ConoServer
Names
More detailed information about this field from each metasource.
ConoServer
metasource: Fairsharing.org
version: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Cone snail toxin database ConoServer
metasource: bio.tools
version: extracted_at: 2022-11-04T11:32:33.962827
conoserver
metasource: bio.tools
version: extracted_at: 2022-11-04T11:32:33.962827
Names
More detailed information about this field from each metasource.
ConoServer
metasource: Fairsharing.orgversion: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Cone snail toxin database ConoServer
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:32:33.962827
conoserver
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:32:33.962827
Other names: Cone snail toxin database ConoServer, conoserver
Names
More detailed information about this field from each metasource.
ConoServer
metasource: Fairsharing.orgversion: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Cone snail toxin database ConoServer
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:32:33.962827
conoserver
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:32:33.962827
ConoServer is a database specializing in sequences and structures of peptides expressed by marine cone snails. The database gives access to protein sequences, nucleic acid sequences and structural information on conopeptides. ConoServer's data are first collected from the peer reviewed literature and from publicly available databases, including UniProtKB/Swiss-Prot, NCBI nucleotide (nt), and the World Wide Protein Data Bank. The data are then curated manually, which include the addition of references, the analysis of sequence regions, the identification of cysteine frameworks and gene superfamilies, and the identification of mature peptides in the precusor sequences.
Description
More detailed information about this field from each metasource.
ConoServer is a database specializing in sequences and structures of peptides expressed by marine cone snails. The database gives access to protein sequences, nucleic acid sequences and structural information on conopeptides. ConoServer's data are first collected from the peer reviewed literature and from publicly available databases, including UniProtKB/Swiss-Prot, NCBI nucleotide (nt), and the World Wide Protein Data Bank. The data are then curated manually, which include the addition of references, the analysis of sequence regions, the identification of cysteine frameworks and gene superfamilies, and the identification of mature peptides in the precusor sequences.
metasource: Fairsharing.orgversion: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
Sequence and structures of peptides expressed by marine cone snails
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Database specializing in the sequence and structures of conopeptides, which are peptides expressed by carnivorous marine cone snails.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:32:33.962827
Webpage:
http://www.conoserver.orgWebpage
More detailed information about this field from each metasource.
http://www.conoserver.org
metasource: Fairsharing.orgversion: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
http://www.conoserver.org/
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:32:33.962827
Licence:
Name: ConoServer Permission required for commercial useLicence name
More detailed information about this field from each metasource.
ConoServer Permission required for commercial use
metasource: Fairsharing.orgversion: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
Licence URL
More detailed information about this field from each metasource.
http://www.conoserver.org/
metasource: Fairsharing.orgversion: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
Publications:
(6)
Publications
More detailed information about this field from each metasource.
Conus venoms: a rich source of novel ion channel-targeted peptides
PMID: 14715910
metasource: Fairsharing.org
version: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database
PMID: 22058133
metasource: bio.tools
version: extracted_at: 2022-11-04T11:32:33.962827
ConoServer, a database for conopeptide sequences and structures
PMID: 18065428
metasource: Fairsharing.org
version: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:32:33.962827
Conopeptide characterization and classifications: an analysis using ConoServer
PMID: 20211197
metasource: Fairsharing.org
version: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
Chemical modification of conotoxins to improve stability and activity
PMID: 17649970
metasource: Fairsharing.org
version: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
http://dx.doi.org/10.1093/nar/GKR886
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
More detailed information about this field from each metasource.
Conus venoms: a rich source of novel ion channel-targeted peptides
PMID: 14715910
metasource: Fairsharing.org
version: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database
PMID: 22058133
metasource: bio.tools
version: extracted_at: 2022-11-04T11:32:33.962827
ConoServer, a database for conopeptide sequences and structures
PMID: 18065428
metasource: Fairsharing.org
version: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:32:33.962827
Conopeptide characterization and classifications: an analysis using ConoServer
PMID: 20211197
metasource: Fairsharing.org
version: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
Chemical modification of conotoxins to improve stability and activity
PMID: 17649970
metasource: Fairsharing.org
version: FAIRsharing.org: ConoServer; ConoServer; DOI: https://doi.org/10.25504/FAIRsharing.y00hz4; Last edited: April 26, 2021, 8:18 a.m.; Last accessed: Jan 03 2022 7:09 p.m.
http://dx.doi.org/10.1093/nar/GKR886
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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Conus venoms: a rich source of novel ion channel-targeted peptides
PubMed citations: 275.
275 articles citing: Conus venoms: a rich source of novel ion channel-targeted peptides
A Novel Dimeric Conotoxin, FrXXA, from the Vermivorous Cone Snail Conus fergusoni, of the Eastern Pacific, Inhibits Nicotinic Acetylcholine Receptors. PMID:35893752
Pathophysiological Responses to Conotoxin Modulation of Voltage-Gated Ion Currents. PMID:35621933
Role of the disulfide bond on the structure and activity of μ-conotoxin PIIIA in the inhibition of NaV1.4. PMID:35517619
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors. PMID:35377397
A Novel α4/7-Conotoxin QuIA Selectively Inhibits α3β2 and α6/α3β4 Nicotinic Acetylcholine Receptor Subtypes with High Efficacy. PMID:35200675
Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers. PMID:35167877
Peptidylglycine α-amidating monooxygenase as a therapeutic target or biomarker for human diseases. PMID:35124797
Neglected Venomous Animals and Toxins: Underrated Biotechnological Tools in Drug Development. PMID:34941689
From Crystal Structures of RgIA4 in Complex with Ac-AChBP to Molecular Determinants of Its High Potency of α9α10 nAChR. PMID:34940708
Proteomic analysis of Red Sea Conus taeniatus venom reveals potential biological applications. PMID:34712278
Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins. PMID:34677461
Potential Therapeutic Applications of Synthetic Conotoxin s-cal14.2b, Derived from Californiconus californicus, for Treating Type 2 Diabetes. PMID:34440140
DisCoTune: versatile auxiliary plasmids for the production of disulphide-containing proteins and peptides in the E. coli T7 system. PMID:34405535
Potency- and Selectivity-Enhancing Mutations of Conotoxins for Nicotinic Acetylcholine Receptors Can Be Predicted Using Accurate Free-Energy Calculations. PMID:34202022
Localization and Bioreactivity of Cysteine-Rich Secretions in the Marine Gastropod Nucella lapillus. PMID:34063509
