PIWI-Interacting RNA (piRNA) and Epigenetic Editing in Environmental Health Sciences.
PMID:35917009
Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model.
PMID:35675330
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans.
PMID:35551368
Partial and complete loss of myosin binding protein H-like cause cardiac conduction defects.
PMID:35533732
From Reductionism Toward Integration: Understanding How Social Behavior Emerges From Integrated Circuits.
PMID:35431824
SGII: Systematic Identification of Essential lncRNAs in Mouse and Human Genome With lncRNA-Protein-Protein Heterogeneous Interaction Network.
PMID:35386279
Why rare disease needs precision medicine-and precision medicine needs rare disease.
PMID:35243424
The mouse resource at National Resource Center for Mutant Mice.
PMID:35138443
SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model.
PMID:35065421
Progress towards completing the mutant mouse null resource.
PMID:34698892
Tip60 might be a candidate for the acetylation of hepatic carbonic anhydrase I and III in mice.
PMID:34651296
Path to improving the life cycle and quality of genome-scale models of metabolism.
PMID:34555324
Strategies to Uplift Novel Mendelian Gene Discovery for Improved Clinical Outcomes.
PMID:34220947
Using "-omics" Data to Inform Genome-wide Association Studies (GWASs) in the Osteoporosis Field.
PMID:34125409
Loss of growth hormone signaling in the mouse germline or in adulthood reduces islet mass and alters islet function with notable sex differences.
PMID:33938235
Differential effects by sex with Kmt5b loss.
PMID:33871180
A resource of targeted mutant mouse lines for 5,061 genes.
PMID:33833456
Efficient collection of a large number of mutations by mutagenesis of DNA damage response defective animals.
PMID:33828169
MaveRegistry: a collaboration platform for multiplexed assays of variant effect.
PMID:33774657
Hypoglossal Nerve Abnormalities as Biomarkers for Central Nervous System Defects in Mouse Lines Producing Embryonically Lethal Offspring.
PMID:33584208
Male-derived copulatory plugs enhance implantation success in female Mus musculus.
PMID:33355341
A most formidable arsenal: genetic technologies for building a better mouse.
PMID:33004485
A Single Test to Study Social Behavior and Repetitive Self-grooming in Mice.
PMID:32699808
Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation.
PMID:32646486
Translational Geroscience: From invertebrate models to companion animal and human interventions.
PMID:32368707
Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.
PMID:31833031
Identifying gene function and module connections by the integration of multispecies expression compendia.
PMID:31754022
High-mobility group nucleosomal binding domain 2 protects against microcephaly by maintaining global chromatin accessibility during corticogenesis.
PMID:31699896
Genetic backgrounds have unique seizure response profiles and behavioral outcomes following convulsant administration.
PMID:31698263
A Genocentric Approach to Discovery of Mendelian Disorders.
PMID:31668702
Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions.
PMID:31524598
Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.
PMID:31446895
The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthood.
PMID:31204062
The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics.
PMID:31133849
Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography.
PMID:31063133
Robust mouse tracking in complex environments using neural networks.
PMID:30937403
Ontology-based validation and identification of regulatory phenotypes.
PMID:30423068
Chimeric Mouse Generation by ES Cell Blastocyst Microinjection and Uterine Transfer.
PMID:30353510
Understanding Tendons: Lessons from Transgenic Mouse Models.
PMID:29978741
Trans-inner Cell Mass Injection of Embryonic Stem Cells Leads to Higher Chimerism Rates.
PMID:29912196
Immunity against the Obligate Intracellular Bacterial Pathogen Rickettsia australis Requires a Functional Complement System.
PMID:29581196
Aminode: Identification of Evolutionary Constraints in the Human Proteome.
PMID:29358731
Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease.
PMID:29180785
Emerging and evolving concepts in gene essentiality.
PMID:29033457
Highly Variable Genomic Landscape of Endogenous Retroviruses in the C57BL/6J Inbred Strain, Depending on Individual Mouse, Gender, Organ Type, and Organ Location.
