REFOLDdb
Names
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REFOLDdb
metasource: Fairsharing.org
version: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
metasource: re3data.org
version: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
REFOLD
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
including: REFOLD
metasource: re3data.org
version: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
Names
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REFOLDdb
metasource: Fairsharing.orgversion: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
metasource: re3data.org
version: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
REFOLD
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
including: REFOLD
metasource: re3data.orgversion: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
Other names: REFOLD, including: REFOLD
Names
More detailed information about this field from each metasource.
REFOLDdb
metasource: Fairsharing.orgversion: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
metasource: re3data.org
version: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
REFOLD
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
including: REFOLD
metasource: re3data.orgversion: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
REFOLDdb is a resource for the optimization of protein refolding, referring to published methods employed in the refolding of recombinant proteins. It stores a collection of published experimental approaches and records for refolding proteins. It contains data converted from the original REFOLD database that had been created and updated until 2009 by Monash University in Australia, as well as data retrieved from articles on refold technologies published since 2009.
Description
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REFOLDdb is a resource for the optimization of protein refolding, referring to published methods employed in the refolding of recombinant proteins. It stores a collection of published experimental approaches and records for refolding proteins. It contains data converted from the original REFOLD database that had been created and updated until 2009 by Monash University in Australia, as well as data retrieved from articles on refold technologies published since 2009.
metasource: Fairsharing.orgversion: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
The majority of human proteins expressed in bacteria are insoluble and thus require renaturation. Identifying the optimal refolding conditions and methodology is therefore rate limiting. In order to address this problem, we have catalogued the methods employed in the refolding of proteins in a web-accessible relational database, REFOLD. Entries are heavily annotated such that the database can be searched via multiple parameters. The database will have two roles: First, as a data repository and experimental resource, new data can be rapidly deposited, validated and made available to the refolding and wider scientific community. Much valuable refolding data goes unpublished (for example, in cases where a protein cannot be refolded for structural studies), thus we aim to exploit this untapped resource by encouraging deposition in REFOLD. The database will thus become a powerful experimental tool for the optimization of protein expression, refolding and purification, bypassing the relatively slow and inefficient examination of the literature. Second, REFOLD will become a valuable resource for theoreticians looking for relationships between refolding success and protein characteristics such as charge and hydrophobicity. Data mining may uncover general predictive rules that could facilitate the refolding of novel proteins.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
REFOLD has merged to REFOLDdb. REFOLDdb is a unique database for the life sciences research community, providing annotated information for designing new refolding protocols and customizing existing methodologies. We envisage that this resource will find wide utility across broad disciplines that rely on the production of pure, active, recombinant proteins. Furthermore, the database also provides a useful overview of the recent trends and statistics in refolding technology development.We based our resource on the existing REFOLD database, which has not been updated since 2009. We redesigned the data format to be more concise, allowing consistent representations among data entries compared with the original REFOLD database. The remodeled data architecture enhances the search efficiency and improves the sustainability of the database. After an exhaustive literature search we added experimental refolding protocols from reports published 2009 to early 2017. In addition to this new data, we fully converted and integrated existing REFOLD data into our new resource.
metasource: re3data.orgversion: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
Webpage:
https://pford.info/refolddb/Webpage
More detailed information about this field from each metasource.
https://pford.info/refolddb/
metasource: Fairsharing.orgversion: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
http://pford.info/refolddb/?lang=EN
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
http://p4d-info.nig.ac.jp/refolddatabase/
metasource: re3data.orgversion: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
Licence:
Name: Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)Licence name
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Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)
metasource: Fairsharing.orgversion: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
Copyrights
metasource: re3data.orgversion: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
Licence URL
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https://creativecommons.org/licenses/by-sa/4.0/
metasource: Fairsharing.orgversion: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
http://www.monash.edu.au/disclaimer-copyright.html
metasource: re3data.orgversion: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
Publications:
Publications
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The REFOLD database: a tool for the optimization of protein expression and refolding
PMID: 16381847
metasource: Fairsharing.org
version: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
Publications
More detailed information about this field from each metasource.
The REFOLD database: a tool for the optimization of protein expression and refolding
PMID: 16381847
metasource: Fairsharing.org
version: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
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The REFOLD database: a tool for the optimization of protein expression and refolding
PubMed citations: 10.
10 articles citing: The REFOLD database: a tool for the optimization of protein expression and refolding
Heterologous Expression, Purification, and Immunomodulatory Effects of Recombinant Lipoprotein GUDIV-103 Isolated from Ureaplasma diversum. PMID:35630474
A Code Within a Code: How Codons Fine-Tune Protein Folding in the Cell. PMID:34488574
Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization. PMID:30718507
REFOLDdb: a new and sustainable gateway to experimental protocols for protein refolding. PMID:28438161
Inclusion bodies: not that bad…. PMID:24592259
A successful strategy for the recovering of active P21, an insoluble recombinant protein of Trypanosoma cruzi. PMID:24590372
A multipurpose fusion tag derived from an unstructured and hyperacidic region of the amyloid precursor protein. PMID:23526492
Redesign of a plugged beta-barrel membrane protein. PMID:21189254
Construction of a series of vectors for high throughput cloning and expression screening of membrane proteins from Mycobacterium tuberculosis. PMID:18485215
pC6-2/caspase-6 system to purify glutathione-S-transferase-free recombinant fusion proteins expressed in Escherichia coli. PMID:17487164
Tags:
Tags
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molecular structure
metasource: Fairsharing.org
version: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
protein
metasource: Fairsharing.org
version: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
metasource: re3data.org
version: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
protein folding
metasource: Fairsharing.org
version: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
structure
metasource: Fairsharing.org
version: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
protein sequence databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
protein properties
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
cell biology
metasource: re3data.org
version: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
molecular biology
metasource: re3data.org
version: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
nutrition
metasource: re3data.org
version: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
Tags
More detailed information about this field from each metasource.
molecular structure
metasource: Fairsharing.orgversion: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
protein
metasource: Fairsharing.orgversion: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
metasource: re3data.org
version: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
protein folding
metasource: Fairsharing.orgversion: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
structure
metasource: Fairsharing.orgversion: FAIRsharing.org: REFOLDdb; REFOLDdb; DOI: https://doi.org/10.25504/FAIRsharing.2srshy; Last edited: June 25, 2021, 2:44 p.m.; Last accessed: Jan 03 2022 7:05 p.m.
protein sequence databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
protein properties
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
cell biology
metasource: re3data.orgversion: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
molecular biology
metasource: re3data.orgversion: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
nutrition
metasource: re3data.orgversion: re3data.org: REFOLDdb; editing status 2021-09-02; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3PC96 last accessed: 2022-11-04
molecular structure protein protein folding structure protein sequence protein properties cell biology molecular biology nutrition
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