LAMP

Other names: lamp

The Library of Apicomplexan Metabolic Pathways (LAMP, http://www.llamp.net) is a web database that provides near complete mapping from genes to the central metabolic functions for some of the prominent intracellular parasites of the phylum Apicomplexa. We have systematically assigned genes to functions within pathways/networks for Toxoplasma gondii, Neospora caninum, Cryptosporidium and Theileria species, and Babesia bovis. Several functions missing from pathways have been identified, where the corresponding gene for an essential process appears to be absent from the current genome annotation. There had been extensive manual curation carried out for these species (especially T. gondii) with the use of available experimental data from publications and the genome database EuPathDB (3). For each species, LAMP contains interactive diagrams of each pathway, hyperlinked to external resources and annotated with detailed information, including the sources of evidence used. We have also developed a section to highlight the overall metabolic capabilities of each species, such as the ability to synthesise or the dependence upon the host for a particular metabolite. We are also expecting to include the annotations and metabolic pathways for other apicomplexans, when the genomes become available. As a recent development, the annotations of LAMP have been linked out from the respective gene pages from the beta release of ToxoDB version 8.0, and are expected to be part of the full release (4). We expect that LAMP will be a valuable resource for fundamental and applied research on the Apicomplexa.

Webpage:
http://www.llamp.net

Publications:

Tags:

metabolic and signaling pathways metabolic and signaling pathways microbiology toxicology drug development

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