DRSC Functional Genomics Resources
Names
More detailed information about this field from each metasource.
DRSC Functional Genomics Resources
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
DRSC-FGR
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
FlyRNAi
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:45.497298
flyrnai
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:45.497298
Names
More detailed information about this field from each metasource.
DRSC Functional Genomics Resources
metasource: Fairsharing.orgversion: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
DRSC-FGR
metasource: Fairsharing.orgversion: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
FlyRNAi
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:45.497298
flyrnai
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:45.497298
Other names: DRSC-FGR, FlyRNAi, flyrnai
Names
More detailed information about this field from each metasource.
DRSC Functional Genomics Resources
metasource: Fairsharing.orgversion: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
DRSC-FGR
metasource: Fairsharing.orgversion: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
FlyRNAi
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:45.497298
flyrnai
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:45.497298
DRSC Functional Genomics Resources (DRSC-FGR) began as the Drosophila RNAi Screening Center (DRSC), founded by Prof. Norbert Perrimon in 2003, and the Transgenic RNAi Project (TRiP), founded by Prof. Perrimon in 2008. DRSC-FGR has been previously known as flyRNAi.org. It has since grown into a functional genomics platform meeting the needs of the Drosophila and broader community.
Description
More detailed information about this field from each metasource.
DRSC Functional Genomics Resources (DRSC-FGR) began as the Drosophila RNAi Screening Center (DRSC), founded by Prof. Norbert Perrimon in 2003, and the Transgenic RNAi Project (TRiP), founded by Prof. Perrimon in 2008. DRSC-FGR has been previously known as flyRNAi.org. It has since grown into a functional genomics platform meeting the needs of the Drosophila and broader community.
metasource: Fairsharing.orgversion: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
RNA interference (RNAi) has become a powerful tool for genetic screening in Drosophila. At the Drosophila RNAi Screening Center (DRSC), we are using a library of over 21,000 dsRNAs targeting known and predicted genes in Drosophila. This library is available for the use of visiting scientists wishing to perform full-genome RNAi screens. The data generated from these screens is collected in the DRSC database (http://flyRNAi.org/cgi-bin/RNAi_screens.pl) in a flexible format for the convenience of the scientist and for archiving data. The long-term goal of this database is to provide annotations for as many of the uncharacterized genes in Drosophila as possible. Data from published screens are available to the public through a highly configurable interface that allows detailed examination of the data and provides access to a number of other databases and bioinformatics tools. Screening at the DRSC Visiting scientists typically perform their screens in duplicate - screening against two full-genome sets. Raw data from duplicate genome sets are collected along with phenotype and "hit" information. The scientists have password-protected accounts which give them access to data entry interfaces and direct links to their personal data, both published and unpublished. The logged in user also has access to some tools for viewing data a plate at a time, direct links to the bioinformatic tools (listed below), and functions for directly querying the quality control (QC) information for the source plates. Website Overview The public database begins with a page listing all published screens that have been done at the DRSC. From there, the experimental data for each assay may be viewed in a configurable table. Where possible, links to the published papers and supplementary data are also provided. Also on the starting page are links to various informatic tools, a gene lookup function which provides extensive amplicon data, and a list of completed, but not yet published, screens.
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Database of Dorsophila RNA interference (RNAi) Screening Center.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:45.497298
Webpage:
http://www.flyrnai.org/Webpage
More detailed information about this field from each metasource.
http://www.flyrnai.org/
metasource: Fairsharing.orgversion: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:45.497298
http://flyRNAi.org/
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
Publications:
(11)
Publications
More detailed information about this field from each metasource.
An integrative approach to ortholog prediction for disease-focused and other functional studies
PMID: 21880147
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
A Drosophila resource of transgenic RNAi lines for neurogenetics
PMID: 19487563
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster
PMID: 18084299
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
Genomic screening with RNAi: results and challenges
PMID: 20367032
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays
PMID: 16964256
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
Design and implementation of high-throughput RNAi screens in cultured Drosophila cells
PMID: 17853882
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
FlyRNAi: the Drosophila RNAi screening center database
PMID: 16381918
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update
PMID: 22067456
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:45.497298
False negative rates in Drosophila cell-based RNAi screens: a case study
PMID: 21251254
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
Cross-species RNAi rescue platform in Drosophila melanogaster
PMID: 19720858
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
https://doi.org/10.1093/nar/gkaa936
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
Publications
More detailed information about this field from each metasource.
An integrative approach to ortholog prediction for disease-focused and other functional studies
PMID: 21880147
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
A Drosophila resource of transgenic RNAi lines for neurogenetics
PMID: 19487563
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster
PMID: 18084299
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
Genomic screening with RNAi: results and challenges
PMID: 20367032
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays
PMID: 16964256
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
Design and implementation of high-throughput RNAi screens in cultured Drosophila cells
PMID: 17853882
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
FlyRNAi: the Drosophila RNAi screening center database
PMID: 16381918
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update
PMID: 22067456
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:45.497298
False negative rates in Drosophila cell-based RNAi screens: a case study
PMID: 21251254
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
Cross-species RNAi rescue platform in Drosophila melanogaster
PMID: 19720858
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
https://doi.org/10.1093/nar/gkaa936
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
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An integrative approach to ortholog prediction for disease-focused and other functional studies
PubMed citations: 312.
312 articles citing: An integrative approach to ortholog prediction for disease-focused and other functional studies
Ortholog genes from cactophilic Drosophila provide insight into human adaptation to hallucinogenic cacti. PMID:35915153
Strongly Truncated Dnaaf4 Plays a Conserved Role in Drosophila Ciliary Dynein Assembly as Part of an R2TP-Like Co-Chaperone Complex With Dnaaf6. PMID:35873488
A Drosophila melanogaster model for TMEM43-related arrhythmogenic right ventricular cardiomyopathy type 5. PMID:35869176
The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression. PMID:35796533
The evolution of vitamin C biosynthesis and transport in animals. PMID:35752765
Functional Studies of Genetic Variants Associated with Human Diseases in Notch Signaling-Related Genes Using Drosophila. PMID:35674905
Assessing the Roles of Potential Notch Signaling Components in Instructive and Permissive Pathways with Two Drosophila Pericardial Reporters. PMID:35674896
GRNbenchmark - a web server for benchmarking directed gene regulatory network inference methods. PMID:35609981
The Quest for Orthologs orthology benchmark service in 2022. PMID:35552456
Concurrent outcomes from multiple approaches of epistasis analysis for human body mass index associated loci provide insights into obesity biology. PMID:35508500
The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy. PMID:35501350
Trans-omics analysis of insulin action reveals a cell growth subnetwork which co-regulates anabolic processes. PMID:35494245
Coexpression reveals conserved gene programs that co-vary with cell type across kingdoms. PMID:35451481
A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. PMID:35413237
Disease Modeling of Rare Neurological Disorders in Zebrafish. PMID:35409306
Predicted mouse interactome and network-based interpretation of differentially expressed genes. PMID:35390003
Harmonizing model organism data in the Alliance of Genome Resources. PMID:35380658
JaponicusDB: rapid deployment of a model organism database for an emerging model species. PMID:35380656
Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. PMID:35301315
Drosophila functional screening of de novo variants in autism uncovers damaging variants and facilitates discovery of rare neurodevelopmental diseases. PMID:35294868
Inter-Species Rescue of Mutant Phenotype-The Standard for Genetic Analysis of Human Genetic Disorders in Drosophila melanogaster Model. PMID:35269756
FlyBase: a guided tour of highlighted features. PMID:35266522
Using Drosophila Nephrocytes to Understand the Formation and Maintenance of the Podocyte Slit Diaphragm. PMID:35265622
Invertebrate Model Organisms as a Platform to Investigate Rare Human Neurological Diseases. PMID:35256540
Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures. PMID:35240055
Genetics and Brain Transcriptomics of Completed Suicide. PMID:35236118
ModelMatcher: A scientist-centric online platform to facilitate collaborations between stakeholders of rare and undiagnosed disease research. PMID:35224820
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. PMID:35177854
Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. PMID:35148841
WormBase in 2022-data, processes, and tools for analyzing Caenorhabditis elegans. PMID:35134929
Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling. PMID:35044823
SLC22 Transporters in the Fly Renal System Regulate Response to Oxidative Stress In Vivo. PMID:34948211
Temporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability. PMID:34943911
A cis-regulatory-directed pipeline for the identification of genes involved in cardiac development and disease. PMID:34906219
New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources. PMID:34897464
Drosophila Trachea as a Novel Model of COPD. PMID:34884534
Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia. PMID:34878094
Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators. PMID:34853303
A Drosophila RNAi screen reveals conserved glioblastoma-related adhesion genes that regulate collective cell migration. PMID:34849760
Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos. PMID:34819517
Echinobase: leveraging an extant model organism database to build a knowledgebase supporting research on the genomics and biology of echinoderms. PMID:34791383
A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila. PMID:34780463
Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen. PMID:34779571
Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila. PMID:34748544
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients. PMID:34746695
Loxl2 is a mediator of cardiac aging in Drosophila melanogaster, genetically examining the role of aging clock genes. PMID:34734976
Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. PMID:34725363
ConVarT: a search engine for matching human genetic variants with variants from non-human species. PMID:34718716
Mouse Genome Informatics (MGI): latest news from MGD and GXD. PMID:34698891
The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization. PMID:34556579
Circadian regulation of the Drosophila astrocyte transcriptome. PMID:34543266
Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation. PMID:34529939
A scalable Drosophila assay for clinical interpretation of human PTEN variants in suppression of PI3K/AKT induced cellular proliferation. PMID:34492006
Phosphatidylserine synthase plays an essential role in glia and affects development, as well as the maintenance of neuronal function. PMID:34401677
Tumour-host interactions through the lens of Drosophila. PMID:34389815
A nomenclature for echinoderm genes. PMID:34386815
Identification of conserved transcriptome features between humans and Drosophila in the aging brain utilizing machine learning on combined data from the NIH Sequence Read Archive. PMID:34379632
TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila. PMID:34314705
Modelling of BCS1L-related human mitochondrial disease in Drosophila melanogaster. PMID:34274978
Transcriptome analysis of chloride intracellular channel knockdown in Drosophila identifies oxidation-reduction function as possible mechanism of altered sensitivity to ethanol sedation. PMID:34228751
Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11. PMID:34113007
RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. PMID:34096503
The foraging gene affects alcohol sensitivity, metabolism and memory in Drosophila. PMID:34092172
Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster. PMID:34074789
Alcohol-induced aggression in Drosophila. PMID:34044470
The epigenetic regulator G9a attenuates stress-induced resistance and metabolic transcriptional programs across different stressors and species. PMID:34030685
Integration of 1:1 orthology maps and updated datasets into Echinobase. PMID:34010390
