MR-Base
Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes | This repository contains the case studies associated with the manuscript "Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes" | 2-sample Mendelian Randomisation | MR-base is a database and analytical platform for Mendelian randomization being developed by the MRC Integrative Epidemiology Unit at the University of Bristol
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Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes | This repository contains the case studies associated with the manuscript "Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes" | 2-sample Mendelian Randomisation | MR-base is a database and analytical platform for Mendelian randomization being developed by the MRC Integrative Epidemiology Unit at the University of Bristol
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:24:06.589756
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http://www.mrbase.org/Webpage
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Publications
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The MR-Base platform supports systematic causal inference across the human phenome
PMID: 29846171
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:06.589756
Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes
PMID: 31448343
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:06.589756
Publications
More detailed information about this field from each metasource.
The MR-Base platform supports systematic causal inference across the human phenome
PMID: 29846171
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:06.589756
Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes
PMID: 31448343
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:06.589756
-
The MR-Base platform supports systematic causal inference across the human phenome
PubMed citations: 788.
788 articles citing: The MR-Base platform supports systematic causal inference across the human phenome
Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease. PMID:35763030
Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes. PMID:35733147
Absence of causal association between Vitamin D and bone mineral density across the lifespan: a Mendelian randomization study. PMID:35729194
Alcohol consumption, blood DNA methylation and breast cancer: a Mendelian randomisation study. PMID:35708873
Identification of blood metabolites linked to the risk of cholelithiasis: a comprehensive Mendelian randomization study. PMID:35704268
Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations. PMID:35698167
Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants. PMID:35692035
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. PMID:35654975
Parental inflammatory bowel disease and autism in children. PMID:35654906
Exploring and mitigating potential bias when genetic instrumental variables are associated with multiple non-exposure traits in Mendelian randomization. PMID:35622304
Plasma Proteins as Occupational Hazard Risk Monitors for Populations Working in Harsh Environments: A Mendelian Randomization Study. PMID:35602164
Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremities. PMID:35594287
Higher Genetically Predicted Triglycerides, LDL, and HDL Increase the Vitamin D Deficiency: A Mendelian Randomization Study. PMID:35592626
Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank. PMID:35589863
Evidence of a Causal Link Between the Well-Being Spectrum and the Risk of Myocardial Infarction: A Mendelian Randomization Study. PMID:35571065
Cancers and COVID-19 Risk: A Mendelian Randomization Study. PMID:35565215
Is Hearing Impairment Causally Associated With Falls? Evidence From a Two-Sample Mendelian Randomization Study. PMID:35547384
Cardiovascular disease protein biomarkers are associated with kidney function: The Framingham Heart Study. PMID:35544531
Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics. PMID:35530264
Causal Association of Type 2 Diabetes Mellitus and Glycemic Traits With Cardiovascular Diseases and Lipid Traits: A Mendelian Randomization Study. PMID:35528012
A practical problem with Egger regression in Mendelian randomization. PMID:35507585
Placental multi-omics integration identifies candidate functional genes for birthweight. PMID:35501330
Using Mendelian randomisation to identify opportunities for type 2 diabetes prevention by repurposing medications used for lipid management. PMID:35500537
A Bidirectional Mendelian Randomization Study of Selenium Levels and Ischemic Stroke. PMID:35495125
The Causal Relationship Between Blood Lipids and Systemic Lupus Erythematosus Risk: A Bidirectional Two-Sample Mendelian Randomization Study. PMID:35495122
Analysis of Tryptophan and Its Main Metabolite Kynurenine and the Risk of Multiple Cancers Based on the Bidirectional Mendelian Randomization Analysis. PMID:35494045
Lifestyle and metabolic factors for nonalcoholic fatty liver disease: Mendelian randomization study. PMID:35488966
Genome- and epigenome-wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk. PMID:35475137
Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways. PMID:35472084
Mendelian Randomization Study of Heart Failure and Stroke Subtypes. PMID:35463787
Estimation of Causal Effect of Age at Menarche on Pubertal Height Growth Using Mendelian Randomization. PMID:35456516
Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways. PMID:35452290
Identifying causal genes for stroke via integrating the proteome and transcriptome from brain and blood. PMID:35449099
Does COVID-19 increase the risk of neuropsychiatric sequelae? Evidence from a mendelian randomization approach. PMID:35433322
Total Brain Volumetric Measures and Schizophrenia Risk: A Two-Sample Mendelian Randomization Study. PMID:35432453
Causal Associations of Circulating Lipids with Osteoarthritis: A Bidirectional Mendelian Randomization Study. PMID:35405941
Plasma Circulating Vitamin C Levels and Risk of Endometrial Cancer: A Bi-Directional Mendelian Randomization Analysis. PMID:35402429
Body Complexion and Circulating Lipids in the Risk of TDP-43 Related Disorders. PMID:35401153
Integrating brain imaging endophenotypes with GWAS for Alzheimer's disease. PMID:35399757
The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design. PMID:35399077
Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization. PMID:35396499
Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels. PMID:35396452
Effects of Vitamin D and Body Mass Index on Disease Risk and Relapse Hazard in Multiple Sclerosis: A Mendelian Randomization Study. PMID:35393342
Genetic Landscape of the ACE2 Coronavirus Receptor. PMID:35387486
Causal Association and Shared Genetics Between Asthma and COVID-19. PMID:35386719
Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study. PMID:35386698
The Effects of Plasma Homocysteine Level on the Risk of Three Major Psychiatric Disorders: A Mendelian Randomization Study. PMID:35386526
Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders. PMID:35385317
Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential. PMID:35385311
CSF sTREM2 in neurological diseases: a two-sample Mendelian randomization study. PMID:35382840
Multiple Sclerosis and the Risk of Cardiovascular Diseases: A Mendelian Randomization Study. PMID:35371017
Higher Coffee Consumption Is Associated With Reduced Cerebral Gray Matter Volume: A Mendelian Randomization Study. PMID:35369049
Genetic Predispositions Between COVID-19 and Three Cardio-Cerebrovascular Diseases. PMID:35368685
Environmental risk factors in multiple sclerosis: bridging Mendelian randomization and observational studies. PMID:35366084
Causal relationship between genetically predicted depression and cancer risk: a two-sample bi-directional mendelian randomization. PMID:35361153
Management of BMI Is a Potential New Approach for the Prevention of Idiopathic Pulmonary Fibrosis. PMID:35360873
The causal relationship between circulating cytokines and critically ill COVID-19: A bidirectional Mendelian randomization analysis. PMID:35356648
DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses. PMID:35354486
Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study. PMID:35346416
Estimating the Direct Effect between Dietary Macronutrients and Cardiometabolic Disease, Accounting for Mediation by Adiposity and Physical Activity. PMID:35334875
Genetic regulation of post-translational modification of two distinct proteins. PMID:35332118
The relationships between women's reproductive factors: a Mendelian randomisation analysis. PMID:35321746
Association Between Serum Total Bilirubin and COPD: Results from a Cross-Sectional Study and a Bidirectional Mendelian Randomization Analysis. PMID:35299727
Mendelian Randomization Analysis Suggests No Associations of Herpes Simplex Virus Infections With Multiple Sclerosis. PMID:35299622
A Mild Causal Relationship Between Tea Consumption and Obesity in General Population: A Two-Sample Mendelian Randomization Study. PMID:35281810
Genetically Predicted Circulating Copper and Risk of Chronic Kidney Disease: A Mendelian Randomization Study. PMID:35276868
Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer. PMID:35274198
Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women. PMID:35274129
Causal association evaluation of diabetes with Alzheimer's disease and genetic analysis of antidiabetic drugs against Alzheimer's disease. PMID:35272707
Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study. PMID:35268067
Dietary-Derived Essential Nutrients and Amyotrophic Lateral Sclerosis: A Two-Sample Mendelian Randomization Study. PMID:35267896
Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus. PMID:35264566
Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity. PMID:35254260
Educational attainment could be a protective factor against obstructive sleep apnea: a study based on Mendelian randomization. PMID:35242384
Association Between Neuroticism and Risk of Lung Cancer: Results From Observational and Mendelian Randomization Analyses. PMID:35237526
Genetic validation of neurokinin 3 receptor antagonists for ischemic heart disease prevention in men - A one-sample Mendelian randomization study. PMID:35231698
Genetically Predicted Circulating Omega-3 Fatty Acids Levels Are Causally Associated With Increased Risk for Systemic Lupus Erythematosus. PMID:35223943
Association of smoking, lung function and COPD in COVID-19 risk: a two-step Mendelian randomization study. PMID:35220625
Physical Activity and Systemic Lupus Erythematosus Among European Populations: A Two-Sample Mendelian Randomization Study. PMID:35211151
Cardiac Troponin I and Risk of Stroke: A Mendelian Randomization Study. PMID:35210829
Mendelian Randomization Study Implies Causal Linkage Between Telomere Length and Juvenile Idiopathic Arthritis in a European Population. PMID:35210806