PMID:28951865
Differences in bone structure and unloading-induced bone loss between C57BL/6N and C57BL/6J mice.
PMID:28913652
Mouse models of human ocular disease for translational research.
PMID:28859131
Mouse Genome Informatics (MGI) Resource: Genetic, Genomic, and Biological Knowledgebase for the Laboratory Mouse.
PMID:28838066
Phenotyping cardiac and structural birth defects in fetal and newborn mice.
PMID:28544620
Integrative Physiology: At the Crossroads of Nutrition, Microbiota, Animal Physiology, and Human Health.
PMID:28273475
CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene.
PMID:28195201
A simple DNA recombination screening method by RT-PCR as an alternative to Southern blot.
PMID:28105543
Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein.
PMID:27905063
An improved Red/ET recombineering system and mouse ES cells culture conditions for the generation of targeted mutant mice.
PMID:27890869
Mouse-based genetic modeling and analysis of Down syndrome.
PMID:27789459
Redefining 'stress resistance genes', and why it matters.
PMID:27702993
Whole-Organism Cellular Pathology: A Systems Approach to Phenomics.
PMID:27503355
Copulatory plugs inhibit the reproductive success of rival males.
PMID:27488082
PiggyBac transposon-based polyadenylation-signal trap for genome-wide mutagenesis in mice.
PMID:27292714
Update of neurotrophic factors in neurobiology of addiction and future directions.
PMID:27189755
Gene Targeting Using Homologous Recombination in Embryonic Stem Cells: The Future for Behavior Genetics?
PMID:27148349
The genetics of bone mass and susceptibility to bone diseases.
PMID:27052486
Genomic landscapes of endogenous retroviruses unveil intricate genetics of conventional and genetically-engineered laboratory mouse strains.
PMID:26779669
Endothelial Cell Surface Expressed Chemotaxis and Apoptosis Regulator (ECSCR) Regulates Lipolysis in White Adipocytes via the PTEN/AKT Signaling Pathway.
PMID:26692198
The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.
PMID:26664249
Assessment of Full-Eye Response to Osmotic Stress in Mouse Model In Vivo Using Optical Coherence Tomography.
PMID:26491552
Linking RNA biology to lncRNAs.
PMID:26430155
Comprehensive comparative homeobox gene annotation in human and mouse.
PMID:26412852
[Application Progress of CRISPR/Cas9 System for Gene Editing in Tumor Research].
PMID:26383982
Beyond knockouts: the International Knockout Mouse Consortium delivers modular and evolving tools for investigating mammalian genes.
PMID:26340938
Applications of comparative evolution to human disease genetics.
PMID:26338499
Network Modules of the Cross-Species Genotype-Phenotype Map Reflect the Clinical Severity of Human Diseases.
PMID:26301634
High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.
PMID:26273529
Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.
PMID:26163370
Publisher’s Note:Abstraction for data integration:Fusing mammalian molecular, cellular and phenotype big datasets for better knowledge extraction.
PMID:26101093
Gene Perturbation Atlas (GPA): a single-gene perturbation repository for characterizing functional mechanisms of coding and non-coding genes.
PMID:26039571
Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain.
PMID:26034286
Advantages of using the CRISPR/Cas9 system of genome editing to investigate male reproductive mechanisms using mouse models.
PMID:25994645
A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis.
PMID:25875095
Common Polymorphisms in the Age of Research Domain Criteria (RDoC): Integration and Translation.
PMID:25680673
Association of novelty-related behaviors and intravenous cocaine self-administration in Diversity Outbred mice.
PMID:25238945
Generation of Ugt1-deficient murine liver cell lines using TALEN technology.
PMID:25118822
Integrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associations.
PMID:24949630
Automated pipeline for anatomical phenotyping of mouse embryos using micro-CT.
PMID:24850858
Colorectal polyp model established by transplacental BMP4 RNAi.
PMID:24806485
Fighting in the home cage: Agonistic encounters and effects on neurobiological markers within the social decision-making network of house mice (Mus musculus).
PMID:24602985
Rationally optimized cryopreservation of multiple mouse embryonic stem cell lines: II--Mathematical prediction and experimental validation of optimal cryopreservation protocols.
