FAIRsharing.k6vsdr; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:08 p.m.

metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:35.495967

syfpeithi
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:35.495967

Other names: SYFPEITHI, syfpeithi

SYFPEITHI is a database comprising more than 7000 peptide sequences known to bind class I and class II MHC molecules.

Webpage:

http://www.syfpeithi.de/

Publications:

Publications
More detailed information about this field from each metasource.

SYFPEITHI: database for MHC ligands and peptide motifs
PMID: 10602881
metasource: Fairsharing.org
version: FAIRsharing.org: SYFPEITHI; Database of MHC Ligands and Peptide Motifs; DOI: https://doi.org/10.25504/FAIRsharing.k6vsdr; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:08 p.m.

metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:35.495967

SYFPEITHI: database for MHC ligands and peptide motifs PubMed citations: 788.

788 articles citing: SYFPEITHI: database for MHC ligands and peptide motifs

CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns. PMID:35918315
DeepMHCII: a novel binding core-aware deep interaction model for accurate MHC-II peptide binding affinity prediction. PMID:35758790
Prediction of Major Histocompatibility Complex Binding with Bilateral and Variable Long Short Term Memory Networks. PMID:35741369
Mapping immunogenic epitopes of an adhesin-like protein from Methanobrevibacter ruminantium M1 and comparison of empirical data with in silico prediction methods. PMID:35729277
SARS-CoV-2 Omicron Variant is Expected to Retain Most of the Spike Protein Specific Dominant T-Cell Epitopes Presented by COVID-19 Vaccines - Worldwide, 2021. PMID:35686202
Designing of multi-epitope chimeric vaccine using immunoinformatic platform by targeting oncogenic strain HPV 16 and 18 against cervical cancer. PMID:35681036
Non-Mutated Nucleophosmin 1 Is Recognized by the CD8+ T Lymphocytes of an AML Patient after the Transplantation of Hematopoietic Stem Cells from an HLA-Haploidentical Donor. PMID:35621629
Antigen Presentation in the Lung. PMID:35615351
Vaccines and Immunoinformatics for Vaccine Design. PMID:35594022
The Use of Molecular Dynamics Simulation Method to Quantitatively Evaluate the Affinity between HBV Antigen T Cell Epitope Peptides and HLA-A Molecules. PMID:35563019
Vaccine Can Induce CD4-Mediated Responses to Homocitrullinated Peptides via Multiple HLA-Types and Confer Anti-Tumor Immunity. PMID:35464453
The Importance of Being Presented: Target Validation by Immunopeptidomics for Epitope-Specific Immunotherapies. PMID:35464395
Comparative Immunoreactivity Analyses of Hantaan Virus Glycoprotein-Derived MHC-I Epitopes in Vaccination. PMID:35455313
Cancer Neoantigens: Challenges and Future Directions for Prediction, Prioritization, and Validation. PMID:35311072
Machine Learning Techniques for the Prediction of B-Cell and T-Cell Epitopes as Potential Vaccine Targets with a Specific Focus on SARS-CoV-2 Pathogen: A Review. PMID:35215090
Design of a Novel Recombinant Multi-Epitope Vaccine against Triple-Negative Breast Cancer. PMID:35090304
Antitumor Peptide-Based Vaccine in the Limelight. PMID:35062731
Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma. PMID:35003900
Identification of Claudin 6-specific HLA class I- and HLA class II-restricted T cell receptors for cellular immunotherapy in ovarian cancer. PMID:35003898
Epitope-Based Vaccine of a Brucella abortus Putative Small RNA Target Induces Protection and Less Tissue Damage in Mice. PMID:34992597
Identification of HLA-A*24:02-Restricted CTL Candidate Epitopes Derived from the Nonstructural Polyprotein 1a of SARS-CoV-2 and Analysis of Their Conservation Using the Mutation Database of SARS-CoV-2 Variants. PMID:34937174
Adoptive Cell Transfer of Allogeneic Epstein-Barr Virus-Specific T Lymphocytes for Treatment of Refractory EBV-Associated Posttransplant Smooth Muscle Tumors: A Case Report. PMID:34925312
Engineering a multi-epitope vaccine candidate against Leishmania infantum using comprehensive Immunoinformatics methods. PMID:34866641
Identification of an Immunogenic Medulloblastoma-Specific Fusion Involving EPC2 and GULP1. PMID:34830991
Synthetic vaccine affords full protection to mice against lethal challenge of influenza B virus of both genetic lineages. PMID:34805790
MHC-Optimized Peptide Scaffold for Improved Antigen Presentation and Anti-Tumor Response. PMID:34745146
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. PMID:34729465
Novel HLA-B7-restricted human metapneumovirus epitopes enhance viral clearance in mice and are recognized by human CD8+ T cells. PMID:34675220
Acid Stripping after Infection Improves the Detection of Viral HLA Class I Natural Ligands Identified by Mass Spectrometry. PMID:34638844
T Cell Epitope Prediction and Its Application to Immunotherapy. PMID:34603286
The pockets guide to HLA class I molecules. PMID:34581761
Antigen-specific immunotherapy with apitopes suppresses generation of FVIII inhibitor antibodies in HLA-transgenic mice. PMID:34529764
Peptipedia: a user-friendly web application and a comprehensive database for peptide research supported by Machine Learning approach. PMID:34478499
Vaccine Design and Vaccination Strategies against Rickettsiae. PMID:34452021
Identification and Targeting of Mutant Peptide Neoantigens in Cancer Immunotherapy. PMID:34439399
Prospective Evaluation of Radiotherapy-Induced Immunologic and Genetic Effects in Colorectal Cancer Oligo-Metastatic Patients with Lung-Limited Disease: The PRELUDE-1 Study. PMID:34439390
Mechanisms of Immunotoxicity: Stressors and Evaluators. PMID:34361007
Broad and Efficient Activation of Memory CD4+ T Cells by Novel HAdV- and HCMV-Derived Peptide Pools. PMID:34322126
Identification of mouse helper epitopes for WT1-specific CD4+ T cells. PMID:34272593
Immunogenomic determinants of tumor microenvironment correlate with superior survival in high-risk neuroblastoma. PMID:34272305
T Cell Specificity: A Great Challenge in Chagas Disease. PMID:34267750
A Novel HAGE/WT1-ImmunoBody® Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone. PMID:34262856
Recent progress on MHC-I epitope prediction in tumor immunotherapy. PMID:34249407
ERAP1 binds peptide C-termini of different sequences and/or lengths by a common recognition mechanism. PMID:34247019
Computational identification and characterization of antigenic properties of Rv3899c of Mycobacterium tuberculosis and its interaction with human leukocyte antigen (HLA). PMID:34228167
CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients. PMID:34210785
Predicting MHC class I binder: existing approaches and a novel recurrent neural network solution. PMID:34131696
Deciphering Human Leukocyte Antigen Susceptibility Maps From Immunopeptidomics Characterization in Oncology and Infections. PMID:34123866
Unique Pathogen Peptidomes Facilitate Pathogen-Specific Selection and Specialization of MHC Alleles. PMID:34110412
Infectious disease mRNA vaccines and a review on epitope prediction for vaccine design. PMID:34089044
Landscape of epitopes targeted by T cells in 852 individuals recovered from COVID-19: Meta-analysis, immunoprevalence, and web platform. PMID:34056627
Designing a SARS-CoV-2 T-Cell-Inducing Vaccine for High-Risk Patient Groups. PMID:33923363
A Mouse Model of PPRV Infection for Elucidating Protective and Pathological Roles of Immune Cells. PMID:33912160
Genetics of HLA Peptide Presentation and Impact on Outcomes in HLA-Matched Allogeneic Hematopoietic Cell Transplantation. PMID:33882342
Whole genome deep sequencing analysis of viral quasispecies diversity and evolution in HBeAg seroconverters. PMID:33870157
Screening for Mycobacterium tuberculosis Infection Using Beijing/K Strain-Specific Peptides in a School Outbreak Cohort. PMID:33869073
Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery. PMID:33866408
HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy. PMID:33858848
Advanced strategies for development of vaccines against human bacterial pathogens. PMID:33748926
Vaccinomics approach for scheming potential epitope-based peptide vaccine by targeting l-protein of Marburg virus. PMID:33717824
Identification and characterization of heteroclitic peptides in TCR-binding positions with improved HLA-binding efficacy. PMID:33637105
The Peptide Vaccine of the Future. PMID:33583769
Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy. PMID:33537173
T Cell Peptides Derived from Invasive Stages of Schistosoma mansoni as Potential Schistosomiasis Vaccine. PMID:33498845
Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis. PMID:33490292
Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma. PMID:33457076
Deimmunization of protein therapeutics - Recent advances in experimental and computational epitope prediction and deletion. PMID:33425259
In silico design of multi-epitope-based peptide vaccine against SARS-CoV-2 using its spike protein. PMID:33403946
MHCII3D-Robust Structure Based Prediction of MHC II Binding Peptides. PMID:33374958
Identification of HLA-A*02:01-restricted candidate epitopes derived from the non-structural polyprotein 1a of SARS-CoV-2 that may be natural targets of CD8+ T cell recognition in vivo. PMID:33268522
SITC cancer immunotherapy resource document: a compass in the land of biomarker discovery. PMID:33268350
Cytotoxic T-lymphocyte elicited therapeutic vaccine candidate targeting cancer against MAGE-A11 carcinogenic protein. PMID:33169789
Mild Acid Elution and MHC Immunoaffinity Chromatography Reveal Similar Albeit Not Identical Profiles of the HLA Class I Immunopeptidome. PMID:33141586
POTN: A Human Leukocyte Antigen-A2 Immunogenic Peptides Screening Model and Its Applications in Tumor Antigens Prediction. PMID:33133063
The neglected challenge: Vaccination against rickettsiae. PMID:33091016
TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals. PMID:33013822
In silico analysis and in vivo assessment of a novel epitope-based vaccine candidate against uropathogenic Escherichia coli. PMID:33004862
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition. PMID:32999467
MMP-7 derived peptides with MHC class-I binding motifs from canine mammary tumor tissue elicit strong antigen-specific T-cell responses in BALB/c mice. PMID:32970284
Point mutation screening of tumor neoantigens and peptide-induced specific cytotoxic T lymphocytes using The Cancer Genome Atlas database. PMID:32934692
Repertoire-scale determination of class II MHC peptide binding via yeast display improves antigen prediction. PMID:32887877
Combining Three-Dimensional Modeling with Artificial Intelligence to Increase Specificity and Precision in Peptide-MHC Binding Predictions. PMID:32878910
Progress in Neoantigen Targeted Cancer Immunotherapies. PMID:32850843
Vaccine candidate designed against carcinoembryonic antigen-related cell adhesion molecules using immunoinformatics tools. PMID:32720576
Towards new horizons: characterization, classification and implications of the tumour antigenic repertoire. PMID:32572208
Impact of Cysteine Residues on MHC Binding Predictions and Recognition by Tumor-Reactive T Cells. PMID:32571843
Distinctive germline expression of class I human leukocyte antigen (HLA) alleles and DRB1 heterozygosis predict the outcome of patients with non-small cell lung cancer receiving PD-1/PD-L1 immune checkpoint blockade. PMID:32554614
Benchmarking predictions of MHC class I restricted T cell epitopes in a comprehensively studied model system. PMID:32453790
Experimental Antiglomerular Basement Membrane GN Induced by a Peptide from Actinomyces. PMID:32444356
Radiation-induced small extracellular vesicles as "carriages" promote tumor antigen release and trigger antitumor immunity. PMID:32308755
Immunization against ROS1 by DNA Electroporation Impairs K-Ras-Driven Lung Adenocarcinomas . PMID:32268572
Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2). PMID:32265295
Immunogenicity and Immune Silence in Human Cancer. PMID:32256484
In silico design of a T-cell epitope vaccine candidate for parasitic helminth infection. PMID:32203551
Cancer testis antigen Cyclin A1 harbors several HLA-A*02:01-restricted T cell epitopes, which are presented and recognized in vivo. PMID:32157447
Tumor-Specific T Cell Activation in Malignant Brain Tumors. PMID:32117316
dbPepNeo: a manually curated database for human tumor neoantigen peptides. PMID:32090262
Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy. PMID:31932876
Identification of HCMV-derived T cell epitopes in seropositive individuals through viral deletion models. PMID:31869419