DRscDB: A single-cell RNA-seq resource for data mining and data comparison across species. PMID:33995899
Functional conservation in genes and pathways linking ageing and immunity. PMID:33990202
Model organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision. PMID:33962631
Updates to HCOP: the HGNC comparison of orthology predictions tool. PMID:33959747
Proteomics of protein trafficking by in vivo tissue-specific labeling. PMID:33888706
Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis. PMID:33871358
Receptors and Channels Associated with Alcohol Use: Contributions from Drosophila. PMID:33870197
Rare deleterious de novo missense variants in Rnf2/Ring2 are associated with a neurodevelopmental disorder with unique clinical features. PMID:33864376
Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis. PMID:33819264
Cellular Control of Protein Turnover via the Modification of the Amino Terminus. PMID:33805528
Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection. PMID:33789347
TDP-43 and PINK1 mediate CHCHD10S59L mutation-induced defects in Drosophila and in vitro. PMID:33772006
Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatment. PMID:33766136
TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6. PMID:33762006
Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila. PMID:33735180
HIR V2: a human interactome resource for the biological interpretation of differentially expressed genes via gene set linkage analysis. PMID:33677507
Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age. PMID:33667157
Stable Isotope Labeling of Amino Acids in Flies (SILAF) Reveals Differential Phosphorylation of Mitochondrial Proteins Upon Loss of OXPHOS Subunits. PMID:33640490
Exocyst-mediated membrane trafficking of the lissencephaly-associated ECM receptor dystroglycan is required for proper brain compartmentalization. PMID:33620318
Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin. PMID:33618800
The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters. PMID:33608280
The chromatin remodeler ISWI acts during Drosophila development to regulate adult sleep. PMID:33597246
Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. PMID:33591981
Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. PMID:33576571
The extracellular matrix phenome across species. PMID:33543035
In-silico definition of the Drosophila melanogaster matrisome. PMID:33543012
SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. PMID:33527896
Prediction of complex phenotypes using the Drosophila melanogaster metabolome. PMID:33510469
Slowed Protein Turnover in Aging Drosophila Reflects a Shift in Cellular Priorities. PMID:33453098
Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. PMID:33319750
Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model. PMID:33318181
Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy. PMID:33311497
Identification of Genes Contributing to a Long Circadian Period in Drosophila Melanogaster. PMID:33274675
In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. PMID:33274328
An Automated Functional Annotation Pipeline That Rapidly Prioritizes Clinically Relevant Genes for Autism Spectrum Disorder. PMID:33261099
BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. PMID:33232675
FlyBase: updates to the Drosophila melanogaster knowledge base. PMID:33219682
Predicted rat interactome database and gene set linkage analysis. PMID:33216897
Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila. PMID:33116184
FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2021 update. PMID:33104800
Predicted functional interactome of Caenorhabditis elegans and a web tool for the functional interpretation of differentially expressed genes. PMID:33076954
The Drosophila seminal proteome and its role in postcopulatory sexual selection. PMID:33070726
Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans. PMID:33066036
Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart. PMID:33033063
BioLitMine: Advanced Mining of Biomedical and Biological Literature About Human Genes and Genes from Major Model Organisms. PMID:33028629
Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome. PMID:33006316
Integrated analysis of the aging brain transcriptome and proteome in tauopathy. PMID:32993812
Dynamics of a Protein Interaction Network Associated to the Aggregation of polyQ-Expanded Ataxin-1. PMID:32992839
SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol. PMID:32957927
Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease. PMID:32878640
Drosophila and its gut microbes: a model for drug-microbiome interactions. PMID:32855644
Predictive features of gene expression variation reveal mechanistic link with differential expression. PMID:32767663
miR-92a Suppresses Mushroom Body-Dependent Memory Consolidation in Drosophila. PMID:32737186
Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila. PMID:32644988
A Genetic Analysis of Tumor Progression in Drosophila Identifies the Cohesin Complex as a Suppressor of Individual and Collective Cell Invasion. PMID:32629605
Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development. PMID:32579612
Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling. PMID:32561720
Automated generation of gene summaries at the Alliance of Genome Resources. PMID:32559296
An Unbiased Drug Screen for Seizure Suppressors in Duplication 15q Syndrome Reveals 5-HT1A and Dopamine Pathway Activation as Potential Therapies. PMID:32507391
Frameshift mutations of YPEL3 alter the sensory circuit function in Drosophila. PMID:32461240
Intron and gene size expansion during nervous system evolution. PMID:32410625
The Quest for Orthologs benchmark service and consensus calls in 2020. PMID:32374845
Protein phosphatase 1 activity controls a balance between collective and single cell modes of migration. PMID:32369438
De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment. PMID:32356556
CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. PMID:32355295
Drosophila as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system. PMID:32345720
Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target. PMID:32345615
Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control. PMID:32339168
Variants in CAPZA2, a member of an F-actin capping complex, cause intellectual disability and developmental delay. PMID:32338762
De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy. PMID:32330417
Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells. PMID:32240602
A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation. PMID:32163402
Alcohol Causes Lasting Differential Transcription in Drosophila Mushroom Body Neurons. PMID:32132098
A Connected Network of Interacting Proteins Is Involved in Human-Tau Toxicity in Drosophila. PMID:32116515
The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells. PMID:32107390
Predicted Drosophila Interactome Resource and web tool for functional interpretation of differentially expressed genes. PMID:32103267
Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells. PMID:32102991
Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies. PMID:32071193
Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels. PMID:32054635
NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models. PMID:32053595
Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila. PMID:32049582
Genetic interaction screen for severe neurodevelopmental disorders reveals a functional link between Ube3a and Mef2 in Drosophila melanogaster. PMID:31988313
Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy. PMID:31959160
The DNA polymerases of Drosophila melanogaster. PMID:31933406
A cell atlas of the adult Drosophila midgut. PMID:31915294
Straightjacket/α2δ3 deregulation is associated with cardiac conduction defects in myotonic dystrophy type 1. PMID:31829940
Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction. PMID:31785787
Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET. PMID:31784520
Functional conservation of RecQ helicase BLM between humans and Drosophila melanogaster. PMID:31772289
A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease. PMID:31767637
Genetic architecture of subcortical brain structures in 38,851 individuals. PMID:31636452
Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders. PMID:31616000
Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature. PMID:31607425
Next-Generation Genome-Scale Models Incorporating Multilevel 'Omics Data: From Yeast to Human. PMID:31602621
HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. PMID:31570513
Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion. PMID:31566424
Alliance of Genome Resources Portal: unified model organism research platform. PMID:31552413
Using MARRVEL v1.2 for Bioinformatics Analysis of Human Genes and Variant Pathogenicity. PMID:31524990
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information. PMID:31475990
An RNAi Screen for Genes Required for Growth of Drosophila Wing Tissue. PMID:31387856
A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice. PMID:31365869
De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia. PMID:31327508
A Cyclin A-Myb-MuvB-Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles. PMID:31291240
Glial α-synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo. PMID:31267577
Convergent Evidence From Humans and Drosophila melanogaster Implicates the Transcription Factor MEF2B/Mef2 in Alcohol Sensitivity. PMID:31241765
Advances and Applications in the Quest for Orthologs. PMID:31241141
The Genomics of Arthrogryposis, a Complex Trait: Candidate Genes and Further Evidence for Oligogenic Inheritance. PMID:31230720
The fruit fly at the interface of diagnosis and pathogenic mechanisms of rare and common human diseases. PMID:31227826
Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules. PMID:31217461
Characterizing building blocks of resource constrained biological networks. PMID:31216986
CAPRI enables comparison of evolutionarily conserved RNA interacting regions. PMID:31213602
STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation. PMID:31167138
Direct role for the Drosophila GIGYF protein in 4EHP-mediated mRNA repression. PMID:31114929
A Comprehensive Drosophila melanogaster Transcription Factor Interactome. PMID:30995488
Rare variants in MYH15 modify amyotrophic lateral sclerosis risk. PMID:30985904
Expressional Profiling of Carpet Glia in the Developing Drosophila Eye Reveals Its Molecular Signature of Morphology Regulators. PMID:30983950
Enabling cell-type-specific behavioral epigenetics in Drosophila: a modified high-yield INTACT method reveals the impact of social environment on the epigenetic landscape in dopaminergic neurons. PMID:30967153
Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism. PMID:30902980
Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans. PMID:30873275
Increased intron retention is a post-transcriptional signature associated with progressive aging and Alzheimer's disease. PMID:30868713
Autophagy accounts for approximately one-third of mitochondrial protein turnover and is protein selective. PMID:30865561
Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. PMID:30774648
Ion Channel Contributions to Wing Development in Drosophila melanogaster. PMID:30733380
Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. PMID:30689844
RiboTag translatomic profiling of Drosophila oenocytes under aging and induced oxidative stress. PMID:30651069
Assigning confidence scores to homoeologs using fuzzy logic. PMID:30648004
Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis. PMID:30594291
Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders. PMID:30537354
Variants in PUS7 Cause Intellectual Disability with Speech Delay, Microcephaly, Short Stature, and Aggressive Behavior. PMID:30526862
As time flies by: Investigating cardiac aging in the short-lived Drosophila model. PMID:30496794
Quantifying Tissue-Specific Overexpression of FOXO in Drosophila via mRNA Fluorescence In Situ Hybridization Using Branched DNA Probe Technology. PMID:30414154
Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals. PMID:30404917
iProteinDB: An Integrative Database of Drosophila Post-translational Modifications. PMID:30397019
FlyBase 2.0: the next generation. PMID:30364959
Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster. PMID:30341464
The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death. PMID:30318245
Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles. PMID:30256786
The CCHamide1 Neuropeptide Expressed in the Anterior Dorsal Neuron 1 Conveys a Circadian Signal to the Ventral Lateral Neurons in Drosophila melanogaster. PMID:30246807
Model organism data evolving in support of translational medicine. PMID:30224793
Dme-Hsa Disease Database (DHDD): Conserved Human Disease-Related miRNA and Their Targeting Genes in Drosophila melanogaster. PMID:30200613
Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals. PMID:30147999
OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. PMID:30120140
Conservation of kinase-phosphorylation site pairings: Evidence for an evolutionarily dynamic phosphoproteome. PMID:30106995
Genes Involved in Drosophila melanogaster Ovarian Function Are Highly Conserved Throughout Evolution. PMID:30060195
IRF2BPL Is Associated with Neurological Phenotypes. PMID:30057031
Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells. PMID:30051818
Microfluidics for mechanobiology of model organisms. PMID:30037463
ProMotE: an efficient algorithm for counting independent motifs in uncertain network topologies. PMID:29940838
Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function. PMID:29924997
A Cyclin E Centered Genetic Network Contributes to Alcohol-Induced Variation in Drosophila Development. PMID:29871898
Using Drosophila to study mechanisms of hereditary hearing loss. PMID:29853544
Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation. PMID:29792348
Using FlyBase to Find Functionally Related Drosophila Genes. PMID:29761468
A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses. PMID:29608557
Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models. PMID:29598827
A gene-specific T2A-GAL4 library for Drosophila. PMID:29565247
Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function. PMID:29343513
The von Hippel-Lindau Gene Is Required to Maintain Renal Proximal Tubule and Glomerulus Integrity in Zebrafish Larvae. PMID:29342457
The ABC Transporter Eato Promotes Cell Clearance in the Drosophila melanogaster Ovary. PMID:29295819
