Deciphering the Mechanisms of Developmental Disorders
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Deciphering the Mechanisms of Developmental Disorders
metasource: Fairsharing.org
version: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
DMDD
metasource: Fairsharing.org
version: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Names
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Deciphering the Mechanisms of Developmental Disorders
metasource: Fairsharing.orgversion: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
DMDD
metasource: Fairsharing.orgversion: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Names
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Deciphering the Mechanisms of Developmental Disorders
metasource: Fairsharing.orgversion: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
DMDD
metasource: Fairsharing.orgversion: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Initiated in 2013, DMDD has the ambitious goal of identifying all embryonic lethal knockout lines made at the Wellcome Trust Sanger institute, through their work as a major centre for creation of individual mouse gene knockouts. DMDD uses a combination of comprehensive 3D imaging, tissue histology, immunocytochemistry and transcriptomics to identify abnormalities in embryo and placental structure for each embryonic lethal line. All data is made freely available via this web site, enabling individual researchers to identify lines relevant to their own research. The DMDD programme is coordinating its work with similar international efforts through the umbrella of the International Mouse Phenotyping Consortium.
Description
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Initiated in 2013, DMDD has the ambitious goal of identifying all embryonic lethal knockout lines made at the Wellcome Trust Sanger institute, through their work as a major centre for creation of individual mouse gene knockouts. DMDD uses a combination of comprehensive 3D imaging, tissue histology, immunocytochemistry and transcriptomics to identify abnormalities in embryo and placental structure for each embryonic lethal line. All data is made freely available via this web site, enabling individual researchers to identify lines relevant to their own research. The DMDD programme is coordinating its work with similar international efforts through the umbrella of the International Mouse Phenotyping Consortium.
metasource: Fairsharing.orgversion: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
The Deciphering the Mechanisms of Developmental Disorders (DMDD) consortium is a research programme set up to identify genes in the mouse, which if mutated (or knocked-out) result in embryonic lethality when homozygous, and initiate the study of why disruption of their function has such profound effects on embryo development and survival. The goal of the project is to identify animal models useful for investigating the basis of human developmental disorders. The project uses a combination of comprehensive high resolution 3D imaging and tissue histology to identify abnormalities in embryo and placental structures of embryonic lethal lines. All the image data from the embryos and placenta we have studied and the phenotypes we have observed can be viewed and searched through the DMDD project website.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Webpage:
https://dmdd.org.ukWebpage
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https://dmdd.org.uk
metasource: Fairsharing.orgversion: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://dmdd.org.uk
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Licence:
Name: Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)Licence name
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Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)
metasource: Fairsharing.orgversion: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
Licence URL
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https://creativecommons.org/licenses/by-nc-sa/3.0/
metasource: Fairsharing.orgversion: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
Publications:
Publications
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Deciphering the mechanisms of developmental disorders: phenotype analysis of embryos from mutant mouse lines
PMID: 26519470
metasource: Fairsharing.org
version: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://dx.doi.org/10.1093/nar/gkv1138
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
More detailed information about this field from each metasource.
Deciphering the mechanisms of developmental disorders: phenotype analysis of embryos from mutant mouse lines
PMID: 26519470
metasource: Fairsharing.org
version: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
http://dx.doi.org/10.1093/nar/gkv1138
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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Deciphering the mechanisms of developmental disorders: phenotype analysis of embryos from mutant mouse lines
PubMed citations: 17.
17 articles citing: Deciphering the mechanisms of developmental disorders: phenotype analysis of embryos from mutant mouse lines
Morphogenesis of the Mammalian Aortic Arch Arteries. PMID:35620058
Artefacts in Volume Data Generated with High Resolution Episcopic Microscopy (HREM). PMID:34829939
The venous system of E14.5 mouse embryos-reference data and examples for diagnosing malformations in embryos with gene deletions. PMID:34435363
Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre. PMID:34078907
Hypoglossal Nerve Abnormalities as Biomarkers for Central Nervous System Defects in Mouse Lines Producing Embryonically Lethal Offspring. PMID:33584208
LAMA: automated image analysis for the developmental phenotyping of mouse embryos. PMID:33574040
The Col4a2em1(IMPC)Wtsi mouse line: lessons from the Deciphering the Mechanisms of Developmental Disorders program. PMID:31331924
Common and distinct transcriptional signatures of mammalian embryonic lethality. PMID:31243271
Visualising the Cardiovascular System of Embryos of Biomedical Model Organisms with High Resolution Episcopic Microscopy (HREM). PMID:30558275
Placentation defects are highly prevalent in embryonic lethal mouse mutants. PMID:29539633
Three-dimensional microCT imaging of murine embryonic development from immediate post-implantation to organogenesis: application for phenotyping analysis of early embryonic lethality in mutant animals. PMID:29170794
Morphology, topology and dimensions of the heart and arteries of genetically normal and mutant mouse embryos at stages S21-S23. PMID:28776665
High-resolution Episcopic Microscopy (HREM) - Simple and Robust Protocols for Processing and Visualizing Organic Materials. PMID:28715372
X-ray phase microtomography with a single grating for high-throughput investigations of biological tissue. PMID:28271016
Leveraging Online Resources to Prioritize Candidate Genes for Functional Analyses: Using the Fetal Testis as a Test Case. PMID:28196369
A bioimage informatics platform for high-throughput embryo phenotyping. PMID:27742664
The 2016 database issue of Nucleic Acids Research and an updated molecular biology database collection. PMID:26740669 - http://dx.doi.org/10.1093/nar/gkv1138
Tags:
Tags
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disease phenotype
metasource: Fairsharing.org
version: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
imaging
metasource: Fairsharing.org
version: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
human and other vertebrate genomes
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
model organisms, comparative genomics
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Tags
More detailed information about this field from each metasource.
disease phenotype
metasource: Fairsharing.orgversion: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
imaging
metasource: Fairsharing.orgversion: FAIRsharing.org: DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI: https://doi.org/10.25504/FAIRsharing.p5f1j4; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 03 2022 7:08 p.m.
human and other vertebrate genomes
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
model organisms, comparative genomics
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
disease phenotype imaging human and other vertebrate genomes model organisms
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