Structural Biology Data Grid
Names
More detailed information about this field from each metasource.
Structural Biology Data Grid
metasource: Fairsharing.org
version: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: re3data.org
version: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
SBGrid-DG
metasource: Fairsharing.org
version: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
SBGrid Data Bank
metasource: re3data.org
version: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
Names
More detailed information about this field from each metasource.
Structural Biology Data Grid
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: re3data.org
version: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
SBGrid-DG
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
SBGrid Data Bank
metasource: re3data.orgversion: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
Other names: SBGrid-DG, SBGrid Data Bank
Names
More detailed information about this field from each metasource.
Structural Biology Data Grid
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: re3data.org
version: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
SBGrid-DG
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
SBGrid Data Bank
metasource: re3data.orgversion: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
The Structural Biology Data Grid (SBGrid-DG) community-driven repository to preserve primary experimental datasets that support scientific publications. The SBGrid Data Bank is an open source research data management system enabling Structural Biologists to preserve x-ray diffraction data and to make it accessible to the broad research community.
Description
More detailed information about this field from each metasource.
The Structural Biology Data Grid (SBGrid-DG) community-driven repository to preserve primary experimental datasets that support scientific publications. The SBGrid Data Bank is an open source research data management system enabling Structural Biologists to preserve x-ray diffraction data and to make it accessible to the broad research community.
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Open access to macromolecular X-ray diffraction and MicroED datasets. The repository complements the Worldwide Protein Data Bank. SBDG also hosts reference collection of biomedical datasets contributed by members of SBGrid, Harvard and pilot communities.
metasource: re3data.orgversion: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
Webpage:
http://data.sbgrid.orgWebpage
More detailed information about this field from each metasource.
http://data.sbgrid.org
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
https://data.sbgrid.org/
metasource: re3data.orgversion: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
Licence:
Name: Creative Commons CC0 1.0 Universal (CC0 1.0) Public Domain DedicationLicence name
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Creative Commons CC0 1.0 Universal (CC0 1.0) Public Domain Dedication
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
CC0
metasource: re3data.orgversion: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
Licence URL
More detailed information about this field from each metasource.
https://creativecommons.org/publicdomain/zero/1.0/
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
https://creativecommons.org/share-your-work/public-domain/cc0
metasource: re3data.orgversion: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
Publications:
Publications
More detailed information about this field from each metasource.
Collaboration gets the most out of software
PMID: 24040512
metasource: Fairsharing.org
version: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
Publications
More detailed information about this field from each metasource.
Collaboration gets the most out of software
PMID: 24040512
metasource: Fairsharing.org
version: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
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Collaboration gets the most out of software
PubMed citations: 455.
455 articles citing: Collaboration gets the most out of software
Yeast PI31 inhibits the proteasome by a direct multisite mechanism. PMID:35927584
Mechanism of client selection by the protein quality-control factor UBE2O. PMID:35915257
Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors. PMID:35908109
Akkermansia muciniphila phospholipid induces homeostatic immune responses. PMID:35896748
The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven mechanism. PMID:35802751
Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2. PMID:35794891
A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel. PMID:35768507
A surface pocket in the cytoplasmic domain of the herpes simplex virus fusogen gB controls membrane fusion. PMID:35767585
Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation. PMID:35733252
Direct interaction of a chaperone-bound type III secretion substrate with the export gate. PMID:35654781
Pentameric assembly of the Kv2.1 tetramerization domain. PMID:35647925
Structural rearrangements allow nucleic acid discrimination by type I-D Cascade. PMID:35595728
Ciliary central apparatus structure reveals mechanisms of microtubule patterning. PMID:35578023
Structure of a TRAPPII-Rab11 activation intermediate reveals GTPase substrate selection mechanisms. PMID:35559680
Molecular architecture of the human caveolin-1 complex. PMID:35544577
Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. PMID:35534503
In crystallo observation of three metal ion promoted DNA polymerase misincorporation. PMID:35487947
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern. PMID:35471062
Structural Insight into KsBcl-2 Mediated Apoptosis Inhibition by Kaposi Sarcoma Associated Herpes Virus. PMID:35458468