The ModERN Resource: Genome-Wide Binding Profiles for Hundreds of Drosophila and Caenorhabditis elegans Transcription Factors. PMID:29284660
Genotype Influences Day-to-Day Variability in Sleep in Drosophila melanogaster. PMID:29228366
Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster Cultured Cells. PMID:29223976
Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA). PMID:29183982
Molecular Interaction Search Tool (MIST): an integrated resource for mining gene and protein interaction data. PMID:29155944
Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture. PMID:29078798
The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. PMID:28965825
Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo. PMID:28963550
Identification of genetic networks that act in the somatic cells of the testis to mediate the developmental program of spermatogenesis. PMID:28957323
A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade. PMID:28825401
Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl. PMID:28760809
Regulation of Mitochondrial Complex I Biogenesis in Drosophila Flight Muscles. PMID:28683319
Gene2Function: An Integrated Online Resource for Gene Function Discovery. PMID:28663344
Genetics of alcohol consumption in Drosophila melanogaster. PMID:28627812
Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species. PMID:28581519
Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells. PMID:28575377
Multifunctional glial support by Semper cells in the Drosophila retina. PMID:28562601
Genomic Analysis of Genotype-by-Social Environment Interaction for Drosophila melanogaster Aggressive Behavior. PMID:28550016
Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes. PMID:28512194
MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome. PMID:28502612
A Personalized Model of COQ2 Nephropathy Rescued by the Wild-Type COQ2 Allele or Dietary Coenzyme Q10 Supplementation. PMID:28428331
Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS. PMID:28301478
Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging. PMID:28221375
The Drosophila Gene Expression Tool (DGET) for expression analyses. PMID:28187709
A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome. PMID:28164240
Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits. PMID:28151408
Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. PMID:28137300
Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways. PMID:28131822
High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila. PMID:28084990
miR-263a Regulates ENaC to Maintain Osmotic and Intestinal Stem Cell Homeostasis in Drosophila. PMID:28017617
Modeling Monogenic Human Nephrotic Syndrome in the Drosophila Garland Cell Nephrocyte. PMID:27932481
Exploring FlyBase Data Using QuickSearch. PMID:27930807
FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2017 update. PMID:27924039
WORMHOLE: Novel Least Diverged Ortholog Prediction through Machine Learning. PMID:27812085
Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila. PMID:27809764
FlyBase at 25: looking to the future. PMID:27799470
Using FlyBase, a Database of Drosophila Genes and Genomes. PMID:27730573
RhoA GTPase inhibition organizes contraction during epithelial morphogenesis. PMID:27551058
The translation factors of Drosophila melanogaster. PMID:27494710
Comparative transcriptomic analysis of human and Drosophila extracellular vesicles. PMID:27282340
Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease. PMID:27185879
Identification of Novel Regulators of the JAK/STAT Signaling Pathway that Control Border Cell Migration in the Drosophila Ovary. PMID:27175018
A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes. PMID:27129311
Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. PMID:27113998
Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets. PMID:27091990
MECP2 impairs neuronal structure by regulating KIBRA. PMID:27015692
Testing candidate genes for attention-deficit/hyperactivity disorder in fruit flies using a high throughput assay for complex behavior. PMID:26954609
Modeling congenital disease and inborn errors of development in Drosophila melanogaster. PMID:26935104
FlyBase portals to human disease research using Drosophila models. PMID:26935103
The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster. PMID:26859824
Zfrp8 forms a complex with fragile-X mental retardation protein and regulates its localization and function. PMID:26772998
Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster. PMID:26751788
Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen. PMID:26643480
Insights into ALS pathomechanisms: from flies to humans. PMID:26594942
Conserved piRNA Expression from a Distinct Set of piRNA Cluster Loci in Eutherian Mammals. PMID:26588211
Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila. PMID:26567182
An Orthologous Epigenetic Gene Expression Signature Derived from Differentiating Embryonic Stem Cells Identifies Regulators of Cardiogenesis. PMID:26485529
Vilya, a component of the recombination nodule, is required for meiotic double-strand break formation in Drosophila. PMID:26452093
Quantitative analysis of the murine lipid droplet-associated proteome during diet-induced hepatic steatosis. PMID:26416795
Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase. PMID:26362788
The Transgenic RNAi Project at Harvard Medical School: Resources and Validation. PMID:26320097
PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications. PMID:26283093
Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder. PMID:26173477
Beyond antioxidant genes in the ancient Nrf2 regulatory network. PMID:26163000
GLAD: an Online Database of Gene List Annotation for Drosophila. PMID:26157507
Network analyses reveal novel aspects of ALS pathogenesis. PMID:25826266
Drosophila and experimental neurology in the post-genomic era. PMID:25814441
Enhancer modeling uncovers transcriptional signatures of individual cardiac cell states in Drosophila. PMID:25609699
EHFPI: a database and analysis resource of essential host factors for pathogenic infection. PMID:25414353
Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in Drosophila. PMID:25409104
A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis. PMID:25361581
Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos. PMID:25284370
Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. PMID:24912190
Resources for functional genomics studies in Drosophila melanogaster. PMID:24653003
Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. PMID:24067533
Conserved regulators of nucleolar size revealed by global phenotypic analyses. PMID:23962978
Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders. PMID:23954164
FlyPrimerBank: an online database for Drosophila melanogaster gene expression analysis and knockdown evaluation of RNAi reagents. PMID:23893746
UP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents. PMID:23792952
Genetic determinants of phosphate response in Drosophila. PMID:23520455
Protein complex-based analysis framework for high-throughput data sets. PMID:23443684
A genetic basis for the variable effect of smoking/nicotine on Parkinson's disease. PMID:23032990
Neurological disorders: towards a mechanistic understanding of restless legs syndrome. PMID:22720681
Mouse genetic and phenotypic resources for human genetics. PMID:22422677
FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update. PMID:22067456
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. PMID:22028469 -
A Drosophila resource of transgenic RNAi lines for neurogenetics
PubMed citations: 177.
177 articles citing: A Drosophila resource of transgenic RNAi lines for neurogenetics
Septins tune lipid kinase activity and PI(4,5)P2 turnover during G-protein-coupled PLC signalling in vivo. PMID:35277468
A LexAop > UAS > QUAS trimeric plasmid to generate inducible and interconvertible Drosophila overexpression transgenes. PMID:35264662
Transcriptomic and Genetic Analyses Identify the Krüppel-Like Factor Dar1 as a New Regulator of Tube-Shaped Long Tendon Development. PMID:34977007
Conditional CRISPR-Cas Genome Editing in Drosophila to Generate Intestinal Tumors. PMID:34831379
Male-biased protein expression in primordial germ cells, identified through a comparative study of UAS vectors in Drosophila. PMID:34728669
Repression precedes independent evolutionary gains of a highly specific gene expression pattern. PMID:34706247
Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction. PMID:34398892
A neuronal ensemble encoding adaptive choice during sensory conflict in Drosophila. PMID:34226544
Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling. PMID:33893307
A KDM5-Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation. PMID:33729157
Characterizing the genetic basis of copper toxicity in Drosophila reveals a complex pattern of allelic, regulatory, and behavioral variation. PMID:33683361
pNP Transgenic RNAi System Manual in Drosophila. PMID:33654966
Homeodomain protein Six4 prevents the generation of supernumerary Drosophila type II neuroblasts and premature differentiation of intermediate neural progenitors. PMID:33556050
Sex and Death: Identification of Feedback Neuromodulation Balancing Reproduction and Survival. PMID:33174166
Enhanced Efficiency of flySAM by Optimization of sgRNA Parameters in Drosophila. PMID:33020192
A Nucleolar Isoform of the Drosophila Ubiquitin Specific Protease dUSP36 Regulates MYC-Dependent Cell Growth. PMID:32637412
An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila. PMID:32592682
Programmable RNA Targeting Using CasRx in Flies. PMID:32584145
Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons. PMID:32314964
Anchor Away - A Fast, Reliable and Reversible Technique To Inhibit Proteins in Drosophila melanogaster. PMID:32217630
Identification of a molecular basis for the juvenile sleep state. PMID:32202500
A novel transcriptional cascade is involved in Fzr-mediated endoreplication. PMID:32182338
Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies. PMID:32071193
A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila. PMID:32053108
PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation. PMID:31877058
A neural mechanism for deprivation state-specific expression of relevant memories in Drosophila. PMID:31659341
Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila. PMID:31628317
The Egalitarian binding partners Dynein light chain and Bicaudal-D act sequentially to link mRNA to the Dynein motor. PMID:31391195
Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila. PMID:31251895
Maintenance of homeostatic plasticity at the Drosophila neuromuscular synapse requires continuous IP3-directed signaling. PMID:31180325
Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila. PMID:31071084
The impact of Megf10/Drpr gain-of-function on muscle development in Drosophila. PMID:30802937
Activity-Dependent Remodeling of Drosophila Olfactory Sensory Neuron Brain Innervation during an Early-Life Critical Period. PMID:30755492
Daily Regulation of Phototransduction, Circadian Clock, DNA Repair, and Immune Gene Expression by Heme Oxygenase in the Retina of Drosophila. PMID:30583479
An in vivo screen for neuronal genes involved in obesity identifies Diacylglycerol kinase as a regulator of insulin secretion. PMID:30389349
An efficient and multiple target transgenic RNAi technique with low toxicity in Drosophila. PMID:30297884
Ade2 Functions in the Drosophila Fat Body To Promote Sleep. PMID:30249751
The Drosophila Small Conductance Calcium-Activated Potassium Channel Negatively Regulates Nociception. PMID:30231996
In vivo expansion of functionally integrated GABAergic interneurons by targeted increase in neural progenitors. PMID:29728368
Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline in Drosophila. PMID:29669801
Efficient Expression of Genes in the Drosophila Germline Using a UAS Promoter Free of Interference by Hsp70 piRNAs. PMID:29669732
Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM. PMID:29666231
Requirement of the Dynein-Adaptor Spindly for Mitotic and Post-Mitotic Functions in Drosophila. PMID:29615558
Identification of Proteins Required for Precise Positioning of Apc2 in Dendrites. PMID:29602811
A gene-specific T2A-GAL4 library for Drosophila. PMID:29565247
Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior. PMID:29547121
Drosophila Full-Length Amyloid Precursor Protein Is Required for Visual Working Memory and Prevents Age-Related Memory Impairment. PMID:29478851
Copper and Zinc Homeostasis: Lessons from Drosophila melanogaster. PMID:29312444
Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. PMID:29276004
Dopamine Receptor DAMB Signals via Gq to Mediate Forgetting in Drosophila. PMID:29166600
Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains. PMID:29155751
Artificial selection for odor-guided behavior in Drosophila reveals changes in food consumption. PMID:29132294
Molecular mechanisms of developmentally programmed crinophagy in Drosophila. PMID:29066608
Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion. PMID:28986465
Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment. PMID:28585544
Specification and spatial arrangement of cells in the germline stem cell niche of the Drosophila ovary depend on the Maf transcription factor Traffic jam. PMID:28542174
Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila. PMID:28406902
SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression. PMID:28331058
Amyloid Precursor Protein in Drosophila Glia Regulates Sleep and Genes Involved in Glutamate Recycling. PMID:28314820
Measuring and Altering Mating Drive in Male Drosophila melanogaster. PMID:28287580
FlpStop, a tool for conditional gene control in Drosophila. PMID:28211790
Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics. PMID:27588305
A simple method for imaging axonal transport in aging neurons using the adult Drosophila wing. PMID:27560175
Potential Direct Regulators of the Drosophila yellow Gene Identified by Yeast One-Hybrid and RNAi Screens. PMID:27527791
Interactions Between the Circadian Clock and Heme Oxygenase in the Retina of Drosophila melanogaster. PMID:27520276
Selective endosomal microautophagy is starvation-inducible in Drosophila. PMID:27487474
Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila. PMID:27484291
Wallenda/DLK protein levels are temporally downregulated by Tramtrack69 to allow R7 growth cones to become stationary boutons. PMID:27402706
Nociceptor-Enriched Genes Required for Normal Thermal Nociception. PMID:27346357