A large peptidome dataset improves HLA class I epitope prediction across most of the human population. PMID:31844290
A Non-interventional Clinical Trial Assessing Immune Responses After Radiofrequency Ablation of Liver Metastases From Colorectal Cancer. PMID:31803175
Machine Learning for Cancer Immunotherapies Based on Epitope Recognition by T Cell Receptors. PMID:31798635
T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients. PMID:31741759
Peptides Derived of Kunitz-Type Serine Protease Inhibitor as Potential Vaccine Against Experimental Schistosomiasis. PMID:31736947
HLA-F Allele-Specific Peptide Restriction Represents an Exceptional Proteomic Footprint. PMID:31717259
TCR Fingerprinting and Off-Target Peptide Identification. PMID:31695703
In silico/In vivo analysis of high-risk papillomavirus L1 and L2 conserved sequences for development of cross-subtype prophylactic vaccine. PMID:31645650
Developing neoantigen-targeted T cell-based treatments for solid tumors. PMID:31591590
HLA class I-restricted T cell epitopes isolated and identified from myeloid leukemia cells. PMID:31575892
Structure Based Prediction of Neoantigen Immunogenicity. PMID:31555277
Autoimmunity (or Not) in Atopic Dermatitis. PMID:31552053
Ligandomes obtained from different HLA-class II-molecules are homologous for N- and C-terminal residues outside the peptide-binding cleft. PMID:31520135
A transplantable tumor model allowing investigation of NY-BR-1-specific T cell responses in HLA-DRB1*0401 transgenic mice. PMID:31519152
Computational approaches for characterizing the tumor immune microenvironment. PMID:31347163
Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer. PMID:31316521
Immunoproteomic analysis of a Chikungunya poxvirus-based vaccine reveals high HLA class II immunoprevalence. PMID:31276466
PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma. PMID:31221178
A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction. PMID:31204427
Mass spectrometry-based identification of MHC-bound peptides for immunopeptidomics. PMID:31092913
Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma. PMID:31039795
A library of Neo Open Reading Frame peptides (NOPs) as a sustainable resource of common neoantigens in up to 50% of cancer patients. PMID:31036835
Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes. PMID:31015529
Targeting self and neo-epitopes with a modular self-adjuvanting cancer vaccine. PMID:31013258
Identification of CD4 and H-2Kd-restricted cytotoxic T lymphocyte epitopes on the human herpesvirus 6B glycoprotein Q1 protein. PMID:30846739
Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors. PMID:30835255
Pro-inflammatory Cytokines Alter the Immunopeptidome Landscape by Modulation of HLA-B Expression. PMID:30833945
Naturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetes. PMID:30817223
Conserved peptide vaccine candidates containing multiple Ebola nucleoprotein epitopes display interactions with diverse HLA molecules. PMID:30790057
Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8+ T Cells and Evolve at the Population Level. PMID:30768983
DeepSeqPan, a novel deep convolutional neural network model for pan-specific class I HLA-peptide binding affinity prediction. PMID:30692623
Perspective: The promises of a holistic view of proteins-impact on antibody engineering and drug discovery. PMID:30630879
Structure-based Methods for Binding Mode and Binding Affinity Prediction for Peptide-MHC Complexes. PMID:30582480
Broad CD8+ T cell cross-recognition of distinct influenza A strains in humans. PMID:30575715
A Review on T Cell Epitopes Identified Using Prediction and Cell-Mediated Immune Models for Mycobacterium tuberculosis and Bordetella pertussis. PMID:30555469
Identification of a First Human Norovirus CD8+ T Cell Epitope Restricted to HLA-A*0201 Allele. PMID:30542352
Long-peptide vaccination with driver gene mutations in p53 and Kras induces cancer mutation-specific effector as well as regulatory T cell responses. PMID:30524892
Personalized identification of tumor-associated immunogenic neoepitopes in hepatocellular carcinoma in complete remission after sorafenib treatment. PMID:30459932
High-Throughput Stability Screening of Neoantigen/HLA Complexes Improves Immunogenicity Predictions. PMID:30425106
Prediction of Antimicrobial Potential of a Chemically Modified Peptide From Its Tertiary Structure. PMID:30416494
Systematically benchmarking peptide-MHC binding predictors: From synthetic to naturally processed epitopes. PMID:30408041
A comprehensive in silico analysis for identification of therapeutic epitopes in HPV16, 18, 31 and 45 oncoproteins. PMID:30356257
Contribution of the plasma and lymph Degradome and Peptidome to the MHC Ligandome. PMID:30343358
Identification of a Shared Cytochrome p4502E1 Epitope Found in Anesthetic Drug-Induced and Viral Hepatitis. PMID:30305319
DNA prime-protein boost vaccine encoding HLA-A2, HLA-A24 and HLA-DR1 restricted epitopes of CaNA2 against visceral leishmaniasis. PMID:30285279
RNA editing derived epitopes function as cancer antigens to elicit immune responses. PMID:30254248
Breast cancer vaccination comes to age: impacts of bioinformatics. PMID:30211082
Plasmodium vivax Pv12 B-cell epitopes and HLA-DRβ1*-dependent T-cell epitopes in vitro antigenicity. PMID:30199554
Predicting Antigen Presentation-What Could We Learn From a Million Peptides? PMID:30090105
CD8+ Cytotoxic T Lymphocyte Responses and Viral Epitope Escape in Acute HIV-1 Infection. PMID:30059271
In vivo and in vitro immunogenicity of novel MHC class I presented epitopes to confer protective immunity against chronic HTLV-1 infection. PMID:30005946
Impact of Leishmania donovani infection on the HLA I self peptide repertoire of human macrophages. PMID:30001391
In silico and ex vivo approaches indicate immune pressure on capsid and non-capsid regions of coxsackie B viruses in the human system. PMID:29924875
Optimized dendritic cell vaccination induces potent CD8 T cell responses and anti-tumor effects in transgenic mouse melanoma models. PMID:29900058
Postgenomic Approaches and Bioinformatics Tools to Advance the Development of Vaccines against Bacteria of the Burkholderia cepacia Complex. PMID:29890657
Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation. PMID:29789417
Nature of tumour rejection antigens in ovarian cancer. PMID:29772069
Characterization of a Trichinella spiralis putative serine protease. Study of its potential as sero-diagnostic tool. PMID:29758030
Cross-sectional analysis of CD8 T cell immunity to human herpesvirus 6B. PMID:29698478
Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8+ T Cells. PMID:29669837
Mapping the tumour human leukocyte antigen (HLA) ligandome by mass spectrometry. PMID:29658117
A Targeted LC-MS Strategy for Low-Abundant HLA Class-I-Presented Peptide Detection Identifies Novel Human Papillomavirus T-Cell Epitopes. PMID:29603667
Trypanosoma cruzi 80 kDa prolyl oligopeptidase (Tc80) as a novel immunogen for Chagas disease vaccine. PMID:29601585
Identification of an HLA-A2-restricted CD147 epitope that can induce specific CTL cytotoxicity against drug resistant MCF-7/Adr cells. PMID:29556319
Current progress of immunoinformatics approach harnessed for cellular- and antibody-dependent vaccine design. PMID:29528265
Immunodominance in T cell responses elicited against different domains of detoxified pneumolysin PlyD1. PMID:29509778
Translating Immunopeptidomics to Immunotherapy-Decision-Making for Patient and Personalized Target Selection. PMID:29505699
Fundamentals and Methods for T- and B-Cell Epitope Prediction. PMID:29445754
FVIII proteins with a modified immunodominant T-cell epitope exhibit reduced immunogenicity and normal FVIII activity. PMID:29444872
Personalized adoptive immunotherapy for patients with EBV-associated tumors and complications: Evaluation of novel naturally processed and presented EBV-derived T-cell epitopes. PMID:29435138
Identification of a Novel CD8 T Cell Epitope Derived from Plasmodium berghei Protective Liver-Stage Antigen. PMID:29434602
Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: a case report. PMID:29409514
Analysis of viral diversity for vaccine target discovery. PMID:29322922
The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis. PMID:29317506
The Role of Mass Spectrometry and Proteogenomics in the Advancement of HLA Epitope Prediction. PMID:29314742
Membranal and Blood-Soluble HLA Class II Peptidome Analyses Using Data-Dependent and Independent Acquisition. PMID:29314611
Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/Kb Transgenic Mice May Associate with the Severity of Hemorrhagic Fever with Renal Syndrome. PMID:29312318
Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes. PMID:29275860
Longevity of antibody and T-cell responses against outer membrane antigens of Orientia tsutsugamushi in scrub typhus patients. PMID:29259327
Preclinical and clinical development of neoantigen vaccines. PMID:29253113
Synthetic peptides mimicking lipopolysaccharide as a potential vaccine candidates against Vibrio cholerae serogroup O1. PMID:29238460
The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes. PMID:29203182
Vaccination with recombinant adenovirus expressing peste des petits ruminants virus-F or -H proteins elicits T cell responses to epitopes that arises during PPRV infection. PMID:29157291
BRAF peptide vaccine facilitates therapy of murine BRAF-mutant melanoma. PMID:29094184
Vaccinomics Approach for Designing Potential Peptide Vaccine by Targeting Shigella spp. Serine Protease Autotransporter Subfamily Protein SigA. PMID:29082265
CD4 and CD8 T lymphocyte interplay in controlling tumor growth. PMID:29032503
Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency. PMID:28894200
Human Leukocyte Antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 Present Complementary Peptide Repertoires. PMID:28871256
Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity. PMID:28832583
Tools to define the melanoma-associated immunopeptidome. PMID:28755382
Sharpening the Edge for Precision Cancer Immunotherapy: Targeting Tumor Antigens through Oncolytic Vaccines. PMID:28751892
A computational pipeline to generate MHC binding motifs. PMID:28747991
The Role of Multiscale Protein Dynamics in Antigen Presentation and T Lymphocyte Recognition. PMID:28740497
A Poly(Lactic-co-Glycolic) Acid Nanovaccine Based on Chimeric Peptides from Different Leishmania infantum Proteins Induces Dendritic Cells Maturation and Promotes Peptide-Specific IFNγ-Producing CD8+ T Cells Essential for the Protection against Experimental Visceral Leishmaniasis. PMID:28659922
NOG-hIL-4-Tg, a new humanized mouse model for producing tumor antigen-specific IgG antibody by peptide vaccination. PMID:28617827
HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses. PMID:28533942
Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8+ T-cell Recognition of a Retroviral Antigen. PMID:28484076
ImmunoNodes - graphical development of complex immunoinformatics workflows. PMID:28482806
Citrullination only infrequently impacts peptide binding to HLA class II MHC. PMID:28481943
Bioinformatic prediction of the epitopes of Echinococcus granulosus antigen 5. PMID:28357070
The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design. PMID:28352270
Bonobos Maintain Immune System Diversity with Three Functional Types of MHC-B. PMID:28348269
The susceptible HLA class II alleles and their presenting epitope(s) in Goodpasture's disease. PMID:28342268
The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Formation of DSA. PMID:28331856
Sequence-based approach for rapid identification of cross-clade CD8+ T-cell vaccine candidates from all high-risk HPV strains. PMID:28330110
Peptide-binding motifs of two common equine class I MHC molecules in Thoroughbred horses. PMID:28315936
Autophagy and Autophagy-Related Proteins in CNS Autoimmunity. PMID:28289410
Targeting neoantigens to augment antitumour immunity. PMID:28233802
The elucidation of non-classical MHC class II antigen processing through the study of viral antigens. PMID:28081485
Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer. PMID:28031159
Structure of the transporter associated with antigen processing trapped by herpes simplex virus. PMID:27935481
MHC Class II Risk Alleles and Amino Acid Residues in Idiopathic Membranous Nephropathy. PMID:27852637
MHC class I-associated peptides derive from selective regions of the human genome. PMID:27841757
Identification of HLA‑A*1101‑restricted cytotoxic T lymphocyte epitopes derived from epidermal growth factor pathway substrate number 8. PMID:27840923
Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma. PMID:27837020
Crystal structure of a polypeptide's C-terminus in complex with the regulatory domain of ER aminopeptidase 1. PMID:27825049
Discovery of immunodominant T-cell epitopes reveals penton protein as a second immunodominant target in human adenovirus infection. PMID:27717382
Recent advances in T-cell engineering for use in immunotherapy. PMID:27703664
Current tools for predicting cancer-specific T cell immunity. PMID:27622028
Present Yourself! By MHC Class I and MHC Class II Molecules. PMID:27614798
Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes. PMID:27571370
sNebula, a network-based algorithm to predict binding between human leukocyte antigens and peptides. PMID:27558848
TepiTool: A Pipeline for Computational Prediction of T Cell Epitope Candidates. PMID:27479659
Optimizing Immunization Strategies for the Induction of Antigen-Specific CD4 and CD8 T Cell Responses for Protection against Intracellular Parasites. PMID:27466350
Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens. PMID:27447745
Computational genomics tools for dissecting tumour-immune cell interactions. PMID:27376489
A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cells. PMID:27347387
A Novel Peptide Binding Prediction Approach for HLA-DR Molecule Based on Sequence and Structural Information. PMID:27340658
In Silico Design of a Chimeric Protein Containing Antigenic Fragments of Helicobacter pylori; A Bioinformatic Approach. PMID:27335622
Human T cell responses to Japanese encephalitis virus in health and disease. PMID:27242166
HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection. PMID:27233953
Multiple sclerosis: Molecular mimicry of an antimyelin HLA class I restricted T-cell receptor. PMID:27231714
Development of Acquired Immunity following Repeated Respiratory Syncytial Virus Infections in Cotton Rats. PMID:27224021
Detection of vasostatin-1-specific CD8(+) T cells in non-obese diabetic mice that contribute to diabetes pathogenesis. PMID:27185276
Structural and Biochemical Analyses of Swine Major Histocompatibility Complex Class I Complexes and Prediction of the Epitope Map of Important Influenza A Virus Strains. PMID:27170754
Antimelanoma CTL recognizes peptides derived from an ORF transcribed from the antisense strand of the 3' untranslated region of TRIT1. PMID:27119099
How frequently are predicted peptides actually recognized by CD8 cells? PMID:27108305
Novel HLA-A2-restricted human metapneumovirus epitopes reduce viral titers in mice and are recognized by human T cells. PMID:27105560
Post-Genomics and Vaccine Improvement for Leishmania. PMID:27092123
Designing therapeutic cancer vaccines by mimicking viral infections. PMID:27052572
NetMHCpan-3.0; improved prediction of binding to MHC class I molecules integrating information from multiple receptor and peptide length datasets. PMID:27029192
Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model. PMID:27018595
Unmasking targets of antitumor immunity via high-throughput antigen profiling. PMID:27010105
The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer. PMID:26922999
Identification of Immunoreactive Leishmania infantum Protein Antigens to Asymptomatic Dog Sera through Combined Immunoproteomics and Bioinformatics Analysis. PMID:26906226
CD4+ T-cell epitope prediction using antigen processing constraints. PMID:26891811
A potent multivalent vaccine for modulation of immune system in atherosclerosis: an in silico approach. PMID:26866024
Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection. PMID:26858717
Translation from the 5' untranslated region shapes the integrated stress response. PMID:26823435
Designing string-of-beads vaccines with optimal spacers. PMID:26813686
Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review. PMID:26780035
Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease. PMID:26695135
Identification of Immunodominant Responses to the Plasmodium falciparum Antigens PfUIS3, PfLSA1 and PfLSAP2 in Multiple Strains of Mice. PMID:26659715
Analysis of Major Histocompatibility Complex (MHC) Immunopeptidomes Using Mass Spectrometry. PMID:26628741
A Simple Proteomics-Based Approach to Identification of Immunodominant Antigens from a Complex Pathogen: Application to the CD4 T Cell Response against Human Herpesvirus 6B. PMID:26599878
Immunoinformatics and epitope prediction in the age of genomic medicine. PMID:26589500
A combined prediction strategy increases identification of peptides bound with high affinity and stability to porcine MHC class I molecules SLA-1*04:01, SLA-2*04:01, and SLA-3*04:01. PMID:26572135
Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma. PMID:26536470
Gapped sequence alignment using artificial neural networks: application to the MHC class I system. PMID:26515819
Sequence conservation analysis and in silico human leukocyte antigen-peptide binding predictions for the Mtb72F and M72 tuberculosis candidate vaccine antigens. PMID:26493839
AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes. PMID:26445723
Endogenous Antigen Presentation of MHC Class II Epitopes through Non-Autophagic Pathways. PMID:26441969
Understanding and predicting binding between human leukocyte antigens (HLAs) and peptides by network analysis. PMID:26424483
The impact of HLA class I and EBV latency-II antigen-specific CD8(+) T cells on the pathogenesis of EBV(+) Hodgkin lymphoma. PMID:26422112
Localization of CD8 T cell epitope within cardiac myosin heavy chain-α334-352 that induces autoimmune myocarditis in A/J mice. PMID:26422020
Novel epitopes identified from efflux pumps of Mycobacterium tuberculosis could induce cytotoxic T lymphocyte response. PMID:26417538
Vaccination against type 1 angiotensin receptor prevents streptozotocin-induced diabetic nephropathy. PMID:26407577
Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules. PMID:26401003
Identification of Conserved Peptides Comprising Multiple T Cell Epitopes of Matrix 1 Protein in H1N1 Influenza Virus. PMID:26398199
Replication-Competent Foamy Virus Vaccine Vectors as Novel Epitope Scaffolds for Immunotherapy. PMID:26397953
Exploring peptide/MHC detachment processes using hierarchical natural move Monte Carlo. PMID:26395770
T cell epitopes and post-translationally modified epitopes in type 1 diabetes. PMID:26370701
Systems Biology Approach for Cancer Vaccine Development and Evaluation. PMID:26350594
Therapeutic Vaccine Strategies against Human Papillomavirus. PMID:26344626
Epitope Prediction Assays Combined with Validation Assays Strongly Narrows down Putative Cytotoxic T Lymphocyte Epitopes. PMID:26343185
CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer. PMID:26327325
The Carboxy Terminus of the Ligand Peptide Determines the Stability of the MHC Class I Molecule H-2Kb: A Combined Molecular Dynamics and Experimental Study. PMID:26270965
Tumor neoantigens: building a framework for personalized cancer immunotherapy. PMID:26258412
HLA-B polymorphisms and intracellular assembly modes. PMID:26239417
Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses. PMID:26112079
Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most? PMID:26040913
Identification of novel CD8+ T cell epitopes in human herpesvirus 6B U11 and U90. PMID:26029371
Accurate prediction of immunogenic T-cell epitopes from epitope sequences using the genetic algorithm-based ensemble learning. PMID:26020952
Signature Patterns of MHC Diversity in Three Gombe Communities of Wild Chimpanzees Reflect Fitness in Reproduction and Immune Defense against SIVcpz. PMID:26020813
Identification of Novel Potential Vaccine Candidates against Tuberculosis Based on Reverse Vaccinology. PMID:25961021
Molecular mimicry of MAGE-A6 and Mycoplasma penetrans HF-2 epitopes in the induction of antitumor CD8+ T-cell responses. PMID:25960935
Prediction of CD8+ Epitopes in Leishmania braziliensis Proteins Using EPIBOT: In Silico Search and In Vivo Validation. PMID:25905908
TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes. PMID:25831525
The HIV-1 antisense protein (ASP) induces CD8 T cell responses during chronic infection. PMID:25809376
Deciphering complex patterns of class-I HLA-peptide cross-reactivity via hierarchical grouping. PMID:25708537
Identification of Mycobacterium tuberculosis PPE68-specific HLA-A*0201-restricted epitopes for tuberculosis diagnosis. PMID:25682073
Discovering protective CD8 T cell epitopes--no single immunologic property predicts it! PMID:25660347
The viral transcription group determines the HLA class I cellular immune response against human respiratory syncytial virus. PMID:25635267
Mass spectrometry of human leukocyte antigen class I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation. PMID:25576301
Proximity ligation assay evaluates IDH1R132H presentation in gliomas. PMID:25555220
Antigen-specific vaccines for cancer treatment. PMID:25483639
Role of peptide processing predictions in T cell epitope identification: contribution of different prediction programs. PMID:25475908
Immunogenicity of Multi-Epitope DNA and Peptide Vaccine Candidates Based on Core, E2, NS3 and NS5B HCV Epitopes in BALB/c Mice. PMID:25419219
The Trypanosoma cruzi flagellum is discarded via asymmetric cell division following invasion and provides early targets for protective CD8⁺ T cells. PMID:25299330
A common minimal motif for the ligands of HLA-B*27 class I molecules. PMID:25268942
Computer aided prediction and identification of potential epitopes in the receptor binding domain (RBD) of spike (S) glycoprotein of MERS-CoV. PMID:25258490
Soluble HLA technology as a strategy to evaluate the impact of HLA mismatches. PMID:25254222
In Silico Design and Analysis of TGFαL3-SEB Fusion Protein as "a New Antitumor Agent" Candidate by Ligand-Targeted Superantigens Technique. PMID:25250167
Examining variable domain orientations in antigen receptors gives insight into TCR-like antibody design. PMID:25233457
Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes. PMID:25211344
Differential ion mobility spectrometry coupled to tandem mass spectrometry enables targeted leukemia antigen detection. PMID:25184817
A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins: part 2-model applications. PMID:25184734
In vitro and in vivo studies for assessing the immune response and protection-inducing ability conferred by Fasciola hepatica-derived synthetic peptides containing B- and T-cell epitopes. PMID:25122166
A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. PMID:25112375
Large scale characterization of the LC13 TCR and HLA-B8 structural landscape in reaction to 172 altered peptide ligands: a molecular dynamics simulation study. PMID:25101830
Compromised central tolerance of ICA69 induces multiple organ autoimmunity. PMID:25088457
Customized predictions of peptide-MHC binding and T-cell epitopes using EPIMHC. PMID:25048133
A vaccine targeting mutant IDH1 induces antitumour immunity. PMID:25043048
Peptide-dependent conformational fluctuation determines the stability of the human leukocyte antigen class I complex. PMID:25028510
Discovery of novel cross-protective Rickettsia prowazekii T-cell antigens using a combined reverse vaccinology and in vivo screening approach. PMID:25010827
MHC Class I Presented T Cell Epitopes as Potential Antigens for Therapeutic Vaccine against HBV Chronic Infection. PMID:24971174
A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets. PMID:24970476
Ontology-supported research on vaccine efficacy, safety and integrative biological networks. PMID:24909153
Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method. PMID:24905579
HLA-binding properties of tumor neoepitopes in humans. PMID:24894089
Predicting alloreactivity in transplantation. PMID:24868561
Low level of HIV-1 evolution after transmission from mother to child. PMID:24866155
NetTepi: an integrated method for the prediction of T cell epitopes. PMID:24863339
Immunogenicity of recombinant human bocavirus-1,2 VP2 gene virus-like particles in mice. PMID:24843872
Hepatitis B splice-generated protein antibodies in Syrian chronic hepatitis B patients: incidence and significance. PMID:24829585
Can we predict mutant neoepitopes in human cancers for patient-specific vaccine therapy? PMID:24795140
Combined cytolytic effects of a vaccinia virus encoding a single chain trimer of MHC-I with a Tax-epitope and Tax-specific CTLs on HTLV-I-infected cells in a rat model. PMID:24791004
High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes. PMID:24755960
Effects of Peptide on NK cell-mediated MHC I recognition. PMID:24744756
