
Independent analysis of the flagellum surface and matrix proteomes provides insight into flagellum signaling in mammalian-infectious Trypanosoma brucei. PMID:21685506
Role of heme and heme-proteins in trypanosomatid essential metabolic pathways. PMID:21603276
Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei. PMID:21531904
The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization. PMID:21507942
Shotgun sequencing analysis of Trypanosoma cruzi I Sylvio X10/1 and comparison with T. cruzi VI CL Brener. PMID:21408126
Requirement for acetyl-CoA carboxylase in Trypanosoma brucei is dependent upon the growth environment. PMID:21306439
Biased cellular locations of tandem repeat antigens in African trypanosomes. PMID:21241659
Nutrient transport and pathogenesis in selected parasitic protozoa. PMID:21216940
Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major. PMID:20976268
AmoebaDB and MicrosporidiaDB: functional genomic resources for Amoebozoa and Microsporidia species. PMID:20974635
TcTASV: a novel protein family in trypanosoma cruzi identified from a subtractive trypomastigote cDNA library. PMID:20957201
The transcriptome of the human pathogen Trypanosoma brucei at single-nucleotide resolution. PMID:20838601
Functional genome annotation by combined analysis across microarray studies of Trypanosoma brucei. PMID:20824174
Identification of attractive drug targets in neglected-disease pathogens using an in silico approach. PMID:20808766
The pre-mRNA splicing machinery of trypanosomes: complex or simplified? PMID:20581293
Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major. PMID:20444260
The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis. PMID:20404998
Upregulated expression of B-cell antigen family tandem repeat proteins by Leishmania amastigotes. PMID:20160013
http://nar.oxfordjournals.org/content/38/suppl_1/D457

Tags:

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More detailed information about this field from each metasource.

genome
metasource: Fairsharing.org
version: FAIRsharing.org: TriTrypDB; TriTrypDB; DOI: https://doi.org/10.25504/FAIRsharing.fs1z27; Last edited: Feb. 24, 2021, 4:42 p.m.; Last accessed: Jan 03 2022 7:07 p.m.

pathogen
metasource: Fairsharing.org
version: FAIRsharing.org: TriTrypDB; TriTrypDB; DOI: https://doi.org/10.25504/FAIRsharing.fs1z27; Last edited: Feb. 24, 2021, 4:42 p.m.; Last accessed: Jan 03 2022 7:07 p.m.

genomics databases (non-vertebrate)
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

invertebrate genome databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

eedotrypanum
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

fair
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

biology
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

crithidia
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

euglenozoa
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

eukaryotic pathogens
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

genetics
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

genomics
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

kinetoplatid genomes
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

leishmania
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

metabolic pathways
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

pathogen researcher
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

trypanosoma
metasource: re3data.org
version: re3data.org: TriTrypDB; editing status 2021-10-08; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3J05N last accessed: 2022-11-04

model organisms
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:01.651645

metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:01.651645

metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:01.651645

animals
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:01.651645

genome pathogen genomics invertebrate genome eedotrypanum crithidia euglenozoa eukaryotic pathogens genetics genomics kinetoplatid genomes leishmania metabolic and signaling pathways pathogen researcher trypanosoma model organisms animals

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MicrosporidiaDB

TrichDB

ApiDB - Apicomplexan DataBase

Eukaryotic Pathogen, Vector and Host Informatics Resource

GeneDB

ToxoDB

Fungal and Oomycete genomics resource

CryptoDB

AmoebaDB

PlasmoDB

Target Pathogen

ProtozoaDB

GiardiaDB

Alliance of Genome Resources

EuPath Ontology

UCSC Genome Browser database

Ensembl

TcruziDB

NEMBASE

Viral Bioinformatics Resource