Integrative Identification of Genetic Loci Jointly Influencing Diabetes-Related Traits and Sleep Traits of Insomnia, Sleep Duration, and Chronotypes. PMID:35203577
Circulating α-Klotho Levels in Relation to Cardiovascular Diseases: A Mendelian Randomization Study. PMID:35197934
The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections. PMID:35194621
Associations of Visceral Adipose Tissue, Circulating Protein Biomarkers, and Risk of Cardiovascular Diseases: A Mendelian Randomization Analysis. PMID:35186940
Mendelian Randomization: A Review of Methods for the Prevention, Assessment, and Discussion of Pleiotropy in Studies Using the Fat Mass and Obesity-Associated Gene as an Instrument for Adiposity. PMID:35186031
Gut Microbiota and Psychiatric Disorders: A Two-Sample Mendelian Randomization Study. PMID:35185808
Genetically Predicted Causality of 28 Gut Microbiome Families and Type 2 Diabetes Mellitus Risk. PMID:35185792
Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology. PMID:35177612
Assessing the role of blood pressure in amyotrophic lateral sclerosis: a Mendelian randomization study. PMID:35172853
Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study. PMID:35172829
Circulating polyunsaturated fatty acids and COVID-19: a prospective cohort study and Mendelian randomization analysis. PMID:35169810
Body mass index and adipose distribution have opposing genetic impacts on human blood traits. PMID:35166671
Association of Atopic Dermatitis with Depression and Suicide: A Two-Sample Mendelian Randomization Study. PMID:35155673
No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis. PMID:35154127
No Causal Association Between Coffee Consumption and Risk of Migraine: A Mendelian Randomization Study. PMID:35145549
Association between depression and sleep apnoea: a Mendelian randomisation study. PMID:35141322
Maternal Hypertension Increases Risk of Preeclampsia and Low Fetal Birthweight: Genetic Evidence From a Mendelian Randomization Study. PMID:35138876
Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies. PMID:35134646
Association between Circulating Antioxidants and Longevity: Insight from Mendelian Randomization Study. PMID:35132376
Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes. PMID:35129650
Migraine, Stroke, and Cervical Arterial Dissection: Shared Genetics for a Triad of Brain Disorders With Vascular Involvement. PMID:35128049
Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study. PMID:35119566
Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project. PMID:35115690
Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort. PMID:35115689
Inflammatory Cytokines and Risk of Ischemic Stroke: A Mendelian Randomization Study. PMID:35111052
Obesity and risk of female reproductive conditions: A Mendelian randomisation study. PMID:35104295
Mendelian randomization study of obesity and type 2 diabetes in hospitalized COVID-19 patients. PMID:35101533
Genetic Determinants of Serum Calcification Propensity and Cardiovascular Outcomes in the General Population. PMID:35097025
Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization. PMID:35094705
Causal Association Between Heart Failure and Alzheimer's Disease: A Two-Sample Bidirectional Mendelian Randomization Study. PMID:35087565
Rho GTPase gene expression and breast cancer risk: a Mendelian randomization analysis. PMID:35087170
Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity. PMID:35085229
Evidence for shared genetic risk factors between lymphangioleiomyomatosis and pulmonary function. PMID:35083324
Causal Association Between Periodontitis and Type 2 Diabetes: A Bidirectional Two-Sample Mendelian Randomization Analysis. PMID:35082834
Coding and regulatory variants are associated with serum protein levels and disease. PMID:35079000
Mendelian randomization analyses implicate biogenesis of translation machinery in human aging. PMID:35078808
Examining Health Outcomes in Juvenile Idiopathic Arthritis: A Genetic Epidemiology Study. PMID:35077020
Mendelian randomization study on the causal effects of tumor necrosis factor inhibition on coronary artery disease and ischemic stroke among the general population. PMID:35074627
Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization. PMID:35070816
A multiethnic bidirectional Mendelian randomization study negates causal effects of C-reactive protein concentrations on lung cancer. PMID:35070748
Multigenomics Reveals the Causal Effect of Herpes Simplex Virus in Alzheimer's Disease: A Two-Sample Mendelian Randomization Study. PMID:35069681
Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? A Mendelian randomization study. PMID:35061662
The Effect of Circulating Zinc, Selenium, Copper and Vitamin K1 on COVID-19 Outcomes: A Mendelian Randomization Study. PMID:35057415
Morning Cortisol and Circulating Inflammatory Cytokine Levels: A Mendelian Randomisation Study. PMID:35052454
Sleep Disordered Breathing, Obesity and Atrial Fibrillation: A Mendelian Randomisation Study. PMID:35052444
Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility? PMID:35050305
Sex hormones, adiposity, and metabolic traits in men and women: a Mendelian randomisation study. PMID:35049520
Mendelian randomisation analyses of UK Biobank and published data suggest that increased adiposity lowers risk of breast and prostate cancer. PMID:35042869
Associations between body composition, fat distribution and metabolic consequences of excess adiposity with severe COVID-19 outcomes: observational study and Mendelian randomisation analysis. PMID:35031696
The genetic and epigenetic profile of serum S100β in the Lothian Birth Cohort 1936 and its relationship to Alzheimer's disease. PMID:35028426
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia. PMID:35023831
A multi-omics study of circulating phospholipid markers of blood pressure. PMID:35022422
Metabolic and lifestyle factors in relation to senile cataract: a Mendelian randomization study. PMID:35013517
Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia. PMID:35013163
Genetically Predicted Higher Educational Attainment Decreases the Risk of COVID-19 Susceptibility and Severity: A Mendelian Randomization Study. PMID:35004565
Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease. PMID:34999880
Is genetic liability to ADHD and ASD causally linked to educational attainment? PMID:34999873
Network Mendelian randomization study: exploring the causal pathway from insomnia to type 2 diabetes. PMID:34996781
Diet-Derived Antioxidants and Risk of Kidney Stone Disease: Results From the NHANES 2007-2018 and Mendelian Randomization Study. PMID:34993217
Investigating the Causal Relationship Between Physical Activity and Chronic Back Pain: A Bidirectional Two-Sample Mendelian Randomization Study. PMID:34987546
Novel insights into the consequences of obesity: a phenotype-wide Mendelian randomization study. PMID:34974530
Genomic insights in ascending aortic size and distensibility. PMID:34968759
Causal Associations of Obesity With the Intervertebral Degeneration, Low Back Pain, and Sciatica: A Two-Sample Mendelian Randomization Study. PMID:34956075
Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study. PMID:34952598
Association of Thyroid Function with Blood Pressure and Cardiovascular Disease: A Mendelian Randomization. PMID:34945778
A Comprehensive Evaluation of Cross-Omics Blood-Based Biomarkers for Neuropsychiatric Disorders. PMID:34945719
Interplay between Genome, Metabolome and Microbiome in Colorectal Cancer. PMID:34944836
Identifying Putative Causal Links between MicroRNAs and Severe COVID-19 Using Mendelian Randomization. PMID:34944012
The absence of association between anorexia nervosa and smoking: converging evidence across two studies. PMID:34939143
Two-Sample Multivariable Mendelian Randomization Analysis Using R. PMID:34936225
Finding genetically-supported drug targets for Parkinson's disease using Mendelian randomization of the druggable genome. PMID:34930919
Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases. PMID:34926542
Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis. PMID:34925448
Deciphering the Irregular Risk of Stroke Increased by Obesity Classes: A Stratified Mendelian Randomization Study. PMID:34925231
Reciprocal interaction between depression and pain: results from a comprehensive bidirectional Mendelian randomization study and functional annotation analysis. PMID:34924553
Stroke and Myocardial Infarction: A Bidirectional Mendelian Randomization Study. PMID:34916835
Heart Failure and Ischemic Stroke: A Bidirectional and Multivariable Mendelian Randomization Study. PMID:34912375
Interleukin-18 and COVID-19. PMID:34911594
Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics. PMID:34907193
Leukocyte telomere length and amyotrophic lateral sclerosis: a Mendelian randomization study. PMID:34906191
Migraine and Ischemic Stroke: A Mendelian Randomization Study. PMID:34904213
Causal Inference of Carnitine on Blood Pressure and potential mediation by uric acid: A mendelian randomization analysis. PMID:34901954
Carnitine and COVID-19 Susceptibility and Severity: A Mendelian Randomization Study. PMID:34901126
Univariable and Multivariable Two-Sample Mendelian Randomization Investigating the Effects of Leisure Sedentary Behaviors on the Risk of Lung Cancer. PMID:34899835
Credible Mendelian Randomization Studies in the Presence of Selection Bias Using Control Exposures. PMID:34899831
Gluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis. PMID:34899821
Causal effect of atrial fibrillation/flutter on chronic kidney disease: A bidirectional two-sample Mendelian randomization study. PMID:34898631
Mendelian randomization analysis of the causal impact of body mass index and waist-hip ratio on rates of hospital admission. PMID:34894623
Meta-analyses identify DNA methylation associated with kidney function and damage. PMID:34887417
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus. PMID:34887389
The Association of Waist Circumference and the Risk of Deep Vein Thrombosis. PMID:34880666
Mitochondrial DNA Copy Number as a Marker and Mediator of Stroke Prognosis: Observational and Mendelian Randomization Analyses. PMID:34880091
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. PMID:34873335
Causal Effects of Genetically Predicted Iron Status on Sepsis: A Two-Sample Bidirectional Mendelian Randomization Study. PMID:34869523
Matrix Metalloproteinases in Relation to Bone Mineral Density: A Two-Sample Mendelian Randomization Study. PMID:34868227
Shared Genetic Liability and Causal Associations Between Major Depressive Disorder and Cardiovascular Diseases. PMID:34859065
Serum Albumin and Circulating Metabolites and Risk of Venous Thromboembolism: A Two-Sample Mendelian Randomization Study. PMID:34859025
Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study. PMID:34858335
Mapping the serum proteome to neurological diseases using whole genome sequencing. PMID:34857772
Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study. PMID:34840730
Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study. PMID:34836419
Recent Trends in Cancer Genomics and Bioinformatics Tools Development. PMID:34830028
Multi-Omics Interpretation of Anti-Aging Mechanisms for ω-3 Fatty Acids. PMID:34828297
Causal effects of atrial fibrillation on brain white and gray matter volume: a Mendelian randomization study. PMID:34814924
Assessing causal relationships between COVID-19 and non-alcoholic fatty liver disease. PMID:34813919
Mendelian Randomization Identifies the Potential Causal Impact of Dietary Patterns on Circulating Blood Metabolites. PMID:34790224
Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol. PMID:34789503
A selection pressure landscape for 870 human polygenic traits. PMID:34782732
Leisure Sedentary Behavior and Risk of Lung Cancer: A Two-Sample Mendelian Randomization Study and Mediation Analysis. PMID:34777480
Examining the Causal Inference of Leptin and Soluble Plasma Leptin Receptor Levels on Schizophrenia: A Mendelian Randomization Study. PMID:34777056
Estimating causal effects of atherogenic lipid-related traits on COVID-19 susceptibility and severity using a two-sample Mendelian randomization approach. PMID:34774031
Health Effects of Calcium: Evidence From Mendelian Randomization Studies. PMID:34761146
Obesity and Cardiovascular Disease: The Emerging Role of Inflammation. PMID:34760952
Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction. PMID:34750467
Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study. PMID:34745219
Growth Factors and Their Roles in Multiple Sclerosis Risk. PMID:34745143
Integrative multiomics analysis highlights immune-cell regulatory mechanisms and shared genetic architecture for 14 immune-associated diseases and cancer outcomes. PMID:34741802
Vitamin D and the risk of treatment-resistant and atypical depression: A Mendelian randomization study. PMID:34737282
Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation. PMID:34732054
Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a mendelian randomisation analysis using outcomes in first-degree relatives. PMID:34729547
Postdiagnosis BMI Change Is Associated with Non-Small Cell Lung Cancer Survival. PMID:34728470
Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling. PMID:34727949
White Matter Integrity and Nicotine Dependence: Evaluating Vertical and Horizontal Pleiotropy. PMID:34720862
Smoking is significantly associated with increased risk of COVID-19 and other respiratory infections. PMID:34711921
A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases. PMID:34704651
Causal Relationships Between Social Isolation and Osteoarthritis: A Mendelian Randomization Study in European Population. PMID:34703283
Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration. PMID:34702754
Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. PMID:34675202
Genome-wide association study of colorectal polyps identified highly overlapping polygenic architecture with colorectal cancer. PMID:34671089
Causal relationship between educational attainment and the risk of rheumatoid arthritis: a Mendelian randomization study. PMID:34670623
Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease. PMID:34669934
Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke. PMID:34668383
Cardiometabolic, Lifestyle, and Nutritional Factors in Relation to Varicose Veins: A Mendelian Randomization Study. PMID:34666504
Smoking, DNA Methylation, and Breast Cancer: A Mendelian Randomization Study. PMID:34650928
Serum calcium and 25-hydroxyvitamin D in relation to longevity, cardiovascular disease and cancer: a Mendelian randomization study. PMID:34650087
An informatics consult approach for generating clinical evidence for treatment decisions. PMID:34641870
Phenotypic and Genotypic Associations Between Migraine and Lipoprotein Subfractions. PMID:34635557
Joint Analysis of Genome-Wide Association Data Reveals No Genetic Correlations Between Low Back Pain and Neurodegenerative Diseases. PMID:34630533
Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and composition. PMID:34611531
A Chinese host genetic study discovered IFNs and causality of laboratory traits on COVID-19 severity. PMID:34608450
Serum Estradiol and 20 Site-Specific Cancers in Women: Mendelian Randomization Study. PMID:34601599
Using a Two-Sample Mendelian Randomization Method in Assessing the Causal Relationships Between Human Blood Metabolites and Heart Failure. PMID:34595216
Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study. PMID:34594363
Associations Between Genetically Predicted Plasma N-Glycans and Prostate Cancer Risk: Analysis of Over 140,000 European Descendants. PMID:34588798
Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension. PMID:34588193
Epigenetic Age and the Risk of Incident Atrial Fibrillation. PMID:34587750
Investigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study. PMID:34583967
Smoking and COVID-19 outcomes: an observational and Mendelian randomisation study using the UK Biobank cohort. PMID:34580193
Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use. PMID:34569141
Effect of Basal Metabolic Rate on Cancer: A Mendelian Randomization Study. PMID:34567085
Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases. PMID:34561436
Herpesvirus infections and Alzheimer's disease: a Mendelian randomization study. PMID:34560893
The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium. PMID:34543281
High Level of Uromodulin Increases the Risk of Hypertension: A Mendelian Randomization Study. PMID:34540925
Genetic Associations Between IL-6 and the Development of Autoimmune Arthritis Are Gender-Specific. PMID:34539640
Systematic Influence of Circulating Bilirubin Levels on Osteoporosis. PMID:34539572
Genetically determined low income modifies Alzheimer's disease risk. PMID:34532359
Mendelian randomization reveals potential causal candidates for COVID-19 in 123 blood metabolites. PMID:34530029
Cortical structure and the risk for Alzheimer's disease: a bidirectional Mendelian randomization study. PMID:34526483
Blood copper and risk of cardiometabolic diseases: a Mendelian randomization study. PMID:34523676
An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank. PMID:34521884
Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape. PMID:34518635
Educational level as a cause of type 2 diabetes mellitus: Caution from triangulation of observational and genetic evidence. PMID:34514530
Thyroid Function and Risk of Anemia: A Multivariable-Adjusted and Mendelian Randomization Analysis in the UK Biobank. PMID:34514498
SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues. PMID:34502134
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. PMID:34493871
Using multiple Mendelian randomization approaches and genetic correlations to understand obesity, urate, and gout. PMID:34493793
Growth Differentiation Factor 15 Is Associated With Alzheimer's Disease Risk. PMID:34484296
Graves' Disease and Rheumatoid Arthritis: A Bidirectional Mendelian Randomization Study. PMID:34484118
Relationship between genetically determined telomere length and glioma risk. PMID:34477880
Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological repeat expansions. PMID:34475377
Human gut microbiome impacts skeletal muscle mass via gut microbial synthesis of the short-chain fatty acid butyrate among healthy menopausal women. PMID:34472211
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study. PMID:34465810
Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body Size. PMID:34465205
Grey and white matter microstructure is associated with polygenic risk for schizophrenia. PMID:34462574
Assessing Genetic Overlap and Causality Between Blood Plasma Proteins and Alzheimer's Disease. PMID:34459398
Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation. PMID:34456968
A genome-wide cross-trait analysis highlights the shared genetic structure between COVID-19 and Alzheimer's disease. PMID:34454957
Shared Genetic Background between Parkinson's Disease and Schizophrenia: A Two-Sample Mendelian Randomization Study. PMID:34439661
Genetic Determinants of Increased Body Mass Index Partially Mediate the Effect of Elevated Birth Weight on the Increased Risk of Atrial Fibrillation. PMID:34422928
Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study. PMID:34421826
Identifying causal models between genetically regulated methylation patterns and gene expression in healthy colon tissue. PMID:34419169
Association Between Insomnia and Migraine Risk: A Case-Control and Bidirectional Mendelian Randomization Study. PMID:34413668
Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease. PMID:34413458
SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release. PMID:34401873
Ten simple rules for conducting a mendelian randomization study. PMID:34383747
Exploiting collider bias to apply two-sample summary data Mendelian randomization methods to one-sample individual level data. PMID:34370750
Genetically Predicted Fibroblast Growth Factor 23 and Major Cardiovascular Diseases, Their Risk Factors, Kidney Function, and Longevity: A Two-Sample Mendelian Randomization Study. PMID:34367258
A Causal Web between Chronotype and Metabolic Health Traits. PMID:34356044
Causal effects of education on chronic kidney disease: a Mendelian randomization study. PMID:34345417
Genome-wide association study identifies 18 novel loci associated with left atrial volume and function. PMID:34338756
Smoking quantitatively increases risk for COVID-19. PMID:34326191
Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study. PMID:34325683
Causal linkage between adult height and kidney function: An integrated population-scale observational analysis and Mendelian randomization study. PMID:34324541
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study. PMID:34324486
Relationship between lung function and lung cancer risk: a pooled analysis of cohorts plus Mendelian randomization study. PMID:34318357
Telomere length and metabolic syndrome traits: A Mendelian randomisation study. PMID:34312982
Twin studies to GWAS: there and back again. PMID:34312064
Genetically predicted serum vitamin D and COVID-19: a Mendelian randomisation study. PMID:34308129
No evidence that vitamin D is able to prevent or affect the severity of COVID-19 in individuals with European ancestry: a Mendelian randomisation study of open data. PMID:34308111
Causal Associations of Urate With Cardiovascular Risk Factors: Two-Sample Mendelian Randomization. PMID:34306027
Advancing the use of genome-wide association studies for drug repurposing. PMID:34302145
Hearing difficulty is linked to Alzheimer's disease by common genetic vulnerability, not shared genetic architecture. PMID:34294723
Genetic overlap and causal associations between smoking behaviours and mental health. PMID:34290290
Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry. PMID:34282949