Structural and functional impact by SARS-CoV-2 Omicron spike mutations. PMID:35452593
Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity. PMID:35446253
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer. PMID:35422503
Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. PMID:35388215
Structures of Tetrahymena's respiratory chain reveal the diversity of eukaryotic core metabolism. PMID:35357889
Structural and mechanistic basis for redox sensing by the cyanobacterial transcription regulator RexT. PMID:35347217
pH regulates potassium conductance and drives a constitutive proton current in human TMEM175. PMID:35333573
Design of protein-binding proteins from the target structure alone. PMID:35332283
Facile discovery of surrogate cytokine agonists. PMID:35325595
Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19. PMID:35314834
Structural mechanism of muscle nicotinic receptor desensitization and block by curare. PMID:35301478
Structural basis for activation and gating of IP3 receptors. PMID:35301323
The Structure of the Arabidopsis PEX4-PEX22 Peroxin Complex-Insights Into Ubiquitination at the Peroxisomal Membrane. PMID:35300425
Interleukin-2 superkines by computational design. PMID:35294290
Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins. PMID:35288548
Visualizing the gas channel of a monofunctional carbon monoxide dehydrogenase. PMID:35278753
Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies. PMID:35275718
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. PMID:35260847
XFEL serial crystallography reveals the room temperature structure of methyl-coenzyme M reductase. PMID:35202981
Visualizing protein breathing motions associated with aromatic ring flipping. PMID:35173330
The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature. PMID:35169801
An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking. PMID:35136165
Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation. PMID:35121834
Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats. PMID:35023832
Design principles for site-selective hydroxylation by a Rieske oxygenase. PMID:35017498
Protection of the Prodomain α1-Helix Correlates with Latency in the Transforming Growth Factor-β Family. PMID:34990654
The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina. PMID:34981769
Effects of chameleon dispense-to-plunge speed on particle concentration, complex formation, and final resolution: A case study using the Neisseria gonorrhoeae ribonucleotide reductase inactive complex. PMID:34906669
Structural insights into metazoan pretargeting GET complexes. PMID:34887561
NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation. PMID:34861190
Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates. PMID:34850944
ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals. PMID:34821552
Structural basis for ligand reception by anaplastic lymphoma kinase. PMID:34819665
Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site. PMID:34739841
De novo identification of mammalian ciliary motility proteins using cryo-EM. PMID:34715025
The conformational cycle of prestin underlies outer-hair cell electromotility. PMID:34695838
High Resolution Structure of the Mature Capsid of Ralstonia solanacearum Bacteriophage ϕRSA1 by Cryo-Electron Microscopy. PMID:34681713
Structural evidence for visual arrestin priming via complexation of phosphoinositols. PMID:34678158
The structural basis of PTEN regulation by multi-site phosphorylation. PMID:34625746
Structural characterization of DynU16, a START/Bet v1-like protein involved in dynemicin biosynthesis. PMID:34605436
Structural basis and regulation of the reductive stress response. PMID:34562363
The hypervariable region of atlastin-1 is a site for intrinsic and extrinsic regulation. PMID:34546351
Functional Properties of Oligomeric and Monomeric Forms of Helicobacter pylori VacA Toxin. PMID:34543122
Structural characterization of NrnC identifies unifying features of dinucleotidases. PMID:34533457
Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens. PMID:34489470
Shape-Restrained Modeling of Protein-Small-Molecule Complexes with High Ambiguity Driven DOCKing. PMID:34436890
Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC. PMID:34429416
Targeted Degradation of the Oncogenic Phosphatase SHP2. PMID:34411482
Insights into the bilayer-mediated toppling mechanism of a folate-specific ECF transporter by cryo-EM. PMID:34408021
Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk. PMID:34372579
A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. PMID:34337560
Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. PMID:34314700
Disabling the Nuclear Translocalization of RelA/NF-κB by a Small Molecule Inhibits Triple-Negative Breast Cancer Growth. PMID:34262338
Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. PMID:34171296
Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. PMID:34168070
Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease. PMID:34161756
Divergent evolution toward sex chromosome-specific gene regulation in Drosophila. PMID:34140353
Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers. PMID:34135340
Crystal Structure of the [4Fe-4S] Cluster-Containing Adenosine-5'-phosphosulfate Reductase from Mycobacterium tuberculosis. PMID:34095667
Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer. PMID:34050170
Acute pharmacological degradation of Helios destabilizes regulatory T cells. PMID:34035522
Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. PMID:34019797
Structural basis of TRAPPIII-mediated Rab1 activation. PMID:34018207
iPick: Multiprocessing software for integrated NMR signal detection and validation. PMID:34004411
