R33225 last accessed: 2022-11-04

metasource: bio.tools
version: extracted_at: 2022-11-04T11:35:58.540987

merops
metasource: bio.tools
version: extracted_at: 2022-11-04T11:35:58.540987

Other names: merops

The MEROPS database is an information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

Webpage:

http://www.ebi.ac.uk/merops/

Licence:

Name: other
URL: https://www.ebi.ac.uk/about/terms-of-use

Publications: (9)

Publications
More detailed information about this field from each metasource.

The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database
PMID: 29145643
metasource: Fairsharing.org
version: FAIRsharing.org: MEROPS; MEROPS; DOI: https://doi.org/10.25504/FAIRsharing.2s4n8r; Last edited: April 26, 2021, 2:59 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors
PMID: 22086950
metasource: Fairsharing.org
version: FAIRsharing.org: MEROPS; MEROPS; DOI: https://doi.org/10.25504/FAIRsharing.2s4n8r; Last edited: April 26, 2021, 2:59 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

metasource: bio.tools
version: extracted_at: 2022-11-04T11:35:58.540987

MEROPS: the peptidase database
PMID: 19892822
metasource: bio.tools
version: extracted_at: 2022-11-04T11:35:58.540987

Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors
PMID: 26527717
metasource: Fairsharing.org
version: FAIRsharing.org: MEROPS; MEROPS; DOI: https://doi.org/10.25504/FAIRsharing.2s4n8r; Last edited: April 26, 2021, 2:59 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

MEROPS: the peptidase database
PMID: 17991683
metasource: Fairsharing.org
version: FAIRsharing.org: MEROPS; MEROPS; DOI: https://doi.org/10.25504/FAIRsharing.2s4n8r; Last edited: April 26, 2021, 2:59 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

Evolutionary families of peptidases
PMID: 8439290
metasource: Fairsharing.org
version: FAIRsharing.org: MEROPS; MEROPS; DOI: https://doi.org/10.25504/FAIRsharing.2s4n8r; Last edited: April 26, 2021, 2:59 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

MEROPS: the peptidase database
PMID: 9847218
metasource: Fairsharing.org
version: FAIRsharing.org: MEROPS; MEROPS; DOI: https://doi.org/10.25504/FAIRsharing.2s4n8r; Last edited: April 26, 2021, 2:59 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

Peptidase specificity from the substrate cleavage collection in the MEROPS database and a tool to measure cleavage site conservation
PMID: 26455268
metasource: Fairsharing.org
version: FAIRsharing.org: MEROPS; MEROPS; DOI: https://doi.org/10.25504/FAIRsharing.2s4n8r; Last edited: April 26, 2021, 2:59 p.m.; Last accessed: Jan 03 2022 7:06 p.m.

http://dx.doi.org/10.1093/nar/gkx1134
metasource: Nucleic Acid Research database catalogue
version: extracted_at: 2022-11-04T11:16:25.468657

The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database PubMed citations: 394.

394 articles citing: The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database

