From Petri Plates to Petri Nets, a revolution in yeast biology.
PMID:35142857
Genome-scale modeling of yeast metabolism: retrospectives and perspectives.
PMID:35094064
Exploring the transportome of the biosurfactant producing yeast Starmerella bombicola.
PMID:34998388
Intelligent host engineering for metabolic flux optimisation in biotechnology.
PMID:34673920
Path to improving the life cycle and quality of genome-scale models of metabolism.
PMID:34555324
Review of Machine Learning Methods for the Prediction and Reconstruction of Metabolic Pathways.
PMID:34222327
New Cross-Talks between Pathways Involved in Grapevine Infection with 'Candidatus Phytoplasma solani' Revealed by Temporal Network Modelling.
PMID:33805409
Rare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism.
PMID:33574263
Evaluating accessibility, usability and interoperability of genome-scale metabolic models for diverse yeasts species.
PMID:33428734
Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels.
PMID:33323978
Genome-scale metabolic reconstruction of the non-model yeast Issatchenkia orientalis SD108 and its application to organic acids production.
PMID:33134082
Serum Metabolomics for Biomarker Screening of Esophageal Squamous Cell Carcinoma and Esophageal Squamous Dysplasia Using Gas Chromatography-Mass Spectrometry.
PMID:33110968
Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production.
PMID:32942174
A mechanism-aware and multiomic machine-learning pipeline characterizes yeast cell growth.
PMID:32675233
A scalable method for parameter-free simulation and validation of mechanistic cellular signal transduction network models.
PMID:31934349
Evaluation of synthetic formaldehyde and methanol assimilation pathways in Yarrowia lipolytica.
PMID:31890234
Genome-Scale Metabolic Modeling from Yeast to Human Cell Models of Complex Diseases: Latest Advances and Challenges.
PMID:31602620
Ample Arsenite Bio-Oxidation Activity in Bangladesh Drinking Water Wells: A Bonanza for Bioremediation?
PMID:31398879
ChIP-exo analysis highlights Fkh1 and Fkh2 transcription factors as hubs that integrate multi-scale networks in budding yeast.
PMID:31299083
Predicting Metabolism from Gene Expression in an Improved Whole-Genome Metabolic Network Model of Danio rerio.
PMID:31216234
Current status and applications of genome-scale metabolic models.
PMID:31196170
A genome-scale metabolic network reconstruction of extremely halophilic bacterium Salinibacter ruber.
PMID:31071110
BOFdat: Generating biomass objective functions for genome-scale metabolic models from experimental data.
PMID:31009451
Systems Biology and Multi-Omics Integration: Viewpoints from the Metabolomics Research Community.
PMID:31003499
A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae.
PMID:30899000
A Data Integration Multi-Omics Approach to Study Calorie Restriction-Induced Changes in Insulin Sensitivity.
PMID:30804813
Uncovering and resolving challenges of quantitative modeling in a simplified community of interacting cells.
PMID:30794534
Consistency, Inconsistency, and Ambiguity of Metabolite Names in Biochemical Databases Used for Genome-Scale Metabolic Modelling.
PMID:30736318
SLIMEr: probing flexibility of lipid metabolism in yeast with an improved constraint-based modeling framework.
PMID:30634957
Quantitative flux coupling analysis.
PMID:30535964
Light-driven fine chemical production in yeast biohybrids.
PMID:30442806
Synthetic biology tools for engineering Yarrowia lipolytica.
PMID:30315870
Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts.
PMID:30195436
An appeal to magic? The discovery of a non-enzymatic metabolism and its role in the origins of life.
PMID:30166494
Metabolic profiling of isolated mitochondria and cytoplasm reveals compartment-specific metabolic responses.
PMID:29628813
Improving the flux distributions simulated with genome-scale metabolic models of Saccharomyces cerevisiae.
PMID:29468121
Metabolic adjustment upon repetitive substrate perturbations using dynamic 13C-tracing in yeast.
PMID:28946905
Genome-scale modeling of yeast: chronology, applications and critical perspectives.
PMID:28899034
Network analyses based on comprehensive molecular interaction maps reveal robust control structures in yeast stress response pathways.
PMID:28725465
Network reconstruction and validation of the Snf1/AMPK pathway in baker's yeast based on a comprehensive literature review.
PMID:28725459
Metabolic modeling to identify engineering targets for Komagataella phaffii: The effect of biomass composition on gene target identification.