Bipartite binding of the N terminus of Skp2 to cyclin A. PMID:33989513
Making the invisible enemy visible. PMID:33972785
A PyMOL snippet library for Jupyter to boost researcher productivity. PMID:33967632
Cryo-EM structure of a thermostable bacterial nanocompartment. PMID:33953921
Structural biology in the time of COVID-19: perspectives on methods and milestones. PMID:33953920
The Protein Data Bank Archive. PMID:33950382
Familial Autonomic Ganglionopathy Caused by Rare CHRNA3 Genetic Variants. PMID:33947782
Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19. PMID:33907749
Transferrin receptor targeting by de novo sheet extension. PMID:33879614
Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis. PMID:33875834
Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies. PMID:33871352
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. PMID:33853786
The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design. PMID:33852830
Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis. PMID:33846632
Structural basis for the initiation of COPII vesicle biogenesis. PMID:33831355
Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses. PMID:33823129
Experimental evaluation of super-resolution imaging and magnification choice in single-particle cryo-EM. PMID:33817625
The Modern Research Data Portal: a design pattern for networked, data-intensive science. PMID:33816800
Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase. PMID:33773110
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. PMID:33735609
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. PMID:33731932
Structural impact on SARS-CoV-2 spike protein by D614G substitution. PMID:33727252
Structural basis of the human Scribble-Vangl2 association in health and disease. PMID:33684218
An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation. PMID:33675849
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. PMID:33636189
Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain. PMID:33627480
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. PMID:33608534
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. PMID:33606986
Eltrombopag directly inhibits BAX and prevents cell death. PMID:33602934
Structural basis for transcription complex disruption by the Mfd translocase. PMID:33480355
Structure of a microtubule-bound axonemal dynein. PMID:33473120
Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants. PMID:33463523
Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81. PMID:33446559
Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity. PMID:33444025
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent. PMID:33432247
Structures of radial spokes and associated complexes important for ciliary motility. PMID:33318703
A nanobody suite for yeast scaffold nucleoporins provides details of the nuclear pore complex structure. PMID:33268786
Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. PMID:33253191
Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11. PMID:33253113
Yeast Nup84-Nup133 complex structure details flexibility and reveals conservation of the membrane anchoring ALPS motif. PMID:33247142
Mechanism of Lamellar Body Formation by Lung Surfactant Protein B. PMID:33242393
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. PMID:33236988
Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA. PMID:33208376
Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs. PMID:33184270
Crystal structures of ORFV125 provide insight into orf virus-mediated inhibition of apoptosis. PMID:33175095
Bringing the Heavy Chain to Light: Creating a Symmetric, Bivalent IgG-Like Bispecific. PMID:33172091
Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization. PMID:33168989
A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms. PMID:33122192
Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance. PMID:33096918
Topaz-Denoise: general deep denoising models for cryoEM and cryoET. PMID:33060581
"The structure of the Type III secretion system export gate with CdsO, an ATPase lever arm". PMID:33048983
Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. PMID:33033255
Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro. PMID:33033190
Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis. PMID:32998881
Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate. PMID:32997730
Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase. PMID:32937101
Structural basis of αE-catenin-F-actin catch bond behavior. PMID:32915141
Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase. PMID:32902386
The Structure of the Cysteine-Rich Domain of Plasmodium falciparum P113 Identifies the Location of the RH5 Binding Site. PMID:32900802
Shared structural mechanisms of general anaesthetics and benzodiazepines. PMID:32879488
An autoinhibitory role for the GRF zinc finger domain of DNA glycosylase NEIL3. PMID:32878989
Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex. PMID:32876048
Inhibitors of BRAF dimers using an allosteric site. PMID:32873792
The cryoelectron microscopy structure of the human CDK-activating kinase. PMID:32855301
Atomic structure of a mitochondrial complex I intermediate from vascular plants. PMID:32840211
Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM. PMID:32832689
An ER translocon for multi-pass membrane protein biogenesis. PMID:32820719
A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers. PMID:32817551
Structural basis for dimerization quality control. PMID:32814905
Phenotypic Profiling in Subjects Heterozygous for 1 of 2 Rare Variants in the Hypophosphatasia Gene (ALPL). PMID:32803091
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. PMID:32783916
The structural basis of Bcl-2 mediated cell death regulation in hydra. PMID:32776134
Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step. PMID:32745149
Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. PMID:32697994
Distinct conformational states of SARS-CoV-2 spike protein. PMID:32694201
Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex. PMID:32676607
The Solvent-Exposed Fe-S D-Cluster Contributes to Oxygen-Resistance in Desulfovibrio vulgaris Ni-Fe Carbon Monoxide Dehydrogenase. PMID:32655979
Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site. PMID:32643196
Structure of human GABAB receptor in an inactive state. PMID:32581365
Structural basis for divergent C-H hydroxylation selectivity in two Rieske oxygenases. PMID:32532989
Structure of a nascent membrane protein as it folds on the BAM complex. PMID:32528179
Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes. PMID:32518066
Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation. PMID:32511295
Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs. PMID:32451496
Prochlorococcus phage ferredoxin: structural characterization and electron transfer to cyanobacterial sulfite reductases. PMID:32434930
A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM. PMID:32424347
Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance. PMID:32415166
Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation. PMID:32415073
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies. PMID:32375025
Conserved Outer Tegument Component UL11 from Herpes Simplex Virus 1 Is an Intrinsically Disordered, RNA-Binding Protein. PMID:32371601
Tubulin Resists Degradation by Cereblon-Recruiting PROTACs. PMID:32349222
A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. PMID:32338599
Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends. PMID:32313946
Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction. PMID:32297861
Membrane constriction and thinning by sequential ESCRT-III polymerization. PMID:32251413
Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers. PMID:32234486
Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. PMID:32221310
Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex. PMID:32217749
Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme. PMID:32180548
Stepwise Promoter Melting by Bacterial RNA Polymerase. PMID:32160514
Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. PMID:32152588
Diffuse X-ray scattering from correlated motions in a protein crystal. PMID:32152274
Structural elucidation of the Clostridioides difficile transferase toxin reveals a single-site binding mode for the enzyme. PMID:32123082
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. PMID:32075877
The evolution of SPHIRE-crYOLO particle picking and its application in automated cryo-EM processing workflows. PMID:32047248
Development of a covalent inhibitor of gut bacterial bile salt hydrolases. PMID:32042200
Human PLD structures enable drug design and characterization of isoenzyme selectivity. PMID:32042197
Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement. PMID:31995732
iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates. PMID:31988461
Structure and activation mechanism of the BBSome membrane protein trafficking complex. PMID:31939736
Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist. PMID:31915246
Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. PMID:31891593
Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement. PMID:31886770
Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS. PMID:31880537
A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae. PMID:31796544
In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls. PMID:31748512
Structural and Biochemical Investigations of the [4Fe-4S] Cluster-Containing Fumarate Hydratase from Leishmania major. PMID:31743022
Development and Characterization of a Wee1 Kinase Degrader. PMID:31735695
Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore. PMID:31712627
PDBe: improved findability of macromolecular structure data in the PDB. PMID:31691821
Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. PMID:31690634
An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation. PMID:31690625
Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01. PMID:31653484
Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. PMID:31634471
MARTINI-Based Protein-DNA Coarse-Grained HADDOCKing. PMID:31632986
KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. PMID:31611389
Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs. PMID:31591578
Structure of an RNA helix with pyrimidine mismatches and cross-strand stacking. PMID:31584014
Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. PMID:31581174
Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25. PMID:31551421
Less Is More: Coarse-Grained Integrative Modeling of Large Biomolecular Assemblies with HADDOCK. PMID:31539250
Regulation of Eag1 gating by its intracellular domains. PMID:31490124
Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor. PMID:31488329
Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme. PMID:31478652
Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin. PMID:31461953
Combining Mutations That Inhibit Two Distinct Steps of the ATP Hydrolysis Cycle Restores Wild-Type Function in the Lipopolysaccharide Transporter and Shows that ATP Binding Triggers Transport. PMID:31431556
Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-α-1,4-galactosaminidase that disrupts microbial biofilms. PMID:31416836
Protein crystal structure determination with the crystallophore, a nucleating and phasing agent. PMID:31396026
A strategy for the selection of monovalent antibodies that span protein dimer interfaces. PMID:31387945
A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2. PMID:31366933
Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA. PMID:31348888
Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. PMID:31324887
The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation. PMID:31316802
Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine. PMID:31301259
Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase. PMID:31296570
X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate. PMID:31239351
Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link. PMID:31235915
A dedicated diribonucleotidase resolves a key bottleneck for the terminal step of RNA degradation. PMID:31225796
Structure of the Helicobacter pylori Cag type IV secretion system. PMID:31210639
High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations. PMID:31182604
Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases. PMID:31167793
Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP. PMID:31133752
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. PMID:31123111
Fusion of DARPin to Aldolase Enables Visualization of Small Protein by Cryo-EM. PMID:31080120
Transient opening of trimeric prefusion RSV F proteins. PMID:31068578
FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane. PMID:31056421
High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers. PMID:31048915
Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV. PMID:31034849
Structural basis for auxiliary subunit KCTD16 regulation of the GABAB receptor. PMID:30971491
Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization. PMID:30954575
Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+ /calmodulin-dependent protein kinase II. PMID:30942928
Substrate specificity of the pyrophosphohydrolase LpxH determines the asymmetry of Bordetella pertussis lipid A. PMID:30926608
A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins. PMID:30850593
A widely distributed diheme enzyme from Burkholderia that displays an atypically stable bis-Fe(IV) state. PMID:30846684
Challenge data set for macromolecular multi-microcrystallography. PMID:30821701
Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters. PMID:30729188
Small-molecule allosteric inhibitors of BAX. PMID:30718816
Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter. PMID:30714568
pdb-tools: a swiss army knife for molecular structures. PMID:30705752
Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network. PMID:30645119
Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate. PMID:30645090
Structure of the post-translational protein translocation machinery of the ER membrane. PMID:30644436
Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. PMID:30626968
Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. PMID:30626643
Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides. PMID:30606802
Natural helix 9 mutants of PPARγ differently affect its transcriptional activity. PMID:30595551
Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy. PMID:30575723
Functional and structural similarity of human DNA primase [4Fe4S] cluster domain constructs. PMID:30562384
The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains. PMID:30525509
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. PMID:30478421
iSEE: Interface structure, evolution, and energy-based machine learning predictor of binding affinity changes upon mutations. PMID:30417935
Structural basis for the second step of group II intron splicing. PMID:30410046
Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45. PMID:30367064
Protein Data Bank: the single global archive for 3D macromolecular structure data. PMID:30357364
YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria. PMID:30355735
Structures of translationally inactive mammalian ribosomes. PMID:30355441
Noncanonical role for the binding protein in substrate uptake by the MetNI methionine ATP Binding Cassette (ABC) transporter. PMID:30352853
Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity. PMID:30341796
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. PMID:30297823
Structural basis for σ1 receptor ligand recognition. PMID:30291362
RIP2 filament formation is required for NOD2 dependent NF-κB signalling. PMID:30279485
Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase. PMID:30277213
A structural investigation of NRZ mediated apoptosis regulation in zebrafish. PMID:30237469
Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase. PMID:30217813
Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development. PMID:30197299
Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor. PMID:30197297
The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a PseudoGTPase. PMID:30174148
The dynamic nature of the conserved tegument protein UL37 of herpesviruses. PMID:30166339
An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice. PMID:30144430
Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating. PMID:30139744
Protein-ligand pose and affinity prediction: Lessons from D3R Grand Challenge 3. PMID:30128928
Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition. PMID:30082428
Structure of the monotopic membrane protein (S)-mandelate dehydrogenase at 2.2 Å resolution. PMID:30071260
Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability. PMID:30051891
Human β-defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization. PMID:30050988
Crystal Structure of an Unusual Single-Stranded DNA-Binding Protein Encoded by Staphylococcal Cassette Chromosome Elements. PMID:30017563
Structural basis for the regulation of inositol trisphosphate receptors by Ca2+ and IP3. PMID:30013099
SIMBAD: a sequence-independent molecular-replacement pipeline. PMID:29968670
Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4. PMID:29967539
Structure of a human synaptic GABAA receptor. PMID:29950725