Discovery of Leishmania Druggable Serine Proteases by Activity-Based Protein Profiling. PMID:35910377
Purification and Characterization of a Novel Extracellular Haloprotease Vpr from Bacillus licheniformis Strain KB111. PMID:35910276
Transcriptome Analysis Reveals Early Hemocyte Responses upon In Vivo Stimulation with LPS in the Stick Insect Bacillus rossius (Rossi, 1788). PMID:35886821
Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut. PMID:35882872
Probing the Conformational States of Thimet Oligopeptidase in Solution. PMID:35806299
A cryptic third active site in cyanophycin synthetase creates primers for polymerization. PMID:35798723
The Evolutionary History of Peptidases Involved in the Processing of Organelle-Targeting Peptides. PMID:35758251
Aspartyl Protease Inhibitors as Anti-Filarial Drugs. PMID:35745561
Evolution of host protease interactions among SARS-CoV-2 variants of concern and related coronaviruses. PMID:35734085
Phage-Related Ribosomal Protease (Prp) of Staphylococcus aureus: In Vitro Michaelis-Menten Kinetics, Screening for Inhibitors, and Crystal Structure of a Covalent Inhibition Product Complex. PMID:35731716
Transcriptomic and proteomic profiling of peptidase expression in Fasciola hepatica eggs developing at host's body temperature. PMID:35725898
Doxycycline Alters the Porcine Renal Proteome and Degradome during Hypothermic Machine Perfusion. PMID:35723325
Genome Wide Identification and Expression Profiling Indicate Expansion of Family I84 Protease Inhibitor via Gene Tandem Duplication and Divergence in Razor Clam Sinonovacula constricta. PMID:35720365
Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma. PMID:35716777
In-depth comparative analysis of Tritrichomonas foetus transcriptomics reveals novel genes linked with adaptation to feline host. PMID:35710931
Deep Learning-Based Advances In Protein Posttranslational Modification Site and Protein Cleavage Prediction. PMID:35696087
Smaller, Stronger, More Stable: Peptide Variants of a SARS-CoV-2 Neutralizing Miniprotein. PMID:35682988
Post-Proline Cleaving Enzymes (PPCEs): Classification, Structure, Molecular Properties, and Applications. PMID:35631755
Activity-Based Probes for Proteases Pave the Way to Theranostic Applications. PMID:35631563
Competence shut-off by intracellular pheromone degradation in salivarius streptococci. PMID:35613247
Survey of Dipeptidyl Peptidase III Inhibitors: From Small Molecules of Microbial or Synthetic Origin to Aprotinin. PMID:35566358
Plant Kunitz Inhibitors and Their Interaction with Proteases: Current and Potential Pharmacological Targets. PMID:35563133
Evolutionary Diversity and Function of Metacaspases in Plants: Similar to but Not Caspases. PMID:35562978
Bacterial matrix metalloproteases and serine proteases contribute to the extra-host inactivation of enteroviruses in lake water. PMID:35545659
Broad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme. PMID:35510806
Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome. PMID:35484230
Tissue remodeling by an opportunistic pathogen triggers allergic inflammation. PMID:35483356
S51 Family Peptidases Provide Resistance to Peptidyl-Nucleotide Antibiotic McC. PMID:35467414
2-Pyridine Carboxaldehyde for Semi-Automated Soft Spot Identification in Cyclic Peptides. PMID:35457087
An Apoplastic Effector Pat-1Cm of the Gram-Positive Bacterium Clavibacter michiganensis Acts as Both a Pathogenicity Factor and an Immunity Elicitor in Plants. PMID:35432427
Pepsin-like aspartic proteases (PAPs) as model systems for combining biomolecular simulation with biophysical experiments. PMID:35423571
Genomic Insights into the Distribution of Peptidases and Proteolytic Capacity among Prevotella and Paraprevotella Species. PMID:35377228
Proteomic Analysis of Embryo Isolated From Mature Jatropha curcas L. Seeds. PMID:35371174
Contribution of proteases to the hallmarks of aging and to age-related neurodegeneration. PMID:35349763
Non-Apoptotic Caspase Activity Preferentially Targets a Novel Consensus Sequence Associated With Cytoskeletal Proteins in the Developing Auditory Brainstem. PMID:35330912
Cleavage of LOXL1 by BMP1 and ADAMTS14 Proteases Suggests a Role for Proteolytic Processing in the Regulation of LOXL1 Function. PMID:35328709
The Genome of Rhyzopertha dominica (Fab.) (Coleoptera: Bostrichidae): Adaptation for Success. PMID:35328000
Identification of key microorganisms in facultative stabilization ponds from dairy industries, using metagenomics. PMID:35310160
Impact of poly-arginine peptides R18D and R18 on alteplase and tenecteplase thrombolysis in vitro, and neuroprotective stability to proteolysis. PMID:35305237
Transcriptional Profiles of a Foliar Fungal Endophyte (Pestalotiopsis, Ascomycota) and Its Bacterial Symbiont (Luteibacter, Gammaproteobacteria) Reveal Sulfur Exchange and Growth Regulation during Early Phases of Symbiotic Interaction. PMID:35293790
Mechanistic Insight into the Fragmentation of Type I Collagen Fibers into Peptides and Amino Acids by a Vibrio Collagenase. PMID:35285716
Microbial Diversity and Sulfur Cycling in an Early Earth Analogue: From Ancient Novelty to Modern Commonality. PMID:35258328
Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. PMID:35247328
Considerations for constructing a protein sequence database for metaproteomics. PMID:35242286
The novel genus, 'Candidatus Phosphoribacter', previously identified as Tetrasphaera, is the dominant polyphosphate accumulating lineage in EBPR wastewater treatment plants worldwide. PMID:35217776
Genome-Wide Analyses of Aspartic Proteases on Potato Genome (Solanum tuberosum): Generating New Tools to Improve the Resistance of Plants to Abiotic Stress. PMID:35214878
An Introduction to Bacterial Biofilms and Their Proteases, and Their Roles in Host Infection and Immune Evasion. PMID:35204806
Low-level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus. PMID:35203107
The structure of the Clostridium thermocellum RsgI9 ectodomain provides insight into the mechanism of biomass sensing. PMID:35194841
Protease activities of vaginal Porphyromonas species disrupt coagulation and extracellular matrix in the cervicovaginal niche. PMID:35190575
Niche partitioning of the ubiquitous and ecologically relevant NS5 marine group. PMID:35169264
Fusarium graminearum Infection Strategy in Wheat Involves a Highly Conserved Genetic Program That Controls the Expression of a Core Effectome. PMID:35163834
Evolutionary Analysis of Dipeptidyl Peptidase I. PMID:35163774
Cryptococcal Protease(s) and the Activation of SARS-CoV-2 Spike (S) Protein. PMID:35159253
Validating Cell Surface Proteases as Drug Targets for Cancer Therapy: What Do We Know, and Where Do We Go? PMID:35158891
A large accessory genome and high recombination rates may influence global distribution and broad host range of the fungal plant pathogen Claviceps purpurea. PMID:35143550
The genome of the Paleogene relic tree Bretschneidera sinensis: insights into trade-offs in gene family evolution, demographic history, and adaptive SNPs. PMID:35137004
Response and resilience of anammox consortia to nutrient starvation. PMID:35105385
Proteases as Therapeutic Targets Against the Parasitic Cnidarian Ceratonova shasta: Characterization of Molecules Key to Parasite Virulence In Salmonid Hosts. PMID:35071050
Lysosomal peptidases-intriguing roles in cancer progression and neurodegeneration. PMID:35067006
Characterization and heterologous expression of a novel Co2+-dependent leucyl aminopeptidase Amp0279 originating from Lysinibacillus sphaericus. PMID:35064357
Genomic insights into versatile lifestyle of three new bacterial candidate phyla. PMID:35060074
Urine peptidome in combination with transcriptomics analysis highlights MMP7, MMP14 and PCSK5 for further investigation in chronic kidney disease. PMID:35045102
Comparative transcriptome profiles of Schistosoma japonicum larval stages: Implications for parasite biology and host invasion. PMID:35025881
Insight into the symbiotic lifestyle of DPANN archaea revealed by cultivation and genome analyses. PMID:35022241
Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases. PMID:35011288
Fibroblast Activation Protein (FAP) targeting homodimeric FAP inhibitor radiotheranostics: a step to improve tumor uptake and retention time. PMID:35003886
Plant cell responses to allelopathy: from oxidative stress to programmed cell death. PMID:34993622
Factor IX(a) inhibitors: an updated patent review (2003-present). PMID:34991418
7-Aminocoumarin-4-acetic Acid as a Fluorescent Probe for Detecting Bacterial Dipeptidyl Peptidase Activities in Water-in-Oil Droplets and in Bulk. PMID:34963280
From Naturally-Sourced Protease Inhibitors to New Treatments for Fungal Infections. PMID:34946998
New Insights into the Role of Cysteine Cathepsins in Neuroinflammation. PMID:34944440
Making the cut with protease engineering. PMID:34921772
Multimeric Association of Purified Novel Bowman-Birk Inhibitor From the Medicinal Forage Legume Mucuna pruriens (L.) DC. PMID:34899797
A plant-biotechnology approach for producing highly potent anti-HIV antibodies for antiretroviral therapy consideration. PMID:34878628
Involvement of ClpE ATPase in Physiology of Streptococcus mutans. PMID:34851151
Engineering Approaches in Plant Molecular Farming for Global Health. PMID:34835201
The Angiostrongylus vasorum Excretory/Secretory and Surface Proteome Contains Putative Modulators of the Host Coagulation. PMID:34796127
Telomere-to-telomere genome assembly of asparaginase-producing Trichoderma simmonsii. PMID:34789157
Cloning, expression and characterization of metalloproteinase HypZn from Aspergillus niger. PMID:34762700
The transposable element-rich genome of the cereal pest Sitophilus oryzae. PMID:34749730
A Novel Rice Curl Dwarf-Associated Picornavirus Encodes a 3C Serine Protease Recognizing Uncommon EPT/S Cleavage Sites. PMID:34721366
Allosteric Regulation of 3CL Protease of SARS-CoV-2 and SARS-CoV Observed in the Crystal Structure Ensemble. PMID:34717972
Multipotential Alkaline Protease From a Novel Pyxidicoccus sp. 252: Ecofriendly Replacement to Various Chemical Processes. PMID:34707581
The fungal root endophyte Serendipita vermifera displays inter-kingdom synergistic beneficial effects with the microbiota in Arabidopsis thaliana and barley. PMID:34686763
First Crystal Structure of Bacterial Oligopeptidase B in an Intermediate State: The Roles of the Hinge Region Modification and Spermine. PMID:34681120
The Possible Role of Microbial Proteases in Facilitating SARS-CoV-2 Brain Invasion. PMID:34681064
Gene Analysis, Cloning, and Heterologous Expression of Protease from a Micromycete Aspergillus ochraceus Capable of Activating Protein C of Blood Plasma. PMID:34576831
A new carboxypeptidase from Aspergillus niger with good thermostability, pH stability and broad substrate specificity. PMID:34548523
Genomes of Novel Myxococcota Reveal Severely Curtailed Machineries for Predation and Cellular Differentiation. PMID:34524899
Microbial proteases: ubiquitous enzymes with innumerable uses. PMID:34513551
Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement. PMID:34502392
Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase. PMID:34500777
Verrucomicrobiota are specialist consumers of sulfated methyl pentoses during diatom blooms. PMID:34493810
Comparative genomic analysis reveals metabolic flexibility of Woesearchaeota. PMID:34489402
Comparative Genomic Analysis Reveals Genetic Variation and Adaptive Evolution in the Pathogenicity-Related Genes of Phytophthora capsici. PMID:34484141
Edge-strand of BepA interacts with immature LptD on the β-barrel assembly machine to direct it to on- and off-pathways. PMID:34463613
The dataset of predicted trypsin serine peptidases and their inactive homologs in Tenebrio molitor transcriptomes. PMID:34458527
Whole genome sequences of two Trichophyton indotineae clinical isolates from India emerging as threats during therapeutic treatment of dermatophytosis. PMID:34458064
Next-Generation Sequencing Analysis of the Tineola bisselliella Larval Gut Transcriptome Reveals Candidate Enzymes for Keratin Digestion. PMID:34440287
Activity of Lymphostatin, A Lymphocyte Inhibitory Virulence Factor of Pathogenic Escherichia coli, is Dependent on a Cysteine Protease Motif. PMID:34400181
Increased abundance of secreted hydrolytic enzymes and secondary metabolite gene clusters define the genomes of latent plant pathogens in the Botryosphaeriaceae. PMID:34348651
Proteases Regulate Cancer Stem Cell Properties and Remodel Their Microenvironment. PMID:34310223
PNPLA3 and TLL-1 Polymorphisms as Potential Predictors of Disease Severity in Patients With COVID-19. PMID:34249902
Repurposing proteases: An in-silico analysis of the binding potential of extracellular fungal proteases with selected viral proteins. PMID:34226889
The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases. PMID:34226511
Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia. PMID:34210221
Genomic Characteristics and Comparative Genomics Analysis of Two Chinese Corynespora cassiicola Strains Causing Corynespora Leaf Fall (CLF) Disease. PMID:34208763
Carboxy-Terminal Processing Protease Controls Production of Outer Membrane Vesicles and Biofilm in Acinetobacter baumannii. PMID:34203028
In Vitro Evaluation of the Squaramide-Conjugated Fibroblast Activation Protein Inhibitor-Based Agents AAZTA5.SA.FAPi and DOTA.SA.FAPi. PMID:34201111
Comparative Genomics of Eight Fusarium graminearum Strains with Contrasting Aggressiveness Reveals an Expanded Open Pangenome and Extended Effector Content Signatures. PMID:34200775
Coumarin Derivatives Act as Novel Inhibitors of Human Dipeptidyl Peptidase III: Combined In Vitro and In Silico Study. PMID:34198854
Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. PMID:34189422
Insights into the phylogeny and transcriptional response of serine proteases in a halotolerant cyanobacterium Halothece sp. PCC7418. PMID:34184613
Plant protease as regulator and signaling molecule for enhancing environmental stress-tolerance. PMID:34173047
Microbiomes attached to fresh perennial ryegrass are temporally resilient and adapt to changing ecological niches. PMID:34154659
CRISPR-Cas9 Editing of Human Histone Deubiquitinase Gene USP16 in Human Monocytic Leukemia Cell Line THP-1. PMID:34136489
Degradation of biological macromolecules supports uncultured microbial populations in Guaymas Basin hydrothermal sediments. PMID:34112968
A Suite of Activity-Based Probes To Dissect the KLK Activome in Drug-Resistant Prostate Cancer. PMID:34085829
Mining the Biomarker Potential of the Urine Peptidome: From Amino Acids Properties to Proteases. PMID:34073067
What the Wild Things Do: Mechanisms of Plant Host Manipulation by Bacterial Type III-Secreted Effector Proteins. PMID:34064647
An Integrative Bioinformatic Analysis for Keratinase Detection in Marine-Derived Streptomyces. PMID:34063876
High-Quality Reference Genome Sequence for the Oomycete Vegetable Pathogen Phytophthora capsici Strain LT1534. PMID:34042486
Draft Genome Sequences of Five Fungal Strains Isolated from Kefir. PMID:34042484
Arginine substitution by alanine at the P1 position increases the selectivity of CmPI-II, a non-classical Kazal inhibitor. PMID:34027134
Genomics, Exometabolomics, and Metabolic Probing Reveal Conserved Proteolytic Metabolism of Thermoflexus hugenholtzii and Three Candidate Species From China and Japan. PMID:34017316
In Vitro and In Situ Activity-Based Labeling of Fibroblast Activation Protein with UAMC1110-Derived Probes. PMID:33996747
Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity. PMID:33970782
The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area. PMID:33953672
DpaA Detaches Braun's Lipoprotein from Peptidoglycan. PMID:33947763
Microbial iron and carbon metabolism as revealed by taxonomy-specific functional diversity in the Southern Ocean. PMID:33941887
The role of calcium-sensing receptor signaling in regulating transepithelial calcium transport. PMID:33926258
Coexistence of SOS-Dependent and SOS-Independent Regulation of DNA Repair Genes in Radiation-Resistant Deinococcus Bacteria. PMID:33923690
Unraveling the Metabolic Potential of Asgardarchaeota in a Sediment from the Mediterranean Hydrocarbon-Contaminated Water Basin Mar Piccolo (Taranto, Italy). PMID:33923677
First Description of the Composition and the Functional Capabilities of the Skin Microbial Community Accompanying Severe Scabies Infestation in Humans. PMID:33922793
Cystatin M/E (Cystatin 6): A Janus-Faced Cysteine Protease Inhibitor with Both Tumor-Suppressing and Tumor-Promoting Functions. PMID:33919854
Phylogenomic Insights into Distribution and Adaptation of Bdellovibrionota in Marine Waters. PMID:33916768
Mammalian Neuropeptides as Modulators of Microbial Infections: Their Dual Role in Defense versus Virulence and Pathogenesis. PMID:33915818
Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria. PMID:33909410
Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7. PMID:33846449
Gluten-degrading bacteria: availability and applications. PMID:33837830
Externally added cystatin C reduces growth of A375 melanoma cells by increasing cell cycle time. PMID:33837649
Poplar protease inhibitor expression differs in an herbivore specific manner. PMID:33836664
A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. PMID:33827210
Insight into the human pathodegradome of the V8 protease from Staphylococcus aureus. PMID:33826899
Microbiota, renal disease and renal transplantation. PMID:33816144
PepFun: Open Source Protocols for Peptide-Related Computational Analysis. PMID:33809815
Predicting Proteolysis in Complex Proteomes Using Deep Learning. PMID:33803033
The Tumor Proteolytic Landscape: A Challenging Frontier in Cancer Diagnosis and Therapy. PMID:33802262
Exploring the landscape of ectodomain shedding by quantitative protein terminomics. PMID:33796845
Characterization and Diversity Analysis of the Extracellular Proteases of Thermophilic Anoxybacillus caldiproteolyticus 1A02591 From Deep-Sea Hydrothermal Vent Sediment. PMID:33796092
Building blocks and blueprints for bacterial autolysins. PMID:33793553
Potential New Treatments for Kawasaki Disease, Its Variations, and Multisystem Inflammatory Syndrome. PMID:33786417
Taxonomic and Enzymatic Characterization of Flocculibacter collagenilyticus gen. nov., sp. nov., a Novel Gammaproteobacterium With High Collagenase Production. PMID:33786038
Two-step functional screen on multiple proteinaceous substrates reveals temperature-robust proteases with a broad-substrate range. PMID:33770243
Extensive structural variation in the Bowman-Birk inhibitor family in common wheat (Triticum aestivum L.). PMID:33765923
Ancient gene duplications in RNA viruses revealed by protein tertiary structure comparisons. PMID:33758672
Inhibition of bacterial and human zinc-metalloproteases by bisphosphonate- and catechol-containing compounds. PMID:33757387
A first insight into the genome of Prototheca wickerhamii, a major causative agent of human protothecosis. PMID:33750287
Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen. PMID:33727531
Variability in digestive and respiratory tract Ace2 expression is associated with the microbiome. PMID:33725024
Predicted Input of Uncultured Fungal Symbionts to a Lichen Symbiosis from Metagenome-Assembled Genomes. PMID:33693712
Characterization of a pericentric inversion in plateau fence lizards (Sceloporus tristichus): evidence from chromosome-scale genomes. PMID:33693605
Papain-like cysteine proteases are required for the regulation of photosynthetic gene expression and acclimation to high light stress. PMID:33686435
Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs. PMID:33672235
Mining oomycete proteomes for metalloproteases leads to identification of candidate virulence factors in Phytophthora infestans. PMID:33657266
Predicting the zoonotic capacity of mammals to transmit SARS-CoV-2. PMID:33619481
Quantitative profiling of protease specificity. PMID:33617527
Bioinformatic Analysis of the Wound Peptidome Reveals Potential Biomarkers and Antimicrobial Peptides. PMID:33613550
Metagenomic Insights into the Metabolic and Ecological Functions of Abundant Deep-Sea Hydrothermal Vent DPANN Archaea. PMID:33608296
"Sifarchaeota," a Novel Asgard Phylum from Costa Rican Sediment Capable of Polysaccharide Degradation and Anaerobic Methylotrophy. PMID:33608286
A High-Quality Reference Genome for a Parasitic Bivalve with Doubly Uniparental Inheritance (Bivalvia: Unionida). PMID:33570560
SARS-CoV-2 mutation 614G creates an elastase cleavage site enhancing its spread in high AAT-deficient regions. PMID:33556558
Evolutionary Analysis of Cystatins of Early-Emerging Metazoans Reveals a Novel Subtype in Parasitic Cnidarians. PMID:33546310
Mapping proteolytic neo-N termini at the surface of living cells. PMID:33536314
Characterization of the Temporal Pattern of Blood Protein Digestion in Rhodnius prolixus: First Description of Early and Late Gut Cathepsins. PMID:33519496
Mechanisms Applied by Protein Inhibitors to Inhibit Cysteine Proteases. PMID:33498210
Comparative transcriptomics and host-specific parasite gene expression profiles inform on drivers of proliferative kidney disease. PMID:33495500
DUB esterase activity further decodes ubiquitin's enigma. PMID:33495366
Defense and Offense Strategies: The Role of Aspartic Proteases in Plant-Pathogen Interactions. PMID:33494266
Peeling the Layers Away: The Genomic Characterization of Bacillus pumilus 64-1, an Isolate With Antimicrobial Activity From the Marine Sponge Plakina cyanorosea (Porifera, Homoscleromorpha). PMID:33488540
Insights into the Role of Tick Salivary Protease Inhibitors during Ectoparasite-Host Crosstalk. PMID:33477394
The Thyroid Hormone Transporter Mct8 Restricts Cathepsin-Mediated Thyroglobulin Processing in Male Mice through Thyroid Auto-Regulatory Mechanisms That Encompass Autophagy. PMID:33466458
Bioinformatic mapping of a more precise Aspergillus niger degradome. PMID:33436802
Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond. PMID:33425918
Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens? PMID:33411319
An automated protocol for modelling peptide substrates to proteases. PMID:33375946
Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of 'Papain Superfamily' Cysteine Proteases. PMID:33374547
Apoplastic Proteases: Powerful Weapons against Pathogen Infection in Plants. PMID:33367249
Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design. PMID:33352765
Serum Proteomics Reveals Alterations in Protease Activity, Axon Guidance, and Visual Phototransduction Pathways in Infants With In Utero Exposure to Zika Virus Without Congenital Zika Syndrome. PMID:33312964