PMID:28691262
Combining inferred regulatory and reconstructed metabolic networks enhances phenotype prediction in yeast.
PMID:28520713
Multi-omics approaches to disease.
PMID:28476144
Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine.
PMID:28396636
Constraint-based stoichiometric modelling from single organisms to microbial communities.
PMID:28334697
The Pivotal Role of Protein Phosphorylation in the Control of Yeast Central Metabolism.
PMID:28250014
Perspectives and Challenges of Microbial Application for Crop Improvement.
PMID:28232839
Spectral consensus strategy for accurate reconstruction of large biological networks.
PMID:28105915
Pathway-Consensus Approach to Metabolic Network Reconstruction for Pseudomonas putida KT2440 by Systematic Comparison of Published Models.
PMID:28085902
Systematic Analysis of Transcriptional and Post-transcriptional Regulation of Metabolism in Yeast.
PMID:28072816
A Dormant Microbial Component in the Development of Preeclampsia.
PMID:27965958
Whole-genome metabolic model of Trichoderma reesei built by comparative reconstruction.
PMID:27895706
The metabolome 18 years on: a concept comes of age.
PMID:27695392
In Vivo Analysis of NH4+ Transport and Central Nitrogen Metabolism in Saccharomyces cerevisiae during Aerobic Nitrogen-Limited Growth.
PMID:27637876
Saccharomyces cerevisiae metabolism in ecological context.
PMID:27634775
Computational Metabolomics: A Framework for the Million Metabolome.
PMID:27629808
MetMaxStruct: A Tversky-Similarity-Based Strategy for Analysing the (Sub)Structural Similarities of Drugs and Endogenous Metabolites.
PMID:27597830
The metabolic background is a global player in Saccharomyces gene expression epistasis.
PMID:27572163
Efficient Reconstruction of Predictive Consensus Metabolic Network Models.
PMID:27563720
Recon 2.2: from reconstruction to model of human metabolism.
PMID:27358602
A Bacterial Component to Alzheimer's-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease.
PMID:27340854
Reconstruction and applications of consensus yeast metabolic network based on RNA sequencing.
PMID:27239440
Mathematical Modeling and Dynamic Simulation of Metabolic Reaction Systems Using Metabolome Time Series Data.
PMID:27200361
Synthetic biology and regulatory networks: where metabolic systems biology meets control engineering.
PMID:27075000
Microbial network for waste activated sludge cascade utilization in an integrated system of microbial electrolysis and anaerobic fermentation.
PMID:27042212
A Strategy for Functional Interpretation of Metabolomic Time Series Data in Context of Metabolic Network Information.
PMID:27014700
Technology development for natural product biosynthesis in Saccharomyces cerevisiae.
PMID:26994377
libChEBI: an API for accessing the ChEBI database.
PMID:26933452
Integration and Validation of the Genome-Scale Metabolic Models of Pichia pastoris: A Comprehensive Update of Protein Glycosylation Pathways, Lipid and Energy Metabolism.
PMID:26812499
Measuring the robustness of link prediction algorithms under noisy environment.
PMID:26733156
Towards improved genome-scale metabolic network reconstructions: unification, transcript specificity and beyond.
PMID:26615025
Genome-scale modelling of microbial metabolism with temporal and spatial resolution.
PMID:26614655
Network Analysis Identifies Mitochondrial Regulation of Epidermal Differentiation by MPZL3 and FDXR.
PMID:26609959
Growth and metabolism of Beauveria bassiana spores and mycelia.
PMID:26581712
Comparative Analysis of Yeast Metabolic Network Models Highlights Progress, Opportunities for Metabolic Reconstruction.
PMID:26566239
Flux balance analysis of genome-scale metabolic model of rice (Oryza sativa): aiming to increase biomass.
PMID:26564982
Cell scale host-pathogen modeling: another branch in the evolution of constraint-based methods.
PMID:26500611
An overview of bioinformatics methods for modeling biological pathways in yeast.
PMID:26476430
ChEBI in 2016: Improved services and an expanding collection of metabolites.
PMID:26467479
Algorithms for modeling global and context-specific functional relationship networks.
PMID:26254431
Modeling cancer metabolism on a genome scale.
PMID:26130389
Many InChIs and quite some feat.
PMID:26081259
Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis.
PMID:26001086
Linking metabolomics data to underlying metabolic regulation.
PMID:25988163
Mimoza: web-based semantic zooming and navigation in metabolic networks.