The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals. PMID:27331610
Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination. PMID:27195754
Different cell cycle modifications repress apoptosis at different steps independent of developmental signaling in Drosophila. PMID:27075174
Apontic regulates somatic stem cell numbers in Drosophila testes. PMID:26993259
Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster. PMID:26975047
Memory-Relevant Mushroom Body Output Synapses Are Cholinergic. PMID:26948892
The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184. PMID:26906422
The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. PMID:26896569
Neuronal processing of noxious thermal stimuli mediated by dendritic Ca(2+) influx in Drosophila somatosensory neurons. PMID:26880554
ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. PMID:26813350
The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testis. PMID:26792023
The Drosophila Helicase MLE Targets Hairpin Structures in Genomic Transcripts. PMID:26752049
The Nuclear Matrix Protein Megator Regulates Stem Cell Asymmetric Division through the Mitotic Checkpoint Complex in Drosophila Testes. PMID:26714316
Nitric oxide mediates glial-induced neurodegeneration in Alexander disease. PMID:26608817
Curly Encodes Dual Oxidase, Which Acts with Heme Peroxidase Curly Su to Shape the Adult Drosophila Wing. PMID:26587980
Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing. PMID:26510564
Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery. PMID:26494711
Trithorax regulates systemic signaling during Drosophila imaginal disc regeneration. PMID:26487779
Regulation of dendrite growth and maintenance by exocytosis. PMID:26483382
Genome engineering: Drosophila melanogaster and beyond. PMID:26447401
Re-Classification of Drosophila melanogaster Trichoid and Intermediate Sensilla Using Fluorescence-Guided Single Sensillum Recording. PMID:26431203
Tricornered Kinase Regulates Synapse Development by Regulating the Levels of Wiskott-Aldrich Syndrome Protein. PMID:26393506
Identified Serotonin-Releasing Neurons Induce Behavioral Quiescence and Suppress Mating in Drosophila. PMID:26377467
The Transgenic RNAi Project at Harvard Medical School: Resources and Validation. PMID:26320097
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. PMID:26308891
The iBeetle large-scale RNAi screen reveals gene functions for insect development and physiology. PMID:26215380
A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs. PMID:26081261
Genetic Tools for the Analysis of Drosophila Stomatogastric Nervous System Development. PMID:26053861
The systematic identification of cytoskeletal genes required for Drosophila melanogaster muscle maintenance. PMID:25977760
ADHD-associated dopamine transporter, latrophilin and neurofibromin share a dopamine-related locomotor signature in Drosophila. PMID:25962619
A single-cross, RNA interference-based genetic tool for examining the long-term maintenance of homeostatic plasticity. PMID:25859184
Metabolic learning and memory formation by the brain influence systemic metabolic homeostasis. PMID:25848677
The drosophila T-box transcription factor midline functions within Insulin/Akt and c-Jun-N terminal kinase stress-reactive signaling pathways to regulate interommatial bristle formation and cell survival. PMID:25748605
Generating customized transgene landing sites and multi-transgene arrays in Drosophila using phiC31 integrase. PMID:25680812
The Hippo pathway regulates homeostatic growth of stem cell niche precursors in the Drosophila ovary. PMID:25643260
RhoGAP68F controls transport of adhesion proteins in Rab4 endosomes to modulate epithelial morphogenesis of Drosophila leg discs. PMID:25617722
Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila. PMID:25398939
Differential centrifugation-based biochemical fractionation of the Drosophila adult CNS. PMID:25393777
Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. PMID:25294943
CRISPR/Cas9 mediates efficient conditional mutagenesis in Drosophila. PMID:25193494
Leigh syndrome in Drosophila melanogaster: morphological and biochemical characterization of Surf1 post-transcriptional silencing. PMID:25164807
E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila. PMID:25015288
Spermatid cyst polarization in Drosophila depends upon apkc and the CPEB family translational regulator orb2. PMID:24830287
A presynaptic role of microtubule-associated protein 1/Futsch in Drosophila: regulation of active zone number and neurotransmitter release. PMID:24828631
The Little Fly that Could: Wizardry and Artistry of Drosophila Genomics. PMID:24827974
Generation of transgenic Drosophila expressing shRNAs in the miR-1 backbone. PMID:24786506
The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PMID:24781186
The homeodomain protein ladybird late regulates synthesis of milk proteins during pregnancy in the tsetse fly (Glossina morsitans). PMID:24763082
Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary. PMID:24658126
Genetic odyssey to generate marked clones in Drosophila mosaics. PMID:24623854
Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster. PMID:24583113
A regulatory network of Drosophila germline stem cell self-renewal. PMID:24576427
The ALS gene FUS regulates synaptic transmission at the Drosophila neuromuscular junction. PMID:24569165
dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling. PMID:24553921
Functional characterization of drim2, the Drosophila melanogaster homolog of the yeast mitochondrial deoxynucleotide transporter. PMID:24469456
Cell-type-specific labeling of synapses in vivo through synaptic tagging with recombination. PMID:24462095
Evolutionary rate covariation identifies new members of a protein network required for Drosophila melanogaster female post-mating responses. PMID:24453993
Methods for studying oogenesis. PMID:24440745
An unexpected link between notch signaling and ROS in restricting the differentiation of hematopoietic progenitors in Drosophila. PMID:24318532
Spatio-temporal requirements for transposable element piRNA-mediated silencing during Drosophila oogenesis. PMID:24288375
New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system. PMID:24198346
Efficient site-specific transgenesis and enhancer activity tests in medaka using PhiC31 integrase. PMID:24048591
The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine. PMID:23942514
FlyPrimerBank: an online database for Drosophila melanogaster gene expression analysis and knockdown evaluation of RNAi reagents. PMID:23893746
Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding. PMID:23878279
UP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents. PMID:23792952
Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system. PMID:23723152
The circadian clock gates the intestinal stem cell regenerative state. PMID:23583176
Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases. PMID:23525903
The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. PMID:23509070
Inhibition of diuretic stimulation of an insect secretory epithelium by a cGMP-dependent protein kinase. PMID:23445619
The homeobox transcription factor cut coordinates patterning and growth during Drosophila airway remodeling. PMID:23423438
Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo. PMID:23363604
Down-regulation of Decapping Protein 2 mediates chronic nicotine exposure-induced locomotor hyperactivity in Drosophila. PMID:23300696
On the role of PDZ domain-encoding genes in Drosophila border cell migration. PMID:23173089
The genetic analysis of functional connectomics in Drosophila. PMID:23084874
Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis. PMID:23048182
Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila. PMID:22952930
Two Drosophila DEG/ENaC channel subunits have distinct functions in gustatory neurons that activate male courtship. PMID:22915128
A modular toolset for recombination transgenesis and neurogenetic analysis of Drosophila. PMID:22848718
A genome-wide transgenic resource for conditional expression of Drosophila microRNAs. PMID:22745315
Reshaping of global gene expression networks and sex-biased gene expression by integration of a young gene. PMID:22543869
A Drosophila DEG/ENaC subunit functions specifically in gustatory neurons required for male courtship behavior. PMID:22457513
Analysis of glial cell development and function in Drosophila. PMID:22194269
Functional genome annotation of Drosophila seminal fluid proteins using transcriptional genetic networks. PMID:22189604
Asymmetric cell division and Notch signaling specify dopaminergic neurons in Drosophila. PMID:22073214
Automated protein-DNA interaction screening of Drosophila regulatory elements. PMID:22037703
Genetic manipulation of genes and cells in the nervous system of the fruit fly. PMID:22017985
An integrative approach to ortholog prediction for disease-focused and other functional studies. PMID:21880147
Yki/YAP, Sd/TEAD and Hth/MEIS control tissue specification in the Drosophila eye disc epithelium. PMID:21811580
Drosophila RNAi screening in a postgenomic world. PMID:21752787
Sequential phosphorylation of smoothened transduces graded hedgehog signaling. PMID:21730325
The actin nucleator WASp is required for myoblast fusion during adult Drosophila myogenesis. PMID:21558381
Drosophila as a model for antiviral immunity. PMID:21541000
A genome-scale shRNA resource for transgenic RNAi in Drosophila. PMID:21460824
The coding of temperature in the Drosophila brain. PMID:21335241
New tools for the analysis of glial cell biology in Drosophila. PMID:21305614
The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin. PMID:21217822
Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila. PMID:21197652
A new resource for characterizing X-linked genes in Drosophila melanogaster: systematic coverage and subdivision of the X chromosome with nested, Y-linked duplications. PMID:20876560
Drosophila as a model system to study autophagy. PMID:20798940
Refinement of tools for targeted gene expression in Drosophila. PMID:20697123
In vivo RNAi: today and tomorrow. PMID:20534712
Vectors and parameters that enhance the efficacy of RNAi-mediated gene disruption in transgenic Drosophila. PMID:20534445
100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future. PMID:20383202
New research resources at the Bloomington Drosophila Stock Center. PMID:20160480
In vivo RNAi rescue in Drosophila melanogaster with genomic transgenes from Drosophila pseudoobscura. PMID:20126626
Cross-species RNAi rescue platform in Drosophila melanogaster. PMID:19720858 -
Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster
PubMed citations: 154.
154 articles citing: Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster
The effectiveness of EGFR knockdown by RNAi lines varies depending on the tissue. PMID:35903780
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. PMID:35859173
A LexAop > UAS > QUAS trimeric plasmid to generate inducible and interconvertible Drosophila overexpression transgenes. PMID:35264662
Genetic Reduction of Mitochondria Complex I Subunits is Protective against Cisplatin-Induced Neurotoxicity in Drosophila. PMID:34893548
A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79. PMID:34849820
Conditional CRISPR-Cas Genome Editing in Drosophila to Generate Intestinal Tumors. PMID:34831379
CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1. PMID:34726688
A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary. PMID:34718559
Heritable shifts in redox metabolites during mitochondrial quiescence reprogramme progeny metabolism. PMID:34545253
The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster. PMID:34376687
An apocrine mechanism delivers a fully immunocompetent exocrine secretion. PMID:34354130
Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals. PMID:34019080
RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila. PMID:33983927
Daily rewiring of a neural circuit generates a predictive model of environmental light. PMID:33762336
pNP Transgenic RNAi System Manual in Drosophila. PMID:33654966
A functional genomics screen identifying blood cell development genes in Drosophila by undergraduates participating in a course-based research experience. PMID:33561251
Expression of Mst89B and CG31287 is Needed for Effective Sperm Storage and Egg Fertilization in Drosophila. PMID:33535499
Programmable RNA Targeting Using CasRx in Flies. PMID:32584145
NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways. PMID:32559195
TRiP stocks contain a previously uncharacterized loss-of-function sevenless allele. PMID:32550423
Premature termination codon readthrough in Drosophila varies in a developmental and tissue-specific manner. PMID:32444687
Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity. PMID:32160200
Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies. PMID:32071193
Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity. PMID:31183966
The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking. PMID:31142545
Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline. PMID:31092924
Generation and Characterization of Germline-Specific Autophagy and Mitochondrial Reactive Oxygen Species Reporters in Drosophila. PMID:31001531
A Multivariate Genome-Wide Association Study of Wing Shape in Drosophila melanogaster. PMID:30792267
Rapid depletion of ESCRT protein Vps4 underlies injury-induced autophagic impediment and Wallerian degeneration. PMID:30788439
Drosophila strain specific response to cisplatin neurotoxicity. PMID:30668272
Injury-induced cold sensitization in Drosophila larvae involves behavioral shifts that require the TRP channel Brv1. PMID:30586392
Cytokine exocytosis and JAK/STAT activation in the Drosophila ovary requires the vesicle trafficking regulator α-Snap. PMID:30404830
The role of the trithorax group TnaA isoforms in Hox gene expression, and in Drosophila late development. PMID:30372466
An efficient and multiple target transgenic RNAi technique with low toxicity in Drosophila. PMID:30297884
A zinc-finger fusion protein refines Gal4-defined neural circuits. PMID:30126464
A potential Rho GEF and Rac GAP for coupled Rac and Rho cycles during mesenchymal-to-epithelial-like transitions. PMID:30032715
Impact of Drosophila Models in the Study and Treatment of Friedreich's Ataxia. PMID:29986523
Identification of raw as a regulator of glial development. PMID:29813126