Plasticity in binding confers selectivity in ligand-induced protein degradation. PMID:29892083
Structural Basis for Transcript Elongation Control by NusG Family Universal Regulators. PMID:29887376
Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy. PMID:29882741
Inhibitors of the HIV-1 capsid, a target of opportunity. PMID:29782334
X-ray structure of a carpet-like antimicrobial defensin-phospholipid membrane disruption complex. PMID:29773800
Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. PMID:29760382
Cryo-EM structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6 (TRPC6). PMID:29752403
Structural basis for membrane anchoring and fusion regulation of the herpes simplex virus fusogen gB. PMID:29728654
Structural principles of distinct assemblies of the human α4β2 nicotinic receptor. PMID:29720657
PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms. PMID:29684093
Molecular Basis of Unusually High Neutralization Resistance in Tier 3 HIV-1 Strain 253-11. PMID:29618644
Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis. PMID:29590088
Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel. PMID:29562233
Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies. PMID:29509814
In silico and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency. PMID:29487133
Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts. PMID:29480804
Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii. PMID:29462788
Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. PMID:29396163
Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large. PMID:29378849
Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGFβ1 antibody. PMID:29333938
Robo1 Forms a Compact Dimer-of-Dimers Assembly. PMID:29307485
Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. PMID:29300467
High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions. PMID:29300389
CDC42 binds PAK4 via an extended GTPase-effector interface. PMID:29295922
Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors. PMID:29276036
Structure-based membrane dome mechanism for Piezo mechanosensitivity. PMID:29231809
Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10. PMID:29224781
Structural basis for methylphosphonate biosynthesis. PMID:29217579
The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion. PMID:29216315
Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies. PMID:29195810
Biochemical and structural characterization of a novel cooperative binding mode by Pit-1 with CATT repeats in the macrophage migration inhibitory factor promoter. PMID:29186613
A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core. PMID:29180453
A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells. PMID:29180448
Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria. PMID:29149595
Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25. PMID:29146922
PDBe: towards reusable data delivery infrastructure at protein data bank in Europe. PMID:29126160
Assessment of contact predictions in CASP12: Co-evolution and deep learning coming of age. PMID:29071738
Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX. PMID:29061852
Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC. PMID:29054852
Structural and Functional Insight into Canarypox Virus CNP058 Mediated Regulation of Apoptosis. PMID:29053589
Molecular basis for inner kinetochore configuration through RWD domain-peptide interactions. PMID:29046335
PAK4 crystal structures suggest unusual kinase conformational movements. PMID:28993291
Bacillus anthracis Prolyl 4-Hydroxylase Interacts with and Modifies Elongation Factor Tu. PMID:28981257
PelA and PelB proteins form a modification and secretion complex essential for Pel polysaccharide-dependent biofilm formation in Pseudomonas aeruginosa. PMID:28972168
Molecular basis of human CD22 function and therapeutic targeting. PMID:28970495
p190RhoGAP proteins contain pseudoGTPase domains. PMID:28894085
Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography. PMID:28827354
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen. PMID:28807998
Crystal Structure of the N-Terminal Half of the Traffic Controller UL37 from Herpes Simplex Virus 1. PMID:28768862
Novel function of a dynein light chain in actin assembly during clathrin-mediated endocytosis. PMID:28706108
Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface. PMID:28705932
Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures. PMID:28703128
Deconstruction of the Ras switching cycle through saturation mutagenesis. PMID:28686159
Timing and Reset Mechanism of GTP Hydrolysis-Driven Conformational Changes of Atlastin. PMID:28602821
Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae. PMID:28592490
Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome. PMID:28575668
Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A. PMID:28561733
Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1. PMID:28475873
NMRbox: A Resource for Biomolecular NMR Computation. PMID:28445744
Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding. PMID:28425466
Structural basis of apoptosis inhibition by the fowlpox virus protein FPV039. PMID:28411240
Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication. PMID:28396572
Structure of a DNA glycosylase that unhooks interstrand cross-links. PMID:28396405
Beyond Fourier. PMID:28385517
Crystal structure and RNA-binding properties of an Hfq homolog from the deep-branching Aquificae: conservation of the lateral RNA-binding mode. PMID:28375142
A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis. PMID:28346939
Structural insights into adiponectin receptors suggest ceramidase activity. PMID:28329765
Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope. PMID:28250417