Mass spectrometric identification and denovo sequencing of novel conotoxins from vermivorous cone snail (Conus inscriptus), and preliminary screening of its venom for biological activities in vitro and in vivo. PMID:33732044
Proteomic and Transcriptomic Techniques to Decipher the Molecular Evolution of Venoms. PMID:33669432
The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus. PMID:33619264
Chemical Synthesis and NMR Solution Structure of Conotoxin GXIA from Conus geographus. PMID:33530397
Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor. PMID:33023152
Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes. PMID:32823677
Purification and Characterization of the Pink-Floyd Drillipeptide, a Bioactive Venom Peptide from Clavus davidgilmouri (Gastropoda: Conoidea: Drilliidae). PMID:32784699
Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research. PMID:32708023
The α9α10 nicotinic acetylcholine receptors antagonist α-conotoxin RgIA reverses colitis signs in murine dextran sodium sulfate model. PMID:32645334
An Integrated Proteomic and Transcriptomic Analysis Reveals the Venom Complexity of the Bullet Ant Paraponera clavata. PMID:32422990
Transcriptomic Profiling Reveals Extraordinary Diversity of Venom Peptides in Unexplored Predatory Gastropods of the Genus Clavus. PMID:32333764
αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish. PMID:32245200
Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors. PMID:32234761
Structural and Functional Characterization of Conotoxins from Conus achatinus Targeting NMDAR. PMID:32111068
Proapoptotic Index Evaluation of Two Synthetic Peptides Derived from the Coneshell Californiconus californicus in Lung Cancer Cell Line H1299. PMID:31861952
Proteo-Transcriptomic Characterization of the Venom from the Endoparasitoid Wasp Pimpla turionellae with Aspects on Its Biology and Evolution. PMID:31835557
Conotoxin Diversity in the Venom Gland Transcriptome of the Magician's Cone, Pionoconus magus. PMID:31569823
Identification and Functional Characterization of a Novel Insecticidal Decapeptide from the Myrmicine Ant Manica rubida. PMID:31557881
Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA. PMID:31470595
α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice. PMID:31443523
α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors. PMID:31255696
Structural and Functional Analyses of Cone Snail Toxins. PMID:31234371
Kalium 2.0, a comprehensive database of polypeptide ligands of potassium channels. PMID:31133708
Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors. PMID:31118896
High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing. PMID:30917600
In Silico Analysis of the Subtype Selective Blockage of KCNA Ion Channels through the µ-Conotoxins PIIIA, SIIIA, and GIIIA. PMID:30893914
Snails In Silico: A Review of Computational Studies on the Conopeptides. PMID:30832207
d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability. PMID:30823399
Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors. PMID:30781866
Proteomic Analysis of the Venom from the Ruby Ant Myrmica rubra and the Isolation of a Novel Insecticidal Decapeptide. PMID:30717163
Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, Conus tulipa. PMID:30669642
Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects. PMID:30669328
Discovery Methodology of Novel Conotoxins from Conus Species. PMID:30380764
Conopeptides promote itch through human itch receptor hMgprX1. PMID:30243794
Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. PMID:30194442
Exploring the role of stromal osmoregulation in cancer and disease using executable modelling. PMID:30069015
Conotoxin Diversity in Chelyconus ermineus (Born, 1778) and the Convergent Origin of Piscivory in the Atlantic and Indo-Pacific Cones. PMID:30060147
Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor. PMID:29925760
Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-Gated Sodium Channels from Binding Energy Calculations. PMID:29735899
Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods. PMID:29621159
Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes. PMID:29360782
Structural plasticity of mini-M conotoxins - expression of all mini-M subtypes by Conus regius. PMID:29283511
Overlooked Short Toxin-Like Proteins: A Shortcut to Drug Design. PMID:29109389
Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (CaV) Channels. PMID:29027927
µ-Conotoxins Modulating Sodium Currents in Pain Perception and Transmission: A Therapeutic Potential. PMID:28937587
Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. PMID:28851841
A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus). PMID:28718820
Recent Advances in Conotoxin Classification by Using Machine Learning Methods. PMID:28672838
Identification of a Novel O-Conotoxin Reveals an Unusual and Potent Inhibitor of the Human α9α10 Nicotinic Acetylcholine Receptor. PMID:28598389
A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from αD-Conotoxin GeXXA. PMID:28587231
The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea. PMID:28531118
Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain. PMID:28396446
Direct palladium-mediated on-resin disulfide formation from Allocam protected peptides. PMID:28327729
Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system. PMID:28259138
Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin. PMID:28245769
Marine-Derived Pharmaceuticals - Challenges and Opportunities. PMID:27795450
Fluorescent protein-scorpion toxin chimera is a convenient molecular tool for studies of potassium channels. PMID:27650866
Identifying the Types of Ion Channel-Targeted Conotoxins by Incorporating New Properties of Residues into Pseudo Amino Acid Composition. PMID:27631006
Integration of Next Generation Sequencing and EPR Analysis to Uncover Molecular Mechanism Underlying Shell Color Variation in Scallops. PMID:27563719
Small Packages, Big Returns: Uncovering the Venom Diversity of Small Invertebrate Conoidean Snails. PMID:27371389
Screening for Anti-Cancer Compounds in Marine Organisms in Oman. PMID:27226907
Transcriptomic Analysis of Differentially Expressed Genes During Larval Development of Rapana venosa by Digital Gene Expression Profiling. PMID:27194808
From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins. PMID:27104567
High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing. PMID:27087938
In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii. PMID:27070627
Characterization and Recombinant Expression of Terebrid Venom Peptide from Terebra guttata. PMID:26950153
Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom. PMID:26861394
Glycine-rich conotoxins from the Virgiconus clade. PMID:26851775
The Biochemical Toxin Arsenal from Ant Venoms. PMID:26805882
The hitchhiker's guide to the voltage-gated sodium channel galaxy. PMID:26712848
Computational Studies of Venom Peptides Targeting Potassium Channels. PMID:26633507
Prey-Capture Strategies of Fish-Hunting Cone Snails: Behavior, Neurobiology and Evolution. PMID:26397110
Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. PMID:26395518
Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel. PMID:26389953
Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. PMID:26290113
Mechanism of Ion Permeation in Mammalian Voltage-Gated Sodium Channels. PMID:26274802
Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers. PMID:26234920
Identification and Characterization of a Novel Family of Cysteine-Rich Peptides (MgCRP-I) from Mytilus galloprovincialis. PMID:26201648
Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks. PMID:26150494
αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors. PMID:26074268
Molecular Diversity and Gene Evolution of the Venom Arsenal of Terebridae Predatory Marine Snails. PMID:26025559
Bioactive components in fish venoms. PMID:25941767
Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus. PMID:25848010
Conantokin-G attenuates detrimental effects of NMDAR hyperactivity in an ischemic rat model of stroke. PMID:25822337