Characterization of a morphogenetic furrow specific Gal4 driver in the developing Drosophila eye. PMID:29702674
Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity. PMID:29671950
Efficient Expression of Genes in the Drosophila Germline Using a UAS Promoter Free of Interference by Hsp70 piRNAs. PMID:29669732
Artificial selection for odor-guided behavior in Drosophila reveals changes in food consumption. PMID:29132294
dOCRL maintains immune cell quiescence by regulating endosomal traffic. PMID:29028801
Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion. PMID:28986465
Histone locus regulation by the Drosophila dosage compensation adaptor protein CLAMP. PMID:28838946
In vivo imaging reveals mitophagy independence in the maintenance of axonal mitochondria during normal aging. PMID:28782874
Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila. PMID:28754889
Spatial pattern analysis of nuclear migration in remodelled muscles during Drosophila metamorphosis. PMID:28693471
RNAi-Based Techniques for the Analysis of Gene Function in Drosophila Germline Stem Cells. PMID:28674809
Development of an optimized synthetic Notch receptor as an in vivo cell-cell contact sensor. PMID:28490499
Co-chaperone Hsp70/Hsp90-organizing protein (Hop) is required for transposon silencing and Piwi-interacting RNA (piRNA) biogenesis. PMID:28193840
A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome. PMID:28164240
High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila. PMID:28084990
Polyglutamine length-dependent toxicity from α1ACT in Drosophila models of spinocerebellar ataxia type 6. PMID:27979829
Interorgan Communication Pathways in Physiology: Focus on Drosophila. PMID:27732790
Coordinated autoinhibition of F-BAR domain membrane binding and WASp activation by Nervous Wreck. PMID:27601635
Role of BMP receptor traffic in synaptic growth defects in an ALS model. PMID:27535427
Potential Direct Regulators of the Drosophila yellow Gene Identified by Yeast One-Hybrid and RNAi Screens. PMID:27527791
Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling. PMID:27378074
Components of the Engulfment Machinery Have Distinct Roles in Corpse Processing. PMID:27347682
Steroid Hormone Signaling Is Essential for Pheromone Production and Oenocyte Survival. PMID:27333054
Molecular mechanism and functional significance of acid generation in the Drosophila midgut. PMID:27250760
The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling. PMID:27223326
Apontic regulates somatic stem cell numbers in Drosophila testes. PMID:26993259
The interplay between intestinal bacteria and host metabolism in health and disease: lessons from Drosophila melanogaster. PMID:26935105
Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction. PMID:26824655
The Drosophila Helicase MLE Targets Hairpin Structures in Genomic Transcripts. PMID:26752049
TrpA1 Regulates Defecation of Food-Borne Pathogens under the Control of the Duox Pathway. PMID:26726767
An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster. PMID:26596648
Genetics on the Fly: A Primer on the Drosophila Model System. PMID:26564900
Genome engineering: Drosophila melanogaster and beyond. PMID:26447401
Groucho restricts rhomboid expression and couples EGFR activation with R8 selection during Drosophila photoreceptor differentiation. PMID:26417727
Polarization of the epithelial layer and apical localization of integrins are required for engulfment of apoptotic cells in the Drosophila ovary. PMID:26398951
Tricornered Kinase Regulates Synapse Development by Regulating the Levels of Wiskott-Aldrich Syndrome Protein. PMID:26393506
The Transgenic RNAi Project at Harvard Medical School: Resources and Validation. PMID:26320097
The receptor tyrosine kinase Pvr promotes tissue closure by coordinating corpse removal and epidermal zippering. PMID:26293306
Dynamics of Inductive ERK Signaling in the Drosophila Embryo. PMID:26096970
Plasma membrane overgrowth causes fibrotic collagen accumulation and immune activation in Drosophila adipocytes. PMID:26090908
The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster. PMID:26007638
A single-cross, RNA interference-based genetic tool for examining the long-term maintenance of homeostatic plasticity. PMID:25859184
Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs. PMID:25855067
The impact of host diet on Wolbachia titer in Drosophila. PMID:25826386
Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila. PMID:25624267
Calcium waves occur as Drosophila oocytes activate. PMID:25564670
Isoform-specific functions of Mud/NuMA mediate binucleation of Drosophila male accessory gland cells. PMID:25527079
FMAj: a tool for high content analysis of muscle dynamics in Drosophila metamorphosis. PMID:25521203
A new model to study sleep deprivation-induced seizure. PMID:25515102
The NuRD nucleosome remodelling complex and NHK-1 kinase are required for chromosome condensation in oocytes. PMID:25501812
Somatic insulin signaling regulates a germline starvation response in Drosophila egg chambers. PMID:25481758
Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA parameters in Drosophila. PMID:25437567
CRISPR/Cas9 mediates efficient conditional mutagenesis in Drosophila. PMID:25193494
BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior. PMID:25154396
Performance of the Cas9 nickase system in Drosophila melanogaster. PMID:25128437
E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila. PMID:25015288
Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila. PMID:24979807
Phagocytic ability declines with age in adult Drosophila hemocytes. PMID:24828474
Generation of transgenic Drosophila expressing shRNAs in the miR-1 backbone. PMID:24786506
miR-8 controls synapse structure by repression of the actin regulator enabled. PMID:24718988
Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary. PMID:24658126
Genetic odyssey to generate marked clones in Drosophila mosaics. PMID:24623854
RNAi screen in Drosophila larvae identifies histone deacetylase 3 as a positive regulator of the hsp70 heat shock gene expression during heat shock. PMID:24607507
Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster. PMID:24583113
Insight into insulin secretion from transcriptome and genetic analysis of insulin-producing cells of Drosophila. PMID:24558258
Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration. PMID:24493646
Evolutionary rate covariation identifies new members of a protein network required for Drosophila melanogaster female post-mating responses. PMID:24453993
An unexpected link between notch signaling and ROS in restricting the differentiation of hematopoietic progenitors in Drosophila. PMID:24318532
The elongin complex antagonizes the chromatin factor Corto for vein versus intervein cell identity in Drosophila wings. PMID:24204884
New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system. PMID:24198346
Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. PMID:24191015
Drosophila fatty acid taste signals through the PLC pathway in sugar-sensing neurons. PMID:24068941
Genetic modifier screens to identify components of a redox-regulated cell adhesion and migration pathway. PMID:23849867
A method for reversible drug delivery to internal tissues of Drosophila embryos. PMID:23846179
The million mutation project: a new approach to genetics in Caenorhabditis elegans. PMID:23800452
UP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents. PMID:23792952
Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases. PMID:23525903
Inhibition of diuretic stimulation of an insect secretory epithelium by a cGMP-dependent protein kinase. PMID:23445619
The homeobox transcription factor cut coordinates patterning and growth during Drosophila airway remodeling. PMID:23423438
Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutants. PMID:23238721
UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery. PMID:23141543
Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. PMID:23021220
The histone acetyltransferases CBP and Chameau integrate developmental and DNA replication programs in Drosophila ovarian follicle cells. PMID:22951641
Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model. PMID:22828940
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. PMID:22684109
Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. PMID:22498775
Modelling tauopathies in Drosophila: insights from the fruit fly. PMID:22254145
Analysis of glial cell development and function in Drosophila. PMID:22194269
A screen for X-linked mutations affecting Drosophila photoreceptor differentiation identifies Casein kinase 1α as an essential negative regulator of wingless signaling. PMID:22095083
Asymmetric cell division and Notch signaling specify dopaminergic neurons in Drosophila. PMID:22073214
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. PMID:22028469
Genetic manipulation of genes and cells in the nervous system of the fruit fly. PMID:22017985
Hedgehog signaling regulates nociceptive sensitization. PMID:21906949
Drosophila RNAi screening in a postgenomic world. PMID:21752787
Successive and targeted DNA integrations in the Drosophila genome by Bxb1 and phiC31 integrases. PMID:21652525
The actin nucleator WASp is required for myoblast fusion during adult Drosophila myogenesis. PMID:21558381
A genome-scale shRNA resource for transgenic RNAi in Drosophila. PMID:21460824
Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. PMID:21295279
Sarcomere formation occurs by the assembly of multiple latent protein complexes. PMID:21124995
Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. PMID:20857302
Effects of small Hsp genes on developmental stability and microenvironmental canalization. PMID:20846409
Drosophila as a model system to study autophagy. PMID:20798940
Refinement of tools for targeted gene expression in Drosophila. PMID:20697123
Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release. PMID:20678575
Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling. PMID:20585550
In vivo RNAi: today and tomorrow. PMID:20534712
Molecular genetic analysis of Chd3 and polytene chromosome region 76B-D in Drosophila melanogaster. PMID:20439780
DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization. PMID:20392941
Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60. PMID:19949809
Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. PMID:19934041
A Drosophila resource of transgenic RNAi lines for neurogenetics. PMID:19487563
Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster. PMID:19465919
Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. PMID:19211682
A simplified miRNA-based gene silencing method for Drosophila melanogaster. PMID:18598689
RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. PMID:18359903
A Caenorhabditis elegans genetic-interaction map wiggles into view. PMID:18341704 -
Genomic screening with RNAi: results and challenges
PubMed citations: 140.
140 articles citing: Genomic screening with RNAi: results and challenges
Probenecid Inhibits Respiratory Syncytial Virus (RSV) Replication. PMID:35632652
Functional genomics and the future of iPSCs in disease modeling. PMID:35487213
An E3 Ubiquitin Ligase Scaffolding Protein Is Proviral during Chikungunya Virus Infection in Aedes aegypti. PMID:35435754
RNA Interference (RNAi) Screening in Cultured Drosophila Cells. PMID:34590272
A new era in functional genomics screens. PMID:34545248
Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy. PMID:34544865
Imaging of In Vitro and In Vivo Neurons in Drosophila Using Stochastic Optical Reconstruction Microscopy. PMID:34289261
Exploring liver cancer biology through functional genetic screens. PMID:34163045
Single-cell image analysis to explore cell-to-cell heterogeneity in isogenic populations. PMID:34139168
Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer's disease model. PMID:33536571
DGK and DZHK position paper on genome editing: basic science applications and future perspective. PMID:33449167
Comparative CRISPR type III-based knockdown of essential genes in hyperthermophilic Sulfolobales and the evasion of lethal gene silencing. PMID:32957821
TargetDB: A target information aggregation tool and tractability predictor. PMID:32877430
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality. PMID:32785687
Advances in high-throughput methods for the identification of virus receptors. PMID:31865406
Caenorhabditis elegans: a model to understand host-microbe interactions. PMID:31584128
Challenges of gene delivery to the central nervous system and the growing use of biomaterial vectors. PMID:31173859
Does co-transcriptional regulation of alternative splicing mediate plant stress responses? PMID:30793202
Generating and working with Drosophila cell cultures: Current challenges and opportunities. PMID:30561900
Mapping Cellular Reprogramming via Pooled Overexpression Screens with Paired Fitness and Single-Cell RNA-Sequencing Readout. PMID:30448000
RefCell: multi-dimensional analysis of image-based high-throughput screens based on 'typical cells'. PMID:30445906
Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection. PMID:30126372
Genome-wide siRNA screening in mouse bone marrow-derived macrophages revealed that knockdown of ribosomal proteins suppresses IL-10 and enhances TNF-α production. PMID:29657255
RNA Interference (RNAi) Screening in Drosophila. PMID:29487145
Target discovery screens using pooled shRNA libraries and next-generation sequencing: A model workflow and analytical algorithm. PMID:29385199
Identification of Rab18 as an Essential Host Factor for BK Polyomavirus Infection Using a Whole-Genome RNA Interference Screen. PMID:28815213
Using Docker Compose for the Simple Deployment of an Integrated Drug Target Screening Platform. PMID:28600904
Regulated Entry of Hepatitis C Virus into Hepatocytes. PMID:28486435
Defining functional interactions during biogenesis of epithelial junctions. PMID:27922008
Fluorescence Reporter-Based Genome-Wide RNA Interference Screening to Identify Alternative Splicing Regulators. PMID:27832528
Phenotypic MicroRNA Microarrays. PMID:27605181
Phenotypic screening with primary neurons to identify drug targets for regeneration and degeneration. PMID:27444126
Sources of Error in Mammalian Genetic Screens. PMID:27402361
Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia. PMID:27315426
Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine. PMID:27296290
RNA Interference in the Age of CRISPR: Will CRISPR Interfere with RNAi? PMID:26927085
