Target Central Resource Database
Names
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Target Central Resource Database
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
TCRD
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Names
More detailed information about this field from each metasource.
Target Central Resource Database
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
TCRD
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Names
More detailed information about this field from each metasource.
Target Central Resource Database
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
TCRD
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
TCRD is the central resource behind the Illuminating the Druggable Genome Knowledge Management Center (IDG-KMC). TCRD contains information about human targets, with special emphasis on four families of targets that are central to the NIH IDG initiative: GPCRs, kinases, ion channels and nuclear receptors. Olfactory GPCRs (oGPCRs) are treated as a separate family. A key aim of the KMC is to classify the development/druggability level of targets. The official public portal for TCRD is Pharos (pharos.nih.gov). Based on modern web design principles the Pharos interface provides facile access to all data types collected by the KMC. Given the complexity of the data surrounding any target, efficient and intuitive visualization has been a high priority, to enable users to quickly navigate & summarize search results and rapidly identify patterns. A critical feature of the interface is the ability to perform flexible search and subsequent drill down of search results. Underlying the interface is a RESTful API that provides programmatic access to all KMC data, allowing for easy consumption in user applications.
Description
More detailed information about this field from each metasource.
TCRD is the central resource behind the Illuminating the Druggable Genome Knowledge Management Center (IDG-KMC). TCRD contains information about human targets, with special emphasis on four families of targets that are central to the NIH IDG initiative: GPCRs, kinases, ion channels and nuclear receptors. Olfactory GPCRs (oGPCRs) are treated as a separate family. A key aim of the KMC is to classify the development/druggability level of targets. The official public portal for TCRD is Pharos (pharos.nih.gov). Based on modern web design principles the Pharos interface provides facile access to all data types collected by the KMC. Given the complexity of the data surrounding any target, efficient and intuitive visualization has been a high priority, to enable users to quickly navigate & summarize search results and rapidly identify patterns. A critical feature of the interface is the ability to perform flexible search and subsequent drill down of search results. Underlying the interface is a RESTful API that provides programmatic access to all KMC data, allowing for easy consumption in user applications.
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Webpage:
http://juniper.health.unm.edu/tcrd/Webpage
More detailed information about this field from each metasource.
http://juniper.health.unm.edu/tcrd/
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Licence:
Name: Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)Licence name
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Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Licence URL
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https://creativecommons.org/licenses/by-sa/4.0/
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Publications:
Publications
More detailed information about this field from each metasource.
Pharos: Collating protein information to shed light on the druggable genome
PMID: 27903890
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Publications
More detailed information about this field from each metasource.
Pharos: Collating protein information to shed light on the druggable genome
PMID: 27903890
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
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Pharos: Collating protein information to shed light on the druggable genome
PubMed citations: 102.