Comparative proteomics of common allergenic tree pollens of birch, alder, and hazel. PMID:33301602
In-depth secretome analysis of Puccinia striiformis f. sp. tritici in infected wheat uncovers effector functions. PMID:33275764
Biotechnological Potential of Araucaria angustifolia Pine Nuts Extract and the Cysteine Protease Inhibitor AaCI-2S. PMID:33266031
Bowman-Birk Inhibitors: Insights into Family of Multifunctional Proteins and Peptides with Potential Therapeutical Applications. PMID:33255583
Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease. PMID:33247098
Effects of Excess Manganese on the Xylem Sap Protein Profile of Tomato (Solanum lycopersicum) as Revealed by Shotgun Proteomic Analysis. PMID:33238539
Purification and Biochemical Characterization of a New Protease Inhibitor from Conyza dioscoridis with Antimicrobial, Antifungal and Cytotoxic Effects. PMID:33233753
Mass Spectrometric Characterization of Histone H3 Isolated from in-Vitro Reconstituted and Acetylated Nucleosome Core Particle. PMID:33224699
To be there when the picture is being painted. PMID:33219166
Abundance of metalloprotease FtsH12 modulates chloroplast development in Arabidopsis thaliana. PMID:33216923
New Glutamine-Containing Substrates for the Assay of Cysteine Peptidases From the C1 Papain Family. PMID:33195423
Metagenomic and Metatranscriptomic Analyses Revealed Uncultured Bacteroidales Populations as the Dominant Proteolytic Amino Acid Degraders in Anaerobic Digesters. PMID:33193263
Quorum-Sensing Regulator OpaR Directly Represses Seven Protease Genes in Vibrio parahaemolyticus. PMID:33193123
Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection. PMID:33185526
Impact of Fermentable Protein, by Feeding High Protein Diets, on Microbial Composition, Microbial Catabolic Activity, Gut Health and beyond in Pigs. PMID:33167470
Identification and characterization of the proteolytic flagellin from the common freshwater bacterium Hylemonella gracilis. PMID:33149258
β-Lytic Protease of Lysobacter capsici VKM B-2533T. PMID:33126447
Pfam: The protein families database in 2021. PMID:33125078
PhycoCosm, a comparative algal genomics resource. PMID:33104790
Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation. PMID:33095259
Reversible autoinhibitory regulation of Escherichia coli metallopeptidase BepA for selective β-barrel protein degradation. PMID:33093205
A Kunitz-type peptide from Dendroaspis polylepis venom as a simultaneous inhibitor of serine and cysteine proteases. PMID:33088285
Differential Transcription and Alternative Splicing in Cotton Underly Specialized Defense Responses Against Pests. PMID:33072149
Genetic Diversity of Serine Protease Inhibitors in Myxozoan (Cnidaria, Myxozoa) Fish Parasites. PMID:33003479
High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite. PMID:33001992
Papain-Like Proteases as Coronaviral Drug Targets: Current Inhibitors, Opportunities, and Limitations. PMID:32998368
Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila. PMID:32973204
Extracellular vesicles from the apoplastic fungal wheat pathogen Zymoseptoria tritici. PMID:32968488
Multiplex enzyme activity imaging by MALDI-IMS of substrate library conversions. PMID:32968143
Comparative study of protease hydrolysis reaction demonstrating Normalized Peptide Bond Cleavage Frequency and Protease Substrate Broadness Index. PMID:32956384
Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis. PMID:32952127
Neprilysin as a Biomarker: Challenges and Opportunities. PMID:32944293
Metabolic cooperativity between Porphyromonas gingivalis and Treponema denticola. PMID:32944158
Lighting Conditions Influence the Dynamics of Protease Synthesis and Proteasomal Activity in the White Rot Fungus Cerrena unicolor. PMID:32942733
Cathepsin Inhibition Modulates Metabolism and Polarization of Tumor-Associated Macrophages. PMID:32927704
Impact of Storage Conditions on the Breast Milk Peptidome. PMID:32911625
Hemolymph protease-5 links the melanization and Toll immune pathways in the tobacco hornworm, Manduca sexta. PMID:32900946
Extracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection: A Proteomics Study. PMID:32900843
High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma. PMID:32899982
Genome-wide identification of the Sec-dependent secretory protease genes in Erwinia amylovora and analysis of their expression during infection of immature pear fruit. PMID:32893528
Proteomic analysis and optimized production of Alkalihalobacillus patagoniensis PAT 05T extracellular proteases. PMID:32888092
Telomere-to-telomere assembled and centromere annotated genomes of the two main subspecies of the button mushroom Agaricus bisporus reveal especially polymorphic chromosome ends. PMID:32887908
Citrus Vascular Proteomics Highlights the Role of Peroxidases and Serine Proteases during Huanglongbing Disease Progression. PMID:32883801
Insights into the Vertical Stratification of Microbial Ecological Roles across the Deepest Seawater Column on Earth. PMID:32867361
Abundance, Diversity and Role of ICEs and IMEs in the Adaptation of Streptococcus salivarius to the Environment. PMID:32858915
Whole-Genome Sequencing and Bioinformatics Analysis of Apiotrichum mycotoxinivorans: Predicting Putative Zearalenone-Degradation Enzymes. PMID:32849454
Structural analysis of experimental drugs binding to the SARS-CoV-2 target TMPRSS2. PMID:32829149
Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival. PMID:32826880
Chromosome-scale genome assembly of sweet cherry (Prunus avium L.) cv. Tieton obtained using long-read and Hi-C sequencing. PMID:32821405
Antimicrobial Susceptibility Testing of Antimicrobial Peptides to Better Predict Efficacy. PMID:32733816
An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella. PMID:32719160
Protein-Protein Binding as a Two-Step Mechanism: Preselection of Encounter Poses during the Binding of BPTI and Trypsin. PMID:32697976
Conserved Pigment Profiles in Phylogenetically Diverse Symbiotic Bacteria Associated with the Corals Montastraea cavernosa and Mussismilia braziliensis. PMID:32681284
Biofilm and Pathogenesis-Related Proteins in the Foodborne P. fluorescens ITEM 17298 With Distinctive Phenotypes During Cold Storage. PMID:32670211
An Irreversible Inhibitor to Probe the Role of Streptococcus pyogenes Cysteine Protease SpeB in Evasion of Host Complement Defenses. PMID:32662975
Transcriptomic and Ultrastructural Signatures of K+-Induced Aggregation in Phytophthora parasitica Zoospores. PMID:32645882
Genome sequence and spore germination-associated transcriptome analysis of Corynespora cassiicola from cucumber. PMID:32641051
A proposed treatment for pathogenic enveloped viruses having high rates of mutation or replication. PMID:32640050
Comparison of protease and aminopeptidase activities in meconium: A pilot study. PMID:32607236
Novel keratinolytic enzymes, discovered from a talented and efficient bacterial keratin degrader. PMID:32572051
Pontiella desulfatans gen. nov., sp. nov., and Pontiella sulfatireligans sp. nov., Two Marine Anaerobes of the Pontiellaceae fam. nov. Producing Sulfated Glycosaminoglycan-like Exopolymers. PMID:32570748
Identification and characterization of diverse OTU deubiquitinases in bacteria. PMID:32567101
Biochemical characterization of two new Aspergillus niger aspartic proteases. PMID:32566441
Activity-based protein profiling guided identification of urine proteinase 3 activity in subclinical rejection after renal transplantation. PMID:32549867
Prolyl Oligopeptidase From Leishmania infantum: Biochemical Characterization and Involvement in Macrophage Infection. PMID:32547514
Essential roles for deubiquitination in Leishmania life cycle progression. PMID:32544189
Degradation of thymic humoral factor γ2 in human, rat and mouse blood: An experimental and theoretical study. PMID:32512181
Linking extracellular enzymes to phylogeny indicates a predominantly particle-associated lifestyle of deep-sea prokaryotes. PMID:32494615
Phage G Structure at 6.1 Å Resolution, Condensed DNA, and Host Identity Revision to a Lysinibacillus. PMID:32454153
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC. PMID:32452762
Procleave: Predicting Protease-specific Substrate Cleavage Sites by Combining Sequence and Structural Information. PMID:32413515
The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases. PMID:32385587
The tale of caspase homologues and their evolutionary outlook: deciphering programmed cell death in cyanobacteria. PMID:32369588
Molecular Properties and New Potentials of Plant Nepenthesins. PMID:32365700
Redox-Mediated Post-Translational Modifications of Proteolytic Enzymes and Their Role in Protease Functioning. PMID:32340246
Identification of Malassezia furfur Secreted Aspartyl Protease 1 (MfSAP1) and Its Role in Extracellular Matrix Degradation. PMID:32328468
Cathepsins in the Pathophysiology of Mucopolysaccharidoses: New Perspectives for Therapy. PMID:32326609
In silico Proteomic Analysis Provides Insights Into Phylogenomics and Plant Biomass Deconstruction Potentials of the Tremelalles. PMID:32318549
Comparison of metal-bound and unbound structures of aminopeptidase B proteins from Escherichia coli and Yersinia pestis. PMID:32306515
Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airways. PMID:32303635
Exploring the Potential for Fungal Antagonism and Cell Wall Attack by Bacillus subtilis natto. PMID:32296406
Dysregulation of Type II Transmembrane Serine Proteases and Ligand-Dependent Activation of MET in Urological Cancers. PMID:32290402
Analysis of the inhibiting activity of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) on matrix metalloproteinases. PMID:32286475
The Two Deubiquitinating Enzymes from Chlamydia trachomatis Have Distinct Ubiquitin Recognition Properties. PMID:32275137
Structure of the protective nematode protease complex H-gal-GP and its conservation across roundworm parasites. PMID:32271834
Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy. PMID:32265283
Evolution of new enzymes by gene duplication and divergence. PMID:32250558
Genomic Features of Cladobotryum dendroides, Which Causes Cobweb Disease in Edible Mushrooms, and Identification of Genes Related to Pathogenicity and Mycoparasitism. PMID:32245129
Differential effects of 'resurrecting' Csp pseudoproteases during Clostridioides difficile spore germination. PMID:32242623
Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling. PMID:32238573
Ste24: An Integral Membrane Protein Zinc Metalloprotease with Provocative Structure and Emergent Biology. PMID:32199981
Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants. PMID:32178437
FAM111A protects replication forks from protein obstacles via its trypsin-like domain. PMID:32165630
NBCZone: Universal three-dimensional construction of eleven amino acids near the catalytic nucleophile and base in the superfamily of (chymo)trypsin-like serine fold proteases. PMID:32151723
Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases. PMID:32142688
Tryp-N: A Thermostable Protease for the Production of N-terminal Argininyl and Lysinyl Peptides. PMID:32141294
Data mining of metagenomes to find novel enzymes: a non-computationally intensive method. PMID:32099729
A M35 family metalloprotease is required for fungal virulence against insects by inactivating host prophenoloxidases and beyond. PMID:32079481
Polysaccharide niche partitioning of distinct Polaribacter clades during North Sea spring algal blooms. PMID:32071394
Metabolic potentials of archaeal lineages resolved from metagenomes of deep Costa Rica sediments. PMID:32066876
Genomic insights into the lifestyles, functional capacities and oleagenicity of members of the fungal family Trichosporonaceae. PMID:32066798
Comprehensive Proteomic Characterization Reveals Subclass-Specific Molecular Aberrations within Triple-negative Breast Cancer. PMID:32058975
Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion. PMID:31998844
Diversity and metabolism of Woeseiales bacteria, global members of marine sediment communities. PMID:31988474
An M29 Aminopeptidase from Listeria Monocytogenes Contributes to In Vitro Bacterial Growth but not to Intracellular Infection. PMID:31941013
Biochemical characterization of Ty1 retrotransposon protease. PMID:31917798
Partial Characterization of Two Cathepsin D Family Aspartic Peptidases of Clonorchis sinensis. PMID:31914521
Peptidomic Analysis of Urine from Youths with Early Type 1 Diabetes Reveals Novel Bioactivity of Uromodulin Peptides In Vitro. PMID:31879271
Genome-Wide Identification and Expression Analysis of the Protease Inhibitor Gene Families in Tomato. PMID:31861342
A diverse uncultivated microbial community is responsible for organic matter degradation in the Black Sea sulphidic zone. PMID:31858660
Identification and characterization of Schizophyllum commune type I metacaspases. PMID:31844687
Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase. PMID:31826021
BIOPEP-UWM Database of Bioactive Peptides: Current Opportunities. PMID:31783634
Engineering the serpin α1 -antitrypsin: A diversity of goals and techniques. PMID:31774589
Peptides Derived of Kunitz-Type Serine Protease Inhibitor as Potential Vaccine Against Experimental Schistosomiasis. PMID:31736947
Structure-Function Relationships of the Repeat Domains of RTX Toxins. PMID:31718085
Characterisation of early metazoan secretion through associated signal peptidase complex subunits, prohormone convertases and carboxypeptidases of the marine sponge (Amphimedon queenslandica). PMID:31714927
Genomic and phenotypic insights point to diverse ecological strategies by facultative anaerobes obtained from subsurface coal seams. PMID:31700097
RareLSD: a manually curated database of lysosomal enzymes associated with rare diseases. PMID:31688938
'One DB to rule them all'-the RING: a Regulatory INteraction Graph combining TFs, genes/proteins, SNPs, diseases and drugs. PMID:31682269
Comparative Genome Analyses Reveal the Genomic Traits and Host Plant Adaptations of Flavobacterium akiainvivens IK-1T. PMID:31623351
Dealing With Stress: A Review of Plant SUMO Proteases. PMID:31620153
Challenges in the annotation of pseudoenzymes in databases: the UniProtKB approach. PMID:31618524
Bioinformatics for Marine Products: An Overview of Resources, Bottlenecks, and Perspectives. PMID:31614509
Identification of keratinases from Fervidobacterium islandicum AW-1 using dynamic gene expression profiling. PMID:31613061
How metal cofactors drive dimer-dodecamer transition of the M42 aminopeptidase TmPep1050 of Thermotoga maritima. PMID:31611236
The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases. PMID:31604990
Variable Surface Glycoprotein from Trypanosoma brucei Undergoes Cleavage by Matrix Metalloproteinases: An in silico Approach. PMID:31597256
Glucose-Mediated Repression of Plant Biomass Utilization in the White-Rot Fungus Dichomitus squalens. PMID:31585998
A homology-guided, genome-based proteome for improved proteomics in the alloploid Nicotiana benthamiana. PMID:31585525
Ruminococcin C, a promising antibiotic produced by a human gut symbiont. PMID:31579822
The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology. PMID:31577948
DeepCleave: a deep learning predictor for caspase and matrix metalloprotease substrates and cleavage sites. PMID:31566664
Top-Down Proteomic Characterization of Truncated Proteoforms. PMID:31545043
Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles. PMID:31544965
Genome Sequence of Metarhizium rileyi, a Microbial Control Agent for Lepidoptera. PMID:31488537
Molecular evidence for origin, diversification and ancient gene duplication of plant subtilases (SBTs). PMID:31462749
Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex. PMID:31455655
Niche differentiation among annually recurrent coastal Marine Group II Euryarchaeota. PMID:31447484
A two-component protease in Methylorubrum extorquens with high activity toward the peptide precursor of the redox cofactor pyrroloquinoline quinone. PMID:31427437
Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells. PMID:31413794
Barley cysteine protease PAP14 plays a role in degradation of chloroplast proteins. PMID:31403664
Metacaspases: Potential Drug Target Against Protozoan Parasites. PMID:31379569
Origins of peptidases. PMID:31377195
Molecular characterization and functional analysis of the Schistosoma mekongi Ca2+-dependent cysteine protease (calpain). PMID:31362766
Identification and characterization of RSIY-11, a novel seminal peptide derived from semenogelin-1, which acts as a neutral endopeptidase inhibitor modulating sperm motility. PMID:31346917
Functional and Pharmacological Analyses of the Role of Penicillium digitatum Proteases on Virulence. PMID:31336863
Predictive models of protease specificity based on quantitative protease-activity profiling data. PMID:31330204
Kinetics and Identities of Extracellular Peptidases in Subsurface Sediments of the White Oak River Estuary, North Carolina. PMID:31324636
Genome-Wide and Functional View of Proteolytic and Lipolytic Bacteria for Efficient Biogas Production through Enhanced Sewage Sludge Hydrolysis. PMID:31323902
Ubiquinone Biosynthesis over the Entire O2 Range: Characterization of a Conserved O2-Independent Pathway. PMID:31289180
Selective Proteolysis of α-Lactalbumin by Endogenous Enzymes of Human Milk at Acidic pH. PMID:31271254
Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity. PMID:31230350
Plant proteases and programmed cell death. PMID:31222306
Peptide-based protease inhibitors from plants. PMID:31170506
Comparative genome analysis indicates high evolutionary potential of pathogenicity genes in Colletotrichum tanaceti. PMID:31150449
Genome Analysis of Hypomyces perniciosus, the Causal Agent of Wet Bubble Disease of Button Mushroom (Agaricus bisporus). PMID:31146507
Analysing Point Mutations in Protein Cleavage Sites by Using Enzyme Specificity Matrices. PMID:31130917
β-Aminopeptidases: Insight into Enzymes without a Known Natural Substrate. PMID:31126950
Proteases Underground: Analysis of the Maize Root Apoplast Identifies Organ Specific Papain-Like Cysteine Protease Activity. PMID:31114592
Hybrid Assembly of the Genome of the Entomopathogenic Nematode Steinernema carpocapsae Identifies the X-Chromosome. PMID:31113823
Functional characterization of a subtilisin-like serine protease from Vibrio cholerae. PMID:31076508
Metabolic potential of uncultured bacteria and archaea associated with petroleum seepage in deep-sea sediments. PMID:31000700
The Role and Regulation of Autophagy and the Proteasome During Aging and Senescence in Plants. PMID:30987024
The EMBL-EBI search and sequence analysis tools APIs in 2019. PMID:30976793
Draft Genome Sequence of Lactobacillus plantarum CRL681, Isolated from Argentinean Artisanal Fermented Sausages. PMID:30975815
A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif. PMID:30952847
Adaptations of Alteromonas sp. 76-1 to Polysaccharide Degradation: A CAZyme Plasmid for Ulvan Degradation and Two Alginolytic Systems. PMID:30936857
Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS. PMID:30923071
High-Level Expression in Escherichia coli, Purification and Kinetic Characterization of LAPTc, a Trypanosoma cruzi M17-Aminopeptidase. PMID:30905022
Protease Activity Profiling of Snake Venoms Using High-Throughput Peptide Screening. PMID:30893860
Distributions of Extracellular Peptidases Across Prokaryotic Genomes Reflect Phylogeny and Habitat. PMID:30891022
Plant Serine Protease Inhibitors: Biotechnology Application in Agriculture and Molecular Farming. PMID:30884891
Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate. PMID:30858219
High Genetic Potential for Proteolytic Decomposition in Northern Peatland Ecosystems. PMID:30850433
SERPINs-From Trap to Treatment. PMID:30809526
Endopeptidase Regulation as a Novel Function of the Zur-Dependent Zinc Starvation Response. PMID:30782657
A Novel Analysis of the Peptide Terminome Characterizes Dynamics of Proteolytic Regulation in Vertebrate Skeletal Muscle Under Severe Stress. PMID:30781840
A Recurrent Motif: Diversity and Evolution of ShKT Domain Containing Proteins in the Vampire Snail Cumia reticulata. PMID:30759797
Genome Sequencing of Cladobotryum protrusum Provides Insights into the Evolution and Pathogenic Mechanisms of the Cobweb Disease Pathogen on Cultivated Mushroom. PMID:30744046
Development of a novel, high-affinity ssDNA trypsin inhibitor. PMID:30727784
The Role of Proteases in the Virulence of Plant Pathogenic Bacteria. PMID:30720762
Proteases: History, discovery, and roles in health and disease. PMID:30710012
Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion. PMID:30705155
Curcumin inhibits the TGF-β1-dependent differentiation of lung fibroblasts via PPARγ-driven upregulation of cathepsins B and L. PMID:30679571
Do proteolytic cascades exist in plants? PMID:30668744
Expanding Repertoire of Plant Positive-Strand RNA Virus Proteases. PMID:30650571
Comparative genomics of Botryosphaeria dothidea and B. kuwatsukai, causal agents of apple ring rot, reveals both species expansion of pathogenicity-related genes and variations in virulence gene content during speciation. PMID:30622881
Strawberry Mottle Virus (Family Secoviridae, Order Picornavirales) Encodes a Novel Glutamic Protease To Process the RNA2 Polyprotein at Two Cleavage Sites. PMID:30541838
Intracellular metalloprotease activity controls intraneuronal Aβ aggregation and limits secretion of Aβ via exosomes. PMID:30481490
PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools. PMID:30407594
The structure of PghL hydrolase bound to its substrate poly-γ-glutamate. PMID:30387270
The Pfam protein families database in 2019. PMID:30357350
An insight into gut microbiota and its functionalities. PMID:30317530
Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases. PMID:30314342
Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods. PMID:30184176
Revised nomenclature and functional overview of the ULP gene family of plant deSUMOylating proteases. PMID:30124991
New Insights into the Occurrence of Matrix Metalloproteases -2 and -9 in a Cohort of Breast Cancer Patients and Proteomic Correlations. PMID:30060564
Arabidopsis Kunitz Trypsin Inhibitors in Defense Against Spider Mites. PMID:30042779
HMMER web server: 2018 update. PMID:29905871
Production and Characterization of an Extracellular Acid Protease from Thermophilic Brevibacillus sp. OA30 Isolated from an Algerian Hot Spring. PMID:29649122
The 2018 Nucleic Acids Research database issue and the online molecular biology database collection. PMID:29316735
The European Bioinformatics Institute in 2017: data coordination and integration. PMID:29186510
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors PubMed citations: 384.