An interactive web-based application for Comprehensive Analysis of RNAi-screen Data. PMID:26902267
High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation. PMID:26740620
A parallel genome-wide RNAi screening strategy to identify host proteins important for entry of Marburg virus and H5N1 influenza virus. PMID:26596270
The effects of natural selection across molecular pathways in Drosophila melanogaster. PMID:26391223
Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects. PMID:26197079
Dual silencing of Bcl-2 and Survivin by HSV-1 vector shows better antitumor efficacy in higher PKR phosphorylation tumor cells in vitro and in vivo. PMID:26138562
NEMix: single-cell nested effects models for probabilistic pathway stimulation. PMID:25879530
Cell-based screening: extracting meaning from complex data. PMID:25856492
An integrative approach for a network based meta-analysis of viral RNAi screens. PMID:25691914
Simultaneous analysis of large-scale RNAi screens for pathogen entry. PMID:25534632
Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening. PMID:25495526
Ter94/VCP is a novel component involved in BMP signaling. PMID:25469707
Single-cell and multivariate approaches in genetic perturbation screens. PMID:25446316
Large-scale identification of chemically induced mutations in Drosophila melanogaster. PMID:25258387
A CRISPR view of development. PMID:25184674
Molecular biology approaches in bioadhesion research. PMID:25161834
RNAi screening comes of age: improved techniques and complementary approaches. PMID:25145850
Seed sequence-matched controls reveal limitations of small interfering RNA knockdown in functional and structural studies of hepatitis C virus NS5A-MOBKL1B interaction. PMID:25031347
Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis. PMID:24934636
siPools: highly complex but accurately defined siRNA pools eliminate off-target effects. PMID:24875475
Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycle. PMID:24852294
Assembly and validation of versatile transcription activator-like effector libraries. PMID:24798576
Soaking RNAi in Bombyx mori BmN4-SID1 cells arrests cell cycle progression. PMID:24773378
Integrative framework for identification of key cell identity genes uncovers determinants of ES cell identity and homeostasis. PMID:24711389
In Vivo RNAi-Based Screens: Studies in Model Organisms. PMID:24705267
Systems-level analysis of innate immunity. PMID:24655298
Resources for functional genomics studies in Drosophila melanogaster. PMID:24653003
Luciferase reporter assay in Drosophila and mammalian tissue culture cells. PMID:24652620
RNAi screening in Drosophila cells and in vivo. PMID:24576618
siRNA Genome Screening Approaches to Therapeutic Drug Repositioning. PMID:24275945
High-throughput RNA interference screens integrative analysis: Towards a comprehensive understanding of the virus-host interplay. PMID:24175227
ScreenSifter: analysis and visualization of RNAi screening data. PMID:24088301
A genome-wide systematic analysis reveals different and predictive proliferation expression signatures of cancerous vs. non-cancerous cells. PMID:24068970
Limited agreement of independent RNAi screens for virus-required host genes owes more to false-negative than false-positive factors. PMID:24068911
A loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexity. PMID:23991227
FlyPrimerBank: an online database for Drosophila melanogaster gene expression analysis and knockdown evaluation of RNAi reagents. PMID:23893746
Transfection of infectious RNA and DNA/RNA layered vectors of semliki forest virus by the cell-penetrating peptide based reagent PepFect6. PMID:23861978
Systematic analysis of RNAi reports identifies dismal commonality at gene-level and reveals an unprecedented enrichment in pooled shRNA screens. PMID:23848309
Inferring signalling networks from images. PMID:23841886
Identifying proteins controlling key disease signaling pathways. PMID:23812988
Integrated network analyses for functional genomic studies in cancer. PMID:23811269
UP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents. PMID:23792952
Antiviral Stratagems Against HIV-1 Using RNA Interference (RNAi) Technology. PMID:23761954
Production of cloned pigs with targeted attenuation of gene expression. PMID:23737990
Genome-wide RNAi screen reveals a role for the ESCRT complex in rotavirus cell entry. PMID:23733942
Rapid assessment of RNAi-mediated protein depletion by selected reaction monitoring mass spectrometry. PMID:23713831
Viruses and antiviral immunity in Drosophila. PMID:23680639
In vitro imaging of primary neural cell culture from Drosophila. PMID:23598446
Genome-wide RNAi screening identifies genes inhibiting the migration of glioblastoma cells. PMID:23593504
TALEN-based gene disruption in the dengue vector Aedes aegypti. PMID:23555893
Orai1-NFAT signalling pathway triggered by T cell receptor stimulation. PMID:23483280
RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function. PMID:23468663
A functional genomics screen for microRNA regulators of NF-kappaB signaling. PMID:23448136
A whole-genome RNA interference screen for human cell factors affecting myxoma virus replication. PMID:23408614
Quantitative genetic-interaction mapping in mammalian cells. PMID:23407553
Human pluripotent stem cells: an emerging model in developmental biology. PMID:23362344
C911: A bench-level control for sequence specific siRNA off-target effects. PMID:23251657
An arrayed genome-scale lentiviral-enabled short hairpin RNA screen identifies lethal and rescuer gene candidates. PMID:23198867
A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. PMID:23177739
Using Multiple Phenotype Assays and Epistasis Testing to Enhance the Reliability of RNAi Screening and Identify Regulators of Muscle Protein Degradation. PMID:23152949
Progress towards Drosophila epithelial cell culture. PMID:23097097
Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. PMID:23006893
A simple method for analyzing actives in random RNAi screens: introducing the "H Score" for hit nomination & gene prioritization. PMID:22934950
[Cancer stem cells and high-throughput screening methods]. PMID:22907581
siRNA off-target effects in genome-wide screens identify signaling pathway members. PMID:22645644
MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma. PMID:22589389
A direct look at RNAi screens. PMID:22531120
Single-cell analysis of population context advances RNAi screening at multiple levels. PMID:22531119
Discovery of small molecule cancer drugs: successes, challenges and opportunities. PMID:22440008
Bottlenecks caused by software gaps in miRNA and RNAi research. PMID:22362409
Generation of stable Drosophila cell lines using multicistronic vectors. PMID:22355594
A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens. PMID:22343343
RNA interference in Cryptococcus neoformans. PMID:22328374
Drosophila models of proteinopathies: the little fly that could. PMID:22288402
Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. PMID:22174071
Modeling human neurodegenerative diseases in transgenic systems. PMID:22167414
FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update. PMID:22067456
Systems-biology approaches to discover anti-viral effectors of the human innate immune response. PMID:21994773
Deconstructing host-pathogen interactions in Drosophila. PMID:21979942
Drosophila as a tool for personalized medicine: a primer. PMID:21977050
RNAi screening: new approaches, understandings, and organisms. PMID:21953743
Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype. PMID:21893601
A functional genomic screen combined with time-lapse microscopy uncovers a novel set of genes involved in dorsal closure of Drosophila embryos. PMID:21799798
Streamlined platform for short hairpin RNA interference and transgenesis in cultured mammalian cells. PMID:21768390
Drosophila RNAi screening in a postgenomic world. PMID:21752787
Genome-wide screening using RNA interference to study host factors in viral replication and pathogenesis. PMID:21727185
Search for limiting factors in the RNAi pathway in silkmoth tissues and the Bm5 cell line: the RNA-binding proteins R2D2 and Translin. PMID:21637842
A high-throughput platform for lentiviral overexpression screening of the human ORFeome. PMID:21629697
Functional toxicogenomics: mechanism-centered toxicology. PMID:21614174
A protein network-guided screen for cell cycle regulators in Drosophila. PMID:21548953
From RNAi screens to molecular function in embryonic stem cells. PMID:21526416
Interactome networks and human disease. PMID:21414488
Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2. PMID:21401928
Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen. PMID:21383842
False negative rates in Drosophila cell-based RNAi screens: a case study. PMID:21251254
Evolutionary crossroads in developmental biology: Dictyostelium discoideum. PMID:21205784
Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila. PMID:21197652
Appraising the roles of CBLL1 and the ubiquitin/proteasome system for flavivirus entry and replication. PMID:21191016
Identification of functional elements and regulatory circuits by Drosophila modENCODE. PMID:21177974
The transcriptional diversity of 25 Drosophila cell lines. PMID:21177962
Vigilance and validation: Keys to success in RNAi screening. PMID:21142076
Allostery and population shift in drug discovery. PMID:20884293
Inbreeding and epigenetics: beneficial as well as deleterious effects. PMID:20661256
In vivo RNAi: today and tomorrow. PMID:20534712 -
Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays
PubMed citations: 134.
134 articles citing: Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays
CRISPR/Cas- and Topical RNAi-Based Technologies for Crop Management and Improvement: Reviewing the Risk Assessment and Challenges Towards a More Sustainable Agriculture. PMID:35837551
U1A is a positive regulator of the expression of heterologous and cellular genes involved in cell proliferation and migration. PMID:35664701
Small ORFs as New Regulators of Pri-miRNAs and miRNAs Expression in Human and Drosophila. PMID:35628573
RNAi for Western Corn Rootworm Management: Lessons Learned, Challenges, and Future Directions. PMID:35055900
Innate and adaptive resistance to RNAi: a major challenge and hurdle to the development of double stranded RNA-based pesticides. PMID:34881161
Establishing RNAi for basic research and pest control and identification of the most efficient target genes for pest control: a brief guide. PMID:34863212
Discovering antiviral restriction factors and pathways using genetic screens. PMID:34020727
RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila. PMID:33983927
dsRNA-Mediated Pest Management of Tuta absoluta Is Compatible with Its Biological Control Agent Nesidiocoris tenuis. PMID:33804809
Off-target effects of RNAi correlate with the mismatch rate between dsRNA and non-target mRNA. PMID:33397184
Identification of the enzymes responsible for m2,2G and acp3U formation on cytosolic tRNA from insects and plants. PMID:33253256
Debugging: Strategies and Considerations for Efficient RNAi-Mediated Control of the Whitefly Bemisia tabaci. PMID:33105847
An Efficient Screen for Cell-Intrinsic Factors Identifies the Chaperonin CCT and Multiple Conserved Mechanisms as Mediating Dendrite Morphogenesis. PMID:33100975
Dengue virus dominates lipid metabolism modulations in Wolbachia-coinfected Aedes aegypti. PMID:32948809
Programmable RNA Targeting Using CasRx in Flies. PMID:32584145
Problem Formulation for Off-Target Effects of Externally Applied Double-Stranded RNA-Based Products for Pest Control. PMID:32373142
G-protein signaling is required for increasing germline stem cell division frequency in response to mating in Drosophila males. PMID:32127590
The Transcriptional Response of Aedes aegypti with Variable Extrinsic Incubation Periods for Dengue Virus. PMID:30335126
An efficient and multiple target transgenic RNAi technique with low toxicity in Drosophila. PMID:30297884
Molecular Cloning and Effects of Tm14-3-3ζ-Silencing on Larval Survivability Against E. coli and C. albicans in Tenebrio molitor. PMID:29966317
p38b and JAK-STAT signaling protect against Invertebrate iridescent virus 6 infection in Drosophila. PMID:29746571
RNA Interference (RNAi) Screening in Drosophila. PMID:29487145
Implementing the sterile insect technique with RNA interference - a review. PMID:29200471
dTBC1D7 regulates systemic growth independently of TSC through insulin signaling. PMID:29187524
Evaluation and control of miRNA-like off-target repression for RNA interference. PMID:28905147
Host Cell S Phase Restricts Legionella pneumophila Intracellular Replication by Destabilizing the Membrane-Bound Replication Compartment. PMID:28830950
Investigating Engineered Ribonucleoprotein Particles to Improve Oral RNAi Delivery in Crop Insect Pests. PMID:28503153
The Noncell Autonomous Requirement of Proboscipedia for Growth and Differentiation of the Distal Maxillary Palp during Metamorphosis of Drosophila melanogaster. PMID:28357140
Ras-like family small GTPases genes in Nilaparvata lugens: Identification, phylogenetic analysis, gene expression and function in nymphal development. PMID:28241066
Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. PMID:27795562
The diversity of insect antiviral immunity: insights from viruses. PMID:27232381
Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human. PMID:27100653
The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testis. PMID:26792023
The genetic regulatory network centered on Pto-Wuschela and its targets involved in wood formation revealed by association studies. PMID:26549216
Non-Target Effects of Green Fluorescent Protein (GFP)-Derived Double-Stranded RNA (dsRNA-GFP) Used in Honey Bee RNA Interference (RNAi) Assays. PMID:26466797
Large scale RNAi screen in Tribolium reveals novel target genes for pest control and the proteasome as prime target. PMID:26334912
Reagent and Data Resources for Investigation of RNA Binding Protein Functions in Drosophila melanogaster Cultured Cells. PMID:26199285
Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects. PMID:26197079
MAPK signaling pathway alters expression of midgut ALP and ABCC genes and causes resistance to Bacillus thuringiensis Cry1Ac toxin in diamondback moth. PMID:25875245
Ecdysteroids regulate the levels of Molt-Inhibiting Hormone (MIH) expression in the blue crab, Callinectes sapidus. PMID:25849453
A systems-level interrogation identifies regulators of Drosophila blood cell number and survival. PMID:25749252