Human β-defensin 4 with non-native disulfide bridges exhibit antimicrobial activity. PMID:25785690
Analgesic effect of Persian Gulf Conus textile venom. PMID:25729549
Specialized insulin is used for chemical warfare by fish-hunting cone snails. PMID:25605914
Systematic study of binding of μ-conotoxins to the sodium channel NaV1.4. PMID:25529306
Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom. PMID:25464369
Native chemical ligation: a boon to peptide chemistry. PMID:25221869
Molecular dynamics study of binding of µ-conotoxin GIIIA to the voltage-gated sodium channel Na(v)1.4. PMID:25133704
Omega-conotoxin MVIIC attenuates neuronal apoptosis in vitro and improves significant recovery after spinal cord injury in vivo in rats. PMID:25120731
Are ticks venomous animals? PMID:25006341
Characterization of a novel Conus bandanus conopeptide belonging to the M-superfamily containing bromotryptophan. PMID:24905483
Conotoxins targeting nicotinic acetylcholine receptors: an overview. PMID:24857959
Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail. PMID:24833338
Animal toxins influence voltage-gated sodium channel function. PMID:24737238
Discovery, synthesis, and structure-activity relationships of conotoxins. PMID:24720541
Sample limited characterization of a novel disulfide-rich venom peptide toxin from terebrid marine snail Terebra variegata. PMID:24713808
Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels. PMID:24628243
The Concise Guide to PHARMACOLOGY 2013/14: ion channels. PMID:24528239
A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ. PMID:24497506
Influence of disulfide connectivity on structure and bioactivity of α-conotoxin TxIA. PMID:24434670
Semienzymatic cyclization of disulfide-rich peptides using Sortase A. PMID:24425873
A fully genetically encoded protein architecture for optical control of peptide ligand concentration. PMID:24407101
Conopeptide Vt3.1 preferentially inhibits BK potassium channels containing β4 subunits via electrostatic interactions. PMID:24398688
A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors. PMID:24398291
Conus: first comprehensive conservation red list assessment of a marine gastropod mollusc genus. PMID:24376693
Molecular evolution and diversity of Conus peptide toxins, as revealed by gene structure and intron sequence analyses. PMID:24349297
Preliminary results of the in vivo and in vitro characterization of a tentacle venom fraction from the jellyfish Aurelia aurita. PMID:24322597
Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signaling. PMID:24260577
On the importance of oxidative folding in the evolution of conotoxins: cysteine codon preservation through gene duplication and adaptation. PMID:24244311
Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors. PMID:24200193
Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. PMID:24131469
Various conotoxin diversifications revealed by a venomic study of Conus flavidus. PMID:24126141
Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. PMID:24100032
MabCent: Arctic marine bioprospecting in Norway. PMID:24078803
INTEGRATED APPROACHES TO THE CONFIGURATIONAL ASSIGNMENT OF MARINE NATURAL PRODUCTS. PMID:23814320
Strategies for the development of conotoxins as new therapeutic leads. PMID:23812174
Conopeptides from Cape Verde Conus crotchii. PMID:23783403
Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors. PMID:23698359
Computational methods of studying the binding of toxins from venomous animals to biological ion channels: theory and applications. PMID:23589832
Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency. PMID:23557677
α -RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom. PMID:23533449
Computational studies of marine toxins targeting ion channels. PMID:23528952
A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico. PMID:23474143
Glycosylation of conotoxins. PMID:23455513
Venom peptides as a rich source of cav2.2 channel blockers. PMID:23381143
A bacterial source for mollusk pyrone polyketides. PMID:23352141
Pharmacological fractionation of tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons by μ-conotoxins. PMID:23351163
Comparative analysis of proteases in the injected and dissected venom of cone snail species. PMID:23339854
pKa determination of histidine residues in α-conotoxin MII peptides by 1H NMR and constant pH molecular dynamics simulation. PMID:23336579
Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? PMID:23202314
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. PMID:23165928
Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins. PMID:23146020
Black mamba venom peptides target acid-sensing ion channels to abolish pain. PMID:23034652
Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes. PMID:22954218
Topography of native SK channels revealed by force nanoscopy in living neurons. PMID:22895725
Analysis of a cone snail's killer cocktail--the milked venom of Conus geographus. PMID:22884604
Dissecting a role of evolutionary-conserved but noncritical disulfide bridges in cysteine-rich peptides using ω-conotoxin GVIA and its selenocysteine analogs. PMID:22782563
Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons. PMID:22774996
Design of bioactive peptides from naturally occurring μ-conotoxin structures. PMID:22773842
Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct. PMID:22742208
Targeting voltage-gated calcium channels: developments in peptide and small-molecule inhibitors for the treatment of neuropathic pain. PMID:22725651
P/Q-type calcium channel modulators. PMID:22670568
Selective purification of recombinant neuroactive peptides using the flagellar type III secretion system. PMID:22647788
Chemical punch packed in venoms makes centipedes excellent predators. PMID:22595790
Receptor-targeting mechanisms of pain-causing toxins: How ow? PMID:22538196
Cone snail milked venom dynamics--a quantitative study of Conus purpurascens. PMID:22497788
Developing a comparative docking protocol for the prediction of peptide selectivity profiles: investigation of potassium channel toxins. PMID:22474570
Elucidating nature's solutions to heart, lung, and blood diseases and sleep disorders. PMID:22461362
Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB. PMID:22452751
Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion. PMID:22438204
A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily. PMID:22399292
Solution structure of kurtoxin: a gating modifier selective for Cav3 voltage-gated Ca(2+) channels. PMID:22329781
Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome. PMID:22325721
Binding modes of μ-conotoxin to the bacterial sodium channel (NaVAb). PMID:22325270
A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. PMID:22229737
Palmitoylation influences the function and pharmacology of sodium channels. PMID:22123950
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. PMID:22094702
Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels. PMID:22091786
Neurotoxins and their binding areas on voltage-gated sodium channels. PMID:22084632
Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads. PMID:22069647
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. PMID:22058133
Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA. PMID:21962108
An unusual family of glycosylated peptides isolated from Dendroaspis angusticeps venom and characterized by combination of collision induced and electron transfer dissociation. PMID:21952754
Characterization of a venom peptide from a crassispirid gastropod. PMID:21939682
Genetic divergence and geographic variation in the deep-water Conus orbignyi complex (Mollusca: Conoidea). PMID:21712968
μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. PMID:21652775
Conotoxin protein classification using free scores of words and support vector machines. PMID:21619696
Navβ subunits modulate the inhibition of Nav1.8 by the analgesic gating modifier μO-conotoxin MrVIB. PMID:21586605