PMID:24560712
Automatic structural parcellation of mouse brain MRI using multi-atlas label fusion.
PMID:24475148
Rationally optimized cryopreservation of multiple mouse embryonic stem cell lines: I--Comparative fundamental cryobiology of multiple mouse embryonic stem cell lines and the implications for embryonic stem cell cryopreservation protocols.
PMID:24384367
Transgenic mouse technology in skin biology: generation of complete or tissue-specific knockout mice.
PMID:24352082
Newer gene editing technologies toward HIV gene therapy.
PMID:24284874
Pheno-Pub: a total support system for the publication of mouse phenotypic data on the web.
PMID:24220852
Mouse models in bone marrow transplantation and adoptive cellular therapy.
PMID:24216170
The roles of FMRP-regulated genes in autism spectrum disorder: single- and multiple-hit genetic etiologies.
PMID:24207117
Genetically engineered humanized mouse models for preclinical antibody studies.
PMID:24150980
MADM-ML, a mouse genetic mosaic system with increased clonal efficiency.
PMID:24143253
AMP deaminase 3 deficiency enhanced 5'-AMP induction of hypometabolism.
PMID:24066180
Phenotypic characterization of the KK/HlJ inbred mouse strain.
PMID:24009271
The perfect host: a mouse host embryo facilitating more efficient germ line transmission of genetically modified embryonic stem cells.
PMID:23844102
Pancreas-specific Cre driver lines and considerations for their prudent use.
PMID:23823474
What have we learned from murine models of otitis media?
PMID:23775349
Microcomputed tomography provides high accuracy congenital heart disease diagnosis in neonatal and fetal mice.
PMID:23759365
Improving the measurement of semantic similarity between gene ontology terms and gene products: insights from an edge- and IC-based hybrid method.
PMID:23741529
High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases.
PMID:23630316
Going forward with genetics: recent technological advances and forward genetics in mice.
PMID:23608223
Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice.
PMID:23499256
Efficient methods for targeted mutagenesis in zebrafish using zinc-finger nucleases: data from targeting of nine genes using CompoZr or CoDA ZFNs.
PMID:23451191
A novel selection marker for efficient DNA cloning and recombineering in E. coli.
PMID:23437314
Genetic disruption of the copulatory plug in mice leads to severely reduced fertility.
PMID:23341775
Murine infection models for vaccine development: the malaria example.
PMID:23249712
Deconstructing Mus gemischus: advances in understanding ancestry, structure, and variation in the genome of the laboratory mouse.
PMID:23223940
Using genetically engineered animal models in the postgenomic era to understand gene function in alcoholism.
PMID:23134044
A fast and sensitive alternative for β-galactosidase detection in mouse embryos.
PMID:23132248
The mammalian gene function resource: the International Knockout Mouse Consortium.
PMID:22968824
The Mammalian Phenotype Ontology as a unifying standard for experimental and high-throughput phenotyping data.
PMID:22961259
Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.
PMID:22961258
Centralized mouse repositories.
PMID:22945696
Permissive and restricted virus infection of murine embryonic stem cells.
PMID:22815272
Conditional gene manipulation: Cre-ating a new biological era.
PMID:22761243
Rapid and cost-effective gene targeting in rat embryonic stem cells by TALENs.
PMID:22749015
Experimental and husbandry procedures as potential modifiers of the results of phenotyping tests.
PMID:22713295
Regulated Expression of Chromobox Homolog 5 Revealed in Tumors of Apc(Min) (/+) ROSA11 Gene Trap Mice.
PMID:22670227
Dynamic gene expression in the human cerebral cortex distinguishes children from adults.
PMID:22666384
A resource for the conditional ablation of microRNAs in the mouse.
PMID:22570807
Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development.
PMID:22553207
Elephant transcriptome provides insights into the evolution of eutherian placentation.
PMID:22546564
Conditional gene expression in the mouse inner ear using Cre-loxP.
PMID:22526732
Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs.