Investigating causal relationships between exposome and human longevity: a Mendelian randomization analysis. PMID:34281550
Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus. PMID:34268601
Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia. PMID:34261659
Depression and Osteoporosis: A Mendelian Randomization Study. PMID:34259888
Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density. PMID:34255042
Effect of Body Weight on Age at Onset in Huntington Disease: A Mendelian Randomization Study. PMID:34250226
Two genetic analyses to elucidate causality between body mass index and personality. PMID:34247202
Using genetic variants to evaluate the causal effect of serum vitamin D concentration on COVID-19 susceptibility, severity and hospitalization traits: a Mendelian randomization study. PMID:34246301
Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. PMID:34244212
Alcohol Consumption and Risk of Common Autoimmune Inflammatory Diseases-Evidence From a Large-Scale Genetic Analysis Totaling 1 Million Individuals. PMID:34239545
Genetically Predicted Cigarette Smoking in Relation to Risk of Polycystic Ovary Syndrome. PMID:34239329
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders. PMID:34239129
Mapping the human genetic architecture of COVID-19. PMID:34237774
Examining the possible causal relationship between lung function, COPD and Alzheimer's disease: a Mendelian randomisation study. PMID:34233891
Genetic evidence for a causative effect of airflow obstruction on left ventricular filling: a Mendelian randomisation study. PMID:34233669
Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease. PMID:34229738
Search for AL amyloidosis risk factors using Mendelian randomization. PMID:34228109
Genetics of substance use disorders in the era of big data. PMID:34211176
Polycystic Ovary Syndrome Susceptibility Loci Inform Disease Etiological Heterogeneity. PMID:34207127
Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study. PMID:34203356
Genetic Contribution of Endometriosis to the Risk of Developing Hormone-Related Cancers. PMID:34199930
Genetically predicted body composition in relation to cardiometabolic traits: a Mendelian randomization study. PMID:34195880
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. PMID:34187551
A phenome-wide association study of genetically mimicked statins. PMID:34187478
Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure. PMID:34184541
Association of Autism Spectrum Disorder, Neuroticism, and Subjective Well-Being With Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study. PMID:34179139
Multi-Omics Approaches in Immunological Research. PMID:34177908
Genetically increased circulating FUT3 level leads to reduced risk of idiopathic pulmonary fibrosis: a Mendelian randomisation study. PMID:34172473
Association of Interleukin-6 Signaling and C-Reactive Protein With Intracranial Aneurysm: A Mendelian Randomization and Genetic Correlation Study. PMID:34168680
Novel loci and potential mechanisms of major depressive disorder, bipolar disorder, and schizophrenia. PMID:34159505
Associations of Alcohol Consumption with Cardiovascular Disease-Related Proteomic Biomarkers: The Framingham Heart Study. PMID:34159370
Effects of increased body mass index on employment status: a Mendelian randomisation study. PMID:34158612
The causal effects of serum lipids and apolipoproteins on kidney function: multivariable and bidirectional Mendelian-randomization analyses. PMID:34151951
Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study. PMID:34150709
A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts. PMID:34140684
Mendelian Randomization Analysis as a Tool to Gain Insights into Causes of Diseases: A Primer. PMID:34135084
Plasma Proteomics of Renal Function: A Trans-ethnic Meta-analysis and Mendelian Randomization Study. PMID:34135082
Plasma Proteomics of COVID-19 Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics. PMID:34127963
Liver and Kidney Function Biomarkers, Blood Cell Traits and Risk of Severe COVID-19: A Mendelian Randomization Study. PMID:34122505
Appraising the Causal Association of Plasma Homocysteine Levels With Atrial Fibrillation Risk: A Two-Sample Mendelian Randomization Study. PMID:34122499
Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease. PMID:34112112
Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume. PMID:34104963
The Causal Relationship Between Body Mass Index and the Risk of Osteoarthritis. PMID:34103976
Is genetic liability to ADHD and ASD causally linked to educational attainment? PMID:34096993
Habitual Sleep Duration, Daytime Napping, and Dietary Intake: A Mendelian Randomization Study. PMID:34095735
Mendelian randomization studies of brain MRI yield insights into the pathogenesis of neuropsychiatric disorders. PMID:34078268
Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study. PMID:34074296
Prepubertal Dietary and Plasma Phospholipid Fatty Acids Related to Puberty Timing: Longitudinal Cohort and Mendelian Randomization Analyses. PMID:34070864
Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation. PMID:34043151
Genetically Proxied Diurnal Preference, Sleep Timing, and Risk of Major Depressive Disorder. PMID:34037671
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome. PMID:34032881
A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization. PMID:34027348
Metabolic syndrome and the plasma proteome: from association to causation. PMID:34016094
Rheumatoid arthritis and osteoporosis: a bi-directional Mendelian randomization study. PMID:34015765
Age at first birth and lung cancer: a two-sample Mendelian randomization study. PMID:34012788
Caution against examining the role of reverse causality in Mendelian Randomization. PMID:34008876
Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations. PMID:34002374
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. PMID:34002096
Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysis. PMID:34002035
MRPC: An R Package for Inference of Causal Graphs. PMID:33995486
Assessing the Causal Relationships Between Insulin Resistance and Hyperuricemia and Gout Using Bidirectional Mendelian Randomization. PMID:33982892
Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images. PMID:33979322
Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles. PMID:33972266
Genome-wide association study of cardiac troponin I in the general population. PMID:33961016
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney. PMID:33958779
Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example. PMID:33946982
Genetic Evidence Supporting Fibroblast Growth Factor 21 Signalling as a Pharmacological Target for Cardiometabolic Outcomes and Alzheimer's Disease. PMID:33946944
Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization Study. PMID:33924952
Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between participants of European descent and other ancestry groups from the UK Biobank. PMID:33890984
Genetic analyses identify widespread sex-differential participation bias. PMID:33888908
Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study. PMID:33888102
Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank. PMID:33887147
DNA methylation biomarkers of myocardial infarction and cardiovascular disease. PMID:33883000
Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease. PMID:33879569
Atrial fibrillation and left atrial size and function: a Mendelian randomization study. PMID:33875748
MRLocus: Identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity. PMID:33872308
A Mendelian Randomization Study of Plasma Homocysteine Levels and Cerebrovascular and Neurodegenerative Diseases. PMID:33868384
Assessment of Bidirectional Relationships Between Polycystic Ovary Syndrome and Periodontitis: Insights From a Mendelian Randomization Analysis. PMID:33868379
Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease. PMID:33853351
Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19. PMID:33851187
Genetically predicted bipolar disorder is causally associated with an increased risk of breast cancer: a two-sample Mendelian randomization analysis. PMID:33842622
Genetically predicted circulating B vitamins in relation to digestive system cancers. PMID:33837300
Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study. PMID:33834859
Are psychiatric disorders risk factors for COVID-19 susceptibility and severity? a two-sample, bidirectional, univariable, and multivariable Mendelian Randomization study. PMID:33833219
Effects of selenium on coronary artery disease, type 2 diabetes and their risk factors: a Mendelian randomization study. PMID:33828238
Effect of selection bias on two sample summary data based Mendelian randomization. PMID:33828182
Mendelian randomization as an approach to assess causal effects of inflammatory bowel disease on atrial fibrillation. PMID:33824227
White Blood Cells and Severe COVID-19: A Mendelian Randomization Study. PMID:33809027
Common Genetic Variation in MC4R Does Not Affect Atherosclerotic Plaque Phenotypes and Cardiovascular Disease Outcomes. PMID:33804309
Causal Effects of Homocysteine, Folate, and Cobalamin on Kidney Function: A Mendelian Randomization Study. PMID:33799553
Association Between Hemostatic Profile and Migraine: A Mendelian Randomization Analysis. PMID:33795393
Exploring the Causality Between Hypothyroidism and Non-alcoholic Fatty Liver: A Mendelian Randomization Study. PMID:33791302
Causal Effects of Positive Affect, Life Satisfaction, Depressive Symptoms, and Neuroticism on Kidney Function: A Mendelian Randomization Study. PMID:33785582
Sclerostin Downregulation Globally by Naturally Occurring Genetic Variants, or Locally in Atherosclerotic Plaques, Does Not Associate With Cardiovascular Events in Humans. PMID:33784435
Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis. PMID:33783488
Gallstone disease, diabetes, calcium, triglycerides, smoking and alcohol consumption and pancreatitis risk: Mendelian randomization study. PMID:33782414
The Diabetes Syndrome - A Collection of Conditions with Common, Interrelated Pathophysiologic Mechanisms. PMID:33776471
Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study. PMID:33774696
Serum Uric Acid Levels and Risk of Eight Site-Specific Cancers: A Mendelian Randomization Study. PMID:33767728
SVEP1 is a human coronary artery disease locus that promotes atherosclerosis. PMID:33762433
Causal effect of education on type 2 diabetes: A network Mendelian randomization study. PMID:33758646
Evaluation of glycemic traits in susceptibility to COVID-19 risk: a Mendelian randomization study. PMID:33757497
Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases. PMID:33752734
Advancing drug discovery using the power of the human genome. PMID:33748968
Identification of Novel Pleiotropic SNPs Associated with Osteoporosis and Rheumatoid Arthritis. PMID:33740106
Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses. PMID:33731105
Prospective Study on Plasma MicroRNA-4286 and Incident Acute Coronary Syndrome. PMID:33719498
Systematic identification of risk factors and drug repurposing options for Alzheimer's disease. PMID:33718584
Genetic liability to insomnia in relation to cardiovascular diseases: a Mendelian randomisation study. PMID:33712906
Selection into shift work is influenced by educational attainment and body mass index: a Mendelian randomization study in the UK Biobank. PMID:33712841
Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development. PMID:33707768
Type 2 Diabetes as a Determinant of Parkinson's Disease Risk and Progression. PMID:33682937
Assessment of Causal Direction Between Gut Microbiota and Inflammatory Bowel Disease: A Mendelian Randomization Analysis. PMID:33679893
No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis. PMID:33679875
Heart rate, intelligence in adolescence, and Parkinson's disease later in life. PMID:33675447
Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection. PMID:33667465
Genetic susceptibility, elevated blood pressure, and risk of atrial fibrillation: a Mendelian randomization study. PMID:33663581
Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis. PMID:33661905
Opportunities and Challenges in Functional Genomics Research in Osteoporosis: Report From a Workshop Held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020. PMID:33658983
Rheumatoid arthritis decreases risk for Parkinson's disease: a Mendelian randomization study. PMID:33654087
Causal relationship between the timing of menarche and young adult body mass index with consideration to a trend of consistently decreasing age at menarche. PMID:33635908
Causal associations of waist circumference and waist-to-hip ratio with type II diabetes mellitus: new evidence from Mendelian randomization. PMID:33629185
Revealing the role of the human blood plasma proteome in obesity using genetic drivers. PMID:33627659
[Investigating the causal relationship between human blood metabolites and coronary artery disease using two-sample Mendelian randomization]. PMID:33624602
Genetically predicted education attainment in relation to somatic and mental health. PMID:33619316
Mendelian randomization highlights insomnia as a risk factor for pain diagnoses. PMID:33608734
Tumor Necrosis Factor Inhibition and Parkinson Disease: A Mendelian Randomization Study. PMID:33608417
A genetically-informed study disentangling the relationships between tobacco smoking, cannabis use, alcohol consumption, substance use disorders and respiratory infections, including COVID-19. PMID:33594380
The use of negative control outcomes in Mendelian randomization to detect potential population stratification. PMID:33570130
Genetic determinants of daytime napping and effects on cardiometabolic health. PMID:33568662
Elucidation of disease etiology by trans-layer omics analysis. PMID:33557957
Causal Effect of the Triglyceride-Glucose Index and the Joint Exposure of Higher Glucose and Triglyceride With Extensive Cardio-Cerebrovascular Metabolic Outcomes in the UK Biobank: A Mendelian Randomization Study. PMID:33553250
Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to severe SARS-CoV-2. PMID:33548839
Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts. PMID:33542229
Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits. PMID:33541420
Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study. PMID:33536004
Associations of biogeographic ancestry with hypertension traits. PMID:33534346
Mendelian randomisation with coarsened exposures. PMID:33527565
Lower Lymphocyte Count is Associated With Increased Risk of Parkinson's Disease. PMID:33527442
Type 2 Diabetes and Glycemic Traits Are Not Causal Factors of Osteoarthritis: A Two-Sample Mendelian Randomization Analysis. PMID:33519901
Assessment of causal effects of physical activity on neurodegenerative diseases: A Mendelian randomization study. PMID:33515719
Genetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study. PMID:33510439
Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. PMID:33510174
Body mass index and colorectal cancer risk: A Mendelian randomization study. PMID:33506574
Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility. PMID:33504897
Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity. PMID:33495597
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect. PMID:33495596
The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease. PMID:33491305
Causal effect between total cholesterol and HDL cholesterol as risk factors for chronic kidney disease: a mendelian randomization study. PMID:33472594
Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease. PMID:33469137
Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study. PMID:33464320
Large-scale association analyses identify host factors influencing human gut microbiome composition. PMID:33462485
Genetics of 35 blood and urine biomarkers in the UK Biobank. PMID:33462484
Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome. PMID:33462482
Thyrotrophin and thyroxine support immune homeostasis in humans. PMID:33454989
The variant call format provides efficient and robust storage of GWAS summary statistics. PMID:33441155
Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations. PMID:33437055
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization. PMID:33431812
Exploring the Relationship Between Psychiatric Traits and the Risk of Mouth Ulcers Using Bi-Directional Mendelian Randomization. PMID:33424931
Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study. PMID:33422704
Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome. PMID:33417599
Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: a Mendelian randomisation analysis. PMID:33414539
Identification of novel SNPs associated with coronary artery disease and birth weight using a pleiotropic cFDR method. PMID:33411684
Causal Evaluation of Laboratory Markers in Type 2 Diabetes on Cancer and Vascular Diseases Using Various Mendelian Randomization Tools. PMID:33408737
A Systematic Two-Sample Mendelian Randomization Analysis Identifies Shared Genetic Origin of Endometriosis and Associated Phenotypes. PMID:33401535
Common health conditions in childhood and adolescence, school absence, and educational attainment: Mendelian randomization study. PMID:33398003
ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study. PMID:33391794
Genetically Predicted Blood Pressure and Risk of Atrial Fibrillation. PMID:33390040
Investigating Causal Relations Between Sleep-Related Traits and Risk of Type 2 Diabetes Mellitus: A Mendelian Randomization Study. PMID:33384720
Genetically increased circulating 25(OH)D level reduces the risk of type 2 diabetes in subjects with deficiency of vitamin D: A large-scale Mendelian randomization study. PMID:33371106
A Mendelian randomization of γ' and total fibrinogen levels in relation to venous thromboembolism and ischemic stroke. PMID:33367543
Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials. PMID:33356394
Mendelian Randomization Study on Amino Acid Metabolism Suggests Tyrosine as Causal Trait for Type 2 Diabetes. PMID:33352682
The effect of angiotensin-converting enzyme levels on COVID-19 susceptibility and severity: a Mendelian randomization study. PMID:33349849
Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption: A Gene-Diet Interaction Study from the UK Biobank. PMID:33333105
Bidirectional Causal Associations Between Inflammatory Bowel Disease and Ankylosing Spondylitis: A Two-Sample Mendelian Randomization Analysis. PMID:33329731
Genetic architecture of host proteins involved in SARS-CoV-2 infection. PMID:33328453
Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study. PMID:33327948
Mendelian randomization study of telomere length and bone mineral density. PMID:33323545
A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer. PMID:33318029
Association of physical activity and sedentary behavior with type 2 diabetes and glycemic traits: a two-sample Mendelian randomization study. PMID:33293297
Risk Factors for Polyvascular Involvement in Patients With Peripheral Artery Disease: A Mendelian Randomization Study. PMID:33287626
Does Maternal Normal Range Thyroid Function Play a Role in Offspring Birth Weight? Evidence From a Mendelian Randomization Analysis. PMID:33281750
Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study. PMID:33275596
Education and stroke: evidence from epidemiology and Mendelian randomization study. PMID:33273579
Causal Inference for Genetic Obesity, Cardiometabolic Profile and COVID-19 Susceptibility: A Mendelian Randomization Study. PMID:33262790
Little evidence for an effect of smoking on multiple sclerosis risk: A Mendelian Randomization study. PMID:33253141
Circulating insulin-like growth factor-I, total and free testosterone concentrations and prostate cancer risk in 200 000 men in UK Biobank. PMID:33252839
A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer. PMID:33247085
Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities. PMID:33233416
15 years of genome-wide association studies and no signs of slowing down. PMID:33214558
Genetically proxied interleukin-6 receptor inhibition: opposing associations with COVID-19 and pneumonia. PMID:33214204
Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease. PMID:33213513
Plasma proteomic biomarker signature of age predicts health and life span. PMID:33210602
Association between systemic lupus erythematosus and lung cancer: results from a pool of cohort studies and Mendelian randomization analysis. PMID:33209364
Accelerated MRI-predicted brain ageing and its associations with cardiometabolic and brain disorders. PMID:33203906
A phenome-wide association study of ABO blood groups. PMID:33198801
Breast cancer risk factors and their effects on survival: a Mendelian randomisation study. PMID:33198768
Examining the association between family status and depression in the UK Biobank. PMID:33189065
The Role of Gallstones in Gallbladder Cancer in India: A Mendelian Randomization Study. PMID:33187967
Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders: A Multivariable Mendelian Randomization Analysis. PMID:33175090
Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women. PMID:33173903
Educational attainment reduces the risk of suicide attempt among individuals with and without psychiatric disorders independent of cognition: a bidirectional and multivariable Mendelian randomization study with more than 815,000 participants. PMID:33168806
Mendelian randomization study of inflammatory bowel disease and bone mineral density. PMID:33167994
EpiGraphDB: a database and data mining platform for health data science. PMID:33165574
The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship. PMID:33152005
Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. PMID:33150399