PMID:25889977
Inferring causal metabolic signals that regulate the dynamic TORC1-dependent transcriptome.
PMID:25888284
Systems modeling approaches for microbial community studies: from metagenomics to inference of the community structure.
PMID:25852671
A 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs.
PMID:25750602
Genome-scale modeling for metabolic engineering.
PMID:25578304
Improving collaboration by standardization efforts in systems biology.
PMID:25538939
The virtue of innovation: innovation through the lenses of biological evolution.
PMID:25505138
Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.
PMID:25503938
Computational strategies for a system-level understanding of metabolism.
PMID:25427076
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion.
PMID:25400580
Identification of novel knockout targets for improving terpenoids biosynthesis in Saccharomyces cerevisiae.
PMID:25386654
Reconstruction of metabolic pathways by combining probabilistic graphical model-based and knowledge-based methods.
PMID:25374614
Computational analysis of reciprocal association of metabolism and epigenetics in the budding yeast: a genome-scale metabolic model (GSMM) approach.
PMID:25365344
Environmental systems biology of cold-tolerant phenotype in Saccharomyces species adapted to grow at different temperatures.
PMID:25243355
Multi-capillary column-ion mobility spectrometry of volatile metabolites emitted by Saccharomyces cerevisiae.
PMID:25197771
Sequence divergence and diversity suggests ongoing functional diversification of vertebrate NAD metabolism.
PMID:25084685
Network thermodynamic curation of human and yeast genome-scale metabolic models.
PMID:25028891
Processing biological literature with customizable Web services supporting interoperable formats.
PMID:25006225
An integrative, multi-scale, genome-wide model reveals the phenotypic landscape of Escherichia coli.
PMID:24987114
CASMI-The Small Molecule Identification Process from a Birmingham Perspective.
PMID:24957998
Human metabolic network: reconstruction, simulation, and applications in systems biology.
PMID:24957377
Event-based text mining for biology and functional genomics.
PMID:24907365
Untangling complex dynamical systems via derivative-variable correlations.
PMID:24848769
Optimizing genome-scale network reconstructions.
PMID:24811519
Importance of understanding the main metabolic regulation in response to the specific pathway mutation for metabolic engineering of Escherichia coli.
PMID:24688678
Revising the Representation of Fatty Acid, Glycerolipid, and Glycerophospholipid Metabolism in the Consensus Model of Yeast Metabolism.
PMID:24678285
Death by a thousand cuts: the challenges and diverse landscape of lignocellulosic hydrolysate inhibitors.
PMID:24672514
A future of the model organism model.
PMID:24577733
PathNER: a tool for systematic identification of biological pathway mentions in the literature.
PMID:24555844
MEMOSys 2.0: an update of the bioinformatics database for genome-scale models and genomic data.
PMID:24532766
Age-correlated stress resistance improves fitness of yeast: support from agent-based simulations.
PMID:24529069
Integration of transcription and flux data reveals molecular paths associated with differences in oxygen-dependent phenotypes of Saccharomyces cerevisiae.
PMID:24528924
Comparative genome-scale reconstruction of gapless metabolic networks for present and ancestral species.
PMID:24516375
Systematic construction of kinetic models from genome-scale metabolic networks.
PMID:24324546
Increased isobutanol production in Saccharomyces cerevisiae by eliminating competing pathways and resolving cofactor imbalance.
PMID:24305546
Path2Models: large-scale generation of computational models from biochemical pathway maps.
PMID:24180668
A novel untargeted metabolomics correlation-based network analysis incorporating human metabolic reconstructions.
PMID:24153255
In silico profiling of Escherichia coli and Saccharomyces cerevisiae as terpenoid factories.
PMID:24059635
Economic and environmental impacts of microbial biodiesel.
PMID:24022152
Analyzing LC/MS metabolic profiling data in the context of existing metabolic networks.
PMID:24010053
Version 6 of the consensus yeast metabolic network refines biochemical coverage and improves model performance.
PMID:23935056
Computational approaches for understanding energy metabolism.
PMID:23897661
Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery.
PMID:23892182
An analysis of a 'community-driven' reconstruction of the human metabolic network.
PMID:23888127
A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes.
PMID:23831062
A method for integrating and ranking the evidence for biochemical pathways by mining reactions from text.
PMID:23813008
Simple topological properties predict functional misannotations in a metabolic network.
PMID:23812979
Consensus and conflict cards for metabolic pathway databases.