384 articles citing: MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

Genome-Wide Analysis of the Peptidase M24 Superfamily in Triticum aestivum Demonstrates That TaM24-9 Is Involved in Abiotic Stress Response. PMID:35805912
Genome-wide comparison deciphers lifestyle adaptation and glass biodeterioration property of Curvularia eragrostidis C52. PMID:35794131
Peptidomic changes in the milk of water buffaloes (Bubalus bubalis) with intramammary infection by non-aureus staphylococci. PMID:35589845
Does DPP-IV Inhibition Offer New Avenues for Therapeutic Intervention in Malignant Disease? PMID:35565202
Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors. PMID:35494659
Exploiting protease activation for therapy. PMID:35314338
Carbohydrate active enzymes (CAZy) regulate cellulolytic and pectinolytic enzymes in Colletotrichum falcatum causing red rot in sugarcane. PMID:35127303
Proteomics of Two Thermotolerant Isolates of Trichoderma under High-Temperature Stress. PMID:34946985
Potential of Thermolysin-like Protease A69 in Preparation of Bovine Collagen Peptides with Moisture-Retention Ability and Antioxidative Activity. PMID:34940675
Aspergillus fumigatus pan-genome analysis identifies genetic variants associated with human infection. PMID:34819642
"The PLCP gene family of grapevine (Vitis vinifera L.): characterization and differential expression in response to Plasmopara Viticola". PMID:34717550
Identical sequences found in distant genomes reveal frequent horizontal transfer across the bacterial domain. PMID:34121661
Sphingomonas sp. KT-1 PahZ2 Structure Reveals a Role for Conformational Dynamics in Peptide Bond Hydrolysis. PMID:34060838
Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation. PMID:33948354
Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V. PMID:33786919
Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes. PMID:33745969
Biochemical characterisation of a collagenase from Bacillus cereus strain Q1. PMID:33603127
Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease. PMID:33409475
Competitive Exclusion and Metabolic Dependency among Microorganisms Structure the Cellulose Economy of an Agricultural Soil. PMID:33402535
Neuroinflammation-Induced Upregulation of Glial Cathepsin X Expression and Activity in vivo. PMID:33328882
Cathepsin B is highly expressed in pancreatic cancer stem-like cells and is associated with patients' surgical outcomes. PMID:33240436
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PMID:33141865
Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries. PMID:32973096
Metabolic cooperativity between Porphyromonas gingivalis and Treponema denticola. PMID:32944158
The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease. PMID:32793222
The Procoagulant Snake Venom Serine Protease Potentially Having a Dual, Blood Coagulation Factor V and X-Activating Activity. PMID:32485989
Modelling of pH-dependence to develop a strategy for stabilising mAbs at acidic steps in production. PMID:32322371
Dysregulated activities of proline-specific enzymes in septic shock patients (sepsis-2). PMID:32315321
Data on the genome analysis of the wood-rotting fungus Steccherinum ochraceum LE-BIN 3174. PMID:32055659
Time-resolved proteomic profile of Amblyomma americanum tick saliva during feeding. PMID:32049966
The Subtilisin-Like Protease Bcser2 Affects the Sclerotial Formation, Conidiation and Virulence of Botrytis cinerea. PMID:31963451
Cathepsin S as a target in gastric cancer. PMID:31929878
Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer. PMID:31897127
The Biochemical and Functional Characterization of M28 Aminopeptidase Protein Secreted by Acanthamoeba spp. on Host Cell Interaction. PMID:31847255
Characterization of aminopeptidase encoding gene anp-1 and its association with development in Caenorhabditis elegans. PMID:31737443
Fungal Adaptation to the Advanced Stages of Wood Decomposition: Insights from the Steccherinum ochraceum. PMID:31694151
Purification, characterization, and structural elucidation of serralysin-like alkaline metalloprotease from a novel source. PMID:31659553
Identification of keratinases from Fervidobacterium islandicum AW-1 using dynamic gene expression profiling. PMID:31613061
Deciphering Design Principles of Förster Resonance Energy Transfer-Based Protease Substrates: Thermolysin-Like Protease from Geobacillus stearothermophilus as a Test Case. PMID:31458650
A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases. PMID:31391482
Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution. PMID:31324776
RedoxiBase: A database for ROS homeostasis regulated proteins. PMID:31228650
Repertoire of the Bacillus thuringiensis Virulence Factors Unrelated to Major Classes of Protein Toxins and Its Role in Specificity of Host-Pathogen Interactions. PMID:31212976
Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus. PMID:31078932
Reactive Oxygen Species-Mediated Cezanne Inactivation by Oxidation of its Catalytic Cysteine Residue in Hepatocellular Carcinoma. PMID:31072419
Identification and characterization of a secreted M28 aminopeptidase protein in Acanthamoeba. PMID:31065830
Infection mechanisms and putative effector repertoire of the mosquito pathogenic oomycete Pythium guiyangense uncovered by genomic analysis. PMID:31017897
Genomic Characterization of Candidate Division LCP-89 Reveals an Atypical Cell Wall Structure, Microcompartment Production, and Dual Respiratory and Fermentative Capacities. PMID:30902854
A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of Streptomyces clavuligerus ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications. PMID:30891203
Nontherapeutic equivalence of a generic product of imipenem-cilastatin is caused more by chemical instability of the active pharmaceutical ingredient (imipenem) than by its substandard amount of cilastatin. PMID:30726248
Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif. PMID:30668585
Mass Spectrometry-Based Comprehensive Analysis of Pancreatic Cyst Fluids. PMID:30627566
Uncovering the Structural Basis of a New Twist in Protein Ubiquitination. PMID:30583962
Microbial Keratinases: Enzymes with Promising Biotechnological Applications. PMID:30510475
Upregulation of Cysteine Protease Cathepsin X in the 6-Hydroxydopamine Model of Parkinson's Disease. PMID:30450037
Carboxypeptidase O is a lipid droplet-associated enzyme able to cleave both acidic and polar C-terminal amino acids. PMID:30388170
Isolation and Characterization of Poecistasin, an Anti-Thrombotic Antistasin-Type Serine Protease Inhibitor from Leech Poecilobdella manillensis. PMID:30373118
Comparative Genomics of Aspergillus flavus S and L Morphotypes Yield Insights into Niche Adaptation. PMID:30361280
De novo genome and transcriptome analyses provide insights into the biology of the trematode human parasite Fasciolopsis buski. PMID:30325945
Insight into the draft whole-genome sequence of the dermatophyte Arthroderma vanbreuseghemii. PMID:30310114
The contribution of Tannerella forsythia dipeptidyl aminopeptidase IV in the breakdown of collagen. PMID:30171738
Molecular Cloning and Docking of speB Gene Encoding Cysteine Protease With Antibiotic Interaction in Streptococcus pyogenes NBMKU12 From the Clinical Isolates. PMID:30131773
Polysaccharide utilization loci of North Sea Flavobacteriia as basis for using SusC/D-protein expression for predicting major phytoplankton glycans. PMID:30111868
Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin. PMID:30013126
Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states. PMID:29967063
Comprehensive analysis of Verticillium nonalfalfae in silico secretome uncovers putative effector proteins expressed during hop invasion. PMID:29894496
Characterization of a Glycyl-Specific TET Aminopeptidase Complex from Pyrococcus horikoshii. PMID:29866801
Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. PMID:29808012
Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family. PMID:29794027
From plants to nematodes: Serratia grimesii BXF1 genome reveals an adaptation to the modulation of multi-species interactions. PMID:29781797
Comparative Genomics of Smut Pathogens: Insights From Orphans and Positively Selected Genes Into Host Specialization. PMID:29681893
Molecular pathways for antigenic peptide generation by ER aminopeptidase 1. PMID:29678301
miR-148b Functions as a Tumor Suppressor by Targeting Endoplasmic Reticulum Metallo Protease 1 in Human Endometrial Cancer Cells. PMID:29523216
Milk Proteins Are Predigested Within the Human Mammary Gland. PMID:29464498
Genome mining for peptidases in heat-tolerant and mesophilic fungi and putative adaptations for thermostability. PMID:29463214
Draft genome sequence of Xylaria sp., the causal agent of taproot decline of soybean in the southern United States. PMID:29349107
Tissue-specific transcriptomes of Anisakis simplex (sensu stricto) and Anisakis pegreffii reveal potential molecular mechanisms involved in pathogenicity. PMID:29321072
De novo assembling and primary analysis of genome and transcriptome of gray whale Eschrichtius robustus. PMID:29297306
Computational predictions of cysteine cathepsin-mediated fibrinogen proteolysis. PMID:29266558
High-quality draft genome sequence of Aquidulcibacter paucihalophilus TH1-2T isolated from cyanobacterial aggregates in a eutrophic lake. PMID:29213356
An unexpected switch in peptide binding mode: from simulation to substrate specificity. PMID:29210603
To Be or Not To Be T4: Evidence of a Complex Evolutionary Pathway of Head Structure and Assembly in Giant Salmonella Virus SPN3US. PMID:29187846
Evidence for multiple modes of neutrophil serine protease recognition by the EAP family of Staphylococcal innate immune evasion proteins. PMID:29114958
Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library. PMID:29057062
Protease activity of legumain is inhibited by an increase of cystatin E/M in the DJ-1-knockout mouse spleen, cerebrum and heart. PMID:28956004
Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella. PMID:28900095
Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiology. PMID:28861360
Alternaria Toxins: Potential Virulence Factors and Genes Related to Pathogenesis. PMID:28848500
Genome sequencing and comparative genomics reveal a repertoire of putative pathogenicity genes in chilli anthracnose fungus Colletotrichum truncatum. PMID:28846714
The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases. PMID:28824657
Comparative sequence analysis reveals regulation of genes in developing schistosomula of Schistosoma mansoni exposed to host portal serum. PMID:28622369
Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer. PMID:28585723
The expression of proline-specific enzymes in the human lung. PMID:28462210
Mechanistic study of CBT-Cys click reaction and its application for identifying bioactive N-terminal cysteine peptides in amniotic fluid. PMID:28451168
Genome characteristics of the proteorhodopsin-containing marine flavobacterium Polaribacter dokdonensis DSW-5. PMID:28432541
Activated entomopathogenic nematode infective juveniles release lethal venom proteins. PMID:28426766
Genomics insights into different cellobiose hydrolysis activities in two Trichoderma hamatum strains. PMID:28420406
Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner. PMID:28388673
Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein Interactions. PMID:28385878
A repertoire of protease inhibitor families in Amblyomma americanum and other tick species: inter-species comparative analyses. PMID:28330502
Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis. PMID:28167503
Genomic insight into pathogenicity of dematiaceous fungus Corynespora cassiicola. PMID:28149676
PERM Hypothesis: The Fundamental Machinery Able to Elucidate the Role of Xenobiotics and Hormesis in Cell Survival and Homeostasis. PMID:28098843
Interactome disassembly during apoptosis occurs independent of caspase cleavage. PMID:28082348
M1 aminopeptidases as drug targets: broad applications or therapeutic niche? PMID:28075056
Functional and structural characterization of a novel putative cysteine protease cell wall-modifying multi-domain enzyme selected from a microbial metagenome. PMID:27934875
A Strong Neutrophil Elastase Proteolytic Fingerprint Marks the Carcinoma Tumor Proteome. PMID:27927741
Effects of Glycosylation on the Enzymatic Activity and Mechanisms of Proteases. PMID:27898009
The genome, transcriptome, and proteome of the nematode Steinernema carpocapsae: evolutionary signatures of a pathogenic lifestyle. PMID:27876851
A Monoclonal Antibody to Cryptococcus neoformans Glucuronoxylomannan Manifests Hydrolytic Activity for Both Peptides and Polysaccharides. PMID:27872188
Extracellular Bacterial Proteases in Chronic Wounds: A Potential Therapeutic Target? PMID:27785379
A Bowman-Birk protease inhibitor purified, cloned, sequenced and characterized from the seeds of Maclura pomifera (Raf.) Schneid. PMID:27778107
mdRNA-Seq analysis of marine microbial communities from the northern Red Sea. PMID:27759035
Genome Anatomy of Pyrenochaeta unguis-hominis UM 256, a Multidrug Resistant Strain Isolated from Skin Scraping. PMID:27626635
Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10. PMID:27611765
A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma. PMID:27573075
Genomic Analyses of Cladophialophora bantiana, a Major Cause of Cerebral Phaeohyphomycosis Provides Insight into Its Lifestyle, Virulence and Adaption in Host. PMID:27570972
ERMP1, a novel potential oncogene involved in UPR and oxidative stress defense, is highly expressed in human cancer. PMID:27566589
Gene family expansions and contractions are associated with host range in plant pathogens of the genus Colletotrichum. PMID:27496087
Germinants and Their Receptors in Clostridia. PMID:27432831
Draft Whole-Genome Sequence of the Type Strain Bacillus aquimaris TF12T. PMID:27417832
Biosynthesis of Antibiotic Leucinostatins in Bio-control Fungus Purpureocillium lilacinum and Their Inhibition on Phytophthora Revealed by Genome Mining. PMID:27416025
Activation Mechanism of the Bacteroides fragilis Cysteine Peptidase, Fragipain. PMID:27379832
A comprehensive view of the web-resources related to sericulture. PMID:27307138
The Proteasix Ontology. PMID:27259807
Insights into the Cyanobacterial Deg/HtrA Proteases. PMID:27252714
Genus-Wide Comparative Genome Analyses of Colletotrichum Species Reveal Specific Gene Family Losses and Gains during Adaptation to Specific Infection Lifestyles. PMID:27189990
Fold conservation and proteolysis in zebrafish IRBP structure: Clues to possible enzymatic function? PMID:27155144
A bioavailable cathepsin S nitrile inhibitor abrogates tumor development. PMID:27097645
Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice. PMID:27089515
Microbial inhibitors of cysteine proteases. PMID:27048482
Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition. PMID:27025154
MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction. PMID:27016603
Tackling Unwanted Proteolysis in Plant Production Hosts Used for Molecular Farming. PMID:27014293
DemaDb: an integrated dematiaceous fungal genomes database. PMID:26980516
Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome. PMID:26940874
A transcriptomic insight into the infective juvenile stage of the insect parasitic nematode, Heterorhabditis indica. PMID:26931371
The role of aggrecan in normal and osteoarthritic cartilage. PMID:26914753
An Unusual Member of the Papain Superfamily: Mapping the Catalytic Cleft of the Marasmius oreades agglutinin (MOA) with a Caspase Inhibitor. PMID:26901797
The genome of newly classified Ochroconis mirabilis: Insights into fungal adaptation to different living conditions. PMID:26842951
Genomic and exoproteomic analyses of cold- and alkaline-adapted bacteria reveal an abundance of secreted subtilisin-like proteases. PMID:26834075
Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes. PMID:26783378
Ixodes scapularis Tick Saliva Proteins Sequentially Secreted Every 24 h during Blood Feeding. PMID:26751078
Site-targeted mutagenesis for stabilization of recombinant monoclonal antibody expressed in tobacco (Nicotiana tabacum) plants. PMID:26712217
Quantitative Correlation of Conformational Binding Enthalpy with Substrate Specificity of Serine Proteases. PMID:26709959
Innate Immune Response in Brain, NF-Kappa B Signaling and Cystatins. PMID:26696821
Genomic analysis of Luteimonas abyssi XH031(T): insights into its adaption to the subseafloor environment of South Pacific Gyre and ecological role in biogeochemical cycle. PMID:26690083
Targeting Cathepsin B for Cancer Therapies. PMID:26623174
Aminopeptidase T of M29 Family Acts as A Novel Intracellular Virulence Factor for Listeria monocytogenes Infection. PMID:26610705
Genome analysis of Daldinia eschscholtzii strains UM 1400 and UM 1020, wood-decaying fungi isolated from human hosts. PMID:26581579
Ectomycorrhizal fungi decompose soil organic matter using oxidative mechanisms adapted from saprotrophic ancestors. PMID:26527297
Captured metagenomics: large-scale targeting of genes based on 'sequence capture' reveals functional diversity in soils. PMID:26490729
Draft genome sequence of the intestinal parasite Blastocystis subtype 4-isolate WR1. PMID:26484170
Sequence and structure-based comparative analysis to assess, identify and improve the thermostability of penicillin G acylases. PMID:26419382
Comparative genomics of Steinernema reveals deeply conserved gene regulatory networks. PMID:26392177
A secretory leukocyte protease inhibitor variant with improved activity against lung infection. PMID:26376365
Polar Desolvation and Position 226 of Pancreatic and Neutrophil Elastases Are Crucial to their Affinity for the Kunitz-Type Inhibitors ShPI-1 and ShPI-1/K13L. PMID:26372354
Structure of zebrafish IRBP reveals fatty acid binding. PMID:26344741
Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs. PMID:26216096
ADAMTS7 locus confers high cross-race risk for development of coronary atheromatous plaque. PMID:26189211
Functional expression, purification, and biochemical properties of subtilase SprP from Pseudomonas aeruginosa. PMID:26175208
Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates. PMID:26175157
A novel truncated form of apolipoprotein A-I transported by dense LDL is increased in diabetic patients. PMID:26168996
Discovery of new protein families and functions: new challenges in functional metagenomics for biotechnologies and microbial ecology. PMID:26097471
Handicap-Recover Evolution Leads to a Chemically Versatile, Nucleophile-Permissive Protease. PMID:26097079
Trichomonas vaginalis Cysteine Proteinases: Iron Response in Gene Expression and Proteolytic Activity. PMID:26090464
Structural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity. PMID:26057589
Cracking the nodule worm code advances knowledge of parasite biology and biotechnology to tackle major diseases of livestock. PMID:26026709
Genome Anatomy of Streptococcus parasanguinis Strain C1A, Isolated from a Patient with Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Reveals Unusual Genomic Features. PMID:26021924
The path of no return--Truncated protein N-termini and current ignorance of their genesis. PMID:26010509
Matrix metalloproteinases as breast cancer drivers and therapeutic targets. PMID:25961550
Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site. PMID:25905034
Characterization of a vacuolar processing enzyme expressed in Arachis diogoi in resistance responses against late leaf spot pathogen, Phaeoisariopsis personata. PMID:25893777
The Alternaria genomes database: a comprehensive resource for a fungal genus comprised of saprophytes, plant pathogens, and allergenic species. PMID:25887485
MetCap: a bioinformatics probe design pipeline for large-scale targeted metagenomics. PMID:25880302
Inhibition of outer membrane proteases of the omptin family by aprotinin. PMID:25824836
MALDI-TOF MS and CD spectral analysis for identification and structure prediction of a purified, novel, organic solvent stable, fibrinolytic metalloprotease from Bacillus cereus B80. PMID:25802851
GRYFUN: a web application for GO term annotation visualization and analysis in protein sets. PMID:25794277
Isolation and identification of an extracellular subtilisin-like serine protease secreted by the bat pathogen Pseudogymnoascus destructans. PMID:25785714
The carbon starvation response of the ectomycorrhizal fungus Paxillus involutus. PMID:25778509
Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18. PMID:25700165
Comparative structural analysis of the caspase family with other clan CD cysteine peptidases. PMID:25697094
Crystallization and preliminary X-ray crystallographic studies of dipeptidyl peptidase 11 from Porphyromonas gingivalis. PMID:25664797
Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters. PMID:25600171
Cysteine cathepsin activity regulation by glycosaminoglycans. PMID:25587532
Structural insight into effector proteins of Gram-negative bacterial pathogens that modulate the phosphoproteome of their host. PMID:25565677
A metalloprotease secreted by the type II secretion system links Vibrio cholerae with collagen. PMID:25561716