Inferring causal direction between two traits in the presence of horizontal pleiotropy with GWAS summary data. PMID:33137120
Habitual sleep disturbances and migraine: a Mendelian randomization study. PMID:33125193
Sleep Duration and Stroke: A Mendelian Randomization Study. PMID:33117250
Causal Effects of Sleep Traits on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study. PMID:33117014
The COVID-19 Pandemic from a Human Genetic Perspective. PMID:33084340
The Causal Effects of Blood Iron and Copper on Lipid Metabolism Diseases: Evidence from Phenome-Wide Mendelian Randomization Study. PMID:33080795
Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study. PMID:33079133
Automated feature extraction from population wearable device data identified novel loci associated with sleep and circadian rhythms. PMID:33075057
Effects of lifelong testosterone exposure on health and disease using Mendelian randomization. PMID:33063668
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. PMID:33057200
Association between genetically predicted telomere length and facial skin aging in the UK Biobank: a Mendelian randomization study. PMID:33033864
Genetics of height and risk of atrial fibrillation: A Mendelian randomization study. PMID:33031386
Understanding the nature of association between anxiety phenotypes and anorexia nervosa: a triangulation approach. PMID:33028263
Mendelian randomization provides evidence for a causal effect of higher serum IGF-1 concentration on risk of hip and knee osteoarthritis. PMID:33027520
Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study. PMID:33020596
Assessment and visualization of phenome-wide causal relationships using genetic data: an application to dental caries and periodontitis. PMID:33011735
Plasma lipid levels and risk of primary open angle glaucoma: a genetic study using Mendelian randomization. PMID:33008364
Exploring the genetic relationship between hearing impairment and Alzheimer's disease. PMID:33005726
The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators. PMID:32997995
Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome. PMID:32996171
The Boulder Workshop Question Box. PMID:32989645
Mendelian randomization study indicates lack of causal relationship between physical activity and lung cancer. PMID:32989605
Higher Fibroblast Growth Factor 23 Levels Are Causally Associated With Lower Bone Mineral Density of Heel and Femoral Neck: Evidence From Two-Sample Mendelian Randomization Analysis. PMID:32984251
Circulating Lipoprotein Lipids, Apolipoproteins and Ischemic Stroke. PMID:32981134
Causal association between mTOR-dependent EIF-4E and EIF-4A circulating protein levels and type 2 diabetes: a Mendelian randomization study. PMID:32978410
Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population. PMID:32975162
Novel Risk Loci in Tinnitus and Causal Inference With Neuropsychiatric Disorders Among Adults of European Ancestry. PMID:32970095
Obesity-Related Traits and the Development of Rheumatoid Arthritis: Evidence From Genetic Data. PMID:32964675
Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality. PMID:32959083
Using Mendelian randomization to understand and develop treatments for neurodegenerative disease. PMID:32954289
Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis. PMID:32949984
Investigating causal relationships between Body Mass Index and risk of atopic dermatitis: a Mendelian randomization analysis. PMID:32943721
Amyloid, tau and risk of Alzheimer's disease: a Mendelian randomization study. PMID:32929646
Complex genetic signatures in immune cells underlie autoimmunity and inform therapy. PMID:32929287
An investigation of causal relationships between prediabetes and vascular complications. PMID:32929089
Deciphering the Plasma Proteome of Type 2 Diabetes. PMID:32928870
Investigation of glycaemic traits in psychiatric disorders using Mendelian randomisation revealed a causal relationship with anorexia nervosa. PMID:32920595
Epigenetic loci for blood pressure are associated with hypertensive target organ damage in older African Americans from the genetic epidemiology network of Arteriopathy (GENOA) study. PMID:32917208
The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study. PMID:32915777
Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization. PMID:32914876
Lipid and metabolic syndrome traits in coronary artery disease: a Mendelian randomization study. PMID:32907989
Human genetic determinants of the gut microbiome and their associations with health and disease: a phenome-wide association study. PMID:32901066
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases. PMID:32895551
Sex-specific genetic effects across biomarkers. PMID:32873964
Morning diurnal preference and food intake: a Mendelian randomization study. PMID:32860398
Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer. PMID:32851660
Association of blood pressure with cognitive function at midlife: a Mendelian randomization study. PMID:32847530
Evaluating Lipid-Lowering Drug Targets for Parkinson's Disease Prevention with Mendelian Randomization. PMID:32841444
A population-based phenome-wide association study of cardiac and aortic structure and function. PMID:32839619
Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes but not coronary artery disease. PMID:32833022
Sleep, major depressive disorder, and Alzheimer disease: A Mendelian randomization study. PMID:32817390
Genetic and functional insights into the fractal structure of the heart. PMID:32814899
Two-Sample Mendelian Randomization Study of Lipid levels and Ischemic Heart Disease. PMID:32812402
Associations of cigarette smoking with psychiatric disorders: evidence from a two-sample Mendelian randomization study. PMID:32796876
Integrative Genomic Analysis Reveals Four Protein Biomarkers for Platelet Traits. PMID:32781905
The shared genetic architecture of schizophrenia, bipolar disorder and lifespan. PMID:32772156
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer. PMID:32769997
Genetic correlation, pleiotropy, and causal associations between substance use and psychiatric disorder. PMID:32762793
Guidelines for performing Mendelian randomization investigations. PMID:32760811
Can increasing years of schooling reduce type 2 diabetes (T2D)?: Evidence from a Mendelian randomization of T2D and 10 of its risk factors. PMID:32737344
Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study. PMID:32737104
Mendelian Randomization Analysis Reveals a Causal Effect of Urinary Sodium/Urinary Creatinine Ratio on Kidney Function in Europeans. PMID:32733862
Desaturase Activity and the Risk of Type 2 Diabetes and Coronary Artery Disease: A Mendelian Randomization Study. PMID:32731631
Altered mechanisms of genital development identified through integration of DNA methylation and genomic measures in hypospadias. PMID:32728162
The relationship between blood metabolites of the tryptophan pathway and kidney function: a bidirectional Mendelian randomization analysis. PMID:32728058
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk. PMID:32724101
Evaluating shared genetic influences on nonsyndromic cleft lip/palate and oropharyngeal neoplasms. PMID:32710482
Polygenic evidence and overlapped brain functional connectivities for the association between chronic pain and sleep disturbance. PMID:32709872
Smoking, alcohol consumption, and cancer: A mendelian randomisation study in UK Biobank and international genetic consortia participants. PMID:32701947
A Mendelian randomization study of telomere length and blood-cell traits. PMID:32699327
Blood DNA methylation sites predict death risk in a longitudinal study of 12, 300 individuals. PMID:32697766
DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes. PMID:32694834
Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice. PMID:32691494
Genetically predicted iron status and life expectancy. PMID:32690432
Causal graphs for the analysis of genetic cohort data. PMID:32687429
Physical activity and risk of Alzheimer disease: A 2-sample mendelian randomization study. PMID:32680943
Multivariate genomic scan implicates novel loci and haem metabolism in human ageing. PMID:32678081
A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease. PMID:32677943
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses. PMID:32665587
Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults. PMID:32641083
Genetic architecture of host proteins interacting with SARS-CoV-2. PMID:32637948
Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis. PMID:32627641
Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer. PMID:32600451
Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes. PMID:32600345
Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies. PMID:32591598
Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain conditions. PMID:32587327
Genome-wide associations of human gut microbiome variation and implications for causal inference analyses. PMID:32572223
IGF-1 and cardiometabolic diseases: a Mendelian randomisation study. PMID:32548700
An Appraisal of the Role of Previously Reported Risk Factors in the Age at Menopause Using Mendelian Randomization. PMID:32547598
Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study. PMID:32547139
Leveraging methylation to identify the potential causal genes associated with survival in lung adenocarcinoma and lung squamous cell carcinoma. PMID:32537022
Impact of sex hormone-binding globulin on the human phenome. PMID:32533189
Smoking and multiple sclerosis risk: a Mendelian randomization study. PMID:32529581
A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness. PMID:32528159
Exploring the causal pathway from body mass index to coronary heart disease: a network Mendelian randomization study. PMID:32523662
Unravelling the complex genetics of common kidney diseases: from variants to mechanisms. PMID:32514149
A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt. PMID:32507850
The contribution of tissue-grouped BMI-associated gene sets to cardiometabolic-disease risk: a Mendelian randomization study. PMID:32500151
Phenotypic and Genetic Characterization of Lower LDL Cholesterol and Increased Type 2 Diabetes Risk in the UK Biobank. PMID:32493714
Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study. PMID:32493226
Studying individual risk factors for self-harm in the UK Biobank: A polygenic scoring and Mendelian randomisation study. PMID:32479557
Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study. PMID:32473944
Higher BMI is linked to an increased risk of heart attacks in European adults: a Mendelian randomisation study. PMID:32471361
Search for multiple myeloma risk factors using Mendelian randomization. PMID:32433745
Quantifying genetic effects on disease mediated by assayed gene expression levels. PMID:32424349
A Two-Sample Mendelian Randomization Analysis Investigates Associations Between Gut Microbiota and Celiac Disease. PMID:32423041