102 articles citing: Pharos: Collating protein information to shed light on the druggable genome
Repurposing Drugs via Network Analysis: Opportunities for Psychiatric Disorders. PMID:35890359
A Novel Based-Network Strategy to Identify Phytochemicals from Radix Salviae Miltiorrhizae (Danshen) for Treating Alzheimer's Disease. PMID:35889336
Using BERT to identify drug-target interactions from whole PubMed. PMID:35729494
Bioinformatic Analysis of the Perilymph Proteome to Generate a Human Protein Atlas. PMID:35573665
Gene-SCOUT: identifying genes with similar continuous trait fingerprints from phenome-wide association analyses. PMID:35474393
Application of Transcriptomics for Predicting Protein Interaction Networks, Drug Targets and Drug Candidates. PMID:35356062
Systematic illumination of druggable genes in cancer genomes. PMID:35196490
Machine learning prediction and tau-based screening identifies potential Alzheimer's disease genes relevant to immunity. PMID:35149761
A functional genomic approach to actionable gene fusions for precision oncology. PMID:35138907
Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis. PMID:35115556
Proteome-scale mapping of binding sites in the unstructured regions of the human proteome. PMID:35044719
Worldwide Protein Data Bank (wwPDB): A virtual treasure for research in biotechnology. PMID:34908533
RCSB Protein Data Bank resources for structure-facilitated design of mRNA vaccines for existing and emerging viral pathogens. PMID:34739839
Knowledge-based approaches to drug discovery for rare diseases. PMID:34718207
Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities. PMID:34705221
Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species. PMID:34570764
Single-Cell RNA-Seq of Cisplatin-Treated Adult Stria Vascularis Identifies Cell Type-Specific Regulatory Networks and Novel Therapeutic Gene Targets. PMID:34566577
KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases. PMID:34537014
Proteomic signatures of myeloid derived suppressor cells from liver and lung metastases reveal functional divergence and potential therapeutic targets. PMID:34482371
Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer. PMID:34450249
Hypotheses and facts for genetic factors related to severe COVID-19. PMID:34367930
Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells. PMID:34359681
Recent advances in drug repurposing using machine learning. PMID:34274565
Crowdsourced mapping of unexplored target space of kinase inhibitors. PMID:34083538
Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series. PMID:34046605
PhenCards: a data resource linking human phenotype information to biomedical knowledge. PMID:34034817
High ELF4 expression in human cancers is associated with worse disease outcomes and increased resistance to anticancer drugs. PMID:33836003
Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins. PMID:33808029
SmartGraph: a network pharmacology investigation platform. PMID:33430980
Genetic mechanisms of critical illness in COVID-19. PMID:33307546
An Automated Functional Annotation Pipeline That Rapidly Prioritizes Clinically Relevant Genes for Autism Spectrum Disorder. PMID:33261099
Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts. PMID:33237278
Moving targets in drug discovery. PMID:33214619
RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences. PMID:33211854
The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer. PMID:33205077
Open Targets Platform: supporting systematic drug-target identification and prioritisation. PMID:33196847
Quantitative Structure-Mutation-Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction. PMID:33183223
A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research. PMID:33173863
TCRD and Pharos 2021: mining the human proteome for disease biology. PMID:33156327
DrugCentral 2021 supports drug discovery and repositioning. PMID:33151287
Reconstructed signaling and regulatory networks identify potential drugs for SARS-CoV-2 infection. PMID:33083801
The Dark Kinase Knowledgebase: an online compendium of knowledge and experimental results of understudied kinases. PMID:33079988
PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor. PMID:32985588
Deciphering the Plasma Proteome of Type 2 Diabetes. PMID:32928870
Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs. PMID:32879140
TargetDB: A target information aggregation tool and tractability predictor. PMID:32877430
Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets. PMID:32814578
A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways. PMID:32796402
Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment. PMID:32668240
Applications of single-cell sequencing for the field of otolaryngology: A contemporary review. PMID:32596483
Homology Modeling of TMPRSS2 Yields Candidate Drugs That May Inhibit Entry of SARS-CoV-2 into Human Cells. PMID:32511288
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker. PMID:32440005
ThETA: transcriptome-driven efficacy estimates for gene-based TArget discovery. PMID:32437556
Towards the routine use of in silico screenings for drug discovery using metabolic modelling. PMID:32369553
QSAR without borders. PMID:32356548
EnrichrBot: Twitter bot tracking tweets about human genes. PMID:32277816
Ellagic Acid, Kaempferol, and Quercetin from Acacia nilotica: Promising Combined Drug With Multiple Mechanisms of Action. PMID:32226726
Exploration of databases and methods supporting drug repurposing: a comprehensive survey. PMID:32055842
Machine learning approaches and databases for prediction of drug-target interaction: a survey paper. PMID:31950972
Single Cell and Single Nucleus RNA-Seq Reveal Cellular Heterogeneity and Homeostatic Regulatory Networks in Adult Mouse Stria Vascularis. PMID:31920542