Identification of horizontally transferred genes in the genus Colletotrichum reveals a steady tempo of bacterial to fungal gene transfer. PMID:25555398
Functional annotation of the Ophiostoma novo-ulmi genome: insights into the phytopathogenicity of the fungal agent of Dutch elm disease. PMID:25539722
Investigation of protein secretion and secretion stress in Ashbya gossypii. PMID:25523110
Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells. PMID:25520721
In vivo assessment of protease dynamics in cutaneous wound healing by degradomics analysis of porcine wound exudates. PMID:25516628
Helical shape of Helicobacter pylori requires an atypical glutamine as a zinc ligand in the carboxypeptidase Csd4. PMID:25505267
gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. PMID:25420147
Comparative transcriptomics reveals striking similarities between the bovine and feline isolates of Tritrichomonas foetus: consequences for in silico drug-target identification. PMID:25374366
Structural phylogeny by profile extraction and multiple superimposition using electrostatic congruence as a discriminator. PMID:25364645
Expression analysis of all protease genes reveals cathepsin K to be overexpressed in glioblastoma. PMID:25356585
Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue. PMID:25329061
Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin. PMID:25301953
Expression profile of the Schistosoma japonicum degradome reveals differential protease expression patterns and potential anti-schistosomal intervention targets. PMID:25275570
Comparative genomics of planktonic Flavobacteriaceae from the Gulf of Maine using metagenomic data. PMID:25258679
Modeling of human M1 aminopeptidases for in silico screening of potential Plasmodium falciparum alanine aminopeptidase (PfA-M1) specific inhibitors. PMID:25258488
Lymph is not a plasma ultrafiltrate: a proteomic analysis of injured patients. PMID:25243428
Bioinformatic analyses of male and female Amblyomma americanum tick expressed serine protease inhibitors (serpins). PMID:25238688
Proteolytic activity of prostate-specific antigen (PSA) towards protein substrates and effect of peptides stimulating PSA activity. PMID:25237904
Structure and function of REP34 implicates carboxypeptidase activity in Francisella tularensis host cell invasion. PMID:25231992
Current functional metagenomic approaches only expand the existing protease sequence space, but does not presently add any novelty to it. PMID:25141963
PlantCAZyme: a database for plant carbohydrate-active enzymes. PMID:25125445
Engineering neprilysin activity and specificity to create a novel therapeutic for Alzheimer's disease. PMID:25089527
Genomes and transcriptomes of partners in plant-fungal-interactions between canola (Brassica napus) and two Leptosphaeria species. PMID:25068644
Screening of a Leptospira biflexa mutant library to identify genes involved in ethidium bromide tolerance. PMID:25063661
Comparative genomics suggests that the human pathogenic fungus Pneumocystis jirovecii acquired obligate biotrophy through gene loss. PMID:25062922
The HtrA-like protease CD3284 modulates virulence of Clostridium difficile. PMID:25047848
Tailor made plasmin substrates as potential diagnostic tool to test for mastitis. PMID:24997569
ScreenCap3: Improving prediction of caspase-3 cleavage sites using experimentally verified noncleavage sites. PMID:24995852
Genome sequencing of four Aureobasidium pullulans varieties: biotechnological potential, stress tolerance, and description of new species. PMID:24984952
Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth. PMID:24977961
Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini. PMID:24974296
Research applications of proteolytic enzymes in molecular biology. PMID:24970197
Exploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT. PMID:24933323
The crude skin secretion of the pepper frog Leptodactylus labyrinthicus is rich in metallo and serine peptidases. PMID:24906116
Genome-wide analysis of regulatory proteases sequences identified through bioinformatics data mining in Taenia solium. PMID:24899069
Extensive expansion of A1 family aspartic proteinases in fungi revealed by evolutionary analyses of 107 complete eukaryotic proteomes. PMID:24869856
Network analyses reveal pervasive functional regulation between proteases in the human protease web. PMID:24865846
The proteolytic landscape of the yeast vacuole. PMID:24843828
Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2. PMID:24830429
S46 peptidases are the first exopeptidases to be members of clan PA. PMID:24827749
Structure of the Arabidopsis thaliana TOP2 oligopeptidase. PMID:24817709
Regulation of TGF-β1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C. PMID:24790080
The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin. PMID:24785947
Proteomic analysis of cattle tick Rhipicephalus (Boophilus) microplus saliva: a comparison between partially and fully engorged females. PMID:24762651
Draft Genome Sequence of Ochroconis constricta UM 578, Isolated from Human Skin Scraping. PMID:24744321
Measurement of protein kinase B activity in single primary human pancreatic cancer cells. PMID:24716819
Structural basis for the evolution of vancomycin resistance D,D-peptidases. PMID:24711382
Interactions outside the proteinase-binding loop contribute significantly to the inhibition of activated coagulation factor XII by its canonical inhibitor from corn. PMID:24706752
Identification of predominant genes involved in regulation and execution of senescence-associated nitrogen remobilization in flag leaves of field grown barley. PMID:24700620
Identification and characterization of an asparaginyl endopeptidase from Angiostrongylus cantonensis. PMID:24696276
Characterization of the transcriptome and temperature-induced differential gene expression in QPX, the thraustochytrid parasite of hard clams. PMID:24678810
Cathepsin B: multiple roles in cancer. PMID:24677670
Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. PMID:24676141
GeneSense: a new approach for human gene annotation integrated with protein-protein interaction networks. PMID:24667292
Collaboration within the M1 aminopeptidase family promotes reproductive success in Caenorhabditis elegans. PMID:24663498
Antibacterial enzymes from the functional screening of metagenomic libraries hosted in Ralstonia metallidurans. PMID:24661178
Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis. PMID:24646163
Crystallization and preliminary X-ray crystallographic studies of dipeptidyl aminopeptidase BII from Pseudoxanthomonas mexicana WO24. PMID:24637761
N-terminal proteomics and ribosome profiling provide a comprehensive view of the alternative translation initiation landscape in mice and men. PMID:24623590
A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins. PMID:24623589
Thrombin inhibitory activity of some polyphenolic compounds. PMID:24610996
The hypervariable amino-terminus of P1 protease modulates potyviral replication and host defense responses. PMID:24603811
The AtCathB3 gene, encoding a cathepsin B-like protease, is expressed during germination of Arabidopsis thaliana and transcriptionally repressed by the basic leucine zipper protein GBF1. PMID:24600022
Proteolytic activation of human cathepsin A. PMID:24599961
Identification of the catalytic triad of family S46 exopeptidases, closely related to clan PA endopeptidases. PMID:24598890
Architecture and function of metallopeptidase catalytic domains. PMID:24596965
Aminopeptidase activities as prospective urinary biomarkers for bladder cancer. PMID:24591208
Functional properties of a cysteine proteinase from pineapple fruit with improved resistance to fungal pathogens in Arabidopsis thaliana. PMID:24566309
The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus. PMID:24562348
A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. PMID:24553140
Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling. PMID:24550277
Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics. PMID:24550258
Bacterial proteases: targets for diagnostics and therapy. PMID:24535571
Structural and enzymatic characterization of a host-specificity determinant from Salmonella. PMID:24531472
High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies. PMID:24531462
Functional analysis of a subtilisin-like serine protease gene from biocontrol fungus Trichoderma harzianum. PMID:24500477
Structure to function prediction of hypothetical protein KPN_00953 (Ycbk) from Klebsiella pneumoniae MGH 78578 highlights possible role in cell wall metabolism. PMID:24499172
Comparative genomics provide insights into evolution of trichoderma nutrition style. PMID:24482532
The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification. PMID:24464998
Functional and structural characterization of Vibrio cholerae extracellular serine protease B, VesB. PMID:24459146
LmaPA2G4, a homolog of human Ebp1, is an essential gene and inhibits cell proliferation in L. major. PMID:24421916
Leucoagaricus gongylophorus uses leaf-cutting ants to vector proteolytic enzymes towards new plant substrate. PMID:24401858
Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. PMID:24395329
Subtilase SprP exerts pleiotropic effects in Pseudomonas aeruginosa. PMID:24376018
Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus. PMID:24375505
Substrate sequences tell similar stories as binding cavities: commentary. PMID:24359119
Regulated proteolysis in bacterial development. PMID:24354618
Cathepsin B/X is secreted by Echinometra lucunter sea urchin spines, a structure rich in granular cells and toxins. PMID:24341625
Evolution of the thermopsin peptidase family (A5). PMID:24312173
Characterization of the Pseudomonas aeruginosa metalloendopeptidase, Mep72, a member of the Vfr regulon. PMID:24279383
Detection of specific IgA antibodies against a novel deamidated 8-Mer gliadin peptide in blood plasma samples from celiac patients. PMID:24278359
Substrate-driven mapping of the degradome by comparison of sequence logos. PMID:24244149
Cysteine cathepsins in neurological disorders. PMID:24234234
Sequence-derived structural features driving proteolytic processing. PMID:24227478
Biochemistry and physiological functions of ADAMTS7 metalloprotease. PMID:24222922
Global cellular response to chemotherapy-induced apoptosis. PMID:24171104
Biophysical characterization of a recombinant aminopeptidase II from the thermophilic bacterium Bacillus stearothermophilus. PMID:24165863
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. PMID:24157837
The structure of classical swine fever virus N(pro): a novel cysteine Autoprotease and zinc-binding protein involved in subversion of type I interferon induction. PMID:24146623
Fungal zinc metabolism and its connections to virulence. PMID:24133658
Small compound bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells. PMID:24118350
Comparative genomic analysis indicates that niche adaptation of terrestrial Flavobacteria is strongly linked to plant glycan metabolism. PMID:24086761
Specificity of a protein-protein interface: local dynamics direct substrate recognition of effector caspases. PMID:24085488
Increased Rate of Sporadic and Recurrent Rare Genic Copy Number Variants in Parkinson's Disease Among Ashkenazi Jews. PMID:24073418
Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes. PMID:24073280
A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. PMID:24060869
Biochemical and structural insights into mesotrypsin: an unusual human trypsin. PMID:24049668
The trypsin inhibitor panulirin regulates the prophenoloxidase-activating system in the spiny lobster Panulirus argus. PMID:24047891
Characterization of a new oxidant-stable serine protease isolated by functional metagenomics. PMID:24024096
The novel caspase-3 substrate Gap43 is involved in AMPA receptor endocytosis and long-term depression. PMID:24023391
The genome of the hydatid tapeworm Echinococcus granulosus. PMID:24013640
The genome of the alga-associated marine flavobacterium Formosa agariphila KMM 3901T reveals a broad potential for degradation of algal polysaccharides. PMID:23995932
SUMO rules: regulatory concepts and their implication in neurologic functions. PMID:23990202
The tick-derived anticoagulant madanin is processed by thrombin and factor Xa. PMID:23951260
Metaproteomics of cellulose methanisation under thermophilic conditions reveals a surprisingly high proteolytic activity. PMID:23949661
Analysis of the proteolysis of bioactive peptides using a peptidomics approach. PMID:23949379
A computational module assembled from different protease family motifs identifies PI PLC from Bacillus cereus as a putative prolyl peptidase with a serine protease scaffold. PMID:23940667
Potential link between biotic defense activation and recalcitrance to induction of somatic embryogenesis in shoot primordia from adult trees of white spruce (Picea glauca). PMID:23937238
The molecular components of the extracellular protein-degradation pathways of the ectomycorrhizal fungus Paxillus involutus. PMID:23902518
Proteolysis controls endogenous substance P levels. PMID:23894327
Structure of allergens and structure based epitope predictions. PMID:23891546
Proteolytic post-translational modification of proteins: proteomic tools and methodology. PMID:23887885
Evolution of the plasma and tissue kallikreins, and their alternative splicing isoforms. PMID:23874499
Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation. PMID:23849989
Bioinformatics perspective on rhomboid intramembrane protease evolution and function. PMID:23845876
Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data. PMID:23826350
The genome of tolypocladium inflatum: evolution, organization, and expression of the cyclosporin biosynthetic gene cluster. PMID:23818858
Regeneration of human dermis by a multi-headed peptide. PMID:23812301
Carbon availability triggers the decomposition of plant litter and assimilation of nitrogen by an ectomycorrhizal fungus. PMID:23788332
Proteolysis of recombinant proteins in bioengineered plant cells. PMID:23778319
Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. PMID:23776206
ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity. PMID:23754285
Mutational analysis of the Pseudomonas aeruginosa myovirus KZ morphogenetic protease gp175. PMID:23740980
A novel family of soluble minimal scaffolds provides structural insight into the catalytic domains of integral membrane metallopeptidases. PMID:23733187
Multiple classes of immune-related proteases associated with the cell death response in pepper plants. PMID:23696830
Pyrococcus horikoshii TET2 peptidase assembling process and associated functional regulation. PMID:23696647
Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence. PMID:23689588
Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport. PMID:23686857
Characterization of an M28 metalloprotease family member residing in the yeast vacuole. PMID:23679341
CLCAs - a family of metalloproteases of intriguing phylogenetic distribution and with cases of substituted catalytic sites. PMID:23671590
Crystal structures of the viral protease Npro imply distinct roles for the catalytic water in catalysis. PMID:23643950
X-ray structure analysis and characterization of AFUEI, an elastase inhibitor from Aspergillus fumigatus. PMID:23640894
Cleavage entropy as quantitative measure of protease specificity. PMID:23637583
Identification and prioritization of novel uncharacterized peptidases for biochemical characterization. PMID:23584835
Leucoagaricus gongylophorus produces diverse enzymes for the degradation of recalcitrant plant polymers in leaf-cutter ant fungus gardens. PMID:23584789
Biochemical characterization of VQ-VII, a cysteine peptidase with broad specificity, isolated from Vasconcellea quercifolia latex. PMID:23568402
A tunable, modular approach to fluorescent protease-activated reporters. PMID:23561537
Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases. PMID:23558682
Horizontal transfer of a subtilisin gene from plants into an ancestor of the plant pathogenic fungal genus Colletotrichum. PMID:23554975
High-affinity cyclic peptide matriptase inhibitors. PMID:23548907
Antigenic peptide trimming by ER aminopeptidases--insights from structural studies. PMID:23545452
Predominant archaea in marine sediments degrade detrital proteins. PMID:23535597
Sequencing and comparative analysis of the straw mushroom (Volvariella volvacea) genome. PMID:23526973
A pepper (Capsicum annuum L.) metacaspase 9 (Camc9) plays a role in pathogen-induced cell death in plants. PMID:23522353
Ultratight crystal packing of a 10 kDa protein. PMID:23519421
Parasite prolyl oligopeptidases and the challenge of designing chemotherapeuticals for Chagas disease, leishmaniasis and African trypanosomiasis. PMID:23514419
Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2. PMID:23506317
New types of metacaspases in phytoplankton reveal diverse origins of cell death proteases. PMID:23412383
Structural and functional analysis of the CspB protease required for Clostridium spore germination. PMID:23408892
Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad. PMID:23382230
De novo transcriptome sequencing and analysis for Venturia inaequalis, the devastating apple scab pathogen. PMID:23349770
High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome. PMID:23335997
SARConnect: A Tool to Interrogate the Connectivity Between Proteins, Chemical Structures and Activity Data. PMID:23308082
The role of cysteine proteinases and their inhibitors in the host-pathogen cross talk. PMID:23305363
RNA-seq-based metatranscriptomic and microscopic investigation reveals novel metalloproteases of Neobodo sp. as potential virulence factors for soft tunic syndrome in Halocynthia roretzi. PMID:23300657
Aspartic peptidases of human pathogenic trypanosomatids: perspectives and trends for chemotherapy. PMID:23298141
MycoProtease-DB: Useful resource for Mycobacterium tuberculosis complex and nontuberculous mycobacterial proteases. PMID:23275726
The DegraBase: a database of proteolysis in healthy and apoptotic human cells. PMID:23264352
Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector. PMID:23223529
Deubiquitinases as a signaling target of oxidative stress. PMID:23219552
Three-Dimensional Molecular Modeling of a Diverse Range of SC Clan Serine Proteases. PMID:23213528
Birth-and-death of KLK3 and KLK2 in primates: evolution driven by reproductive biology. PMID:23204305
BRENDA in 2013: integrated reactions, kinetic data, enzyme function data, improved disease classification: new options and contents in BRENDA. PMID:23203881
ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions. PMID:23193256
PeroxiBase: a database for large-scale evolutionary analysis of peroxidases. PMID:23180785
Osmoprotection of Bacillus subtilis through import and proteolysis of proline-containing peptides. PMID:23144141
Identification and function of proteolysis regulators in seminal fluid. PMID:23109270
Transcriptional profiles of mating-responsive genes from testes and male accessory glands of the Mediterranean fruit fly, Ceratitis capitata. PMID:23071645
Bioinformatics and expression analyses of the Ixodes scapularis tick cystatin family. PMID:23053911
Roles of proteolysis in regulation of GPCR function. PMID:23043558
Global identification of peptidase specificity by multiplex substrate profiling. PMID:23023596
Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection. PMID:22951933
An archaeal protein evolutionarily conserved in prokaryotes is a zinc-dependent metalloprotease. PMID:22950735
A putative role for amino acid permeases in sink-source communication of barley tissues uncovered by RNA-seq. PMID:22935196
Novel traits of Trichoderma predicted through the analysis of its secretome. PMID:22924408
Gene pyramiding of peptidase inhibitors enhances plant resistance to the spider mite Tetranychus urticae. PMID:22900081
Influence of point mutations on the stability, dimerization, and oligomerization of human cystatin C and its L68Q variant. PMID:22866027
Cloning and expression analysis of genes encoding lytic endopeptidases L1 and L5 from Lysobacter sp. strain XL1. PMID:22865082
A cathepsin F-like peptidase involved in barley grain protein mobilization, HvPap-1, is modulated by its own propeptide and by cystatins. PMID:22791822
Cysteine peptidases and their inhibitors in Tetranychus urticae: a comparative genomic approach. PMID:22784002
New lives for old: evolution of pseudoenzyme function illustrated by iRhoms. PMID:22781900
Crystal structure of the yeast metacaspase Yca1. PMID:22761449
Proteases, cystic fibrosis and the epithelial sodium channel (ENaC). PMID:22729487
Ultrahigh and high resolution structures and mutational analysis of monomeric Streptococcus pyogenes SpeB reveal a functional role for the glycine-rich C-terminal loop. PMID:22645124
Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target. PMID:22543039
A new class of SUMO proteases. PMID:22422001
Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. PMID:22356908
MEROPS: the peptidase database PubMed citations: 340.