A novel conotoxin, qc16a, with a unique cysteine framework and folding. PMID:21524672
Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin. PMID:21520911
Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function? PMID:21504902
Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin. PMID:21454658
Natural products and ion channel pharmacology. PMID:21426200
Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PMID:21390272
NMR and protein structure in drug design: application to cyclotides and conotoxins. PMID:21290122
Characterization of the Conus bullatus genome and its venom-duct transcriptome. PMID:21266071
Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels. PMID:21252227
Diversity of conotoxin types from Conus californicus reflects a diversity of prey types and a novel evolutionary history. PMID:21172372
Analgesic effect of highly reversible ω-conotoxin FVIA on N type Ca2+ channels. PMID:21172037
A diverse family of novel peptide toxins from an unusual cone snail, Conus californicus. PMID:21147978
Against expectation: a short sequence with high signal elucidates cone snail phylogeny. PMID:21147238
Intraspecies variability and conopeptide profiling of the injected venom of Conus ermineus. PMID:21126547
Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria. PMID:21028889
Functional hypervariability and gene diversity of cardioactive neuropeptides. PMID:20923766
The Terebridae and teretoxins: Combining phylogeny and anatomy for concerted discovery of bioactive compounds. PMID:20849634
Defining a Clade by Morphological, Molecular and Toxinological Criteria: Distinctive Forms related to Conus praecellens A. Adams, 1854. PMID:20835370
Chemical synthesis and characterization of two α4/7-conotoxins. PMID:20801929
α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. PMID:20739611
A novel approach for in vivo screening of toxins using the Drosophila Giant Fiber circuit. PMID:20723555
The tetrodotoxin receptor of voltage-gated sodium channels--perspectives from interactions with micro-conotoxins. PMID:20714429
A new subfamily of conotoxins belonging to the A-superfamily. PMID:20691232
Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2-adrenoceptors. PMID:20659106
Divergent M- and O-superfamily peptides from venom of fish-hunting Conus parius. PMID:20570703
9.3 KDa components of the injected venom of Conus purpurascens define a new five-disulfide conotoxin framework. PMID:20564010
A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. PMID:20510930
μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels. PMID:20459109
Mu-conotoxins as leads in the development of new analgesics. PMID:20428082
Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxin. PMID:20410356
Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. PMID:20363338
Proteomic analysis provides insights on venom processing in Conus textile. PMID:20334424
An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors. PMID:20308253
Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins. PMID:20220134
Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA. PMID:20175537
Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins. PMID:20147296
Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor. PMID:20145249
Silencing neurotransmission with membrane-tethered toxins. PMID:20139968
Targeting voltage sensors in sodium channels with spider toxins. PMID:20097434
Accessing novel conoidean venoms: Biodiverse lumun-lumun marine communities, an untapped biological and toxinological resource. PMID:20005243
Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators. PMID:19915728
Correlating molecular phylogeny with venom apparatus occurrence in Panamic auger snails (Terebridae). PMID:19890382
Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain. PMID:19707262
Searching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function. PMID:19603113
A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors. PMID:19481459
Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors. PMID:19448650
Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor. PMID:19447885
The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. PMID:19427876
Rapid sensitive analysis of cysteine rich peptide venom components. PMID:19380747
Mechanism and energetics of charybdotoxin unbinding from a potassium channel from molecular dynamics simulations. PMID:19348743
Neuroprotective and cardioprotective conopeptides: an emerging class of drug leads. PMID:19333868
Sea anemone toxins affecting voltage-gated sodium channels--molecular and evolutionary features. PMID:19268682
Cupryphans, metal-binding, redox-active, redesigned conopeptides. PMID:19241383
Ligands for ionotropic glutamate receptors. PMID:19184587
Drug development from marine natural products. PMID:19096380
Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. PMID:18950653
Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation. PMID:18945902
Alpha-conopeptides specifically expressed in the salivary gland of Conus pulicarius. PMID:18625510
alpha4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors. PMID:18588930
Conantokin-P, an unusual conantokin with a long disulfide loop. PMID:18586049
Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins. PMID:18586046
Structural answers and persistent questions about how nicotinic receptors work. PMID:18508600
Tyrosine-rich conopeptides affect voltage-gated K+ channels. PMID:18505731
Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. PMID:18486102
Toxins from cone snails: properties, applications and biotechnological production. PMID:18340446
Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues. PMID:18295795
Fragmentation of peptide disulfides under conditions of negative ion mass spectrometry: studies of oxidized glutathione and contryphan. PMID:18258450
Characterization of a novel psi-conotoxin from Conus parius Reeve. PMID:18054976
The mitochondrial genome of Conus textile, coxI-coxII intergenic sequences and Conoidean evolution. PMID:17936021
Structure and sodium channel activity of an excitatory I1-superfamily conotoxin. PMID:17696362
A vasopressin/oxytocin-related conopeptide with gamma-carboxyglutamate at position 8. PMID:17331075
Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins. PMID:17315952
An amino acid outside the pore region influences apamin sensitivity in small conductance Ca2+-activated K+ channels. PMID:17142458
De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry. PMID:17134143
Discovery and characterization of the short kappaA-conotoxins: a novel subfamily of excitatory conotoxins. PMID:17118419
Two toxins from Conus striatus that individually induce tetanic paralysis. PMID:17115716
Synthesis of fluorescent analogs of alpha-conotoxin MII. PMID:17105243
Tarantula toxins interacting with voltage sensors in potassium channels. PMID:17097703
Determinants of alpha-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor beta subunit. PMID:16964981
Structure of conkunitzin-S1, a neurotoxin and Kunitz-fold disulfide variant from cone snail. PMID:16929098
Potential for discovery of neuroprotective factors in serum and tissue from hibernating species. PMID:16918494
Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity. PMID:16669624
Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP. PMID:16505382
Genes expressed in a turrid venom duct: divergence and similarity to conotoxins. PMID:16477526
Expression of Rem2, an RGK family small GTPase, reduces N-type calcium current without affecting channel surface density. PMID:16237180
Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif. PMID:16207177
Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII. PMID:16162671
The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity. PMID:15955877
SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons. PMID:15880145 -
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database
PubMed citations: 136.
