NESbase

Protein export from the nucleus is often mediated by a Leucine-rich nuclear export signal (NES) consisting of 4-5 hydrophobic residues within a region of approximately 10 amino acids. Many Leucine-rich NESs have been identified and reported in literature, but until now this information has not been compiled. NESbase is a database of experimentally validated Leucine-rich Nuclear Export Signals (NES) curated from literature. These signals are not annotated in databases such as SWISS-PROT, PIR or PROSITE. Each entry contains information of whether the NES was shown to be necessary and/or sufficient for export, and whether the export was shown to be mediated by the export receptor CRM1. Version 1.0 of NESbase contains 75 entries with 80 experimentally determined NESs. The database is available online at http://www.cbs.dtu.dk/databases/NESbase/

Webpage:
http://www.cbs.dtu.dk/databases/NESbase/

Tags:

protein sequence protein localization and targeting

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