Comparison of experimental fine-mapping to in silico prediction results of HIV-1 epitopes reveals ongoing need for mapping experiments. PMID:24724694
Clinical and immunological markers of dengue progression in a study cohort from a hyperendemic area in Malaysia. PMID:24647042
Ovine and murine T cell epitopes from the non-structural protein 1 (NS1) of bluetongue virus serotype 8 (BTV-8) are shared among viral serotypes. PMID:24621015
Rapid generation of a mouse model for Middle East respiratory syndrome. PMID:24599590
An effective and effecient peptide binding prediction approach for a broad set of HLA-DR molecules based on ordered weighted averaging of binding pocket profiles. PMID:24565049
Noncanonical expression of a murine cytomegalovirus early protein CD8 T-cell epitope as an immediate early epitope based on transcription from an upstream gene. PMID:24535000
Enhanced early innate and T cell-mediated responses in subjects immunized with Anthrax Vaccine Adsorbed Plus CPG 7909 (AV7909). PMID:24530403
T-cell responses to oncogenic merkel cell polyomavirus proteins distinguish patients with merkel cell carcinoma from healthy donors. PMID:24526738
DNA vaccines encoding altered peptide ligands for SSX2 enhance epitope-specific CD8+ T-cell immune responses. PMID:24492013
Improved pan-specific MHC class I peptide-binding predictions using a novel representation of the MHC-binding cleft environment. PMID:24447175
LAPTM4B-35 protein is a weak tumor-associated antigen candidate. PMID:24396432
Alphavirus-based vaccines encoding nonstructural proteins of hepatitis C virus induce robust and protective T-cell responses. PMID:24370701
Short peptide sequence identity between human viruses and HLA-B27-binding human 'self' peptides. PMID:24362932
Selection of conserved epitopes from hepatitis C virus for pan-populational stimulation of T-cell responses. PMID:24348677
Immunological characterization of a modified vaccinia virus Ankara vector expressing the human papillomavirus 16 E1 protein. PMID:24307238
Designing of interferon-gamma inducing MHC class-II binders. PMID:24304645
Identification of immunological biomarkers which may differentiate latent tuberculosis from exposure to environmental nontuberculous mycobacteria in children. PMID:24285818
Concerted in vitro trimming of viral HLA-B27-restricted ligands by human ERAP1 and ERAP2 aminopeptidases. PMID:24223975
Cancer genome sequencing and its implications for personalized cancer vaccines. PMID:24213133
Properties of MHC class I presented peptides that enhance immunogenicity. PMID:24204222
HLA class I alleles are associated with peptide-binding repertoires of different size, affinity, and immunogenicity. PMID:24190657
Sequence analysis of T-cell repertoires in health and disease. PMID:24172704
Development of a peptide-based vaccine targeting TMPRSS2:ERG fusion-positive prostate cancer. PMID:24149465
HPV16 E5 peptide vaccine in treatment of cervical cancer in vitro and in vivo. PMID:24142729
Prediction and characterization of helper T-cell epitopes from pneumococcal surface adhesin A. PMID:24138116
Thermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal. PMID:24101920
HLA ligandome tumor antigen discovery for personalized vaccine approach. PMID:24090147
Dipeptides promote folding and peptide binding of MHC class I molecules. PMID:24003162
Uroplakin peptide-specific autoimmunity initiates interstitial cystitis/painful bladder syndrome in mice. PMID:23977210
Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies. PMID:23970885
Advances in the study of HLA-restricted epitope vaccines. PMID:23955319
NetMHCstab - predicting stability of peptide-MHC-I complexes; impacts for cytotoxic T lymphocyte epitope discovery. PMID:23927693
Immunogenicity of HLA-DR1 Restricted Peptides Derived from Leishmania major gp63 Using FVB/N-DR1 Transgenic Mouse Model. PMID:23914241
HLA Class II tetramers reveal tissue-specific regulatory T cells that suppress T-cell responses in breast carcinoma patients. PMID:23894725
An analogue peptide from the Cancer/Testis antigen PASD1 induces CD8+ T cell responses against naturally processed peptide. PMID:23882161
Peptide-based vaccinology: experimental and computational approaches to target hypervariable viruses through the fine characterization of protective epitopes recognized by monoclonal antibodies and the identification of T-cell-activating peptides. PMID:23878584
Active vaccination with vaccinia virus A33 protects mice against lethal vaccinia and ectromelia viruses but not against cowpoxvirus; elucidation of the specific adaptive immune response. PMID:23842430
Location of the CD8 T cell epitope within the antigenic precursor determines immunogenicity and protection against the Toxoplasma gondii parasite. PMID:23818852
Integrating peptides' sequence and energy of contact residues information improves prediction of peptide and HLA-I binding with unknown alleles. PMID:23815611
Advances in T-cell epitope engineering. PMID:23761792
Scrutinizing MHC-I binding peptides and their limits of variation. PMID:23754940
Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE. PMID:23750208
Heterologous vaccination against human tuberculosis modulates antigen-specific CD4+ T-cell function. PMID:23737382
Presentation of an immunodominant immediate-early CD8+ T cell epitope resists human cytomegalovirus immunoevasion. PMID:23717207
A combination of epitope prediction and molecular docking allows for good identification of MHC class I restricted T-cell epitopes. PMID:23666426
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. PMID:23644516
A novel transport mechanism for MOMP in Chlamydophila pneumoniae and its putative role in immune-therapy. PMID:23637791
Prime/boost immunization with DNA and adenoviral vectors protects from hepatitis D virus (HDV) infection after simultaneous infection with HDV and woodchuck hepatitis virus. PMID:23637419
Short-term in-vitro expansion improves monitoring and allows affordable generation of virus-specific T-cells against several viruses for a broad clinical application. PMID:23630567
Diversity of natural self-derived ligands presented by different HLA class I molecules in transporter antigen processing-deficient cells. PMID:23555621
A broad profile of co-dominant epitopes shapes the peripheral Mycobacterium tuberculosis specific CD8+ T-cell immune response in South African patients with active tuberculosis. PMID:23555576
Molecular characterization of HTLV-1 gp46 glycoprotein from health carriers and HAM/TSP infected individuals. PMID:23510700
The human leukocyte antigen-presented ligandome of B lymphocytes. PMID:23481700
Predictor for the effect of amino acid composition on CD4+ T cell epitopes preprocessing. PMID:23481624
Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer: a clinical phase I/II study. PMID:23458999
Predicted peptides from non-structural proteins of porcine reproductive and respiratory syndrome virus are able to induce IFN-γ and IL-10. PMID:23435238
Natural HLA-B*2705 protein ligands with glutamine as anchor motif: implications for HLA-B27 association with spondyloarthropathy. PMID:23430249
PREDIVAC: CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity. PMID:23409948
Measurement of MHC/peptide interactions by gel filtration or monoclonal antibody capture. PMID:23392640
Prediction of MHC class I binding peptides by a query learning algorithm based on hidden markov models. PMID:23345768
Fowlpox-based survivin vaccination for malignant mesothelioma therapy. PMID:23335100
Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules. PMID:23334921
Immunogenicity of MHC Class I Peptides Derived from Leishmania mexicana Gp63 in HLA-A2.1 Transgenic (HHDII) and BALB/C Mouse Models. PMID:23323089
T-cell epitope vaccine design by immunoinformatics. PMID:23303307
Characterization of Ewing sarcoma associated cancer/testis antigens. PMID:23291981
Varicella zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans. PMID:23284056
Vaccination using peptides spanning the SYT-SSX tumor-specific translocation. PMID:23252384
An efficient T-cell epitope discovery strategy using in silico prediction and the iTopia assay platform. PMID:23243589
Identification and characterization of H-2d restricted CD4+ T cell epitopes on Lpp20 of Helicobacter pylori. PMID:23234363
Sequence-based in silico analysis of well studied hepatitis C virus epitopes and their variants in other genotypes (particularly genotype 5a) against South African human leukocyte antigen backgrounds. PMID:23227878
Identification of a novel p190-derived breakpoint Peptide suitable for Peptide vaccine therapeutic approach in ph+ acute lymphoblastic leukemia patients. PMID:23198152
Enzymatic discovery of a HER-2/neu epitope that generates cross-reactive T cells. PMID:23180824
The epitopes in wheat proteins for defining toxic units relevant to human health. PMID:23179564
EpicCapo: epitope prediction using combined information of amino acid pairwise contact potentials and HLA-peptide contact site information. PMID:23176036
A rationally engineered anti-HIV peptide fusion inhibitor with greatly reduced immunogenicity. PMID:23147734
MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response. PMID:23144892
Vaccines: from empirical development to rational design. PMID:23144616
A cell-based MHC stabilization assay for the detection of peptide binding to the canine classical class I molecule, DLA-88. PMID:23062801
Epitope-specificity of recombinant antibodies reveals promiscuous peptide-binding properties. PMID:23034898
A genetic and pathologic study of a DENV2 clinical isolate capable of inducing encephalitis and hematological disturbances in immunocompetent mice. PMID:23028722
Bioinformatics for cancer immunology and immunotherapy. PMID:22986455
HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives. PMID:22966084
Social discrimination by quantitative assessment of immunogenetic similarity. PMID:22951741
Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases? PMID:22951444
CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity. PMID:22943201
A viral, transporter associated with antigen processing (TAP)-independent, high affinity ligand with alternative interactions endogenously presented by the nonclassical human leukocyte antigen E class I molecule. PMID:22927436
Nuclear export signal and immunodominant CD8+ T cell epitope in influenza A virus matrix protein 1. PMID:22923812
Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging. PMID:22916012
Predicting HLA class I non-permissive amino acid residues substitutions. PMID:22905104
Constitutive and inflammatory immunopeptidome of pancreatic β-cells. PMID:22872234
High immunogenicity of the human leukocyte antigen peptidomes of melanoma tumor cells. PMID:22869377
Development of a novel in silico docking simulation model for the fine HIV-1 cytotoxic T lymphocyte epitope mapping. PMID:22848572
Driving forces of proteasome-catalyzed peptide splicing in yeast and humans. PMID:22822185
HLA-Cw*0102-restricted HIV-1 p24 epitope variants can modulate the binding of the inhibitory KIR2DL2 receptor and primary NK cell function. PMID:22807681
Prediction and identification of T cell epitopes in the H5N1 influenza virus nucleoprotein in chicken. PMID:22745738
DNA prime-adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model. PMID:22718818
Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins. PMID:22695180
Seq2Logo: a method for construction and visualization of amino acid binding motifs and sequence profiles including sequence weighting, pseudo counts and two-sided representation of amino acid enrichment and depletion. PMID:22638583
Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1(+) leukemias. PMID:22623625
Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity. PMID:22617051
ZnT8 is a major CD8+ T cell-recognized autoantigen in pediatric type 1 diabetes. PMID:22586580
HapMap SNP Scanner: an online program to mine SNPs responsible for cell phenotype. PMID:22568758
Trypanosoma cruzi adjuvants potentiate T cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine. PMID:22567144
Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using Peptide block entropy. PMID:22566858
Antigen processing by macroautophagy for MHC presentation. PMID:22566832
Comparing the similarity of different groups of bacteria to the human proteome. PMID:22558081
In vitro and in vivo identification of a novel cytotoxic T lymphocyte epitope from Rv3425 of Mycobacterium tuberculosis. PMID:22537173
Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen. PMID:22529286
PolysacDB: a database of microbial polysaccharide antigens and their antibodies. PMID:22509333
Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides. PMID:22484809
GPS-MBA: computational analysis of MHC class II epitopes in type 1 diabetes. PMID:22479466
Interaction pattern of Arg 62 in the A-pocket of differentially disease-associated HLA-B27 subtypes suggests distinct TCR binding modes. PMID:22403718
TEPITOPEpan: extending TEPITOPE for peptide binding prediction covering over 700 HLA-DR molecules. PMID:22383964
Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4+ and CD8+ T cells in melanoma patients. PMID:22371843
Autophagy in innate recognition of pathogens and adaptive immunity. PMID:22318809
Whole genomes of Chandipura virus isolates and comparative analysis with other rhabdoviruses. PMID:22272333
Discovery of T cell antigens by high-throughput screening of synthetic minigene libraries. PMID:22253836
The development of Chinese specific human cytomegalovirus polyepitope recombinant vaccine. PMID:22197248
Predictions versus high-throughput experiments in T-cell epitope discovery: competition or synergy? PMID:22149708
Steric recognition of T-cell receptor contact residues is required to map mutant epitopes by immunoinformatical programmes. PMID:22121944
Identification of three novel CTL epitopes within nucleocapsid protein of Hantaan virus. PMID:22111596
POPISK: T-cell reactivity prediction using support vector machines and string kernels. PMID:22085524
NNAlign: a web-based prediction method allowing non-expert end-user discovery of sequence motifs in quantitative peptide data. PMID:22073191
Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease. PMID:22072755
Multiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cells. PMID:22031944
Computational vaccinology: an important strategy to discover new potential S. mansoni vaccine candidates. PMID:22013383
[Prostate carcinoma: vaccination as a new option for treatment]. PMID:21989588
GM-CSF production allows the identification of immunoprevalent antigens recognized by human CD4+ T cells following smallpox vaccination. PMID:21931646
Mass spectrometry analysis and quantitation of peptides presented on the MHC II molecules of mouse spleen dendritic cells. PMID:21913724
In silico analysis of six known Leishmania major antigens and in vitro evaluation of specific epitopes eliciting HLA-A2 restricted CD8 T cell response. PMID:21909442
Vaccines targeting the cancer-testis antigen SSX-2 elicit HLA-A2 epitope-specific cytolytic T cells. PMID:21904219
Common minor histocompatibility antigen discovery based upon patient clinical outcomes and genomic data. PMID:21858034
High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations. PMID:21850230
Recognition of class I MHC by a rat Ly49 NK cell receptor is dependent on the identity of the P2 anchor amino acid of bound peptide. PMID:21841133
OETMAP: a new feature encoding scheme for MHC class I binding prediction. PMID:21805091
Dana-Farber repository for machine learning in immunology. PMID:21782820
Emerging vaccine informatics. PMID:21772787
Multidrug-resistance proteins are weak tumor associated antigens for colorectal carcinoma. PMID:21740599
Therapeutic cancer vaccines and translating vaccinomics science to the global health clinic: emerging applications toward proof of concept. PMID:21732821
Efficacy of HLA-DRB1∗03:01 and H2E transgenic mouse strains to correlate pathogenic thyroglobulin epitopes for autoimmune thyroiditis. PMID:21683551
PeptX: using genetic algorithms to optimize peptides for MHC binding. PMID:21679477
Whole-genome immunoinformatic analysis of F. tularensis: predicted CTL epitopes clustered in hotspots are prone to elicit a T-cell response. PMID:21625462
Identification of CD8+ cytotoxic T lymphocyte epitopes from porcine reproductive and respiratory syndrome virus matrix protein in BALB/c mice. PMID:21619712
Rhesus macaque KIR bind human MHC class I with broad specificity and recognize HLA-C more effectively than HLA-A and HLA-B. PMID:21614583
Identification and characterization of human leukocyte antigen class I ligands in renal cell carcinoma cells. PMID:21595034
CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope. PMID:21589903
Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1*0401-positive humanized mice and rheumatoid arthritis patients. PMID:21567378
Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection. PMID:21525339
Tapasin discriminates peptide-human leukocyte antigen-A*02:01 complexes formed with natural ligands. PMID:21518758
Pivotal role of antibody and subsidiary contribution of CD8+ T cells to recovery from infection in a murine model of Japanese encephalitis. PMID:21450826
Cytolytic T lymphocytes from HLA-B8+ donors frequently recognize the Hodgkin's lymphoma associated latent membrane protein 2 of Epstein Barr virus. PMID:21429247
Expansion of interferon-gamma-producing multifunctional CD4+ T-cells and dysfunctional CD8+ T-cells by glypican-3 peptide library in hepatocellular carcinoma patients. PMID:21419713
Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis. PMID:21413052
Specific recognition and inhibition of Ewing tumour growth by antigen-specific allo-restricted cytotoxic T cells. PMID:21407224
Insights into MHC class I antigen processing gained from large-scale analysis of class I ligands. PMID:21387142
CD8+ T cells specific for the androgen receptor are common in patients with prostate cancer and are able to lyse prostate tumor cells. PMID:21350948
Advances of bioinformatics tools applied in virus epitopes prediction. PMID:21331885
Optimal epitope composition after antigen screening using a live bacterial delivery vector: application to TRP-2. PMID:21327126
Reverse genetics modification of cytomegalovirus antigenicity and immunogenicity by CD8 T-cell epitope deletion and insertion. PMID:21253509
Effect of immune pressure on hepatitis C virus evolution: insights from a single-source outbreak. PMID:21246583
Structural properties of MHC class II ligands, implications for the prediction of MHC class II epitopes. PMID:21209859
Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires. PMID:21209280
Mycobacterium tuberculosis directs immunofocusing of CD8+ T cell responses despite vaccination. PMID:21178003
Screening of human tumor antigens for CD4 T cell epitopes by combination of HLA-transgenic mice, recombinant adenovirus and antigen peptide libraries. PMID:21152437
Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability. PMID:21130497
Peptide binding predictions for HLA DR, DP and DQ molecules. PMID:21092157
NetMHCIIpan-2.0 - Improved pan-specific HLA-DR predictions using a novel concurrent alignment and weight optimization training procedure. PMID:21073747
State of the art and challenges in sequence based T-cell epitope prediction. PMID:21067545
Computer aided selection of candidate vaccine antigens. PMID:21067543
Prediction of epitopes using neural network based methods. PMID:21047511
Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors. PMID:20981424
The SSX family of cancer-testis antigens as target proteins for tumor therapy. PMID:20981248
Soluble plasma HLA peptidome as a potential source for cancer biomarkers. PMID:20974924
The identification of HLA class II-restricted T cell epitopes to vaccinia virus membrane proteins. PMID:20961593
Molecular modeling of class I and II alleles of the major histocompatibility complex in Salmo salar. PMID:20936494
The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family. PMID:20934997
MHC-I prediction using a combination of T cell epitopes and MHC-I binding peptides. PMID:20920507
Dendritic cells reveal a broad range of MHC class I epitopes for HIV-1 in persons with suppressed viral load on antiretroviral therapy. PMID:20886040
MultiRTA: a simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes. PMID:20868497
MHC presentation via autophagy and how viruses escape from it. PMID:20857294
Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein. PMID:20844028
Immunoinformatics: an integrated scenario. PMID:20722763
CD8+ T cell response in HLA-A*0201 transgenic mice is elicited by epitopes from SARS-CoV S protein. PMID:20709007
AIDS-protective HLA-B*27/B*57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz. PMID:20696916
Vaxign: the first web-based vaccine design program for reverse vaccinology and applications for vaccine development. PMID:20671958
Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks. PMID:20658465
Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. PMID:20639478
Contribution of CD8 T lymphocytes to the immuno-pathogenesis of multiple sclerosis and its animal models. PMID:20637863
Mutation-specific control of BCR-ABL T315I positive leukemia with a recombinant yeast-based therapeutic vaccine in a murine model. PMID:20619375
High throughput T epitope mapping and vaccine development. PMID:20617148
Structure and function of major histocompatibility complex class I antigens. PMID:20613521
T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice. PMID:20610717
Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1. PMID:20592285
CD8+ T cell recognition of polymorphic wild-type sequence p53(65-73) peptides in squamous cell carcinoma of the head and neck. PMID:20577877
T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts. PMID:20554960
Major histocompatibility complex class I binding predictions as a tool in epitope discovery. PMID:20518827
MHC I stabilizing potential of computer-designed octapeptides. PMID:20508831
Induction of Specific CD8 T Cells against Intracellular Bacteria by CD8 T-Cell-Oriented Immunization Approaches. PMID:20508818
MetaMHC: a meta approach to predict peptides binding to MHC molecules. PMID:20483919
Graft-versus-leukemia antigen CML66 elicits coordinated B-cell and T-cell immunity after donor lymphocyte infusion. PMID:20460482
Rapid T cell-based identification of human tumor tissue antigens by automated two-dimensional protein fractionation. PMID:20458140
Genetic immunization with CDR3-based fusion vaccine confers protection and long-term tumor-free survival in a mouse model of lymphoma. PMID:20445751
Antitumor cytotoxic T-cell response induced by a survivin peptide mimic. PMID:20422411
MHC class II epitope predictive algorithms. PMID:20408898
Optimization algorithms for functional deimmunization of therapeutic proteins. PMID:20380721
NetCTLpan: pan-specific MHC class I pathway epitope predictions. PMID:20379710
Design and utilization of epitope-based databases and predictive tools. PMID:20213141
Leukemia-associated minor histocompatibility antigen discovery using T-cell clones isolated by in vitro stimulation of naive CD8+ T cells. PMID:20203263
MHC-based detection of antigen-specific CD8+ T cell responses. PMID:20177676
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. PMID:20173754
Predicting MHC class I epitopes in large datasets. PMID:20163709
HLA-A2-restricted T-cell epitopes specific for prostatic acid phosphatase. PMID:20140431
Genetic linkage of autologous T cell epitopes in a chimeric recombinant construct improves anti-parasite and anti-disease protective effect of a malaria vaccine candidate. PMID:20097151
Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model. PMID:20089173
Multiple, non-conserved, internal viral ligands naturally presented by HLA-B27 in human respiratory syncytial virus-infected cells. PMID:20081153
Prediction of functional class of proteins and peptides irrespective of sequence homology by support vector machines. PMID:20066123
Nucleophosmin is recognized by a cytotoxic T cell line derived from a rectal carcinoma patient. PMID:20027629
Proteasomes in immune cells: more than peptide producers? PMID:20010787
Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV. PMID:19958537
Novel immunogenic HLA-A*0201-restricted epidermal growth factor receptor-specific T-cell epitope in head and neck cancer patients. PMID:19952953
HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C. PMID:19935663
The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response. PMID:19933869
HLA-DR: molecular insights and vaccine design. PMID:19860674
Systematic characterisation of cellular localisation and expression profiles of proteins containing MHC ligands. PMID:19826487
Discovery of naturally processed and HLA-presented class I peptides from vaccinia virus infection using mass spectrometry for vaccine development. PMID:19822231
AntigenDB: an immunoinformatics database of pathogen antigens. PMID:19820110
Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma. PMID:19809157
Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation. PMID:19805168
NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction. PMID:19765293