PMID:22492512
Mixture of differentially tagged Tol2 transposons accelerates conditional disruption of a broad spectrum of genes in mouse embryonic stem cells.
PMID:22447447
Mouse genetic and phenotypic resources for human genetics.
PMID:22422677
Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation.
PMID:22282595
The blessings and curses of C57BL/6 substrains in mouse genetic studies.
PMID:22211972
A knockout mouse resource for the biomedical research community.
PMID:22211970
GeneWeaver: a web-based system for integrative functional genomics.
PMID:22080549
Optical Coherence Tomography for live imaging of mammalian development.
PMID:21962442
Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice.
PMID:21931844
BioMart as an integration solution for the International Knockout Mouse Consortium.
PMID:21930503
Mouse models for Down syndrome-associated developmental cognitive disabilities.
PMID:21865664
A resource of vectors and ES cells for targeted deletion of microRNAs in mice.
PMID:21822254
The future of model organisms in human disease research.
PMID:21765459
Identification of fat4 and tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas.
PMID:21764761
Cyto- and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: a study of immunostaining and multiple fluorescent tract tracing.
PMID:21674499
Charting a course for genomic medicine from base pairs to bedside.
PMID:21307933
Bi-allelic gene targeting in mouse embryonic stem cells.
PMID:21288739
Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.
PMID:21204268
Mouse mutants and phenotypes: accessing information for the study of mammalian gene function.
PMID:21185380
New genetic resources for mammalian developmental biologists.
PMID:21173845
Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions.
PMID:21170304
Laboratory mouse models for the human genome-wide associations.
PMID:21072174
Mouse models in male fertility research.
PMID:21057516
The UCSC Genome Browser database: update 2011.
PMID:20959295
Molecular networks in drug discovery.
PMID:20932236
The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium.
PMID:20929875
High-sensitivity O-glycomic analysis of mice deficient in core 2 {beta}1,6-N-acetylglucosaminyltransferases.
PMID:20855471
Functional phenotyping of the maternal albumin turnover in the mouse placenta by dynamic contrast-enhanced MRI.
PMID:20686857
ROSA26Flpo deleter mice promote efficient inversion of conditional gene traps in vivo.
PMID:20665730
MamPhEA: a web tool for mammalian phenotype enrichment analysis.
PMID:20605928
Efficient generation of germ line transmitting chimeras from C57BL/6N ES cells by aggregation with outbred host embryos.
PMID:20582321
A mouse knockout library for secreted and transmembrane proteins.
PMID:20562862
Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice.
PMID:20512340
Multi-scale characterization of the PEPCK-C mouse through 3D cryo-imaging.
PMID:20467563
Contrasting genetic paths to morphological and physiological evolution.
PMID:20368429
Genetically modified mice-successes and failures of a widely used technology.
PMID:20140450
Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis.
PMID:20124436
Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach.
PMID:20124353
The mammalian phenotype ontology: enabling robust annotation and comparative analysis.
PMID:20052305
High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains.
PMID:19958391
The UCSC Genome Browser database: update 2010.
PMID:19906737
Transgenic mouse technology: principles and methods.
PMID:19763515
Where's the mouse info?
PMID:19605899
Male infertility caused by spermiogenic defects: lessons from gene knockouts.
PMID:19481682
Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling.
PMID:19434078
Genetic architecture of quantitative traits in mice, flies, and humans.
PMID:19411597
Reconstructing generalized logical networks of transcriptional regulation in mouse brain from temporal gene expression data.
PMID:19300527
Cancer gene discovery in mouse and man.
PMID:19285540
Mouse models for human otitis media.
PMID:19272362
Elevated plus maze for mice.
PMID:19229173
PRIME importance of pathology expertise.
PMID:19131991
Removing the cloak of invisibility: phenotyping the mouse.
PMID:19048073
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
PMID:18799693
Search for informative polymorphisms in candidate genes: clock genes and circadian behaviour in blue tits.
PMID:18792794
Genetically engineered mouse models for skin research: taking the next step.
PMID:18511240
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study.