136 articles citing: ConoServer: updated content, knowledge, and discovery tools in the conopeptide database
Improving the Annotation of the Venom Gland Transcriptome of Pamphobeteus verdolaga, Prospecting Novel Bioactive Peptides. PMID:35737069
Total synthesis of μ-conotoxin lt5d. PMID:35558937
Malaria Parasite Plasmodium falciparum Proteins on the Surface of Infected Erythrocytes as Targets for Novel Drug Discovery. PMID:35501996
Venomics Reveals a Non-Compartmentalised Venom Gland in the Early Diverged Vermivorous Conus distans. PMID:35324723
Comparative Venomics of C. flavidus and C. frigidus and Closely Related Vermivorous Cone Snails. PMID:35323508
Comparative Venomics of the Cryptic Cone Snail Species Virroconus ebraeus and Virroconus judaeus. PMID:35200678
Biomedical Potential of the Neglected Molluscivorous and Vermivorous Conus Species. PMID:35200635
Structural and Functional Diversity of Animal Toxins Interacting With GPCRs. PMID:35198603
Neglected Venomous Animals and Toxins: Underrated Biotechnological Tools in Drug Development. PMID:34941689
Proteomic analysis of Red Sea Conus taeniatus venom reveals potential biological applications. PMID:34712278
Identification of Novel Conotoxin Precursors from the Cone Snail Conus spurius by High-Throughput RNA Sequencing. PMID:34677446
Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. PMID:34671739
A Combined Transcriptomics and Proteomics Approach Reveals the Differences in the Predatory and Defensive Venoms of the Molluscivorous Cone Snail Cylinder ammiralis (Caenogastropoda: Conidae). PMID:34564647
Remote homology clustering identifies lowly conserved families of effector proteins in plant-pathogenic fungi. PMID:34468307
A phylogeny-aware approach reveals unexpected venom components in divergent lineages of cone snails. PMID:34229491
Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus. PMID:34168165
Hormone-like conopeptides - new tools for pharmaceutical design. PMID:34095838
Proteogenomic Assessment of Intraspecific Venom Variability: Molecular Adaptations in the Venom Arsenal of Conus purpurascens. PMID:34029722
In silico Approaches for the Design and Optimization of Interfering Peptides Against Protein-Protein Interactions. PMID:33996914
Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus bayani as Determined from Transcriptomic and Proteomic Analyses. PMID:33916793
Combined Proteotranscriptomic-Based Strategy to Discover Novel Antimicrobial Peptides from Cone Snails. PMID:33805497
Synthesis, Structural and Pharmacological Characterizations of CIC, a Novel α-Conotoxin with an Extended N-Terminal Tail. PMID:33801301
Mass spectrometric identification and denovo sequencing of novel conotoxins from vermivorous cone snail (Conus inscriptus), and preliminary screening of its venom for biological activities in vitro and in vivo. PMID:33732044
Synthetic Biology and Computer-Based Frameworks for Antimicrobial Peptide Discovery. PMID:33538585
Identification of Conomarphin Variants in the Conus eburneus Venom and the Effect of Sequence and PTM Variations on Conomarphin Conformations. PMID:33019526
Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus. PMID:32937857
Purification and Characterization of the Pink-Floyd Drillipeptide, a Bioactive Venom Peptide from Clavus davidgilmouri (Gastropoda: Conoidea: Drilliidae). PMID:32784699
Conus coronatus and Conus frigidus Venom: A New Source of Conopeptides with Analgesic Activity. PMID:32695281
Neuropeptide signalling systems - An underexplored target for venom drug discovery. PMID:32619425
Recent advances in the biosynthesis of RiPPs from multicore-containing precursor peptides. PMID:32617877
Characterisation of a Novel A-Superfamily Conotoxin. PMID:32443665
Isolation and structural identification of a new T1-conotoxin with unique disulfide connectivities derived from Conus bandanus. PMID:32425993
Graph-Directed Approach for Downselecting Toxins for Experimental Structure Determination. PMID:32422972
Cysteines and Disulfide Bonds as Structure-Forming Units: Insights From Different Domains of Life and the Potential for Characterization by NMR. PMID:32391319
Transcriptomic Profiling Reveals Extraordinary Diversity of Venom Peptides in Unexplored Predatory Gastropods of the Genus Clavus. PMID:32333764
Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors. PMID:32234761
Insertions and Deletions Play an Important Role in the Diversity of Conotoxins. PMID:32170561
Proapoptotic Index Evaluation of Two Synthetic Peptides Derived from the Coneshell Californiconus californicus in Lung Cancer Cell Line H1299. PMID:31861952
Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors. PMID:31795126
Selecting Potential Neuronal Drug Leads from Conotoxins of Various Venomous Marine Cone Snails in Bali, Indonesia. PMID:31763573
ADAPTABLE: a comprehensive web platform of antimicrobial peptides tailored to the user's research. PMID:31740563
Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus. PMID:31661832
Conotoxin Diversity in the Venom Gland Transcriptome of the Magician's Cone, Pionoconus magus. PMID:31569823
Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi. PMID:31527432
Transcriptomic Analysis of Marine Gastropod Hemifusus tuba Provides Novel Insights into Conotoxin Genes. PMID:31405144
α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors. PMID:31255696
Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR. PMID:31214027
Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations. PMID:31126085
Informatics and Computational Methods in Natural Product Drug Discovery: A Review and Perspectives. PMID:31114606
High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing. PMID:30917600
Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis. PMID:30893765
Snails In Silico: A Review of Computational Studies on the Conopeptides. PMID:30832207
Lack of Signal for the Impact of Conotoxin Gene Diversity on Speciation Rates in Cone Snails. PMID:30816949
Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor. PMID:30747102
High Throughput Identification of Novel Conotoxins from the Vermivorous Oak Cone Snail (Conus quercinus) by Transcriptome Sequencing. PMID:30563163
Insights into the Folding of Disulfide-Rich μ-Conotoxins. PMID:30411002
Discovery Methodology of Novel Conotoxins from Conus Species. PMID:30380764
Nuclear Magnetic Resonance seq (NMRseq): A New Approach to Peptide Sequence Tags. PMID:30373307
Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity. PMID:30323294
Prediction of disulfide dihedral angles using chemical shifts. PMID:30310586
Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors. PMID:30249616
Piercing Fishes: Porin Expansion and Adaptation to Hematophagy in the Vampire Snail Cumia reticulata. PMID:30099551
Venomix: a simple bioinformatic pipeline for identifying and characterizing toxin gene candidates from transcriptomic data. PMID:30083468
Conotoxin Diversity in Chelyconus ermineus (Born, 1778) and the Convergent Origin of Piscivory in the Atlantic and Indo-Pacific Cones. PMID:30060147
Studying Smaller and Neglected Organisms in Modern Evolutionary Venomics Implementing RNASeq (Transcriptomics)-A Critical Guide. PMID:30012955
Classes, Databases, and Prediction Methods of Pharmaceutically and Commercially Important Cystine-Stabilized Peptides. PMID:29921767
Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails. PMID:29899286
Cloning, Synthesis and Functional Characterization of a Novel α-Conotoxin Lt1.3. PMID:29614714
Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. PMID:29567943
Venomics-Accelerated Cone Snail Venom Peptide Discovery. PMID:29522462
Targeted Sequencing of Venom Genes from Cone Snail Genomes Improves Understanding of Conotoxin Molecular Evolution. PMID:29514313
Accelerated proteomic visualization of individual predatory venoms of Conus purpurascens reveals separately evolved predation-evoked venom cabals. PMID:29321522
Aqueous ionic liquids influence the disulfide bond isoform equilibrium in conotoxin AuIB: a consequence of the Hofmeister effect? PMID:29294259
Are Fireworms Venomous? Evidence for the Convergent Evolution of Toxin Homologs in Three Species of Fireworms (Annelida, Amphinomidae). PMID:29293976
Computational Studies of Snake Venom Toxins. PMID:29271884
Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery. PMID:29215605
KNOTTIN: the database of inhibitor cystine knot scaffold after 10 years, toward a systematic structure modeling. PMID:29136213
Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (CaV) Channels. PMID:29027927
Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus. PMID:28922871
Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. PMID:28851841
RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia. PMID:28785206
Sodium channels and pain: from toxins to therapies. PMID:28749537
β-Ginkgotides: Hyperdisulfide-constrained peptides from Ginkgo biloba. PMID:28733600
Multiomics analysis of the giant triton snail salivary gland, a crown-of-thorns starfish predator. PMID:28729681
A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus). PMID:28718820
Recent Advances in Conotoxin Classification by Using Machine Learning Methods. PMID:28672838
α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors. PMID:28603989
Identification of a Novel O-Conotoxin Reveals an Unusual and Potent Inhibitor of the Human α9α10 Nicotinic Acetylcholine Receptor. PMID:28598389
Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. PMID:28542706
Antagonistic action on NMDA/GluN2B mediated currents of two peptides that were conantokin-G structure-based designed. PMID:28511693
αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype. PMID:28416445
From Marine Venoms to Drugs: Efficiently Supported by a Combination of Transcriptomics and Proteomics. PMID:28358320
Protein Bioinformatics Databases and Resources. PMID:28150231
Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. PMID:27801785
Dietary breadth is positively correlated with venom complexity in cone snails. PMID:27229931
From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins. PMID:27104567
Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. PMID:27093300
Prediction of Toxin Genes from Chinese Yellow Catfish Based on Transcriptomic and Proteomic Sequencing. PMID:27089325
High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing. PMID:27087938
Characterization and Recombinant Expression of Terebrid Venom Peptide from Terebra guttata. PMID:26950153
Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom. PMID:26861394
Glycine-rich conotoxins from the Virgiconus clade. PMID:26851775
Age-related association of venom gene expression and diet of predatory gastropods. PMID:26818019
SATPdb: a database of structurally annotated therapeutic peptides. PMID:26527728
Structural features of conopeptide genes inferred from partial sequences of the Conus tribblei genome. PMID:26423067
Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks. PMID:26150494
PredSTP: a highly accurate SVM based model to predict sequential cystine stabilized peptides. PMID:26142484
Bioinformatics-Aided Venomics. PMID:26110505
αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors. PMID:26074268
Comparison of the Venom Peptides and Their Expression in Closely Related Conus Species: Insights into Adaptive Post-speciation Evolution of Conus Exogenomes. PMID:26047846
Molecular Diversity and Gene Evolution of the Venom Arsenal of Terebridae Predatory Marine Snails. PMID:26025559
Key challenges for the creation and maintenance of specialist protein resources. PMID:25820941
High conopeptide diversity in Conus tribblei revealed through analysis of venom duct transcriptome using two high-throughput sequencing platforms. PMID:25117477
Characterization of a novel Conus bandanus conopeptide belonging to the M-superfamily containing bromotryptophan. PMID:24905483
Discovery, synthesis, and structure-activity relationships of conotoxins. PMID:24720541
Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. PMID:24662800
Cysteine pseudoprolines for thiol protection and peptide macrocyclization enhancement in Fmoc-based solid-phase peptide synthesis. PMID:24617568
Structure-function elucidation of a new α-conotoxin, Lo1a, from Conus longurionis. PMID:24567324
Influence of disulfide connectivity on structure and bioactivity of α-conotoxin TxIA. PMID:24434670
A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors. PMID:24398291
Molecular evolution and diversity of Conus peptide toxins, as revealed by gene structure and intron sequence analyses. PMID:24349297
Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. PMID:24131469
Various conotoxin diversifications revealed by a venomic study of Conus flavidus. PMID:24126141
Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. PMID:24043424
SVM-based prediction of propeptide cleavage sites in spider toxins identifies toxin innovation in an Australian tarantula. PMID:23894279
Strategies for the development of conotoxins as new therapeutic leads. PMID:23812174
Conopeptides from Cape Verde Conus crotchii. PMID:23783403
α -RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom. PMID:23533449
The insecticidal potential of venom peptides. PMID:23525661
A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico. PMID:23474143
Glycosylation of conotoxins. PMID:23455513
A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily. PMID:23382933
Scorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering. PMID:23202307
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. PMID:23152539
ConoDictor: a tool for prediction of conopeptide superfamilies. PMID:22661581
The UniProtKB/Swiss-Prot Tox-Prot program: A central hub of integrated venom protein data. PMID:22465017 -
ConoServer, a database for conopeptide sequences and structures
PubMed citations: 88.
88 articles citing: ConoServer, a database for conopeptide sequences and structures
Isolation and characterization of five novel disulfide-poor conopeptides from Conus marmoreus venom. PMID:35677566
Total synthesis of μ-conotoxin lt5d. PMID:35558937
Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers. PMID:35167877
Neglected Venomous Animals and Toxins: Underrated Biotechnological Tools in Drug Development. PMID:34941689
Proteomic analysis of Red Sea Conus taeniatus venom reveals potential biological applications. PMID:34712278
Interactions of Globular and Ribbon [γ4E]GID with α4β2 Neuronal Nicotinic Acetylcholine Receptor. PMID:34564144
A phylogeny-aware approach reveals unexpected venom components in divergent lineages of cone snails. PMID:34229491
Peptide Toxins Targeting KV Channels. PMID:34117930
Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides. PMID:34073203
Proteogenomic Assessment of Intraspecific Venom Variability: Molecular Adaptations in the Venom Arsenal of Conus purpurascens. PMID:34029722
Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus bayani as Determined from Transcriptomic and Proteomic Analyses. PMID:33916793
Synthesis, Structural and Pharmacological Characterizations of CIC, a Novel α-Conotoxin with an Extended N-Terminal Tail. PMID:33801301
Chemical Synthesis and NMR Solution Structure of Conotoxin GXIA from Conus geographus. PMID:33530397
Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus. PMID:32937857
ConoMode, a database for conopeptide binding modes. PMID:32754758
Recent advances in the biosynthesis of RiPPs from multicore-containing precursor peptides. PMID:32617877
Characterisation of a Novel A-Superfamily Conotoxin. PMID:32443665
Isolation and structural identification of a new T1-conotoxin with unique disulfide connectivities derived from Conus bandanus. PMID:32425993
Marine Toxins Targeting Kv1 Channels: Pharmacological Tools and Therapeutic Scaffolds. PMID:32245015
Selecting Potential Neuronal Drug Leads from Conotoxins of Various Venomous Marine Cone Snails in Bali, Indonesia. PMID:31763573
ADAPTABLE: a comprehensive web platform of antimicrobial peptides tailored to the user's research. PMID:31740563
Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus. PMID:31661832
Marine Toxins and Nociception: Potential Therapeutic Use in the Treatment of Visceral Pain Associated with Gastrointestinal Disorders. PMID:31370176
α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors. PMID:31255696
Structural and Functional Analyses of Cone Snail Toxins. PMID:31234371
Effects of Predator-Prey Interactions on Predator Traits: Differentiation of Diets and Venoms of a Marine Snail. PMID:31130611
Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations. PMID:31126085
High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing. PMID:30917600
Snails In Silico: A Review of Computational Studies on the Conopeptides. PMID:30832207
High Throughput Identification of Novel Conotoxins from the Vermivorous Oak Cone Snail (Conus quercinus) by Transcriptome Sequencing. PMID:30563163
Discovery of Novel Conotoxin Candidates Using Machine Learning. PMID:30513724
Insights into the Folding of Disulfide-Rich μ-Conotoxins. PMID:30411002
Discovery Methodology of Novel Conotoxins from Conus Species. PMID:30380764
Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity. PMID:30323294
Venomics: A Mini-Review. PMID:30041430
StraPep: a structure database of bioactive peptides. PMID:29688386