Prediction of MHC class I binding peptides using probability distribution functions. PMID:19759816
Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a. PMID:19748524
Identification of HLA-A*2402-restricted HCMV immediate early-1 (IE-1) epitopes as targets for CD8+ HCMV-specific cytotoxic T lymphocytes. PMID:19698161
The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides. PMID:19667070
Development, characterization, and immunotherapeutic use of peptide mimics of the Thomsen-Friedenreich carbohydrate antigen. PMID:19649208
Adeno-associated virus serotype 2 induces cell-mediated immune responses directed against multiple epitopes of the capsid protein VP1. PMID:19641045
Virological and epitope evolution of HCV infection from acute hepatitis C to subsequent episodes of HCV-related acute liver cell necrosis. PMID:19636498
A HCMV pp65 polypeptide promotes the expansion of CD4+ and CD8+ T cells across a wide range of HLA specificities. PMID:19604317
Functional unresponsiveness and replicative senescence of myeloid leukemia antigen-specific CD8+ T cells after allogeneic stem cell transplantation. PMID:19602548
Modeling the repertoire of true tumor-specific MHC I epitopes in a human tumor. PMID:19593447
Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis. PMID:19590042
Discovery of novel targets for multi-epitope vaccines: screening of HIV-1 genomes using association rule mining. PMID:19580659
FRED--a framework for T-cell epitope detection. PMID:19578173
Gene expression profiling and real-time PCR analyses identify novel potential cancer-testis antigens in multiple myeloma. PMID:19542363
Genome-wide screening of human T-cell epitopes in influenza A virus reveals a broad spectrum of CD4(+) T-cell responses to internal proteins, hemagglutinins, and neuraminidases. PMID:19524006
Autophagy as an emerging dimension to adaptive and innate immunity. PMID:19502083
Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity. PMID:19494300
Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice. PMID:19490987
Viruses selectively mutate their CD8+ T-cell epitopes--a large-scale immunomic analysis. PMID:19478014
Analysis of Mycobacterium tuberculosis-specific CD8 T-cells in patients with active tuberculosis and in individuals with latent infection. PMID:19436760
OptiTope--a web server for the selection of an optimal set of peptides for epitope-based vaccines. PMID:19420066
Identification of varicella-zoster virus-specific CD8 T cells in patients after T-cell-depleted allogeneic stem cell transplantation. PMID:19386715
Immunoinformatics: current trends and future directions. PMID:19379830
MHCBN 4.0: A database of MHC/TAP binding peptides and T-cell epitopes. PMID:19379493
T-cell epitope prediction: rescaling can mask biological variation between MHC molecules. PMID:19300484
Human self-protein CD8+ T-cell epitopes are both positively and negatively selected. PMID:19291702
Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection. PMID:19264627
Is the risk of multiple sclerosis related to the 'biography' of the immune system? PMID:19252771
Prediction of MHC binding peptide using Gibbs motif sampler, weight matrix and artificial neural network. PMID:19238237
Identification of naturally processed ligands in the C57BL/6 mouse using large-scale mass spectrometric peptide sequencing and bioinformatics prediction. PMID:19224205
Adoptive immunotherapy of disseminated leukemia with TCR-transduced, CD8+ T cells expressing a known endogenous TCR. PMID:19209146
A mathematical framework for the selection of an optimal set of peptides for epitope-based vaccines. PMID:19112482
Evaluation of MHC-II peptide binding prediction servers: applications for vaccine research. PMID:19091022
NetMHCpan, a method for MHC class I binding prediction beyond humans. PMID:19002680
Pan-specific MHC class I predictors: a benchmark of HLA class I pan-specific prediction methods. PMID:18996943
Vaccinia virus-specific CD8(+) T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans. PMID:18955096
Flanking p10 contribution and sequence bias in matrix based epitope prediction: revisiting the assumption of independent binding pockets. PMID:18925947
Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes. PMID:18922097
A new model defines the minimal set of polymorphism in HLA-DQ and -DR that determines susceptibility and resistance to autoimmune diabetes. PMID:18854049
Activation and detection of HTLV-I Tax-specific CTLs by epitope expressing single-chain trimers of MHC class I in a rat model. PMID:18840303
Evidence for positive selection in putative virulence factors within the Paracoccidioides brasiliensis species complex. PMID:18820744
Improving peptide-MHC class I binding prediction for unbalanced datasets. PMID:18803836
MHC motif viewer. PMID:18766337
iSPOT: a web tool for the analysis and recognition of protein domain specificity. PMID:18629248
Quantitative predictions of peptide binding to any HLA-DR molecule of known sequence: NetMHCIIpan. PMID:18604266
Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum. PMID:18587399
Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. PMID:18549802
Autophagy and viral neurovirulence. PMID:18503639
Peptide epitope identification for tumor-reactive CD4 T cells. PMID:18499419
A novel H2A-E+ transgenic model susceptible to human but not mouse thyroglobulin-induced autoimmune thyroiditis: identification of mouse pathogenic epitopes. PMID:18489063
NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11. PMID:18463140
Lack of immune responses against multiple sclerosis-associated retrovirus/human endogenous retrovirus W in patients with multiple sclerosis. PMID:18444086
EpiToolKit--a web server for computational immunomics. PMID:18440979
Therapeutic effect of a T helper cell supported CTL response induced by a survivin peptide vaccine against murine cerebral glioma. PMID:18438666
A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PMID:18389056
Evaluation of MHC class I peptide binding prediction servers: applications for vaccine research. PMID:18366636
Identification of novel IGRP epitopes targeted in type 1 diabetes patients. PMID:18358785
Amino acid similarity accounts for T cell cross-reactivity and for "holes" in the T cell repertoire. PMID:18350167
Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen proteomes. PMID:18315850
Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery. PMID:18311511
Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7. PMID:18308940
DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells. PMID:18299450
The MHC class I peptide repertoire is molded by the transcriptome. PMID:18299400
Autophagy and antiviral immunity. PMID:18262399
Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses. PMID:18246204
Coping with loss of perfection in the MHC class I peptide repertoire. PMID:18243675
Response to M. tuberculosis selected RD1 peptides in Ugandan HIV-infected patients with smear positive pulmonary tuberculosis: a pilot study. PMID:18226199
Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries. PMID:18221540
Identification of an HLA-A*0201-restricted T-cell epitope on the MPT51 protein, a major secreted protein derived from Mycobacterium tuberculosis, by MPT51 overlapping peptide screening. PMID:18212086
HLA class I supertypes: a revised and updated classification. PMID:18211710
The contributions of mass spectrometry to understanding of immune recognition by T lymphocytes. PMID:18167512
Diversity and evolution of the rhoph1/clag multigene family of Plasmodium falciparum. PMID:18155305
Characterizing the Mycobacterium tuberculosis Rv2707 protein and determining its sequences which specifically bind to two human cell lines. PMID:18096644
A probabilistic meta-predictor for the MHC class II binding peptides. PMID:18092156
Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity? PMID:18082388
Tat protein vaccination of cynomolgus macaques influences SHIV-89.6P cy243 epitope variability. PMID:18049888
Modeling the adaptive immune system: predictions and simulations. PMID:18045832
Robust quantitative modeling of peptide binding affinities for MHC molecules using physical-chemical descriptors. PMID:18045233
Induction of human immunodeficiency virus (HIV-1) envelope specific cell-mediated immunity by a non-homologous synthetic peptide. PMID:18043730
Predicting peptides binding to MHC class II molecules using multi-objective evolutionary algorithms. PMID:18031584
CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation. PMID:18000532
T cell responses to human endogenous retroviruses in HIV-1 infection. PMID:17997601
Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction. PMID:17973982
Human CD4+ T cell epitopes from vaccinia virus induced by vaccination or infection. PMID:17937498
NetMHCpan, a method for quantitative predictions of peptide binding to any HLA-A and -B locus protein of known sequence. PMID:17726526
In silico characterization of immunogenic epitopes presented by HLA-Cw*0401. PMID:17705876
Extensive HLA class I allele promiscuity among viral CTL epitopes. PMID:17705138
Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection. PMID:17692881
PepBank--a database of peptides based on sequence text mining and public peptide data sources. PMID:17678535
Innate and adaptive immunity through autophagy. PMID:17663981
Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1. PMID:17616974
Phase-dependent immune evasion of herpesviruses. PMID:17609281
Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method. PMID:17608956
Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. PMID:17604453
Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin. PMID:17507491
Identification of synthetic vaccine candidates against SARS CoV infection. PMID:17506989
Epitope mapping of HSV-1 glycoprotein K (gK) reveals a T cell epitope located within the signal domain of gK. PMID:17499382
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. PMID:17496894
Long-term T cell memory to human leucocyte antigen-A2 supertype epitopes in humans vaccinated against smallpox. PMID:17488297
Integrating epitope data into the emerging web of biomedical knowledge resources. PMID:17479127
MODPROPEP: a program for knowledge-based modeling of protein-peptide complexes. PMID:17478500
Cellular and humoral immune responses to alphavirus replicon vaccines expressing cytomegalovirus pp65, IE1, and gB proteins. PMID:17442845
A hybrid approach for predicting promiscuous MHC class I restricted T cell epitopes. PMID:17426378
IDR knowledge base for primary immunodeficiencies. PMID:17394641
Identification and characterization of dominant helper T-cell epitopes in the nucleocapsid protein of severe acute respiratory syndrome coronavirus. PMID:17392374
Strength in numbers: achieving greater accuracy in MHC-I binding prediction by combining the results from multiple prediction tools. PMID:17381846
Identification of SOX2 as a novel glioma-associated antigen and potential target for T cell-based immunotherapy. PMID:17375044
Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities. PMID:17371945
Hepatitis B virus splice-generated protein induces T-cell responses in HLA-transgenic mice and hepatitis B virus-infected patients. PMID:17360751
Enhanced detection of human immunodeficiency virus type 1 (HIV-1) Nef-specific T cells recognizing multiple variants in early HIV-1 infection. PMID:17329342
Telomerase immunity from bench to bedside: round one. PMID:17324292
Peptide vaccine given with a Toll-like receptor agonist is effective for the treatment and prevention of spontaneous breast tumors. PMID:17283170
Prediction of cellular immune responses against CFTR in patients with cystic fibrosis after gene therapy. PMID:17218617
Dual selection pressure by drugs and HLA class I-restricted immune responses on human immunodeficiency virus type 1 protease. PMID:17202219
Natural selection for rash-forming genotypes of the varicella-zoster vaccine virus detected within immunized human hosts. PMID:17182747
Tissue-specific regulation of CD8+ T-lymphocyte immunodominance in respiratory syncytial virus infection. PMID:17182672
Processing sites are different in the generation of HLA-A2.1-restricted, T cell reactive tumor antigen epitopes and viral epitopes. PMID:17166407
Sampling of major histocompatibility complex class I-associated peptidome suggests relatively looser global association of HLA-B*5101 with peptides. PMID:17145369
A modular concept of HLA for comprehensive peptide binding prediction. PMID:17119951
The separate and combined effects of MHC genotype, parasite clone, and host gender on the course of malaria in mice. PMID:17118203
