Other names: ImMunoGeneTics / Gene-DB, International ImMunoGeneTics information system/Gene-DB, IMGT GENE-DB, IMGT_GENE-DB

IMGT/GENE-DB is the IMGT® comprehensive genome database for immunoglobulins (IG) and T cell receptors (TR) genes from human and mouse, and, in developement, from other vertebrate species (e.g. rat). IMGT/GENE-DB is part of IMGT®, the international ImMunoGeneTics information system® (1,2), the high-quality integrated knowledge resource specialized in IG, TR, major histocompatibility complex (MHC) of human and other vertebrate species, and related proteins of the immune system (RPI) that belong to the immunoglobulin superfamily (IgSF) and to the MHC superfamily (MhcSF). IMGT/GENE-DB annotated data are extracted from IMGT Repertoire, the global ImMunoGeneTics Web Resource, and from the IMGT/LIGM-DB database (3). All the human IMGT gene names (4,5) were approved by the Human Genome Organisation (HUGO) Nomenclature Committee (HGNC) in 1999 (6), and entered in the Genome DataBase GDB (Canada) and in LocusLink and Entrez Gene at NCBI (USA). IMGT/GENE-DB allows a search of IG and TR gene entries by locus, group, subgroup, based on the CLASSIFICATION axiom of IMGT-ONTOLOGY (7,8). A shortcut allows users to search genes by selection of gene name (according to the IMGT nomenclature) or clone name(s) (data from the "Reference sequences" and "Sequences from the literature" columns in IMGT Repertoire>Germline genes tables). IMGT/GENE-DB entries provide, for each gene, the chromosomal localization, the gene name and definition, the number of alleles, links to IMGT Repertoire and to external sequence (EMBL, GenBank, DDBJ) and genome (e.g., GDB, Entrez Gene, OMIM) databases. IMGT/GENE-DB provides for each allele the functionality, the clone names, the IMGT/LIGM-DB reference sequence accession numbers (with link to the flat file), and the "IMGT/GENE-DB reference sequences in FASTA format" (nucleotide and amino acid sequences of the coding regions extracted from the IMGT/LIGM-DB reference sequence), with gaps according to the IMGT unique numbering (9,10) (based on the IMGT Scientific chart rules and on the NUMEROTATION axiom of IMGT-ONTOLOGY). IMGT/GENE-DB was implemented by Vèronique Giudicelli, and has been available on the Web since February 2003.


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immunology t cell receptor alleles gene expression genome analysis genomics human immunogenetics immunoglobulin immunoinformatics mouse vertebrates immunology

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