PMID:23803311
Nucleotide degradation and ribose salvage in yeast.
PMID:23670538
Mapping condition-dependent regulation of metabolism in yeast through genome-scale modeling.
PMID:23631471
Genome-scale modeling enables metabolic engineering of Saccharomyces cerevisiae for succinic acid production.
PMID:23608777
The RAVEN toolbox and its use for generating a genome-scale metabolic model for Penicillium chrysogenum.
PMID:23555215
AMBIENT: Active Modules for Bipartite Networks--using high-throughput transcriptomic data to dissect metabolic response.
PMID:23531303
Sequencing and annotation of the Ophiostoma ulmi genome.
PMID:23496816
A community-driven global reconstruction of human metabolism.
PMID:23455439
Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease.
PMID:23413375
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.
PMID:23384594
MetaNetX.org: a website and repository for accessing, analysing and manipulating metabolic networks.
PMID:23357920
Industrial systems biology of Saccharomyces cerevisiae enables novel succinic acid cell factory.
PMID:23349810
Reconstruction and in silico analysis of metabolic network for an oleaginous yeast, Yarrowia lipolytica.
PMID:23236514
Exploiting genomic knowledge in optimising molecular breeding programmes: algorithms from evolutionary computing.
PMID:23185279
Multiscale modeling of metabolism and macromolecular synthesis in E. coli and its application to the evolution of codon usage.
PMID:23029152
Understanding the immune response to seasonal influenza vaccination in older adults: a systems biology approach.
PMID:23002979
Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs.
PMID:22976491
Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence.
PMID:22934043
MicrobesFlux: a web platform for drafting metabolic models from the KEGG database.
PMID:22857267
Literature retrieval and mining in bioinformatics: state of the art and challenges.
PMID:22778730
Improving metabolic flux predictions using absolute gene expression data.
PMID:22713172
The yin and yang of yeast transcription: elements of a global feedback system between metabolism and chromatin.
PMID:22685547
Identification of functional differences in metabolic networks using comparative genomics and constraint-based models.
PMID:22666308
Yeast 5 - an expanded reconstruction of the Saccharomyces cerevisiae metabolic network.
PMID:22663945
Protein Phylogenetic Analysis of Ca(2+)/cation Antiporters and Insights into their Evolution in Plants.
PMID:22645563
Production of 2,3-butanediol in Saccharomyces cerevisiae by in silico aided metabolic engineering.
PMID:22640729
A genome-scale metabolic model of the lipid-accumulating yeast Yarrowia lipolytica.
PMID:22558935
Synthetic biology: mapping the scientific landscape.
PMID:22539946
Large-scale sequestration of atmospheric carbon via plant roots in natural and agricultural ecosystems: why and how.
PMID:22527402
Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in silico evaluation of their potentials.
PMID:22472172
Scientific discovery as a combinatorial optimisation problem: how best to navigate the landscape of possible experiments?
PMID:22252984
MetRxn: a knowledgebase of metabolites and reactions spanning metabolic models and databases.
PMID:22233419
Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease.
PMID:22184244
Using the reconstructed genome-scale human metabolic network to study physiology and pathology.
PMID:22142339
A vision for a biomedical cloud.
PMID:22142244
Evolutionary significance of metabolic network properties.
PMID:22130553
YMDB: the Yeast Metabolome Database.
PMID:22064855
Software for systems biology: from tools to integrated platforms.
PMID:22048662
Chemical basis of metabolic network organization.
PMID:22022254
Critical assessment of human metabolic pathway databases: a stepping stone for future integration.
PMID:21999653
Whole-genome metabolic network reconstruction and constraint-based modeling.
PMID:21943909
Engineering strategy of yeast metabolism for higher alcohol production.
PMID:21902829
Integrating systems biology models and biomedical ontologies.
PMID:21835028
Synergies between synthetic biology and metabolic engineering.
PMID:21822239
Retrieval, alignment, and clustering of computational models based on semantic annotations.
PMID:21772260
Mining metabolites: extracting the yeast metabolome from the literature.
PMID:21687783
Social engineering for virtual 'big science' in systems biology.
PMID:21587248
Extending biochemical databases by metabolomic surveys.
PMID:21566124
Unpredictability of metabolism--the key role of metabolomics science in combination with next-generation genome sequencing.
PMID:21556754
The strength of chemical linkage as a criterion for pruning metabolic graphs.