Venomics-Accelerated Cone Snail Venom Peptide Discovery. PMID:29522462
Aqueous ionic liquids influence the disulfide bond isoform equilibrium in conotoxin AuIB: a consequence of the Hofmeister effect? PMID:29294259
Are Fireworms Venomous? Evidence for the Convergent Evolution of Toxin Homologs in Three Species of Fireworms (Annelida, Amphinomidae). PMID:29293976
Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery. PMID:29215605
Alpha conotoxin-BuIA globular isomer is a competitive antagonist for oleoyl-L-alpha-lysophosphatidic acid binding to LPAR6; A molecular dynamics study. PMID:29211777
KNOTTIN: the database of inhibitor cystine knot scaffold after 10 years, toward a systematic structure modeling. PMID:29136213
Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (CaV) Channels. PMID:29027927
Recent Advances in Conotoxin Classification by Using Machine Learning Methods. PMID:28672838
From Marine Venoms to Drugs: Efficiently Supported by a Combination of Transcriptomics and Proteomics. PMID:28358320
Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. PMID:27801785
From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins. PMID:27104567
High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing. PMID:27087938
Characterization and Recombinant Expression of Terebrid Venom Peptide from Terebra guttata. PMID:26950153
Glycine-rich conotoxins from the Virgiconus clade. PMID:26851775
Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. PMID:26170295
Bioinformatics-Aided Venomics. PMID:26110505
αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors. PMID:26074268
Molecular Diversity and Gene Evolution of the Venom Arsenal of Terebridae Predatory Marine Snails. PMID:26025559
Discovery, synthesis, and structure-activity relationships of conotoxins. PMID:24720541
Sample limited characterization of a novel disulfide-rich venom peptide toxin from terebrid marine snail Terebra variegata. PMID:24713808
Influence of disulfide connectivity on structure and bioactivity of α-conotoxin TxIA. PMID:24434670
A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors. PMID:24398291
Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. PMID:24131469
In silico approach for predicting toxicity of peptides and proteins. PMID:24058508
Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. PMID:24043424
Short toxin-like proteins attack the defense line of innate immunity. PMID:23881252
A Conus regularis conotoxin with a novel eight-cysteine framework inhibits CaV2.2 channels and displays an anti-nociceptive activity. PMID:23567319
α -RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom. PMID:23533449
A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico. PMID:23474143
Glycosylation of conotoxins. PMID:23455513
A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily. PMID:23382933
Scorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering. PMID:23202307
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. PMID:23152539
Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct. PMID:22742208
Constrained de novo sequencing of conotoxins. PMID:22709442
A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily. PMID:22399292
Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels. PMID:22091786
Neurotoxins and their binding areas on voltage-gated sodium channels. PMID:22084632
Animal Toxins: How is Complexity Represented in Databases? PMID:22069583
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. PMID:22058133
A novel conotoxin, qc16a, with a unique cysteine framework and folding. PMID:21524672
Characterization of the Conus bullatus genome and its venom-duct transcriptome. PMID:21266071
Diversity of conotoxin types from Conus californicus reflects a diversity of prey types and a novel evolutionary history. PMID:21172372
ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures. PMID:21036864
A new subfamily of conotoxins belonging to the A-superfamily. PMID:20691232
Proteomic analysis provides insights on venom processing in Conus textile. PMID:20334424
Use of venom peptides to probe ion channel structure and function. PMID:20189991
The M-superfamily of conotoxins: a review. PMID:19705062
ArachnoServer: a database of protein toxins from spiders. PMID:19674480
Rapid sensitive analysis of cysteine rich peptide venom components. PMID:19380747
Peptide pal9a from the venom of the turrid snail Polystira albida from the Gulf of Mexico: purification, characterization, and comparison with P-conotoxin-like (framework IX) conoidean peptides. PMID:18948154
Integrating the discovery pipeline for novel compounds targeting ion channels. PMID:18678277 -
Conopeptide characterization and classifications: an analysis using ConoServer
PubMed citations: 88.
88 articles citing: Conopeptide characterization and classifications: an analysis using ConoServer
Unusual Post-Translational Modifications in the Biosynthesis of Lasso Peptides. PMID:35806232
Pathophysiological Responses to Conotoxin Modulation of Voltage-Gated Ion Currents. PMID:35621933
Preparation and Functional Identification of a Novel Conotoxin QcMNCL-XIII0.1 from Conus quercinus. PMID:35202127
Biomedical Potential of the Neglected Molluscivorous and Vermivorous Conus Species. PMID:35200635
Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers. PMID:35167877
Neglected Venomous Animals and Toxins: Underrated Biotechnological Tools in Drug Development. PMID:34941689
Antimicrobial Peptides from Plants: A cDNA-Library Based Isolation, Purification, Characterization Approach and Elucidating Their Modes of Action. PMID:34445412
Hormone-like conopeptides - new tools for pharmaceutical design. PMID:34095838
The genome of the venomous snail Lautoconus ventricosus sheds light on the origin of conotoxin diversity. PMID:34037232
Proteogenomic Assessment of Intraspecific Venom Variability: Molecular Adaptations in the Venom Arsenal of Conus purpurascens. PMID:34029722
Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus bayani as Determined from Transcriptomic and Proteomic Analyses. PMID:33916793
Combined Proteotranscriptomic-Based Strategy to Discover Novel Antimicrobial Peptides from Cone Snails. PMID:33805497
The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus. PMID:33619264
Identification of Conomarphin Variants in the Conus eburneus Venom and the Effect of Sequence and PTM Variations on Conomarphin Conformations. PMID:33019526
Plant Antimicrobial Peptides: State of the Art, In Silico Prediction and Perspectives in the Omics Era. PMID:32952397
Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus. PMID:32937857
Recent advances in the biosynthesis of RiPPs from multicore-containing precursor peptides. PMID:32617877
Comparative transcriptomics of the venoms of continental and insular radiations of West African cones. PMID:32546094
Graph-Directed Approach for Downselecting Toxins for Experimental Structure Determination. PMID:32422972
Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors. PMID:32234761
Insertions and Deletions Play an Important Role in the Diversity of Conotoxins. PMID:32170561
Selecting Potential Neuronal Drug Leads from Conotoxins of Various Venomous Marine Cone Snails in Bali, Indonesia. PMID:31763573
Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus. PMID:31661832
Conotoxin Diversity in the Venom Gland Transcriptome of the Magician's Cone, Pionoconus magus. PMID:31569823
Transcriptomic Analysis of Marine Gastropod Hemifusus tuba Provides Novel Insights into Conotoxin Genes. PMID:31405144
Structural and Functional Analyses of Cone Snail Toxins. PMID:31234371
Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR. PMID:31214027
The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework. PMID:30975904
High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing. PMID:30917600
Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis. PMID:30893765
Snails In Silico: A Review of Computational Studies on the Conopeptides. PMID:30832207
Lack of Signal for the Impact of Conotoxin Gene Diversity on Speciation Rates in Cone Snails. PMID:30816949
Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, Conus tulipa. PMID:30669642
High Throughput Identification of Novel Conotoxins from the Vermivorous Oak Cone Snail (Conus quercinus) by Transcriptome Sequencing. PMID:30563163
Discovery of Novel Conotoxin Candidates Using Machine Learning. PMID:30513724
Conotoxin Diversity in Chelyconus ermineus (Born, 1778) and the Convergent Origin of Piscivory in the Atlantic and Indo-Pacific Cones. PMID:30060147
Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods. PMID:29621159
Targeted Sequencing of Venom Genes from Cone Snail Genomes Improves Understanding of Conotoxin Molecular Evolution. PMID:29514313
Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes. PMID:29360782
A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity. PMID:29343689
Aqueous ionic liquids influence the disulfide bond isoform equilibrium in conotoxin AuIB: a consequence of the Hofmeister effect? PMID:29294259
Structural plasticity of mini-M conotoxins - expression of all mini-M subtypes by Conus regius. PMID:29283511
Sensitive Detection of α-Conotoxin GI in Human Plasma Using a Solid-Phase Extraction Column and LC-MS/MS. PMID:28788055
A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus). PMID:28718820
Recent Advances in Conotoxin Classification by Using Machine Learning Methods. PMID:28672838
The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea. PMID:28531118
From Marine Venoms to Drugs: Efficiently Supported by a Combination of Transcriptomics and Proteomics. PMID:28358320
Small Packages, Big Returns: Uncovering the Venom Diversity of Small Invertebrate Conoidean Snails. PMID:27371389
Dietary breadth is positively correlated with venom complexity in cone snails. PMID:27229931
From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins. PMID:27104567
Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. PMID:27093300
High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing. PMID:27087938
In Silico Identification of Protein Disulfide Isomerase Gene Families in the De Novo Assembled Transcriptomes of Four Different Species of the Genus Conus. PMID:26859138
Bioactive Mimetics of Conotoxins and other Venom Peptides. PMID:26501323
Identification and Characterization of a Novel Family of Cysteine-Rich Peptides (MgCRP-I) from Mytilus galloprovincialis. PMID:26201648
Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. PMID:26170295
Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks. PMID:26150494
Bioinformatics-Aided Venomics. PMID:26110505
Comparison of the Venom Peptides and Their Expression in Closely Related Conus Species: Insights into Adaptive Post-speciation Evolution of Conus Exogenomes. PMID:26047846
Molecular Diversity and Gene Evolution of the Venom Arsenal of Terebridae Predatory Marine Snails. PMID:26025559
Comprehensive analysis of the venom gland transcriptome of the spider Dolomedes fimbriatus. PMID:25977780
Effects of geographical heterogeneity in species interactions on the evolution of venom genes. PMID:25788600
Conotoxin gene superfamilies. PMID:25522317
Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom. PMID:25464369
High conopeptide diversity in Conus tribblei revealed through analysis of venom duct transcriptome using two high-throughput sequencing platforms. PMID:25117477
Application of community phylogenetic approaches to understand gene expression: differential exploration of venom gene space in predatory marine gastropods. PMID:24903151
Discovery, synthesis, and structure-activity relationships of conotoxins. PMID:24720541
Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae. PMID:24505301
Molecular evolution and diversity of Conus peptide toxins, as revealed by gene structure and intron sequence analyses. PMID:24349297
Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. PMID:24131469
Various conotoxin diversifications revealed by a venomic study of Conus flavidus. PMID:24126141
Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. PMID:24043424
Conopeptides from Cape Verde Conus crotchii. PMID:23783403
α -RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom. PMID:23533449
A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico. PMID:23474143
Glycosylation of conotoxins. PMID:23455513
Scorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering. PMID:23202307
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. PMID:23152539
Molecular phylogeny, classification and evolution of conopeptides. PMID:22760645
ConoDictor: a tool for prediction of conopeptide superfamilies. PMID:22661581
Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels. PMID:22091786
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. PMID:22058133
Conotoxin protein classification using free scores of words and support vector machines. PMID:21619696
Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PMID:21390272
Diversity of conotoxin types from Conus californicus reflects a diversity of prey types and a novel evolutionary history. PMID:21172372
Genome mining for ribosomally synthesized natural products. PMID:21095156
Chemical synthesis and characterization of two α4/7-conotoxins. PMID:20801929
A novel approach for in vivo screening of toxins using the Drosophila Giant Fiber circuit. PMID:20723555 -
Chemical modification of conotoxins to improve stability and activity
PubMed citations: 28.
28 articles citing: Chemical modification of conotoxins to improve stability and activity
Hormone-like conopeptides - new tools for pharmaceutical design. PMID:34095838
Proteogenomic Assessment of Intraspecific Venom Variability: Molecular Adaptations in the Venom Arsenal of Conus purpurascens. PMID:34029722
Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. PMID:31234412
Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein. PMID:30326175
Role of CysI-CysIII Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors. PMID:30023726
Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor. PMID:29925760
Epimerization-free access to C-terminal cysteine peptide acids, carboxamides, secondary amides, and esters via complimentary strategies. PMID:29629104
Recent Advances in Conotoxin Classification by Using Machine Learning Methods. PMID:28672838
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds. PMID:27826319
PDB-Explorer: a web-based interactive map of the protein data bank in shape space. PMID:26493835
Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. PMID:26290113
From foe to friend: using animal toxins to investigate ion channel function. PMID:25088688
Discovery, synthesis, and structure-activity relationships of conotoxins. PMID:24720541
Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels. PMID:24628243
Strategies for the development of conotoxins as new therapeutic leads. PMID:23812174
A Conus regularis conotoxin with a novel eight-cysteine framework inhibits CaV2.2 channels and displays an anti-nociceptive activity. PMID:23567319
P/Q-type calcium channel modulators. PMID:22670568
Receptor-targeting mechanisms of pain-causing toxins: How ow? PMID:22538196
Spider-venom peptides as therapeutics. PMID:22069579
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. PMID:22058133
Conotoxin protein classification using free scores of words and support vector machines. PMID:21619696
Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PMID:21390272
NMR and protein structure in drug design: application to cyclotides and conotoxins. PMID:21290122
Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor. PMID:20145249
Targeting voltage sensors in sodium channels with spider toxins. PMID:20097434
Characterization of a novel alpha4/4-conotoxin, Qc1.2, from vermivorous Conus quercinus. PMID:19779652
Integrating the discovery pipeline for novel compounds targeting ion channels. PMID:18678277
Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. PMID:18294843
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classification
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nucleic acid sequence
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protein structure
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sequence variant
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protein sequence databases
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databases of individual protein families
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small molecules
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nucleic acid sequence
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peptide
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protein
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protein structure
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sequence variant
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polypeptide_region
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protein sequence databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
databases of individual protein families
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
small molecules
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:32:33.962827
classification nucleic acid sequence patent peptide protein protein structure sequence variant polypeptide region protein sequence protein family small molecule
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