CoVex
CoVex is an interactive online platform for SARS-CoV-2 host interactome exploration and drug (target) identification. CoVex integrates virus-human protein interactions, human protein-protein interactions, and drug-target interactions. It allows visual exploration of the virus-host interactome and implements systems medicine algorithms for network-based prediction of drug candidates. Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics.
Description
More detailed information about this field from each metasource.
CoVex is an interactive online platform for SARS-CoV-2 host interactome exploration and drug (target) identification. CoVex integrates virus-human protein interactions, human protein-protein interactions, and drug-target interactions. It allows visual exploration of the virus-host interactome and implements systems medicine algorithms for network-based prediction of drug candidates. Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics.
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:28:23.731866
Webpage:
https://exbio.wzw.tum.de/covex/Webpage
More detailed information about this field from each metasource.
https://exbio.wzw.tum.de/covex/
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:28:23.731866
Publications:
Publications
More detailed information about this field from each metasource.
Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
PMID: 32665542
metasource: bio.tools
version: extracted_at: 2022-11-04T11:28:23.731866
Publications
More detailed information about this field from each metasource.
Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
PMID: 32665542
metasource: bio.tools
version: extracted_at: 2022-11-04T11:28:23.731866
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Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
PubMed citations: 69.
69 articles citing: Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
Discovery of Potential Therapeutic Drugs for COVID-19 Through Logistic Matrix Factorization With Kernel Diffusion. PMID:35295301
CTCFL regulates the PI3K-Akt pathway and it is a target for personalized ovarian cancer therapy. PMID:35132075
Montelukast is a dual-purpose inhibitor of SARS-CoV-2 infection and virus-induced IL-6 expression identified by structure-based drug repurposing. PMID:35126884
Repurposing of Drugs for SARS-CoV-2 Using Inverse Docking Fingerprints. PMID:35028304
Interpretable network propagation with application to expanding the repertoire of human proteins that interact with SARS-CoV-2. PMID:34966926
Mediterranean Diet a Potential Strategy against SARS-CoV-2 Infection: A Narrative Review. PMID:34946334
Proteomics advances towards developing SARS-CoV-2 therapeutics using in silico drug repurposing approaches. PMID:34906319
Host directed therapies: COVID-19 and beyond. PMID:34870156
Network analytics for drug repurposing in COVID-19. PMID:34864885
A multitask transfer learning framework for the prediction of virus-human protein-protein interactions. PMID:34837942
Network medicine for disease module identification and drug repurposing with the NeDRex platform. PMID:34824199
Data science approaches to confronting the COVID-19 pandemic: a narrative review. PMID:34802267
Integrative COVID-19 biological network inference with probabilistic core decomposition. PMID:34791019
Machine learning and network medicine approaches for drug repositioning for COVID-19. PMID:34778851
IID 2021: towards context-specific protein interaction analyses by increased coverage, enhanced annotation and enrichment analysis. PMID:34755877
Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis. PMID:34750486
Identification and Development of Therapeutics for COVID-19. PMID:34726496
COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19. PMID:34593915
A Vision of Future Healthcare: Potential Opportunities and Risks of Systems Medicine from a Citizen and Patient Perspective-Results of a Qualitative Study. PMID:34574802
Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization. PMID:34571172
Network neighbors of viral targets and differentially expressed genes in COVID-19 are drug target candidates. PMID:34556735
Exploring the Molecular Mechanism of Liuwei Dihuang Pills for Treating Diabetic Nephropathy by Combined Network Pharmacology and Molecular Docking. PMID:34552655
Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics Approaches. PMID:34519533
Drug repurposing against coronavirus disease 2019 (COVID-19): A review. PMID:34513115
Identification of potential therapeutic targets and mechanisms of COVID-19 through network analysis and screening of chemicals and herbal ingredients. PMID:34505138
Advances in the computational landscape for repurposed drugs against COVID-19. PMID:34339864
SARS-CoV-2 Antiviral Therapy. PMID:34319150
Integrative resource for network-based investigation of COVID-19 combinatorial drug repositioning and mechanism of action. PMID:34278363
Search, Identification, and Design of Effective Antiviral Drugs Against Pandemic Human Coronaviruses. PMID:34258743
In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies. PMID:34237472
Identification of SARS-CoV-2-induced pathways reveals drug repurposing strategies. PMID:34193418
Can the COVID-19 Pandemic Disrupt the Current Drug Development Practices? PMID:34064287
Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection. PMID:34031419
Graphene Oxide Nanosheets Interact and Interfere with SARS-CoV-2 Surface Proteins and Cell Receptors to Inhibit Infectivity. PMID:33988903
Exploring antibody repurposing for COVID-19: beyond presumed roles of therapeutic antibodies. PMID:33986382
The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell function. PMID:33941085
Network medicine framework for identifying drug-repurposing opportunities for COVID-19. PMID:33906951
The Relevance of Bioinformatics Applications in the Discovery of Vaccine Candidates and Potential Drugs for COVID-19 Treatment. PMID:33795932
Conflicting and ambiguous names of overlapping ORFs in the SARS-CoV-2 genome: A homology-based resolution. PMID:33774510
Structure insights of SARS-CoV-2 open state envelope protein and inhibiting through active phytochemical of ayurvedic medicinal plants from Withania somnifera. PMID:33758570
OverCOVID: an integrative web portal for SARS-CoV-2 bioinformatics resources. PMID:33735949
Brief review on repurposed drugs and vaccines for possible treatment of COVID-19. PMID:33639193
The analysis on the human protein domain targets and host-like interacting motifs for the MERS-CoV and SARS-CoV/CoV-2 infers the molecular mimicry of coronavirus. PMID:33596252
Data science in unveiling COVID-19 pathogenesis and diagnosis: evolutionary origin to drug repurposing. PMID:33592108
SARS-CoV infection crosstalk with human host cell noncoding-RNA machinery: An in-silico approach. PMID:33475497
Bioinformatics resources facilitate understanding and harnessing clinical research of SARS-CoV-2. PMID:33432321
Mapping the SARS-CoV-2-Host Protein-Protein Interactome by Affinity Purification Mass Spectrometry and Proximity-Dependent Biotin Labeling: A Rational and Straightforward Route to Discover Host-Directed Anti-SARS-CoV-2 Therapeutics. PMID:33430309
SARS-CoV-2 infection is associated with a pro-thrombotic platelet phenotype. PMID:33414384
Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach. PMID:33386025
Structure and regulation of coronavirus genomes: state-of-the-art and novel insights from SARS-CoV-2 studies. PMID:33367597
A recent origin of Orf3a from M protein across the coronavirus lineage arising by sharp divergence. PMID:33363705
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. PMID:33357464
Does tetanus vaccination contribute to reduced severity of the COVID-19 infection? PMID:33341328
Enhancement of the IFN-β-induced host signature informs repurposed drugs for COVID-19. PMID:33289002
Joining European Scientific Forces to Face Pandemics. PMID:33288385
Text mining approaches for dealing with the rapidly expanding literature on COVID-19. PMID:33279995
A review of COVID-19 biomarkers and drug targets: resources and tools. PMID:33279954
DBCOVP: A database of coronavirus virulent glycoproteins. PMID:33276297
CovMulNet19, Integrating Proteins, Diseases, Drugs, and Symptoms: A Network Medicine Approach to COVID-19. PMID:33274348
Identification of Persuasive Antiviral Natural Compounds for COVID-19 by Targeting Endoribonuclease NSP15: A Structural-Bioinformatics Approach. PMID:33271751
ACE2 Interaction Networks in COVID-19: A Physiological Framework for Prediction of Outcome in Patients with Cardiovascular Risk Factors. PMID:33233425
Molecular targets and system biology approaches for drug repurposing against SARS-CoV-2. PMID:33230386
Individuating Possibly Repurposable Drugs and Drug Targets for COVID-19 Treatment Through Hypothesis-Driven Systems Medicine Using CoVex. PMID:33164550
Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research. PMID:33147627
A review on drug repurposing applicable to COVID-19. PMID:33147623
The effects of aging on host resistance and disease tolerance to SARS-CoV-2 infection. PMID:33124149
Web tools to fight pandemics: the COVID-19 experience. PMID:33057582
Modeling Potential Autophagy Pathways in COVID-19 and Sarcoidosis. PMID:32863134
CORDITE: The Curated CORona Drug InTERactions Database for SARS-CoV-2. PMID:32619700
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molecular interactions, pathways and networks
metasource: bio.tools
version: extracted_at: 2022-11-04T11:28:23.731866
small molecules
metasource: bio.tools
version: extracted_at: 2022-11-04T11:28:23.731866
infectious disease
metasource: bio.tools
version: extracted_at: 2022-11-04T11:28:23.731866
systems medicine
metasource: bio.tools
version: extracted_at: 2022-11-04T11:28:23.731866
pharmacology
metasource: bio.tools
version: extracted_at: 2022-11-04T11:28:23.731866
Tags
More detailed information about this field from each metasource.
molecular interactions, pathways and networks
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:28:23.731866
small molecules
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:28:23.731866
infectious disease
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:28:23.731866
systems medicine
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:28:23.731866
pharmacology
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:28:23.731866
molecular interactions, pathways and networks small molecule infectious disease systems medicine pharmacology
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