340 articles citing: MEROPS: the peptidase database

Genome-Wide Association Study of Nucleotide Variants Associated with Resistance to Nine Antimicrobials in Mycoplasma bovis. PMID:35889084
Residual Level, Histology, and Blood Biochemistry of Tebuconazole: A Repeated Dose 28-Day Oral Toxicity Study in Pigs. PMID:35855269
Identification of Proteases and Protease Inhibitors in Seeds of the Recalcitrant Forest Tree Species Quercus ilex. PMID:35832232
Structure-Functional Characteristics of the Svx Protein-The Virulence Factor of the Phytopathogenic Bacterium Pectobacterium atrosepticum. PMID:35805920
A Dual Enrichment Strategy Provides Soil- and Digestate-Competent Nitrous Oxide-Respiring Bacteria for Mitigating Climate Forcing in Agriculture. PMID:35638872
Hololectin Interdomain Linker Determines Asparaginyl Endopeptidase-Mediated Maturation of Antifungal Hevein-Like Peptides in Oats. PMID:35620686
Cell-controlled dynamic surfaces for skeletal stem cell growth and differentiation. PMID:35581256
Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases. PMID:35513512
Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin. PMID:35408828
Genome Assembly and Genome Annotation of Leishmania martiniquensis Isolated from a Leishmaniasis Patient in Thailand. PMID:35371566
Bacterial Carboxyl-Terminal Processing Proteases Play Critical Roles in the Cell Envelope and Beyond. PMID:35293777
De Novo Genome Assembly of Stinkhorn Mushroom Clathrus columnatus (Basidiomycota, Fungi) Using Illumina and Nanopore Sequencing Data. PMID:35142541
Genomic insight into the scale specialization of the biological control agent Novius pumilus (Weise, 1892). PMID:35100986
Candidates for Repurposing as Anti-Virulence Agents Based on the Structural Profile Analysis of Microbial Collagenase Inhibitors. PMID:35056958
Pseudomonas aeruginosa C-Terminal Processing Protease CtpA Assembles into a Hexameric Structure That Requires Activation by a Spiral-Shaped Lipoprotein-Binding Partner. PMID:35038915
TcTI, a Kunitz-type trypsin inhibitor from cocoa associated with defense against pathogens. PMID:35027639
Heterologous production of active form of beta-lytic protease by Bacillus subtilis and improvement of staphylolytic activity by protein engineering. PMID:34963446
Structure-Function Characteristics of SARS-CoV-2 Proteases and Their Potential Inhibitors from Microbial Sources. PMID:34946083
Thioesterase enzyme families: Functions, structures, and mechanisms. PMID:34921469
A combined transcriptomic and proteomic analysis of chrysanthemum provides new insights into petal senescence. PMID:34918180
XDeathDB: a visualization platform for cell death molecular interactions. PMID:34907160
The economical lifestyle of CPR bacteria in groundwater allows little preference for environmental drivers. PMID:34906246
Genome-wide identification and characterization of legume T2 Ribonuclease gene family and analysis of GmaRNS9, a soybean T2 Ribonuclease gene, function in nodulation. PMID:34881158
TMPRSS3 Gene Variants With Implications for Auditory Treatment and Counseling. PMID:34868270
New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing. PMID:34827315
Enhancement of Activity and Thermostability of Keratinase From Pseudomonas aeruginosa CCTCC AB2013184 by Directed Evolution With Noncanonical Amino Acids. PMID:34733836
"The PLCP gene family of grapevine (Vitis vinifera L.): characterization and differential expression in response to Plasmopara Viticola". PMID:34717550
In vitro and in silico characterization of alkaline serine protease from Bacillus subtilis D9 recovered from Saudi Arabia. PMID:34703922
Proteinase inhibitors in legume herbivore defense: from natural to genetically engineered protectants. PMID:34674016
The Role of Streptococcal Cell-Envelope Proteases in Bacterial Evasion of the Innate Immune System. PMID:34649250
Genome-Wide Identification and Comparison of Cysteine Proteases in the Pollen Coat and Other Tissues in Maize. PMID:34630461
Direct and Indirect Interactions Promote Complexes of the Lipoprotein LbcA, the CtpA Protease and Its Substrates, and Other Cell Wall Proteins in Pseudomonas aeruginosa. PMID:34570626
Comparative Transcriptome and Endophytic Bacterial Community Analysis of Morchella conica SH. PMID:34354681
Human Single-Chain Antibodies That Neutralize Elastolytic Activity of Pseudomonas aeruginosa LasB. PMID:34204417
Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing. PMID:34153188
Papain-Like Cysteine Protease Gene Family in Fig (Ficus carica L.): Genome-Wide Analysis and Expression Patterns. PMID:34122493
Constitutive expression of Camelus bactrianus prochymosin B in Pichia pastoris. PMID:34113734
Large Clostridial Toxins: Mechanisms and Roles in Disease. PMID:34076506
The M35 Metalloprotease Effector FocM35_1 Is Required for Full Virulence of Fusarium oxysporum f. sp. cubense Tropical Race 4. PMID:34072465
Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases. PMID:34072295
PCSK9 Biology and Its Role in Atherothrombosis. PMID:34070931
Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation. PMID:33948354
Bacterial Gamma-Glutamyl Transpeptidase, an Emerging Biocatalyst: Insights Into Structure-Function Relationship and Its Biotechnological Applications. PMID:33897647
Brockarchaeota, a novel archaeal phylum with unique and versatile carbon cycling pathways. PMID:33893309
Recombinant Production and Characterization of an Extracellular Subtilisin-Like Serine Protease from Acinetobacter baumannii of Fermented Food Origin. PMID:33870461
Insights into Leishmania Molecules and Their Potential Contribution to the Virulence of the Parasite. PMID:33672776
The Tail-Specific Protease Is Important for Legionella pneumophila To Survive Thermal Stress in Water and inside Amoebae. PMID:33608288
Newly discovered Asgard archaea Hermodarchaeota potentially degrade alkanes and aromatics via alkyl/benzyl-succinate synthase and benzoyl-CoA pathway. PMID:33452484
Distribution of Mixotrophy and Desiccation Survival Mechanisms across Microbial Genomes in an Arid Biological Soil Crust Community. PMID:33436509
Propedia: a database for protein-peptide identification based on a hybrid clustering algorithm. PMID:33388027
Caspase-3 Cleaves Extracellular Vesicle Proteins During Auditory Brainstem Development. PMID:33281555
Trypanosoma cruzi Presenilin-Like Transmembrane Aspartyl Protease: Characterization and Cellular Localization. PMID:33212923
The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors. PMID:33137165
Rational approach toward COVID-19 main protease inhibitors via molecular docking, molecular dynamics simulation and free energy calculation. PMID:33077821
How to use the MEROPS database and website to help understand peptidase specificity. PMID:32920969
Whole-Genome Sequencing and Bioinformatics Analysis of Apiotrichum mycotoxinivorans: Predicting Putative Zearalenone-Degradation Enzymes. PMID:32849454
DRAM for distilling microbial metabolism to automate the curation of microbiome function. PMID:32766782
Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in Enterobacteriaceae. PMID:32708513
Master Sculptor at Work: Enteropathogenic Escherichia coli Infection Uniquely Modifies Mitochondrial Proteolysis during Its Control of Human Cell Death. PMID:32487743
The C-terminus of substrates is critical but not sufficient for their degradation by the Pseudomonas aeruginosa CtpA protease. PMID:32482720
Lysosomal Biology and Function: Modern View of Cellular Debris Bin. PMID:32375321
Identification and in silico structural and functional analysis of a trypsin-like protease from shrimp Macrobrachium carcinus. PMID:32351789
A pipeline for targeted metagenomics of environmental bacteria. PMID:32061258
Partial protection with a chimeric tetraspanin-leucine aminopeptidase subunit vaccine against Opisthorchis viverrini infection in hamsters. PMID:31991114
Short-Term Nitrogen Fertilization Affects Microbial Community Composition and Nitrogen Mineralization Functions in an Agricultural Soil. PMID:31836579
Rewiring of Cancer Cell Metabolism by Mitochondrial VDAC1 Depletion Results in Time-Dependent Tumor Reprogramming: Glioblastoma as a Proof of Concept. PMID:31661894
Predominance of Anaerobic, Spore-Forming Bacteria in Metabolically Active Microbial Communities from Ancient Siberian Permafrost. PMID:31152014
Asgard archaea capable of anaerobic hydrocarbon cycling. PMID:31015394
Genome-Wide Identification of Papain-Like Cysteine Proteases in Gossypium hirsutum and Functional Characterization in Response to Verticillium dahliae. PMID:30842780
Plant proteases during developmental programmed cell death. PMID:30793182
Phosphoproteomic analyses of kidneys of Atlantic salmon infected with Aeromonas salmonicida. PMID:30765835
Isolation and characterization of a tandem-repeated cysteine protease from the symbiotic dinoflagellate Symbiodinium sp. KB8. PMID:30703144
VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site. PMID:30657523
Computational characterization of the peptidome in transporter associated with antigen processing (TAP)-deficient cells. PMID:30645615
Salivary protease spectrum biomarkers of oral cancer. PMID:30602733
Role of Papain-Like Cysteine Proteases in Plant Development. PMID:30564252
Keratinolytic activity of Bacillus subtilis LFB-FIOCRUZ 1266 enhanced by whole-cell mutagenesis. PMID:30555768
Botulinum and Tetanus Neurotoxins. PMID:30388027
Comprehensive characterisation of the heterogeneity of adalimumab via charge variant analysis hyphenated on-line to native high resolution Orbitrap mass spectrometry. PMID:30296204
In silico characterization of the global Geobacillus and Parageobacillus secretome. PMID:30285747
A Novel Substance P-Based Hydrogel for Increased Wound Healing Efficiency. PMID:30200361
TLR2 Ligand Pam3CSK4 Regulates MMP-2/9 Expression by MAPK/NF-κB Signaling Pathways in Primary Brain Microvascular Endothelial Cells. PMID:30088235
Overexpression of a SDD1-Like Gene From Wild Tomato Decreases Stomatal Density and Enhances Dehydration Avoidance in Arabidopsis and Cultivated Tomato. PMID:30022991
A Proteolytic Complex Targets Multiple Cell Wall Hydrolases in Pseudomonas aeruginosa. PMID:30018106
Engineering Bacillus pumilus alkaline serine protease to increase its low-temperature proteolytic activity by directed evolution. PMID:29859069
Papain-like and legumain-like proteases in rice: genome-wide identification, comprehensive gene feature characterization and expression analysis. PMID:29764367
Type II Secretion-Dependent Aminopeptidase LapA and Acyltransferase PlaC Are Redundant for Nutrient Acquisition during Legionella pneumophila Intracellular Infection of Amoebas. PMID:29666285
Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi. PMID:29540755
Transcriptomic profiling of nematode parasites surviving vaccine exposure. PMID:29534987
Expression of trans-membrane serine protease 3 (TMPRSS3) in the human organ of Corti. PMID:29460002
The first dipeptidyl peptidase III from a thermophile: Structural basis for thermal stability and reduced activity. PMID:29420664
Simultaneous determination of doxorubicin and its dipeptide prodrug in mice plasma by HPLC with fluorescence detection. PMID:29403982
Transcriptional profiling of long non-coding RNAs in mantle of Crassostrea gigas and their association with shell pigmentation. PMID:29362405
Papain-like cysteine proteases in Carica papaya: lineage-specific gene duplication and expansion. PMID:29306330
A novel type I cystatin of parasite origin with atypical legumain-binding domain. PMID:29235483
A leptospiral AAA+ chaperone-Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis. PMID:29184154
Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters. PMID:28851275
Cartilage matrix remodelling differs by disease state and joint type. PMID:28836259
The detrimental impact of extracellular bacterial proteases on wound healing. PMID:28745010
Cloning and characterization of the first serine carboxypeptidase from a plant parasitic nematode, Radopholus similis. PMID:28684768
Multi-Approach Analysis for the Identification of Proteases within Birch Pollen. PMID:28677627
Identification of Tight-Binding Plasmepsin II and Falcipain 2 Inhibitors in Aqueous Extracts of Marine Invertebrates by the Combination of Enzymatic and Interaction-Based Assays. PMID:28430158
Post-transcriptional regulation of fruit ripening and disease resistance in tomato by the vacuolar protease SlVPE3. PMID:28270225
A novel subtilase inhibitor in plants shows structural and functional similarities to protease propeptides. PMID:28223360
Advanced Glycation End Products Inhibit the Proliferation of Human Umbilical Vein Endothelial Cells by Inhibiting Cathepsin D. PMID:28218663
Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI. PMID:28198362
A comparative genomic analysis of putative pathogenicity genes in the host-specific sibling species Colletotrichum graminicola and Colletotrichum sublineola. PMID:28073340
Characterization of a New S8 serine Protease from Marine Sedimentary Photobacterium sp. A5-7 and the Function of Its Protease-Associated Domain. PMID:28066343
Transcriptomic analysis reveals the flooding tolerant mechanism in flooding tolerant line and abscisic acid treated soybean. PMID:28012053
A genome-wide association study identifies a horizontally transferred bacterial surface adhesin gene associated with antimicrobial resistant strains. PMID:27892531
Pilot-Scale Production and Thermostability Improvement of the M23 Protease Pseudoalterin from the Deep Sea Bacterium Pseudoalteromonas sp. CF6-2. PMID:27869696
Functional Characterization of Propeptides in Plant Subtilases as Intramolecular Chaperones and Inhibitors of the Mature Protease. PMID:27451395
C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function. PMID:27382189
Survival trade-offs in plant roots during colonization by closely related beneficial and pathogenic fungi. PMID:27150427
A Colletotrichum graminicola mutant deficient in the establishment of biotrophy reveals early transcriptional events in the maize anthracnose disease interaction. PMID:26956617
Comparative Transcriptomic Exploration Reveals Unique Molecular Adaptations of Neuropathogenic Trichobilharzia to Invade and Parasitize Its Avian Definitive Host. PMID:26863542
The Pratylenchus penetrans Transcriptome as a Source for the Development of Alternative Control Strategies: Mining for Putative Genes Involved in Parasitism and Evaluation of in planta RNAi. PMID:26658731
Signatures of positive selection at hemopexin (PEX) domain of matrix metalloproteinase-9 (MMP-9) gene. PMID:26648034
Functional expression, purification, and biochemical properties of subtilase SprP from Pseudomonas aeruginosa. PMID:26175208
Diversity, Structures, and Collagen-Degrading Mechanisms of Bacterial Collagenolytic Proteases. PMID:26150451
Culture Condition Optimization and Pilot Scale Production of the M12 Metalloprotease Myroilysin Produced by the Deep-Sea Bacterium Myroides profundi D25. PMID:26132910
Tomato Sl3-MMP, a member of the Matrix metalloproteinase family, is required for disease resistance against Botrytis cinerea and Pseudomonas syringae pv. tomato DC3000. PMID:26070456
Substrate stereoselectivity of poly(Asp) hydrolase-1 capable of cleaving β-amide bonds as revealed by investigation of enzymatic hydrolysis of stereoisomeric β-tri(Asp)s. PMID:26054734
Carboxylesterase 2 as a Determinant of Response to Irinotecan and Neoadjuvant FOLFIRINOX Therapy in Pancreatic Ductal Adenocarcinoma. PMID:26025324
Studies on the molecular docking and amino Acid residues involving in recognition of substrate in proline iminopeptidase by site-directed mutagenesis. PMID:25957260
MJD and OTU deubiquitinating enzymes in Schistosoma mansoni. PMID:25924794
Peptidases compartmentalized to the Ascaris suum intestinal lumen and apical intestinal membrane. PMID:25569475
Identification of Dipeptidyl-Peptidase (DPP)5 and DPP7 in Porphyromonas endodontalis, Distinct from Those in Porphyromonas gingivalis. PMID:25494328
Comparative transcriptomics reveals striking similarities between the bovine and feline isolates of Tritrichomonas foetus: consequences for in silico drug-target identification. PMID:25374366
Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer. PMID:25333340
In silico insights into protein-protein interactions and folding dynamics of the saposin-like domain of Solanum tuberosum aspartic protease. PMID:25188221
The structure and specificity of the type III secretion system effector NleC suggest a DNA mimicry mechanism of substrate recognition. PMID:25040221
The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Clostridium difficile. PMID:25004975
Genome and transcriptome of the porcine whipworm Trichuris suis. PMID:24929829
The lone S41 family C-terminal processing protease in Staphylococcus aureus is localized to the cell wall and contributes to virulence. PMID:24928312
Genome-wide analysis of regulatory proteases sequences identified through bioinformatics data mining in Taenia solium. PMID:24899069
The yrpAB operon of Yersinia ruckeri encoding two putative U32 peptidases is involved in virulence and induced under microaerobic conditions. PMID:24865652
Optimization of fermentation conditions for the production of the M23 protease Pseudoalterin by deep-sea Pseudoalteromonas sp. CF6-2 with artery powder as an inducer. PMID:24743935
Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation. PMID:24713703
Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders. PMID:24659483
Architecture and function of metallopeptidase catalytic domains. PMID:24596965
Genome of the human hookworm Necator americanus. PMID:24441737
Characterization of a novel subtilisin-like protease myroicolsin from deep sea bacterium Myroides profundi D25 and molecular insight into its collagenolytic mechanism. PMID:24429289
Identification and characterization of prokaryotic dipeptidyl-peptidase 5 from Porphyromonas gingivalis. PMID:24398682
Elevated peptides in lung lavage fluid associated with bronchiolitis obliterans syndrome. PMID:24392140
Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function. PMID:24366681
Conservation and developmental expression of ubiquitin isopeptidases in Schistosoma mansoni. PMID:24271000
Substrate-driven mapping of the degradome by comparison of sequence logos. PMID:24244149
DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells. PMID:24210823
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. PMID:24157837
Biochemical and structural characterization of SplD protease from Staphylococcus aureus. PMID:24130791
Toward the discovery of inhibitors of babesipain-1, a Babesia bigemina cysteine protease: in vitro evaluation, homology modeling and molecular docking studies. PMID:24129820
Various conotoxin diversifications revealed by a venomic study of Conus flavidus. PMID:24126141
The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. PMID:24072711
ADAMTS-4 and biglycan are expressed at high levels and co-localize to podosomes during endothelial cell tubulogenesis in vitro. PMID:24051360
Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand β5. PMID:24036669
Chromosomal copy number variation, selection and uneven rates of recombination reveal cryptic genome diversity linked to pathogenicity. PMID:23966879
A compact viral processing proteinase/ubiquitin hydrolase from the OTU family. PMID:23966860
Analysis of the proteolysis of bioactive peptides using a peptidomics approach. PMID:23949379
A lover and a fighter: the genome sequence of an entomopathogenic nematode Heterorhabditis bacteriophora. PMID:23874975
Mutations in LRPAP1 are associated with severe myopia in humans. PMID:23830514
Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis. PMID:23811845
Phenylalanine 664 of dipeptidyl peptidase (DPP) 7 and Phenylalanine 671 of DPP11 mediate preference for P2-position hydrophobic residues of a substrate. PMID:23772391
Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T. PMID:23703618
Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence. PMID:23689588
No ancient DNA damage in Actinobacteria from the Neanderthal bone. PMID:23658776
Cleavage entropy as quantitative measure of protease specificity. PMID:23637583
Camel and bovine chymosin: the relationship between their structures and cheese-making properties. PMID:23633601
Cystatin C properties crucial for uptake and inhibition of intracellular target enzymes. PMID:23629651
Identification and prioritization of novel uncharacterized peptidases for biochemical characterization. PMID:23584835
Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities. PMID:23560081
Diversity of natural self-derived ligands presented by different HLA class I molecules in transporter antigen processing-deficient cells. PMID:23555621
Microbial diversity and biochemical potential encoded by thermal spring metagenomes derived from the Kamchatka Peninsula. PMID:23533327
New types of metacaspases in phytoplankton reveal diverse origins of cell death proteases. PMID:23412383
Genomic and secretomic analyses reveal unique features of the lignocellulolytic enzyme system of Penicillium decumbens. PMID:23383313
Nuclear legumain activity in colorectal cancer. PMID:23326369
Molecular cloning and immunochemical characterization of a new Japanese cedar pollen allergen homologous to plant subtilisin-like serine protease. PMID:23282945
A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets. PMID:23236535
Analysis of proteolytic processes and enzymatic activities in the generation of huntingtin n-terminal fragments in an HEK293 cell model. PMID:23236391
Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome. PMID:23233448
Stage-specific expression of protease genes in the apicomplexan parasite, Eimeria tenella. PMID:23216867
Three-Dimensional Molecular Modeling of a Diverse Range of SC Clan Serine Proteases. PMID:23213528
The origin and functional transition of P34. PMID:23211789
Molecular changes in Opisthorchis viverrini (Southeast Asian liver fluke) during the transition from the juvenile to the adult stage. PMID:23209858
PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites. PMID:23209700
Genome sequence of the protease-producing bacterium Rheinheimera nanhaiensis E407-8T, isolated from deep-sea sediment of the South China Sea. PMID:23209246
By their genes ye shall know them: genomic signatures of predatory bacteria. PMID:23190728
Structure of the catalytic domain of the Salmonella virulence factor SseI. PMID:23151626
Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. PMID:23112050
Crossover inhibition as an indicator of convergent evolution of enzyme mechanisms: a β-lactamase and a N-terminal nucleophile hydrolase. PMID:23098756
Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor. PMID:23093934
The Online Protein Processing Resource (TOPPR): a database and analysis platform for protein processing events. PMID:23093603
In vitro functional analyses of arrhythmogenic right ventricular cardiomyopathy-associated desmoglein-2-missense variations. PMID:23071725
Genome sequence of the button mushroom Agaricus bisporus reveals mechanisms governing adaptation to a humic-rich ecological niche. PMID:23045686
Elastolytic mechanism of a novel M23 metalloprotease pseudoalterin from deep-sea Pseudoalteromonas sp. CF6-2: cleaving not only glycyl bonds in the hydrophobic regions but also peptide bonds in the hydrophilic regions involved in cross-linking. PMID:23012370
Heart of endosymbioses: transcriptomics reveals a conserved genetic program among arbuscular mycorrhizal, actinorhizal and legume-rhizobial symbioses. PMID:22970303
Characterization of cDNAs encoding serine proteases and their transcriptional responses to Cry1Ab protoxin in the gut of Ostrinia nubilalis larvae. PMID:22952884
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10. PMID:22940918
Crystal structures of archaemetzincin reveal a moldable substrate-binding site. PMID:22937112
A novel virulence strategy for Pseudomonas aeruginosa mediated by an autotransporter with arginine-specific aminopeptidase activity. PMID:22927813
Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. PMID:22918439
The protein composition of the digestive fluid from the venus flytrap sheds light on prey digestion mechanisms. PMID:22891002
Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses. PMID:22885923
Proteinases as virulence factors in Leishmania spp. infection in mammals. PMID:22871236
Comparison of expression and enzymatic properties of Aspergillus oryzae lysine aminopeptidases ApsA and ApsB. PMID:22806190
Cure of hookworm infection with a cysteine protease inhibitor. PMID:22802972
Proteases, cystic fibrosis and the epithelial sodium channel (ENaC). PMID:22729487
Chemoselective hydroxyl group transformation: an elusive target. PMID:22695722
Differential secretome analysis reveals CST6 as a suppressor of breast cancer bone metastasis. PMID:22688893
The mammary gland-specific marsupial ELP and eutherian CTI share a common ancestral gene. PMID:22681678
The biology and therapeutic targeting of the proprotein convertases. PMID:22679642
The role of cystatins in tick physiology and blood feeding. PMID:22647711
Mining the Active Proteome of Arabidopsis thaliana. PMID:22639616
Modeling and structural analysis of PA clan serine proteases. PMID:22624962
Structural basis for specificity of propeptide-enzyme interaction in barley C1A cysteine peptidases. PMID:22615948
Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides. PMID:22586115
Elevated levels of fibrinogen-derived endogenous citrullinated peptides in synovial fluid of rheumatoid arthritis patients. PMID:22584083
Inferring serum proteolytic activity from LC-MS/MS data. PMID:22537011
Crystal structure of a Trypanosoma brucei metacaspase. PMID:22529389
Structural and functional characterization of microcin C resistance peptidase MccF from Bacillus anthracis. PMID:22516613
A novel and conserved protein AHO-3 is required for thermotactic plasticity associated with feeding states in Caenorhabditis elegans. PMID:22512337
Targeting proteases in cardiovascular diseases by mass spectrometry-based proteomics. PMID:22511707
Genetic analysis of 15 protein folding factors and proteases of the Escherichia coli cell envelope. PMID:22505681
Characterization of member of DUF1888 protein family, self-cleaving and self-assembling endopeptidase. PMID:22493430
Control of Entamoeba histolytica adherence involves metallosurface protease 1, an M8 family surface metalloprotease with homology to leishmanolysin. PMID:22451519
The role of Adams in Notch signaling. PMID:22399336
Subepithelial trypsin induces enteric nerve-mediated anion secretion by activating proteinase-activated receptor 1 in the mouse cecum. PMID:22389134
Coffee cysteine proteinases and related inhibitors with high expression during grain maturation and germination. PMID:22380654
Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics. PMID:22371507
Protease signalling: the cutting edge. PMID:22367392
Chlapsin, a chloroplastidial aspartic proteinase from the green algae Chlamydomonas reinhardtii. PMID:22349731
Evidence for conserved function of γ-glutamyltranspeptidase in Helicobacter genus. PMID:22348013
A novel extracellular metallopeptidase domain shared by animal host-associated mutualistic and pathogenic microbes. PMID:22299034
Role of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (HLA)-B7 class I antigen presentation. PMID:22298786
Anti-angiogenic properties of ADAMTS-4 in vitro. PMID:22264287
Surveying proteolytic processes in human cancer microenvironments by microdialysis and activity-based mass spectrometry. PMID:22262628
Profiling protease activities by dynamic proteomics workflows. PMID:22246865
A role in immunity for Arabidopsis cysteine protease RD21, the ortholog of the tomato immune protease C14. PMID:22238602
Metatranscriptomics reveals the diversity of genes expressed by eukaryotes in forest soils. PMID:22238585
Clostridium difficile toxins: mediators of inflammation. PMID:22237401
Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile. PMID:22232165
Trojan horse strategies used by pathogens to influence the small ubiquitin-like modifier (SUMO) system of host eukaryotic cells. PMID:22223032
Microbial and fungal protease inhibitors--current and potential applications. PMID:22218770
NtSCP1 from tobacco is an extracellular serine carboxypeptidase III that has an impact on cell elongation. PMID:22214816
Oral enzyme therapy for celiac sprue. PMID:22208988
Minimotif Miner 3.0: database expansion and significantly improved reduction of false-positive predictions from consensus sequences. PMID:22146221
Modeling and structural analysis of evolutionarily diverse S8 family serine proteases. PMID:22125392
A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity. PMID:22117220
TopFIND 2.0--linking protein termini with proteolytic processing and modifications altering protein function. PMID:22102574
InterPro in 2011: new developments in the family and domain prediction database. PMID:22096229
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. PMID:22086950
Highly specific protease-based approach for detection of porphyromonas gingivalis in diagnosis of periodontitis. PMID:22075590
Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety. PMID:22073285
The zinc-dependent protease activity of the botulinum neurotoxins. PMID:22069621
Ascaris suum draft genome. PMID:22031327
Proteases inhibition assessment on PC12 and NGF treated cells after oxygen and glucose deprivation reveals a distinct role for aspartyl proteases. PMID:22028798
Cysteine cathepsins: from structure, function and regulation to new frontiers. PMID:22024571
Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice. PMID:22022579
Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control. PMID:22004680
Genomics of the proteorhodopsin-containing marine flavobacterium Dokdonia sp. strain MED134. PMID:22003006
Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme. PMID:21995438
One-pot synthesis of diverse DL-configuration dipeptides by a Streptomyces D-stereospecific amidohydrolase. PMID:21948842
Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis. PMID:21931748
Partial genome assembly for a candidate division OP11 single cell from an anoxic spring (Zodletone Spring, Oklahoma). PMID:21908640
Asp- and Glu-specific novel dipeptidyl peptidase 11 of Porphyromonas gingivalis ensures utilization of proteinaceous energy sources. PMID:21896480
Asparagine peptide lyases: a seventh catalytic type of proteolytic enzymes. PMID:21832066
TopFIND, a knowledgebase linking protein termini with function. PMID:21822272
Interactions between coagulation and complement--their role in inflammation. PMID:21811895
Using the water signal to detect invisible exchanging protons in the catalytic triad of a serine protease. PMID:21809183
Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin. PMID:21805238
Structural analysis of papain-like NlpC/P60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites. PMID:21799766
Structural and sequence analysis of imelysin-like proteins implicated in bacterial iron uptake. PMID:21799754
Systematic analysis of protease gene expression in the rhesus macaque ovulatory follicle: metalloproteinase involvement in follicle rupture. PMID:21791558
Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis. PMID:21768393
Specific functions of lysosomal proteases in endocytic and autophagic pathways. PMID:21767668
CREST--a large and diverse superfamily of putative transmembrane hydrolases. PMID:21733186
Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality. PMID:21724843
The metabolic serine hydrolases and their functions in mammalian physiology and disease. PMID:21696217
Substrate specifity profiling of the Aspergillus fumigatus proteolytic secretome reveals consensus motifs with predominance of Ile/Leu and Phe/Tyr. PMID:21695046
Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. PMID:21693781
Structural determinants of limited proteolysis. PMID:21682278
Identification of ejaculated proteins in the house mouse (Mus domesticus) via isotopic labeling. PMID:21663664
Cathepsin proteases in Toxoplasma gondii. PMID:21660658
Draft genome sequencing and comparative analysis of Aspergillus sojae NBRC4239. PMID:21659486
A novel subtilase with NaCl-activated and oxidant-stable activity from Virgibacillus sp. SK37. PMID:21658261
EGY2, a chloroplast membrane metalloprotease, plays a role in hypocotyl elongation in Arabidopsis. PMID:21643750
Novel insights into the diversity of catabolic metabolism from ten haloarchaeal genomes. PMID:21633497
Structural and functional analyses reveal that Staphylococcus aureus antibiotic resistance factor HmrA is a zinc-dependent endopeptidase. PMID:21622555
WCI, a novel wheat chymotrypsin inhibitor: purification, primary structure, inhibitory properties and heterologous expression. PMID:21617989
Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing. PMID:21605378
The aspartic proteinase family of three Phytophthora species. PMID:21599950
Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. PMID:21596990
A snapshot of the Ixodes scapularis degradome. PMID:21596113
The N-terminal nucleophile serine of cephalosporin acylase executes the second autoproteolytic cleavage and acylpeptide hydrolysis. PMID:21576250
Mining a cathepsin inhibitor library for new antiparasitic drug leads. PMID:21572521
Expansion of type II CAAX proteases reveals evolutionary origin of γ-secretase subunit APH-1. PMID:21570408
A plant alternative to animal caspases: subtilisin-like proteases. PMID:21546909
Recombinant expression and functional analysis of proteases from Streptococcus pneumoniae, Bacillus anthracis, and Yersinia pestis. PMID:21545736
Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinase. PMID:21543324
Roles of cysteine proteases Cwp84 and Cwp13 in biogenesis of the cell wall of Clostridium difficile. PMID:21531808
Cloning of a novel collagenase gene from the gram-negative bacterium Grimontia (Vibrio) hollisae 1706B and its efficient expression in Brevibacillus choshinensis. PMID:21515782
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. PMID:21478864
dbOGAP - an integrated bioinformatics resource for protein O-GlcNAcylation. PMID:21466708
Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm. PMID:21466698
Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing. PMID:21454591
Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. PMID:21439629
A portrait of the transcriptome of the neglected trematode, Fasciola gigantica--biological and biotechnological implications. PMID:21408104
An alternative view of the proposed alternative activities of hemopexin. PMID:21404362
An EST-based analysis identifies new genes and reveals distinctive gene expression features of Coffea arabica and Coffea canephora. PMID:21303543
A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones. PMID:21299233
Crystal structure of a viral protease intramolecular acyl-enzyme complex: insights into cis-cleavage at the VP4/VP3 junction of Tellina birnavirus. PMID:21288899
Peptide length and leaving-group sterics influence potency of peptide phosphonate protease inhibitors. PMID:21276938
Fungal proteases and their pathophysiological effects. PMID:21259054
Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. PMID:21247460
Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease. PMID:21245344
Anti-protease and immunomodulatory activities of bacteria associated with Caribbean sponges. PMID:21222136
Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease. PMID:21220481
Expression, purification and crystallization of VP4 protease from Tellina virus 1. PMID:21206051
Giardia duodenalis 14-3-3 protein is polyglycylated by a tubulin tyrosine ligase-like member and deglycylated by two metallocarboxypeptidases. PMID:21135098
Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner. PMID:21133893
Tissue dissociation enzymes for isolating human islets for transplantation: factors to consider in setting enzyme acceptance criteria. PMID:21116222
Bovipain-2, the falcipain-2 ortholog, is expressed in intraerythrocytic stages of the tick-transmitted hemoparasite Babesia bovis. PMID:21092313
Concept and application of a computational vaccinology workflow. PMID:21067549
Mechanisms of macromolecular protease inhibitors. PMID:21053238
ThYme: a database for thioester-active enzymes. PMID:21045059
The Gypsy Database (GyDB) of mobile genetic elements: release 2.0. PMID:21036865
Global and targeted proteomics in developing jack bean (Canavalia ensiformis) seedlings: an investigation of urease isoforms mobilization in early stages of development. PMID:20978823
TagA is a secreted protease of Vibrio cholerae that specifically cleaves mucin glycoproteins. PMID:20966091
The core genome of the anaerobic oral pathogenic bacterium Porphyromonas gingivalis. PMID:20920246
Flexibility of the thrombin-activatable fibrinolysis inhibitor pro-domain enables productive binding of protein substrates. PMID:20880845
Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin. PMID:20861008
MatrixDB, the extracellular matrix interaction database. PMID:20852260
Effect of protease inhibitors on the quantitative and qualitative assessment of oral microorganisms. PMID:20831596
Crystallization and preliminary X-ray studies of the C-terminal domain of Mycobacterium tuberculosis LexA. PMID:20823535
The exquisite structure and reaction mechanism of bacterial Pz-peptidase A toward collagenous peptides: X-ray crystallographic structure analysis of PZ-peptidase a reveals differences from mammalian thimet oligopeptidase. PMID:20817732
Increased expression of cysteine cathepsins in ovarian tissue from chickens with ovarian cancer. PMID:20727192
Structure-function analysis of the short splicing variant carboxypeptidase encoded by Drosophila melanogaster silver. PMID:20600119
Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase. PMID:20540760
Non-homologous isofunctional enzymes: a systematic analysis of alternative solutions in enzyme evolution. PMID:20433725
Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study. PMID:20147750
Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors PubMed citations: 274.