Characterizing the Causal Pathway for Genetic Variants Associated with Neurological Phenotypes Using Human Brain-Derived Proteome Data. PMID:32413284
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. PMID:32385265
Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes. PMID:32385057
Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study. PMID:32376654
Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian randomization study. PMID:32373937
Integrative analysis of Mendelian randomization and Bayesian colocalization highlights four genes with putative BMI-mediated causal pathways to diabetes. PMID:32366963
Appraising the role of circulating concentrations of micro-nutrients in epithelial ovarian cancer risk: A Mendelian randomization analysis. PMID:32355161
Association of Myopia and Intraocular Pressure With Retinal Detachment in European Descent Participants of the UK Biobank Cohort: A Mendelian Randomization Study. PMID:32352494
DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health. PMID:32346601
Early Metabolic Features of Genetic Liability to Type 2 Diabetes: Cohort Study With Repeated Metabolomics Across Early Life. PMID:32345654
Type-2 diabetes and risk of dementia: observational and Mendelian randomisation studies in 1 million individuals. PMID:32326995
Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours. PMID:32317632
Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses. PMID:32310995
Serum Uric Acid Level and Multiple Sclerosis: A Mendelian Randomization Study. PMID:32292418
Examining the effect of smoking on suicidal ideation and attempts: triangulation of epidemiological approaches. PMID:32290872
DNA Methylation and Type 2 Diabetes: the Use of Mendelian Randomization to Assess Causality. PMID:32274260
A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data. PMID:32266232
A multivariable Mendelian randomization to appraise the pleiotropy between intelligence, education, and bipolar disorder in relation to schizophrenia. PMID:32265532
Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration. PMID:32242144
Could vitamin D reduce obesity-associated inflammation? Observational and Mendelian randomization study. PMID:32232398
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis. PMID:32203549
Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations. PMID:32193382
The genetic architecture of the human cerebral cortex. PMID:32193296
Mendelian Randomization Identifies CpG Methylation Sites With Mediation Effects for Genetic Influences on BMD in Peripheral Blood Monocytes. PMID:32180791
Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social support. PMID:32179874
Genetic correlations and causal inferences in ischemic stroke. PMID:32172380
Identification of novel functional CpG-SNPs associated with type 2 diabetes and coronary artery disease. PMID:32162118
Assessment Causality in Associations Between Serum Uric Acid and Risk of Schizophrenia: A Two-Sample Bidirectional Mendelian Randomization Study. PMID:32161502
Empirical comparisons of multiple Mendelian randomization approaches in the presence of assortative mating. PMID:32155257
Shared genetic etiology underlying Alzheimer's disease and major depressive disorder. PMID:32152295
White Blood Cells and Blood Pressure: A Mendelian Randomization Study. PMID:32148083
Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity. PMID:32121467
Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure. PMID:32111823
Circulating Glutamine and Alzheimer's Disease: A Mendelian Randomization Study. PMID:32103921
Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways. PMID:32084330
Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework. PMID:32081875
Age of puberty and Sleep duration: Observational and Mendelian randomization study. PMID:32081851
Plasma lipids and risk of aortic valve stenosis: a Mendelian randomization study. PMID:32076698
Body mass index and height and risk of cutaneous melanoma: Mendelian randomization analyses. PMID:32068838
Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank. PMID:32060260
Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk. PMID:32051193
Power calculation for the general two-sample Mendelian randomization analysis. PMID:32048336
The effect of liver enzymes on body composition: A Mendelian randomization study. PMID:32045441
Mendelian Randomization analysis of the causal effect of adiposity on hospital costs. PMID:32014825
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. PMID:32001714
Functional validity, role, and implications of heavy alcohol consumption genetic loci. PMID:31998841
Glucose-dependent insulinotropic peptide and risk of cardiovascular events and mortality: a prospective study. PMID:31974732
BMI and low vitamin D are causal factors for multiple sclerosis: A Mendelian Randomization study. PMID:31937597
A practical view of fine-mapping and gene prioritization in the post-genome-wide association era. PMID:31937202
Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas. PMID:31932804
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. PMID:31919418
Epigenome-wide association study of seizures in childhood and adolescence. PMID:31915053
Impact of glycemic traits, type 2 diabetes and metformin use on breast and prostate cancer risk: a Mendelian randomization study. PMID:31908803
Using Mendelian randomization to evaluate the causal relationship between serum C-reactive protein levels and age-related macular degeneration. PMID:31900758
A Mendelian randomization analysis of circulating lipid traits and breast cancer risk. PMID:31872213
Bi-directional Mendelian randomization of epithelial ovarian cancer and schizophrenia and uni-directional Mendelian randomization of schizophrenia on circulating 1- or 2-glycerophosphocholine metabolites. PMID:31844628
Use of Mendelian Randomization to Examine Causal Inference in Osteoporosis. PMID:31824424
Exploring the Causal Pathway From Telomere Length to Alzheimer's Disease: An Update Mendelian Randomization Study. PMID:31803085
Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes. PMID:31802129
Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study. PMID:31801993
Causal Associations Between Serum Bilirubin Levels and Decreased Stroke Risk: A Two-Sample Mendelian Randomization Study. PMID:31801373
Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study. PMID:31786776
Educational attainment and drinking behaviors: Mendelian randomization study in UK Biobank. PMID:31768000
Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders. PMID:31766499
The role of haematological traits in risk of ischaemic stroke and its subtypes. PMID:31755939
Comparison of Genetic Liability for Sleep Traits Among Individuals With Bipolar Disorder I or II and Control Participants. PMID:31751445
Genetic evidence for assortative mating on alcohol consumption in the UK Biobank. PMID:31745073
Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization. PMID:31733098
Lipid lowering and Alzheimer disease risk: A mendelian randomization study. PMID:31714636
CAUSALdb: a database for disease/trait causal variants identified using summary statistics of genome-wide association studies. PMID:31691819
Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study. PMID:31689377
Modifiable pathways for colorectal cancer: a mendelian randomisation analysis. PMID:31668584
The role of the retinoids in schizophrenia: genomic and clinical perspectives. PMID:31666680
Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis. PMID:31665421
The Parkinson's Disease Mendelian Randomization Research Portal. PMID:31659794
Approximation of bias and mean-squared error in two-sample Mendelian randomization analyses. PMID:31651042
Body Shape and Alzheimer's Disease: A Mendelian Randomization Analysis. PMID:31649504
Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780,000 participants. PMID:31649322
DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure. PMID:31615550
Informing disease modelling with brain-relevant functional genomic annotations. PMID:31603214
Revisiting the link between platelets and depression through genetic epidemiology: new insights from platelet distribution width. PMID:31601690
Education protects against coronary heart disease and stroke independently of cognitive function: evidence from Mendelian randomization. PMID:31562522
Fifteen years of epidemiology in BMC Medicine. PMID:31543077
Evidence of a Causal Association Between Cancer and Alzheimer's Disease: a Mendelian Randomization Analysis. PMID:31537833
Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease. PMID:31537805
Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health. PMID:31526476
Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study. PMID:31506343
Assessing causal links between metabolic traits, inflammation and schizophrenia: a univariable and multivariable, bidirectional Mendelian-randomization study. PMID:31504541
The effect of birth weight on body composition: Evidence from a birth cohort and a Mendelian randomization study. PMID:31504067
A role for vitamin D and omega-3 fatty acids in major depression? An exploration using genomics. PMID:31488809
Sleep Duration and Myocardial Infarction. PMID:31488267
In search of causal pathways in diabetes: a study using proteomics and genotyping data from a cross-sectional study. PMID:31446444
Major depression and small vessel stroke: a Mendelian randomization analysis. PMID:31435769
The genetic relationship between female reproductive traits and six psychiatric disorders. PMID:31427629
Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease. PMID:31424985
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. PMID:31409809
Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese Adults. PMID:31399431
Childhood obesity leads to adult type 2 diabetes and coronary artery diseases: A 2-sample mendelian randomization study. PMID:31393416
Health effects associated with serum calcium concentrations: evidence from MR-PheWAS analysis in UK Biobank. PMID:31392400
Appraising the role of previously reported risk factors in epithelial ovarian cancer risk: A Mendelian randomization analysis. PMID:31390370
Current opportunities to catalyze research in nutrition and cancer prevention - an interdisciplinary perspective. PMID:31357989
Causal Association Between Birth Weight and Adult Diseases: Evidence From a Mendelian Randomization Analysis. PMID:31354785
Phenome-wide Burden of Copy-Number Variation in the UK Biobank. PMID:31353025
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. PMID:31341166
Availability of public databases for triangulation of findings. PMID:31337685
Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight. PMID:31335958
Repurposing antihypertensive drugs for the prevention of Alzheimer's disease: a Mendelian randomization study. PMID:31335937
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936. PMID:31320639
