CUBE-DB

Other names: Cube-DB, cube-db

Detection of functional divergence in human protein families. Cube-DB is a database of pre-evaluated conservation and specialization scores for residues in paralogous proteins belonging to multi-member families of human proteins. Protein family classification follows (largely) the classification suggested by HUGO Gene Nomenclature Committee. Sets of orthologous protein sequences were generated by mutual-best-hit strategy using full vertebrate genomes available in Ensembl. The scores, described on documentation page, are assigned to each individual residue in a protein, and presented in the form of a table (html or downloadable xls formats) and mapped, when appropriate, onto the related structure (Jmol, Pymol, Chimera).

Webpage:
http://epsf.bmad.bii.a-star.edu.sg/cube/db/html/home.html

Publications:

Tags:

classification molecular function multiple sequence alignment orthology paralogous protein polypeptide region structure protein structure gene and protein families proteins model organisms

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