Population distribution analyses reveal a hierarchy of molecular players underlying parallel endocytic pathways. PMID:24971745
Genes involved in centrosome-independent mitotic spindle assembly in Drosophila S2 cells. PMID:24255106
Limited agreement of independent RNAi screens for virus-required host genes owes more to false-negative than false-positive factors. PMID:24068911
Conserved regulators of nucleolar size revealed by global phenotypic analyses. PMID:23962978
Validating RNAi phenotypes in Drosophila using a synthetic RNAi-resistant transgene. PMID:23950943
The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine. PMID:23942514
UP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents. PMID:23792952
Drosophila melanogaster muscle LIM protein and alpha-actinin function together to stabilize muscle cytoarchitecture: a potential role for Mlp84B in actin-crosslinking. PMID:23606669
The homeobox transcription factor cut coordinates patterning and growth during Drosophila airway remodeling. PMID:23423438
Identification of Drosophila gene products required for phagocytosis of Leishmania donovani. PMID:23272175
Analysis of Legionella infection using RNAi in Drosophila cells. PMID:23150401
Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies. PMID:23028964
An efficient RNA interference screening strategy for gene functional analysis. PMID:22988976
A genome-wide screen identifies genes that affect somatic homolog pairing in Drosophila. PMID:22870396
Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation. PMID:22844249
Kinesin heavy chain function in Drosophila glial cells controls neuronal activity. PMID:22649226
Identification of genes that promote or antagonize somatic homolog pairing using a high-throughput FISH-based screen. PMID:22589731
A genome-wide RNAi screen identifies regulators of cholesterol-modified hedgehog secretion in Drosophila. PMID:22432040
Roles of major facilitator superfamily transporters in phosphate response in Drosophila. PMID:22359624
Analysis of glial cell development and function in Drosophila. PMID:22194269
Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. PMID:22174071
FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update. PMID:22067456
RNAi screening: new approaches, understandings, and organisms. PMID:21953743
A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion. PMID:21886182
RNA-mediated silencing in Algae: biological roles and tools for analysis of gene function. PMID:21803865
Drosophila RNAi screening in a postgenomic world. PMID:21752787
A protein network-guided screen for cell cycle regulators in Drosophila. PMID:21548953
A genome-scale shRNA resource for transgenic RNAi in Drosophila. PMID:21460824
False negative rates in Drosophila cell-based RNAi screens: a case study. PMID:21251254
Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. PMID:21239477
A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. PMID:21205937
Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila. PMID:21197652
Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development. PMID:21145318
RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PMID:20976050
RNAi experiments in D. melanogaster: solutions to the overlooked problem of off-targets shared by independent dsRNAs. PMID:20957038
The FLIGHT Drosophila RNAi database: 2010 update. PMID:20855970
Gene-knockdown in the honey bee mite Varroa destructor by a non-invasive approach: studies on a glutathione S-transferase. PMID:20712880
The cytoskeletal regulator zyxin is required for viability in Drosophila melanogaster. PMID:20648572
Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia. PMID:20585616
Design and evaluation of genome-wide libraries for RNA interference screens. PMID:20550664
An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. PMID:20540764
In vivo RNAi: today and tomorrow. PMID:20534712
Vectors and parameters that enhance the efficacy of RNAi-mediated gene disruption in transgenic Drosophila. PMID:20534445
E-RNAi: a web application for the multi-species design of RNAi reagents--2010 update. PMID:20444868
Genomic screening with RNAi: results and challenges. PMID:20367032
Systems survey of endocytosis by multiparametric image analysis. PMID:20190736
Expression in aneuploid Drosophila S2 cells. PMID:20186269
In vivo RNAi rescue in Drosophila melanogaster with genomic transgenes from Drosophila pseudoobscura. PMID:20126626
A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. PMID:20100940
In vitro manipulation of gene expression in larval Schistosoma: a model for postgenomic approaches in Trematoda. PMID:19961646
Insights to transcriptional networks by using high throughput RNAi strategies. PMID:19952073
Modulation of motor behavior by dopamine and the D1-like dopamine receptor AmDOP2 in the honey bee. PMID:19945462
A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. PMID:19942856
GenomeRNAi: a database for cell-based RNAi phenotypes. 2009 update. PMID:19910367
RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. PMID:19789644
Cross-species RNAi rescue platform in Drosophila melanogaster. PMID:19720858
Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interference. PMID:19668375
A Drosophila resource of transgenic RNAi lines for neurogenetics. PMID:19487563
Genome-wide silencing in Drosophila captures conserved apoptotic effectors. PMID:19483676
A novel method for tissue-specific RNAi rescue in Drosophila. PMID:19483100
Generation of an external guide sequence library for a reverse genetic screen in Caenorhabditis elegans. PMID:19457250
A network-based integrative approach to prioritize reliable hits from multiple genome-wide RNAi screens in Drosophila. PMID:19435510
Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model. PMID:19380309
Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. PMID:19363474
Evidence of a tick RNAi pathway by comparative genomics and reverse genetics screen of targets with known loss-of-function phenotypes in Drosophila. PMID:19323841
Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology. PMID:19265526
Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. PMID:19264959
Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network. PMID:19261841
Steroid hormone control of cell death and cell survival: molecular insights using RNAi. PMID:19214204
Aurora-A kinase is essential for bipolar spindle formation and early development. PMID:19075002
COPI complex is a regulator of lipid homeostasis. PMID:19067489
CellProfiler Analyst: data exploration and analysis software for complex image-based screens. PMID:19014601
A genomic approach to myoblast fusion in Drosophila. PMID:18979251
Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. PMID:18797514
Identification of neural outgrowth genes using genome-wide RNAi. PMID:18604272
A simplified miRNA-based gene silencing method for Drosophila melanogaster. PMID:18598689
Identification of JAK/STAT pathway regulators--insights from RNAi screens. PMID:18586112
Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. PMID:18519643
Hsp60D is essential for caspase-mediated induced apoptosis in Drosophila melanogaster. PMID:18506601
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. PMID:18408709
RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. PMID:18359903
Definition of global and transcript-specific mRNA export pathways in metazoans. PMID:18086857
Functional screening identifies miR-315 as a potent activator of Wingless signaling. PMID:17989227
Drosophila bestrophin-1 chloride current is dually regulated by calcium and cell volume. PMID:17968025
Segregation of odor identity and intensity during odor discrimination in Drosophila mushroom body. PMID:17914903
A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. PMID:17903264
Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. PMID:17676955
P21 gene knock down does not identify genetic effectors seen with gene knock out. PMID:17611398
Adipocyte differentiation induced using nonspecific siRNA controls in cultured human mesenchymal stem cells. PMID:17556710
Genes required for mitotic spindle assembly in Drosophila S2 cells. PMID:17412918
Stereotypic founder cell patterning and embryonic muscle formation in Drosophila require nautilus (MyoD) gene function. PMID:17376873
Applications of high-throughput RNA interference screens to problems in cell and developmental biology. PMID:17244760
GenomeRNAi: a database for cell-based RNAi phenotypes. PMID:17135194 -
Design and implementation of high-throughput RNAi screens in cultured Drosophila cells
PubMed citations: 62.
62 articles citing: Design and implementation of high-throughput RNAi screens in cultured Drosophila cells
Insights Into the Biogenesis and Emerging Functions of Lipid Droplets From Unbiased Molecular Profiling Approaches. PMID:35756995
Interplay Between BALL and CREB Binding Protein Maintains H3K27 Acetylation on Active Genes in Drosophila. PMID:34650987
Discovering antiviral restriction factors and pathways using genetic screens. PMID:34020727
Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis in Drosophila. PMID:33937259
Chromosome territory formation attenuates the translocation potential of cells. PMID:31682226
TRiC/CCT chaperonins are essential for organ growth by interacting with insulin/TOR signaling in Drosophila. PMID:30792539
Whole genome screen reveals a novel relationship between Wolbachia levels and Drosophila host translation. PMID:30422992
Condensin II drives large-scale folding and spatial partitioning of interphase chromosomes in Drosophila nuclei. PMID:30001329
RNA Interference (RNAi) Screening in Drosophila. PMID:29487145
Host Cell S Phase Restricts Legionella pneumophila Intracellular Replication by Destabilizing the Membrane-Bound Replication Compartment. PMID:28830950
Quick 96FASP for high throughput quantitative proteome analysis. PMID:28669814
RNA interference-mediated knockdown of the hydroxyacid-oxoacid transhydrogenase gene decreases thiamethoxam resistance in adults of the whitefly Bemisia tabaci. PMID:28117358
Phage-mediated Delivery of Targeted sRNA Constructs to Knock Down Gene Expression in E. coli. PMID:27023729
Focused Screening Identifies Evoxine as a Small Molecule That Counteracts CO2-Induced Immune Suppression. PMID:26701099
Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen. PMID:26643480
Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis. PMID:26333836
ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation. PMID:25915123
Signaling networks converge on TORC1-SREBP activity to promote endoplasmic reticulum homeostasis. PMID:25007267
Luciferase reporter assay in Drosophila and mammalian tissue culture cells. PMID:24652620
A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila. PMID:24643257
RNAi screening in Drosophila cells and in vivo. PMID:24576618
Function of the Drosophila receptor guanylyl cyclase Gyc76C in PlexA-mediated motor axon guidance. PMID:24284209
Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition. PMID:23788431
Viruses and antiviral immunity in Drosophila. PMID:23680639
A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila. PMID:23665228
Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets. PMID:23515685
Adapting human pluripotent stem cells to high-throughput and high-content screening. PMID:23257981
Analysis of Legionella infection using RNAi in Drosophila cells. PMID:23150401
Cell-based genomic screening: elucidating virus-host interactions. PMID:23122855
Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. PMID:23006893
A genome-wide screen identifies genes that affect somatic homolog pairing in Drosophila. PMID:22870396
Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation. PMID:22844249
Identification of genes that promote or antagonize somatic homolog pairing using a high-throughput FISH-based screen. PMID:22589731
Using the Drosophila melanogaster D17-c3 cell culture system to study cell motility. PMID:21959242
RNAi screening: new approaches, understandings, and organisms. PMID:21953743
An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells. PMID:21853325
Automated microscopy and image analysis for androgen receptor function. PMID:21796534
Effects of HBV Genetic Variability on RNAi Strategies. PMID:21760994
Drosophila RNAi screening in a postgenomic world. PMID:21752787
A systems biological view of intracellular pathogens. PMID:21349090
False negative rates in Drosophila cell-based RNAi screens: a case study. PMID:21251254
Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. PMID:21239477
A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. PMID:21205937
Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome. PMID:21149573
Hormone receptor-like in 96 and Broad-Complex modulate phenobarbital induced transcription of cytochrome P450 CYP6D1 in Drosophila S2 cells. PMID:21029232
RNAi screening for host factors involved in Vaccinia virus infection using Drosophila cells. PMID:20834214
Design and evaluation of genome-wide libraries for RNA interference screens. PMID:20550664
Genomic screening with RNAi: results and challenges. PMID:20367032
GenomeRNAi: a database for cell-based RNAi phenotypes. 2009 update. PMID:19910367
Culture of Drosophila primary cells dissociated from gastrula embryos and their use in RNAi screening. PMID:19798083
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. PMID:19797662
RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. PMID:19789644
Identification of survival genes in human glioblastoma cells by small interfering RNA screening. PMID:19783622
Implications of chimaeric non-co-linear transcripts. PMID:19741701
Cross-species RNAi rescue platform in Drosophila melanogaster. PMID:19720858
Statistical methods for analysis of high-throughput RNA interference screens. PMID:19644458
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. PMID:19590015
A network of conserved damage survival pathways revealed by a genomic RNAi screen. PMID:19543366
Gene silencing in the marine diatom Phaeodactylum tricornutum. PMID:19487243
An analysis of normalization methods for Drosophila RNAi genomic screens and development of a robust validation scheme. PMID:18753689
Identification of JAK/STAT pathway regulators--insights from RNAi screens. PMID:18586112
Genomic RNAi screening in Drosophila S2 cells: what have we learned about host-pathogen interactions? PMID:18539520 -
FlyRNAi: the Drosophila RNAi screening center database
PubMed citations: 46.