274 articles citing: Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors

Protease Activity Analysis: A Toolkit for Analyzing Enzyme Activity Data. PMID:35874224
Senescence-associated proteins and nitrogen remobilization in grain filling under drought stress condition. PMID:35819732
Crystal structure of Grimontia hollisae collagenase provides insights into its novel substrate specificity toward collagen. PMID:35679897
Identification of Cognate Protease/Substrate Pairs by Use of Class-Specific Inhibitors. PMID:35583773
Riemerella anatipestifer T9SS Effector SspA Functions in Bacterial Virulence and Defending Natural Host Immunity. PMID:35575548
Functional Analysis of the Endopeptidase and Holin From Planktothrix agardhii Cyanophage PaV-LD. PMID:35572663
Contribution of proteases to the hallmarks of aging and to age-related neurodegeneration. PMID:35349763
Genome Analysis of the Broad Host Range Necrotroph Nalanthamala psidii Highlights Genes Associated With Virulence. PMID:35283890
Cyclobutanes in Small-Molecule Drug Candidates. PMID:35263505
Antioxidant and Antimicrobial Peptides Derived from Food Proteins. PMID:35209132
Fungal Proteases as Emerging Biocatalysts to Meet the Current Challenges and Recent Developments in Biomedical Therapies: An Updated Review. PMID:35205863
IMA Genome - F16 : Draft genome assemblies of Fusarium marasasianum, Huntiella abstrusa, two Immersiporthe knoxdaviesiana isolates, Macrophomina pseudophaseolina, Macrophomina phaseolina, Naganishia randhawae, and Pseudocercospora cruenta. PMID:35197126
An estimate of the deepest branches of the tree of life from ancient vertically evolving genes. PMID:35190025
METABOLIC: high-throughput profiling of microbial genomes for functional traits, metabolism, biogeochemistry, and community-scale functional networks. PMID:35172890
Improving Protein Quantity and Quality-The Next Level of Plant Molecular Farming. PMID:35163249
Probabilistic Graphical Models Applied to Biological Networks. PMID:35113399
Genomic insights into versatile lifestyle of three new bacterial candidate phyla. PMID:35060074
Iron dysregulation in COVID-19 and reciprocal evolution of SARS-CoV-2: Natura nihil frustra facit. PMID:34997606
The genome of the zebra mussel, Dreissena polymorpha: a resource for comparative genomics, invasion genetics, and biocontrol. PMID:34897429
Genetic determinants of endophytism in the Arabidopsis root mycobiome. PMID:34893598
Serine proteases activity in miracidia of Fasciola hepatica and effects of chemical and herbal inhibitors. PMID:34815839
VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center. PMID:34718728
Thinopyrum intermedium TiAP1 interacts with a chitin deacetylase from Blumeria graminis f. sp. tritici and increases the resistance to Bgt in wheat. PMID:34651397
Three Distinct Proteases Are Responsible for Overall Cell Surface Proteolysis in Streptococcus thermophilus. PMID:34550764
Chromosome-Level Genome Sequence of Aspergillus chevalieri M1, Isolated from Katsuobushi. PMID:34528823
A Structure Based Study of Selective Inhibition of Factor IXa over Factor Xa. PMID:34500804
Chromosome-Level Genome Sequence of Aspergillus puulaauensis MK2, a Fungus Isolated from a Dead Hard Tick. PMID:34498921
A Chromosome-Scale Assembly of the Wheat Leaf Rust Pathogen Puccinia triticina Provides Insights Into Structural Variations and Genetic Relationships With Haplotype Resolution. PMID:34394053
Expanding Asgard members in the domain of Archaea sheds new light on the origin of eukaryotes. PMID:34378142
Chromosome-Level Genome Sequence of the Black Koji Fungus Aspergillus luchuensis RIB2601. PMID:34292062
Diploidy within a Haploid Genus of Entomopathogenic Fungi. PMID:34247231
ERAP1 binds peptide C-termini of different sequences and/or lengths by a common recognition mechanism. PMID:34247019
Papain-Like Cysteine Protease Gene Family in Fig (Ficus carica L.): Genome-Wide Analysis and Expression Patterns. PMID:34122493
The effects of plant cysteine proteinases on the nematode cuticle. PMID:34090505
Genome sequence analysis of the beneficial Bacillus subtilis PTA-271 isolated from a Vitis vinifera (cv. Chardonnay) rhizospheric soil: assets for sustainable biocontrol. PMID:33902737
Genome analysis provides insights into the biocontrol ability of Mitsuaria sp. strain TWR114. PMID:33880605
Eudiplozoon nipponicum (Monogenea, Diplozoidae) and its adaptation to haematophagy as revealed by transcriptome and secretome profiling. PMID:33858339
Cellular engineering of plant cells for improved therapeutic protein production. PMID:33837823
Architecturally complex O-glycopeptidases are customized for mucin recognition and hydrolysis. PMID:33658366
Genome sequences of Tropheus moorii and Petrochromis trewavasae, two eco-morphologically divergent cichlid fishes endemic to Lake Tanganyika. PMID:33619328
Structure, function, and substrates of Clp AAA+ protease systems in cyanobacteria, plastids, and apicoplasts: A comparative analysis. PMID:33497624
An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease. PMID:33466870
S. mansoni SmKI-1 Kunitz-domain: Leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity. PMID:33465126
Gene expression profiling of protease and non-protease genes in Trichophyton mentagrophytes isolates from dermatophytosis patients by qRT-PCR analysis. PMID:33432046
Diversity and Genomic Characterization of a Novel Parvarchaeota Family in Acid Mine Drainage Sediments. PMID:33408709
Protein quality control and regulated proteolysis in the genome-reduced organism Mycoplasma pneumoniae. PMID:33320415
Quantitative comparison of the biomass-degrading enzyme repertoires of five filamentous fungi. PMID:33219291
Cycling in degradation of organic polymers and uptake of nutrients by a litter-degrading fungus. PMID:33140552
Structural evidence for a proline-specific glycopeptide recognition domain in an O-glycopeptidase. PMID:33030205
Genomic Signatures of Coevolution between Nonmodel Mammals and Parasitic Roundworms. PMID:32960966
Genome-Centric Metagenomic Insights into the Impact of Alkaline/Acid and Thermal Sludge Pretreatment on the Microbiome in Digestion Sludge. PMID:32948522
Gene expression during bacterivorous growth of a widespread marine heterotrophic flagellate. PMID:32920602
Processing and Formation of Bioactive CLE40 Peptide Are Controlled by Posttranslational Proline Hydroxylation. PMID:32907884
Promiscuous Enzyme Activity as a Driver of Allo and Iso Convergent Evolution, Lessons from the β-Lactamases. PMID:32872436
Multiplexed Probing of Proteolytic Enzymes Using Mass Cytometry-Compatible Activity-Based Probes. PMID:32870676
Genomics and Virulence of Fonsecaea pugnacius, Agent of Disseminated Chromoblastomycosis. PMID:32849816
Undinarchaeota illuminate DPANN phylogeny and the impact of gene transfer on archaeal evolution. PMID:32770105
Catabolism and interactions of uncultured organisms shaped by eco-thermodynamics in methanogenic bioprocesses. PMID:32709258
Comparative genomics and transcriptomics of 4 Paragonimus species provide insights into lung fluke parasitism and pathogenesis. PMID:32687148
Biochemical Characterization of Human Retroviral-Like Aspartic Protease 1 (ASPRV1). PMID:32640672
The Effects of pH and Temperature on Cysteine Protease (Cathepsin B) Activity in Miracidia and Eggs of Fasciola hepatica. PMID:32595713
Long-Read-Based de novo Genome Assembly and Comparative Genomics of the Wheat Leaf Rust Pathogen Puccinia triticina Identifies Candidates for Three Avirulence Genes. PMID:32582280
The Arg/N-Degron Pathway-A Potential Running Back in Fine-Tuning the Inflammatory Response? PMID:32545869
Conserved white-rot enzymatic mechanism for wood decay in the Basidiomycota genus Pycnoporus. PMID:32531032
Transcriptome-Wide Comparisons and Virulence Gene Polymorphisms of Host-Associated Genotypes of the Cnidarian Parasite Ceratonova shasta in Salmonids. PMID:32467979
Whole Genome Sequencing and Comparative Genomic Analyses of Lysinibacillus pakistanensis LZH-9, a Halotolerant Strain with Excellent COD Removal Capability. PMID:32408484
Genome diversification in globally distributed novel marine Proteobacteria is linked to environmental adaptation. PMID:32393808
Novel Apoptotic Mediators Identified by Conservation of Vertebrate Caspase Targets. PMID:32326640
The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway. PMID:32297855
Distinct Life Histories Impact Dikaryotic Genome Evolution in the Rust Fungus Puccinia striiformis Causing Stripe Rust in Wheat. PMID:32271913
Draft Genome Sequence of the Yeast Rhodotorula sp. Strain CCFEE 5036, Isolated from McMurdo Dry Valleys, Antarctica. PMID:32241854
Diverse Asgard archaea including the novel phylum Gerdarchaeota participate in organic matter degradation. PMID:32201928
Brown marmorated stink bug, Halyomorpha halys (Stål), genome: putative underpinnings of polyphagy, insecticide resistance potential and biology of a top worldwide pest. PMID:32171258
Optimised production of an anti-fungal antibody in Solanaceae hairy roots to develop new formulations against Candida albicans. PMID:32164664
Comparative genomics applied to Mucor species with different lifestyles. PMID:32039703
Community-intrinsic properties enhance keratin degradation from bacterial consortia. PMID:32004342
Isolation of an archaeon at the prokaryote-eukaryote interface. PMID:31942073
An M29 Aminopeptidase from Listeria Monocytogenes Contributes to In Vitro Bacterial Growth but not to Intracellular Infection. PMID:31941013
Genome- and Community-Level Interaction Insights into Carbon Utilization and Element Cycling Functions of Hydrothermarchaeota in Hydrothermal Sediment. PMID:31911466
Ligand-induced conformational selection predicts the selectivity of cysteine protease inhibitors. PMID:31856175
Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples. PMID:31803426
Considerations on the Rational Design of Covalently Conjugated Cell-Penetrating Peptides (CPPs) for Intracellular Delivery of Proteins: A Guide to CPP Selection Using Glucarpidase as the Model Cargo Molecule. PMID:31779220
The genetic basis of adaptive evolution in parasitic environment from the Angiostrongylus cantonensis genome. PMID:31751335
Comparative transcriptomics of Gymnosporangium spp. teliospores reveals a conserved genetic program at this specific stage of the rust fungal life cycle. PMID:31597570
Solvation Free Energy as a Measure of Hydrophobicity: Application to Serine Protease Binding Interfaces. PMID:31589427
Vibrio Proteases for Biomedical Applications: Modulating the Proteolytic Secretome of V. alginolyticus and V. parahaemolyticus for Improved Enzymes Production. PMID:31554228
Exploring the effects of operational mode and microbial interactions on bacterial community assembly in a one-stage partial-nitritation anammox reactor using integrated multi-omics. PMID:31462278
Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex. PMID:31455655
The Oxymonad Genome Displays Canonical Eukaryotic Complexity in the Absence of a Mitochondrion. PMID:31387118
The Farmed Atlantic Salmon (Salmo salar) Skin-Mucus Proteome and Its Nutrient Potential for the Resident Bacterial Community. PMID:31284681
Site-specific cleavage of bacterial MucD by secreted proteases mediates antibacterial resistance in Arabidopsis. PMID:31253808
New insights into structural and functional relationships between LonA proteases and ClpB chaperones. PMID:31237118
Isolation and characterization of a thermophilic sulfur- and iron-reducing thaumarchaeote from a terrestrial acidic hot spring. PMID:31171857
Nanoparticle exposure driven circulating bioactive peptidome causes systemic inflammation and vascular dysfunction. PMID:31142334
Genome description of Phlebia radiata 79 with comparative genomics analysis on lignocellulose decomposition machinery of phlebioid fungi. PMID:31138126
Collagenolytic matrix metalloproteinases antagonize proteinase-activated receptor-2 activation, providing insights into extracellular matrix turnover. PMID:31110047
Structural comparison strengthens the higher-order classification of proteases related to chymotrypsin. PMID:31100077
Identification and characterization of the lamprey cathepsin genes. PMID:31089760
Sulfate-Reducing Bacteria That Produce Exopolymers Thrive in the Calcifying Zone of a Hypersaline Cyanobacterial Mat. PMID:31068923
Proposal of the reverse flow model for the origin of the eukaryotic cell based on comparative analyses of Asgard archaeal metabolism. PMID:30936488
Cancer vaccines: designing artificial synthetic long peptides to improve presentation of class I and class II T cell epitopes by dendritic cells. PMID:30906653
The Dual Prey-Inactivation Strategy of Spiders-In-Depth Venomic Analysis of Cupiennius salei. PMID:30893800
Plant Serine Protease Inhibitors: Biotechnology Application in Agriculture and Molecular Farming. PMID:30884891
Genomic and metatranscriptomic analyses of carbon remineralization in an Antarctic polynya. PMID:30786927
Bioinformatic discovery of a toxin family in Chryseobacterium piperi with sequence similarity to botulinum neurotoxins. PMID:30733520
Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. PMID:30700553
Customizing Morphology, Size, and Response Kinetics of Matrix Metalloproteinase-Responsive Nanostructures by Systematic Peptide Design. PMID:30689363
Novel pseudo-aspartic peptidase from the midgut of the tick Rhipicephalus microplus. PMID:30679545
Identification of a Novel Elastin-Degrading Enzyme from the Fish Pathogen Flavobacterium psychrophilum. PMID:30635380
Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-κB. PMID:30619349
Evolutionary Features in the Structure and Function of Bacterial Toxins. PMID:30609803
Kn-Ba: a novel serine protease isolated from Bitis arietans snake venom with fibrinogenolytic and kinin-releasing activities. PMID:30564275
Role of Papain-Like Cysteine Proteases in Plant Development. PMID:30564252
Identification and partial characterization of a novel serpin from Eudiplozoon nipponicum (Monogenea, Polyopisthocotylea). PMID:30516130
Genomic and transcriptomic insights into the ecology and metabolism of benthic archaeal cosmopolitan, Thermoprofundales (MBG-D archaea). PMID:30514872
Expansive microbial metabolic versatility and biodiversity in dynamic Guaymas Basin hydrothermal sediments. PMID:30479325
Comparative evolutionary histories of fungal proteases reveal gene gains in the mycoparasitic and nematode-parasitic fungus Clonostachys rosea. PMID:30445903
Proteolysis of histidine kinase VgrS inhibits its autophosphorylation and promotes osmostress resistance in Xanthomonas campestris. PMID:30442885
Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities. PMID:30424533
Genome properties in 2019: a new companion database to InterPro for the inference of complete functional attributes. PMID:30364992
Analysis of impact metrics for the Protein Data Bank. PMID:30325351
Doxorubicin induces caspase-mediated proteolysis of KV7.1. PMID:30302399
Leveraging single-cell genomics to expand the fungal tree of life. PMID:30297742
Spatial Distribution of Endogenous Tissue Protease Activity in Gastric Carcinoma Mapped by MALDI Mass Spectrometry Imaging. PMID:30293968
Proteases: Pivot Points in Functional Proteomics. PMID:30276748
Sugar Promotes Feeding in Flies via the Serine Protease Homolog scarface. PMID:30232002
Thermus sediminis sp. nov., a thiosulfate-oxidizing and arsenate-reducing organism isolated from Little Hot Creek in the Long Valley Caldera, California. PMID:30219948
Genomic insights into host adaptation between the wheat stripe rust pathogen (Puccinia striiformis f. sp. tritici) and the barley stripe rust pathogen (Puccinia striiformis f. sp. hordei). PMID:30208837
The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health. PMID:30186247
Reflections on the evolution of the vertebrate tissue inhibitors of metalloproteinases. PMID:30125136
Early Diverging Insect-Pathogenic Fungi of the Order Entomophthorales Possess Diverse and Unique Subtilisin-Like Serine Proteases. PMID:30111619
The selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteases. PMID:30075004
Effect of Active Site Pocket Structure Modification of D-Stereospecific Amidohydrolase on the Recognition of Stereospecific and Hydrophobic Substrates. PMID:30051300
Plasminogen activation triggers transthyretin amyloidogenesis in vitro. PMID:30018138
Genomic and transcriptomic comparison of Aspergillus oryzae strains: a case study in soy sauce koji fermentation. PMID:29978373
Cadherin-6B proteolytic N-terminal fragments promote chick cranial neural crest cell delamination by regulating extracellular matrix degradation. PMID:29958899
Trichomonas vaginalis metalloproteinase TvMP50 is a monomeric Aminopeptidase P-like enzyme. PMID:29936696
Comparative Genomics Reveals Evidence of Genome Reduction and High Extracellular Protein Degradation Potential in Kangiella. PMID:29930545
Two New Secreted Proteases Generate a Casein-Derived Antimicrobial Peptide in Bacillus cereus Food Born Isolate Leading to Bacterial Competition in Milk. PMID:29915567
iProt-Sub: a comprehensive package for accurately mapping and predicting protease-specific substrates and cleavage sites. PMID:29897410
Cathepsins: Proteases that are vital for survival but can also be fatal. PMID:29885636
Complete Genomic Sequence of Pseudoalteromonas sp. Strain SAO4-4, a Protease-Producing Bacterium Isolated from Seawater of the Atlantic Ocean. PMID:29853496
Fermentative Spirochaetes mediate necromass recycling in anoxic hydrocarbon-contaminated habitats. PMID:29849169
In vitro pepsin digestibility and amino acid composition in soluble and residual fractions of hydrolyzed chicken feathers. PMID:29796647
Electrostatic recognition in substrate binding to serine proteases. PMID:29785722
Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease. PMID:29777136
The effect of DPP-4 inhibition to improve functional outcome after stroke is mediated by the SDF-1α/CXCR4 pathway. PMID:29776406
The extracellular proteases produced by Vibrio parahaemolyticus. PMID:29752585
Metallopeptidases of Toxoplasma gondii: in silico identification and gene expression. PMID:29737275
Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes. PMID:29719685
Dehydration Stress Contributes to the Enhancement of Plant Defense Response and Mite Performance on Barley. PMID:29681917
Comparative genomics provides insights into the lifestyle and reveals functional heterogeneity of dark septate endophytic fungi. PMID:29679020
Regulated Proteolysis in Bacteria. PMID:29648875
A Biofilm Matrix-Associated Protease Inhibitor Protects Pseudomonas aeruginosa from Proteolytic Attack. PMID:29636440
Soluble expression of an amebic cysteine protease in the cytoplasm of Escherichia coli SHuffle Express cells and purification of active enzyme. PMID:29615011
Impact of Subolesin and Cystatin Knockdown by RNA Interference in Adult Female Haemaphysalis longicornis (Acari: Ixodidae) on Blood Engorgement and Reproduction. PMID:29614797
TAILS N-terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation. PMID:29593093
Intraspecific comparative genomics of isolates of the Norway spruce pathogen (Heterobasidion parviporum) and identification of its potential virulence factors. PMID:29580224
Potential Activities of Freshwater Exo- and Endo-Acting Extracellular Peptidases in East Tennessee and the Pocono Mountains. PMID:29559961
Quantitative peptidomics of endogenous peptides involved in TGF-β1-induced epithelial mesenchymal transition of renal epithelial cells. PMID:29531806
Structural changes of TasA in biofilm formation of Bacillus subtilis. PMID:29531041
Cysteine peptidases of Eudiplozoon nipponicum: a broad repertoire of structurally assorted cathepsins L in contrast to the scarcity of cathepsins B in an invasive species of haematophagous monogenean of common carp. PMID:29510760
Genome-reconstruction for eukaryotes from complex natural microbial communities. PMID:29496730
Biochemical and MALDI-TOF Mass Spectrometric Characterization of a Novel Native and Recombinant Cystine Knot Miniprotein from Solanum tuberosum subsp. andigenum cv. Churqueña. PMID:29495576
Ten Prominent Host Proteases in Plant-Pathogen Interactions. PMID:29495279
A Near-Complete Haplotype-Phased Genome of the Dikaryotic Wheat Stripe Rust Fungus Puccinia striiformis f. sp. tritici Reveals High Interhaplotype Diversity. PMID:29463659
De Novo Assembly and Phasing of Dikaryotic Genomes from Two Isolates of Puccinia coronata f. sp. avenae, the Causal Agent of Oat Crown Rust. PMID:29463655
Divergent N Deficiency-Dependent Senescence and Transcriptome Response in Developmentally Old and Young Brassica napus Leaves. PMID:29449851
SACCHARIS: an automated pipeline to streamline discovery of carbohydrate active enzyme activities within polyspecific families and de novo sequence datasets. PMID:29441125
Crystal structures of a bacterial dipeptidyl peptidase IV reveal a novel substrate recognition mechanism distinct from that of mammalian orthologues. PMID:29426867
Schistosoma mansoni SmKI-1 serine protease inhibitor binds to elastase and impairs neutrophil function and inflammation. PMID:29425229
Structural basis of ribosomal peptide macrocyclization in plants. PMID:29384475
Genome-wide comparative analysis of papain-like cysteine protease family genes in castor bean and physic nut. PMID:29321580
Comparative genomic analyses reveal the features for adaptation to nematodes in fungi. PMID:29315395
An Alternative Nested Reading Frame May Participate in the Stress-Dependent Expression of a Plant Gene. PMID:29312392
Autophagy is activated and involved in cell death with participation of cathepsins during stress-induced microspore embryogenesis in barley. PMID:29309624
Metabolic versatility of small archaea Micrarchaeota and Parvarchaeota. PMID:29222443
Comparative genomic analysis of Brevibacterium strains: insights into key genetic determinants involved in adaptation to the cheese habitat. PMID:29216827
The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover. PMID:29196708
Comparative Genomics of Pathogenic and Nonpathogenic Beetle-Vectored Fungi in the Genus Geosmithia. PMID:29186370
Sugar Metabolism of the First Thermophilic Planctomycete Thermogutta terrifontis: Comparative Genomic and Transcriptomic Approaches. PMID:29163426
Prochemerin cleavage by factor XIa links coagulation and inflammation. PMID:29158361
Minimotif Miner 4: a million peptide minimotifs and counting. PMID:29140456
Insights from the Genomes of Microbes Thriving in Uranium-Enriched Sediments. PMID:29128951
Comparative Genome Analysis Reveals Adaptation to the Ectophytic Lifestyle of Sooty Blotch and Flyspeck Fungi. PMID:29126189
Impaired expression of CXCL5 and matrix metalloproteinases in the lungs of mice with high susceptibility to Streptococcus pneumoniae infection. PMID:29119707
Insights into the molecular evolution of peptidase inhibitors in arthropods. PMID:29108008
Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides thetaiotaomicron. PMID:29095893
The modular nature of bradykinin-potentiating peptides isolated from snake venoms. PMID:29090005
PULDB: the expanded database of Polysaccharide Utilization Loci. PMID:29088389
PROSPERous: high-throughput prediction of substrate cleavage sites for 90 proteases with improved accuracy. PMID:29069280
Comparative Genomics of Sibling Species of Fonsecaea Associated with Human Chromoblastomycosis. PMID:29062304
The Enigmatic Genome of an Obligate Ancient Spiroplasma Symbiont in a Hadal Holothurian. PMID:29054873
Kunitz Proteinase Inhibitors Limit Water Stress Responses in White Clover (Trifolium repens L.) Plants. PMID:29046678
Systematic classification of the His-Me finger superfamily. PMID:29040665
Phage-assisted continuous evolution of proteases with altered substrate specificity. PMID:29038472
Expression of Collagenase is Regulated by the VarS/VarA Two-Component Regulatory System in Vibrio alginolyticus. PMID:28993850
Expression of matrix metalloproteinase 12 is highly specific for non-proliferating invasive trophoblasts in the first trimester and temporally regulated by oxygen-dependent mechanisms including HIF-1A. PMID:28990117
Block-based characterization of protease specificity from substrate sequence profile. PMID:28974219
The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases. PMID:28966893
Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN). PMID:28964831
HvPap-1 C1A Protease Participates Differentially in the Barley Response to a Pathogen and an Herbivore. PMID:28955371
The Plastid and Mitochondrial Peptidase Network in Arabidopsis thaliana: A Foundation for Testing Genetic Interactions and Functions in Organellar Proteostasis. PMID:28947489
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity. PMID:28933778
Apophysomyces variabilis: draft genome sequence and comparison of predictive virulence determinants with other medically important Mucorales. PMID:28923009
Dermatophagoides pteronyssinus lytFM encoding an NlpC/P60 endopeptidase is also present in mite-associated bacteria that express LytFM variants. PMID:28904857
Sensitive in vivo Visualization of Breast Cancer Using Ratiometric Protease-activatable Fluorescent Imaging Agent, AVB-620. PMID:28900516
Endolysosomal Degradation of Allergenic Ole e 1-Like Proteins: Analysis of Proteolytic Cleavage Sites Revealing T Cell Epitope-Containing Peptides. PMID:28812992
High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti. PMID:28777090
Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation. PMID:28768771
Papain-like cysteine protease encoding genes in rubber (Hevea brasiliensis): comparative genomics, phylogenetic, and transcriptional profiling analysis. PMID:28752264
Protease cleavage site fingerprinting by label-free in-gel degradomics reveals pH-dependent specificity switch of legumain. PMID:28733325
Knowledge-transfer learning for prediction of matrix metalloprotease substrate-cleavage sites. PMID:28720874
Salivary Tick Cystatin OmC2 Targets Lysosomal Cathepsins S and C in Human Dendritic Cells. PMID:28713775
Multi-Approach Analysis for the Identification of Proteases within Birch Pollen. PMID:28677627
Degradation of Incretins and Modulation of Blood Glucose Levels by Periodontopathic Bacterial Dipeptidyl Peptidase 4. PMID:28630069
Structure and Function of Viral Deubiquitinating Enzymes. PMID:28625850
Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae. PMID:28592490
Proteases of Dermatophagoides pteronyssinus. PMID:28587273
Identification of Proteases and Protease Inhibitors in Allergenic and Non-Allergenic Pollen. PMID:28587253
Differential stability of therapeutic peptides with different proteolytic cleavage sites in blood, plasma and serum. PMID:28575099
Metabolic network analysis reveals microbial community interactions in anammox granules. PMID:28561030
A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome. PMID:28512127
The expression of proline-specific enzymes in the human lung. PMID:28462210
Journey of cystatins from being mere thiol protease inhibitors to at heart of many pathological conditions. PMID:28445699
Programmatic access to bioinformatics tools from EMBL-EBI update: 2017. PMID:28431173
PRSS3 is a prognostic marker in invasive ductal carcinoma of the breast. PMID:28423522
Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria. PMID:28414448
Monitoring proteolytic processing events by quantitative mass spectrometry. PMID:28395554
The HCPro from the Potyviridae family: an enviable multitasking Helper Component that every virus would like to have. PMID:28371183
SheddomeDB: the ectodomain shedding database for membrane-bound shed markers. PMID:28361715
Phylogenomic evolutionary surveys of subtilase superfamily genes in fungi. PMID:28358043
Chromosome-Encoded Hemolysin, Phospholipase, and Collagenase in Plasmidless Isolates of Photobacterium damselae subsp. damselae Contribute to Virulence for Fish. PMID:28341681
Global Distribution Patterns and Pangenomic Diversity of the Candidate Phylum "Latescibacteria" (WS3). PMID:28314726
Evidence for Ancient Origins of Bowman-Birk Inhibitors from Selaginella moellendorffii. PMID:28298518
Riding the metalloproteinase roller coaster. PMID:28298437
Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins? PMID:28261087
Protein Dynamics in the Plant Extracellular Space. PMID:28248232
Metacaspases versus caspases in development and cell fate regulation. PMID:28234356
Development of a keratinase activity assay using recombinant chicken feather keratin substrates. PMID:28231319
A novel subtilase inhibitor in plants shows structural and functional similarities to protease propeptides. PMID:28223360
Matrix Metalloproteinases as Regulators of Periodontal Inflammation. PMID:28218665
Proteases of haematophagous arthropod vectors are involved in blood-feeding, yolk formation and immunity - a review. PMID:28193252
Functional diversity of secreted cestode Kunitz proteins: Inhibition of serine peptidases and blockade of cation channels. PMID:28192542
Myroilysin Is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Is Activated by a Cysteine Switch Mechanism. PMID:28188295
Draft genome sequence of Karnal bunt pathogen (Tilletia indica) of wheat provides insights into the pathogenic mechanisms of quarantined fungus. PMID:28152050
Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host. PMID:28107409
Recognition of protein-linked glycans as a determinant of peptidase activity. PMID:28096352
PACMANS: A bioinformatically informed algorithm to predict, design, and disrupt protease-on-protease hydrolysis. PMID:28078782
Plant genome and transcriptome annotations: from misconceptions to simple solutions. PMID:28062412
Major Cys protease activities are not essential for senescence in individually darkened Arabidopsis leaves. PMID:28061816
Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers. PMID:28060841
The 24th annual Nucleic Acids Research database issue: a look back and upcoming changes. PMID:28053160
A camel-derived MERS-CoV with a variant spike protein cleavage site and distinct fusion activation properties. PMID:27999426
Mirolysin, a LysargiNase from Tannerella forsythia, proteolytically inactivates the human cathelicidin, LL-37. PMID:27997347
Internet Databases of the Properties, Enzymatic Reactions, and Metabolism of Small Molecules-Search Options and Applications in Food Science. PMID:27929431
The Plastoglobule-Localized Metallopeptidase PGM48 Is a Positive Regulator of Senescence in Arabidopsis thaliana. PMID:27895226
Evidence that Processing of the Severe Fever with Thrombocytopenia Syndrome Virus Gn/Gc Polyprotein Is Critical for Viral Infectivity and Requires an Internal Gc Signal Peptide. PMID:27855227
Identification of a two-component Class IIb bacteriocin in Streptococcus pyogenes by recombinase-based in vivo expression technology. PMID:27808235
Phytocystatins: Defense Proteins against Phytophagous Insects and Acari. PMID:27775606
Matching the Diversity of Sulfated Biomolecules: Creation of a Classification Database for Sulfatases Reflecting Their Substrate Specificity. PMID:27749924
Insights from the Shell Proteome: Biomineralization to Adaptation. PMID:27744410
Convergent biosynthetic pathways to β-lactam antibiotics. PMID:27693891
Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis. PMID:27658724
Quantitative proteomics and terminomics to elucidate the role of ubiquitination and proteolysis in adaptive immunity. PMID:27644975
Proteases from Canavalia ensiformis: Active and Thermostable Enzymes with Potential of Application in Biotechnology. PMID:27630776
Time-scale dynamics of proteome and transcriptome of the white-rot fungus Phlebia radiata: growth on spruce wood and decay effect on lignocellulose. PMID:27602055
Sequencing and functional annotation of the whole genome of the filamentous fungus Aspergillus westerdijkiae. PMID:27527502
Membranome: a database for proteome-wide analysis of single-pass membrane proteins. PMID:27510400
MMpI: A WideRange of Available Compounds of Matrix Metalloproteinase Inhibitors. PMID:27509041
Plant senescence and proteolysis: two processes with one destiny. PMID:27505308
Draft Whole-Genome Sequence of the Type Strain Bacillus horikoshii DSM 8719. PMID:27417833
Regulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function. PMID:27022018
The European Bioinformatics Institute in 2016: Data growth and integration. PMID:26673705
MEROPS: the peptidase database PubMed citations: 221.