Oligomeric lipoprotein PelC guides Pel polysaccharide export across the outer membrane of Pseudomonas aeruginosa. PMID:28242707
Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis. PMID:28223502
Structural and Preclinical Studies of Computationally Designed Non-Nucleoside Reverse Transcriptase Inhibitors for Treating HIV infection. PMID:28167742
Structural Titration of Slo2.2, a Na+-Dependent K+ Channel. PMID:28111072
Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex. PMID:28092367
Structural insight into an evolutionarily ancient programmed cell death regulator - the crystal structure of marine sponge BHP2 bound to LB-Bak-2. PMID:28079890
Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA. PMID:28067618
Structural Insight into African Swine Fever Virus A179L-Mediated Inhibition of Apoptosis. PMID:28053104
Rapid PD-L1 detection in tumors with PET using a highly specific peptide. PMID:28025143
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms. PMID:27995897
Structural basis for gating the high-conductance Ca2+-activated K+ channel. PMID:27974801
Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel. PMID:27974795
Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action. PMID:27938660
Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins. PMID:27929061
Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. PMID:27881302
Extension of research data repository system to support direct compute access to biomedical datasets: enhancing Dataverse to support large datasets. PMID:27862010
An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis. PMID:27849620
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ. PMID:27791178
Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator. PMID:27742839
Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4. PMID:27710939
X-ray structure of the human α4β2 nicotinic receptor. PMID:27698419
The apo-structure of the leucine sensor Sestrin2 is still elusive. PMID:27649739
Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization. PMID:27647905
Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant. PMID:27618663
How the glycosyltransferase OGT catalyzes amide bond cleavage. PMID:27618188
The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σV Activation. PMID:27602573
Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes. PMID:27563068
Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism. PMID:27516594
Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia. PMID:27490483
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1. PMID:27487210
Fusion to a homo-oligomeric scaffold allows cryo-EM analysis of a small protein. PMID:27485862
Structural mechanism of ligand activation in human calcium-sensing receptor. PMID:27434672
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. PMID:27373337
First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes. PMID:27369736
Competition between Coiled-Coil Structures and the Impact on Myosin-10 Bundle Selection. PMID:27276269
Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example. PMID:27276098
New Insight into the Catalytic Mechanism of Bacterial MraY from Enzyme Kinetics and Docking Studies. PMID:27226570
Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein. PMID:27194724
The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones. PMID:27138431
Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in Vivo. PMID:27137934
Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA. PMID:27105075
Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice. PMID:27089515
Crystal structure of the flagellar accessory protein FlaH of Methanocaldococcus jannaschii suggests a regulatory role in archaeal flagellum assembly. PMID:27060465
Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21. PMID:27053559
Crystal structure of the human σ1 receptor. PMID:27042935
i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4. PMID:27036939
Observing cellulose biosynthesis and membrane translocation in crystallo. PMID:26958837
Crystal structure of a substrate-engaged SecY protein-translocation channel. PMID:26950603
Data publication with the structural biology data grid supports live analysis. PMID:26947396
Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. PMID:26884191
New insights into the mechanism of substrates trafficking in Glyoxylate/Hydroxypyruvate reductases. PMID:26865263
Tuned by metals: the TET peptidase activity is controlled by 3 metal binding sites. PMID:26853450
Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha. PMID:26744780
Structural Biology: A Century-long Journey into an Unseen World. PMID:26740732
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. PMID:26586190
Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site. PMID:26565029
Structural basis of membrane budding by the nuclear egress complex of herpesviruses. PMID:26511020
Crystal Structure of the Human Cytomegalovirus Glycoprotein B. PMID:26484870
Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel. PMID:26436452
Characterization of the Pseudomonas aeruginosa Glycoside Hydrolase PslG Reveals That Its Levels Are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation. PMID:26424791
Structural basis for gene regulation by a B12-dependent photoreceptor. PMID:26416754
Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan in Aspergillus fumigatus. PMID:26342082
Structural Basis for Substrate Specificity in Adenosylcobalamin-dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases. PMID:26318610
Allosteric activation of apicomplexan calcium-dependent protein kinases. PMID:26305940
Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. PMID:26235885
The protein BpsB is a poly-β-1,6-N-acetyl-D-glucosamine deacetylase required for biofilm formation in Bordetella bronchiseptica. PMID:26203190
Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen. PMID:26124143
Structural Characterization of Bardet-Biedl Syndrome 9 Protein (BBS9). PMID:26085087
Protein Crystallography in Vaccine Research and Development. PMID:26068237
Conformational Changes of the Clamp of the Protein Translocation ATPase SecA. PMID:25982945
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. PMID:25918846
A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. PMID:25909780
The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation. PMID:25849390
Atomic structure of the Y complex of the nuclear pore. PMID:25822992
Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim. PMID:25766319
Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis. PMID:25597447
Structural basis for the disruption of the cerebral cavernous malformations 2 (CCM2) interaction with Krev interaction trapped 1 (KRIT1) by disease-associated mutations. PMID:25525273
Distinct N-terminal regions of the exomer secretory vesicle cargo Chs3 regulate its trafficking itinerary. PMID:25364754
Structural basis for the De-N-acetylation of Poly-β-1,6-N-acetyl-D-glucosamine in Gram-positive bacteria. PMID:25359777
Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases. PMID:25320316
Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins. PMID:25253889
Crystal structure of a eukaryotic group II intron lariat. PMID:25252982
Crystallographic evidence of drastic conformational changes in the active site of a flavin-dependent N-hydroxylase. PMID:25184411
Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP. PMID:25182848
How lamina-associated polypeptide 1 (LAP1) activates Torsin. PMID:25149450
Structural determinants for binding of sorting nexin 17 (SNX17) to the cytoplasmic adaptor protein Krev interaction trapped 1 (KRIT1). PMID:25059659
Structural insight into BH3 domain binding of vaccinia virus antiapoptotic F1L. PMID:24850748
Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP. PMID:24704788
Phosphoinositide-mediated oligomerization of a defensin induces cell lysis. PMID:24692446
Purification, crystallization and preliminary X-ray diffraction of the N-terminal calmodulin-like domain of the human mitochondrial ATP-Mg/Pi carrier SCaMC1. PMID:24419621
HCF-1 is cleaved in the active site of O-GlcNAc transferase. PMID:24311690
Structural mechanism of ligand activation in human GABA(B) receptor. PMID:24305054
Molecular structure of the Brucella abortus metalloprotein RicA, a Rab2-binding virulence effector. PMID:24251537
Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6. PMID:24204982
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version: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
imaging
metasource: Fairsharing.org
version: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
light microscopy
metasource: Fairsharing.org
version: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
light-sheet illumination
metasource: Fairsharing.org
version: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
molecular structure
metasource: Fairsharing.org
version: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
protein
metasource: Fairsharing.org
version: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
structure
metasource: Fairsharing.org
version: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
x-ray diffraction
metasource: Fairsharing.org
version: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: re3data.org
version: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
x-ray crystallography
metasource: re3data.org
version: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
macromolecular models
metasource: re3data.org
version: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
nuclear magnetic resonance
metasource: re3data.org
version: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
structural biology
metasource: re3data.org
version: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
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More detailed information about this field from each metasource.
centrally registered identifier
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
imaging
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
light microscopy
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
light-sheet illumination
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
molecular structure
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
protein
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
structure
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
x-ray diffraction
metasource: Fairsharing.orgversion: FAIRsharing.org: SBGrid-DG; Structural Biology Data Grid; DOI: https://doi.org/10.25504/FAIRsharing.1hqd55; Last edited: March 17, 2021, 2:12 p.m.; Last accessed: Jan 03 2022 7:06 p.m.
metasource: re3data.org
version: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
x-ray crystallography
metasource: re3data.orgversion: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
macromolecular models
metasource: re3data.orgversion: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
nuclear magnetic resonance
metasource: re3data.orgversion: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
structural biology
metasource: re3data.orgversion: re3data.org: Structural Biology Data Grid; editing status 2019-01-17; re3data.org - Registry of Research Data Repositories. http://doi.org/10.17616/R3N92J last accessed: 2022-11-04
centrally registered identifier imaging light microscopy light-sheet illumination molecular structure protein structure x-ray diffraction x-ray crystallography macromolecular models nuclear magnetic resonance structural biology
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