Predicting Class II MHC-Peptide binding: a kernel based approach using similarity scores. PMID:17105666
Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide. PMID:17067310
SVRMHC prediction server for MHC-binding peptides. PMID:17059589
Dynamics of immature subsets of dendritic cells during antiviral therapy in HLA-A24-positive chronic hepatitis C patients. PMID:16988764
Immunoinformatics comes of age. PMID:16846250
SVMHC: a server for prediction of MHC-binding peptides. PMID:16844990
Curation of complex, context-dependent immunological data. PMID:16836764
MHC-BPS: MHC-binder prediction server for identifying peptides of flexible lengths from sequence-derived physicochemical properties. PMID:16832638
Insights into amprenavir resistance in E35D HIV-1 protease mutation from molecular dynamics and binding free-energy calculations. PMID:16794810
A community resource benchmarking predictions of peptide binding to MHC-I molecules. PMID:16789818
Human antibody responses of patients living in endemic areas for schistosomiasis to the tegumental protein Sm29 identified through genomic studies. PMID:16734606
A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens. PMID:16603084
CED: a conformational epitope database. PMID:16603068
Quantitative prediction of mouse class I MHC peptide binding affinity using support vector machine regression (SVR) models. PMID:16579851
EpiJen: a server for multistep T cell epitope prediction. PMID:16533401
Autophagy in innate and adaptive immunity against intracellular pathogens. PMID:16501849
Cytotoxic T-lymphocyte epitope vaccination protects against human metapneumovirus infection and disease in mice. PMID:16439559
Prediction of MHC class II binding peptides based on an iterative learning model. PMID:16351712
SNEP: SNP-derived epitope prediction program for minor H antigens. PMID:16341860
AntiJen: a quantitative immunology database integrating functional, thermodynamic, kinetic, biophysical, and cellular data. PMID:16305757
An ontology for immune epitopes: application to the design of a broad scope database of immune reactivities. PMID:16305755
Diversity in the acute CD8 T cell response to vaccinia virus in humans. PMID:16301664
Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infection. PMID:16299302
Neonatal and maternal immunological responses to conserved epitopes within the DBL-gamma3 chondroitin sulfate A-binding domain of Plasmodium falciparum erythrocyte membrane protein 1. PMID:16299291
CD4+-T-cell responses generated during murine Salmonella enterica serovar Typhimurium infection are directed towards multiple epitopes within the natural antigen FliC. PMID:16239517
HLA Class II molecules on haplotypes associated with type 1 diabetes exhibit similar patterns of binding affinities for coxsackievirus P2C peptides. PMID:16236123
Lassa fever virus peptides predicted by computational analysis induce epitope-specific cytotoxic-T-lymphocyte responses in HLA-A2.1 transgenic mice. PMID:16210487
Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains. PMID:16177312
Broad cross-clade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): importance of HLA anchor residue conservation. PMID:16103177
The sentinel within: exploiting the immune system for cancer biomarkers. PMID:16083262
HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load. PMID:16051815
Design of enhanced agonists through the use of a new virtual screening method: application to peptides that bind class I major histocompatibility complex (MHC) molecules. PMID:16046628
Integrated modeling of the major events in the MHC class I antigen processing pathway. PMID:15987883
PREDBALB/c: a system for the prediction of peptide binding to H2d molecules, a haplotype of the BALB/c mouse. PMID:15980450
MULTIPRED: a computational system for prediction of promiscuous HLA binding peptides. PMID:15980449
Recognition of six-transmembrane epithelial antigen of the prostate-expressing tumor cells by peptide antigen-induced cytotoxic T lymphocytes. PMID:15958640
Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method. PMID:15927070
Bcipep: a database of B-cell epitopes. PMID:15921533
CD4+ T cells play a dominant role in protection against New World leishmaniasis induced by vaccination with the P-4 amastigote antigen. PMID:15908422
Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications. PMID:15868141
Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid. PMID:15841217
Lack of effective T-lymphocyte response to the PAX3/FKHR translocation area in alveolar rhabdomyosarcoma. PMID:15838707
H-2 Kd-restricted hepatitis B virus-derived epitope whose specific CD8+ T lymphocytes can produce gamma interferon without cytotoxicity. PMID:15827171
Identification of murine CD8 T cell epitopes in codon-optimized SARS-associated coronavirus spike protein. PMID:15823604
Molecular epidemiology of hepatitis C virus genotype 4 isolates in Egypt and analysis of the variability of envelope proteins E1 and E2 in patients with chronic hepatitis. PMID:15815016
Identification of a new HLA-A*0201-restricted CD8+ T cell epitope from hepatocellular carcinoma-associated antigen HCA587. PMID:15807856
Novel biochemistry: post-translational protein splicing and other lessons from the school of antigen processing. PMID:15759099
Mate choice decisions of stickleback females predictably modified by MHC peptide ligands. PMID:15755811
Characterization of the peptide-binding specificity of Mamu-A*11 results in the identification of SIV-derived epitopes and interspecies cross-reactivity. PMID:15747117
The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage. PMID:15744535
CD8+ immunodominance among Epstein-Barr virus lytic cycle antigens directly reflects the efficiency of antigen presentation in lytically infected cells. PMID:15684323
NY-ESO-1 is highly expressed in poor-prognosis multiple myeloma and induces spontaneous humoral and cellular immune responses. PMID:15671442
Prediction of HLA-A2-restricted CTL epitope specific to HCC by SYFPEITHI combined with polynomial method. PMID:15633217
Epitope definition by proteomic similarity analysis: identification of the linear determinant of the anti-Dsg3 MAb 5H10. PMID:15588331
Identification of a naturally processed cytotoxic CD8 T-cell epitope of coxsackievirus B4, presented by HLA-A2.1 and located in the PEVKEK region of the P2C nonstructural protein. PMID:15564450
Enhancement to the RANKPEP resource for the prediction of peptide binding to MHC molecules using profiles. PMID:15349703
A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition. PMID:15331779
Discriminating self from nonself with short peptides from large proteomes. PMID:15322777
Modeling the structure of bound peptide ligands to major histocompatibility complex. PMID:15322290
Characterization of the 3a protein of SARS-associated coronavirus in infected vero E6 cells and SARS patients. PMID:15312778
Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. PMID:15289501
Mapping sites of positive selection and amino acid diversification in the HIV genome: an alternative approach to vaccine design? PMID:15280222
Identification of murine H2-Dd- and H2-Ab-restricted T-cell epitopes on a novel protective antigen, MPT51, of Mycobacterium tuberculosis. PMID:15213124
A novel predictive technique for the MHC class II peptide-binding interaction. PMID:15208743
Autologous lymphoma vaccines induce human T cell responses against multiple, unique epitopes. PMID:15146248
T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS. PMID:15140958
Autoreactive responses to an environmental factor. 2. Phthalate-induced anti-DNA specificity is downregulated by autoreactive cytotoxic T cells. PMID:15096189
An immunodominant SSX-2-derived epitope recognized by CD4+ T cells in association with HLA-DR. PMID:15085202
Identification of cryptic MHC I-restricted epitopes encoded by HIV-1 alternative reading frames. PMID:15078897
Sequence evolution of putative cytotoxic T cell epitopes in NS3 region of hepatitis C virus. PMID:15040030
HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase. PMID:15039371
Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein. PMID:14997204
Definition of supertypes for HLA molecules using clustering of specificity matrices. PMID:14963618
Induction of CD4+ Th1 lymphocytes that recognize known and novel class II MHC restricted epitopes from the melanoma antigen gp100 by stimulation with recombinant protein. PMID:14770079
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. PMID:14755342
Heterozygote advantage fails to explain the high degree of polymorphism of the MHC. PMID:14722686
Proteomics in Vaccinology and Immunobiology: An Informatics Perspective of the Immunone. PMID:14688414
Identification of B- and T-cell epitopes within the fibronectin-binding domain of the SfbI protein of Streptococcus pyogenes. PMID:14638816
Identification of a colorectal tumor-associated antigen (COA-1) recognized by CD4(+) T lymphocytes. PMID:14583468
Cytotoxic T-cell precursor frequencies to HER-2 (369-377) in patients with HER-2/neu-positive epithelial tumours. PMID:12966425
Bioinformatic analysis of functional differences between the immunoproteasome and the constitutive proteasome. PMID:12955356
Cell mediated immune responses against human prion protein. PMID:12930355
Identification of early secretory antigen target-6 epitopes for the immunodiagnosis of active tuberculosis. PMID:12865946
MHCPred: A server for quantitative prediction of peptide-MHC binding. PMID:12824380
Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. PMID:12815107
Respiratory syncytial virus nucleoprotein-specific cytotoxic T-cell epitopes in a South African population of diverse HLA types are conserved in circulating field strains. PMID:12805430
Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens. PMID:12771180
Large-scale analysis of HLA peptides presented by HLA-Cw4. PMID:12750860
A human minor histocompatibility antigen resulting from differential expression due to a gene deletion. PMID:12743171
Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide. PMID:12727928
Reliable prediction of T-cell epitopes using neural networks with novel sequence representations. PMID:12717023
Ex vivo profiling of CD8+-T-cell responses to human cytomegalovirus reveals broad and multispecific reactivities in healthy virus carriers. PMID:12692225
Class I molecules with similar peptide-binding specificities are the result of both common ancestry and convergent evolution. PMID:12671733
Identification of a novel human leucocyte antigen-A*01-restricted cytotoxic T-lymphocyte epitope in the respiratory syncytial virus fusion protein. PMID:12667209
Human papillomavirus type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6 mice. PMID:12663770
Use of transgenic HLA A*0201/Kb and HHD II mice to evaluate frequency of cytomegalovirus IE1-derived peptide usage in eliciting human CD8 cytokine response. PMID:12634406
Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines. PMID:12518065
Getting peptide vaccines to work: just a matter of quality control? PMID:12488425
Mosaic organization and heterogeneity in frequency of allelic recombination of the Plasmodium vivax merozoite surface protein-1 locus. PMID:12466500
Recovery of known T-cell epitopes by computational scanning of a viral genome. PMID:12400854
Prediction of MHC class I binding peptides, using SVMHC. PMID:12225620
Glycoprotein B from strain 17 of herpes simplex virus type I contains an invariant chain homologous sequence that binds to MHC class II molecules. PMID:12225371
Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus. PMID:12189248
Identification of Chlamydia pneumoniae-derived mouse CD8 epitopes. PMID:12065471
Cellular responses to Plasmodium falciparum erythrocyte membrane protein-1: use of relatively conserved synthetic peptide pools to determine CD4 T cell responses in malaria-exposed individuals in Benin, West Africa. PMID:12057026
Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. PMID:12021343
FIMM, a database of functional molecular immunology: update 2002. PMID:11752300
Rapid determination of HLA B*07 ligands from the West Nile virus NY99 genome. PMID:11585536
Identification of the immunodominant H-2K(k)-restricted cytotoxic T-cell epitope in the Borna disease virus nucleoprotein. PMID:11507203
The role of peptides in T cell alloreactivity is determined by self-major histocompatibility complex molecules. PMID:10704462
Target structures of the CD8(+)-T-cell response to human cytomegalovirus: the 72-kilodalton major immediate-early protein revisited. PMID:10482568