46 articles citing: FlyRNAi: the Drosophila RNAi screening center database
RNA-binding FMRP and Staufen sequentially regulate the Coracle scaffold to control synaptic glutamate receptor and bouton development. PMID:35394012
Neuron-Specific FMRP Roles in Experience-Dependent Remodeling of Olfactory Brain Innervation during an Early-Life Critical Period. PMID:33402421
FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2021 update. PMID:33104800
The Drosophila melanogaster Rab GAP RN-tre cross-talks with the Rho1 signaling pathway to regulate nonmuscle myosin II localization and function. PMID:32816624
tRNA 2'-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila. PMID:31943105
Activity-Dependent Remodeling of Drosophila Olfactory Sensory Neuron Brain Innervation during an Early-Life Critical Period. PMID:30755492
Feeding difficulties, a key feature of the Drosophila NDUFS4 mitochondrial disease model. PMID:29590638
Host Cell S Phase Restricts Legionella pneumophila Intracellular Replication by Destabilizing the Membrane-Bound Replication Compartment. PMID:28830950
Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks. PMID:28628606
FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2017 update. PMID:27924039
PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications. PMID:26283093
Altering the sex determination pathway in Drosophila fat body modifies sex-specific stress responses. PMID:24789992
The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth. PMID:24173801
UP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents. PMID:23792952
Identification of Drosophila gene products required for phagocytosis of Leishmania donovani. PMID:23272175
The Drosophila melanogaster host model. PMID:22368770
PubChem's BioAssay Database. PMID:22140110
modMine: flexible access to modENCODE data. PMID:22080565
FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update. PMID:22067456
An integrative approach to ortholog prediction for disease-focused and other functional studies. PMID:21880147
A protein network-guided screen for cell cycle regulators in Drosophila. PMID:21548953
False negative rates in Drosophila cell-based RNAi screens: a case study. PMID:21251254
Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. PMID:21239477
Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila. PMID:21212741
The FLIGHT Drosophila RNAi database: 2010 update. PMID:20855970
A genome-wide gene function prediction resource for Drosophila melanogaster. PMID:20711346
Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia. PMID:20585616
In vivo RNAi: today and tomorrow. PMID:20534712
Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities. PMID:20482787
web cellHTS2: a web-application for the analysis of high-throughput screening data. PMID:20385013
Automated microscopy for high-content RNAi screening. PMID:20176920
GenomeRNAi: a database for cell-based RNAi phenotypes. 2009 update. PMID:19910367
Gene networks in Drosophila melanogaster: integrating experimental data to predict gene function. PMID:19758432
A network-based integrative approach to prioritize reliable hits from multiple genome-wide RNAi screens in Drosophila. PMID:19435510
Evidence of a tick RNAi pathway by comparative genomics and reverse genetics screen of targets with known loss-of-function phenotypes in Drosophila. PMID:19323841
Steroid hormone control of cell death and cell survival: molecular insights using RNAi. PMID:19214204
Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. PMID:18797514
Identification of neural outgrowth genes using genome-wide RNAi. PMID:18604272
Identification of JAK/STAT pathway regulators--insights from RNAi screens. PMID:18586112
Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body. PMID:17982450
Applications of high-throughput RNA interference screens to problems in cell and developmental biology. PMID:17244760
GenomeRNAi: a database for cell-based RNAi phenotypes. PMID:17135194
CellProfiler: image analysis software for identifying and quantifying cell phenotypes. PMID:17076895
The proteins of human chromosome 21. PMID:17048356
PhenomicDB: a new cross-species genotype/phenotype resource. PMID:16982638
One hundred years of high-throughput Drosophila research. PMID:16821132 -
FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update
PubMed citations: 29.
29 articles citing: FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update
Methods for Delivery of dsRNAs for Agricultural Pest Control: The Case of Lepidopteran Pests. PMID:34495524
CG7379 and ING1 suppress cancer cell invasion by maintaining cell-cell junction integrity. PMID:34493070
Discovering antiviral restriction factors and pathways using genetic screens. PMID:34020727
FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2021 update. PMID:33104800
Drosophila ELYS regulates Dorsal dynamics during development. PMID:31941789
RNA Interference (RNAi) Screening in Drosophila. PMID:29487145
Host Cell S Phase Restricts Legionella pneumophila Intracellular Replication by Destabilizing the Membrane-Bound Replication Compartment. PMID:28830950
PubChem BioAssay: A Decade's Development toward Open High-Throughput Screening Data Sharing. PMID:28346087
The 24th annual Nucleic Acids Research database issue: a look back and upcoming changes. PMID:28053160
FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2017 update. PMID:27924039
GenomeCRISPR - a database for high-throughput CRISPR/Cas9 screens. PMID:27789686
Using FlyBase, a Database of Drosophila Genes and Genomes. PMID:27730573
A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes. PMID:27129311
FlyBase portals to human disease research using Drosophila models. PMID:26935103
The Transgenic RNAi Project at Harvard Medical School: Resources and Validation. PMID:26320097
Reagent and Data Resources for Investigation of RNA Binding Protein Functions in Drosophila melanogaster Cultured Cells. PMID:26199285
EHFPI: a database and analysis resource of essential host factors for pathogenic infection. PMID:25414353
Leigh syndrome in Drosophila melanogaster: morphological and biochemical characterization of Surf1 post-transcriptional silencing. PMID:25164807
Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines. PMID:24985917
In Vivo RNAi-Based Screens: Studies in Model Organisms. PMID:24705267
Resources for functional genomics studies in Drosophila melanogaster. PMID:24653003
RNAi screening in Drosophila cells and in vivo. PMID:24576618
Functional characterization of drim2, the Drosophila melanogaster homolog of the yeast mitochondrial deoxynucleotide transporter. PMID:24469456
Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. PMID:24240319
Conserved regulators of nucleolar size revealed by global phenotypic analyses. PMID:23962978
FlyPrimerBank: an online database for Drosophila melanogaster gene expression analysis and knockdown evaluation of RNAi reagents. PMID:23893746
Invertebrate models of dystonia. PMID:23814534
UP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents. PMID:23792952
Genetic determinants of phosphate response in Drosophila. PMID:23520455 -
False negative rates in Drosophila cell-based RNAi screens: a case study
PubMed citations: 28.
28 articles citing: False negative rates in Drosophila cell-based RNAi screens: a case study
A Drosophila RNAi screen reveals conserved glioblastoma-related adhesion genes that regulate collective cell migration. PMID:34849760
CRISPR Technology for Breast Cancer: Diagnostics, Modeling, and Therapy. PMID:32832592
Genome-wide RNAi screen in Drosophila reveals Enok as a novel trithorax group regulator. PMID:31547845
Genome-scale CRISPR knockout screen identifies TIGAR as a modifier of PARP inhibitor sensitivity. PMID:31508509
Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila. PMID:31068592
An efficient and multiple target transgenic RNAi technique with low toxicity in Drosophila. PMID:30297884
New tools for old drugs: Functional genetic screens to optimize current chemotherapy. PMID:29499836
Multiplex shRNA Screening of Germ Cell Development by in Vivo Transfection of Mouse Testis. PMID:27856695
Genetic dissection of intraspecific variation in a male-specific sexual trait in Drosophila melanogaster. PMID:27530909
Functional Genomic Strategies for Elucidating Human-Virus Interactions: Will CRISPR Knockout RNAi and Haploid Cells? PMID:26997589
Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM. PMID:26864203
Reagent and Data Resources for Investigation of RNA Binding Protein Functions in Drosophila melanogaster Cultured Cells. PMID:26199285
Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9. PMID:26041264
RNA-guided CRISPR-Cas technologies for genome-scale investigation of disease processes. PMID:25888285
Mitochondrial targets for pharmacological intervention in human disease. PMID:25367773
Integration of biological data by kernels on graph nodes allows prediction of new genes involved in mitotic chromosome condensation. PMID:24943848
In Vivo RNAi-Based Screens: Studies in Model Organisms. PMID:24705267
RNAi screening in Drosophila cells and in vivo. PMID:24576618
Genetic screens in human cells using the CRISPR-Cas9 system. PMID:24336569
Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle. PMID:23990783
Functional genomic analyses of two morphologically distinct classes of Drosophila sensory neurons: post-mitotic roles of transcription factors in dendritic patterning. PMID:23977298
On the role of PDZ domain-encoding genes in Drosophila border cell migration. PMID:23173089
Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. PMID:23006893
The Drosophila Arf1 homologue Arf79F is essential for lamellipodium formation. PMID:22992458
Posterior association networks and functional modules inferred from rich phenotypes of gene perturbations. PMID:22761558
Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. PMID:22174071
FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update. PMID:22067456
RNAi screening: new approaches, understandings, and organisms. PMID:21953743 -
Cross-species RNAi rescue platform in Drosophila melanogaster
PubMed citations: 28.
28 articles citing: Cross-species RNAi rescue platform in Drosophila melanogaster
The cecropin-prophenoloxidase regulatory mechanism is a cross-species physiological function in mosquitoes. PMID:35712072
cdc37 is essential for JNK pathway activation and wound closure in Drosophila. PMID:31483695
Alcohol sedation in adult Drosophila is regulated by Cysteine proteinase-1 in cortex glia. PMID:31286069
Generating and working with Drosophila cell cultures: Current challenges and opportunities. PMID:30561900
Gene Tagging Strategies To Assess Protein Expression, Localization, and Function in Drosophila. PMID:28978772
Genome engineering: Drosophila melanogaster and beyond. PMID:26447401
The Transgenic RNAi Project at Harvard Medical School: Resources and Validation. PMID:26320097
RNAi screening comes of age: improved techniques and complementary approaches. PMID:25145850
The Little Fly that Could: Wizardry and Artistry of Drosophila Genomics. PMID:24827974
In Vivo RNAi-Based Screens: Studies in Model Organisms. PMID:24705267
Resources for functional genomics studies in Drosophila melanogaster. PMID:24653003
Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster. PMID:24583113
RNAi screening in Drosophila cells and in vivo. PMID:24576618
Validating RNAi phenotypes in Drosophila using a synthetic RNAi-resistant transgene. PMID:23950943
MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. PMID:23300484
The genetic analysis of functional connectomics in Drosophila. PMID:23084874
Kinesin heavy chain function in Drosophila glial cells controls neuronal activity. PMID:22649226
Multispecies-compatible antitumor effects of a cross-species small-interfering RNA against mammalian target of rapamycin. PMID:22562582
FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update. PMID:22067456
Genetic manipulation of genes and cells in the nervous system of the fruit fly. PMID:22017985
RNAi screening: new approaches, understandings, and organisms. PMID:21953743
Drosophila RNAi screening in a postgenomic world. PMID:21752787
False negative rates in Drosophila cell-based RNAi screens: a case study. PMID:21251254
Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila. PMID:21197652
A molecularly defined duplication set for the X chromosome of Drosophila melanogaster. PMID:20876565
Reverse genetics in eukaryotes. PMID:20812916
In vivo RNAi: today and tomorrow. PMID:20534712
In vivo RNAi rescue in Drosophila melanogaster with genomic transgenes from Drosophila pseudoobscura. PMID:20126626 - https://doi.org/10.1093/nar/gkaa936
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More detailed information about this field from each metasource.
cell line
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
rna interference
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
rnai screening
metasource: Fairsharing.org
version: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
rna sequence databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
genomics databases (non-vertebrate)
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
invertebrate genome databases
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657
rnai experiment
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:45.497298
rna
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:45.497298
compound libraries and screening
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:45.497298
electron microscopy
metasource: bio.tools
version: extracted_at: 2022-11-04T11:34:45.497298
Tags
More detailed information about this field from each metasource.
cell line
metasource: Fairsharing.orgversion: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
rna interference
metasource: Fairsharing.orgversion: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
rnai screening
metasource: Fairsharing.orgversion: FAIRsharing.org: DRSC-FGR; DRSC Functional Genomics Resources; DOI: https://doi.org/10.25504/FAIRsharing.sbnhkq; Last edited: Jan. 8, 2019, 1:13 p.m.; Last accessed: Jan 03 2022 7:09 p.m.
rna sequence databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
genomics databases (non-vertebrate)
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
invertebrate genome databases
metasource: Nucleic Acid Research database catalogueversion: extracted_at: 2022-11-04T11:16:25.468657
rnai experiment
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:45.497298
rna
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:45.497298
compound libraries and screening
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:45.497298
electron microscopy
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:34:45.497298
cell line rna interference rnai screening rna sequence genomics invertebrate genome rnai experiment rna compound libraries and screening electron microscopy
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