The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study. PMID:31309263
Genetically-predicted life-long lowering of low-density lipoprotein cholesterol is associated with decreased frailty: A Mendelian randomization study in UK biobank. PMID:31300347
Epigenome-wide association study of DNA methylation and microRNA expression highlights novel pathways for human complex traits. PMID:31282290
Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease. PMID:31276585
Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour. PMID:31270314
DNA methylation links prenatal smoking exposure to later life health outcomes in offspring. PMID:31262328
An integrative approach to detect epigenetic mechanisms that putatively mediate the influence of lifestyle exposures on disease susceptibility. PMID:31257439
Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease: A Mendelian randomization study. PMID:31253830
The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis. PMID:31243447
Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study. PMID:31243001
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration. PMID:31226389
Associations of genetically determined iron status across the phenome: A mendelian randomization study. PMID:31220083
Reproduction and longevity: A Mendelian randomization study of gonadotropin-releasing hormone and ischemic heart disease. PMID:31198836
Genome-wide association study of breakfast skipping links clock regulation with food timing. PMID:31190057
Genetic correlations of polygenic disease traits: from theory to practice. PMID:31171865
Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures. PMID:31170332
The impact of GDF-15, a biomarker for metformin, on the risk of coronary artery disease, breast and colorectal cancer, and type 2 diabetes and metabolic traits: a Mendelian randomisation study. PMID:31161347
Epidemiology, genetic epidemiology and Mendelian randomisation: more need than ever to attend to detail. PMID:31134333
Causal Effects of Genetically Predicted Cardiovascular Risk Factors on Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study. PMID:31130989
Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study. PMID:31122926
The Association between Habitual Sleep Duration and Sleep Quality with Glycemic Traits: Assessment by Cross-Sectional and Mendelian Randomization Analyses. PMID:31096629
Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study. PMID:31088856
Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease. PMID:31075152
Epigenome-wide association study of lung function level and its change. PMID:31073081
Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease. PMID:31070104
Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study. PMID:31050786
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. PMID:31015461
Assessing causality in the association between attention-deficit/hyperactivity disorder and obesity: a Mendelian randomization study. PMID:31000774
Varicose veins of lower extremities: Insights from the first large-scale genetic study. PMID:30998689
Assessing the Role of Selenium in Endometrial Cancer Risk: A Mendelian Randomization Study. PMID:30972295
Insulin resistance: Genetic associations with depression and cognition in population based cohorts. PMID:30965038
Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium. PMID:30929657
Diabetes and cancer risk: A Mendelian randomization study. PMID:30927373
Meta-analysis and Mendelian randomization: A review. PMID:30861319
Genetic Evidence for the Association between Schizophrenia and Breast Cancer. PMID:30854469
Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. PMID:30846698
An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome. PMID:30835202
Using Openly Accessible Resources to Strengthen Causal Inference in Epigenetic Epidemiology of Neurodevelopment and Mental Health. PMID:30832291
The Genetic Sphygmomanometer: an argument for routine genome-wide genotyping in the population and a new view on its use to inform clinical practice. PMID:30828643
Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization. PMID:30815700
Biological and clinical insights from genetics of insomnia symptoms. PMID:30804566
Lean mass, grip strength and risk of type 2 diabetes: a bi-directional Mendelian randomisation study. PMID:30798333
"Mendelian Randomization" Approach in Economic Assessment of Health Conditions. PMID:30778381
Mineral Nutrition and the Risk of Chronic Diseases: A Mendelian Randomization Study. PMID:30759836
Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study. PMID:30741477
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. PMID:30718901
Mendelian randomisation: A powerful and inexpensive method for identifying and excluding non-genetic risk factors for colorectal cancer. PMID:30710596
Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization. PMID:30704512
Investigating the causal relationship between neuroticism and depression via Mendelian randomization. PMID:30697695
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. PMID:30696823
LDL triglycerides, hepatic lipase activity, and coronary artery disease: An epidemiologic and Mendelian randomization study. PMID:30685440
Mendelian randomization provides support for obesity as a risk factor for meningioma. PMID:30670737
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. PMID:30664745
Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis. PMID:30659178
Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents: A Voxelwise and Genome-Wide Association Study. PMID:30649180
Variation in Serum PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9), Cardiovascular Disease Risk, and an Investigation of Potential Unanticipated Effects of PCSK9 Inhibition. PMID:30645169
Conducting a Reproducible Mendelian Randomization Analysis Using the R Analytic Statistical Environment. PMID:30645041
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances. PMID:30642433
Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip/palate. PMID:30638414
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. PMID:30617275
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies. PMID:30604766
Polygenic risk score increases schizophrenia liability through cognition-relevant pathways. PMID:30535067
GWAS identifies 14 loci for device-measured physical activity and sleep duration. PMID:30531941
A Transethnic Mendelian Randomization Study Identifies Causality of Obesity on Risk of Psoriasis. PMID:30528826
Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome. PMID:30496407
Use of Mendelian Randomization for Identifying Risk Factors for Brain Tumors. PMID:30483309
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. PMID:30388399
Mendelian randomization does not support serum calcium in prostate cancer risk. PMID:30306355
Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain. PMID:30261039
Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study. PMID:30254091
Age at menarche and osteoporosis: A Mendelian randomization study. PMID:30240960
Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure. PMID:30220432
Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization-A Job for the Humble Heterogeneity Statistic? PMID:30188969
PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics. PMID:30165448
Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study. PMID:30153260
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease. PMID:30111768
Glucose and Insulin-Related Traits, Type 2 Diabetes and Risk of Schizophrenia: A Mendelian Randomization Study. PMID:30100396
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. PMID:30002074
Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease. PMID:29893838
Variation in Interleukin 6 Receptor Gene Associates With Risk of Crohn's Disease and Ulcerative Colitis. PMID:29775600
Evaluating the potential role of pleiotropy in Mendelian randomization studies. PMID:29771313 -
Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes
PubMed citations: 18.
18 articles citing: Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes
Causal effect of atrial fibrillation/flutter on chronic kidney disease: A bidirectional two-sample Mendelian randomization study. PMID:34898631
Matrix Metalloproteinases in Relation to Bone Mineral Density: A Two-Sample Mendelian Randomization Study. PMID:34868227
Estimating causal effects of atherogenic lipid-related traits on COVID-19 susceptibility and severity using a two-sample Mendelian randomization approach. PMID:34774031
Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. PMID:34675202
Joint Analysis of Genome-Wide Association Data Reveals No Genetic Correlations Between Low Back Pain and Neurodegenerative Diseases. PMID:34630533
Growth Differentiation Factor 15 Is Associated With Alzheimer's Disease Risk. PMID:34484296
Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study. PMID:34150709
Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study. PMID:34061844
Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes. PMID:34051439
Does Chronic Intestinal Inflammation Promote Atrial Fibrillation: A Mendelian Randomization Study With Populations of European Ancestry. PMID:34041279
Mendelian randomization as an approach to assess causal effects of inflammatory bowel disease on atrial fibrillation. PMID:33824227
Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis. PMID:33661905
A Systematic Two-Sample Mendelian Randomization Analysis Identifies Shared Genetic Origin of Endometriosis and Associated Phenotypes. PMID:33401535
The effect of angiotensin-converting enzyme levels on COVID-19 susceptibility and severity: a Mendelian randomization study. PMID:33349849
Genomic Medicine: Lessons Learned From Monogenic and Complex Bone Disorders. PMID:33162933
Causal association between mTOR-dependent EIF-4E and EIF-4A circulating protein levels and type 2 diabetes: a Mendelian randomization study. PMID:32978410
The role of testosterone in chronic kidney disease and kidney function in men and women: a bi-directional Mendelian randomization study in the UK Biobank. PMID:32493397
Shared genetic etiology underlying Alzheimer's disease and major depressive disorder. PMID:32152295
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gwas study
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:06.589756
genotype and phenotype
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:06.589756
small molecules
metasource: bio.tools
version: extracted_at: 2022-11-04T11:24:06.589756
Tags
More detailed information about this field from each metasource.
gwas study
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:24:06.589756
genotype and phenotype
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:24:06.589756
small molecules
metasource: bio.toolsversion: extracted_at: 2022-11-04T11:24:06.589756
gwas study genotype and phenotype small molecule
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