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major histocompatibility complex
metasource: Fairsharing.org
version: FAIRsharing.org: SYFPEITHI; Database of MHC Ligands and Peptide Motifs; DOI: https://doi.org/10.25504/FAIRsharing.k6vsdr; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:08 p.m.

peptide
metasource: Fairsharing.org
version: FAIRsharing.org: SYFPEITHI; Database of MHC Ligands and Peptide Motifs; DOI: https://doi.org/10.25504/FAIRsharing.k6vsdr; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:08 p.m.

protein
metasource: Fairsharing.org
version: FAIRsharing.org: SYFPEITHI; Database of MHC Ligands and Peptide Motifs; DOI: https://doi.org/10.25504/FAIRsharing.k6vsdr; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:08 p.m.

small molecule
metasource: Fairsharing.org
version: FAIRsharing.org: SYFPEITHI; Database of MHC Ligands and Peptide Motifs; DOI: https://doi.org/10.25504/FAIRsharing.k6vsdr; Last edited: Jan. 8, 2019, 1:16 p.m.; Last accessed: Jan 03 2022 7:08 p.m.

small molecules
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:35.495967

database management
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:35.495967

proteins
metasource: bio.tools
version: extracted_at: 2022-11-04T11:26:35.495967

major histocompatibility complex peptide protein small molecule small molecule data management proteins

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MHC Restriction Ontology

SysteMHC Atlas

IPD-MHC - Major Histocompatibility Complex Database

MaHCO

Antimicrobial Peptide Database

Propedia

MHCBN

ACEpepDB: Peptide Database

Minimum Information About a Peptide Array Experiment

PROFEAT

Dragon Antimicrobial Peptide Database

IEDB-3D

Immune Epitope Database

PepX

Het-PDB Navi

FireDB

PRoteomics IDEntifications database

SKEMPI

IPD-IMGT/HLA - Human Leukocyte Antigen Sequence Database

SuperScent