221 articles citing: MEROPS: the peptidase database

Genome-Wide Comprehensive Survey of the Subtilisin-Like Proteases Gene Family Associated With Rice Caryopsis Development. PMID:35795345
Contribution of proteases to the hallmarks of aging and to age-related neurodegeneration. PMID:35349763
E-Cadherin Orthologues as Substrates for the Serine Protease High Temperature Requirement A (HtrA). PMID:35327548
Evolutionary Origin of Insulin-Degrading Enzyme and Its Subcellular Localization and Secretion Mechanism: A Study in Microglial Cells. PMID:35053342
Two New M23 Peptidoglycan Hydrolases With Distinct Net Charge. PMID:34630350
Structural Characterization of EnpA D,L-Endopeptidase from Enterococcus faecalis Prophage Provides Insights into Substrate Specificity of M23 Peptidases. PMID:34281200
Characterization and Diversity Analysis of the Extracellular Proteases of Thermophilic Anoxybacillus caldiproteolyticus 1A02591 From Deep-Sea Hydrothermal Vent Sediment. PMID:33796092
Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme. PMID:33477364
The front line of defence: a meta-analysis of apoplastic proteases in plant immunity. PMID:33462613
The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans. PMID:33284103
How to use the MEROPS database and website to help understand peptidase specificity. PMID:32920969
Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms? PMID:32283690
Elevated CTSL2 expression is associated with an adverse prognosis in hepatocellular carcinoma. PMID:31949793
Sequencing and Functional Annotation of the Whole Genome of Shiraia bambusicola. PMID:31712259
Dealing With Stress: A Review of Plant SUMO Proteases. PMID:31620153
New Targets of Kunitz-Type Peptide from Sea Anemone Heteractis magnifica. PMID:31559593
Prospecting for microbial α-N-acetylgalactosaminidases yields a new class of GH31 O-glycanase. PMID:31530641
Properties of a Non-canonical Complex Formed Between a Tepary Bean (Phaseolus acutifolius) Protease Inhibitor and α-Chymotrypsin. PMID:31435809
A two-component protease in Methylorubrum extorquens with high activity toward the peptide precursor of the redox cofactor pyrroloquinoline quinone. PMID:31427437
The Oxymonad Genome Displays Canonical Eukaryotic Complexity in the Absence of a Mitochondrion. PMID:31387118
Structural and Functional Insights Into Lysostaphin-Substrate Interaction. PMID:30018958
Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors. PMID:29969929
The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database. PMID:29145643
Screening and identification of host proteins interacting with Theileria annulata cysteine proteinase (TaCP) by yeast-two-hybrid system. PMID:29084576
Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes. PMID:28476889
Overexpression of MpCYS4, A Phytocystatin Gene from Malus prunifolia (Willd.) Borkh., Enhances Stomatal Closure to Confer Drought Tolerance in Transgenic Arabidopsis and Apple. PMID:28174579
Sequencing and functional annotation of the whole genome of the filamentous fungus Aspergillus westerdijkiae. PMID:27527502
LytM Fusion with SH3b-Like Domain Expands Its Activity to Physiological Conditions. PMID:27351490
Microbial inhibitors of cysteine proteases. PMID:27048482
Whole genome annotation and comparative genomic analyses of bio-control fungus Purpureocillium lilacinum. PMID:26607873
Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors. PMID:26527717
Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi. PMID:26511477
High resolution structure of an M23 peptidase with a substrate analogue. PMID:26437833
The Paracaspase MALT1. PMID:26386283
The Amborella vacuolar processing enzyme family. PMID:26347753
Antibody proteolysis: a common picture emerging from plants. PMID:26186119
Polyglycine hydrolases: Fungal β-lactamase-like endoproteases that cleave polyglycine regions within plant class IV chitinases. PMID:25966977
MJD and OTU deubiquitinating enzymes in Schistosoma mansoni. PMID:25924794
Hidden relationships between metalloproteins unveiled by structural comparison of their metal sites. PMID:25820752
Why Ser and not Thr brokers catalysis in the trypsin fold. PMID:25664608
Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N. PMID:25644575
Novel in vitro inhibitory functions of potato tuber proteinaceous inhibitors. PMID:25260821
Using the SUBcellular database for Arabidopsis proteins to localize the Deg protease family. PMID:25161662
Characterization and expression analysis of chymotrypsin after bacterial challenge in the mud crab, Scylla paramamosain. PMID:25071403
Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans. PMID:25039253
Proteases in cardiometabolic diseases: Pathophysiology, molecular mechanisms and clinical applications. PMID:24815358
Extracellular proteases of Halobacillus blutaparonensis strain M9, a new moderately halophilic bacterium. PMID:24688526
Mechanistic insights into mode of actions of novel oligopeptidase B inhibitors for combating leishmaniasis. PMID:24567150
The genome of Spironucleus salmonicida highlights a fish pathogen adapted to fluctuating environments. PMID:24516394
A tale of two drug targets: the evolutionary history of BACE1 and BACE2. PMID:24381583
Conservation and developmental expression of ubiquitin isopeptidases in Schistosoma mansoni. PMID:24271000
Avian influenza virus h3 hemagglutinin may enable high fitness of novel human virus reassortants. PMID:24265752
Allosteric control of βII-tryptase by a redox active disulfide bond. PMID:24142694
Alternative mRNA splicing generates two distinct ADAM12 prodomain variants. PMID:24116070
Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression. PMID:24077280
Molecular cloning and homology modelling of a subtilisin-like serine protease from the marine fungus, Engyodontium album BTMFS10. PMID:24026932
Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress. PMID:23826334
Caspase substrates and inhibitors. PMID:23788633
Gingipain aminopeptidase activities in Porphyromonas gingivalis. PMID:23667904
The structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteases. PMID:23633592
Identification and prioritization of novel uncharacterized peptidases for biochemical characterization. PMID:23584835
Optimization and Immobilization of Purified Labeo rohita Visceral Protease by Entrapment Method. PMID:23533718
Primary analysis of the expressed sequence tags in a pentastomid nymph cDNA library. PMID:23437150
The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation. PMID:23405214
Oligopeptidases B from Trypanossoma cruzi and Trypanossoma brucei inhibit inflammatory pain in mice by targeting serotoninergic receptors. PMID:23377962
Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay. PMID:23359682
A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme. PMID:23257181
PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites. PMID:23209700
CyanoLyase: a database of phycobilin lyase sequences, motifs and functions. PMID:23175607
Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides. PMID:23056909
Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression. PMID:23028051
Activity, specificity, and probe design for the smallpox virus protease K7L. PMID:23012361
Cysteinyl cathepsins: multifunctional enzymes in cardiovascular disease. PMID:22977747
The maize cystatin CC9 interacts with apoplastic cysteine proteases. PMID:22960758
Homology modeling and functional annotation of bubaline pregnancy associated glycoprotein 2. PMID:22958467
Activation and proteolytic activity of the Treponema pallidum metalloprotease, pallilysin. PMID:22910436
Multimodal protein constructs for herbivore insect control. PMID:22822457
Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response. PMID:22806565
Toward stable genetic engineering of human O-glycosylation in plants. PMID:22791304
In vitro Ca(2+)-dependent maturation of milk-clotting recombinant Epr: minor extracellular protease: from Bacillus licheniformis. PMID:22736063
Biochemical characterization and structural modeling of human cathepsin E variant 2 in comparison to the wild-type protein. PMID:22718633
Functional protease profiling with reporter peptides in serum specimens of colorectal cancer patients: demonstration of its routine diagnostic applicability. PMID:22682081
Anti-staphylococcal activities of lysostaphin and LytM catalytic domain. PMID:22672475
Host proteolytic activity is necessary for infectious bursal disease virus capsid protein assembly. PMID:22619177
The YARHG domain: an extracellular domain in search of a function. PMID:22615736
Capturing single cell genomes of active polysaccharide degraders: an unexpected contribution of Verrucomicrobia. PMID:22536372
Structural and functional characterization of mature forms of metalloprotease E495 from Arctic sea-ice bacterium Pseudoalteromonas sp. SM495. PMID:22523598
The family of Deg/HtrA proteases in plants. PMID:22520048
Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. PMID:22493238
Eimeripain, a cathepsin B-like cysteine protease, expressed throughout sporulation of the apicomplexan parasite Eimeria tenella. PMID:22457711
A maize cystatin suppresses host immunity by inhibiting apoplastic cysteine proteases. PMID:22454455
Glu121-Lys319 salt bridge between catalytic and N-terminal domains is pivotal for the activity and stability of Escherichia coli aminopeptidase N. PMID:22411732
Mechanism and specificity of the human paracaspase MALT1. PMID:22309193
The Trypanosoma cruzi virulence factor oligopeptidase B (OPBTc) assembles into an active and stable dimer. PMID:22276197
The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis. PMID:22102243
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. PMID:22086950
Autoproteolytic activation of bacterial toxins. PMID:22069620
The multiple functions of plant serine protease inhibitors: defense against herbivores and beyond. PMID:22004998
Nodulin 41, a novel late nodulin of common bean with peptidase activity. PMID:21985276
Structural bioinformatics of Neisseria meningitidis LD-carboxypeptidase: implications for substrate binding and specificity. PMID:21983752
Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis. PMID:21919028
ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptides. PMID:21795676
The crystal structure of GXGD membrane protease FlaK. PMID:21765428
Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels. PMID:21761391
Genome-wide analysis of peptidase content and expression in a virulent and attenuated Babesia bovis strain pair. PMID:21741414
Independent subtilases expansions in fungi associated with animals. PMID:21727238
GPS-CCD: a novel computational program for the prediction of calpain cleavage sites. PMID:21533053
Production, purification, sequencing and activity spectra of mutacins D-123.1 and F-59.1. PMID:21477375
An HrpB-dependent but type III-independent extracellular aspartic protease is a virulence factor of Ralstonia solanacearum. PMID:21453432
Structural insights into the binding of MMP9 inhibitors. PMID:21383916
Molecular adaptation of a plant-bacterium outer membrane protease towards plague virulence factor Pla. PMID:21310089
A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells. PMID:21282205
A new principle of oligomerization of plant DEG7 protease based on interactions of degenerated protease domains. PMID:21247409
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. PMID:21245842
Serine protease inhibitors specifically defend Solanum nigrum against generalist herbivores but do not influence plant growth and development. PMID:21177479
Core genome components and lineage specific expansions in malaria parasites plasmodium. PMID:21143780
Identification and characterization of a bacterial glutamic peptidase. PMID:21122090
Affinity of Avr2 for tomato cysteine protease Rcr3 correlates with the Avr2-triggered Cf-2-mediated hypersensitive response. PMID:21118346
An atypical proprotein convertase in Giardia lamblia differentiation. PMID:21075147
Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae. PMID:21059706
The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion. PMID:20961853
Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor. PMID:20926390
Specialized roles for cysteine cathepsins in health and disease. PMID:20921628
Novel venom gene discovery in the platypus. PMID:20920228
Emerging principles in protease-based drug discovery. PMID:20811381
A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space. PMID:20799349
Design of thermostable beta-propeller phytases with activity over a broad range of pHs and their overproduction by Pichia pastoris. PMID:20693453
Genome-wide survey and evolutionary analysis of trypsin proteases in apicomplexan parasites. PMID:20691395
A critical tryptophan and Ca2+ in activation and catalysis of TPPI, the enzyme deficient in classic late-infantile neuronal ceroid lipofuscinosis. PMID:20689811
Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology. PMID:20675366
Serine protease activities in Leishmania (Leishmania) chagasi promastigotes. PMID:20668879
Functional analysis of the cucumisin propeptide as a potent inhibitor of its mature enzyme. PMID:20639575
The omptins of Yersinia pestis and Salmonella enterica cleave the reactive center loop of plasminogen activator inhibitor 1. PMID:20639337
Conservation and divergence of ADAM family proteins in the Xenopus genome. PMID:20630080
Inositol hexakisphosphate-induced autoprocessing of large bacterial protein toxins. PMID:20628577
Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs). PMID:20615447
Structure-function analysis of the short splicing variant carboxypeptidase encoded by Drosophila melanogaster silver. PMID:20600119
Allosteric regulation of protease activity by small molecules. PMID:20539873
Penduliflorain I: A cysteine protease isolated from Hohenbergia penduliflora (A.Rich.) Mez (Bromeliaceae). PMID:20521163
The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment. PMID:20507279
Thioesterases: a new perspective based on their primary and tertiary structures. PMID:20506386
Computational identification of uncharacterized cruzain binding sites. PMID:20485483
The TSG-6/HC2-mediated transfer is a dynamic process shuffling heavy chains between glycosaminoglycans. PMID:20463016
Metallo-aminopeptidase inhibitors. PMID:20457213
Studies on the catalytic mechanism of a glutamic peptidase. PMID:20442413
Alternative tasks of Drosophila tan in neurotransmitter recycling versus cuticle sclerotization disclosed by kinetic properties. PMID:20439462
Predicting conserved protein motifs with Sub-HMMs. PMID:20420695
The complete genome of Zunongwangia profunda SM-A87 reveals its adaptation to the deep-sea environment and ecological role in sedimentary organic nitrogen degradation. PMID:20398413
Structural features of plant subtilases. PMID:20173418
Sampling the N-terminal proteome of human blood. PMID:20173099
A large and accurate collection of peptidase cleavages in the MEROPS database. PMID:20157488
Practical application of bioinformatics by the multidisciplinary VIZIER consortium. PMID:20153379
An enriched structural kinase database to enable kinome-wide structure-based analyses and drug discovery. PMID:20135687
Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. PMID:20133942
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. PMID:20133781
Phytaspase, a relocalisable cell death promoting plant protease with caspase specificity. PMID:20111004
Crystal structure of the peptidase domain of Streptococcus ComA, a bifunctional ATP-binding cassette transporter involved in the quorum-sensing pathway. PMID:20100826
Activity-based mass spectrometric characterization of proteases and inhibitors in human saliva. PMID:20011683
Protease cleavage sites in HIV-1 gp120 recognized by antigen processing enzymes are conserved and located at receptor binding sites. PMID:19939935
The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin. PMID:19920152
Crystal structure of the protealysin precursor: insights into propeptide function. PMID:19915005
Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case. PMID:19913481
Network dynamics of eukaryotic LTR retroelements beyond phylogenetic trees. PMID:19883502
The global cysteine peptidase landscape in parasites. PMID:19854678
Versatile loops in mycocypins inhibit three protease families. PMID:19846555
A forward genetic strategy reveals destabilizing mutations in the Ebolavirus glycoprotein that alter its protease dependence during cell entry. PMID:19846533
Analysis of regulatory protease sequences identified through bioinformatic data mining of the Schistosoma mansoni genome. PMID:19845954
A family of diverse Kunitz inhibitors from Echinococcus granulosus potentially involved in host-parasite cross-talk. PMID:19759914
The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plague. PMID:19759820
Characterization of the entire cystatin gene family in barley and their target cathepsin L-like cysteine-proteases, partners in the hordein mobilization during seed germination. PMID:19759340
Pepsin homologues in bacteria. PMID:19758436
Yeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes. PMID:19750477
Arabidopsis LON2 is necessary for peroxisomal function and sustained matrix protein import. PMID:19748917
Novel features of the polysaccharide-digesting gliding bacterium Flavobacterium johnsoniae as revealed by genome sequence analysis. PMID:19717629
MUC1 is a substrate for gamma-secretase. PMID:19711367
Protein sectors: evolutionary units of three-dimensional structure. PMID:19703402
Issues about the physiological functions of prolyl oligopeptidase based on its discordant spatial association with substrates and inconsistencies among mRNA, protein levels, and enzymatic activity. PMID:19687473
Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites. PMID:19620709
Genomic and systems evolution in Vibrionaceae species. PMID:19594870
A membrane-bound matrix-metalloproteinase from Nicotiana tabacum cv. BY-2 is induced by bacterial pathogens. PMID:19563670
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. PMID:19561609
A sequence and structure based method to predict putative substrates, functions and regulatory networks of endo proteases. PMID:19492082
The single substitution I259T, conserved in the plasminogen activator Pla of pandemic Yersinia pestis branches, enhances fibrinolytic activity. PMID:19465664
RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs. PMID:19463860
Sequencing and characterization of asclepain f: the first cysteine peptidase cDNA cloned and expressed from Asclepias fruticosa latex. PMID:19455353
Identification, distribution and molecular evolution of the pacifastin gene family in Metazoa. PMID:19435517
Ixodes scapularis tick serine proteinase inhibitor (serpin) gene family; annotation and transcriptional analysis. PMID:19435496
The Rho GTPase inactivation domain in Vibrio cholerae MARTX toxin has a circularly permuted papain-like thiol protease fold. PMID:19434753
Serpin genes AtSRP2 and AtSRP3 are required for normal growth sensitivity to a DNA alkylating agent in Arabidopsis. PMID:19426562
RASMOT-3D PRO: a 3D motif search webserver. PMID:19417073
A feeding tube model for activation of a cell-specific transcription factor during sporulation in Bacillus subtilis. PMID:19390092
The protease-associated domain and C-terminal extension are required for zymogen processing, sorting within the secretory pathway, and activity of tomato subtilase 3 (SlSBT3). PMID:19332543
CPDadh: a new peptidase family homologous to the cysteine protease domain in bacterial MARTX toxins. PMID:19309740
Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini. PMID:19308250
Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3. PMID:19247445
Solution structure and backbone dynamics of streptopain: insight into diverse substrate specificity. PMID:19237546
Structure-Function, Stability, and Chemical Modification of the Cyanobacterial Cytochrome b6f Complex from Nostoc sp. PCC 7120. PMID:19189962
Cold adaptation of zinc metalloproteases in the thermolysin family from deep sea and arctic sea ice bacteria revealed by catalytic and structural properties and molecular dynamics: new insights into relationship between conformational flexibility and hydrogen bonding. PMID:19181663
Serine proteases. PMID:19180666
Bioinformatic flowchart and database to investigate the origins and diversity of clan AA peptidases. PMID:19173708
Metabolomics cuts to the chase to chase the cuts. PMID:19088710
Improved prediction of malaria degradomes by supervised learning with SVM and profile kernel. PMID:19057851
Genome-wide survey of prokaryotic serine proteases: analysis of distribution and domain architectures of five serine protease families in prokaryotes. PMID:19019219
Characterisation of novel protein families secreted by muscle stage larvae of Trichinella spiralis. PMID:18992250
Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. PMID:18957203
Structural elucidation of the Cys-His-Glu-Asn proteolytic relay in the secreted CHAP domain enzyme from the human pathogen Staphylococcus saprophyticus. PMID:18951393
The yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress. PMID:18946088
Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues. PMID:18813847
The Degradome database: mammalian proteases and diseases of proteolysis. PMID:18776217
Evolution of peptidase diversity. PMID:18768474
The ADAM metalloproteinases. PMID:18762209
Developing novel anthelmintics from plant cysteine proteinases. PMID:18761736
Quantitative and label-free technique for measuring protease activity and inhibition using a microfluidic cantilever array. PMID:18720973
Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor. PMID:18692070
The origin and evolution of plant cystatins and their target cysteine proteinases indicate a complex functional relationship. PMID:18616807
Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. PMID:18596030
Zinc regulation of aminopeptidase B involved in neuropeptide production. PMID:18571504
Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancer. PMID:18570381
MMP-12 catalytic domain recognizes triple helical peptide models of collagen V with exosites and high activity. PMID:18539597
Preventing unintended proteolysis in plant protein biofactories. PMID:18452504
Mutagenesis of the active-site cysteine in the ubiquitin-specific protease contained in large tegument protein pUL36 of pseudorabies virus impairs viral replication in vitro and neuroinvasion in vivo. PMID:18400848