MedPix® is a free open-access online database of medical images, teaching cases, and clinical topics, integrating images and textual metadata including over 12,000 patient case scenarios, 9,000 topics, and nearly 59,000 images. Our primary target audience includes physicians and nurses, allied health professionals, medical students, nursing students and others interested in medical knowledge. The content material is organized by disease location (organ system); pathology category; patient profiles; and, by image classification and image captions. The collection is searchable by patient symptoms and signs, diagnosis, organ system, image modality and image description, keywords, contributing authors, and many other search options.