How to Illuminate the Druggable Genome Using Pharos. PMID:31898878
Novel approaches leading towards peptide GPCR de-orphanisation. PMID:31863461
Therapies for rare diseases: therapeutic modalities, progress and challenges ahead. PMID:31836861
An omics perspective on drug target discovery platforms. PMID:31774113
Pathway Commons 2019 Update: integration, analysis and exploration of pathway data. PMID:31647099
Prioritizing target-disease associations with novel safety and efficacy scoring methods. PMID:31285471
Exploring the dark genome: implications for precision medicine. PMID:31270560
In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR. PMID:31244651
Sepsis in the era of data-driven medicine: personalizing risks, diagnoses, treatments and prognoses. PMID:31190075
Geneshot: search engine for ranking genes from arbitrary text queries. PMID:31114885
Tissue-specific genes as an underutilized resource in drug discovery. PMID:31076736
Predicting synthetic lethal interactions using conserved patterns in protein interaction networks. PMID:30995217
Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder. PMID:30877270
Assessing the public landscape of clinical-stage pharmaceuticals through freely available online databases. PMID:30690196
A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. PMID:30518210
Open Targets Platform: new developments and updates two years on. PMID:30462303
Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data. PMID:30450911
ChEMBL: towards direct deposition of bioassay data. PMID:30398643
DrugThatGene: integrative analysis to streamline the identification of druggable genes, pathways and protein complexes from CRISPR screens. PMID:30395160
DrugCentral 2018: an update. PMID:30371892
Network, Transcriptomic and Genomic Features Differentiate Genes Relevant for Drug Response. PMID:30319692
Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation. PMID:30303482
Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands. PMID:30285606
A Pharmacochaperone-Based High-Throughput Screening Assay for the Discovery of Chemical Probes of Orphan Receptors. PMID:30251873
Identification of Novel Target for Osteosarcoma by Network Analysis. PMID:30144309
Integrative landscape of dysregulated signaling pathways of clinically distinct pancreatic cancer subtypes. PMID:30018740
Genetic-Driven Druggable Target Identification and Validation. PMID:29803319
How to Achieve Better Results Using PASS-Based Virtual Screening: Case Study for Kinase Inhibitors. PMID:29755970
Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources. PMID:29695735
Current Challenges and Opportunities in Treating Glioblastoma. PMID:29669750
Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer. PMID:29643987
TISSUES 2.0: an integrative web resource on mammalian tissue expression. PMID:29617745
Drug Repositioning in Glioblastoma: A Pathway Perspective. PMID:29615902
Unexplored therapeutic opportunities in the human genome. PMID:29472638
Glimmers in illuminating the druggable genome. PMID:29348682
Drug target ontology to classify and integrate drug discovery data. PMID:29122012
Evidence-Based Precision Oncology with the Cancer Targetome. PMID:28964549
Computational Approaches to Identify Genetic Interactions for Cancer Therapeutics. PMID:28941356
Using ChEMBL web services for building applications and data processing workflows relevant to drug discovery. PMID:28602100
Bioinformatics in translational drug discovery. PMID:28487472
TIN-X: target importance and novelty explorer. PMID:28398460
The ChEMBL database in 2017. PMID:27899562
Tags:
Tags
More detailed information about this field from each metasource.
disease
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
disease phenotype
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
function analysis
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
gene-disease association
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
molecular interaction
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
phenotype
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
protein interaction
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
protein localization
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
protein name
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
protein targeting
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
sequence annotation
metasource: Fairsharing.org
version: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Tags
More detailed information about this field from each metasource.
disease
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
disease phenotype
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
function analysis
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
gene-disease association
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
molecular interaction
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
phenotype
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
protein interaction
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
protein localization
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
protein name
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
protein targeting
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
sequence annotation
metasource: Fairsharing.orgversion: FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: May 20, 2021, 1:50 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
disease disease phenotype function analysis gene-disease association molecular interaction phenotype protein interaction protein localization protein name protein targeting sequence annotation
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