PROtein-protein compleX MutAtion ThErmodynamics Database

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PROtein-protein compleX MutAtion ThErmodynamics Database

metasource: Fairsharing.org
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PROXiMATE

metasource: Fairsharing.org
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Other names: PROXiMATE

PROXiMATE is a database of thermodynamic data for more than 6000 missense mutations in 174 heterodimeric protein-protein complexes, supplemented with interaction network data from STRING database, solvent accessibility, sequence, structural and functional information, experimental conditions and literature information. Additional features include complex structure visualization, search and display options, download options and a provision for users to upload their data.

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PROXiMATE: a database of mutant protein-protein complex thermodynamics and kinetics
PMID: 28498885

metasource: Fairsharing.org
version: None

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• PROXiMATE: a database of mutant protein-protein complex thermodynamics and kinetics PubMed citations: 15.

  15 articles citing: PROXiMATE: a database of mutant protein-protein complex thermodynamics and kinetics

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  Modern drug discovery applications for the identification of novel candidates for COVID-19 infections. PMID:35845863

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  Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies. PMID:35293269

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  Implications of disease-related mutations at protein-protein interfaces. PMID:34959033

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  Revealing the Threat of Emerging SARS-CoV-2 Mutations to Antibody Therapies. PMID:34273397

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  A topology-based network tree for the prediction of protein-protein binding affinity changes following mutation. PMID:34170981

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  Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, India, and other COVID-19-devastated countries. PMID:34004284

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  mmCSM-PPI: predicting the effects of multiple point mutations on protein-protein interactions. PMID:33893812

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  SAAMBE-SEQ: a sequence-based method for predicting mutation effect on protein-protein binding affinity. PMID:32866236

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  mmCSM-AB: guiding rational antibody engineering through multiple point mutations. PMID:32432715

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  SAAMBE-3D: Predicting Effect of Mutations on Protein-Protein Interactions. PMID:32272725

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  mCSM-PPI2: predicting the effects of mutations on protein-protein interactions. PMID:31114883

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  SKEMPI 2.0: an updated benchmark of changes in protein-protein binding energy, kinetics and thermodynamics upon mutation. PMID:30020414

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  AntiTbPdb: a knowledgebase of anti-tubercular peptides. PMID:29688365

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  ProtaBank: A repository for protein design and engineering data. PMID:29575358

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  Systems Bioinformatics: increasing precision of computational diagnostics and therapeutics through network-based approaches. PMID:29186305

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computational predictions

metasource: Fairsharing.org
version: None

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high-throughput screening

metasource: Fairsharing.org
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molecular structure

metasource: Fairsharing.org
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mutation

metasource: Fairsharing.org
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protein interaction

metasource: Fairsharing.org
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protein structure

metasource: Fairsharing.org
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protein-containing complex

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structure

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computational predictions high-throughput screening molecular structure mutation protein interaction protein structure protein-containing complex structure