PMID:21551141
Reconciliation of genome-scale metabolic reconstructions for comparative systems analysis.
PMID:21483480
Mass-balanced randomization of metabolic networks.
PMID:21436128
Customizable views on semantically integrated networks for systems biology.
PMID:21414991
Comprehensive quantitative analysis of central carbon and amino-acid metabolism in Saccharomyces cerevisiae under multiple conditions by targeted proteomics.
PMID:21283140
MEMOSys: Bioinformatics platform for genome-scale metabolic models.
PMID:21276275
Genome-scale reconstruction of metabolic network for a halophilic extremophile, Chromohalobacter salexigens DSM 3043.
PMID:21251315
A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2.
PMID:21244678
Improving the iMM904 S. cerevisiae metabolic model using essentiality and synthetic lethality data.
PMID:21190580
Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications.
PMID:21176163
In situ to in silico and back: elucidating the physiology and ecology of Geobacter spp. using genome-scale modelling.
PMID:21132020
Environments that induce synthetic microbial ecosystems.
PMID:21124952
Software that goes with the flow in systems biology.
PMID:21114874
Systematic integration of experimental data and models in systems biology.
PMID:21114840
Parameter balancing in kinetic models of cell metabolism.
PMID:21038890
Extensive in vivo metabolite-protein interactions revealed by large-scale systematic analyses.
PMID:21035178
Further developments towards a genome-scale metabolic model of yeast.
PMID:21029416
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.
PMID:20967426
A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1.
PMID:20959003
Quantitative analysis of cellular metabolic dissipative, self-organized structures.
PMID:20957111
A compartmental model analysis of integrative and self-regulatory ion dynamics in pollen tube growth.
PMID:20949135
Investigating the validity of current network analysis on static conglomerate networks by protein network stratification.
PMID:20846443
In silico models of cancer.
PMID:20836040
Towards whole-body systems physiology.
PMID:20823847
Integration of metabolic databases for the reconstruction of genome-scale metabolic networks.
PMID:20712863
The metabolic network of Synechocystis sp. PCC 6803: systemic properties of autotrophic growth.
PMID:20616194
Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways.
PMID:20567500
PathText: a text mining integrator for biological pathway visualizations.
PMID:20529930
IGERS: inferring Gibbs energy changes of biochemical reactions from reaction similarities.
PMID:20513391
Reconstruction of the yeast protein-protein interaction network involved in nutrient sensing and global metabolic regulation.
PMID:20500839
Reconstruction and validation of RefRec: a global model for the yeast molecular interaction network.
PMID:20498836
Nutrient control of eukaryote cell growth: a systems biology study in yeast.
PMID:20497545
BioMet Toolbox: genome-wide analysis of metabolism.
PMID:20483918
Dynamic transcriptional and metabolic responses in yeast adapting to temperature stress.
PMID:20450442
BiGG: a Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions.
PMID:20426874
Reconstruction annotation jamborees: a community approach to systems biology.
PMID:20393581
How to understand the cell by breaking it: network analysis of gene perturbation screens.
PMID:20195495
Towards genome-scale signalling network reconstructions.
PMID:20177425
Systems metabolic engineering: genome-scale models and beyond.
PMID:20151446
Towards a genome-scale kinetic model of cellular metabolism.
PMID:20109182
Accomplishments in genome-scale in silico modeling for industrial and medical biotechnology.
PMID:19946878
Calling International Rescue: knowledge lost in literature and data landslide!
PMID:19929850
Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations.
PMID:19889834
Applications of genome-scale metabolic reconstructions.
PMID:19888215
Evolution of biomolecular networks: lessons from metabolic and protein interactions.
PMID:19851337
Metabolite and reaction inference based on enzyme specificities.
PMID:19696044
Assessing the impact of transcriptomics, proteomics and metabolomics on fungal phytopathology.
PMID:19694958
Pathway databases and tools for their exploitation: benefits, current limitations and challenges.
PMID:19638971
Metabolite signal identification in accurate mass metabolomics data with MZedDB, an interactive m/z annotation tool utilising predicted ionisation behaviour 'rules'.
PMID:19622150
Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae.
PMID:19607691
libAnnotationSBML: a library for exploiting SBML annotations.
PMID:19561017
(13)C-based metabolic flux analysis.
PMID:19478804
Connecting extracellular metabolomic measurements to intracellular flux states in yeast.
PMID:19321003
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.
PMID:19133145