PMID:18505770
Null mutations in human and mouse orthologs frequently result in different phenotypes.
PMID:18458337
Genetic background determines metabolic phenotypes in the mouse.
PMID:18392653
Optimization of volumetric computed tomography for skeletal analysis of model genetic organisms.
PMID:18286615
An improved cryopreservation method for a mouse embryonic stem cell line.
PMID:18191827
Reduced body weight is a common effect of gene knockout in mice.
PMID:18182103
Mutagenesis in rodents using the L1 retrotransposon.
PMID:18047693
'One medicine---one pathology': are veterinary and human pathology prepared?
PMID:18040269
Virtues and limitations of the preimplantation mouse embryo as a model system.
PMID:18023855
The UniTrap resource: tools for the biologist enabling optimized use of gene trap clones.
PMID:17942430
PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice.
PMID:17932058
Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line.
PMID:17828574
Large-scale, saturating insertional mutagenesis of the mouse genome.
PMID:17720809
Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
PMID:17660561
Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions.
PMID:17640903
Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.
PMID:17637833
Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease.
PMID:17514509
BAC to immunology--bacterial artificial chromosome-mediated transgenesis for targeting of immune cells.
PMID:17437533
A recombineering based approach for high-throughput conditional knockout targeting vector construction.
PMID:17426124
Adopting the good reFLEXes when generating conditional alterations in the mouse genome.
PMID:17415672
Induced mitotic recombination of p53 in vivo.
PMID:17360553
Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM).
PMID:17360552
Developmental and adult phenotyping directly from mutant embryonic stem cells.
PMID:17360545
Interpretation of knockout experiments: the congenic footprint.
PMID:17331107
Assessing human germ-cell mutagenesis in the Postgenome Era: a celebration of the legacy of William Lawson (Bill) Russell.
PMID:17295306
Power matters in closing the phenotyping gap.
PMID:17216184
Using mouse genomics to understand idiopathic interstitial fibrosis.
PMID:17202297
Mutagenesis of diploid mammalian genes by gene entrapment.
PMID:17062627
Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness.
PMID:17044014
Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays.
PMID:16942609
Understanding mammalian genetic systems: the challenge of phenotyping in the mouse.
PMID:16933996
Mouse models as a tool to unravel the genetic basis for human otitis media.
PMID:16917982
Modeling chromosomes in mouse to explore the function of genes, genomic disorders, and chromosomal organization.
PMID:16839184
Tslc1 (nectin-like molecule-2) is essential for spermatozoa motility and male fertility.
PMID:16837733
Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder?
PMID:16797265
Virtual histology of transgenic mouse embryos for high-throughput phenotyping.
PMID:16683035
Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells.
PMID:16679411
Learning from small fry: the zebrafish as a genetic model organism for aquaculture fish species.
PMID:16670967
Finding the molecular basis of complex genetic variation in humans and mice.
PMID:16524828
Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice.
PMID:16519954
Integration of double-fluorescence expression vectors into zebrafish genome for the selection of site-directed knockout/knockin.
PMID:16501876
Conditional and inducible gene recombineering in the mouse inner ear.
PMID:16488403
High-throughput trapping of secretory pathway genes in mouse embryonic stem cells.
PMID:16478711
Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice.
PMID:16450009
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse.
PMID:16381950
Rapid and quantitative detection of homologous and non-homologous recombination events using three oligonucleotide MLPA.
PMID:16340005
Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice.
PMID:16300676
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
PMID:16260493
Two ways to trap a gene in mice.
PMID:16150712
Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference.
PMID:15987787
Adding precision tools to the plant biologists' toolbox with chemical genomics.
PMID:15955916
Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression.
PMID:15939868
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.
PMID:15870191
The problem with academic medicine: engineering our way into and out of the mess.
PMID:15839728
Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cells.
PMID:15687378
The Mammalian Phenotype Ontology as a tool for annotating, analyzing and comparing phenotypic information.
PMID:15642099
Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique.
PMID:15615595
All systems GO for understanding mouse gene function.
PMID:15610553
The European dimension for the mouse genome mutagenesis program.
PMID:15340424