Patient Derived Xenograft Minimum Information
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Patient Derived Xenograft Minimum Information
metasource: Fairsharing.org
version: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
PDX-MI
metasource: Fairsharing.org
version: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
Names
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Patient Derived Xenograft Minimum Information
metasource: Fairsharing.orgversion: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
PDX-MI
metasource: Fairsharing.orgversion: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
Names
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Patient Derived Xenograft Minimum Information
metasource: Fairsharing.orgversion: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
PDX-MI
metasource: Fairsharing.orgversion: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
Patients-derived tumor xenograft (PDX) mouse models are an important oncology research platform to study tumor evolution, drug response and personalised medicine approaches. We identified critical attributes to accurately describe PDX production and usage and proposed the PDX-Minimum information (PDX-MI) standard, which defines the minimal information for describing the clinical attributes of a patient’s tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use PDX models in cancer research. PDX-MI standard is the result of the collaborative work from more than 50 worldwide experts over 30 worldwide institutions.
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Patients-derived tumor xenograft (PDX) mouse models are an important oncology research platform to study tumor evolution, drug response and personalised medicine approaches. We identified critical attributes to accurately describe PDX production and usage and proposed the PDX-Minimum information (PDX-MI) standard, which defines the minimal information for describing the clinical attributes of a patient’s tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use PDX models in cancer research. PDX-MI standard is the result of the collaborative work from more than 50 worldwide experts over 30 worldwide institutions.
metasource: Fairsharing.orgversion: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
Webpage:
https://www.ncbi.nlm.nih.gov/pubmed/29092942Webpage
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https://www.ncbi.nlm.nih.gov/pubmed/29092942
metasource: Fairsharing.orgversion: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
Publications:
Publications
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PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models
PMID: 29092942
metasource: Fairsharing.org
version: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
Publications
More detailed information about this field from each metasource.
PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models
PMID: 29092942
metasource: Fairsharing.org
version: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
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PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models
PubMed citations: 48.
48 articles citing: PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models
In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts. PMID:35697909
Advanced Immune Cell Profiling by Multiparameter Flow Cytometry in Humanized Patient-Derived Tumor Mice. PMID:35565343
PDXNet portal: patient-derived Xenograft model, data, workflow and tool discovery. PMID:35475145
Patient-Derived In Vitro and In Vivo Models of Cancer. PMID:35230691
The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization. PMID:35193494
The HROC-Xenobank-A High Quality Assured PDX Biobank of >100 Individual Colorectal Cancer Models. PMID:34884989
Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions. PMID:34771558
MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity. PMID:34725485
Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment. PMID:34429404
Translation of DNA Damage Response Inhibitors as Chemoradiation Sensitizers From the Laboratory to the Clinic. PMID:34348175
Preclinical models as patients' avatars for precision medicine in colorectal cancer: past and future challenges. PMID:34090508
Patient-derived tumor models: a more suitable tool for pre-clinical studies in colorectal cancer. PMID:34074330
Spontaneous mouse lymphoma in patient-derived tumor xenografts: The importance of systematic analysis of xenografted human tumor tissues in preclinical efficacy trials. PMID:34051622
Preclinical In Vivo Modeling of Pediatric Sarcoma-Promises and Limitations. PMID:33918045
Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas. PMID:33837665
The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma. PMID:33808071
Characterization of the large-scale Japanese patient-derived xenograft (J-PDX) library. PMID:33759313
Design and Implementation of the Pre-Clinical DICOM Standard in Multi-Cohort Murine Studies. PMID:33681459
Patient Derived Xenografts for Genome-Driven Therapy of Osteosarcoma. PMID:33671173
Enhanced Viability for Ex vivo 3D Hydrogel Cultures of Patient-Derived Xenografts in a Perfused Microfluidic Platform. PMID:33346184
Functional characterization of androgen receptor in two patient-derived xenograft models of triple negative breast cancer. PMID:33271252
Phase II trial of ribociclib and letrozole in patients with relapsed oestrogen receptor-positive ovarian or endometrial cancers. PMID:33109627
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology. PMID:33009951
The ongoing trends of patient-derived xenograft models in oncology. PMID:32954687
Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells. PMID:32923140
Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine. PMID:32879897
Report of the use of patient-derived xenograft models in the development of anticancer drugs in Japan. PMID:32639672
Innovations, challenges, and minimal information for standardization of humanized mice. PMID:32578942
Leveraging Patient-Derived Models for Immunotherapy Research. PMID:32511030
Metastatic Melanoma Patient-Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition. PMID:32234759
PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma. PMID:32075097
The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer. PMID:32060098
Patient-Derived Orthotopic Xenograft Models of Pediatric Brain Tumors: In a Mature Phase or Still in Its Infancy? PMID:31970083
Assessment of IFNγ responsiveness in patient-derived xenografts. PMID:31948560
Humanized Mice as an Effective Evaluation System for Peptide Vaccines and Immune Checkpoint Inhibitors. PMID:31888191
Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A. PMID:31751381
Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research. PMID:31500168
Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research. PMID:31197363
A Melanoma Patient-Derived Xenograft Model. PMID:31157772
Systematic Review of Patient-Derived Xenograft Models for Preclinical Studies of Anti-Cancer Drugs in Solid Tumors. PMID:31064068
Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-derived xenografts. PMID:31004097
3D models in the new era of immune oncology: focus on T cells, CAF and ECM. PMID:30898166
PDX Finder: A portal for patient-derived tumor xenograft model discovery. PMID:30535239
A patient derived xenograft model of cervical cancer and cervical dysplasia. PMID:30365542
A comprehensively revised strategy that improves the specific activity and long-term stability of clinically relevant 89Zr-immuno-PET agents. PMID:30178793
FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation. PMID:30046001
Patient-derived xenograft models in musculoskeletal malignancies. PMID:29688859
ImmPort, toward repurposing of open access immunological assay data for translational and clinical research. PMID:29485622
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cancer
metasource: Fairsharing.org
version: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
model organism
metasource: Fairsharing.org
version: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
Tags
More detailed information about this field from each metasource.
cancer
metasource: Fairsharing.orgversion: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
model organism
metasource: Fairsharing.orgversion: FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Jan 03 2022 7:11 p.m.
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